Hermen Overkleeft
Hoogleraar Bio-organische synthese
- Naam
- Prof.dr. H.S. Overkleeft
- Telefoon
- +31 71 527 5037
- h.s.overkleeft@chem.leidenuniv.nl
- ORCID iD
- 0000-0001-6992-4760
Chemical Biology is de discipline waarin fundamentele biologische processen worden bestudeerd, door benaderingen die intrinsiek geworteld zijn in de chemie. Het onderzoek van Herman Overkleeft wordt gekenmerkt door ontwerp, synthese en toepassing van chemische probes in glycobiologie en immunologie.
Meer informatie over Hermen Overkleeft
Promovendi
Nieuws
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Kampioen in koolhydraatchemie: Hermen Overkleeft wint prestigieuze prijs -
De griep stopt als je het enzym blokkeert dat virusdeeltjes losknipt -
Nobelprijswinnares was in Leiden: ‘Een wetenschappelijke rockster in ons midden’ -
Nobelprijs voor scheikunde gaat naar ‘klikchemie’ -
Van ontdekking naar bedrijf: ‘In het lab realiseren we ons vaak niet dat we bezig zijn om ontiegelijk veel patiënten te helpen’ -
Klein molecuul gaat uitzaaien tumorcellen tegen -
‘Ook zonder patent moet het chemomiddel op de markt’ -
Van ontdekking in het lab naar een nieuw medicijn: de Venture Challenge maakt het mogelijk -
Scheikundig onderzoek voor betere chemotherapie finalist PNAS paper-prijs -
Een veelbelovend huwelijk tussen Siemens en Leidse spin-off Culgi -
ERC Synergy-beurs voor het ontcijferen van suiker-barcodes voor gezondheid en duurzaamheid -
Leidse ontdekking leidt tot nieuwe theorie voor enzymatische reacties -
Slimme scheikunde ontdoet antikankermedicijn van zware bijwerkingen
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Wetenschap vertalen in behandelingen voor zeldzame metabole ziekten -
Hermen Overkleeft en Sjaak Neefjes in de Volkskrant: waarom zou je als academicus nog op D66 stemmen? -
Europese samenwerking werpt licht op het ontdekken van industriële enzymen -
NWO TOP-subsidie voor twee Leidse chemici -
Michel Orrit en Hermen Overkleeft lid KNAW -
Op zoek naar betere medicijnen en behandelingen voor kanker -
Nieuwe cellulaire beeldtechniek voor kankeronderzoek -
Hermen Overkleeft wetenschappelijk directeur chemie-instituut LIC
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Marc Baggelaar promoveert cum laude op lichaamseigen marihuana -
Doorbraak Leidse wetenschappers in bestuderen ziekte van Pompe -
Waarom fundamentele wetenschap ertoe doet -
Medicijnontwikkeling, hoe kan het efficiënter? -
Hermen Overkleeft wint de 2015 Jeremy Knowles Award -
Chemische verbinding beïnvloedt afweersysteem -
Twee miljoen voor bio-chemisch onderzoek -
TA-premies voor onderzoek naar nieuwe geneesmiddelen voor kanker en allergieën -
Zwaartekracht subsidie toegekend voor Chemische Immunologie
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Ruim 50 miljoen voor vernieuwend onderzoek -
Leidse chemici brengen afvalverwerkingsfabriek van de cel in kaart -
Leidse wetenschappers pakken kanker aan de basis aan -
Hermen Overkleeft ontvangt Friedrich Wilhelm Bessel Research Award
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Chemische gereedschapkist in de strijd tegen kanker -
Opruimers gezocht voor cellen vol onverteerd afval -
Twee grote Europese subsidies voor Leidse bètahoogleraren Ewine van Dishoeck en Hermen Overkleeft -
Zenith subsidie voor Hermen Overkleeft -
Stofwisselingsenzym zichtbaar gemaakt in levend weefsel -
In memoriam Professor dr. Jan Cornelisse -
Dr. Tom Wennekes wint Farmacochemieprijs -
Herman Overkleeft wint gouden KNCV medaille
Vakken
Oud-promovendi
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Nancy Trenkler -
Vincent Lit
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Tyrza van Leeuwen
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Valentina Borlandelli
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Merijn Vriends
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Ward Doelman
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Michel van de Graaff
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Yurong Chen
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Mark de Geus
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Thomas Bakkum
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Linda Pieper
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Evert Peterse
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Alex van der Ham
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Mirjam Groenewold
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Berend Gagestein
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Casper de Boer
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Juan Zhou
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Sebastiaan Koenders
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Anouk van der Gracht
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Dennis Pascal Wander
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Tom van der Wel
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Kimberly Bonger
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Maria Walvoort
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Eva van Rooden
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Geoffroy Gential
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Ruud Wijdeven
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Sybrin Schröder
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Steven van Zutphen
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Patrick Wisse
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Daphne van Elsland
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Marc Baggelaar
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Thomas Beenakker
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Joanna Pawlak
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Hui Deng
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Bo-Tao Xin
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Bing Liu
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Nora Liu
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Jianbing Jiang
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Guillem Paniagua Soriano
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Gerjan de Bruin
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Freek Janssen
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Chung Wong
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Lianne Willems
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Kah-Jee Li
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Nan Li
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Harald Albers
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Amar Ghisaidoobe
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Wouter van der Linden
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Karl Gold
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Boudewijn Adriaan Duivenvoorden
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Annemiek Knijnenburg
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Paulus Geurink
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Matthijs van der Knaap
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Celia Berkers
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Vanita Kapoerchan
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Martin Witte
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Martijn Risseeuw
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Tom Wennekes
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Geerten Degenhart
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Martijn Verdoes
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Adriaan Tuin
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Leendert van den Bos
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Paul van Swieten
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Bas Lastdrager
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Farid El Oualid
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Remy Litjens
Meer informatie beschikbaar in op de Engelse profielpagina.
Hoogleraar Bio-organische synthese
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Bio-organic Synthesis
- Minnee H., Rack J.G.M., Marel G.A. van der, Overkleeft H.S., Codée J.D.C., Ahel I. & Filippov D.V. (2024), Solid-phase synthesis and biological evaluation of peptides ADP-Ribosylated at histidine, Angewandte Chemie (International Edition) 63(4): e202313317.
- Ruijgrok G., Wu D., Overkleeft H.S. & Codee J.D.C. (2024), Synthesis and application of bacterial exopolysaccharides, Current Opinion in Chemical Biology 78: 102418.
- Ofman T.P., Heming J.J.A., Nin-Hill A., Küllmer F., Moran E., Bennett M., Steneker R., Klein A.M., Ruijgrok G., Kok K., Armstrong Z.W.B., Aerts J.M.F.G., Marel G.A. van der, Rovira C., Davies G.J., Artola M.E., Codée J.D.C. & Overkleeft H.S. Rovira Carme Davies Gideon J. Artola Marta Codée Jeroen D. C. Overkleeft Herman S. (2024), Conformational and electronic variations in 1,2‐ and 1,5a‐Cyclophellitols and their impact on retaining α‐glucosidase inhibition, Chemistry: a European Journal 30(31): e202400723.
- Li Z., Pickles I.B., Sharma M., Melling B., Pallasdies L., Codee J.D.C., Williams S.J., Overkleeft H.S. & Davies G.J. (2024), Detection of sulfoquinovosidase activity in cell lysates using activity-based probes, Angewandte Chemie (International Edition) 63(26): e202401358.
- Artola Perez de Azanza M.E., Aerts J.M.F.G., Marel G.A. van der, Rovira C., Codee J.D.C., Davies G.J. & Overkleeft H.S. (2024), From mechanism-based retaining glycosidase inhibitors to activity-based glycosidase profiling, Journal of the American Chemical Society 146(36): 24729-24741.
- Koemans T.S., Bennett M., Guimaraes Da Lomba Ferraz M.J., Armstrong Z.W.B., Artola Perez de Azanza M.E., Aerts J.M.F.G., Codee J.D.C., Overkleeft H.S. & Davies G.J. (2024), Structure-guided design of C3-branched swainsonine as potent and selective human Golgi α-mannosidase (GMII) inhibitor, Chemical Communications : .
- Uddin M.J., Overkleeft H.S. & Lentz C.S. (2023), Activity-based protein profiling in methicillin-resistant staphylococcus aureus reveals the broad reactivity of a carmofur-derived probe, ChemBioChem 24(21): e202300473.
- Ofman T.P., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2023), Design and synthesis of exocyclic cyclitol aziridines as potential mechanism-based glycosidase inactivators, European Journal of Organic Chemistry 26(16): e202300186.
- Gracht D. van der, Rowland R.J., Roig-Zamboni V., Guimaraes Da Lomba Ferraz M.J., Louwerse G.A.M., Geurink P.P., Aerts J.M.F.G., Sulzenbacher G., Davies G.J., Overkleeft H.S. & Artola Perez de Azanza M.E. (2023), Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases, Chemical Science 14(34): 9136-9144.
- Minnee H., Chung H.W., Rack J.G.M., Marel G.A. van der, Overkleeft H.S., Codee J.D.C., Ahel I. & Filippov D.V. (2023), Four of a kind: a complete collection of ADP-ribosylated histidine isosteres using Cu(I)- and Ru(II)-catalyzed click chemistry, Journal of Organic Chemistry (JOC) 88(15): 10801-10809.
- Kuo C.L., Su Q., Nieuwendijk A.M.C.H. van den, Beenakker T.J.M., Offen W.A., Willems L.I., Boot R.G., Sarris A.J.C., Rosa Alcalde Marques A.R.A., Codée J.D.C., Marel G.A. van der, Florea B.I., Davies G.J., Overkleeft H.S. & Aerts J.M.F.G. (2023), The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe, Organic and Biomolecular Chemistry 21(38): 7813-7820.
- Wang Z., Poveda A., Zhang Q., Unione L., Overkleeft H.S., Marel G.A. van der, Jesus J.B. & Codee J.D.C. (2023), Total synthesis and structural studies of zwitterionic Bacteroides fragilis polysaccharide A1 fragments, Journal of the American Chemical Society 145(25): 14052-14063.
- Hengst J.M.A. van, Hellemons R.J.C., Remmerswaal W.A., Vrande K.N.A. van de, Hansen T., Vorm S. van der, Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2023), Mapping the effect of configuration and protecting group pattern on glycosyl acceptor reactivity, Chemical Science 14(6): 1532-1542.
- Gelder M.A., Zanden S.Y. van der, Vriends M.B.L., Wagensveld R.A., Marel G.A. van der, Codee J.D.C., Overkleeft H.S., Wander D.P.A. & Neefjes J.J.C. (2023), Re-exploring the anthracycline chemical space for better anti-cancer compounds, Journal of Medicinal Chemistry 66(16): 11390–11398.
- Reichart N.J., Steiger A.K., Fossen E.M. van, McClure R., Overkleeft H.S. & Wright A.T. (2023), Selection and enrichment of microbial species with an increased lignocellulolytic phenotype from a native soil microbiome by activity-based probing, ISME communications 3: 106.
- Wijngaarden S., Yang C., Vela-Rodríguez C., Lehtiö L., Overkleeft H.S., Paschal B.M. & Filippov D.V. (2023), Synthetic dual cysteine-ADP ribosylated peptides from the androgen receptor are recognized by the DTX3L/PARP9 complex, ACS Chemical Biology 18(11): 2377-2384.
- Males A., Kok K., Nin-Hill A., Koster N. de, Beukel S. van den, Beenakker T.J.M., Marel G.A. van der, Codée J.D.C., Aerts J.M.F.G., Overkleeft H.S., Rovira C., Davies G. & Artola Perez de Azanza M.E. (2023), Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump–hole strategy, Chemical Science 14(46): 13581-13586.
- McGregor N.G.S., Boer C. de, Foucart Q.P.O., Beenakker T., Offen W.A.., Codee J.D.C., Willems L.I., Overkleeft H.S. & Davies G.J. (2023), A multiplexing activity-based protein-profiling platform for dissection of a native bacterial xyloglucan-degrading system, ACS Central Science 9(12): 2306-2314.
- Chen Y., Nieuwendijk A.M.C.H. van den, Wu L., Moran E., Skoulikopoulou F., Riet V. van, Overkleeft H.S., Davies G.J. & Armstrong Z.W.B. (2023), Molecular basis for inhibition of heparanases and β-glucuronidases by siastatin B, Journal of the American Chemical Society 146(1): 125-133.
- Borlandelli V.B., Offen W., Moroz O., Nin-Hill A., Mcgregor N., Binkhorst L., Ishiwata A., Armstrong Z., Artola Perez de Azanza M.E., Rovira C., Davies G.J. & Overkleeft H.S. (2023), β-l-arabinofurano-cyclitol aziridines are covalent broad-spectrum inhibitors and activity-based probes for retaining β-l-arabinofuranosidases, ACS Chemical Biology 18(12): 2564-2573.
- Wang Z., Gimeno A., Lete M.G., Overkleeft H.S., Marel G.A., Chiodo F., Jiménez-Barbero J. & Codée J.D.C. (2023), Synthetic zwitterionic streptococcus pneumoniae Type 1 oligosaccharides carrying labile O-acetyl esters, Angewandte Chemie (International Edition) 62(1): e202211940.
- Borlandelli V., Armstrong Z., Nin-Hill A., Codée J., Raich L., Artola M., Rovira C., Davies G. & Overkleeft H.S. (2023), 4-O-substituted glucuronic cyclophellitols are selective mechanism-based heparanase inhibitors, ChemMedChem 18(4): e202200580.
- Lipsh-Sokolik R., Khersonsky O., Schröder S.P., Boer C. de, Hoch S.Y., Davies G.J., Overkleeft H.S. & Fleishman S.J. (2023), Combinatorial assembly and design of enzymes, Science 379(6628): 195-201.
- Zhou X., Besse A., Peter J., Steinhardt M.J., Vogt C., Nerreter S., Teufel E., Stanojkovska E., Xiao X., Hornburger H., Haertle L., Lopez M.M., Munawar U., Riedel A., Han S., Maurits E., Overkleeft H.S., Florea B.I., Einsele H., Kortüm K.M., Driessen C., Besse L. & Rasche L. (2023), High-dose carfilzomib achieves superior anti-tumor activity over lowdose and recaptures response in relapsed/refractory multiple myeloma resistant to low-dose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex, Haematologica 108(6): 1628-1639.
- Su Q., Schroder S.P., Lelieveld L.T., Guimaraes Da Lomba Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola Perez de Azanza M.E. & Kuo C.L. (2023), Corrigendum: Xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase, ChemBioChem 24(3): e202300728.
- McGregor N.G.S., Kuo C.L., Beenakker T.J.M., Wong C.S., Offen W.A., Armstrong Z.W.B., Florea B.I., Codee J.D.C., Overkleeft H.S., Aerts J.M.F.G. & Davies G.J. (2022), Synthesis of broad-specificity activity-based probes for exo-beta-mannosidases, Organic and Biomolecular Chemistry 20(4): 877-886.
- Zhang J., Walker M.E., Sanidad K.Z., Zhang H., Liang Y., Zhao E., Chacon-Vargas K., Yeliseyev V., Parsonnet J., Haggerty T.D., Wang G., Simpson J.B., Jariwala P.B., Beaty V.V., Yang J., Yang H., Panigrahy A., Minter L.M., Kim D., Gibbons J.G., Liu L., Li Z., Xiao H., Borlandelli V.B., Overkleeft H.S., Cloer E.W., Major M.B., Goldfarb D., Cai Z., Redinbo M.R. & Zhang G. (2022), Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract, Nature Communications 13(1): 136.
- Ham A. van der, Liu X., Calvani D., Melcrová A., Kozdra M., Buda F., Overkleeft H.S., Roos W.H., Filippov D.V. & Schneider G.F. (2022), Freestanding non-covalent thin films of the propeller-shaped polycyclic aromatic hydrocarbon decacyclene, Nature Communications 13(1): 1920.
- Gagestein B., Stevens A.F., Fazio D., Florea B.I., Wel T. van der, Bakker A.T., Fezza F., Dulk J. den, Overkleeft H.S., Maccarrone M. & Stelt M. van der (2022), Chemical proteomics reveals off-targets of the anandamide reuptake inhibitor WOBE437, ACS Chemical Biology 17(5): 1174-1183.
- Bertheussen K., Plassche M.A.T. van de, Bakkum T., Gagestein B., Ttofi I., Sarris A.J.C., Overkleeft H.S., Stelt M. van der & Kasteren S.I. van (2022), Live-cell imaging of sterculic acid - a naturally occurring 1,2-cyclopropene fatty acid - by bioorthogonal reaction with turn-on tetrazine-fluorophore conjugates, Angewandte Chemie (International Edition) 61(38): e202207640.
- Kok K., Kuo C.L., Katzy R.E., Lelieveld L.T., Wu L., Roig-Zamboni V., Marel G.A. van der, Codee J.D.C., Sulzenbacher G., Davies G.J., Overkleeft H.S., Aerts J.M.F.G. & Artola Perez de Azanza M.E. (2022), 1,6-epi-Cyclophellitol cyclosulfamidate is a bona fide lysosomal α-glucosidase stabilizer for the treatment of Pompe disease, Journal of the American Chemical Society 144(32): 14819-14827.
- Zhang Y., Wang L., Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2022), Assembly of a library of pel-oligosaccharides featuring α-glucosamine and α-galactosamine linkages, Frontiers in Chemistry 10: 842238.
- Boer C. de, Armstrong Z.W.B, Lit V.A.J., Barash U., Ruijgrok G., Boyango I., Weitzenberg M.M., Schröder S.P., Sarris A.J.C., Meeuwenoord N.J., Bule P., Kayal Y., Ilan N., Codee J.D.C., Vlodavsky I., Overkleeft H.S., Davies G.J. & Wu L. (2022), Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo, Proceedings of the National Academy of Sciences 119(31): e2203167119.
- Minnee H., Rack J.G.M., Marel G.A. van der, Overkleeft H.S., Codee J.D.C., Ahel I. & Filippov D.V. (2022), Mimetics of ADP-ribosylated histidine through copper(I)-catalyzed click chemistry, Organic Letters 24(21): 3776-3780.
- Remmerswaal W.A., Houthuijs K.J., Ven R. van de, Elferink H., Hansen T., Berden G., Overkleeft H.S., Marel G.A. van der, Rutjes F., Filippov D.V., Boltje T.J., Martens J., Oomens J. & Codee J.D.C. (2022), Stabilization of glucosyl dioxolenium Ions by "dual participation" of the 2,2-dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) protection group for 1,2-cis-glucosylation, Journal of Organic Chemistry (JOC) 87(14): 9139-9147.
- Klaus T., Ninck S., Albersmeier A., Busche T., Wibberg D., Jiang J., Elcheninov A.G., Zayulina K.S., Kaschani F., Bräsen C., Overkleeft H.S., Kalinowski. J., Kublanov I.V., Kaiser M. & Siebers B. (2022), Activity-based protein profiling for the identification of novel carbohydrate-active enzymes involved in xylan degradation in the hyperthermophilic euryarchaeon thermococcus sp. Strain 2319x1E, Frontiers in Microbiology 12: 734039.
- McGregor N.G.S., Boer C. de, Santos M., Haon M., Navarro D., Schröder S.P., Berrin J.G., Overkleeft H.S. & Davies G.J. (2022), Activity-based protein profiling reveals dynamic substrate-specific cellulase secretion by saprotrophic basidiomycetes, Biotechnology for Biofuels and Bioproducts 15: 6.
- McGregor N.G.S., Overkleeft H.S. & Davies G.J. (2022), Chapter five - detecting and identifying glycoside hydrolases using cyclophellitol-derived activity-based probes. In: Carlson E.E. (red.), Chemical microbiology part A. Methods in Enzymology nr. 664: Elsevier. 103-134.
- Besse A., Kraus M., Mendez-Lopez M., Maurits E., Overkleeft H.S., Driessen C. & Besse L. (2022), Immunoproteasome activity in chronic lymphocytic leukemia as a target of the immunoproteasome-selective inhibitors, Cells 11(5): 838.
- Katzy R.E., Guimaraes Da Lomba Ferraz M.J., Hazeu M.D., Overkleeft H.S. & Aerts J.M.F.G. (2022), In situ glucosylceramide synthesis and its pharmacological inhibition analysed in cells by 13C5-sphingosine precursor feeding and mass spectrometry, FEBS Letters 596(18): 2400-2408.
- Peterse E., Meeuwenoord N.J., Elst H. van den, Marel G.A. van der, Overkleeft H.S. & Filippov D.V. (2022), Solid-phase synthesis of macrocyclic peptides via side-chain anchoring of the ornithine delta-amine, European Journal of Organic Chemistry 2022(11): e202101341.
- Simpson J.B., Sekala J.J., Graboski A.L., Borlandelli V.B., Bivins M.M., Barker N.K., Sorgen A.A., Mordant A.L., Johnson R.L., Bhatt A.P., Fodor A.A., Herring L.E., Overkleeft H.S., Lee J.R. & Redinbo M.R. (2022), Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate, Gut Microbes 14(1): e2107289 .
- Voorneveld J., Kloet M.S., Wijngaarden S., Kim R.Q., Moutsiopoulou A., Verdegaal M., Misra M., Dikic I., Marel G.A. van der, Overkleeft H.S., Filippov D.V. & Noort G.J.V. van (2022), Arginine ADP-ribosylation: chemical synthesis of post-translationally modified ubiquitin proteins, Journal of the American Chemical Society 144(45): 20582-20589.
- Gagestein B., von Hegedus J.H., Kwekkeboom J.C., Heijink M., Blomberg N., Wel T. van der, Florea B.I., Elst H. van der, Wals K., Overkleeft H.S., Giera M., Toes R.E.M., Ioan-Facsinay A. & Stelt M. van der (2022), Comparative photoaffinity profiling of omega-3 signaling lipid probes reveals prostaglandin reductase 1 as a metabolic hub in human macrophages, Journal of the American Chemical Society 144(41): 18938–18947.
- Schmerling C., Sewald L., Heilmann G., Witfeld F., Begerow D., Jensen K., Brasen C., Kaschani F., Overkleeft H.S., Siebers B. & Kaiser M. (2022), Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling, Communications Biology 5(1): 1254.
- Torres-Garcia D., Plassche M.A.T. van de, Boven E. van, Leeuwen T. van, Groenewold M.G.J., Sarris A.J.C., Klein L., Overkleeft H.S. & Kasteren S.I. van (2022), Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activities in situ, RSC Chemical Biology 3(11): 1325-1330.
- Schmerling C., Sewald L., Heilmann G., Witfeld F., Begerow D., Jensen K., Bräsen C., Kaschani F., Overkleeft H.S., Siebers B. & Kaiser M. (2022), Author Correction: identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling, Communications Biology 5: 1319 (1319).
- Ende T.C. van den, Heuts J.M.M., Gential G.P.P., Visser M., Graaff M.J. van de, Ho N.I., Jiskoot W., Valentijn A.R.P.M., Meeuwenoord N.J., Overkleeft H.S., Codée J.D.C., Burg S.H. van der, Verdegaal E.M.E., Marel G.A. van der, Ossendorp F. & Filippov D.V. (2021), Simplified monopalmitoyl toll-like receptor 2 ligand mini-UPam for self-adjuvanting neoantigen-based synthetic cancer vaccines, ChemBioChem 22(7): 1215-1222.
- Jongsma M.L.M., Waard A.A. de, Raaben M., Zhang T., Cabukusta B., Platzer R., Blomen V.A., Xagara A., Verkerk T., Bliss S., Kong X., Gerke C., Janssen L., Stickel E., Holst S., Plomp R., Mulder A., Ferrone S., Claas F.H.J., Heemskerk M.H.M., Griffioen M., Halenius A., Overkleeft H.S., Huppa J.B., Wuhrer M., Brummelkamp T.R., Neefjes J. & Spaapen R.M. (2021), The SPPL3-defined glycosphingolipid repertoire orchestrates HLA class I-mediated immune responses, Immunity 54(1): 132-150.
- Chen Y., Armstrong Z., Artola M., Florea B.I., Kuo C.L., Boer C. de, Rasmussen M.S., Abou Hachem M., Marel G.A. van der, Codee J.D.C., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2021), Activity-based protein profiling of retaining alpha-amylases in complex biological samples, Journal of the American Chemical Society 143(5): 2423-2432.
- McGregor N.G.S., Coines J., Borlandelli V.B., Amaki S., Artola M., Nin-Hill A., Linzel D., Yamada C., Arakawa T., Ishiwata A., Ito Y., Marel G.A. van der, Codee J.D.C., Fushinobu S., Overkleeft H.S., Rovira C. & Davies G.J. (2021), Cysteine nucleophiles in glycosidase catalysis: application of a covalent β‐l‐arabinofuranosidase inhibitor, Angewandte Chemie (International Edition) 60(11): 5754-5758.
- Marneth K., Elst H. van den, Cramer-Blok A.J., Codee J.D.C., Overkleeft H.S., Aerts J.M.F.G., Ubbink M. & Ben Bdira F. (2021), Tuning the transglycosylation reaction of a GH11 xylanase by a delicate enhancement of its thumb flexibility, ChemBioChem 22(10): 1743-1749.
- Rayo J., Gregor R., Jacob N.T., Dandela R., Dubinsky L., Yashkin A., Aranovich A., Thangaraj M., Ernst O., Barash E., Malitsky S., Florea B.I., Krom B.P., Wiemer E.A.C., Kickhoefer V.A., Rome L.H., Mathison J.C., Kaufmann G.F., Overkleeft H.S., Cravatt B.F., Zor T., Janda K.D., Ulevitch R.J., Kravchenko V.V. & Meijler M.M. (2021), Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones, Proceedings of the National Academy of Sciences 118(12 ): e2012529118.
- Kok K., Zwiers K.C., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Artola M. (2021), Fabry disease: molecular basis, pathophysiology, diagnostics and potential therapeutic directions, Biomolecules 11(2): 271.
- Leeuwen T. van, Araman C., Pournara L.P., Kampstra A.S.B., Bakkum T., Marqvorsen M.H.S., Nascimento C.R., Groenewold G.J.M., Wulp W. van der, Camps M.G.M., Janssen G.M.C., Veelen P.A. van, Westen G.J.P. van Janssen A.P.A., Florea B.I., Overkleeft H.S., Ossendorp F.A., Toes R.E.M. & Kasteren S.I. van (2021), Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens, RSC Chemical Biology 2(3): 855-862.
- Wander D.P.A., Zanden S.Y. van der, Vriends M.B.L. Veen B.C. van, Vlaming J.G.C., Bruyning T., Hansen T., Marel G.A. van der, Overkleeft H.S., Neefjes J.J.C. & Codée J.D.C. (2021), Synthetic (N,N-dimethyl)doxorubicin glycosyl diastereomers to dissect modes of action of anthracycline anticancer drugs, Journal of Organic Chemistry (JOC) 86(8): 5757-5770.
- Ali S., Hendriks A., Dalen R. van, Bruyning T., Meeuwenoord N., Overkleeft H.S., Filippov D.V., Marel G.A. van der Sorge N.M. van & Codee J.D.C. (2021), (Automated) synthesis of well-defined staphylococcus aureus wall teichoic acid fragments, Chemistry: a European Journal 27(40): 10461-10469.
- Berni F., Wang L., Kalfopoulou E., Nguyen D.L., Es D. van der, Hübner J., Overkleeft H.S., Hokke C.H., Marel G.A. van der, Diepen A. van & Codée J.D.C. (2021), Generation of glucosylated sn-1-glycerolphosphate teichoic acids: glycerol stereochemistry affects synthesis and antibody interaction, RSC Chemical Biology 2(1): 187-191.
- Voorneveld J., Rack J.G.M., Gijlswijk L.M. van, Meeuwenoord N.J., Liu Q., Overkleeft H.S., Marel G.A. van der, Ahel I. & Filippov D.V. (2021), Molecular tools for the study of ADP-Ribosylation: a unified and versatile method to synthesise native mono-ADP-ribosylated peptides, Chemistry: a European Journal 27(41): 10621-10627.
- Besse L., Besse A., Stolze S.C., Sobh A., Zaal E.A., Ham A.J. van der, Ruiz M., Phuyal S., Büchler L., Sathianathan M., Florea B.I., Borén J., Ståhlman M., Huber J., Bolomsky A., Ludwig H., Hannich J.T., Loguinov A., Everts B., Berkers C.R., Pilon M., Farhan H., Vulpe C.D., Overkleeft H.S. & Driessen C. (2021), Treatment with HIV-protease inhibitor nelfinavir identifies membrane lipid composition and fluidity as a therapeutic target in advanced multiple myeloma, Cancer Research 81(17): 4581-4593.
- Schroder S.P., Offen W.A., Males A., Jin Y., Boer C. de, Enotarpi J., Marino L., Marel G.A. van der, Florea B.I., Codee J.D.C., Overkleeft H.S. & Davies G.J. (2021), Development of Non-Hydrolysable Oligosaccharide Activity-Based Inactivators for Endoglycanases: A Case Study on alpha-1,6 Mannanases, Chemistry: a European Journal 27(37): 9519-9523.
- Ham A. van der, Overkleeft H.S., Filippov D.V. & Schneider G.F. (2021), A three-step synthesis of 4H-cyclopenta[def]phenanthrene from pyrene, European Journal of Organic Chemistry 2021(13): 2013-2017.
- Liu Q., Knobloch G., Voorneveld J., Meeuwenoord N.J., Overkleeft H.S., Marel G.A. van der, Ladurner A.G. & Filippov D.V. (2021), Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1, Chemical Science 12(37): 12468-12475.
- Boer D.E., Mirzaian M., Ferraz M.J., Zwiers K.C., Baks M.V., Hazeu M.D., Ottenhoff R., Marques A.R.A., Meijer R., Roos J.C.P., Cox T.M., Boot R.G., Pannu N., Overkleeft H.S., Artola M. & Aerts J.M.F.G. (2021), Human glucocerebrosidase mediates formation of xylosyl-cholesterol by beta-xylosidase and transxylosidase reactions, Journal of Lipid Research 62: 100018.
- Marcoux G., Laroche A., Hasse S., Bellio M., Mbarik M., Tamagne M., Allaeys I., Zufferey A., Lévesque T., Rebetz J., Karakeussian-Rimbaud A., Turgeon J., Bourgoin S.G., Hamzeh-Cognasse H., Cognasse F., Kapur R., Semple J.W., Hebert M.J., Pirenne F., Overkleeft H.S., Florea B.I., Dieude M., Vingert B. & Boilard E. (2021), Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules, Blood 138(25): 2607-2620.
- Mazilescu L.I., Urbanellis P., Kaths M.J., Ganesh S., Goto T., Noguchi Y., John R., Konvalinka A., Mucsi I., Ghanekar A., Bagli D.J., Turgeon J., Karakeusian Rimbaud A., Hébert M.J., Dieudé M., Alleys I., Dore E., Boilard E., Overkleeft H.S., Willems L.I., Robinson L.A. & Selzner M. (2021), Prolonged normothermic ex vivo kidney perfusion is superior to cold nonoxygenated and oxygenated machine perfusion for the preservation of DCD porcine kidney grafts, Transplantation Direct 7(10): e751.
- Su Q., Schröder S.P., Lelieveld L.T., Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola M. & Kuo C.L. (2021), Xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase, ChemBioChem 22(21): 3090-3098.
- Berni F., Kalfopoulou E., Gimeno Cardells A.M., Carboni F., Es D. van der, Romero-Saavedra F., Laverde D., Miklic K., Malic S., Rovis T.L., Jonjic S., Ali S., Overkleeft H.S., Hokke C.H., Diepen A. van, Adamo R., Jiménez-Barbero J., Marel G.A. van der, Huebner J. & Codée J.D.C. (2021), Epitope recognition of a monoclonal antibody raised against a synthetic glycerol phosphate based teichoic acid, ACS Chemical Biology 16(8): 1344-1349.
- Rowland R.J., Chen Y., Breen I., Wu L., Offen W.A., Beenakker T.J.M., Su Q., Nieuwendijk A.M.C.H. van den, Aerts J.M.F.G., Artola Perez de Azanza M.E., Overkleeft H.S. & Davies G.J. (2021), Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents, Chemistry: a European Journal 27: 1-13.
- Ofman T.P., Küllmer F., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2021), An orthogonally protected cyclitol for the construction of nigerose- and dextran-mimetic cyclophellitols, Organic Letters 23(24): 9516-9519.
- Boer C. de, McGregor N.G.S., Peterse E., Schröder S.P., Florea B.I., Jiang J., Reijngoud J., Ram A.F.J., Wezel G.P. van, Marel G.A. van der, Codee J.D.C., Overkleeft H.S. & Davies G.J. (2021), Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases, RSC Chemical Biology 2(6): 1701.
- Mendez M., Andrej B., Florea B.I., Christian Z., Overkleeft H.S., Lenka B. & Driessen C. (2021), Carfilzomib-induced acute cardiotoxicity is mediated through angiotensin and caused by cardiomyocyte energy depletion, Clinical Lymphoma, Myeloma and Leukemia 21(2): S122.
- Besse L., Besse A., Kraus M., Maurits E., Overkleeft H.S., Bornhauser B., Bourquin J.P. & Driessen C. (2021), High immunoproteasome activity and sXBP1 in pediatric precursor B-ALL predicts sensitivity towards proteasome inhibitors, Cells 10(11): 2853.
- Scherer M., Santana A.G., Robinson K., Zhou S., Overkleeft H.S., Clarke L. & Withers S.G. (2021), Lipid-mimicking phosphorus-based glycosidase inactivators as pharmacological chaperones for the treatment of Gaucher's disease, Chemical Science 12(41): 13909-13913.
- Overkleeft H.S., Xin B.T., Espinal C.G.A., Bruin G. de, Filippov D.V., Marel G.A. van der & Florea B.I. (2020), Two-step bioorthogonal activity-based protein profiling of individual human proteasome catalytic sites, ChemBioChem 21(1-2): 248-255.
- Hogervorst T.P., Li R.J.E., Marino L., Bruijns S.C.M., Meeuwenoord N.J., Filippov D.V., Overkleeft H.S., Marel G.A. van der, Vliet S.J. van, Kooyk Y. van & Codée J.D.C. (2020), C-Mannosyl Lysine for Solid Phase Assembly of Mannosylated Peptide Conjugate Cancer Vaccines, ACS Chemical Biology 15(3): 728-739.
- McGregor N.G.S., Artola M., Nin-Hill A., Linzel D., Haon M., Reijngoud J., Ram A., Rosso M.N., Marel G.A. van der, Codée J.D.C., Wezel G.P. van, Berrin J.G., Rovira C., Overkleeft H.S. & Davies G.J. (2020), Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases, Journal of the American Chemical Society 142(10): 4648-4662.
- Boer D.E.C., Smeden J. van, Al-Khakany H., Melnik E., Dijk R. van, Absalah S., Vreeken R.J., Haenen C.C.P., Lavrijsen A.P.M., Overkleeft H.S., Aerts J.M.F.G. & Bouwstra J.A. (2020), Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865(6): 158673.
- Geus M.A.R. de, Maurits E., Sarris A.J.C., Hansen T., Kloet M.S., Kamphorst K., Hoeve W. ten, Robillard M.S., Pannwitz A., Bonnet S.A., Codée J.D.C., Filippov D.V., Overkleeft H.S. & Kasteren S.I. van (2020), Fluorogenic Bifunctional Trans-cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics, Chemistry: a European Journal 26(44): 9900-9904.
- Wang L., Zhang Y., Overkleeft H.S., Marel G.A. van der & Codée J.D.C. (2020), Reagent controlled glycosylations for the assembly of well-defined Pel oligosaccharides, Journal of Organic Chemistry (JOC) 85(24): 15872-15884.
- Anoniem (2020), Reagent controlled stereoselective synthesis of teichoic acid α-(1,2)-glucans [Glycovax] (vertaling Wang L., Berni F., Enotarpi J., Overkleeft H.S., Marel G.A. van der & Codée J.D.C.), Organic and Biomolecular Chemistry 18(11): 2038-2050.
- Codée J.D.C., Zhang Y., Gómez-Redondo M., Jiménez-Osés G., Arda A., Overkleeft H.S., Marel G.A. van der & Jiménez-Barbero J. (2020), Synthesis and structural analysis of Aspergillus fumigatus galactosaminogalactans featuring α-galactose, α-galactosamine and α-N-acetyl galactosamine linkages, Angewandte Chemie (International Edition) 59(31): 12746-12750.
- Mechelen J. van, Voorneveld J., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codée J.D.C. (2020), Synthesis of orthogonally protected and functionalized bacillosamines, Organic and Biomolecular Chemistry 18(15): 2834-2837.
- Maurits E., Graaff M.J. van de, Maiorana S., Wander D.P.A., Dekker P.M., Zanden S.Y. van der, Florea B.I., Neefjes J.J.C., Overkleeft H.S. & Kasteren S.I. van (2020), Immunoproteasome inhibitor-doxorubicin conjugates target multiple myeloma cells and release doxorubicin upon low-dose photon irradiation, Journal of the American Chemical Society 142(16): 7250-7253.
- Kytidou K., Artola M., Overkleeft H.S. & Aerts J.M.F.G. (2020), Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics, Frontiers in Plant Science 11: 357.
- Smeden J. van, Al-Khakany H., Wang Y., Visscher D., Stephens N., Absalah S., Overkleeft H.S., Aerts J.M.F.G., Hovnanian A. & Bouwstra J.A. (2020), Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities, Journal of Lipid Research 61(6): 859-869.
- Hansen T. Elferink H. Hengst J.M.A. van Houthuijs K.J. Remmerswaal W.A. Kromm A. Berden G. Vorm S. van der Rijs A.M. Overkleeft H.S. Filippov D.V. Rutjes F.P.J.T. Marel G.A. van der Martens J. Oomens J. Codée J.D.C. Boltje T.J. (2020), Characterization of glycosyl dioxolenium ions and their role in glycosylation reactions, Nature Communications 11(1): 2664.
- Ubbink M., Ben Bdira F, Waudby C.A., Volkov A.N., Schröder S.P., Ab E., Codée J.D.C., Overkleeft H.S., Aerts J.M.F.G. & Ingen H. van (2020), Dynamics of ligand binding to a rigid glycosidase, Angewandte Chemie (International Edition) 59(46): 20508-20514.
- Armstrong Z., Kuo C.L., Lahav D., Liu B., Johnson R., Beenakker T.J.M., Boer C. de, Wong C.S., Rijssel E.R. van, Debets M.F., Florea B.I., Hissink C., Boot R.G., Geurink P.P., Ovaa H., Stelt M. van der, Marel G.A. van der, Codée J.D.C., Aerts J.M.F.G., Wu L., Overkleeft H.S. & Davies G.J. (2020), Manno-epi-cyclophellitols enable activity-based protein profiling of human α-mannosidases and discovery of new golgi mannosidase II inhibitors, Journal of the American Chemical Society 142(30): 13021-13029.
- Wel T. van der Hilhorst R Dulk H. den Hooven T. van den Prins N.M. Wijnakker J.A.P.M. Florea B.I. Lenselink E.B. Westen G.J.P. van Ruijtenbeek R. Overkleeft H.S. Kaptein A. Barf T. Stelt M. van der (2020), Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis, Nature Communications 11(1): 3216.
- Selkrig J., Li N., Hausmann A., Mangan M.S.J., Zietek M., Mateus A., Bobonis J., Sueki A., Imamura H., El Debs B., Sigismondo G., Florea B.I., Overkleeft H.S., Kopitar-Jerala N., Turk B., Beltrao P., Savitski M.M., Latz E., Hardt W.D., Krijgsveld J. & Typas A. (2020), Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection, Nature Microbiology 5: 1119-1133.
- Maurits E. Degeling C.G. Kisselev A.F. Florea B.I. Overkleeft H.S. (2020), Structure-based design of fluorogenic substrates selective for human proteasome subunits, ChemBioChem 21(22): 3220-3224.
- Qiao X., Zanden S.Y. van der, Wander D.P.A., Borràs D.M., Song J.Y., Li X., Duikeren S. van, Gils N. van, Rutten A., Herwaarden T. van, Tellingen O. van, Giacomelli E., Bellin M., Orlova V., Tertoolen L.G.J., Gerhardt S., Akkermans J.J., Bakker J.M., Zuur C.L., Pang B., Smits A.M., Mummery C.L., Smit L., Arens R., Li J., Overkleeft H.S. & Neefjes J.J.C. (2020), Uncoupling DNA damage from chromatin damage to detoxify doxorubicin, Proceedings of the National Academy of Sciences 117(26): 15182-15192.
- Voorneveld J., Florea B.I., Bakkum T., Mendowicz R.J., Veer M.S. van der, Gagestein B., Kasteren S.I. van, Stelt M. van der, Overkleeft H.S. & Filippov D.V. (2020), Olaparib-Based Photoaffinity Probes for PARP-1 Detection in Living Cells, ChemBioChem 21: 1-5.
- Koenders S.T.A., Rooden E.J. van, Elst H. van den, Florea B.I., Overkleeft H.S. & Stelt M. van der (2020), STA-55, an Easily Accessible, Broad-Spectrum, Activity-Based Aldehyde Dehydrogenase Probe, ChemBioChem 21: 1911-1917.
- Enotarpi J.Tontini M. Balocchi C. Es D. van der Auberger L. Balducci E. Carboni F. Proietti D. Casini D. Filippov D.V. Overkleeft H.S. Marel G.A. van der Colombo C. Romano M.R. Berti F. Costantino P. Codeé J.D.C. Lay L. Adamo R. (2020), A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A, Nature Communications 11: 4434.
- Reintjens N.R.M., Tondini E., Vis C., McGlinn T., Meeuwenoord N.J., Hogervorst T.P., Overkleeft H.S., Filippov D.V., Marel G.A. van der, Ossendorp F.A. & Codée J.D.C. (2020), Multivalent, stabilized mannose-6-phosphates for the targeted delivery of toll-like receptor ligands and peptide antigens, ChemBioChem 22(2): 434-440.
- Hansen T., Ofman T.P., Vlaming J.G.C., Gagarinov I.A., Beek J. van, Goté T.A., Tichem J.M., Ruijgrok G., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codée J.D.C. (2020), Reactivity-stereoselectivity mapping for the assembly of Mycobacterium marinum lipooligosaccharides, Angewandte Chemie (International Edition) 60(2): 937-945.
- Reintjens N.R.M., Koemans T.S., Zilverschoon N., Castelli R., Cordfunke R.A., Drijfhout J.W., Meeuwenoord N.J., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codée J.D.C. (2020), Synthesis of C-Glycosyl Amino Acid Building Blocks Suitable for the Solid-Phase Synthesis of Multivalent Glycopeptide Mimics, European Journal of Organic Chemistry 2020(32): 5126-5139.
- Luijkx Y. Bleumink N. Jiang J. Overkleeft H.S. Wösten M. Strijbis K. Wennekes T. (2020), Bacteroides fragilis fucosidases facilitate growth and invasion of Campylobacter jejuni in the presence of mucins, Cellular Microbiology 22(12): e13252.
- Neefjes J.J.C., Overkleeft H.S., Ploegh H.L. & Schulman B. (2020), Obituary Huib Ovaa (1973-2020), Cell chemical biology 27(6): 645-646.
- Bakhonsky V.V., Pashenko A.A., Becker J., Hausmann H., Groot H.J.M. de, Overkleeft H.S., Fokin A.A. & Schreiner P.R. (2020), Synthesis and antiproliferative activity of hindered, chiral 1,2-diaminodiamantane platinum(II) complexes, Dalton Transactions 49(40): 14009-14016.
- Wander D.P.A., Zanden S.Y. van der, Marel G.A. van der, Overkleeft H.S., Neefjes J.J.C. & Codee J.D.C. (2020), Doxorubicin and aclarubicin: shuffling anthracycline glycans for improved anticancer agents, Journal of Medicinal Chemistry 63(21): 12814-12829.
- Boer D.E.C., Mirzaian M., Ferraz M.J., Zwiers K.C., Baks M.V., Hazeu M.D., Ottenhoff R., Marques A.R.A., Meijer R., Roos J.P.C., Cox T.M., Boot R.G., Pannu N., Overkleeft H.S., Artola M. & Aerts J.M.F.G. (2020), Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions, Journal of Lipid Research 61(12): jlr.RA120001043.
- Enotarpi J., Tontini M., Balocchi C., Es D. van der, Auberger L.C., Balducci E., Carboni F., Proietti D., Casini D., Filippov D.V., Overkleeft H.S., Marel G.A. van der, Colombo C., Romano M.R., Berti F., Costantino P., Codeé J.D.C., Lay L. & Adamo R. (2020), Publisher correction: a stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A, Nature Communications 11(1): 6155.
- Reintjens N.R.M., Tondini E., Jong A.R. de, Meeuwenoord N.J., Chiodo F., Peterse E., Overkleeft H.S., Filippov D.V., Marel G.A. van der, Ossendorp F.A. & Codée J.D.C. (2020), Self-adjuvanting cancer vaccines from conjugation-ready lipid A analogues and synthetic long peptides, Journal of Medicinal Chemistry 63(20): 11691-11706.
- McGregor N.G.S., Turkenburg J.P., Krogh K.B.R.M., Nielsen J.E., Artola M., Stubbs K.A., Overkleeft H.S. & Davies G.J. (2020), Structure of a GH51 α-L-arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi, Acta Crystallographica Section D Structural Biology 76(11): 1124-1133.
- Boer C. de, McGregor N.G.S., Peterse E., Schröder S.P., Florea B.I., Jiang J., Reijngoud J., Ram A.F.J., Wezel G.P. van, Marel G.A. van der, Codée J.D.C., Overkleeft H.S. & Davies G.J. (2020), Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases, RSC Chemical Biology 1(3): 148-155.
- Artola M., Kuo C.L., Lelieveld L.T., Rowland R.J., Marel G.A. van der, Codée J.D.C., Boot R.G., Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2019), Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish, Journal of the American Chemical Society 141(10): 4214-4218.
- Madern J.M., Hansen T., Rijssel E.R. van, Kistemaker H.A.V., Vorm S. van der, Overkleeft H.S., Marel G.A. van der, Filippov D.V. & Codee J.D.C. (2019), Synthesis, Reactivity, and Stereoselectivity of 4-Thiofuranosides, Journal of Organic Chemistry (JOC) 84(3): 1218-1227.
- Zom G.G., Willems M.M.J.H.P., Meeuwenoord N., Reintjens N.R.M., Tondini E., Khan S., Overkleeft H.S., Marel G.A. van der, Codée J.D.C., Ossendorp F. & Filippov D.V. (2019), Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells, Bioconjugate Chemistry 30(4): 1150-1161.
- Vorm S. van der, Hansen T., Rijssel E.R. van, Dekkers R., Madern J.M., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codée J.D.C. (2019), Furanosyl oxocarbenium ion Conformational Energy Landscape maps as a tool to study the glycosylation stereoselectivity of 2-azidofuranoses, 2-fluorofuranoses and methyl furanosyl uronates, Chemistry: a European Journal 25(29): 7149-7157.
- Meel E. van, Bos E., Lienden M.J.C. van der, Overkleeft H.S., Kasteren S.I. van, Koster A.J. & Aerts J.M.F.G. (2019), Localization of Active Endogenous and Exogenous GBA by Correlative Light-Electron Microscopy in Human Fibroblasts, Traffic 20(5): 346-356.
- Gential G.P.P., Hogervorst T.P., Tondini E., Graaff M.J. van de, Overkleeft H.S., Codée J.D.C., Marel G.A. van der, Ossendorp F. & Filippov D.V. (2019), Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7, Bioorganic and Medicinal Chemistry Letters 29(11): 1340-1344.
- Besse A., Besse L., Kraus M., Mendez-Lopez M., Bader J., Xin B., Bruin G. de, Maurits E., Overkleeft H.S. & Driessen C. (2019), Proteasome inhibition in multiple myeloma: head-to-head comparison of currently available proteasome inhibitors, Cell chemical biology 26(3): 340-351.
- Wang L., Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2019), Reagent Controlled Stereoselective Assembly of alpha-(1,3)-Glucans, European Journal of Organic Chemistry 2019(10): 1994-2003.
- Hansen T., Lebedel L., Remmerswaal W.A., Vorm S. van der, Wander D.P.A., Somers M., Overkleeft H.S., Filippov D.V., Désiré J., Mingot A., Bleriot Y., Marel G.A. van der, Thibaudeau S. & Codée J.D.C. (2019), Defining the SN1 Side of Glycosylation Reactions: Stereoselectivity of Glycopyranosyl Cations, ACS Central Science 5(5): 781-788.
- Moiola M., Crespi S., Memeo M., Collina S., Overkleeft H.S., Florea B.I. & Quadrelli P. (2019), Scope and Limitations of Boron Fluorescent Complexes from Stable Nitrile Oxides in ABPP Assays, ACS Omega 4(4): 7766-7774.
- Schröder S.P., Boer C. de, McGregor N.G.S., Rowland R.J., Moroz O., Blagova E., Reijngoud J., Arentshorst M., Osborn D., Morant M.D., Abbate E., Stringer M.A., Krogh K.B.R.M., Raich L., Rovira C., Wezel G.P. van, Berrin J.G., Florea B.I., Ram A.F.J., Codée J.D.C., Marel G.A. van der, Wu L., Wilson K.S., Overkleeft H.S. & Davies G.J. (2019), Dynamic and functional profiling of Xylan-degrading enzymes in aspergillus secretomes using activity-based probes, ACS Central Science 5(6): 1067-1078.
- Vorm S. van der, Hansen T., Hengst J.M.A. van, Overkleeft H.S., Marel G.A. van der & Codée J.D.C. (2019), Acceptor reactivity in glycosylation reactions, Chemical Society Reviews 48(17): 4688-4706.
- Mieremet A., Boiten W.A., Dijk R. van, Gooris G.S., Overkleeft H.S., Aerts J.M.F.G., Bouwstra J.A. & El Ghalbzouri A. (2019), Unravelling effects of relative humidity on lipid barrier formation in human skin equivalents, Archives of Dermatological Research 311(9): 679-689.
- Wu L., Armstrong Z., Schröder S.P., Boer C. de, Artola M., Aerts J.M.F.G., Overkleeft H.S. & Davies G.J. (2019), An overview of activity-based probes for glycosidases, Current Opinion in Chemical Biology 53: 25-36.
- Moiola M., Bova A., Crespi S., Memeo M.G., Mella M., Overkleeft H.S., Florea B.I. & Quadrelli P. (2019), Fluorescent Probes from Aromatic Polycyclic Nitrile Oxides: Isoxazoles versus Dihydro-1 lambda(3),3,2 lambda(4)-Oxazaborinines, ChemistryOpen 8(6): 770-780.
- Zhou X., Paushter D.H., Pagan M.D., Kim D., Nunez Santos M., Lieberman R.L., Overkleeft H.S., Sun Y., Smolka M.B. & Hu F. (2019), Progranulin deficiency leads to reduced glucocerebrosidase activity, 14(7): e212382.
- Zhang Q., Gimeno A., Santana D., Wang Z., Valdés-Balbin Y., Rodríguez-Noda L.M., Hansen T., Kong L., Shen M., Overkleeft H.S., Vérez-Bencomo V., Marel G.A. van der, Jiménez-Barbero J., Chiodo F. & Codée J.D.C. (2019), Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction, ACS Central Science 5(8): 1407-1416.
- Baggelaar M.P., Dulk H. den, Florea B.I., Fazio D., Bernab Ograve N., Raspa M., Janssen A.P.A., Scavizzi F., Barboni B., Overkleeft H.S., Maccarrone M. & Stelt M. van der (2019), ABHD2 inhibitor identified by activity-based protein profiling reduces acrosome reaction, ACS Chemical Biology 14(10): 2295-2304.
- Skorda A., Sklirou A.D., Sakellaropoulos T., Gianniou D.D., Kastritis E., Terpos E., Tsitsilonis O.E., Florea B.I., Overkleeft H.S., Dimopoulos M.A., Alexopoulos L.G. & Trougakos I.P. (2019), Non-lethal proteasome inhibition activates pro-tumorigenic pathways in multiple myeloma cells, Journal of Cellular and Molecular Medicine 23(12): 8010-8018.
- Lelieveld L.T., Mirzaian M., Kuo C.L., Artola Perez de Azanza M.E., Guimaraes da Lomba Ferraz M.J., Peter R.E.A., Akiyama H., Greimel P., Berg R.J.B.H.N. van den, Overkleeft H.S., Boot R.G., Meijer A. & Aerts J.M.F.G. (2019), Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish, Journal of Lipid Research 60(11): 1851-1867.
- Li R.E., Hogervorst T.P., Achilli S., Bruijns S.C., Arnoldus T., Vivès C., Wong C.C., Thépaut M., Meeuwenoord N.J., Elst H Van den, Overkleeft H.S., Marel G.A. van der, Filippov D.V., Vliet S.J. van, Fieschi F., Codee J.D.C. & Kooyk Y. van (2019), Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen, Frontiers in Chemistry 7: 650.
- Moro Chao D.H., Wang Y., Foppen E., Ottenhoff R., Roomen C. van, Parlevliet E.T., Eijk M.C. van, Verhoek M., Boot R.G., Marques A.R., Scheij S., Mirzaian M., Kooijman S., Jansen K., Wang D., Mergen C., Seeley R.J., Tschöp M.H., Overkleeft H.S., Rensen P.C.N., Kalsbeek A., Aerts J.M.F.G. & Yi C.X. (2019), The iminosugar AMP-DNM improves satiety and activates brown adipose tissue through GLP1, Diabetes 68(12): 2223-2234.
- Artola M., Hedberg C., Rowland R.J., Raich L., Kytidou K., Wu L., Schaaf A., Ferraz M.J., Marel G.A. van der, Codee J.D.C., Rovira C., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2019), Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease, Chemical Science 10(40): 9233-9243.
- Papanagnou E.D., Skorda A., Sklirou A., Terpos E., Kastritis E., Tsitsilonis O., Overkleeft H.S., Alexopoulos L., Dimopoulos M.A. & Trougakos I. (2019), Differential donor-, cell type- and drug-specific molecular responses to therapeutic proteasome inhibitors in Multiple Myeloma patients and cells, American Journal of Hematology 94(S2): S3-S33.
- Besse A., Besse L., Stolze S.C., Zaal E., Berkers C., Everts B., Phuyal S., Kraus M., Sobh A., Silzle T., Vulpe C., Farhan H., Overkleeft H.S. & Driessen C. (2019), Nelfinavir interacts with mitochondrial VDACs and disrupts oxidative phosphorylation in proteasome inhibitor resistant myeloma, Clinical Lymphoma, Myeloma and Leukemia 19(10): E125-E126.
- Jariwala P.B., Pellock S.J., Goldfarb D., Cloer E.W., Artola M., Simpson J.B., Bhatt A.P., Walton W.G., Roberts L.R., Major M.B., Davies G.J., Overkleeft H.S. & Redinbo M.R. (2019), Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling, ACS Chemical Biology 15(1): 217-225.
- Aerts J.M.F.G., Kuo C.L., Lelieveld L.T., Boer D.E.C., Lienden M.J.C. van der, Overkleeft H.S. & Artola M. (2019), Glycosphingolipids and lysosomal storage disorders as illustrated by gaucher disease, Current Opinion in Chemical Biology 53: 204-215.
- Mendez M., Besse A., Besse L., Florea B.I., Christian Z., Overkleeft H.S. & Driessen C. (2019), Proteasome inhibition by Carfilzomib, but not by Bortezomib, induces a specific, proteasome subunit-dependent impairment in cardiac contractility, Clinical Lymphoma, Myeloma and Leukemia 19(10): E119.
- Steverding D., Rushworth S.A., Florea B.I. & Overkleeft H.S. (2019), Trypanosoma brucei: Inhibition of cathepsin L is sufficient to kill bloodstream forms, Molecular and Biochemical Parasitology 235: 111246.
- Kuo C.L., Kallemeijn W.W., Lelieveld L.T., Mirzaian M., Zoutendijk I., Vardi A., Futerman A.H., Meijer A.H., Spaink H.P., Overkleeft H.S., Aerts J.M.F.G. & Artola Perez de Azanza M.E. (2019), In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity‐based protein profiling, FEBS Journal 286(3): 584-600.
- Koenders S.T.A., Wijaya L.S., Erkelens M.N., Bakker A.T., Noord V.E. van der, Rooden E.J. van, Burggraaff L., Putter P.C., Botter E., Wals K., Elst H. van den, Dulk H. den, Florea B.I., Water B. van de, Westen G.J.P. van, Mebius R.E., Overkleeft H.S., Le Dévédec S.E. & Stelt M. van der (2019), Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells, ACS Central Science 5(12): 1965-1974.
- Vocadlo D. & Overkleeft H.S. (2019), A round up on some of the latest in the chemistry and biology of carbohydrates and carbohydrate-processing enzymes, Current Opinion in Chemical Biology 53(2019): A1-A3.
- Esbroeck A.C.M. van, Kantae V., Di X., Wel T. van der, Dulk J. den, Stevens A.F., Singh S., Bakker A.T., Florea B.I., Stella N., Overkleeft H.S., Hankemeier T. & Stelt M. van der (2019), Identification of alpha,beta-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells, Frontiers in Molecular Neuroscience 12: 286.
- Esbroeck A.C.M. van, Kantae V., Di X., Wel T. van der, Dulk J. den, Stevens A.F., Singh S., Bakker A.T., Florea B.I., Stella N., Overkleeft H.S., Hankemeier T. & Stelt M. van der (2019), Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells, Frontiers in Molecular Neuroscience 12: 286.
- Steverding D., Florea B.I. & Overkleeft H.S. (2019), Trypanosoma brucei: β2-selective proteasome inhibitors do not block the proteasomal trypsin-like activity but are trypanocidal, Molecular and Biochemical Parasitology 227: 1-4.
- Liu B., Mechelen J. van, Berg R.J.B.H.N. van den, Nieuwendijk A.M.C.H. van den, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2019), Synthesis of glycosylated 1-deoxynojirimycins starting from natural and synthetic disaccharides, European Journal of Organic Chemistry 2019(1): 118-129.
- Zhou J., Mock E.D., Martella A., Kantae V., Di X., Burggraaff L., Baggelaar M.P., Al-Ayed K., Bakker A., Florea B.I., Grimm S.H., Dulk H. den, Li C.T., Mulder L., Overkleeft H.S., Westen G.J.P. van, Hankemeier T. & Stelt M. van der (2019), Activity-based protein profiling identifies α-ketoamides as inhibitors for Phospholipase A2 Group XVI, ACS Chemical Biology 14(2): 164-169.
- Kuo C.L., Kallemeijn W.W., Lelieveld L.T., Mirzaian M., Zoutendijk I., Vardi A., Futerman A.H., Meijer A.H., Spaink H.P., Overkleeft H.S., Aerts J.M.F.G. & Artola M. (2019), In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling, FEBS Journal 286(3): 584-600.
- Grimm S.H., Gagestein B., Keijzer J.F., Liu N., Wijdeven R.H., Lenselink E.B., Tuin A.W., Nieuwendijk A.M.C.H. van den, Westen G.J.P. van, Boeckel C.A.A. van, Overkleeft H.S., Neefjes J. & Stelt M. van der (2019), Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors, Bioorganic & Medicinal Chemistry 27(5): 692-699.
- Artola Perez de Azanza M.E., Wouters S., Schröder S.P., Boer C. de, Chen Y., Petracca R., Nieuwendijk A.M.C.H. van den, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2019), Direct Stereoselective Aziridination of Cyclohexenols with 3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors, European Journal of Organic Chemistry 2019(6): 1397-1404.
- Xin B.T., Huber E.M., Bruin G. de, Heinemeyer W., Maurits E., Espinal C., Du Y., Janssens M., Weyburne E.S., Kisselev A.F., Florea B.I., Driessen C., Marel G.A., Groll M. & Overkleeft H.S. (2019), Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits, Journal of Medicinal Chemistry 62(3): 1626-1642.
- Gracht A.M.F. van der, Geus M.A.R. de, Camps M.G.M., Ruckwardt T.J., Sarris A.J.C., Bremmers J., Maurits E., Pawlak J.B., Posthoorn M.M., Bonger K.M., Filippov D.V., Overkleeft H.S., Robillard M.S., Ossendorp F. & Kasteren S.I. van (2018), Chemical control over T-cell activation in vivo using deprotection of trans-cyclooctene-modified epitopes, ACS Chemical Biology 13(6): 1569-1576.
- Kuo C.L., Meel H.M.M. van, Kytidou K., Kallemeijn W.W., Witte M., Overkleeft H.S., Artola Pérez de Azanza M.E. & Aerts J.M.F.G. (2018), Activity-Based Probes for Glycosidases: Profiling and Other Applications. In: Imperiali B. (red.), Chemical Glycobiology Part B. Monitoring Glycans and their Interactions. Methods in Enzymology nr. 598: Elsevier: Monograph Series. 217-235.
- Liu Q., Kistemaker H.A.V., Bhogaraju S., Dikic I., Overkleeft H.S., Marel G.A. van der, Ovaa H., Heden van Noort G.J. van der & Filippov D.V. (2018), A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins, Angewandte Chemie (International Edition) 57(6): 1659-1662.
- Basler M., Maurits E., Bruin G. de, Koerner J., Overkleeft H.S. & Groettrup M. (2018), Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome, British Journal of Pharmacology 175(1): 38-52.
- Ongay S., Langelaar-Makkinje M., Stoop M.P., Liu N., Overkleeft H.S., Luider T.M., Groothuis G.M.M. & Bischoff R. (2018), Cleavable crosslinkers as tissue fixation reagents for proteomic analysis, ChemBioChem 19(7): 736-743.
- Soethoudt M., Stolze S.C., Westphal M.V., Stralen L. van, Martella A., Rooden E.J. van, Guba W., Varga Z.V., Deng H., Kasteren S.I. van, Grether U., IJzerman A.P., Pacher P., Carreira E.M., Overkleeft H.S., Heitman L.H., Ioan-Facsinay A. & Stelt M. van der (2018), A selective photoaffinity probe that enables assessment of cannabinoid CB2 receptor expression and ligand engagement in human cells, Journal of the American Chemical Society 140(19): 6067-6075.
- Rooden E.J. van, Florea B.I., Deng H., Baggelaar M.P., Esbroeck A.C.M. van, Zhou J., Overkleeft H.S. & Stelt M. van der (2018), Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification, Nature Protocols 13(4): 752-767.
- Schröder S.P., Wu L., Artola Perez de Azanza M.E., Hansen T., Offen W.A., Guimaraes da Lomba Ferraz M.J., Li K.-Y., Aerts J.M.F.G., Marel G.A. van der, Codee J.D.C., Davies G.J. & Overkleeft H.S. (2018), Gluco-1H-imidazole: A New Class of Azole-Type beta-Glucosidase Inhibitor, Journal of the American Chemical Society 140(15): 5045-5048.
- Schröder S.P., Kallemeijn W.W., Debets M.F., Hansen T., Sobala L.F., Hakki Z., Williams S.J., Beenakker T.J.M., Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C., Davies G.J. & Overkleeft H.S. (2018), Spiro-epoxyglycosides as activity-based probes for glycoside hydrolase family 99 endomannosidase/endomannanase, Chemistry: a European Journal 24(39): 9983-9992.
- Wang L., Overkleeft H.S., Marel G.A. van der & Codée J.D.C. (2018), Reagent Controlled Stereoselective assembly of alpha-(1-3)-Glucans, Journal of the American Chemical Society 140(13): 4632–4638.
- Rugen M.D., Vernet M.M.J.L., Hantouti L., Soenens A., Andriotis V.M.E., Rejzek M., Brett P., Berg R.J.B.H.N. van den, Aerts J.M.F.G., Overkleeft H.S. & Field R.A. (2018), A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals, Scientific Reports 8: 16421.
- Downey-Kopyscinski S., Daily E.W., Gautier M., Bhatt A., Florea B.I., Mitsiades C.S., Richardson P.G., Driessen C., Overkleeft H.S. & Kisselev A.F. (2018), An inhibitor of proteasome beta 2 sites sensitizes myeloma cells to immunoproteasome inhibitors, Blood Advances 2(19): 2443-2451.
- Besse A., Stolze S.C., Rasche L., Weinhold N., Morgan G.J., Kraus M., Bader J., Overkleeft H.S., Besse L. & Driessen C. (2018), Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma, Leukemia 32(2): 391-401.
- Rooden E.J. van, Esbroeck A.C.M. van, Baggelaar M.P., Deng H., Florea B.I., Rosa Alcalde Marques A., Ottenhoff R., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Stelt M. van der (2018), Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain, Frontiers in Neuroscience 12: 440.
- Eising S., Xin B., Kleinpenning F., Heming J.J.A., Florea B.I., Overkleeft H.S. & Bonger K.M. (2018), Coordination-Assisted Bioorthogonal Chemistry: Orthogonal Tetrazine Ligation with Vinylboronic Acid and a Strained Alkene, ChemBioChem 19(15): 1648-1652.
- Rooden E.J. van, Kohsiek M.J.J., Kreekel R., Esbroeck A.C.M. van, Nieuwendijk A.M.C.H. van den, Janssen A.P.A., Berg R.J.B.H.N. van den, Overkleeft H.S. & Stelt M. van der (2018), Design and Synthesis of Quenched Activity-based Probes for Diacylglycerol Lipase and alpha,beta-Hydrolase Domain Containing Protein 6, Chemistry - An Asian Journal 13(22): 3491-3500.
- Ben Bdira F., Artola Perez de Azana M.E., Overkleeft H.S., Ubbink M. & Aerts J.M.F.G. (2018), Distinguishing the differences in beta-glycosylceramidase folds, dynamics, and actions informs therapeutic uses, Journal of Lipids 59(12): 2262-2276.
- Tol M.J., Lienden M.J.C. van der, Gabriel T.L., Hagen J.J., Scheij S., Veenendaal T., Klumperman J., Donker-Koopman W.E., Verhoeven A.J., Overkleeft H.S., Aerts J.M.F.G., Argmann C.A. & Eijk M.C. van (2018), HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution, Autophagy 14(3): 437-449.
- Vorm S. van der, Hengst J.M.A. van, Bakker M.H.E., Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2018), Mapping the Relationship between Glycosyl Acceptor Reactivity and Glycosylation Stereoselectivity, Angewandte Chemie (International Edition) 57(27): 8240-8244.
- Husaini A.M., Morimoto K., Chandrasekar B., Kelly S., Kaschani F., Palmero D., Jiang J., Kaiser M., Ahrazem O., Overkleeft H.S. & Hoorn R.A.L. van der (2018), Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants, Plant Physiology 177(1): 24-37.
- Kytidou K., Beekwilder J., Artola M., Meel E. van, Wilbers R.H.P., Moolenaar G.F., Goosen N., Ferraz M.J., Katzy R., Voskamp P., Florea B.I., Hokke C.H., Overkleeft H.S., Schots A., Bosch D., Pannu N. & Aerts J.M.F.G. (2018), Nicotiana benthamiana α-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease, Journal of Biological Chemistry 293(26): 10042-10058.
- Bakkum T., Leeuwen T. van, Sarris A.J.C., Elsland D.M. van, Poulcharidis D., Overkleeft H.S. & Kasteren S.I. van (2018), Quantification of Bioorthogonal Stability in Immune Phagocytes Using Flow Cytometry Reveals Rapid Degradation of Strained Alkynes, ACS Chemical Biology 13(5): 1173-1179.
- Engelsma S.B., Ende T.C. van den, Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2018), Reaction Rates of Various N-Acylenamines in the Inverse-Electron-Demand Diels-Alder Reaction, European Journal of Organic Chemistry (20-21): 2587-2591.
- Es D. van der, Berni F., Hogendorf W.F.J., Meeuwenoord N., Laverde D., Diepen A. van, Overkleeft H.S., Filippov D.V., Hokke C.H., Huebner J., Marel G.A. van der & Codée J.D.C. (2018), Streamlined Synthesis and Evaluation of Teichoic Acid Fragments, Chemistry: a European Journal 24(16): 4014-4018.
- Beenakker T.J.M., Wander D.P.A., Codée J.D.C., Aerts J.M.F.G., Marel G.A. van der & Overkleeft H.S. (2018), Synthesis of Carba-Cyclophellitols: a New Class of Carbohydrate Mimetics, European Journal of Organic Chemistry 2018(20-21): 2504-2517.
- Voorneveld J., Rack J.G.M., Ahel I., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2018), Synthetic alpha- and beta-Ser-ADP-ribosylated Peptides Reveal alpha-Ser-ADPr as the Native Epimer, Organic Letters 20(13): 4140-4143.
- Basler M., Lindstrom M.M., LaStant J.J., Bradshaw J.M., Owens T.D., Schmidt C., Maurits E., Tsu C., Overkleeft H.S., Kirk C.J., Langrish C.L. & Groettrup M. (2018), Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity, EMBO Reports 19(12): e46512.
- Sarris A.J.C., Hansen T., Geus M.A.R. de, Maurits E., Doelman W., Overkleeft H.S., Codée J.D.C., Filippov D.V. & Kasteren S.I. van (2018), Fast and pH-Independent Elimination of trans-Cyclooctene by Using Aminoethyl-Functionalized Tetrazines, Chemistry: a European Journal 24(68): 18075-18081.
- Artola M., Kuo C.L., McMahon S.A., Oehler V., Hansen T., Lienden M.J.C. van der, He X., Elst H. van den, Florea B.I., Kermode A.R., Marel G.A. van der, Gloster T.M., Codée J.D.C., Overkleeft H.S. & Aerts J.M.F.G. (2018), New Irreversible alpha-l-Iduronidase Inhibitors and Activity-Based Probes, Chemistry: a European Journal 24(71): 19081-19088.
- Breen I.Z., Artola Perez de Azanza M.E., Wu L., Beenakker T.J.M., Offen W.A., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2018), Competitive and covalent inhibitors of human lysosomal retaining exoglucosidases. In: Maccarrone M. (red.), eLS: Wiley Online Library.
- Rooden E.J. van, Bakker A.T., Overkleeft H.S. & Stelt M. van der (2018), Activity-based protein profiling. In: , eLS: John Wiley & Sons, Ltd..
- Marques A.R., Willems L.I., Herrera Moro D., Florea B.I., Scheij S., Ottenhof R., Roomen C. van, Verhoek M., Nelson J.K., Kallemeijn W.W., Biela-Banas A., Martin O.R., Cachón-González M.B., Kim N.N., Cox T.M., Boot R.G., Overkleeft H.S. & Aerts J.M.F.G. (2017), A specific activity-based probe to monitor family GH59 galactosylceramidase - the enzyme deficient in Krabbe disease, ChemBioChem 18(4): 402-412.
- Es D. van der, Hogendorf W.F.J., Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2017), Teichoic Acids: Synthesis and Applications, Chemical Society Reviews 46: 1464-1482.
- Hagen B., Ali S., Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2017), Mapping the reactivity and selectivity of 2-azidofucosyl donors for the efficient assembly of N-acetyl fucosamine containing bacterial oligosaccharides, Journal of Organic Chemistry (JOC) 82(2): 848–868.
- Vorm S. van der, Hansen T., Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2017), The Influence of Acceptor Nucleophilicity on the Glycosylation Reaction Mechanism, Chemical Science 2017(8): 1867-1875.
- Deng H., Kooijman S., Nieuwendijk A.M.C.H. van den, Ogasawara D., Wel T. van der, Dalen F. van, Baggelaar M.P., Janssen F.J., Berg R.J.B.H.N. van der, Dulk J. den, Cravatt B.F., Overkleeft H.S., Rensen P.C. & Stelt M. van der (2017), Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding, Journal of Medicinal Chemistry 60(1): 428-440.
- Esbroeck A.C.M. van, Janssen A.P.A., Cognetta III A.B., Ogasawara D., Shpak G., Kroeg M. van der, Kantae V., Baggelaar M.P., Vrij F.M.S. de, Deng H., Allara M., Fezza F., Lin Z., Wel T. van der, Soethoudt M., Mock E.D., Dulk H. den, Baak I.L., Florea B.I., Hendriks G., Petrocellis L. de, Overkleeft H.S., Hankemeier T., Zeeuw C.I. de, Di Marzo V., Maccarrone M., Cravatt B.F., Kushner S.A. & Stelt M. van der (2017), Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474, Science 356(6342): 1084-1087.
- Baggelaar M.P., Esbroeck A.C.M. van, Rooden E.J. van, Florea B.I., Overkleeft H.S., Marsicano G., Chaouloff F. & Stelt M. van der (2017), Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases, ACS Chemical Biology 12(3): 852-861.
- Deng H., Wel T. van der, Berg R.J.B.H.N. van den, Nieuwendijk A.M.C.H. van den, Janssen F.J., Baggelaar M.P., Overkleeft H.S. & Stelt M. van der (2017), Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-alpha and ABHD6 inhibitors, MEDCHEMCOMM 8(5): 982-988.
- Kytidou K., Beenakker T.J.M., Westerhof L.B., Hokke C.H., Moolenaar G.F., Goosen N., Mirzaian M., Guimaraes da Lomba Ferraz M.J., Geus M.A.R. de, Kallemeijn W.W., Overkleeft H.S., Boot R.G., Schots A., Bosch D. & Aerts J.M.F.G. (2017), Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease, Frontiers in Plant Science 8: 1026.
- Mirzaian M., Wisse P., Guimaraes da Lomba Ferraz M.J., Marques A.R.A., Gaspar P., Oussoren S.V., Kytidou K., Codée J.D.C., Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2017), Simultaneous quantitation of sphingoid bases by UPLC-ESI-MS/MS with identical C-13-encoded internal standards, Clinica Chimica Acta 466: 178-184.
- Rijssel E.R. van, Janssen A.P.A., Males A., Davies G.J., Marel G.A. van der, Overkleeft H.S. & Codee J.D.C. (2017), Conformational behaviour of Azasugars based on mannuronic acid, ChemBioChem 18(13): 1297-1304.
- Lahav D., Liu B., Berg R.J.B.H.N. van den, Nieuwendijk A.M.C.H. van den, Wennekes T., Ghisaidoobe A.T., Breen I., Ferraz M.J., Kuo C.L., Wu L., Geurink P.P., Ovaa H., Marel G.A. van der, Stelt M. van der, Boot R.G., Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2017), A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase, Journal of the American Chemical Society 138(40): 14192-14197.
- Narhe B.D., Breman A.C., Padwal J., Vandenput D.A.L., Scheidt J.M., Benningshof J.C.J., Marel G.A. van der, Overkleeft H.S., Stelt M. van der & Filippov D.V. (2017), Piperidine and octahydropyrano[3,4-c] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory, Bioorganic & Medicinal Chemistry 25(19): 5160-5170.
- Petracca R., Romeo E., Baggelaar M.P., Artola M., Pontis S., Ponzano S., Overkleeft H.S., Stelt M. van der & Piomelli D. (2017), Novel activity-based probes for N-acylethanolamine acid amidase, Chemical Communications 53(86): 11810-11813.
- Smeden J. van, Dijkhoff I.M., Helder R.W.J., Al-Khakany H., Boer D.E.C., Schreuder A., Kallemeijn W.W., Absalah S., Overkleeft H.S., Aerts J.M.F.G. & Bouwstra J.A. (2017), In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling, Journal of Lipid Research 58(12): 2299-2309.
- Ben Bdira F., Kallemeijn W.W., Oussoren S.V., Scheij S., Bleijlevens B., Florea B.I., Roomen C.P.A.A. van, Ottenhoff R., Kooten M.J.F.M. van, Walvoort M.T.C., Witte M.D., Boot R.G., Ubbink M., Overkleeft H.S. & Aerts J.M.F.G. (2017), Stabilization of Glucocerebrosidase by Active Site Occupancy, ACS Chemical Biology 12(7): 1830-1841.
- Artola Perez de Azanza M.E., Wu L., Guimaraes da Lomba Ferraz M.J., Kuo C.L., Raich L., Breen I.Z., Offen W.A., Codee J.D.C., Marel G.A. van der, Rovira C., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2017), 1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor, ACS Central Science 3(7): 784-793.
- Wu L., Jiang J., Jin Y., Kallemeijn W.W., Kuo C.-L., Artola M., Dai W., Elk C. van, Eijk M. van, Marel G.A. van der, Codee J.D.C., Florea B.I., Aerts J.M.F.G., Overkleeft H.S. & Davies G.J. (2017), Activity-based probes for functional interrogation of retaining beta-glucuronidases, Nature Chemical Biology 13(8): 867-873.
- Beenakker T.J.M., Wander D.P.A., Offen W.A., Artola Perez de Azanza M.E., Raich L., Guimaraes da Lomba Ferraz M.J., Li K.Y., Houben J.H.P.M., Rijssel E.R. van, Hansen T., Marel G.A. van der, Codee J.D.C., Aerts J.M.F.G., Rovira C., Davies G.J. & Overkleeft H.S. (2017), Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors, Journal of the American Chemical Society 139(19): 6534-6537.
- Jiang J., Kuo C.L., Wu L., Franke C., Kallemeijn W.W., Florea B.I., Meel H.M.M. van, Marel G.A. van der, Codee J.D.C., Boot R.G., Davies G.J., Overkleeft H.S. & Aerts J.M.F.G. (2017), Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes", ACS Central Science 3(6): 673.
- Kallemeijn W.W., Scheij S., Hoogendoorn S., Witte M.D., Herrera Moro Chao D., Roomen C.P.A.A. van, Ottenhoff R., Overkleeft H.S., Boot R.G. & Aerts J.M.F.G. (2017), Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes, PLoS ONE 12(2): e0170268.
- Schröder S.P., Sande J.W. van de, Kallemeijn W.W., Kuo C.L., Artola Perez de Azanza M.E., Rooden E.J. van, Jiang J., Beenakker T.J.M., Florea B.I., Offen W.A., Davies G.J., Minnaard A.J., Aerts J.M.F.G., Codee J.D.C., Marel G.A. van der & Overkleeft H.S. (2017), Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines, Chemical Communications 53(93): 12528-12531.
- Bruin G. de, Rooden E.J. van, Ward D., Wesseling C.M.J., Nieuwendijk A.M.C.H. van den, Boeckel C.A.A. van, Driessen C., Kisselev A.F., Florea B.I., Stelt M. van der & Overkleeft H.S. (2017), Asymmetric synthesis of lysine analogues with reduced basicity, and their incorporation into proteasome inhibitors, European Journal of Organic Chemistry 2017(39): 5921-5934.
- Zhang Q., Howell P.L., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codee J.D.C. (2017), Chemical synthesis of guanosine diphosphate mannuronic acid (GDPManA) and its C-4-O-methyl and C-4-deoxy congeners, Carbohydrate Research 450: 12-18.
- Volbeda A.G., Mechelen J. van, Meeuwenoord N., Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2017), Cyanopivaloyl Ester in the Automated Solid-Phase Synthesis of Oligorhamnans, Journal of Organic Chemistry (JOC) 82(24): 12992-13002.
- Baker Y.R., Hodgkinson J.T., Florea B.I., Alza E., Galloway W.R.J.D., Grimm L., Geddis S.M., Overkleeft H.S., Welch M. & Spring D.R. (2017), Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes, Chemical Science 8(11): 7403-7411.
- Tsakiri E.N., Terpos E., Papanagnou E.D., Kastritis E., Brieudes V., Halabalaki M., Bagratuni T., Florea B.I., Overkleeft H.S., Scorrano L., Skaltsounis A.L., Dimopoulos M.A. & Trougakos I.P. (2017), Milder degenerative effects of Carfilzomib &ITvs&IT. Bortezomib in the Drosophila model: a link to clinical adverse events, Scientific Reports 7: 17802.
- Liu Q., Kistemaker H.A.V., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2017), Synthesis of ribosyl-ribosyl-adenosine-5 ',5 '',5'''(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose), Chemical Communications 53(74): 10255-10258.
- Aerts J.M.F.G., Guimaraes da Lomba Ferraz M.J., Mirzaian M., Gaspar P., Oussoren S.V., Wisse P., Kuo C.L., Lelieveld L.T., Kytidou K., Hazeu M.D., Boer D.E.C., Meijer R., Lienden M.J.C. van der, Herrera D., Gabriel T.L., Aten J., Overkleeft H.S., Eijk M.C. van, Boot R.G. & Rosa Alcalde Marques A. (2017), Lysosomal Storage Diseases. For Better or Worse: Adapting to Defective Lysosomal Glycosphingolipid Breakdown. In: , eLS. eLS: John Wiley & Sons, Ltd.. 1-13.
- Gubbens J., Wu C., Zhu H., Filippov D.V., Florea B.I., Rigali S., Overkleeft H.S. & Wezel G.P. van (2017), Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp MBT76, ACS Chemical Biology 12(11): 2756-2766.
- Kasteren S.I. van, Florea B.I. & Overkleeft H.S. (2017), Activity-Based Protein Profiling: From Chemical Novelty to Biomedical Stalwart. In: Florea B.I. & Overkleeft H.S. (red.), Activity-based Proteomics: Methods and Protocols. Methods in Molecular Biology. New York: Humana Press. 1-8.
- Overkleeft H.S. & Florea B.I. (2017), Activity-Based Proteomics: Methods and Protocols. Methods in Molecular Biology nr. 1491. New York: Humana Press.
- Hagen B., Dijk J.H.M. van, Zhang Q., Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2017), Synthesis of the Staphylococcus aureus Strain M Capsular Polysaccharide Repeating Unit, Organic Letters 19(10): 2514-2517.
- Zhang Qingju, Overkleeft Herman S., Van der Marel Gijsbert A. & Codee Jeroen D.C. (2017), Synthetic zwitterionic polysaccharides, Current Opinion in Chemical Biology 40: 95-101.
- Widjaja C.E., Olvera J.G., Metz P.J., Phan A.T., Savas J.N., Bruin G. de, Leestemaker Y., Berkers C.R., Jong A. de, Florea B.I., Fisch K., Lopez J., Kim S.H., Garcia D.A., Searles S., Bui J.D., Chang A.N., Yates J.R.III, Goldrath A.W., Overkleeft H.S., Ovaa H. & Chang J.T. (2017), Proteasome activity regulates CD8(+) T lymphocyte metabolism and fate specification, Journal of Clinical Investigation 127(10): 3609-3623.
- Paniagua Soriano G., Overkleeft H.S. & Florea B.I. (2017), Two-Step Activity-Based Protein Profiling with the Proteasome System as Model of Study. In: Overkleeft H.S. & Florea B.I. (red.), Activity-based Proteomics: Methods and Protocols. Methods in Molecular Biology nr. 1491. New York: Humana Press. 205-215.
- Elsland D.M. van, Bos E., Pawlak J.B., Overkleeft H.S., Koster A.J. & Kasteren S.I. van (2017), Correlative light and electron microscopy reveals discrepancy between gold and fluorescence labelling, Journal of Microscopy 267(3): 309-317.
- Engelsma S.B., Meeuwenoord N.J., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2017), Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates, Angewandte Chemie (International Edition) 56(11): 2955-2959.
- Vorm S. van der, Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2017), Stereoselectivity of Conformationally Restricted Glucosazide Donors, Journal of Organic Chemistry (JOC) 82(9): 4793-4811.
- Prely L., Klein T., Geurink P.P., Paal K., Overkleeft H.S. & Bischoff R. (2017), Activity-Dependent Photoaffinity Labeling of Metalloproteases. In: Overkleeft H.S. & Florea B.I. (red.), Activity-based Proteomics: Methods and Protocols. Methods in Molecular Biology nr. 1491. New York: Humana Press. 103-111.
- Besse A., Stolze S.C., Rasche L., Weinhold N., Morgan G.J., Kraus M., Bader J., Overkleeft H.S., Besse L. & Driessen C. (2017), Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma, Leukemia 32: 391-401.
- Overkleeft H.S. & Seeberger P.H. (2017), Chemoenzymatic Synthesis of Glycans and Glycoconjugates. In: Varki A., Cummins R.D., Esko J.D., Stanley P., Hart G.W., Aebi M., Darvill A.G., Kinoshita T., Packer N.H., Prestergard J.H., Schnaar R.L. & Seeberger P.H. (red.), Essentials of Glycobiology. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press. Chapter 54.
- Seeberger P.H. & Overkleeft H.S. (2017), Chemical Synthesis of Glycans and Glycoconjugates. In: Varki A., Cummins R.D., Esko J.D., Stanley P., Hart G.W., Aebi M., Darvill A.G., Kinoshita T., Packer N.H., Prestergard J.H., Schnaar R.L. & Seeberger P.H. (red.), Essentials of Glycobiology. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press. Chapter 53.
- Weyburne E.S., Wilkins O.M., Sha Z., Williams D.A., Pletnev A.A., Bruin G. de, Overkleeft H.S., Goldberg A.L., Cole M.D. & Kisselev A.F. (2017), Inhibition of the Proteasome beta 2 Site Sensitizes Triple-Negative Breast Cancer Cells to beta 5 Inhibitors and Suppresses Nrf1 Activation, Cell chemical biology 24(2): 218-230.
- Kovacs J., Poor P., Kaschani F., Chandrasekar B., Hong T.N., Misas-Villamil J.C., Xin B.T., Kaiser M., Overkleeft H.S., Tari I. & Hoorn R.A.L. van der (2017), Proteasome Activity Profiling Uncovers Alteration of Catalytic beta 2 and beta 5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots, Frontiers in Plant Science 8: 107.
- Misas-Villamil J.C., Burgh A.M. van der, Grosse-Holz F., Bach-Pages M., Kovacs J., Kaschani F., Schilasky S., Emon A.E.K., Ruben M., Kaiser M., Overkleeft H.S. & Hoorn R.A.L. van der (2017), Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections, The Plant Journal 90(2): 418-430.
- Driessen C., Kraus M., Joerger M., Rosing H., Bader J., Hitz F., Berset C., Xyrafas A., Hawle H., Berthod G., Overkleeft H.S., Sessa C., Huitema A., Pabst T., Moos R. von der, Hess D. & Mey U.J. (2016), Treatment with the HIV protease inhibitor Nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08), Haematologica 101(2): 346-355.
- Stolze S.C., Liu N., Wijdeven R.H., Tuin A.W., Nieuwendijk A.M. van den, Florea B.I., Stelt M. van der, Marel G.A. van der, Neefjes J.J. & Overkleeft H.S. (2016), Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes, Molecular Biosystems 12(6): 1809-1817.
- Kammerl I.E., Dann A., Mossina A., Brech D., Lukas C., Vosyka O., Nathan P., Conlon T.M., Wagner D.E., Overkleeft H.S., Prasse A., Rosas I.O., Straub T., Krauss-Etschmann S., Königshoff M., Preissler G., Winter H., Lindner M., Hatz R., Behr J., Heinzelmann K., Yildirim A.Ö., Noessner E., Eickelberg O. & Meiners S. (2016), Impairment of Immunoproteasome Function by Cigarette Smoke and in Chronic Obstructive Pulmonary Disease, American Journal of Respiratory and Critical Care Medicine 193(11): 1230-1241.
- Ogasawara D., Deng H., Viader A., Baggelaar M.P., Breman A., Dulk H. den, Nieuwendijk A.M.C.H. van den, Soethoudt M., Wel T. van der, Zhou J., Overkleeft H.S., Sanchez-Alavez M., Mori S., Nguyen W., Conti B., Liu X., Chen Y., Liu Q., Cravatt B.F. & Stelt M. van der (2016), Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition, Proceedings of the National Academy of Sciences 113(1): 26-33.
- Kwan D.H., Jin Y., Jiang J., Chen H.M., Kötzler M.P., Overkleeft H.S., Davies G.J. & Withers S.G. (2016), Chemoenzymatic synthesis of 6-phospho-cyclophellitol as a novel probe of 6-phospho-β-glucosidases, FEBS Letters 590(4): 461-468.
- Xin B.T., Bruin G. de, Huber E.M., Besse A., Florea B.I., Filippov D.V., Marel G.A. van der, Kisselev A.F., Stelt M. van der, Driessen C., Groll M. & Overkleeft H.S. (2016), Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes, Journal of Medicinal Chemistry 59(15): 7177-7187.
- Willems M.M.J.H.P., Zom G.G., Meeuwenoord N.J., Khan S., Ossendorp F.A., Overkleeft H.S., Marel G.A. van der, Filippov D.V. & Codée J.D.C. (2016), Lipophilic muramyl dipeptide-antigen conjugates as immunostimulating agents, ChemMedChem 11(2): 190-198.
- Nabuurs R.J.A., Kapoerchan V.V., Metaxas A., Hafith S., Backer M. de, Welling M.M., Jiskoot W., Nieuwendijk A.M.C.H. van den, Windhorst A.D., Overkleeft H.S., Buchem M.A. van, Overhand M. & Weerd L. van der (2016), Bis-pyridylethenyl benzene as novel backbone for amyloid-beta binding compounds, Bioorganic & Medicinal Chemistry 24(23): 6139-6148.
- Widjaja C.E., Metz P.J., Bruin G. de, Leestemaker Y., Savas J.N., Phan A.T., Goldrath A.W., Yates J.R., Florea B.I., Overkleeft H.S., Ovaa H. & Chang J.T. (2016), Proteasome degradative activity regulates CD8(+) T lymphocyte metabolism and fate specification, Journal of Immunology 196(1): 133.12.
- Bruin G. de, Xin B.T., Kraus M., Stelt M. van der, Marel G.A. van der, Kisselev A.F., Driessen C., Florea B.I. & Overkleeft H.S. (2016), A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities, Angewandte Chemie (International Edition) 55(13): 4199-4203.
- Xin B.T., Bruin G. de, Plomp J.W., Florea B.I., Marel G.A. van der & Overkleeft H.S. (2016), Incorporation of the Constrained Peptidomimetic, 5-Methylpyridin-2-one into Peptide Vinyl Sulfones and Peptide Epoxy Ketones is Detrimental for Proteasome Inhibition, European Journal of Organic Chemistry (6): 1132-1144.
- Bruin G. de, Xin B.T., Florea B.I. & Overkleeft H.S. (2016), Proteasome Subunit Selective Activity-Based Probes Report on Proteasome Core Particle Composition in a Native Polyacrylamide Gel Electrophoresis Fluorescence-Resonance Energy Transfer Assay, Journal of the American Chemical Society 138(31): 9874-9880.
- Bruin G. de, Mock E.D., Hoogendoorn S., Nieuwendijk A.M.C.H. van den, Mazurek J., Marel G.A. van der, Florea B.I. & Overkleeft H.S. (2016), Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib, Chemical Communications 52(21): 4064-4067.
- Xin B.T., Schimmack G., Du Y., Florea B.I., Marel G.A. van der, Driessen C., Krappmann D. & Overkleeft H.S. (2016), Development of new Malt1 inhibitors and probes, Bioorganic & Medicinal Chemistry 24(15): 3312-3329.
- Banno A., Garcia D.A., Baarsel E.D. van, Metz P.J., Fisch K., Widjaja C.E., Kim S.H., Lopez J., Chang A.N., Geurink P.P., Florea B.I., Overkleeft H.S., Ovaa H., Bui J.D., Yang J. & Chang J.T. (2016), Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition, OncoTarget 7(16): 21527-21541.
- Mirzaian M., Wisse P., Ferraz M.J., Marques A.R., Gabriel T.L., Roomen C.P. van, Ottenhoff R., Eijk M. van, Codée J.D., Marel G.A. van der, Overkleeft H.S. & Aerts J.M. (2016), Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard, Clinica Chimica Acta 459: 36-44.
- Marques A.R., Mirzaian M., Akiyama H., Wisse P., Ferraz M.J., Gaspar P., Ghauharali-Van der Vlugt K., Meijer R., Giraldo P., Alfonso P., Irún P., Dahl M., Karlsson S., Pavlova E.V., Cox T.M., Scheij S., Verhoek M., Ottenhoff R., Roomen C.P. van, Pannu N.S., Van Eijk M., Dekker N., Boot R.G., Overkleeft H.S., Blommaart E., Hirabayashi Y. & Aerts J.M. (2016), Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases, 57: 451-463.
- Jiang J., Artola Perez de Azanza M.E., Beenakker T.J.M., Schröder S.P., Petracca R., Boer C. de, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2016), The synthesis of cyclophellitol-aziridine and its configurational and functional isomers, European Journal of Organic Chemistry 2016(22): 3671-3678.
- Pawlak J.B., Hos B.J., Graaff M.J. van de, Megantari O.A., Meeuwenoord N., Overkleeft H.S., Filippov D.V., Ossendorp F. & Kasteren S.I. van. (2016), The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes, ACS Chemical Biology : .
- Gential G.P., Ho N.I., Chiodo F., Meeuwenoord N., Ossendorp F., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2016), Synthesis and evaluation of fluorescent Pam3Cys peptide conjugates, Bioorganic and Medicinal Chemistry Letters 26(15): 3641-5.
- Es D. van der, Groenia N.A., Laverde D., Overkleeft H.S., Huebner J., Marel G.A. van der & Codee J.D.C. (2016), Synthesis of E. faecium wall teichoic acid fragments, Bioorganic & Medicinal Chemistry 24(17): 3893-3907.
- Kistemaker H.A., Nardozza A.P., Overkleeft H.S., Marel G.A. van der, Ladurner A.G. & Filippov D.V. (2016), Synthesis and macrodomain binding of mono-ADP-ribosylated peptides, Angewandte Chemie (International Edition) 55(36): 10634-8.
- Zhang Q., Rijssel E.R. van, Overkleeft H.S., Marel G.A. van der & Codée J.D.C. (2016), On the Reactivity of Gulose and Guluronic Acid Building Blocks in the Context of Alginate Assembly, European Journal of Organic Chemistry 2016(14): 2393-2397.
- Schroder S., Petracca R., Minnee H., Artola M., Aerts J.M.F.G., Codée J.D.C., Marel G.A. van der & Overkleeft H.S. (2016), A Divergent Synthesis of L-arabino- and D-xylo-configured Cyclophellitol Epoxides and Aziridines, European Journal of Organic Chemistry : .
- Elsland D.M. van, Bos E., Boer W. de, Overkleeft H.S., Koster A.J. & Kasteren S.I. van (2016), Detection of bioorthogonal groups by correlative light and electron microscopy allows imaging of degraded bacteria in phagocytes, Chemical Science 7(1): 752-758.
- Volbeda A.G., Reintjens N.R.M., Overkleeft H.S., Marel G.A. van der & Codée J.D.C. (2016), The Cyanopivaloyl Ester: A Protecting Group in the Assembly of Oligorhamnans, European Journal of Organic Chemistry 2016(31): 5282-5293.
- Caner S., Zhang X., Jiang J., Chen H.-M., Nguyen N.T., Overkleeft H.S., Brayer G.D. & Withers S.G. (2016), Glucosyl epi-cyclophellitol allows mechanism-based inactivation and structural analysis of human pancreatic alpha-amylase, FEBS Letters 590(8): 1143-1151.
- Huber E.M., Heinemeyer W., Bruin G. de, Overkleeft H.S. & Groll M. (2016), A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta5i, The EMBO Journal 35: 2602-2613.
- Bhattarai S., Ghannam K., Krause S., Benveniste O., Marg A., Bruin G. de, Xin B.-T., Overkleeft H.S., Spuler S., Stenzel W. & Feist E. (2016), The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies, Journal of Autoimmunity 75: 118-129.
- Jian J., Zhao S., Tian Q.-Y., Liu H., Zhao Y., Chen W.-C., Grunig G., Torres P.A., Wang B.C., Zeng B., Pastores G., Tang W., Sun Y., Grabowski G.A., Kong M.X., Wang G., Chen Y., Liang F., Overkleeft H.S., Saunders-Pullman R., Chan G.L. & Liu C.-J. (2016), Association Between Progranulin and Gaucher Disease, EBioMedicine 11: 127-137.
- Spur E.M., Althof N., Respondek D., Klingel K., Heuser A., Overkleeft H.S. & Voigt A. (2016), Inhibition of chymotryptic-like standard proteasome activity exacerbates doxorubicin-induced cytotoxicity in primary cardiomyocytes, Toxicology 353: 34-47.
- Kallemeijn W.W., Scheij S., Voorn-Brouwer T.M., Witte M.D., Verhoek M., Overkleeft H.S., Boot R.G. & Aerts J.M. (2016), Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement, ChemBioChem 17(18): 1698-1704.
- Guimaraes da Lomba Ferraz M.J., Marques A.R., Appelman M.D., Verhoek M., Strijland A., Mirzaian M., Scheij S., Ouairy C.M.J., Lahav D., Wisse P., Overkleeft H.S., Boot R.G. & Aerts J.M.F.G. (2016), Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases, FEBS Letters 590(6): 716-725.
- Chen S., Kammerl I.E., Vosyka O., Baumann T., Yu Y., Wu Y., Irmler M., Overkleeft H.S., Beckers J., Eickelberg O., Meiners S. & Stoeger T. (2016), Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages, Cell Death & Differentiation 23(6): 1026-1037.
- Jiang J., Kuo C.L., Wu L., Franke C., Kallemeijn W.W., Florea B.I., Meel H.M.M. van, Marel G.A. van der, Codée J.D.C., Boot R.G., Davies G.J., Overkleeft H.S. & Aerts J.M.F.G. (2016), Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes, ACS Central Science 2(5): 351-358.
- Guimaraes da Lomba Ferraz M.J., Marques A.R.A., Gaspar P., Mirzaian M., Roomen C. van, Ottenhoff R., Alfonso P., Irún P., Giraldo P., Wisse P., Sá Miranda C., Overkleeft H.S. & Aerts J.M. (2016), Lyso-glycosphingolipid abnormalities in different murine models of lysosomal storage disorders, Molecular Genetics and Metabolism 117(2): 186–193.
- Ben Bdira F., Jiang J., Kallemeijn W.W., Haan A. de, Florea B.I., Bleijlevens B., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Ubbink M. (2016), Hydrophobic interactions contribute to conformational stabilization of endoglycoceramidase II by mechanism-based probes, Biochemistry 55(34): 4823-4835.
- Paeschke A., Possehl A., Klingel K., Voss M., Voss K., Kesphol M., Sauter M., Overkleeft H.S., Althof N., Garlanda C. & Voigt A. (2016), The immunoproteasome controls the availability of the cardio-protective pattern recognition molecule Pentraxin3, European Journal of Immunology 46(3): 619-633.
- Smid B.E., Ferraz M.J., Verhoek M., Mirzaian M., Wisse P., Overkleeft H.S., Hollak C.E. & Aerts J.M. (2016), Biochemical response to substrate reduction therapy versus enzyme replacement therapy in Gaucher disease type 1 patients, Orphanet Journal of Rare Diseases 11: 28.
- Paniagua Soriano G., Besse L., Li N., Kraus M., Besse A., Meeuwenoord N., Bader J., Everts B., Dulk H. den, Overkleeft H.S., Florea B.I. & Driessen C. (2016), Proteasome inhibibor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism, Leukemia 30: 2198-2207.
- Jian J., Tian Q.-Y., Hettinghouse A., Zhao S., Liu H., Wei J., Grunig G., Zhang W., Setchell K.D.R., Sun Y., Overkleeft H.S., Chan G.L. & Liu C.-J. (2016), Progranulin Recruits HSP70 to beta-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease, EBioMedicine 13: 212-224.
- Baumann T., Vosyka O., Florea B.I., Overkleeft H.S., Meiners S. & Kammerl I.E. (2016), Activity-based Pull-down of Proteolytic Standard and Immunoproteasome Subunits, Bio-protocol 6(24): e2073.
- Baggelaar M.P., Chameau P.J.P., Kantae V., Hummel J., Hsu K.L., Janssen F., Wel T. van der, Soethoudt M., Deng H., Den Dulk H., Allara M., Florea B.I., Di Marzo V., Wadman W.J., Kruse C.G., Overkleeft H.S., Hankemeier T., Werkman T.R., Cravatt B.F. & Stelt M. van der (2015), Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons, Journal of the American Chemical Society 137(27): 8851-8857.
- Zhang Q., Rijssel E.R. van, Walvoort M.T.C., Overkleeft H.S., Marel G.A. van der & Codée J.D.C. (2015), Acceptor reactivity in the total synthesis of alginate fragments containing α-L-guluronic acid and β-D-mannuronic acid, Angewandte Chemie (International Edition) 54(26): 7670-7673.
- Wisse P., Geus M.A.R. de, Cross G., Nieuwendijk A.M.C.H. van den, Rooden E.J. van, Berg R.J.B.H.N. van den, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2015), Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy, Journal of Organic Chemistry (JOC) 80(14): 7258-65.
- Ouairy C.M.J., Ferraz M.J., Boot R.G., Baggelaar M.P., Stelt M. van der, Appelman M., Marel G.A. van der, Florea B.I., Aerts J.M.F.G. & Overkleeft H.S. (2015), Development of an acid ceramidase activity-based probe, Chemical Communications 51(28): 6161-6163.
- Liu N., Hoogendoorn S., Kar B. van de, Kaptein A., Barf T., Driessen C., Filippov D.V., Marel G.A. van der, Stelt M. van der & Overkleeft H.S. (2015), Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study, Organic and Biomolecular Chemistry 13(18): 5147-5157.
- Padwal J.D., Filippov D.V., Narhe B.D., Aertssen S., Beuving R.J., Benningshof J.C.J., Marel G.A. van der, Overkleeft H.S. & Van der Stelt M. (2015), Cyclopentitol as a scaffold for a natural product-like compound library for drug discovery, Bioorganic & Medicinal Chemistry 23(11): 2650-2655.
- Hoogendoorn S., Mock E.D., Strijland A., Donker-Koopman W.E., Elst H. van den, Berg R.J.B.H.N. van den, Aerts J.M.F.G., Marel G.A. van der & Overkleeft H.S. (2015), Ortho-Carborane-modified N-substituted Deoxynojirimycins, European Journal of Organic Chemistry 2015(20): 4437-4446.
- Mirzaian M., Wisse P., Ferraz M.J., Gold H., Donker-Koopman W.E., Verhoek M., Overkleeft H.S., Boot R.G., Kramer G., Dekker N. & Aerts J.M.F.G. (2015), Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard, Blood Cells, Molecules and Diseases 54(4): 307-314.
- Jiang J., Beenakker T.J.M., Kallemeijn W.W., Marel G.A. van der, Elst H. van der, Codee J.D.C., Aerts J.M.F.G. & Overkleeft H.S. (2015), Comparing Cyclophellitol N-Alkyl and N-Acyl Cyclophellitol Aziridines as Activity-Based Glycosidase Probes, Chemistry: a European Journal 21(30): 10861-10869.
- Wel T. van der, Janssen F.J., Baggelaar M.P., Deng H., Dulk H. den, Overkleeft H.S. & Stelt M. van der (2015), A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase alpha, Journal of Lipid Research 56(4): 927-935.
- Matusiak N., Castelli R., Tuin A.W., Overkleeft H.S., Wisastra R., Dekker F.J., Prely L.M., Bischoff R.P.M., Waarde A. van, Dierckx R.A.J.O. & Elsinga P.H. (2015), A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [F-18]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging, Bioorganic & Medicinal Chemistry 23(1): 192-202.
- Volbeda A.G., Kistemaker H.A.V., Overkleeft H.S., Marel G.A. van der, Filippov D.V. & Codee J.D.C. (2015), Chemoselective cleavage of p-methoxybenzyl and 2-naphthylmethyl ethers using a catalytic amount of HCl in hexafluoro-2-propanol, Journal of Organic Chemistry (JOC) 80(17): 8796-8806.
- Kraus J., Kraus M., Liu N., Besse L., Bader J., Geurink P.P., Bruin G. de, Kisselev A.F., Overkleeft H. & Driessen C. (2015), The novel beta 2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells, Cancer Chemotherapy and Pharmacology 76(2): 383-396.
- Chao D.H.M., Kallemeijn W.W., Marques A.R.A., Orre M., Ottenhoff R., Roomen C. van, Foppen E., Renner M.C., Moeton M., Eijk M. van, Boot R.G., Kamphuis W., Hol E.M., Aten J., Overkleeft H.S., Kalsbeek A. & Aerts J.M.F.G. (2015), Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes, PLoS ONE 10(9): e0138107.
- Huber E.M., Bruin G. de, Heinemeyer W., Panigua Soriano G., Overkleeft H.S. & Groll M. (2015), Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors, Journal of the American Chemical Society 137(24): 7835-7842.
- Hsu M.H., Guo C.L., Liou A.Y., Chang T.Y., Ng M.C., Florea B.I., Overkleeft H.S., Wu Y.L., Liao J.C. & Cheng P.L. (2015), Stage-Dependent Axon Transport of Proteasomes Contributes to Axon Development, Developmental Cell 35(4): 418-431.
- Wong C.S., Hoogendoorn S., Marel G.A. van der, Overkleeft H.S. & Codee J.D.C. (2015), Targeted Delivery of Fluorescent High-Mannose-Type Oligosaccharide Cathepsin Inhibitor Conjugates, ChemPlusChem 80(6): 928-937.
- Marques A.R.A., Aten J., Ottenhoff R., Roomen C.P.A.A. van, Moro D.H., Claessen N., Veloz M.F.V., Zhou K., Lin Z., Mirzaian M., Boot R.G., Zeeuw C.I. de, Overkleeft H.S., Yildiz Y. & Aerts J.M.F.G. (2015), Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice, PLoS ONE 10(8): e0135889.
- Downey S.L., Florea B.I., Overkleeft H.S. & Kisselev A.F. (2015), Use of proteasome inhibitors, Current protocols in immunology 109: 9.10.1-9.
- Elsland D.M. van, Bos E., Overkleeft H.S., Koster A.J. & Kasteren S.I. van (2015), The potential of bioorthogonal chemistry for correlative light and electron microscopy: a call to arms, Journal of Chemical Biology 8(4): 1-5.
- Wiemhoefer A., Stargardt A., Linden W.A. van der, Renner M.C., Kesteren R.E. van, Stap J., Raspe M.A., Tomkinson B., Kessels H.W., Ovaa H., Overkleeft H.S., Florea B. & Reits E.A. (2015), Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2, Molecular and Cellular Proteomics 14(8): 2177-2193.
- Ouchaou K., Maire F., Salo O., Ali H., Hankemeier T., Marel G.A. van der, Filippov D.V., Bovenberg R.A.L., Vreeken R.J., Driessen A.J.M. & Overkleeft H.S. (2015), A Mutasynthesis Approach with a Penicillium chrysogenum Delta roqA Strain Yields New Roquefortine D Analogues, ChemBioChem 16(6): 915-923.
- Kistemaker H.A.V., Lameijer L.N., Meeuwenoord N.J., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2015), Synthesis of Well-Defined Adenosine Diphosphate Ribose Oligomers, Angewandte Chemie (International Edition) 54(16): 4915-4918.
- Latorre A., Rodriguez S., Gonzalez F.V., Florea B.I. & Overkleeft H.S. (2015), Synthetic Studies on the Preparation of Alanyl Epoxysulfones as Cathepsin Cysteine Protease Electrophilic Traps, Journal of Organic Chemistry (JOC) 80(15): 7752-7756.
- Jiang J., Kallemeijn W.W., Wright D.W., Nieuwendijk A.M.C.H. van den, Coco Rohde V., Folch E.C., Elst H. van den, Florea B.I., Scheij S., Donker-Koopman W.E., Verhoek M., Li N., Schürmann M., Mink D., Boot R.G., Codée J.D.C., Marel G.A. van der, Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2015), In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 alpha-L-fucosidases, Chemical Science 6(5): 2782-2789.
- Kraus M., Bader J., Geurink P.P., Weyburne E.S., Mirabella A.C., Silzle T., Shabaneh T.B., Linden W.A. van der, Bruin G. de, Haile S.R., Rooden E. van, Appenzeller C., Li N., Kisselev A.F., Overkleeft H. & Driessen C. (2015), The novel beta 2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells, Haematologica 100(10): 1350-1360.
- Keller I.E., Vosyka O., Takenaka S., Kloss A., Dahlmann B., Willems L.I., Verdoes M., Overkleeft H.S., Marcos E., Adnot S., Hauck S.M., Ruppert C., Guenther A., Herold S., Ohno S., Adler H., Eickelberg O. & Meiners S. (2015), Regulation of Immunoproteasome Function in the Lung, Scientific Reports 5: 10230.
- Kistemaker H.A.V., Meeuwenoord N.J., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2015), On the synthesis of oligonucleotides interconnected through pyrophosphate linkages, European Journal of Organic Chemistry 2015(27): 6084-6091.
- Rijssel E.R. van, Delft P. van, Marle D.V. van, Bijvoets S.M., Lodder G., Overkleeft H.S., Marel G.A. van der, Filippov D.V. & Codee J.D.C. (2015), Stereoselectivity in the Lewis Acid Mediated Reduction of Ketofuranoses, Journal of Organic Chemistry (JOC) 80(9): 4553-4565.
- Matusiak N., Waarde A. van, Rozeveld D., Oosterhout A.J.M. van, Heijink I.H., Castelli R., Overkleeft H.S., Bischoff R., Dierckx R.A.J.O. & Elsinga P.H. (2015), MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [F-18]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation, Molecular Imaging and Biology 17(5): 680-687.
- Lehmann K.C., Gulyaeva A., Zevenhoven-Dobbe J.C., Janssen G.M.C., Ruben M., Overkleeft H.S., Veelen P.A. van, Samborskiy D.V., Kravchenko A.A., Leontovich A.M., Sidorov I.A., Snijder E.J., Posthuma C.C. & Gorbalenya A.E. (2015), Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses, Nucleic Acids Research 43(17): 8416-8434.
- Janssen F.J., Baggelaar M.P., Hummel J.J.A., Overkleeft H.S., Cravatt B.F., Boger D.L. & Stelt M. van der (2015), Comprehensive analysis of structure-activity relationships of alpha-ketoheterocycles as sn-1-diacylglycerol lipase alpha inhibitors, Journal of Medicinal Chemistry 58(24): 9742-9753.
- Kistemaker H.A.V., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2015), Branching of poly(ADP-ribose): Synthesis of the Core Motif, Organic Letters 17(17): 4328-4331.
- Rahimian S., Kleinovink J.W., Fransen M.F., Mezzanotte L., Gold H., Wisse P., Overkleeft H., Amidi M., Jiskoot W., Lowik C.W., Ossendorp F. & Hennink W.E. (2015), Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8+ T cell immune response, Biomaterials 37: 469-477.
- Berg R.J.B.H.N. van der, Rijssel E.R. van, Ferraz M.J., Houben J., Strijland A., Donker-Koopman W.E., Wennekes T., Bonger K.M., Ghisaidoobe A.B.T., Hoogendoorn S., Marel G.A. van der, Codee J.D.C., Overkleeft H.S. & Aerts J.M.F.G. (2015), Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors, ChemMedChem 10(12): 2042-2062.
- Pawlak J.B., Gential G.P.P., Ruckwardt T.J., Bremmers J.S., Meeuwenoord N.J., Ossendorp F.A., Overkleeft H.S., Filippov D.V. & Kasteren S.I. (2015), Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation, Angewandte Chemie (International Edition) 54(19): 5628-5631.
- Wisse P., Gold H., Mirzaian M., Guimaraes Da Lomba Ferraz M.J., Lutteke G., Berg R.J.B.H.N. van den, Elst H. van den, Lugtenburg J., Marel G.A. van der, Aerts J.M.F.G., Codee J.D.C. & Overkleeft H.S. (2015), Synthesis of a panel of carbon-13-labelled (glyco)sphingolipids, European Journal of Organic Chemistry 2015(12): 2661-2677.
- Gubbens J., Zhu H., Girard G.A.O., Song L., Florea B.I., Aston P., Ichinose K., Filippov D.V., Young-Hae C., Overkleeft H.S, Challis G.L. & Wezel G.P. van (2014), Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene clusters for different classes of natural products, Chemistry & Biology 21(6): 707-718.
- Kraus M., Muller-Ide H., Ruckrich T., Bader J., Overkleeft H.S. & Driessen C. (2014), Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations, Leukemia Research 38(3): 383-392.
- Kallemeijn W.W., Witte M.D., Voorn-Brouwer T.M., Walvoort M.T.C., Li K.Y., Codee J.D.C., Marel G.A. van der, Boot R.G., Overkleeft H.S. & Aerts J.M.F.G. (2014), A Sensitive Gel-Based Method Combining Distinct Cyclophellitol-Based Probes for the Identification of Acid/Base Residues in Human Retaining Beta-Glucosidases, Journal of Biological Chemistry 289(51): 35351-35362.
- Kasteren S.I. van, Overkleeft H.S., Ovaa H. & Neefjes J.J.C. (2014), Chemical biology of antigen presentation by MHC molecules, Current Opinion in Immunology 26: 21-31.
- Schipper-Krom Sabine, Juenemann Katrin, Jansen Anne H., Wiemhoefer Anne, Van den Nieuwendijk Rianne, Smith Donna L., Hink Mark A., Bates Gillian P., Overkleeft Hermen, Ovaa Huib & Reits Eric (2014), Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies, FEBS Letters 588(1): 151-159.
- Guimaraes da Lomba Ferraz M.J., Kallemeijn W.W., Mirzaian M., Herrera Moro D., Marques A., Wisse P., Boot R.G., Willems L.I., Overkleeft H.S. & Aerts J.M.F.G. (2014), Gaucher disease and Fabry disease: New markers and insights in pathophysiology for two distinct glycosphingolipidoses, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841(5): 811-825.
- Duivenvoorden B.A., Ghauharali K., Scheij S., Boot R.G., Aerts J.M.F.G., Marel G.A. van der, Overkleeft H.S. & Codee J.D.C. (2014), Design and synthesis of 4 '-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates, Carbohydrate Research 399: 26-37.
- Li K.Y., Jiang J., Witte M.D., Kallemeijn W.W., Donker-Koopman W.E., Boot R.G., Aerts J.M.F.G., Codee J.D.C., Marel G.A. van der & Overkleeft H.S. (2014), Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors, 12(39): 7786-7791.
- Willems L.I., Beenakker T.J.M., Murray B., Scheij S., Kallemeijn W.W., Boot R.G., Verhoek M., Donker-Koopman W.E., Guimaraes da Lomba Ferraz M.J., Rijssel E.R. van, Florea B.I., Codee J.D.C., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2014), Potent and Selective Activity-Based Probes for GH27 Human Retaining alpha-Galactosidases, Journal of the American Chemical Society 136(33): 11622-11625.
- Gaspar P., Kallemeijn W.W., Strijland A., Scheij S., Eijk M. van, Aten J., Overkleeft H.S., Balreira A., Zunke F., Schwake M., Sa Miranda M.C. & Aerts J.M.F.G. (2014), Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis, 55(1): 138-145.
- Janssen F.J., Deng H., Baggelaar M.P., Allara M., Wel T. van der, Dulk J. den, Ligresti A., Esbroeck A.C.M. van, McGuire R., Marzo V. di, Overkleeft H.S. & Stelt M. van der (2014), Discovery of Glycine Sulfonamides as Dual Inhibitors of sn-1-Diacylglycerol Lipase alpha and alpha/beta-Hydrolase Domain 6, Journal of Medicinal Chemistry 57(15): 6610-6622.
- Li K.-Y., Kallemeijn W.W., Jiang J., Walvoort M.T.C., Willems L.I., Beenakker T., Elst H. van den, Marel G.A. van der, Codée J.D.C., Aerts J.M.F.G., Florea B.I., Boot R.G., Witte M.D. & Overkleeft H.S. (2014), Rational Design of Activity-Based Retaining β-Exoglucosidase Probes. In: Waldmann H. & Janning P. (red.), Concepts and Case Studies in Chemical Biology: Wiley. 191-206.
- Zom G.G., Filippov D.V., Marel G.A. van der, Overkleeft H.S., Melief C.J. & Ossendorp F.A. (2014), Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule, OncoImmunology 3(7): e947892.
- Delft P. van, Witte W.E.A. de, Meeuwenoord N.J., Noort G.J. van der Heden van, Versluis F., Olsthoorn R.R.C.L., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2014), Design of a ribosyltriazole-annulated cyclooctyne for oligonucleotide labeling by strain-promoted alkyne-azide cycloaddition, European Journal of Organic Chemistry 2014(34): 7566-7571.
- Thijssen R., Geest C.R., Rooij M.F. de, Liu N., Florea B.I., Weller K., Overkleeft H.S., Oers M.H. van, Spaargaren M., Kater A.P. & Eldering E. (2014), Overcoming resistance to the novel BH3-mimetic ABT-199 in a CLL lymph node model; the role of ABL and BTK, Haematologica 99: 42-42.
- Wieber S., Florea B., Wagner A., Overkleeft H., Hecker M. & Drews O. (2014), Towards cell-specific targeting of proteasomes in cardiovascular cells, Acta Physiologica 210: 194-194.
- Willems Lianne I., Beenakker Thomas J.M., Murray Benjamin, Gagestein Berend, Van den Elst Hans, Van Rijssel Erwin R., Codee Jeroen D.C., Kallemeijn Wouter W., Aerts Johannes M.F.G., Van der Marel Gijsbert A. & Overkleeft Herman S. (2014), Synthesis of alpha- and beta-Galactopyranose-Configured Isomers of Cyclophellitol and Cyclophellitol Aziridine, (27): 6044-6056.
- Willems Lianne I., Jiang Jianbing, Li Kah-Yee, Witte Martin D., Kallemeijn Wouter W., Beenakker Thomas J.N., Schroeder Sybrin P., Aerts Johannes M.F.G., Van der Marel Gijsbert A., Codee Jeroen D.C. & Overkleeft Hermen S. (2014), From Covalent Glycosidase Inhibitors to Activity-Based Glycosidase Probes, Chemistry: a European Journal 20(35): 10864-10872.
- Hoogendoorn S., Puijvelde G.H.M. van, Kuiper J., Marel G.A. van der & Overkleeft H.S. (2014), A Multivalent Ligand for the Mannose-6-Phosphate Receptor for Endolysosomal Targeting of an Activity-Based Probe, Angewandte Chemie (International Edition) 53(41): 10975-10978.
- Ghisaidoobe Amar T., Van den Berg Richard J.B.H.N., Butt Saleem S., Strijland Anneke, Donker-Koopman Wilma E., Scheij Saskia, Van den Nieuwendijk Adrianus M.C.H., Koomen Gerrit-Jan, Van Loevezijn Arnold, Leemhuis Mark, Wennekes Tom, Van der Stelt Mario, Van der Marel Gijsbert A., Van Boeckel Constant A.A., Aerts Johannes M.F.G. & Overkleeft Herman S. (2014), Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors, Journal of Medicinal Chemistry 57(21): 9096-9104.
- Mueller Sebastian, Garcia-Gonzalez Eva, Mainz Andi, Hertlein Gillian, Heid Nina C., Moesker Eva, Van den Elst Hans, Overkleeft Herman S., Genersch Elke & Suessmuth Roderich D. (2014), Paenilamicin: Structure and Biosynthesis of a Hybrid Nonribosomal Peptide/Polyketide Antibiotic from the Bee Pathogen Paenibacillus larvae, 53(40): 10821-10825.
- Soriano Guillem Paniagua, De Bruin Gerjan, Overkleeft Herman S. & Florea Bogdan I. (2014), Toward Understanding Induction of Oxidative Stress and Apoptosis by Proteasome Inhibitors, Antioxidants & Redox Signaling 21(17): 2419-2443.
- Chandrasekar Balakumaran, Colby Thomas, Emon Asif Emran Khan, Jiang Jianbing, Villamor Joji Grace, Harzen Anne, Overkleeft Herman S. & Van der Hoorn Renier A.L. (2014), Broad-range Glycosidase Activity Profiling, Molecular and Cellular Proteomics 13(10): 2787-2800.
- Hansen Mickel J., Velema Willem A., De Bruin Gerjan, Overkleeft Herman S., Szymanski Wiktor & Feringa Ben L. (2014), Proteasome Inhibitors with Photocontrolled Activity, 15(14): 2053-2057.
- Nabuurs Rob J.A., Kapoerchan Varsha V., Metaxas Athanasios, De Jongh Sanne, De Backer Maaike, Welling Mick M., Jiskoot Wim, Windhorst Albert D., Overkleeft Hermen S., Van Buchem Mark A., Overhand Mark & Van der Weerd Louise (2014), Polyfluorinated bis-styrylbenzenes as amyloid-beta plaque binding ligands, 22(8): 2469-2481.
- Willems Marian M.J.H.P., Zom Gijs G., Khan Selina, Meeuwenoord Nico, Melief Cornelis J.M., Van der Stelt Mario, Overkleeft Herman S., Codee Jeroen D.C., Van der Marel Gijsbert A., Ossendorp Ferry & Filippov Dmitri V. (2014), N-Tetradecylcarbamyl Lipopeptides as Novel Agonists for Toll-like Receptor 2, Journal of Medicinal Chemistry 57(15): 6873-6878.
- Willems M.M.J.H.P., Zom G.G., Meeuwenoord N., Ossendorp F.A., Overkleeft H.S., Van der Marel G.A., Codee J.D.C. & Filippov D.V. (2014), Design, automated synthesis and immunological evaluation of NOD2-ligand-antigen conjugates, Beilstein Journal of Organic Chemistry 10: 1445-1453.
- Engelsma Sander B., Willems Lianne I., Van Paaschen Claudia E., Van Kasteren Sander I., Van der Marel Gijsbert A., Overkleeft Herman S. & Filippov Dmitri V. (2014), Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels-Alder Ligation, 16(10): 2744-2747.
- Willems Lianne I., Overkleeft Herman S. & Van Kasteren Sander I. (2014), Current Developments in Activity-Based Protein Profiling, Bioconjugate Chemistry 25(7): 1181-1191.
- Li Hao, Van der Linden Wouter A., Verdoes Martijn, Florea Bogdan I., McAllister Fiona E., Govindaswamy Kavitha, Elias Joshua E., Bhanot Purnima, Overkleeft Herman S. & Bogyo Matthew (2014), Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes, ACS Chemical Biology 9(8): 1869-1876.
- Wilkins Owen M., Downey Sondra L., Weyburne Emily S., Williams David A., Mirabella Anne C., Overkleeft Herman S. & Kisselev Alexei F. (2014), Cell-line-specific high background in the Proteasome-Glo assay of proteasome trypsin-like activity, Analytical Biochemistry 451: 1-3.
- Castelli Riccardo, Schindler Severin, Walter Sebastian M., Kniep Florian, Overkleeft Herman S., Van der Marel Gijsbert A., Huber Stefan M. & Codee Jeroen D.C. (2014), Activation of Glycosyl Halides by Halogen Bonding, Chemistry - An Asian Journal 9(8): 2095-2098.
- Xin Bo-Tao, De Bruin Gerjan, Verdoes Martijn, Filippov Dmitri V., Van der Marel Gijs A. & Overkleeft Herman S. (2014), Exploring dual electrophiles in peptide-based proteasome inhibitors: carbonyls and epoxides, 12(30): 5710-5718.
- Li Kah-Yee, Jiang Jianbing, Witte Martin D., Kallemeijn Wouter W., Van den Elst Hans, Wong Chung-Sing, Chander Sharina D., Hoogendoorn Sascha, Beenakker Thomas J.M., Codee Jeroen D.C., Aerts Johannes M.F.G., Van der Marel Gijs A. & Overkleeft Herman S. (2014), Synthesis of Cyclophellitol, Cyclophellitol Aziridine, and Their Tagged Derivatives, (27): 6030-6043.
- De Bruin Gerjan, Huber Eva M., Xin Bo-Tao, Van Rooden Eva J., Al-Ayed Karol, Kim Kyung-Bo, Kisselev Alexei F., Driessen Christoph, Van der Stelt Mario, Van der Marel Gijsbert A., Groll Michael & Overkleeft Herman S. (2014), Structure-Based Design of beta 1i or beta 5i Specific Inhibitors of Human Immunoproteasomes, Journal of Medicinal Chemistry 57(14): 6197-6209.
- Zom Gijs G., Khan Selina, Britten Cedrik M., Sommandas Vinod, Camps Marcel G. M., Loof Nikki M., Budden Christina F., Meeuwenoord Nico J., Filippov Dmitri V., Van der Marel Gijsbert A., Overkleeft Hermen S., Melief Cornelis J.M. & Ossendorp Ferry (2014), Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand-Peptide Conjugates, Cancer Immunology Research 2(8): 756-764.
- Van Rijssel Erwin R., Van Delft Pieter, Lodder Gerrit, Overkleeft Herman S., Van der Marel Gijsbert A., Filippov Dmitri V. & Codee Jeroen D.C. (2014), Furanosyl Oxocarbenium Ion Stability and Stereoselectivity, 53(39): 10381-10385.
- Kasteren S.I. van & Overkleeft H.S. (2014), Endo-lysosomal proteases in antigen presentation , Current Opinion in Chemical Biology 23(0): 8 - 15.
- Ongay Sara, Hermans Jos, Bruins Andries P., Nieuwendijk Adrianus M.C.H., Overkleeft Hermen & Bischoff Rainer (2013), Electron Transfer and Collision Induced Dissociation of Non-Derivatized and Derivatized Desmosine and Isodesmosine, Journal of The American Society for Mass Spectrometry 24(1): 83-91.
- Piwowarska Natalia A., Banala Srinivas, Overkleeft Hermen S. & Suessmuth Roderich D. (2013), Arg-Thz is a minimal substrate for the N-alpha,N-alpha-arginyl methyltransferase involved in the biosynthesis of plantazolicin, Chemical Communications 49(91): 10703-10705.
- Kistemaker Hans A.V., Noort Gerbrand J. van der Heden, Overkleeft Herman S., Van der Marel Gijsbert A. & Filippov Dmitri V. (2013), Stereoselective Ribosylation of Amino Acids, 15(9): 2306-2309.
- Castelli Riccardo, Overkleeft Herman S., Van der Marel Gijsbert A. & Codee Jeroen D.C. (2013), 2,2-Dimethyl-4-(4-methoxy-phenoxy) butanoate and 2,2-Dimethyl-4-azido Butanoate: Two New Pivaloate-ester-like Protecting Groups, 15(9): 2270-2273.
- Van Rijssel Erwin R., Goumans Theodorus P.M., Lodder Gerrit, Overkleeft Herman S., Van der Marel Gijsbert A. & Codee Jeroen D.C. (2013), Chiral Pyrroline-Based Ugi-Three-Component Reactions Are under Kinetic Control, 15(12): 3026-3029.
- Van Noort Gerbrand, Heden J. van der, Schein Catherine H., Overkleeft Herman S., Van der Marel Gijsbert A. & Filippov Dmitri V. (2013), A general synthetic method toward uridylylated picornavirus VPg proteins, 19(6): 333-336.
- De Jong Ana R., Volbeda Anne G., Hagen Bas, Van den Elst Hans, Overkleeft Herman S., Van der Marel Gijsbert A. & Codee Jeroen D.C. (2013), A Second-Generation Tandem Ring-Closing Metathesis Cleavable Linker for Solid-Phase Oligosaccharide Synthesis, European Journal of Organic Chemistry 2013(29): 6644-6655.
- Otero Jose M., van der Knaap Matthijs, Llamas-Saiz Antonio L., Van Raaij Mark J., Amorin Manuel, Granja Juan R., Filippov Dmitri V., Van der Marel Gijsbert A., Overkleeft Herman S. & Overhand Mark (2013), Design, Synthesis, and Structural Analysis of Turn Modified cyclo-(alpha beta(3)alpha beta(2)alpha)(2) Peptide Derivatives toward Crystalline Hexagon-Shaped Cationic Nanochannel Assemblies, Crystal Growth & Design 13(10): 4355-4367.
- Walvoort Marthe T.C., Van der Marel Gijsbert A., Overkleeft Herman S. & Codee Jeroen D.C. (2013), On the reactivity and selectivity of donor glycosides in glycochemistry and glycobiology: trapped covalent intermediates, Chemical Science 4(3): 897-906.
- Geurink Paul P., Van der Linden Wouter A., Mirabella Anne C., Gallastegui Nerea, De Bruin Gerjan, Blom Annet E.M., Voges Mathias J., Mock Elliot D., Florea Bogdan I., Van der Marel Gijs A., Driessen Christoph, Van der Stelt Mario, Groll Michael, Overkleeft Herman S. & Kisselev Alexei F. (2013), Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites, Journal of Medicinal Chemistry 56(3): 1262-1275.
- Baggelaar M.P., Janssen F.J., Esbroeck A.C.M. van, Dulk J. den, Allara M., Hoogendoorn S., McGuire R., Florea B.I., Meeuwenoord N.J., Elst H. van den, Marel G.A. van der, Brouwer J., Marzo V. di, Overkleeft H.S. & Stelt M. van der (2013), Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-alpha in Brain, Angewandte Chemie (International Edition) 52(46): 12081-12085.
- Gold H., Mirzaian M., Dekker N., Joao Ferraz M., Lugtenburg J., Codee J.D.C., Marel G.A. van der, Overkleeft H.S., Linthorst G.E., Groener J.E.M., Aerts J.M.F.G. & Poorthuis B.J.H.M. (2013), Quantification of Globotriaosylsphingosine in Plasma and Urine of Fabry Patients by Stable Isotope Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry, Clinical Chemistry 59(3): 547-556.
- Krawczyk Bartlomiej, Van Herwerden Eric F., Overkleeft Herman S. & Suessmuth Roderich D. (2013), Elimination Reactions of Esters in the Biosynthesis of Polyketides and Ribosomal Peptides, Angewandte Chemie - International Edition in English 52(35): 9082-9084.
- Ferraz M.J., Kallemeijn W.W., Mirzaian M., Herrera Moro D., Marques A., Wisse P., Boot R.G., Willems L.I., Overkleeft H.S. & Aerts J.M. (2013), Gaucher disease and Fabry disease: New markers and insights in pathophysiology for two distinct glycosphingolipidoses, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841(5): 811-815.
- Li N., Kuo C.L., Paniagua G., Elst H. van der, Verdoes M., Willems L.I., Linden W.A. van der, Ruben M., Genderen E. van, Gubbens J., Wezel G.P. van, Overkleeft H.S. & Florea B.I. (2013), Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS, Nature Physics 8(6): 1155-1168.
- Gillis J., Schipper-Krom S., Juenemann K., Gruber A., Coolen S., Nieuwendijk A.M.C.H. van den, Veen H. van, Overkleeft H.S., Goedhart J., Kampinga H.H. & Reits E.A. (2013), The DNAJB6 and DNAJB8 Protein Chaperones Prevent Intracellular Aggregation of Polyglutamine Peptides, Journal of Biological Chemistry 288(24): 17225-17237.
- Gubbens J., Janus M., Florea B.I., Overkleeft H.S. & Wezel G.P. van (2012), Identification of glucose kinase dependent and independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics, Molecular Microbiology 86(6): 1490-1507.
- Knijnenburg A.D., Spalburg E., De Neeling A.J., Mars-Groenendijk R.H., Noort D., Grotenbreg G.M., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2012), Ring-Extended Gramicidin S Analogs Containing cis d-Sugar Amino Acid Turn Mimetics with Varying Ring Size, Helvetica Chimica Acta 95(12): .
- Vrins C.L.J., Bietrix F., Lombardo E., Van Roomen C.P.P.A., Ottenhoff R., Overkleeft H.S. & Aerts J.M. (2012), Glycosphingolipid synthesis inhibitor AMP-DNM lowers plasma cholesterol levels by promoting fecal cholesterol excretion without inhibiting cholesterol absorption, Clinical Lipidology 7(2): .
- Gold H., Mirzaian M., Dekker N., Joao Ferraz M., Lugtenburg J., Codée J.D., Van der Marel G.A., Overkleeft H.S., Linthorst G.E., Groener J.E.M., Aerts J.M. & Poorthuis B.J.H.M. (2012), Quantification of globotriaosylsphingosine in plasma and urine of Fabry patients by stable isotope ultraperformance liquid chromatography-tandem mass spectrometry, Clinical Chemistry 59(3): 547–556.
- Li N., Overkleeft H.S. & Florea B.I. (2012), Activity-based protein profiling: an enabling technology in chemical biology research, Current Opinion in Chemical Biology 16(1-2): .
- Kapoerchan V.V., Knijnenburg A.D., Keizer P., Spalburg E., De Neeling A.J., Mars-Groenendijk R.H., Noort D., Otero J.M., Llamas-Saiz A.L., Van Raaij M.J., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2012), 'Inverted' analogs of the antibiotic gramicidin S with an improved biological profile, Bioorganic & Medicinal Chemistry 20(20): .
- De Jong A.R., Hagen B., Van der Ark V., Overkleeft H.S., Codee J.D.C. & Van der Marel G.A. (2012), Exploring and Exploiting the Reactivity of Glucuronic Acid Donors, Journal of Organic Chemistry (JOC) 77(1): .
- Nieuwendijk A.M.C.H. van den, Berg R.J.B.H.N. van den, Ruben M., Witte M.D., Brussee J., Boot R.G., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2012), Synthesis of Eight 1-Deoxynojirimycin Isomers from a Single Chiral Cyanohydrin, European Journal of Organic Chemistry 2012(18): 3437-3446.
- Hogendorf W.F.J., Lameijer L.N., Beenakker T.J.M., Overkleeft H.S., Filippov D.V., Codee J.D.C. & Van der Marel G.A. (2012), Fluorous Linker Facilitated Synthesis of Teichoic Acid Fragments, 14(3): .
- Lombardo E., Roomen C.P.A.A. van, Van Puijvelde G.H., Ottenhoff R., Eijk M. van, Aten J., Kuiper J., Overkleeft H.S., Groen A.K., Verhoeven A.J., Aerts J.M.F.G. & Bietrix F. (2012), Correction of Liver Steatosis by a Hydrophobic Iminosugar Modulating Glycosphingolipids Metabolism, PLoS ONE 7(10): 38520.
- Wennekes T., Bonger K.M., Vogel K., Van den Berg R.J.B.H.N., Strijland A., Donker-Koopman W.E., Aerts J.M.F.G., Van der Marel G.A. & Overkleeft H.S. (2012), The Development of an Aza-C-Glycoside Library Based on a Tandem Staudinger/Aza-Wittig/Ugi Three-Component Reaction, European Journal of Organic Chemistry (32): .
- Van der Heden Van Noort G.J., Van Delft P., Meeuwenoord N.J., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2012), Fully automated sequential solid phase approach towards viral RNA-nucleopeptides, Chemical Communications 48(65): 8093-8095.
- Kallemeijn W.W., Li K.Y., Witte M.D., Marques A.R.A., Aten J., Scheij S., Jiang J., Willems L.I., Voorn-Brouwer T.M., Roomen C.P.A.A. van, Ottenhoff R., Boot R.G., Elst H. van den, Walvoort M.T.C., Florea B.I., Codee J.D.C., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2012), Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie (International Edition) 51(50): 12529-12533.
- Van der Knaap M., Basalan F., Van de Mei H.C., Busscher H.J., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2012), Synthesis and Biological Evaluation of Gramicidin S-Inspired Cyclic Mixed a/ss-Peptides, Chemistry and Biodiversity 9(11): .
- Kisselev A.F., Van der Linden W.A. & Overkleeft H.S. (2012), Proteasome Inhibitors: An Expanding Army Attacking a Unique Target, Chemistry & Biology 19(1): .
- Walvoort M.T.C., Van den Elst H., Plante O.J., Krock L., Seeberger P.H., Overkleeft H.S., Van der Marel G.A. & Codee J.D.C. (2012), Automated Solid-Phase Synthesis of beta-Mannuronic Acid Alginates, Angewandte Chemie - International Edition in English 51(18): .
- Driessen C., Kraus M., Van der Linden W.A., Bader J. & Overkleeft H.S. (2012), PR671, the first proteasome inhibitor that selectively inhibits the bortezomib/carfilzomib insensitive beta 2 proteasome subunits, overcomes bortezomib/carfilzomib resistance in myeloma cells in vitro, Onkologie 35: .
- Van der Linden W.A., Li N., Hoogendoorn S., Ruben M., Verdoes M., Guo J., Boons G.J., Van der Marel G.A., Florea B.I. & Overkleeft H.S. (2012), Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: A comparative study, Bioorganic & Medicinal Chemistry 20(2): .
- Christina A.E., Muns J.A., Olivier J.Q.A., Visser L., Hagen B., Van den Bos L.J., Overkleeft H.S., Codee J.D.C. & Van der Marel G.A. (2012), On the Reactivity and Selectivity of Galacturonic Acid Lactones, European Journal of Organic Chemistry (29): .
- Christina A.E., Ferrando V.M.B., De Bordes F., Spruit W.A., Overkleeft H.S., Codee J.D.C. & Van der Marel G.A. (2012), Multigram-scale synthesis of an orthogonally protected 2-acetamido-4-amino-2,4,6-trideoxy-D-galactose (AAT) building block, Carbohydrate Research 356: .
- Van der Linden W.A., Willems L.I., Shabaneh T.B., Li N., Ruben M., Florea B.I., Van der Marel G.A., Kaiser M., Kisselev A.F. & Overkleeft H.S. (2012), Discovery of a potent and highly beta 1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones, ORGANIC & BIOMOLECULAR CHEMISTRY 10(1): .
- Van der Knaap M., Otero J.M., Llamas-Saiz A.L., Van Raaij M.J., Lageveen L.I., Busscher H.J., Grotenbreg G.M., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2012), Design, synthesis and structural analysis of mixed alpha/beta-peptides that adopt stable cyclic hairpin-like conformations, Tetrahedron 68(10): .
- Richau K.H., Kaschani F., Verdoes M., Pansuriya T.C., Niessen S., Stuber K., Colby T., Overkleeft H.S., Bogyo M. & Van der Hoorn R.A.L. (2012), Subclassification and Biochemical Analysis of Plant Papain-Like Cysteine Proteases Displays Subfamily-Specific Characteristics, 158(4): .
- Hogendorf W.F.J., Kropec A., Filippov D.V., Overkleeft H.S., Huebner J., Van der Marel G.A. & Codee J.D.C. (2012), Light fluorous synthesis of glucosylated glycerol teichoic acids, Carbohydrate Research 356: .
- Li J., Girard G., Florea B.I., Geurink P.P., Li N., Marel G.A. van der, Overhand M., Overkleeft H.S. & Wezel G.P. van (2012), Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach, Organic and Biomolecular Chemistry 10(43): 8677-8683.
- Barroso S., Castelli R., Baggelaar M.P., Geerdink D., Ter Horst B., Casas-Arce E., Overkleeft H.S., Van der Marel G.A., Codee J.D.C. & Minnaard A.J. (2012), Total Synthesis of the Triglycosyl Phenolic Glycolipid PGL-tb1 from Mycobacterium tuberculosis, Angewandte Chemie - International Edition in English 51(47): .
- Janssen K.G.H., Li J.J., Hoang H.T., Vulto P., Van den Berg R.J.B.H.N., Overkleeft H.S., Eijkel J.C.T., Tas N.R., Van der Linden H.J. & Hankemeier T. (2012), Limits of miniaturization: Assessing ITP performance in sub-micron and nanochannels, LAB ON A CHIP 12(16): .
- Walvoort M.T.C., Kallemeijn W.W., Willems L.I., Witte M.D., Aerts J.M.F.G., Van der Marel G.A., Codee J.D.C. & Overkleeft H.S. (2012), Tuning the leaving group in 2-deoxy-2-fluoroglucoside results in improved activity-based retaining beta-glucosidase probes, Chemical Communications 48(84): .
- Christina A.E., Van der Es D., Dinkelaar J., Overkleeft H.S., Van der Marel G.A. & Codee J.D.C. (2012), beta-Rhamnosides from 6-thio mannosides, Chemical Communications 48(21): .
- Willems L.I., Li N., Florea B.I., Ruben M., Van der Marel G.A. & Overkleeft H.S. (2012), Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities, Angewandte Chemie - International Edition in English 51(18): .
- Walvoort M.T.C., Volbeda A.G., Reintjens N.R.M., Van den Elst H., Plante O.J., Overkleeft H.S., Van der Marel G.A. & Codee J.D.C. (2012), Automated Solid-Phase Synthesis of Hyaluronan Oligosaccharides, 14(14): .
- Chang J.T., Ciocca M.L., Kinjyo I., Palanivel V.R., McClurkin C.E., De Jong C.S., Mooney E.C., Kim J.S., Steinel N.C., Oliaro J., Yin C.C., Florea B.I., Overkleeft H.S., Berg L.J., Russell S.M., Koretzky G.A., Jordan M.S. & Reiner S.L. (2011), Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division, Immunity 34(4): .
- Kraus M., Bader J., Hess D., Haile S., Overkleeft H., Driessen C. & Sakk . (2011), The HIV protease inhibitor Nelfinavir has proteasome-inhibiting activity in vivo distinct from Bortezomib, Onkologie 34: .
- Clerc J., Li N., Krahn D., Groll M., Bachmann A.S., Florea B.I., Overkleeft H.S. & Kaiser M. (2011), The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity, Chemical Communications 47(1): .
- Walvoort M.T.C., De Witte W., Van Dijk J., Dinkelaar J., Lodder G., Overkleeft H.S., Codee J.D.C. & Van der Marel G.A. (2011), Mannopyranosyl Uronic Acid Donor Reactivity, Organic Letters 13(16): 4360-4363.
- Van Delft P., Van Schie E., Meeuwenoord N.J., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2011), Oligonucleotide Conjugates by Means of Copper-Free Click Chemistry - Expanding the Repertoire of Strained Cyclooctyne Phosphoramidites, Synthesis Stuttgart (17): .
- Codee J.D.C., Christina A.E., Walvoort M.T.C., Overkleeft H.S. & Van der Marel G.A. (2011), Uronic Acids in Oligosaccharide and Glycoconjugate Synthesis, Topics in Current Chemistry 301: .
- Hoogendoorn S., Blom A.E.M., Willems L.I., Van der Marel G.A. & Overkleeft H.S. (2011), Synthesis of pH-Activatable Red Fluorescent BODIPY Dyes with Distinct Functionalities, 13(20): .
- Knijnenburg A.D., Kapoerchan V.V., Grotenbreg G.M., Spalburg E., De Neeling A.J., Mars-Groenendijk R.H., Noort D., Otero J.M., Llamas-Saiz A.L., Van Raaij M.J., Ravensbergen B., Nibbering P.H., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2011), Synthesis and evaluation of strand and turn modified ring-extended gramicidin S derivatives, 19(11): .
- Witte M.D., Walvoort M.T.C., Li K.Y., Kallemeijn W.W., Donker-Koopman W.E., Boot R.G., Aerts J.M.F.G., Codee J.D.C., Marel G.A. van der & Overkleeft H.S. (2011), Activity-Based Profiling of Retaining beta-Glucosidases: A Comparative Study, ChemBioChem 12(8): 1263-1269.
- Ghisaidoobe A., Bikker P., Bruijn A.C.J. de, Godschalk F.D., Rogaar E., Guijt M.C., Hagens P., Halma J.M., Hart S.M. van 't, Luitjens S.B., Rixel V.H.S. van, Wijzenbroek M., Zweegers T., Donker-Koopman W.E., Strijland A., Boot R.G., Marel G.A. van der, Overkleeft H.S., Aerts J.M.F.G. & Berg R.J.B.H.N. van den (2011), Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars, ACS Medicinal Chemistry Letters 2(2): 119-123.
- Dekker N., Dussen L. van, Hollak C.E.M., Overkleeft H., Scheij S., Ghauharali K., Breemen M.J. van, Ferraz M.J., Groener J.E.M., Maas M., Wijburg F.A., Speijer D., Tylki-Szymanska A., Mistry P.K., Boot R.G. & Aerts J.M.F.G. (2011), Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response, Blood 118(16): e118-27.
- Dekker N., Voorn-Brouwer T., Verhoek M., Wennekes T., Narayan R.S., Speijer D., Hollak C.E.M., Overkleeft H.S., Boot R.G. & Aerts J.M.F.G. (2011), The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation, Blood Cells, Molecules and Diseases 46(1): 19-26.
- Gold H., Munneke S., Dinkelaar J., Overkleeft H.S., Aerts J.M.F.G., Codee J.D.C. & Van der Marel G.A. (2011), A practical synthesis of capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates, Carbohydrate Research 346(12): .
- Aerts J.M.F.G., Boot R.G., Eijk M.C. van, Groener J., Bijl N., Lombardo E., Bietrix F.M., Dekker N., Groen A.K., Ottenhoff R., Roomen C. van, Aten J., Serlie M., Langeveld M., Wennekes T. & Overkleeft H.S. (2011), Glycosphingolipids and insulin resistance. In: Cowart L.A. (red.), Sphingolipids and Metabolic Disease. Advances in Experimental Medicine and Biology nr. 721. New York, NY, U.S.A.: Springer. 20-41.
- Smid B.E., Rombach S.M., Aerts J.M.F.G., Kuiper S., Mirzaian M., Overkleeft H.S., Poorthuis B.J.H.M., Hollak C.E.M., Groener J.E.M. & Linthorst G.E. (2011), Consequences of a global enzyme shortage of agalsidase beta in adult Dutch Fabry patients, Orphanet Journal of Rare Diseases 6: .
- Berg R.J.B.H.N. van den., Elst H. van den., Korevaar C.G.N., Aerts J.M.F.G., Marel G.A. van der. & Overkleeft H.S. (2011), A Rapid and Efficient Synthesis of D-erythro-Sphingosine from D-ribo-Phytosphingosine, European Journal of Organic Chemistry 2011(33): 6685-6689.
- Berg R.J.B.H.N. van den, Wennekes T., Ghisaidoobe A., Donker-Koopman W.E., Strijland A., Boot R.G., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2011), Assessment of Partially Deoxygenated Deoxynojirimycin Derivatives as Glucosylceramide Synthase Inhibitors, ACS Medicinal Chemistry Letters 2(7): 519-522.
- Aerts J.M.F.G., Kallemeijn W.W., Wegdam W., Joao Ferraz M., Van Breemen M.J., Dekker N., Kramer G., Poorthuis B.J., Groener J.E.M., Cox-Brinkman J., Rombach S.M., Hollak C.E.M., Linthorst G.E., Witte M.D., Gold H., Marel G.A. van der, Overkleeft H.S. & Boot R.G. (2011), Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies, Journal of Inherited Metabolic Disease 34(3): 605-619.
- Gold H., Boot R.G., Aerts J.M.F.G., Overkleeft H.S., Codee J.D.C. & Marel G.A. van der (2011), A Concise Synthesis of Globotriaosylsphingosine, European Journal of Organic Chemistry (9): 1652-1663.
- Aerts J.M.F.G., Boot R.G., Eijk M.C. van, Groener J., Bijl N., Lombardo E., Bietrix F.M., Dekker N., Groen A.K., Ottenhoff R., Roomen C. van, Aten J., Serlie M., Langeveld M., Wennekes T. & Overkleeft H.S. (2011), Glycosphingolipids and insulin resistance, Advances in Experimental Medicine and Biology 721: 99-119.
- Hoogendoorn S., Habets K.L., Passemard S., Kuiper J., Marel G.A. van der, Florea B.I. & Overkleeft H.S. (2011), Targeted pH-dependent fluorescent activity-based cathepsin probes, Chemical Communications 47(33): .
- Codeé J.D.C., Christina A.E., Walvoort M.T.C., Overkleeft H.S. & Marel G.A. van der (2011), Uronic Acids in Oligosaccharide and Glycoconjugate Synthesis. In: Fraser-Reid B. & Cristóbal-López J. (red.), Reactivity Tuning in Oligosaccharide Assembly nr. 301: Springer-Verlag Berlin Heidelberg. 253-289.
- Geurink P.P., Florea B.I. & Overkleeft H.S. (2011), Activity-Based Profiling of 2-Oxoglutarate Oxygenases, Chemistry & Biology 18(5): .
- Dekker N., Voorn-Brouwer T., Verhoek M., Wennekes T., Narayan R.S., Speijer D., Hollak C.E.M., Overkleeft H.S., Boot R.G. & Aerts J.M.F.G. (2011), The cytosolic beta-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation, Blood Cells, Molecules and Diseases 46(1): .
- Geurink P.P., Prely L.M., Van der Marel G.A., Bischoff R. & Overkleeft H.S. (2011), Photoaffinity Labeling in Activity-Based Protein Profiling, Topics in Current Chemistry : .
- Walvoort M.T.C., Moggre G.J., Lodder G., Overkleeft H.S., Codee J.D.C. & Van der Marel G.A. (2011), Stereoselective Synthesis of 2,3-Diamino-2,3-dideoxy-beta-D-mannopyranosyl Uronates, Journal of Organic Chemistry (JOC) 76(18): .
- Hogendorf W.F.J., Meeuwenoord N.J., Overkleeft H.S., Filippov D.V., Laverde D., Kropec A., Huebner J., Van der Marel G.A. & Codee J.D.C. (2011), Automated solid phase synthesis of teichoic acids, Chemical Communications 47(31): .
- Kolodziejek I., Misas-Villamil J.C., Kaschani F., Clerc J., Gu C., Krahn D., Niessen S., Verdoes M., Willems L.I., Overkleeft H.S., Kaiser M. & Van der Hoorn R.A.L. (2011), Proteasome Activity Imaging and Profiling Characterizes Bacterial Effector Syringolin A, 155(1): .
- Witte M.D., Van der Marel G.A., Aerts J.M.F.G. & Overkleeft H.S. (2011), Irreversible inhibitors and activity-based probes as research tools in chemical glycobiology, 9(17): .
- Codee J.D.C., Ali A., Overkleeft H.S. & Van der Marel G.A. (2011), Novel protecting groups in carbohydrate chemistry, Comptes Rendus Chimie 14(2-3): 178-193.
- Bonger K.M., Hoogendoorn S., Van Koppen C.J., Timmers C.M., Van der Marel G.A. & Overkleeft H.S. (2011), Development of Selective LH Receptor Agonists by Heterodimerization with a FSH Receptor Antagonist, ACS Medicinal Chemistry Letters 2(1): .
- Kessler J.H., Khan S., Seifert U., Le Gall S., Chow K.M., Paschen A., Bres-Vloemans S.A., De Ru A., Van Montfoort N., Franken K.L.M.C., Benckhuijsen W.E., Brooks J.M., Van Hall T., Ray K., Mulder A., Doxiadis I.I.N., Van Swieten P.F., Overkleeft H.S., Prat A., Tomkinson B., Neefjes J., Kloetzel P.M., Rodgers D.W., Hersh L.B., Drijfhout J.W., Van Veelen P.A., Ossendorp F. & Melief C.J.M. (2011), Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes, Nature Immunology 12(1): 45-53.
- Christina A.E., Van den Bos L.J., Overkleeft H.S., Van der Marel G.A. & Codee J.D.C. (2011), Galacturonic Acid Lactones in the Synthesis of All Trisaccharide Repeating Units of the Zwitterionic Polysaccharide Sp1, Journal of Organic Chemistry (JOC) 76(6): .
- Knijnenburg A.D., Tuin A.W., Spalburg E., De Neeling A.J., Mars-Groenendijk R.H., Noort D., Otero J.M., Llamas-Saiz A.L., Van Raaij M.J., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2011), Exploring the Conformational and Biological Versatility of beta-Turn-Modified Gramicidin S by Using Sugar Amino Acid Homologues that Vary in Ring Size, Chemistry: a European Journal 17(14): .
- Van Noort G.J.V., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2011), Ribosylation of Adenosine: An Orthogonally Protected Building Block for the Synthesis of ADP-Ribosyl Oligomers, 13(11): .
- Mirabella A.C., Pletnev A.A., Downey S.L., Florea B.I., Shabaneh T.B., Britton M., Verdoes M., Filippov D.V., Overkleeft H.S. & Kisselev A.F. (2011), Specific Cell-Permeable Inhibitor of Proteasome Trypsin-like Sites Selectively Sensitizes Myeloma Cells to Bortezomib and Carfilzomib, Chemistry & Biology 18(5): .
- Willems L.I., Van der Linden W.A., Li N., Li K.Y., Liu N., Hoogendoorn S., Van der Marel G.A., Florea B.I. & Overkleeft H.S. (2011), Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling, Accounts of Chemical Research 44(9): .
- Van der Knaap M., Lageveen L.T., Busscher H.J., Mars-Groenendijk R.H., Noort D., Otero J.M., Llamas-Saiz A.L., Van Raaij M.J., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2011), Evaluation of Readily Accessible Azoles as Mimics of the Aromatic Ring of D-Phenylalanine in the Turn Region of Gramicidin S, ChemMedChem 6(5): .
- Geurink P.P., Klein T., Prely L., Paal K., Leeuwenburgh M.A., Van der Marel G.A., Kauffman H.F., Overkleeft H.S. & Bischoff R. (2010), Design of Peptide Hydroxamate-Based Photoreactive Activity-Based Probes of Zinc-Dependent Metalloproteases, European Journal of Organic Chemistry (11): .
- Walvoort M.T.C., Lodder G., Overkleeft H.S., Codee J.D.C. & Van der Marel G.A. (2010), Mannosazide Methyl Uronate Donors. Glycosylating Properties and Use in the Construction of beta-ManNAcA-Containing Oligosaccharides, Journal of Organic Chemistry (JOC) 75(23): .
- Altun M., Besche H.C., Overkleeft H.S., Piccirillo R., Edelmann M.J., Kessler B.M., Goldberg A.L. & Ulfhake B. (2010), Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway, Journal of Biological Chemistry 285(51): 39597-39608.
- Verdoes M., Willems L.I., Van der Linden W.A., Duivenvoorden B.A., Van der Marel G.A., Florea B.I., Kisselev A.F. & Overkleeft H.S. (2010), A panel of subunit-selective activity-based proteasome probes, Organic and Biomolecular Chemistry 8(12): .
- Knijnenburg A.D., Kapoerchan V.V., Spalburg E., De Neeling A.J., Mars-Groenendijk R.H., Noort D., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2010), Tuning hydrophobicity of highly cationic tetradecameric Gramicidin S analogues using adamantane amino acids, Bioorganic & Medicinal Chemistry : .
- Dekker N., Voorn-Brouwer T., Verhoek M., Wennekes T., Narayan R.S., Speijer D., Hollak C.E., Overkleeft H.S., Boot R.G. & Aerts J.M. (2010), The cytosolic beta-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation, Blood Cells, Molecules and Diseases : .
- Kapoerchan V.V., Spalburg E., De Neeling A.J., Mars-Groenendijk R.H., Noort D., Otero J.M., Ferraces-Casais P., Llamas-Saiz A.L., Van Raaij M.J., Van Doorn J., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2010), Gramicidin S derivatives containing cis- and trans-morpholine amino acids (MAAs) as turn mimetics, Chemistry: a European Journal 16(14): .
- Clerc J., Li N., Krahn D., Groll M., Bachmann A.S., Florea B.I., Overkleeft H.S. & Kaiser M. (2010), The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with substrate selectivity, Chemical Communications : .
- Van Scherpenzeel M., Van den Berg R.J., Donker-Koopman W.E., Liskamp R.M., Aerts J.M., Overkleeft H.S. & Pieters R.J. (2010), Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase, Bioorganic & Medicinal Chemistry 18(1): .
- Wennekes T., Meijer A.J., Groen A.K., Boot R.G., Groener J.E., Eijk M.C. van, Ottenhoff R., Bijl N., Ghauharali K., Song H., O'Shea T.J., Liu H., Yew N., Copeland D., Berg R.J.B.H.N. van den, Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2010), Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation, Journal of Medicinal Chemistry 53(2): 689-698.
- Witte M.D., Kallemeijn W.W., Aten J., Li K.Y., Strijland A., Donker-Koopman W.E., Nieuwendijk A.M.C.H. van den, Bleijlevens B., Kramer G., Florea B.I., Hooibrink B., Hollak C.E.M., Ottenhoff R., Boot R.G., Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2010), Ultrasensitive in situ visualization of active glucocerebrosidase molecules, Nature Chemical Biology 6(12): 907-913.
- Wennekes T., Van den Berg R.J.B.H.N., Boltje T.J., Donker-Koopman W.E., Kuijper B., Van der Marel G.A., Strijland A., Verhagen C.P., Aerts J.M.F.G. & Overkleeft H.S. (2010), Synthesis and Evaluation of Lipophilic Aza-C-glycosides as Inhibitors of Glucosylceramide Metabolism, European Journal of Organic Chemistry (7): 1258-1283.
- Geurink P.P., Liu N., Spaans M.P., Downey S.L., Nieuwendijk A.M.C.H. van der, Marel G.A. van der, Kisselev A.F., Florea B.I. & Overkleeft H.S. (2010), Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome's Chymotrypsin-like Sites, Journal of Medicinal Chemistry 53(5): 2319-2323.
- Dinkelaar J., Duivenvoorden B.A., Wennekes T., Overkleeft H.S., Boot R.G., Aerts J.M.F.G., Codee J.D.C. & Van der Marel G.A. (2010), A Preparative Synthesis of Human Chitinase Fluorogenic Substrate (4'-Deoxychitobiosyl)-4-methylumbelliferone, European Journal of Organic Chemistry (13): 2565-2570.
- Nieuwendijk A.M.C.H. van, Ruben M., Engelsma S.E., Risseeuw M.D.P., Berg R.J.B.H.N. van den, Boot R.G., Aerts J.M.F.G., Brussee J., Marel G.A. van der & Overkleeft H.S. (2010), Synthesis of L-altro-1-Deoxynoprimycin, D-allo-1-Deoxynoprimycin, and D-galacto-1-Deoxynojirimycin from a Single Chiral Cyanohydrin, 12(17): 3957-3959.
- Overkleeft H.S. & Aerts J.M.F.G. (2010), Chemical biology of glucosylceramide metabolism in man, NPC Highlights 2(12): 22-25.
- Van Delft P., Meeuwenoord N.J., Hoogendoorn S., Dinkelaar J., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2010), Synthesis of Oligoribonucleic Acid Conjugates Using a Cyclooctyne Phosphoramidite, 12(23): .
- Van der Heden Van Noort G.J., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2010), Synthesis of nucleotidylated poliovirus VPg proteins, Journal of Organic Chemistry (JOC) 75(16): .
- Bonger K.M., Kapoerchan V.V., Grotenbreg G.M., Van Koppen C.J., Timmers C.M., Van der Marel G.A. & Overkleeft H.S. (2010), Oligoproline helices as structurally defined scaffolds for oligomeric G protein-coupled receptor ligands, Organic and Biomolecular Chemistry 8(8): .
- Screen M., Britton M., Downey S.L., Verdoes M., Voges M.J., Blom A.E., Guerink P.P., Risseeuw M.D., Florea B.I., Van der Linden W.A., Pletnev A.A., Overkleeft H.S. & Kisselev A.F. (2010), The nature of pharmacophore influences active site specificity of proteasome inhibitors, Journal of Biological Chemistry 285(51): 40125-40134.
- Ali A., Van den Berg R.J.B.H.N., Overkleeft H.S., Van der Marel G.A. & Codee J.D.C. (2010), The methylsulfonylethoxymethyl (Msem) as a hydroxyl protecting group in oligosaccharide synthesis, Tetrahedron 66(32): .
- Van der Heden Van Noort G.J., Van der Horst M.G., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2010), Synthesis of mono-ADP-ribosylated oligopeptides using ribosylated amino acid building blocks, Journal of the American Chemical Society 132(14): .
- Geurink P.P., Florea B.I., Van der Marel G.A., Kessler BM & Overkleeft H.S. (2010), Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates, Chemical Communications (46): 9052-9054.
- Risseeuw M.D., Florea B.I., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2010), Sugar amino acid based peptide epoxyketones as potential proteasome inhibitors, Bioorg Chem 38(5): 202-209.
- Willems L.I., Verdoes M., Florea B.I., Van der Marel G.A. & Overkleeft H.S. (2010), Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation, ChemBioChem 11(12): 1769–1781.
- Walvoort M.T., Dinkelaar J., Van den Bos L.J., Lodder G., Overkleeft H.S., Codee J.D. & Van der Marel G.A. (2010), The impact of oxacarbenium ion conformers on the stereochemical outcome of glycosylations, Carbohydrate Research : .
- Kapoerchan V.V., Wiesner M., Hillaert U., Drijfhout J.W., Overhand M., Alard P., Van der Marel G.A., Overkleeft H.S. & Koning F. (2010), Design, synthesis and evaluation of high-affinity binders for the celiac disease associated HLA-DQ2 molecule, Molecular Immunology 47(5): .
- Florea B.I., Verdoes M., Li N., Van der Linden W.A., Geurink P.P., Van den Elst H., Hofmann T., De Ru A., Van Veelen P.A., Tanaka K., Sasaki K., Murata S., Den Dulk H., Brouwer J., Ossendorp F.A., Kisselev A.F. & Overkleeft H.S. (2010), Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t, Chemistry & Biology 17(8): .
- Van der Linden W.A., Geurink P.P., Oskam C., Van der Marel G.A., Florea B.I. & Overkleeft H.S. (2010), Proteasome selectivity towards Michael acceptor containing oligopeptide-based inhibitors, Organic and Biomolecular Chemistry 8(8): .
- Hogendorf W.F., Bos L.J. van den, Overkleeft H.S., Codee J.D. & Marel G.A. van der (2010), Synthesis of an alpha-kojibiosyl substituted glycerol teichoic acid hexamer, Bioorganic & Medicinal Chemistry : .
- Kapoerchan V.V., Knijnenburg A.D., Niamat M., Spalburg E., De Neeling A.J., Nibbering P.H., Mars-Groenendijk R.H., Noort D., Otero J.M., Llamas-Saiz A.L., Van Raaij M.J., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2010), An adamantyl amino acid containing gramicidin S analogue with broad spectrum antibacterial activity and reduced hemolytic activity, Chemistry: a European Journal 16(40): .
- Gu C., Kolodziejek I., Misas-Villamil J., Shindo T., Colby T., Verdoes M., Richau K.H., Schmidt J., Overkleeft H.S. & Van der Hoorn R.A. (2010), Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defense-induced proteasome activities, The Plant Journal 62(1): .
- Geurink P.P., Florea B.I., Li N., Witte M.D., Verasdonck J., Kuo C.L., Van der Marel G.A. & Overkleeft H.S. (2010), A cleavable linker based on the levulinoyl ester for activity-based protein profiling, Angewandte Chemie - International Edition in English 49(38): .
- Walvoort M.T.C., Lodder G., Mazurek J., Overkleeft H.S., Codee J.D.C. & Marel G.A. van der (2009), Equatorial Anomeric Triflates from Mannuronic Acid Esters, Journal of the American Chemical Society 131(34): 12080-+.
- Bonger K.M., Hoogendoorn S., Van Koppen C.J., Timmers C., Overkleeft H.S. & Van der Marel G.A. (2009), Synthesis and Pharmacological Evaluation of Dimeric Follicle-Stimulating Hormone Receptor Antagonists, ChemMedChem 4(12): 2098-2102.
- Tuin A.W., Palachanis D.K., Buizert A., Grotenbreg G.M., Spalburg E., De Neeling A.J., Mars-Groenendijk R.H., Noort D., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2009), Synthesis and Biological Evaluation of Novel Gramicidin S Analogues, European Journal of Organic Chemistry (25): 4231-4241.
- Van Eijk M., Aten J., Biji N., Ottenhoff R., Van Roomen C.P.A.A., Dubbelhuis P.F., Seeman I., Ghauharali-Van der Vlugt K., Overkleeft H.S., Arbeeny C., Groen A.K. & Aerts J. (2009), Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation, Chemistry and Physics of Lipids 160: S14-S14.
- Hillaert W., Verdoes M., Florea B.I., Saragliadis N., Habets K., Kuiper J., Van Calenbergh S., Ossendorp F., Van der Marel G.A., Driessen C. & Overkleeft H.S. (2009), Receptor-Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells, Angewandte Chemie - International Edition in English 48(9): 1629-1632.
- Klein T., Geurink P.P., Overkleeft H.S., Kauffman H. & Bischoff R. (2009), Functional Proteomics on Zinc-Dependent Metalloproteinases using Inhibitor Probes, ChemMedChem 4(2): 164-170.
- Ali A., Berg R.J.B.H.N. van den, Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codee J.D.C. (2009), Methylsulfonylethoxycarbonyl (Msc) and fluorous propylsulfonylethoxycarbonyl (FPsc) as hydroxy-protecting groups in carbohydrate chemistry, Tetrahedron Letters 50(19): 2185-2188.
- Maynard C.J., Bottcher C., Ortega Z., Smith R., Florea B.I., Diaz-Hernandez M., Brundin P., Overkleeft H.S., Li J., Lucas J.J. & Dantuma N.P. (2009), Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment, Proceedings of the National Academy of Sciences 106(33): 13986-13991.
- Bonger K.M., Van den Berg R., Knijnenburg A.D., Heitman L.H., Van Koppen C.J., Timmers C., Overkleeft H.S. & Marel G.A. van der (2009), Discovery of Selective Luteinizing Hormone Receptor Agonists Using the Bivalent Ligand Method, ChemMedChem 4(7): 1189-1195.
- Tuin A.W., Grotenbreg G.M., Spalburg E., De Neeling A.J., Mars-Groenendijk R.H., Van der Marel G.A., Noort D., Overkleeft H.S. & Overhand M. (2009), Structural and biological evaluation of some loloatin C analogues, 17(17): 6233-6240.
- Britton M., Lucas M., Downey S.L., Screen M., Pletnev A.A., Verdoes M., Tokhunts R.A., Amir O., Goddard A.L., Pelphrey P.M., Wrigth D.L., Overkleeft H.S. & Kisselev A.F. (2009), Selective Inhibitor of Proteasome's Caspase-like Sites Sensitizes Cells to Specific Inhibition of Chymotrypsin-like Sites, Chemistry & Biology 16(12): 1278-1289.
- Verdoes M., Florea B.I., Marel G.A. van der & Overkleeft H.S. (2009), Chemical Tools To Study the Proteasome, European Journal of Organic Chemistry (20): 3301-3313.
- Van der Knaap M., Engels E., Busscher H.J., Otero J.M., Llamas-Saiz A.L., Van Raaij M.J., Mars-Groenendijk R.H., Noort D., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2009), Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues, 17(17): 6318-6328.
- Wennekes T., Berg R.J.B.H.N. van den, Boot R.G., Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2009), Glycosphingolipids-Nature, Function, and Pharmacological Modulation, Angewandte Chemie (International Edition) 48(47): 8848-8869.
- Eijk M.C. van, Aten J., Bijl N., Ottenhoff R., Roomen C.P.A.A. van, Dubbelhuis P.F., Seeman I., Ghauharali-Vlugt van der K., Overkleeft H.S., Arbeeny C., Groen A.K. & Aerts J.M.F.G. (2009), Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation, PLoS ONE 4(3): e4723.
- Codee J.D.C., Bos L.J. van den, Jong A.R. de, Dinkelaar J., Lodder G., Overkleeft H.S. & Marel G.A. van der (2009), The Stereodirecting Effect of the Glycosyl C5-Carboxylate Ester: Stereoselective Synthesis of beta-Mannuronic Acid Alginates, Journal of Organic Chemistry (JOC) 74(1): 38-47.
- Ruckrich T., Kraus M., Gogel J., Beck A., Ovaa H., Verdoes M., Overkleeft H.S., Kalbacher H. & Driessen C. (2009), Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells, Leukemia 23(6): 1098-1105.
- Knijnenburg A.D., Spalburg E., De Neelin A.J., Mars-Groenendijk R.H., Noort D., Grotenbreg G.M., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2009), Ring-Extended Derivatives of Gramicidin S with Furanoid Sugar Amino Acids in the Turn Region Have Enhanced Antimicrobial Activity, ChemMedChem 4(12): 1976-1979.
- Kaschani F., Verhelst S.H.L., Van Swieten P.F., Verdoes M., Wong C.S., Wang Z., Kaiser M., Overkleeft H.S., Bogyo M. & Van der Hoorn R.A.L. (2009), Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry', The Plant Journal 57(2): 373-385.
- Dinkelaar J., Gold H., Overkleeft H.S., Codee J.D.C. & Marel G.A. van der (2009), Synthesis of Hyaluronic Acid Oligomers using Chemoselective and One-Pot Strategies, Journal of Organic Chemistry (JOC) 74(11): 4208-4216.
- Risseeuw M.D.P., Van den Berg R., Donker-Koopman W.E., Van der Marel G.A., Aerts J., Overhand M. & Overkleeft H.S. (2009), Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors, Bioorganic and Medicinal Chemistry Letters 19(23): 6600-6603.
- Dinkelaar J., Jong A.R. de, Meer R. van, Somers M., Lodder G., Overkleeft H.S., Codee J.D.C. & Marel G.A. van der (2009), Stereodirecting Effect of the Pyranosyl C-5 Substituent in Glycosylation Reactions, Journal of Organic Chemistry (JOC) 74(14): 4982-4991.
- Codee J.D.C., Jong A.R. de, Dinkelaar J., Overkleeft H.S. & Marel G.A. van der (2009), Stereo selectivity of glycosylations of conformationally restricted mannuronate esters, Tetrahedron 65(18): 3780-3788.
- Clerc J., Florea B.I., Kraus M., Groll M., Huber R., Bachmann A.S., Dudler R., Driessen C., Overkleeft H.S. & Kaiser M. (2009), Syringolin A Selectively Labels the 20 S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines, ChemBioChem 10(16): 2638-2643.
- Risseeuw M.D.P., Van der Marel G.A., Overkleeft H.S. & Overhand M. (2009), Pyranocyclopropanyl sugar amino acids, a new class of constrained (di)peptide isosteres, Tetrahedron Asymmetry 20(6-8): 945-951.
- Weterings J.J., Khan S., Heden Noort G.J. van der, Melief C.J.M., Overkleeft H.S., Burg S.H. van der, Ossendorp F., Marel G.A. van der & Filippov D.V. (2009), 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation, Bioorganic and Medicinal Chemistry Letters 19(8): 2249-2251.
- Tuin A.W., Mol M.A.E., Van den Berg R., Fidder A., Marel G.A. van der, Overkleeft H.S. & Noort D. (2009), Activity-Based Protein Profiling Reveals Broad Reactivity of the Nerve Agent Sarin, Chemical Research in Toxicology 22(4): 683-689.
- Witte M.D., Florea B.I., Verdoes M., Adeyanju O., Van der Marel G.A. & Overkleeft H.S. (2009), O-GlcNAc Peptide Epoxyketones Are Recognized by Mammalian Proteasomes, Journal of the American Chemical Society 131(34): 12064-+.
- Wennekes T., Van den Berg R., Bonger K.M., Donker-Koopman W.E., Ghisaidoobe A., Van der Marel G.A., Strijland A., Aerts J. & Overkleeft H.S. (2009), Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism, Tetrahedron Asymmetry 20(6-8): 836-846.
- Ghisaidoobe A.B.T., Koning M.C. de, Duynstee H.I., Kortenaar P.B.W., Overkleeft H.S., Filippov D.V. & Marel G.A. van der (2008), A two-step sulfurization for efficient solution-phase synthesis of phosphorothioate oligonucleotides, Tetrahedron Letters 49: 3129-3132.
- Jawalekar A.M., Meeuwenoord N.J., Cremers J.G.O., Overkleeft H.S., Marel G.A. van der, Rutjes F.P.J.T. & Delft F. van (2008), Conjugation of Nucleosides and Oligonucleotides by [3+2] Cycloaddition, Journal of Organic Chemistry (JOC) 73(1): 287-290.
- Kapoerchan V., Wiesner M., Overhand M., Marel G.A. van der, Koning F. & Overkleeft H.S. (2008), Design of azidoproline containing gluten peptides to suppress CD4+ T-cell responses associated with Celiac disease, Bioorganic & Medicinal Chemistry 16: 2053.
- Wennekes B., Lang M., Leeman M., Marel G.A. van der, Smits E., Weber M., Wiltenburg J. van, Wolberg M., Aerts J.M.F.G. & Overkleeft H.S. (2008), -scale synthesis of the glucosylceramide synthase inhibitor N-950adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin, Organic Process Research & Development : .
- Verdoes M., Florea B.I., Hillaert U., Willems L.M., Linden W.A. van der, Sae-Heng M., Filippov D.V., Kisselev A.F., Marel G.A. van der & Overkleeft H.S. (2008), Azido-BODIPY acid reveals quantitative Staudinger-Bertozzi ligation in two-step activity based proteasome profiling, ChemBioChem 9: 1735-1738.
- Heden G.J., Noort C.P. van, Verhagen C.P., Horst M.G. van der, Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2008), A versatile one-pot procedure to phosphate monoesters and pyrophosphates using di(p-methoxybenzyl)-N,N-diisopropylphosphoramidite, 10: 4461-4464.
- Khan S., Weterings J.J., Britten C.M., Jong A.R. de, Graafland D., Melief C.J.M., Burg S.H. van der, Marel G.A. van der, Overkleeft H.S., Filippov D.V. & Ossendorp F.A. (2008), Chirality of TLR-2 ligand Pam(3)CysSK(4) in fully synthetic peptide conjugates critically influences the induction of specific CD8(+) T-cells, Molecular Immunology : .
- Fissolo N., Kraus M., Reich M., Ayturan M., Overkleeft H.S., Driessen C. & Weissert R. (2008), Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation, European Journal of Immunology 38(9): 2401-2411.
- Kuijl C., Tuin A.W., Overkleeft H.S. & Neefjes J.J.C. (2008), Reciprocal chemical genetics for swift lead and target identification, Molecular Biosystems 4(10): 1001-1008.
- Kapoerchan V., Wiesner M., Overhand M., Marel G.A. van der, Koning F. & Overkleeft H.S. (2008), Conjugation of nucleosides and oligonucleotides by [3+2] cycloaddition, Bioorganic & Medicinal Chemistry 16(4): 2053-2062.
- Dinkelaar J., Bos L.J. van den, Hogendorf W.F.J., Lodder G., Overkleeft H.S., Codee J.D.C. & Marel G.A. van der (2008), Stereoselective Synthesis of L-Guluronic Acid Alginates, Chemistry: a European Journal 14: 9400-9411.
- Gold H., Delft P. van, Meeuwenoord N.J., Codee J.D.C., Filippov D.V., Eggink G., Overkleeft H.S. & Marel G.A. van der (2008), Synthesis of Sugar Nucleotides by Application of Phosphoramidites, Journal of Organic Chemistry (JOC) 73: 9458-9460.
- Kessler T., Reich M., Jahn G., Tolosa E., Beck A., Kalbacher H., Overkleeft H.S., Schempp S. & Driessen C. (2008), Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levels, Journal of General Virology 89: 2427-2436.
- Kraus M., Malenke E., Gogel J., Muller H., Ruckrich T., Overkleeft H.S., Ovaa H., Koscielniak E., Hartmann J.T. & Driessen C. (2008), Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis, Molecular Cancer Therapeutics 7: 1940-1948.
- Bonger K.M., Berg R.J.B.H.N. van den, Knijnenburg A.D., Heitman L.H., IJzerman A.P., Oosterom J., Timmers C.M., Overkleeft H.S. & Marel G.A. van der (2008), Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core, Bioorganic & Medicinal Chemistry 16(7): 3744-3758.
- Geurink P.P., Klein T., Leeuwenburgh M.A., Marel G.A. van der, Kauffman H., Bischoff R. & Overkleeft H.S. (2008), A peptide hydroxamate library for enrichment of metalloproteinases: towards an affinity- based metalloproteinase profiling protocol, ORGANIC & BIOMOLECULAR CHEMISTRY 6: 1244.
- Bonger K.M., Wennekes T., Filippov D.V., Lodder G., Marel G.A. van der & Overkleeft H.S. (2008), The effect of Lewis acids on the stereochemistry in the Ugi three-component reaction with D-lyxo pyrroline, European Journal of Organic Chemistry : 3678-3688.
- Wennekes T., Lang B., Leeman M., Marel G.A. van der, Smits E., Weber M., Wiltenburg J. van, Wolberg M., Aerts J.M.F.G. & Overkleeft H.S. (2008), Large-scale synthesis of the glucosylceramide synthase inhibitor N[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin, Organic Process Research & Development 12(3): 414-423.
- Abello N., Geurink P.P., Toorn M. van der, Oosterhout A.J.M. van, Lugtenburg J., Marel G.A. van der, Kerstjens H.A.M., Postma D.S., Overkleeft H.S. & Bischoff R. (2008), Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS, Analytical Chemistry 80(23): 9171-9180.
- Kapoerchan V., Wiesner M., Overhand M., Marel G.A. van der, Koning F. & Overkleeft H.S. (2007), Design of azidoproline containing gluten peptides to suppress, Bioorganic & Medicinal Chemistry : .
- Bussink A.P., Swieten P.F. van, Ghauharali K., Scheij S., Eijk M.C. van, Wennekes T., Marel G.A. van der, Boot R.G., Aerts J.M.F.G. & Overkleeft H.S. (2007), N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides, Journal of Lipid Research 48(6): 1417-1421.
- Kuijl C., Savage N.D.L., Marsman M., Tuin A.W., Janssen L., Egan D.A., Ketema M., Nieuwendijk A.M.C.H. van den, Eeden S.J.F. van den, Geluk A., Poot A., Marel G.A. van der, Beijersbergen R.L., Overkleeft H.S., Ottenhoff T.H.M. & Neefjes J.J. (2007), Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1, Nature 450: 725-730.
- Verdoes M., Florea B.I., Linden W.A. van der, Renou D., Nieuwendijk A.M.C.H. van den, Marel G.A. van der & Overkleeft H.S. (2007), Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors, Organic and Biomolecular Chemistry 5(9): 1416-1426.
- Swieten P.F. van, Samuel E., Hernandez R.O., Nieuwendijk A.M.C.H. van den, Leeuwenburgh M.A., Marel G.A. van der, Kessler B.M., Overkleeft H.S. & Kisselev A.F. (2007), A cell-permeable inhilbitor and activity-based probe for the caspase-like activity of the proteasome, Bioorganic and Medicinal Chemistry Letters 17(12): 3402-3405.
- Kraus M., Rueckrich T., Reich M., Gogel J., Beck A., Kammer W., Berkers C.R., Burg D., Overkleeft H.S., Ovaa H. & Driessen C. (2007), Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells, Leukemia 21(1): 84-92.
- Wennekes T., Berg R.J.B.H.N. van den, Donker W., Marel G.A. van der, Donker W., Marel G.A. van der, Strijland A., Aerts J.M.F.G. & Overkleeft H.S. (2007), Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man, Journal of Organic Chemistry (JOC) 72(4): 1088-1097.
- Aerts J.M.F.G., Ottenhoff R., Powlson A.S., Grefhorst A., Eijk M. van, Dubbelhuis P.F., Aten J., Kuipers F., Serlie M.J., Wennekes T., Sethi J.K., O'Rahilly S. & Overkleeft H.S. (2007), Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity, Diabetes 56(5): 1341-1349.
- Litjens R.E.J.N., Bos L.J. van den, Codee J.D.C., Overkleeft H.S. & Marel G.A. van der (2007), The use of cyclic bifunctional protecting groups in oligosaccharide synthesis - an overview, Carbohydrate Research 342(3-4): 419-429.
- Marel G.A. van der, Bos L.J. van den, Overkleeft H.S., Litjens R.E.J.N. & Codee J.D.C. (2007), Sequential Glycosylation Strategies: A Focus on Thioglycosides as Donors and Acceptors, FRONTIERS IN MODERN CARBOHYDRATE CHEMISTRY 960: 190-208.
- Ottenhoff T.H.M., Savage N.D.L., Sahiratmadja E., Joosten S.A., Kuyl C., Overkleeft H.S., Neefjes J.J., Meijgaarden K.E. van, Boer T. de & Geluk A. (2007), Immunoregulation and suppression in human tuberculosis. [overig].
- Bonger K.M., Berg R.J.B.H.N. van den, Heitman L.H., IJzerman A.P., Oosterom J., Timmers C.M., Overkleeft H.S. & Marel G.A. van der (2007), Synthesis and evaluation of homo-bivalent GnRHR ligands, Bioorganic & Medicinal Chemistry 15(14): 4841-4856.
- Boot R.G., Verhoek M., Donker-Koopman W., Strijland A., Marle J. van, Overkleeft H.S., Wennekes T. & Aerts J.M.F.G. (2007), Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2, Journal of Biological Chemistry 282(2): 1305-1312.
- Khan S., Bijker M.S., Weterings J.J., Tanke H.J., Adema G.J., Hall T. van, Drijfhout J.W., Melief C.J.M., Overkleeft H.S., Marel G.A. van der, Filippov D.V., Burg M.J.M. van der & Ossendorp F. (2007), Distinct Uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells, Journal of Biological Chemistry 282(29): 21145-21159.
- Agrawal P.R., Hofmann M.W., Meeuwenoord N.J., Fillipov D.V., Stalz H., Hulsbergen F.B., Langosch D., Overkleeft H.S. & Groot H.J.M. de (2007), Solid-phase synthesis and purification of a set of uniformly 13C, 15N labelled de novo designed membrane fusogenic peptides, Journal of Peptide Science 13(2): 75-80.
- Bos L.J. van den, Codee J.D.C., Litjens R.E.J.N., Dinkelaar J., Overkleeft H.S. & Marel G.A. van der (2007), Uronic acids in oligosaccharide synthesis, European Journal of Organic Chemistry 24: 3963-3976.
- Yu H., Sliedregt-Bol K.M., Overkleeft H.S., Marel G.A. van der, Berkel T.J.C. van & Biessen E.A.L. (2007), Therapeutic potential of a synthetic peptide inhibitor of nuclear factor of activated T cells as antirestenotic agent, Arteriosclerosis, Thrombosis, and Vascular Biology 26(7): 1531-1537.
- Slegt M., Overkleeft H.S. & et al (2007), Fingerprints of singlet and triplet phenyl cations, European Journal of Organic Chemistry 32: 5364-5375.
- Weterings J.J., Khan S., Kriek N.M.A., Van der Marel G.A., Overkleeft H.S., Ossendorp F., Van der Burg S.H., Drijfhout J.W. & Filippov D.V. (2007), Synthesis of modified and hybrid protein derived biopolymers, Biopolymers 88(4): 576-576.
- Leeuwenburgh M.A., Geurink P.P., Klein T., Kauffman H.F., Marel G.A. van der, Bischoff R. & Overkleeft H.S. (2006), Solid-phase synthesis of succinylhydroxamate peptides: functionalized matrix metalloproteinase inhibitors, 8: 1705-1708.
- Weterings J.J., Khan S., Heden G.J., Drijfhout J.W., Melief C.J.M., Overkleeft H.S., Burg S.H. van der, Ossendorp F.A., Marel G.A. van der & Filippov D.V. (2006), Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines, Bioorganic and Medicinal Chemistry Letters 16(12): 3258-3261.
- Dinkelaar J., Witte M.D., Bos L.J. van den, Overkleeft H.S. & Marel G.A. van der (2006), NIS/TFA: a general method for hydrolyzing thioglycosides, Carbohydrate Research 341: 1723-1729.
- Bonger K.M., Wennekes T., Lavoir S.V.P., Esposito D., Berg R.J.B.H.N. van den, Litjens R.E.J.N., Marel G.A. van der & Overkleeft H.S. (2006), Transformation of carbohydrate derived 4-azidopentanals into highly functionalized pyrrolidines via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction, QSAR & Combinatorial Science 25: 491-503.
- Bos L.J. van den, Dinkelaar J., Overkleeft H.S. & Marel G.A. van der (2006), Stereocontrolled synthesis of beta-D-mannuronic acid esters: synthesis of an alginate trisaccharide, Journal of the American Chemical Society 128: 13066-13067.
- Tuin A.W., Siegal G.D., Marel G.A. van der, Overkleeft H.S. & Filippov D.V. (2006), Facile synthesis and application of uniformly-13C, 15N - labeled phosphotyrosine for ligand binding studies, Bioorganic and Medicinal Chemistry Letters 16(14): 3806-3808.
- Grotenbreg G.M., Buizert A.E.M., Llamas-Saiz A.L., Spalburg E., Hooft P.A.V. van, Neeling A.J., Noort D., Raaij M.J. van, Marel G.A. van der, Overkleeft H.S. & Overhand M. (2006), Beta-Turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product, Journal of the American Chemical Society 128: 7559-7565.
- Risseeuw M.D.P., Grotenbreg G.M., Witte M.D., Tuin A.W., Leeuwenburgh M.A., Marel G.A. van der, Overkleeft H.S. & Overhand M. (2006), The synthesis of cis- and trans-fused bicyclic sugar amino acids, European Journal of Organic Chemistry 17: 3877-3886.
- Comuzzi C., Cogoi S., Overhand M., Marel G.A. van der, Overkleeft H.S. & Xodo L. (2006), Synthesis and biological evaluation of new pentaphyrin macrocycles for photodynamic therapy, Journal of Medicinal Chemistry 49: 196-204.
- Verdoes M., Florea B.I., Menendez-Benito V., Maynard C.J., Witte M.D., Van der Linden W.A., Van den Nieuwendijk A.M., Hofmann T., Berkers C.R., Van Leeuwen F.W., Groothuis T.A., Leeuwenburgh M.A., Ovaa H., Neefjes J.J., Filippov D.V., Van der Marel G.A., Dantuma N.P. & Overkleeft H.S. (2006), A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo, Chemistry & Biology 13(11): 1217-1226.
- Slegt M., Gronheid R., Vlugt D., Ochiai M., Okuyama T., Zuilhof H., Overkleeft H.S. & Lodder G. (2006), Photochemical generation of six- and five-membered cyclic vinyl cations, Journal of Organic Chemistry (JOC) 71: .
- Berg R.J.B.H.N. van den, Boltje T.J., Verhagen C.P., Litjens R.E.J.N., Marel G.A. van der & Overkleeft H.S. (2006), An efficient synthesis of the natural tetrahydrofuran pachastrissamine starting from D-ribo-phytosphingosine, Journal of Organic Chemistry (JOC) 71: 836-839.
- Filippov D.V., Welters M.J.P., Valentijn A.R.P.M., Melief C.J.M., Marel G.A. van der, Burg S.H. van der, Overkleeft H.S. & Drijfhout J.W. (2006), Chemical synthesis of the HPV16 E7 protein, Tetrahedron Letters 47(52): 9349-9352.
- Dulk M. den, Verheij M., Cats A., Jansen E.P., Hartgrink H.H. & Velde C.J.H. van de (2006), The essentials of locoregional control in the treatment of gastric cancer, Scandinavian Journal of Surgery 95: 236-242.
- Roon A.M., Aguilera B., Cuenca F., Remoortere A. van, Marel G.A. van der, Deelder A.M., Overkleeft H.S. & Hokke C.H. (2005), Synthesis and antibody-binding studies of a series of parasite fuco-oligosaccharides, Bioorganic & Medicinal Chemistry 13(10): 3553-3564.
- Codee J.D.C., Stubba B., Schiattarella M., Overkleeft H.S., Boeckel C.A.A. van, Boom J.H. van & Marel G.A. van der (2005), A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy, Journal of the American Chemical Society 127(11): 3767-3773.
- Codee J.D.C., Litjens R.E.J.N., Bos L.J. van den, Overkleeft H.S. & Marel G.A. van der (2005), Thioglycosides in sequential glycosylation strategies, Chemical Society Reviews 34(9): 769-782.
- Litjens R.E.J.N., Bos L.J. van den, Codee J.D.C., Berg R.J.B.H.N. van den, Overkleeft H.S. & Marel G.A. van der (2005), Sulfonium triflate mediated glycosidations of aryl 2-azido-2-deoxy-1-thio-D-mannosides, European Journal of Organic Chemistry (5): 918-924.
- Codee J.D.C., Litjens R.E.J.N., Bos L.J. van den, Overkleeft H.S. & Marel G.A. van der (2005), Thioglycosides in sequential glycosylation strategies, Chemical Society Reviews 34(9): 769-782.
- Litjens R.E.J.N., Hoogerhout P., Filippov D.V., Codee J.D.C., Bos L.J. van den, Berg R.J.B.H.N. van den, Overkleeft H.S. & Marel G.A. van der (2005), Synthesis of an alpha-Gal epitope alpha-D-Galp-(1 -> 3)-beta-D-Galp-(1 -> 4)-beta-D-Glcp NAc-lipid conjugate, Journal of Carbohydrate Chemistry 24(7): 755-769.
- Litjens R.E.J.N., Bos L.J. van den, Codee J.D.C., Berg R.J.B.H.N. van den, Overkleeft H.S. & Marel G.A. van der (2005), Sulfonium triflate mediated glycosidations of aryl 2-azido-2-deoxy-1-thio-D-mannosides, European Journal of Organic Chemistry (5): 918-924.
- Timmer M.S.M., Risseeuw M.D.P., Verdoes M., Filippov D.V., Palisier J.R., Marel G.A. van der, Overkleeft H.S. & Boom J.H. van (2005), Synthesis of functionalized heterocycles via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction, Tetrahedron Asymmetry 16: 177-185.
- Codée J.D.C., Litjens R.E.J.N., Bos L.J. van den, Overkleeft H.S. & Marel G.A. van der (2005), Thioglycosides in sequential glycolysation strategies, Chemical Society Reviews 34: 769-782.
- Ayres L., Grotenbreg G.M., Marel G.A. van der, Overkleeft H.S., Overhand M. & Hest J.C.M. van (2005), Synthesis and controlled polymerisation of a novel Gramicidin S analogue, Macromolecular Rapid Communications 26: 1336-1340.
- Timmer M.S.M., Viciano Chumillas M., Donker-Koopman W.E., Aerts J.M.F.G., Marel G.A. van der, Overkleeft H.S. & Boom J.H. van (2005), Selective cross-metathesis of C-allyl-glycosides, Journal of Carbohydrate Chemistry 24: 335-351.
- Burster T., Beck A., Tolosa E., Schnorrer P., Weissert R., Reich M., Kraus M., Kalbacher H., Häring H.-U., Weber E., Overkleeft H.S. & Driessen C. (2005), Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells, Journal of Immunology : 5940-5949.
- Codée J.D.C., Stuba B., Schiatterella M., Overkleeft H.S., Boeckel C.A.A. van, Boom J.H. van & Marel G.A. van der (2005), A modular strategy towards the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy, Journal of the American Chemical Society 127: 3767-3773.
- El Oualid F., Elst H. van den, Leroy I.M., Pieterman E., Cohen L.H., Burm B.E.A., Overkleeft H.S., Marel G.A. van der & Overhand M. (2005), A combinatorial approach toward the generation of ambiphilic peptide-based inhibitors of protein:geranylgeranyl transferase-1, Journal Of Combinatorial Chemistry 7: 703-713.
- Lastdrager B., Timmer M.S.M., Marel G.A. van der & Overkleeft H.S. (2005), Claisen self-condensation/decarboxylation as the key steps in the synthesis of C2-symmetrical 1,7-dioxaspiro[5.5]undecanes, Tetrahedron Letters 46: 6195-6198.
- Zutphen S.M. van, Stone E.A., Rijt S. van, Robillard M.S., Marel G.A. van der, Overkleeft H.S., Dulk H. den, Brouwer J. & Reedijk J. (2005), Combinatorial discovery of new asymmetric cis platinum anticancer complexes is made possible with solid-phase synthetic methods, Journal of Inorganic Biochemistry 99(10): 2032-2038.
- Zutphen S.M. van, Kraus M., Driessen C., Marel G.A. van der, Overkleeft H.S. & Reedijk J. (2005), Probing the potential of platinum(II) complexes for the inhibition of thiol-dependent enzymatic activity, Journal of Inorganic Biochemistry 99(6): 1384-1389.
- Borodovsky A., Ovaa H., Meester W.J.N., Venanzi E.S., Bogyo M.S., Hekking B.G., Ploegh H.L., Kessler BM & Overkleeft H.S. (2005), Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases, ChemBioChem 6: 287-291.
- El Oualid F., Baktawar J., Leroy I.M., Elst H. van den, Cohen L.H., Marel G.A. van der, Overkleeft H.S. & Overhand M. (2005), Synthesis and biological evaluation of lipophilic Ca1a2L analogues as potential bisubstrate inhibitors of protein: geranylgeranyl transferase-1, Bioorganic & Medicinal Chemistry 13: 1463-1475.
- Litjens R.E.J.N., Heeten R. den, Timmer M.S.M., Overkleeft H.S. & Marel G.A. van der (2005), An expedient synthesis of the repeating unit of the acidic polysaccharide of the bacteriolytic complex of lysoamidase, Chemistry: a European Journal 11: 1010-1016.
- Timmer M.S.M., Verhelst S.H.L., Grotenbreg G.M., Overhand M. & Overkleeft H.S. (2005), Carbohydrates as versatile platforms in the construction of small compound libraries, 77: 1173-1181.
- Litjens R.E.J.N., Bos L.J. van den, Codée J.D.C., Berg R.J.B.H.N. van den, Overkleeft H.S. & Marel G.A. van der (2005), Sulfonium triflate mediated glycosidations of aryl 2-azido-2-deoxy-1-thio-D-mannosides, European Journal of Organic Chemistry : 918-924.
- Grotenbreg G.M., Witte M.D., Hooft P.A.V. van, Spalburg E., Reiß P., Noort D., Neeling A.J., Koert U., Marel G.A. van der, Overkleeft H.S. & Overhand M. (2005), Synthesis and biological evaluation of gramicidin S dimmers, ORGANIC & BIOMOLECULAR CHEMISTRY 3: 233-238.
- Bos L.J. van den, Litjens R.E.J.N., Berg R.J.B.H.N. van den, Overkleeft H.S. & Marel G.A. van der (2005), Preparation of 1-thio uronic acid lactones and their use in oligosaccharide synthesis, 7: 2007-2010.
- Visser P.C. de, Hooft P.A.V. van, Vries A.M. de, Jong A. de, Marel G.A. van der, Overkleeft H.S. & Noort D. (2005), Biological evaluation of Tyr6 and Ser7 modified drosocin analogues, Bioorganic and Medicinal Chemistry Letters 15: 2902-2905.
- Swieten P.F. van, Leeuwenburgh M.A., Kessler B. & Overkleeft H.S. (2005), Bioorthogonal organic chemistry in living cells: novel strategies for labeling biomolecules, ORGANIC & BIOMOLECULAR CHEMISTRY 3: 20-27.
- Welters M.J., Filippov D.V., Eeden S.J.F. van den, Franken K.L.M.C., Nouta J., Valentijn A.R.P.M., Marel G.A. van der & Overkleeft H.S. (2004), Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV 16 E7 in the TC-1 mouse tumour model, Vaccine 23(3): 305-311.
- Swieten P.F. van, Maehr R., Nieuwendijk A.M.C.H. van den, Kessler B.M., Reich M., Wong C.S., Kalbacher H., Leeuwenburgh M.A., Driessen C., Marel G.A. van der, Ploegh H.L. & Overkleeft H.S. (2004), Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases, Bioorganic and Medicinal Chemistry Letters 14(12): 3131-3134.
- Nieuwendijk A.M.C.H. van den, Ghisaidoobe A.B.T., Overkleeft H.S., Brussee J. & Gen A. van der (2004), Conversion of chiral unsaturated cyanohydrins into chiral carba- and heterocycles via ring-closing metathesis, Tetrahedron 60(46): 10385-10396.
- Tromp R.A., Boom S.S.G.E. van, Timmers C.M., Zutphen S. van, Marel G.A. van der, Overkleeft H.S., Boom J.H. van & Reedijk J. (2004), The beta-glucuronyl-based prodrug strategy allows for its application on beta-glucuronyl-platinum conjugates, Bioorganic and Medicinal Chemistry Letters 14(16): 4273-4276.
- Bos L.J. van den, Codee J.D.C., Toorn J.C. van der, Boltje T.J., Boom J.H. van, Overkleeft H.S. & Marel G.A. van der (2004), Thioglycuronides: Synthesis and application in the assembly of acidic oligosaccharides, 6(13): 2165-2168.
- Codee J.D.C., Bos L.J. van den, Litjens R.E.J.N., Overkleeft H.S., Boeckel C.A.A. van, Boom J.H. van & Marel G.A. van der (2004), Chemoselective glycosylations using sulfonium triflate activator systems, Tetrahedron 60(5): 1057-1064.
- Codée J.D., Overkleeft H.S., Marel G.A. van der & Boeckel C.A. van (2004), The synthesis of well-defined heparin and heparan sulfate fragments, Drug Discovery Today: Technologies 1(3): 317-26.
- Timmer M.S.M., Codee J.D.C., Overkleeft H.S., Boom J.H. van & Marel G.A. van der (2004), A tandem ring-closing metathesis cleavable linker system for solid-phase oligosaccharide synthesis, Synlett: Accounts and Rapid Communications in Chemical Synthesis (12): 2155-2158.
- Visser P.C. de, Helden M. van, Filippov D.V., Marel G.A. van der, Drijfhout J.W., Boom J.H. van, Noort D. & Overkleeft H.S. (2003), A novel, base-labile fluorous amine protecting group: synthesis and use as a tag in the purification of synthetic peptides, Tetrahedron Letters 44: 9013-9016.
- Kriek N.M.A.J., Kelly P., Filippov D.V., Meeuwenoord N.J., Marel G.A. van der, Overhand M., Boom J.H. van, Valentijn A. & Overkleeft H.S. (2003), Synthesis of novel tetrahydropyran-based dipeptide isosters by Overman rearrangement of 2,3-didehydroglycosides, European Journal of Organic Chemistry : 2418-2427.
- Timmer M.S.M., Verdoes M., Sliedregt L.A.J.M., Marel G.A. van der, Boom J.H. van & Overkleeft H.S. (2003), The use of a mannitol-derived fused oxacycle as a combinatorial scaffold, Journal of Organic Chemistry (JOC) 68: 9406-9411.
- Well R.M. van, Marinelli L., Erkelens K., Marel G.A. van der, Lavecchia A., Overkleeft H.S., Boom J.H. van, Kessler H. & Overhand M. (2003), Synthesis and structural analysis of cyclic oligomers consisting of furanoid and pyranoid epsilon-sugar amino acids, European Journal of Organic Chemistry : 2303-2313.
- Visser P.C. de, Kriek N.M.A.J., Hooft P.A.V. van, Schepdael A., Filippov D.V., Marel G.A. van der, Overkleeft H.S., Boom J.H. van & Noort D. (2003), Solid-phase synthesis of polymyxin B-1 and analogues via a safety-catch approach, JOURNAL OF PEPTIDE SCIENCE 61: 298-306.
- Leeuwenburgh M.A., Marel G.A. van der, Overkleeft H.S. & Boom J.H. van (2003), From alpha-1,2-anhydrosugars to C-glycosides: The influence of Lewis acids and nucleophiles on the stereochemistry, Journal of Carbohydrate Chemistry 22: 549-564.
- Codee J.D.C., Bos L.J. van den, Litjens R.E.J.N., Overkleeft H.S., Boom J.H. van & Marel G.A. van der (2003), Sequential one-pot glycosylations using1-hydroxyl and 1-thiodonors, 5: 1947-1950.
- Well R.M. van, Overkleeft H.S., Boom J.H. van, Coop A., Wang J.B., Wang H.Y., Marel G.A. van der & Overhand M. (2003), Synthesis of novel sugar amino acids by Curtius rearrangement, Journal of Organic Chemistry (JOC) : 1704-1710.
- Aguilera B., Ghauharali-Van der Vlugt K., Helmond M.T.J., Out J.M.M., Donker-Koopman W.E., Groener J.E.M., Boot R.G., Renkema G.H., Marel G.A. van der, Boom J.H. van, Overkleeft H.S. & Aerts J.M.F.G. (2003), Transglycosidase activity of chitotriosidase - Improved enzymatic assay for the human macrophage chitinase, Journal of Biological Chemistry 278(42): 40911-40916.
- Ovaa H., Swieten P.F. van, Kessler B.M., Leeuwenburgh M.A., Fiebiger E., Nieuwendijk A.M.C.H. van den, Galardy P.J., Marel G.A. van der, Ploegh H.L. & Overkleeft H.S. (2003), Chemistry in living cells: Detection of active proteasomes by a two-step labeling strategy, Angewandte Chemie (International Edition) 42(31): 3626-3629.
- Zutphen S.M. van, Robillard M.S., Marel G.A. van der, Overkleeft H.S., Dulk H. den, Brouwer J. & Reedijk J. (2003), Extending solid phase methods in inorganic synthesis: the first dinuclear platinum complex synthesized via the solid phase, Chemical Communications 2003(5): 634-635.
- Bos L.J. van den, Codée J.D.C., Boom J.H. van, Overkleeft H.S. & Marel G.A. van der (2003), A novel strategy towards the synthesis of orthogonally functionalised 4-aminoglycosides, ORGANIC & BIOMOLECULAR CHEMISTRY 1: 4160.
- Ovaa H., Swieten P.F. van, Kessler B.M., Leeuwenburgh M.A., Fiebiger E., Nieuwendijk A.M.C.H. van den, Galardy P.J., Marel G.A. van der, Ploegh H.L. & Overkleeft H.S. (2003), Chemistry in living cells: Detection of active proteasomes by a two-step labeling strategy, Angewandte Chemie - International Edition in English 42: 3626-3629.
- Codee J.D.C., Litjens R.E.J.N., Heeten R. den, Overkleeft H.S., Boom J.H. van & Marel G.A. van der (2003), Ph2SO/Tf2O: a powerful promotor system in chemoselective glycosylations using thioglycosides, Organical Letters 5: 1519-1522.
- Grotenbreg G.M., Spalburg E., Neeling A. de, Marel G.A. van der, Overkleeft H.S., Boom J.H. van & Overhand M. (2003), Synthesis and biological evaluation of novel turn-modified gramicidin S analogues, Bioorganic & Medicinal Chemistry 11: 2835-2841.
- Well R.M. van, Meijer M.E.A., Overkleeft H.S., Boom J.H. van, Marel G.A. van der & Overhand M. (2003), Synthesis of bridged sugar amino acids: a new entry into conformationally locked delta- and epsilon-amino acids, Tetrahedron 59: 2423-2434.
- Kocks C., Maehr R., Overkleeft H.S., Wang E.W., Iyer L.K., Lennon-Dumenil A.M., Ploegh H.L. & Kessler B.M. (2003), Functional proteomics of the active cysteine protease content in drosophila S2 cells, Molecular and Cellular Proteomics 2: 1188-1197.
- Filippov D.V., Zoelen D.J., Oldfield S.P., Marel G.A. van der, Overkleeft H.S., Drijfhout J.W. & Kluin-Nelemans J.C. (2003), Fluorophilic tagging reagents for solid phase peptide synthesis, Biopolymers 71: 191.
- Kriek N.M.A.J., Hout E. van der, Kelly P., Meijgaarden K.E. van, Geluk A., Ottenhoff T.H.M., Marel G.A. van der, Overhand M., Boom J.H. van, Valentijn A.R.P.M. & Overkleeft H.S. (2003), Synthesis of novel tetrahydropyran-based dipeptide isosters by Overman rearrangement of 2, 3-didehydroglycosides, Eur.J.of Organic Chemistry : 2418-2427.
- Visser P.C. de, Helden M. van, Filippov D.V., Marel G.A. van der, Drijfhout J.W., Boom J.H. van, Noort D. & Overkleeft H.S. (2003), A novel, base-labile fluorous amine protecting group: synthesis and use as a tag in the purification of synthetic peptide, Tetrahedron Letters : 9013-9016.
- Kriek N.M.A.J., Hout E. van der, Kelly P., Meijgaarden K.E. van, Geluk A., Ottenhoff T.H.M., Marel G.A. van der, Overhand M., Boom J.H. van, Valentijn A.R.P.M. & Overkleeft H.S. (2003), Synthesis of novel tetrahydron-based dipeptide isosters by Overman rearrangement of 2, 3 didehydroglycosides, European Journal of Organic Chemistry 13: 2418-2427.
- Greiner A., Lautwein A., Overkleeft H.S., Weber E. & Driessen C. (2003), Activity and subcellular distribution of cathepsins in primary human monocytes, Journal of Leukocyte Biology 72(2): 235-242.
- Well R.M. van, Overkleeft H.S., Marel G.A. van der, Bruss D., Thibault G., Groot P.G. de, Boom J.H. van & Overhand M. (2003), Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors, Bioorganic and Medicinal Chemistry Letters 13(3): 331-334.
- Kessler B., Hong X., Petrovic J., Borodovsky A., Dantuma N.P., Bogyo M.S., Overkleeft H.S., Ploegh H.L. & Glas R. (2003), Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production, Journal of Biological Chemistry 278(12): 10013-10021.
- Wiendl H., Lautwein A., Mitsdorffer M., Krause S., Erfurth S., Wienhold W., Morgalla M., Weber E., Overkleeft H.S., Lochmuller H., Melms A., Tolosa E. & Driessen C. (2003), Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies, Journal of Neuroimmunology 138: 132-143.
- Kwon A.-R., Kessler BM, Overkleeft H.S. & McKay D.B. (2003), Structure and reactivity of an assymetric complex between HsIV and I-domain deleted HsIU, prokaryotic homolog of the eukaryotic proteasome, Journal of Molecular Biology/JMB Online 330: 185.
- Kisselev A.F., Garcia-Calvo M., Overkleeft H.S., Peterson E., Pennington M.W., Ploegh H.L., Thornberry N.A. & Goldberg A.L. (2003), The carpase-like sites of proteasomes: substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites, Journal of Biological Chemistry 278(38): 35869-35877.
- Carstensen E.V., Duynstee H.I., Marel G.A. van der, Boom J.H. van, Nielsen J., Overkleeft H.S. & Overhand M. (2003), Synthesis of highly functionalized piperidines via a tandem retro-Michael-2+3-cycloaddition, Journal of Carbohydrate Chemistry 22: 241-252.
- Verhelst S.H.L., Wiedenhof W., Ovaa H., Marel G.A. van der, Overkleeft H.S., Boeckel C.A.A. van & Boom J.H. van (2002), A stereoselective route towards highly functionalized 4,6-diaminocyclohexene derivatives, Tetrahedron Letters 43: 6451-6455.
- Ovaa H., Stapper C., Marel G.A. van der, Overkleeft H.S., Boom J.H. van & Blechert S. (2002), Ruthenium catalyzed ring rearrangement: a rapid entry to substituted aza- and oxacycles, Tetrahedron 58: 7503-7518.
- Ovaa H., Lastdrager B., Codee J.D.C., Marel G.A. van der, Overkleeft H.S. & Boom J.H. van (2002), A flexible synthesis of cyclopenditol derivatives based on ring-closing metathesis of carbohydrate-derived 1,6-dienes, Journal of the Chemical Society Perkin Transactions 1 21: 2370-2377.
- Lennon-Dumenil A.M., Bakker A.H., Maehr R., Fiebiger E., Overkleeft H.S., Rosemblatt M., Ploegh H.L. & Lagaudriere-Gesbert C. (2002), Analysis of protease activity in live-antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation, The Journal of Experimental Medicine 196(4): 529-539.
- Filippov D.V., Zoelen D.J., Oldfield S.P., Marel G. van der, Overkleeft H.S., Drijfhout J.W. & Boom J. van der (2002), Use of benzyloxycarbonyl(Z)-based fluorophilic tagging reagents in the purification of synthetic peptides, Tetrahedron Letters 43: 7809-7812.
- Lautwein A., Burster T., Lennon-Dumenil A.M., Overkleeft H.S., Weber E., Kalbacher H. & Driessen C. (2002), Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells, European Journal of Immunology 32(12): 3348-3357.
- Sousa M.C., Kessler BM, Overkleeft H.S. & McKay D.B. (2002), Crystal structure of HsIUV complexed with a vinyl sulfone inhibitor: corroboration of a proposed mechanism of allosteric activation of HsIV by HsIU, Journal of Molecular Biology/JMB Online 318: 779-785.
- Filippov D.V., Zoelen D.J., Oldfield S.P., Marel G.A. van der, Overkleeft H.S., Drijfhout J.W. & Boom J.H. van (2002), Use of benzyloxycarbonyl (Z)-based fluorophilic tagging reagents in the purification of synthetic peptides, Tetrahedron Letters 43: 7809-7812.
- Eloualid F., Bruining L.D., Leroy I.M., Cohen L.H., Boom J.H. van, Marel G.A. van der, Overkleeft H.S. & Overhand M. (2002), Synthesis and biological evaluation of protein: geranylgeranyltransferase I inhibitors based on the CaaX box: Incorporation of sugar amino acids as dipeptide isosteres, Helvetica Chimica Acta 85: 3455-3472.
- Berg R.J.B.H.N. van den, Korevaar C.G.N., Marel G.A. van der, Overkleeft H.S. & Boom J.H. van (2002), A simple and low cost synthesis of D-erythro-sphingosine and D-erythro-azidosphingosine from D-ribo-phytosphingosine: glycosphingolipid precursors, Tetrahedron Letters 43: 8409-8412.
- Kessler BM, Tortorella D., Altun M., Kisselev A.F., Fiebiger E, Hekking B.G., Ploegh H.L. & Overkleeft H.S. (2001), Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits, Chemistry & Biology 8: 913-929.
- Lennon-Dumenil A.M., Roberts A., Valentijn K, Driessen C., Overkleeft H.S., Erickson A., Peters P.J., Bikoff E., Ploegh H.L. & Wolf Bryant P. (2001), The p41 isoform of invariant chain is a chaparone for cathepsin L, The EMBO Journal 20: 4055-4065.
- Borodovsky A., Kessler BM, Casagrande R., Overkleeft H.S., Wilkinson KD & Ploegh H.L. (2001), A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14, The EMBO Journal 20: 5187-5196.
- Aguilera Diez M.B., Siegal G.D., Overkleeft H.S., Meeuwenoord N.J., Rutjes F.P.J.T., Hest J.C.M. van, Schoemaker H.E., Marel G.A. van der, Boom J.H. van & Overhand M. (2001), Synthesis and structural analysis of a b-hairpin modified peptide containing a sugar amino acid, European Journal of Organic Chemistry 2001(8): 1541-1574.
- Aguilera Diez M.B., Wolf L.B., Nieczypor P., Rutjes F.P.J.T., Overkleeft H.S., Hest J.C.M. van, Schoemaker H.E., Wang B., Mol J.C., Furstner A., Overhand M., Marel G.A. van der & Boom J.H. van (2001), Synthesis of diaminosuberic acid derivatives via ring-closing alkyne metathesis, Journal of Organic Chemistry (JOC) 66: 3584-3589.
- Kort M. de, Regenbogen A.D., Overkleeft H.S., Challiss R.A.J., Iwata Y., Miyamoto S., Marel G.A. van der & Boom J.H. van (2000), Synthesis and biological evaluation of cyclophostin: A 5 ',6 ''-tethered analog of adenophostin A, Tetrahedron 56: 5915-5928.
- Leeuwenburgh M.A., Litjens R.E.J.N., Codee J.D.C., Overkleeft H.S., Marel G.A. van der & Boom J.H. van (2000), Radical cyclization of sugar-derived beta-(alkynyloxy)acrylates: Synthesis of novel fused ethers, Organical Letters 2: 1275-1277.
- Well R.M. van, Overkleeft H.S., Overhand M., Carstenen E.V., Marel G.A. van der & Boom J.H. van (2000), Parallel synthesis of cyclic sugar amino acid/amino acid hybrid molecules, Tetrahedron Letters 41: 9331-9335.
- Leeuwenburgh M.A., Appeldoorn C.C.M., Hooft P.A.V. van, Overkleeft H.S., Marel G.A. van der & Boom J.H. van (2000), Synthesis of highly functionalised carbohydrate-derived spiroacetals by ring-closing metathesis and Pauson-Khan reaction of ketoglycosidic enynes, European Journal of Organic Chemistry : 873-877.
- Ovaa H., Codee J.D.C., Lastdrager B., Overkleeft H.S., Marel G.A. van der & Boom J.H. van (1999), A versatile approach to the synthesis of highly functionalised carbocycles, Tetrahedron 40: 5063.
- Turner J.J.C., Wilschut N., Overkleeft H.S., Klaffke W., Marel G.A. van der & Boom J.H. van (1999), Mitsunobu glycosylation of nitrobenzenesulfonamides: Novel route to Amadori Rearrangement Products, Tetrahedron Letters 40: 7039.
- Overkleeft H.S., Verhelst S.H.L., Pieterman E.J., Meeuwenoord N.J., Overhand M., Cohen L.H., Marel G.A. van der & Boom J.H. van (1999), Design and synthesis of a protein : farnesyltransferase inhibitor based on sugar amino acids, Tetrahedron Letters 40: 4103.
- Leeuwenburgh M.A., Picasso S., Overkleeft H.S., Marel G.A. van der, Vogel P. & Boom J.H. van (1999), A short and flexible route to aza-beta-(1 -> 6)-C- disaccharides: Selective alpha-glycosidase inhibitors, Eur.J.of Organic Chemistry : 1185.
- Leeuwenburgh M.A., Kulker C., Duynstee H.I., Overkleeft H.S., Marel G.A. van der & Boom J.H. van (1999), A convenient route to cis- and trans-fused bicyclic ethers by ruthenium mediated ring-closing metathesis of diene and enyne carbohydrate derivatives, Tetrahedron 55: 8253.
- Leeuwenburgh M.A., Kulker C., Overkleeft H.S., Marel G.A. van der & Boom J.H. van (1999), Synthesis of a trans-fused tricyclic ehter using a novel differentially protected glucal, SYNLETT (12): 1945-1947.
- Overkleeft H.S., Renkema G.H., Neele J., Vianello P., Hung I.O., Strijland A., Burg A.M. van der, Koomen G.J., Pandit U.K. & Aerts J.M.F.G. (1998), Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase, Journal of Biological Chemistry 273(41): 26522-26527.
- Ovaa H., Codee J.D.C., Lastdrager B., Overkleeft H.S., Marel G.A. van der & Boom J.H. van (1998), A stereoselective and efficient route to (3S,4R,5S)-(+)-4,5-dihydroxy-cyclopent-1-en-3-ylamine: The side chain of the hypermodified nucleoside Q, Tetrahedron Letters 39: 7987-7990.
- Ovaa H., Leeuwenburgh M.A., Overkleeft H.S., Marel G.A. van der & Boom J.H. van (1998), An expeditious route to the synthesis of highly functionalized chiral oxepines from monosaccharides, Tetrahedron Letters 39: 3025-3028.
- Overhand M., Stuivenberg H.R., Pieterman E.J., Cohen L.H., Leeuwen R.E.W. van, Valentijn A.R.P.M., Overkleeft H.S., Marel G.A. van der & Boom J.H. van (1998), Inhibitors of protein:farnesyl transferase and protein: geranylgeranyl transferase I: Synthesis of homologous diphosphonate analogs of isoprenylated pyrophosphate, Bioorganic chemistry 26: 269-282.
- Hooft P.A.V. van, Leeuwenburgh M.A., Overkleeft H.S., Marel G.A. van der, Boeckel C.A.A. van & Boom J.H. van (1998), A novel and flexible synthesis of pyranose spiroacetal derivatives, Tetrahedron Letters 39: 6061-6064.
- Activities to found a spin-out company of Leiden University