Han de Winde
Hoogleraar Molecular and Industrial Biotechnology Director ad interim, Leiden Learning and Innovation Centre, LLInC
- Naam
- Prof.dr. J.H. de Winde
- Telefoon
- +31 71 527 1036
- j.h.de.winde@science.leidenuniv.nl
- ORCID iD
- 0000-0002-7999-9317
Han de Winde is hoogleraar Industriële Biotechnologie aan de Universiteit Leiden. Grondige expertise in microbiële moleculaire biotechnologie en systeembiologie onderzoek en onderwijs op BSc, MSc, PhD en gevorderd niveau. In combinatie met integraal management van onderzoek, ontwikkeling en onderwijs; inclusief effectieve HRM, budget verantwoordelijkheid, strategie ontwikkeling. Voor meer informatie, zie de Engelstalige pagina.
Nieuws
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'Een op de vijf geteste bacteriën bleek in staat om plastic af te breken' -
Drie toegekende onderzoeksprojecten in NWO-XS competitie -
Is dit de toekomst? Efficiënte plastic-recycling door bacteriën -
Leidse promovendus presenteert internationaal studentenevenement -
Leidse studenten brouwen onderzetters van bierafval -
Philip Spinhoven interim Wetenschappelijk Directeur Instituut Psychologie -
Bacteriën die plastic afbreken: Unilever Research Prize voor masterstudent Jo-Anne Verschoor -
Leidse studenten grote winnaar bij internationale biologiewedstrijd iGEM -
Leids alternatief voor plastic microdeeltjes wint tweede prijs in Europese studentenwedstrijd -
Studiejaar Biologie begint met 2020 stuks zwerfvuil minder -
Faculteit W&N opent academisch jaar via livestream in huiselijke setting -
NGL lustrum: elke twee weken een (online) lezing! -
Studententeam bedenkt Suckerspheres: duurzaam alternatief voor microplastic
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Leids iGEM-team wil testkit voor besmettelijke ziektes maken -
NGL presenteert: tweewekelijkse lezingen over corona -
Lisa Bruil wint de Kees Bakker-Prijs -
Parade vol creatieve wetenschapscommunicatie -
Biologiestudente wint Jong Talent afstudeerprijs voor Plantenwetenschappen -
Discussiëren over genetisch gemodificeerde gewassen en menselijke embryo’s -
Studententeam wil huid genezen met inktviseiwit -
Studententeam iGEM Leiden wint goud in Boston -
Bart de Smit vice-decaan Wiskunde en Natuurwetenschappen -
Tranen ontleden om aandoening ‘droge ogen’ op te sporen -
Han de Winde neemt afscheid als vice-decaan faculteit der Wiskunde en Natuurwetenschappen -
Studenten op jacht naar doorbraak in resistentie tegen antibiotica -
Vijftig Tinten Stress -
‘Jullie geven de stad een internationale tint’ -
Twee jaar vrouwennetwerk aan faculteit W&N -
Nieuwe internationale W&N-studenten verkennen Science Campus -
Internationale studenten ontmoeten de Faculteit der Wiskunde en Natuurwetenschappen -
Sfeer proeven en college volgen tijdens Proefstuderen -
Verslag vergadering 991 - 20 november 2014 -
Feestelijke uitreiking Propedeusediploma’s -
Han de Winde nieuwe vice-decaan faculteit der Wiskunde en Natuurwetenschappen
Vakken
Oud-promovendi
Oud-postocs
Hoogleraar Molecular and Industrial Biotechnology Director ad interim, Leiden Learning and Innovation Centre, LLInC
- Wiskunde en Natuurwetenschappen
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Verschoor J., Croese M.R.J., Lakemeier S.E., Mugge A., Burgers C.M.C., Innocenti P., Willemse J.J., Crooijmans M.E., Wezel G.P. van, Ram A.F.J. & Winde J.H. de (2024), Polyester degradation by soil bacteria: identification of conserved BHETase enzymes in Streptomyces, Communications Biology 7: 725.
- Seekles S.J., Brule T. van den, Punt M., Dijksterhuis J., Arentshorst M., Ljadpanahsaravj M., Roseboom W., Meuken G., Ongenae V.M.A., Zwerus J., Ohm R.A., Kramer G.J., Wösten H.A.B., Winde J.H. de & Ram A.F.J. (2023), Compatible solutes determine the heat resistance of conidia, Fungal Biology and Biotechnology 10: 21.
- Verschoor J.A., Kusumawardhani H., Ram A.F.J. & Winde J.H. de (2022), Toward microbial recycling and upcycling of plastics: prospects and challenges, Frontiers in Microbiology 13: 821629.
- Kusumawardhani H., Furtwängler B., Blommestijn M., Kaltenytė A., Poel J.J.A. van der, Kolk J., Hosseini R. & Winde J.H. de (2021), Adaptive laboratory evolution restores solvent tolerance in plasmid-cured Pseudomonas putida S12: a molecular analysis, Applied and Environmental Microbiology 87(9): e00041-21.
- Crooijmans M.E., Delzenne T.O., Hensen T., Darehei M., Winde J.H. de & Heusden G.P.H. van (2021), Cell-to-cell heterogeneity of phosphate gene expression in yeast is controlled by alternative transcription, 14-3-3 and Spl2, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1864(6-7): 194714.
- Brink M. van den, Tandar S.T., Akker T.A.P. van den, Jovikj S., Defourt V., Langelaar T.G.B., Delzenne T.O., Strien K. van, Schonk A.W., Beers A.J.A.M., Golov E., Chong L.J., Bergman G.Ö., Meijdam J.J.W.D. Crooijmans M.E., Claessen D. & Winde J.H. de (2020), Rapidemic, a versatile and label-free DNAzyme-based platform for visual nucleic acid detection. bioRxiv. [working paper].
- Kusumawardhani H., Dijk D., Hosseini R. & Winde J.H. de (2020), Novel toxin-antitoxin module slvT-slvA regulates megaplasmid stability and incites solvent tolerance in Pseudomonas putida S12, Applied and Environmental Microbiology 86(13): e00686-20.
- Kusumawardhani H., Hosseini R. & Winde J.H. de (2020), Comparative analysis reveals the modular functional build-up of megaplasmid pTTS12 of Pseudomonas putida S12: a paradigm for transferable traits, plasmid stability and inheritance?. bioRxiv. [working paper].
- Kusumawardhani H., Hosseini R. & Winde J.H. de (2018), Solvent Tolerance in Bacteria: Fulfilling the Promise of the Biotech Era?, Trends in Biotechnology 36(10): 1025-1039.
- Hosseini R., Kuepper J., Koebbing S., Blank L.M., Wierckx N. & Winde J.H. de (2017), Regulation of solvent tolerance in Pseudomonas putida S12 mediated by mobile elements, Microbial biotechnology 10(6): 1558–1568.
- Volkers R.J.M., Snoek L.B., Ruijssenaars H.J. & Winde J.H. de. (2015), Dynamic Response of Pseudomonas putida S12 to Sudden Addition of Toluene and the Potential Role of the Solvent Tolerance Gene trgI, 10(7): e0132416.
- Kuepper J., Ruijssenaars H.J., Blank L.M., Winde J.H. de & Wierckx N. (2015), Complete genome sequence of solvent-tolerant Pseudomonas putida S12 including megaplasmid pTTS12, Journal of Biotechnology 200: 17-18.
- Flipse S.M., Winde J.H. de., Osseweijer P. & Sanden M.C.A. van der (2014), The wicked problem of Socially Responsible Innovation, EMBO Reports 15(5): 464-464.
- Verhoef S., Gao N., Ruijssenaars H.J. & Winde J.H. de (2014), Crude glycerol as feedstock for the sustainable production of p-hydroxybenzoate by Pseudomonas putida S12, New Biotechnology 31(1): 114-119.
- Flipse S.M., Sanden M.C.A. van der, Radstake M., Winde J.H. de. & Osseweijer P. (2014), The DNA of socially responsible innovation, EMBO Reports 15(2): 134-137.
- Toone E. & Winde J.H. de (2013), Energy biotechnology in 2013: advanced technology development for breakthroughs in fuels and chemicals production, Current Opinion in Biotechnology 24(3): 367-368.
- Li Y. & Winde J.H. de (2013), Systems and synthetic approaches to industrial biotechnology, Biotechnology Journal 8(8): 870-871.
- Bandounas L., Pinkse M., Winde J.H. de & Ruijssenaars H.J. (2013), Identification of a quinone dehydrogenase from a Bacillus sp involved in the decolourization of the lignin-model dye, Azure B, New Biotechnology 30(2): 196-204.
- Meijnen J.P., Winde J.H.de & Ruijssenaars H.J. (2012), Metabolic and Regulatory Rearrangements Underlying Efficient D-Xylose Utilization in Engineered Pseudomonas putida S12, Journal of Biological Chemistry 287(18): 14606-14614.
- Boender L.G.M., Almering M.J.H., Dijk M., Maris A.J.A. van, Winde J.H. de, Pronk J.T. & Daran-Lapujade P. (2011), Extreme calorie restriction and energy source starvation in Saccharomyces cerevisiae represent distinct physiological states, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813(12): 2133-2144.
- Boender L.G.M., Maris A.J.A. van, Hulster E.A.F. de, Almering M.J.H., Klei I.J. van der, Veenhuis M., Winde J.H. de, Pronk J.T. & Daran-Lapujade P. (2011), Cellular responses of Saccharomyces cerevisiae at near-zero growth rates: transcriptome analysis of anaerobic retentostat cultures, FEMS Yeast Research 11(8): 603-620.
- Meijnen J.P., Verhoef S., Briedjlal A.A., Winde J.H. de & Ruijssenaars H.J. (2011), Improved p-hydroxybenzoate production by engineered Pseudomonas putida S12 by using a mixed-substrate feeding strategy, Applied Microbiology and Biotechnology 90(3): 885-893.
- Bandounas L., Wierckx N.J.P., Winde J.H. de & Ruijssenaars H.J. (2011), Isolation and characterization of novel bacterial strains exhibiting ligninolytic potential, BMC Biotechnology 11: 94.
- Meijnen J.P., Winde J.H. de & Ruijssenaars H.J. (2011), Sustainable production of fine chemicals by the solvent-tolerant Pseudomonas putida S12 using lignocellulosic feedstock, International Sugar Journal 113(1345): 24-30.
- Bandounas L., Ballerstedt H., Winde J.H. de & Ruijssenaars H.J. (2011), Redundancy in putrescine catabolism in solvent tolerant Pseudomonas putida S12, Journal of Biotechnology 154(1): 1-10.
- Wierckx N., Koopman F., Ruijssenaars H.J. & Winde J.H. de (2011), Microbial degradation of furanic compounds: biochemistry, genetics, and impact, Applied Microbiology and Biotechnology 92(6): 1095-1105.
- Verhoef S., Ballerstedt H., Volkers R.J.M., Winde J.H. de & Ruijssenaars H.J. (2010), Comparative transcriptomics and proteomics of p-hydroxybenzoate producing Pseudomonas putida S12: novel responses and implications for strain improvement, Applied Microbiology and Biotechnology 87(2): 679-690.
- Koopman F., Wierckx N., Winde J.H. de. & Ruijssenaars H.J. (2010), Efficient whole-cell biotransformation of 5-(hydroxymethyl)furfural into FDCA, 2,5-furandicarboxylic acid, Bioresource Technology 101(16): 6291-6296.
- Wierckx N., Koopman F., Bandounas L., Winde J.H. de & Ruijssenaars H.J. (2010), Isolation and characterization of Cupriavidus basilensis HMF14 for biological removal of inhibitors from lignocellulosic hydrolysate, Microbial biotechnology 3(3): 336-343.
- Volkers R.J.M., Ballerstedt H., Winde J.H. de & Ruijssenaars H.J. (2010), Isolation and genetic characterization of an improved benzene-tolerant mutant of Pseudomonas putida S12, Environmental Microbiology Reports 2(3): 456-460.
- Koopman F., Wierckx N., Winde J.H. de & Ruijssenaars H.J. (2010), Identification and characterization of the furfural and 5-(hydroxymethyl)furfural degradation pathways of Cupriavidus basilensis HMF14, Proceedings of the National Academy of Sciences 107(11): 4919-4924.
- Eunen K. van, Bouwman J., Daran-Lapujade P., Postmus J., Canelas A.B., Mensonides F.I.C., Orij R., Tuzun I., Brink J. van den, Smits G.J., Gulik W.M. van, Brul S., Heijnen J.J., Winde J.H. de, Mattos M.J.T de, Kettner C., Nielsen J., Westerhoff H.V. & Bakker B.M. (2010), Measuring enzyme activities under standardized in vivo-like conditions for systems biology, FEBS Journal 277(3): 749-760.
- Canelas A.B., Harrison N., Fazio A., Zhang J., Pitkanen J.-P., Brink J. van den, Bakker B.M., Bogner L., Bouwman J., Castrillo J.I., Cankorur A., Chumnanpuen P., Daran-Lapujade P., Dikicioglu D., Eunen K. van, Ewald J.C., Heijnen J.J., Kirdar B., Mattila I., Mensonides F.I.C., Niebel A., Penttila M., Pronk J.T., Reuss M., Salusjarvi L., Sauer U., Sherman D., Siemann-Herzberg M., Westerhoff H., Winde J.H. de, Petranovic D., Oliver S.G., Workman C.T., Zamboni N. & Nielsen J. (2010), Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains, Nature Communications 1: 145.
- Meijnen J.P., Winde J.H. de. & Ruijssenaars H.J. (2009), Establishment of Oxidative D-Xylose Metabolism in Pseudomonas putida S12, Applied and Environmental Microbiology 75(9): 2784-2791.
- Verhoef S., Wierckx N., Westerhof R.G.M., Winde J.H. de & Ruijssenaars H.J. (2009), Bioproduction of p-Hydroxystyrene from Glucose by the Solvent-Tolerant Bacterium Pseudomonas putida S12 in a Two-Phase Water-Decanol Fermentation, Applied and Environmental Microbiology 75(4): 931-936.
- Koopman F.W., Winde J.H.de & Ruijssenaars H.J. (2009), C-1 compounds as auxiliary substrate for engineered Pseudomonas putida S12, Applied Microbiology and Biotechnology 83(4): 705-713.
- Brink J. van den, Akeroyd M., Hoeven R. van der, Pronk J.T., Winde J.H. de & Daran-Lapujade P. (2009), Energetic limits to metabolic flexibility: responses of Saccharomyces cerevisiae to glucose-galactose transitions, Microbiology 155: 1340-1350.
- Volkers R.J.M., Ballerstedt H., Ruijssenaars H., Bont J.A.M. de, Winde J.H. de & Wery J. (2009), TrgI, toluene repressed gene I, a novel gene involved in toluene-tolerance in Pseudomonas putida S12, Extremophiles 13(2): 283-297.
- Wielen L.A.M. van der, Winde J.H. de & Lourens G. (2009), BIOT 163-B-Basic: Integrating bioprocess engineering and biological sciences, Abstracts of Papers of the American Chemical Society 238: .
- Sagt C.M.J., Haaft P.J. ten, Minneboo I.M., Hartog M.P., Damveld R.A., Laan J.M. van der, Akeroyd M., Wenzel T.J., Luesken F.A., Veenhuis M., Klei I. van der & Winde J.H. de (2009), Peroxicretion: a novel secretion pathway in the eukaryotic cell, BMC Biotechnology 9: 48.
- Daran-Lapujade P., Daran J.M., Maris A.J.A. van, Winde J.H. de & Pronk J.T. (2009), Chemostat-Based Micro-Array Analysis in Baker's Yeast, Advances in Microbial Physiology 54: 257-311.
- Wierckx N., Ruijssenaars H.J., Winde J.H. de, Schmid A. & Blank L.M. (2009), Metabolic flux analysis of a phenol producing mutant of Pseudomonas putida S12: Verification and complementation of hypotheses derived from transcriptomics, Journal of Biotechnology 143(2): 124-129.
- Knijnenburg T.A., Daran J.M.G., Broek M.A. van den, Daran-Lapujade P.A.S., Winde J.H. de, Pronk J.T., Reinders M.J.T. & Wessels L.F.A. (2009), Combinatorial effects of environmental parameters on transcriptional regulation in Saccharomyces cerevisiae: A quantitative analysis of a compendium of chemostat-based transcriptome data, BMC Genomics 10: 53.
- Wierckx N.J.P., Ballerstedt H., Bont J.A.M. de, Winde J.H. de, Ruijssenaars H.J. & Wery J. (2008), Transcriptome analysis of a phenol-producing Pseudomonas putida S12 construct: Genetic and physiological basis for improved production, Journal of Bacteriology 190(8): 2822-2830.
- Brink J. van den, Canelas A.B., Gulik W.M. van, Pronk J.T., Heijnen J.J., Winde J.H. de & Daran-Lapujade P. (2008), Dynamics of glycolytic regulation during adaptation of Saccharomyces cerevisiae to fermentative metabolism, Applied and Environmental Microbiology 74(18): 5710-5723.
- Meijnen J.-P., Winde J.H. de & Ruijssenaars H.J. (2008), Engineering Pseudomonas putida S12 for efficient utilization of D-xylose and L-arabinose, Applied and Environmental Microbiology 74(16): 5031-5037.
- Cipollina C., Brink J. van den, Daran-Lapujade P., Pronk J.T., Vai M. & Winde J.H. de (2008), Revisiting the role of yeast Sfp1 in ribosome biogenesis and cell size control: a chemostat study, Microbiology 154: 337-346.
- Cipollina C., Brink J. van den, Daran-Lapujade P., Pronk J.T., Porro D. & Winde J.H. de (2008), Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis, Microbiology 154(6): 1686-1699.
- Brink J. van den, Daran-Lapujade P., Pronk J.T. & Winde J.H. de (2008), New insights into the Saccharomyces cerevisiae fermentation switch: Dynamic transcriptional response to anaerobicity and glucose-excess, BMC Genomics 9: 100.
- Daran-Lapujade P., Rossell S., Gulik W.M. van, Luttik M.A.H., Groot M.J.L.de, Slijper M., Heck A.J.R., Daran J.-M., Winde J.H. de, Westerhoff H.V., Pronk J.T. & Bakker B.M. (2007), The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels, Proceedings of the National Academy of Sciences 104(40): 15753-15758.
- Knijnenburg T.A., Winde J.H. de, Daran J.M., Daran-Lapujade P., Pronk J.T., Reinders M.J.T. & Wessels L.F.A. (2007), Exploiting combinatorial cultivation conditions to infer transcriptional regulation, BMC Genomics 8: 25.
- Pel H.J., Winde J.H. de, Ram A.F.J., Hondel C.A.M.J.J. van den, Vondervoort P.J.I. van de & et al. (2007), Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88, Nature Biotechnology 25(2): 221-231.
- Boer V.M., Tai S.L., Vuralhan Z., Arifin Y., Walsh M.C., Piper M.D.W., Winde J.H., Pronk J.T. & Daran J.M. (2007), Transcriptional responses of Saccharomyces cerevisiae to preferred and nonpreferred nitrogen sources in glucose-limited chemostat cultures, FEMS Yeast Research 7(4): 604-620.
- Jansen M.L.A., Krook D.J.J., Graaf K. de, Dijken J.P., Pronk J.T. & Winde J.H. de (2006), Physiological characterization and fed-batch production of an extracellular maltase of Schizosaccharomyces pombe CBS 356, FEMS Yeast Research 6(6): 888-901.
- Hazelwood L.A., Tai S.L., Boer V.M., Winde J.H. de, Pronk J.T. & Daran J.M. (2006), A new physiological role for Pdr12p in Saccharomyces cerevisiae: export of aromatic and branched-chain organic acids produced in amino acid catabolism, FEMS Yeast Research 6(6): 937-945.
- Tai S.L., Boer V.M., Daran-Lapujade P., Walsh M.C., Winde J.H. de, Daran J.M. & Pronk J.T. (2005), Two-dimensional transcriptome analysis in chemostat cultures - Combinatorial effects of oxygen availability and macronutrient limitation in Saccharomyces cerevisiae, Journal of Biological Chemistry 280(1): 437-447.
- Aguilera J., Petit T., Winde J.H. de & Pronk J.T. (2005), Physiological and genome-wide transcriptional responses of Saccharomyees cerevisiae to high carbon dioxide concentrations, FEMS Yeast Research 5(6-7): 579-593.
- Boer V.M., Daran J.M., Almering M.J.H., Winde J.H. de & Pronk J.T. (2005), Contribution of the Saccharomyces cerevisiae transcriptional regulator Leu3p to physiology and gene expression in nitrogen- and carbon-limited chemostat cultures, FEMS Yeast Research 5(10): 885-897.
- Aguilera J., Dijken J.P. van, Winde J.H. de & Pronk J.T. (2005), Carbonic anhydrase (Nce103p): an essential biosynthetic enzyme for growth of Saccharomyces cerevisiae at atmospheric carbon dioxide pressure, Biochemical Journal 391(2): 311-316.
- Jansen M.L.A., Diderich J.A., Mashego M., Hassane A., Winde J.H. de, Daran-Lapujade P. & Pronk J.T. (2005), Prolonged selection in aerobic, glucose-limited chemostat cultures of Saccharomyces cerevisiae causes a partial loss of glycolytic capacity, Microbiology 151: 1657-1669.
- Jansen M.L.A., Daran-Lapujade P., Winde J.H. de, Piper M.D.W. & Pronk J.T. (2004), Prolonged maltose-limited cultivation of Saccharomyces cerevisiae selects for cells with improved maltose affinity and hypersensitivity, Applied and Environmental Microbiology 70(4): 1956-1963.
- Daran-Lapujade P., Jansen M.L.A., Daran J.M., Gulik W. van, Winde J.H. de & Pronk J.T. (2004), Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae - A chemostat culture study, Journal of Biological Chemistry 279(10): 9125-9138.
- Boer V.M., Winde J.H. de, Pronk J.T. & Piper M.D.W. (2003), The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur, Journal of Biological Chemistry 278(5): 3265-3274.
- Boer V., Winde J.H. de, Pronk J. & Piper M. (2003), Transcriptional responses of Saccharomyces cerevisiae to limitations of carbon, nitrogen, phosphorus or sulfur, Yeast 20: S333-S333.
- Jansen M.L.A., Winde J.H. de & Pronk J.T. (2002), Hxt-carrier-mediated glucose efflux upon exposure of Saccharomyces cerevisiae to excess maltose, Applied and Environmental Microbiology 68(9): 4259-4265.
- Rolland F., Wanke V., Cauwenberg L., Ma P., Boles E., Vanoni M., Winde J.H. de, Thevelein J.M. & Winderickx J. (2001), The role of hexose transport and phosphorylation in cAMP signalling in the yeast Saccharomyces cerevisiae, FEMS Yeast Research 1(1): 33-45.
- Hoof C. van, Janssens V., De Baere I., Stark M.J.R., Winde J.H. de, Winderickx J., Thevelein J.M., Merlevede W. & Goris J. (2001), The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations, Experimental Cell Research 264(2): 372-387.
- Bergsma J.C.T., Kasri N.N., Donaton M.C.V., Wever V. de, Tisi R., Winde J.H. de, Martegani E., Thevelein J.M. & Wera S. (2001), PtdIns(4,5)P-2 and phospholipase C-independent Ins(1,4,5)P-3 signals induced by a nitrogen source in nitrogen-starved yeast cells, Biochemical Journal 359(3): 517-523.
- Hoof C. van, Janssens V., Baere I. de, Winde J.H. de, Winderickx J., Dumortier F., Thevelein J.M., Merlevede W. & Goris J. (2000), The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle, Journal of Molecular Biology/JMB Online 302(1): 103-119.
- Rolland F., Winde J.H. de, Lemaire K., Boles E., Thevelein J.M. & Winderickx J. (2000), Glucose-induced cAMP signalling in yeast requires both a G-protein coupled receptor system for extracellular glucose detection and a separable hexose kinase-dependent sensing process, Molecular Microbiology 38(2): 348-358.
- Thevelein J.M., Cauwenberg L., Colombo S., Winde J.H. de, Donation M., Dumortier F., Kraakman L., Lemaire K., Ma P., Nauwelaers D., Rolland F., Teunissen A., Dijck P. van, Versele M., Wera S. & Winderickx J. (2000), Nutrient-induced signal transduction through the protein kinase A pathway and its role in the control of metabolism, stress resistance, and growth in yeast, Enzyme and Microbial Technology 26(9-10): 819-825.
- Kraakman L.S., Winderickx J., Thevelein J.M. & Winde J.H. (1999), Structure-function analysis of yeast hexokinase: structural requirements for triggering cAMP signalling and catabolite repression, Biochemical Journal 343(1): 159-168.
- Hohmann S., Winderickx J., Winde J.H. de, Valckx D. de, Cobbaert P., Luyten K., Meirsman C. de, Ramos J. & Thevelein J.M. (1999), Novel alleles of yeast hexokinase PII with distinct effects on catalytic activity and catabolite repression of SUC2, Microbiology 145: 703-714.
- Thevelein J.M. & Winde J.H. de (1999), Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae, Molecular Microbiology 33(5): 904-918.
- Versele M., Winde J.H. de & Thevelein J.M. (1999), A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2, The EMBO Journal 18(20): 5577-5591.
- Kraakman L., Lemaire K., Ma P.S., Teunissen A.W.R.H., Donaton M.C.V., Dijck P. van, Winderickx J., De Winde J.H. & Thevelein J.M. (1999), A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose, Molecular Microbiology 32(5): 1002-1012.
- Colombo S., Ma P.S., Cauwenberg L., Winderickx J., Crauwels M., Teunissen A., Nauwelaers D., Winde J.H. de, Gorwa M.F., Colavizza D. & Thevelein J.M. (1998), Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae, The EMBO Journal 17(12): 3326-3341.
- Ernandes J.R., De Meirsman C., Rolland F., Winderickx J., Winde J.H. de, Brandao R.L. & Thevelein J.M. (1998), During the initiation of fermentation overexpression of hexokinase PII in yeast transiently causes a similar deregulation of glycolysis as deletion of Tps1, Yeast 14(3): 255-269.
- Crauwels M., Winderickx J., Winde J.H. de & Thevelein J.M. (1997), Identification of genes with nutrient-controlled expression by PCR-mapping in the yeast Saccharomyces cerevisiae, Yeast 13(10): 973-984.
- Crauwels M., Donaton M.C.V., Pernambuco M.B., Winderickx J., Winde J.H. de & Thevelein J.M. (1997), The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway, Microbiology 143(8): 2627-2637.
- Winderickx J., Winde J.H. de, Crauwels M., Hino A., Hohmann S., VanDijck P. & Thevelein J.M. (1996), Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae: Novel variations of STRE-mediated transcription control?, Molecular and General Genetics 252(4): 470-482.
- Winde J.H. de, Crauwels M., Hohmann S., Thevelein J.M. & Winderickx J. (1996), Differential requirement of the yeast sugar kinases for sugar sensing in establishing the catabolite-repressed state, European Journal of Biochemistry 241(2): 633-643.
- Winde J.H. de, Winderickx J., Hohmann S. & Thevelein J.M. (1995), Role of yeast hexokinases in glucose-induced signaling, glucose repression and control of glycolysis, Journal of Cellular Biochemistry 59(S19A): 337-337.
- Winde J.H. de & Grivell L.A. (1995), Regulation of mitochondrial biogenesis in Saccharomyces cerevisiae, European Journal of Biochemistry 233(1): 200-208.
- Mulder W., Winkler A.A., Scholten I.H.J.M., Zonneveld B.J.M., Winde J.H. de, Steensma Y. & Grivell L.A. (1994), Centromere promoter factors (CPF1) of the yeasts Saccharomyces cerevisiae and Kluyveromyces lactis are functionally exchangeable, despite low overall homology, Current Genetics 26(3): 198-207.
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- Member, various Review Committees
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