Nathaniel Martin
Hoogleraar Biologische chemie
- Naam
- Prof.dr. N.I. Martin
- Telefoon
- +31 71 527 2954
- n.i.martin@biology.leidenuniv.nl
Voor meer informatie, zie de Engelse versie.
Promovendi
Postdocs
Nieuws
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De oplossing voor antibioticaresistentie zou weleens onder onze voeten kunnen liggen -
Krachtig nieuw Leids 'superantibioticum' kan resistentie overwinnen -
Dit is de bibliotheek waarvan je niet wist dat je ernaar op zoek was -
Hoe je een oud antibioticum honderd keer krachtiger maakt -
Proof of Concept-subsidies voor vier Leidse onderzoekers -
Van druppeltjes in de vriezer tot het begin van een krachtig nieuw antibioticum -
Antibiotica uit de natuur verbeteren -
Tussenstand in de evolutiewedloop tussen de mens en resistente bacteriën: twee stappen vooruit voor ons -
NWO-beurs voor nieuwe techniek om kanker te bestrijden -
Gepromoveerde Van Groesen: ‘Niks is te gek om te proberen.’ -
Beurstoekenning Martin in Leidsch Dagblad -
ERC beurs voor verder onderzoek moderne, minder giftige antibiotica -
'Extractenbibliotheek is schatkist van de natuur in Zuid-Holland’ -
Burgemeester Lenferink bezoekt Dutch Extract Library -
Samenwerking start zoektocht voor nieuwe antibiotica met NWO beurs -
EPIC Alliance bundelt krachten in strijd tegen antibioticaresistentie -
Nathaniel Martin: waarom genezen antibiotica ons niet meer? -
Slimme variant van antibioticum omzeilt resistentie bij bacteriën
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Als hoogleraar terug naar je eigen basisschool -
Nathaniel Martin in C2W: ‘De meeste cadeautjes zijn al uitgepakt’ -
Nathaniel Martin in Scientias over veelbelovende oplossing tegen antibiotica-resistentie -
Dodelijke infecties nemen toe, nieuwe antibiotica hard nodig -
Nathaniel Martin in de Volkskrant over wc’s in de ruimte -
Nathaniel Martin in Leidsch Dagblad over antibioticaresistentie
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Nathaniel Martin nieuwe IBL-hoogleraar Bio-organische chemie
Stafonderzoekers
Video's & podcast
Hoogleraar Biologische chemie
- Wiskunde en Natuurwetenschappen
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Machushynets V., Al Ayed K., Terlouw R., Du C., Buijs P., Willemse J., Elsayed S., Schill J., Trebosc V.: Pieren M., Alexander F.M., Cochrane S.A., Liles M.R., Medema M.H., Martin N.I. & Wezel G.P. van (2024), Discovery and derivatization of tridecaptin antibiotics with altered host specificity and enhanced bioactivity, ACS Chemical Biology 19(5): 1106-1115.
- Bakker A.T., Kotsogianni I., Avalos Garcia M., Punt J.M., Liu B., Piermarini D., Gagestein B., Slingerland C.J., Zhang L., Willemse J.J., Ghimire L.B., Berg Richard J.H.B.N. van den, Janssen A.P.A., Ottenhoff T.H.M., Boeckel C.A.A. van, Wezel G.P. van, Ghilarov D., Martin N.I. & Stelt M. van der (2024), Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria, Nature Chemistry 16: 1462-1472.
- Groesen E. van, Mons M.W.E., Kotsogianni A.I., Arts M., Tehrani K.H.M.E., Wade N., Lysenko V., Stel F.M., Zwerus J.T., De Benedetti S., Bakker A.T., Chakraborty P., Stelt M. van der, Scheffers D.-J., Gooskens J., Smits W.K., Holden K., Gilmour P., Willemse J.J., Hitchcock C.A., Hasselt J.G.C. van & Schneider T. Martin N.I. (2024), Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity, Science Translational Medicine 16(759): eabo4736.
- Bobylev E.O., Knol R.A., Mathew S., Poole D.A., Kotsogianni I., Martin N.I., Bruin B. de, Kros A. & Reek J.N.H. (2023), In vivo biodistribution of kinetically stable Pt2L nanospheres that show anti-cancer activity, Chemical Science 14(25): 6943-6952.
- Mullowney M.W., Duncan K.R., Elsayed S.S., Garg N., Hooft J.J.J. van der, Martin N.I., Meijer D., Terlouw B.R., Biermann F., Blin K., Durairaj J., Gorostiola González M., Helfrich E.J.N., Huber F., Leopold-Messer S., Rajan K., Rond T. de, Santen J.A. van, Sorokina M., Balunas M.J., Beniddir M.A., Bergeijk D.A. van, Carroll L.M., Clark C.M., Clevert D.A., Dejong C.A., Du C., Ferrinho S., Grisoni F., Hofstetter A., Jespers W., Kalinina O.V., Kautsar S.A., Kim H., Leao T.F., Masschelein J., Rees E.R., Reher R., Reker D., Schwaller P., Segler M., Skinnider M.A., Walker A.S., Willighagen E.L., Zdrazil B., Ziemert N., Goss R.J.M., Guyomard P., Volkamer A., Gerwick W.H., Kim H.U., Müller R., Wezel G.P. van, Westen G.J.P. van, Hirsch A.K.H., Linington R.G., Robinson S.L. & Medema M.H. (2023), Artificial intelligence for natural product drug discovery, Nature Reviews Drug Discovery 22: 895-916.
- Fellner M., Walsh A., Dela Ahator S., Aftab N., Sutherland B., Tan E.W., Bakker A.T., Martin N.I., Stelt M. van der & Lentz C.S. (2023), Biochemical and cellular characterization of the function of fluorophosphonate-binding hydrolase H (FphH) in staphylococcus aureus support a role in bacterial stress response, ACS infectious diseases 9(11): 2119-2132.
- Ballantine R.D., Al Ayed U.K., Bann S.J., Hoekstra M., Martin N.I. & Cochrane S.A. (2023), Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity, Journal of Medicinal Chemistry 66(8): 6002-6009.
- Al Ayed U.K., Zamarbide Losada S.D., Machushynets N.V., Terlouw B., Elsayed S.S.M.A., Shill J., Trebos V., Pieren M., Medema M.H., Wezel G.P. van & Martin N.I. (2023), Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability, ACS infectious diseases 9(4): 739-748.
- Meij A. van der, Elsayed S.S.M.A., Willemse J.J., Du C., Wood T.M., Martin N.I., Raaijmakers J.M. & Wezel G.P. van (2023), The plant stress hormone jasmonic acid evokes defensive responses in streptomycetes, 89(11): e01239-23.
- Bakker A.T., Kotsogianni A.I., Mirenda L., Straub V.M., Avalos Garcia M., Berg R.J.B.H.N. van den, Florea B.I., Wezel G.P. van, Janssen A.P.A., Martin N.I. & Stelt M. van der (2023), Chemical proteomics reveals antibiotic targets of oxadiazolones in MRSA, Journal of the American Chemical Society 145(2): 1136-1143.
- Wood T.M., Zeronian M.R., Buijs N.P., Bertheussen K., Abedian H.K., Johnson A.V., Pearce N.M., Lutz M., Kemmink J., Seirsma T., Hamoen L.W., Janssen B.J.C. & Martin N.I. (2022), Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures, Chemical Science 13(10): 2985-2991.
- Al Ayed U.K., Ballantine R.D., Hoekstra M., Bann S.J., Wesseling C.M.J., Bakker A.T., Zhong Z., Li Y.X., Brüchle N.C., Stelt M. van der, Cochrane S.A. & Martin N.I. (2022), Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy, Chemical Science 13(12): 3563-3570.
- Maňásková S.H., Nazmi K., Hof W. van’t, Belkum A. van, Kaman W.E., Martin N.I., Veerman E.C.I. & Bikker F.J. (2022), Natural and synthetic Sortase A substrates are processed by Staphylococcus aureus via different pathways, Bioconjugate Chemistry 33(4): 555-559.
- Zhang Y., Haren M.J. van, Marechal N., Troffer-Charlier N., Cura V., Cavarelli J. & Martin N.I. (2022), A direct assay for measuring the activity and inhibition of coactivator-associated arginine methyltransferase 1, Biochemistry 61(11): 1055-1063.
- Dahdou E., Allander L., Falgenhauer L., Iorga Bogdan I., Lorenzetti S., Marcos-Alcade I., Martin N.I., Martinez-Martinez L., Mingorance J., Naas T., Rubin J.E., Spyrakis F., Tändén T. & Gómez-Peurtas P. (2022), Computational modeling and design of new inhibitors of carbapenemases: a discussion from the EPIC Alliance Network, International Journal of Molecular Sciences 23(17): 9746.
- Versloot R.C.A., Lucas F.L.R., Yakovlieva L., Tadema M.J., Zhang Y., Wood T.M., Martin N.I., Marrink S.J., Walvoort M.T.C. & Maglia G. (2022), Quantification of protein glycosylation using nanopores, Nano Letters 22(13): 5357-5364.
- Groesen E. van, Innocenti P. & Martin N.I. (2022), Recent advances in the development of semisynthetic glycopeptide antibiotics: 2014–2022, ACS infectious diseases 8(8): 1381-1407.
- Wesseling C.M.J. & Martin N.I. (2022), Synergy by perturbing the gram-negative outer membrane: opening the door for gram-positive specific antibiotics, ACS infectious diseases 8(9): 1731-1757.
- Bakker A.T., Kotsogianni A.I., Mirenda L., Straub V.M., Avalos Garcia M., Berg R.J.B.H.N. van den, Florea B.I., Wezel G.P. van, Janssen A.P.A., Martin N.I. & Stelt M. van der (2022), Chemical proteomics reveals antibiotic targets of oxadiazolones in MRSA, Journal of the American Chemical Society 145(2): 1136-1143.
- Slingerland C.J., Wesseling C.M.J., Innocenti P., Westphal K.G.C., Masereeuw R. & Martin N.I. (2022), Synthesis and evaluation of polymyxins bearing reductively labile disulfide-linked lipids, Journal of Medicinal Chemistry 65(23): 15878-15892.
- Slingerland C.J., Kotsogianni A.I., Wesseling C.M.J. & Martin N.I. (2022), Polymyxin stereochemistry and its role in antibacterial activity and outer membrane disruption, ACS infectious diseases 8(12): 2396-2404.
- Wade N., Wesseling C.M.J., Innocenti P., Slingerland C.J., Koningstein G.M., Luirink J. & Martin N.I. (2022), Synthesis and structure–activity studies of β-barrel assembly machine complex inhibitor MRL-494, ACS infectious diseases 8(11): 2242-2252.
- Buijs N., Vlaming H.C., Haren M.J. van & Martin N.I. (2022), Synthetic studies with bacitracin A and preparation of analogues containing alternative zinc binding groups, ChemBioChem 23(24): e202200547.
- Ballantine R.D., Al Ayed U.K., Bann S.J., Hoekstra M., Martin N.I. & Cochrane S.A. (2022), Synthesis and structure–activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine, RSC Medicinal Chemistry 13: 1640-1643.
- Haren M.J. van, Tehrani K.H.M.E., Kotsogianni Teftsoglou A.I., Wade N., Brüchle N.C., Mashayekhi V. & Martin N.I. (2021), Cephalosporin prodrug inhibitors overcome metallo‐β‐lactamase driven antibiotic resistance, Chemistry: a European Journal 27(11): 3806-3811.
- Yakovlieva L., Wood T.M., Kemmink J., Kotsogianni Teftsoglou I., Koller F., Lassak J., Martin N.I. & Walvoort M.T.C. (2021), A β-hairpin epitope as novel structural requirement for protein arginine rhamnosylation, Chemical Science 12(4): 1560-1567.
- Ignacio B.J., Bakkum T., Bonger K.M., Martin N.I. & Kasteren S.I. van (2021), Metabolic labeling probes for interrogation of the host-pathogen interaction, Organic and Biomolecular Chemistry 19(13): 2856-2870.
- Tehrani K.H.M.E., Wade N., Mashayekhi V., Brüchle N.C., Jespers W., Voskuil K., Pesce D., Haren. M.J. van, Westen G.J.P. van & Martin N.I. (2021), Novel cephalosporin conjugates display potent and selective inhibition of imipenemase-type metallo-β-lactamases, Journal of Medicinal Chemistry 64(13): 9141-9151.
- Gao Y., Haren M.J., Buijs N., Innocent I., Zhang Y., Sartini D., Campagna R., Emanuelli M., Parsons R.B., Jespers W., Gutiérrez-de-Terán H., Westen G.J.P. van & Martin N.I. (2021), Potent inhibition of nicotinamide N-Methyltransferase by alkene-linked bisubstrate mimics bearing electron deficient aromatics, Journal of Medicinal Chemistry 64(17): 12938-12963.
- Kotsogianni Teftsoglou A.I, Wood T.M., Alexander F.M., Cochrane S.A. & Martin N.I. (2021), Binding studies reveal phospholipid specificity and its role in the calcium-dependent mechanism of action of daptomycin, ACS infectious diseases 7(9): 2612-2619.
- Groesen E. van, Slingerland C.J., Innocenti P., Mihajlovic M., Masereeuw R. & Martin N.I. (2021), Vancomyxins: vancomycin-polymyxin nonapeptide conjugates that retain anti-gram-positive activity with enhanced potency against gram-negative strains, ACS infectious diseases 7(9): 2746–2754.
- Wade N., Tehrani K.H.M.E., Brüchle N.C., Haren M.J. van, Mashayekhi Vi. & Martin N.I. (2021), Mechanistic investigations of metallo‐β‐lactamase inhibitors: strong zinc binding Is not required for potent enzyme inhibition, ChemMedChem 16(10): 1651-1659.
- Wesseling C.M.J., Slingerland C.J., Veraar S., Lok S. & Martin N.I. (2021), Structure-activity studies with bis-amidines that potentiate Gram-positive specific antibiotics against Gram-negative pathogens, ACS infectious diseases 7(12): 3314-3335.
- Zhang Y., Marechal N., Haren M.J. van, Troffer-Charlier N., Cura V., Cavarelli J. & Martin N.I. (2021), Structural studies provide new insights into the role of lysine acetylation on substrate recognition by CARM1 and inform the design of potent peptidomimetic inhibitors, ChemBioChem 22(24): 3469-3476.
- Haren M.J. van, Zhang Y., Thijssen V., Buijs N.P., Gao Y., Mateuszuk L., Fedak F.A., Kij A., Campagna R., Sartini D., Emanuelli M., Chlopicki S., Jongkees S.A.K. & Martin N.I. (2021), Macrocyclic peptides as allosteric inhibitors of nicotinamide n-methyltransferase (NNMT), RSC Chemical Biology 2(5): 1546-1555.
- Haren M.J. van, Gao Y., Buijs N., Campagna R., Sartini D., Emanuelli M., Mateuszuk L., Kij A., Chlopicki S., Martinez de Castilla P.E., Schiffelers R. & Martin N.I. (2021), Esterase-sensitive prodrugs of a potent bisubstrate inhibitor of Nicotinamide N-Methyltransferase (NNMT) display cellular activity, Biomolecules 11(9): 1357.
- Wood T.M., Slingerland C.J. & Martin N.I. (2021), A convenient chemoenzymatic preparation of chimeric macrocyclic peptide antibiotics with potent activity against gram-negative pathogens, Journal of Medicinal Chemistry 64(15): 10890–10899.
- Tehrani K.H.M.E., Wade N., Mashayekhi V., Brüchle N., Jespers W., Voskuil K., Pesce D., Haren M.J. van, Westen G.J.P. van & Martin N.I. (2021), Novel Cephalosporin conjugates display potent and selective inhibition of Imipenemase-type Metallo-β-Lactamases, Journal of Medicinal Chemistry 64(13): 9141–9151.
- Gao Y., Martin N.I. & Haren M.J. van (2021), Nicotinamide N-Methyl Transferase (NNMT): an emerging therapeutic target, Drug Discovery Today 26(11): 2699-2706.
- Sychantha D., Rotondo C.M., Tehrani K.H.M.E., Martin N.I. & Wright G.D. (2021), Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+, Journal of Biological Chemistry 297(2): 100918.
- Steenhuis M., Ulsen P., Martin N.I. & Luirink J. (2021), A ban on BAM: an update on inhibitors of the β-barrel assembly machinery, FEMS Microbiology Letters 368(11): fnab059.
- Wesseling C.M.J., Wood T.M., Slingerland C.J., Bertheussen K., Lok S. & Martin N.I. (2021), Thrombin-derived peptides potentiate the activity of Gram-positive-specific antibiotics against Gram-negative bacteria, Molecules 26(7): 1954.
- Woude L. van der, Piotrowski M., Klaasse G., Paulus J.K., Krahn D., Ninck S., Kaschani F., Kaiser M., Novák O., Ljung K., Bulder S., Verk M. van, Snoek B.L., Fiers M., Martin N.I., Hoorn R.A.L. van der, Robert S., Smeekens S. & Zanten M. van (2021), The chemical compound ‘Heatin’ stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1‐subfamily of nitrilases, The Plant Journal 106(6): 1523-1540.
- Haren M.J. van, Tehrani K.H.M.E., Kotsogianni I., Wade N., Brüchle N., Mashayekhi V. & Martin N.I. (2021), Cephalosporin prodrug inhibitors overcome metallo-β-lactamase driven antibiotic resistance, Chemistry: a European Journal 27(11): 3806-3811.
- Yakovlieva L., Wood T.M., Kemmink J., Kotsogianni I., Krafczyk R., Lassak J., Martin N.I., Walvoort M.T.C. & Koller F. (2021), A β-hairpin epitope as novel structural requirement for protein arginine rhamnosylation, Chemical Science 12(4): 1560-1567.
- Chiorean S., Antwi I., Carney D.W., Kotsogianni I., Giltrap A.M., Alexander F.M., Cochrane S.A., Payne R.J., Martin N.I., Henninot A. & Vederas J.C. (2020), Dissecting the binding interactions of teixobactin with the bacterial cell‐wall precursor lipid II, ChemBioChem 21(6): 789-792.
- Zhang Y., Haren M.J. van & Martin N.I. (2020), Peptidic transition state analogues as PRMT inhibitors, Methods 175: 24-29.
- Tehrani K.H.M.E., Brüchle N.C., Wade N., Mashayekhi V., Pesce D., Haren M.J. van & Martin N.I. (2020), Small molecule carboxylates inhibit metallo-β-lactamases and resensitize carbapenem-resistant bacteria to meropenem, ACS infectious diseases 6(6): 1366-1371.
- Diehl A., Wood T.M., Gebhard S., Martin N.I. & Fritz G. (2020), The cell envelope stress response of bacillus subtilis towards laspartomycin C, Antibiotics 9(11): 729.
- Tehrani K.H.M.E., Fu H., Brüchle N.C., Mashayekhi V., Prats Luján A., Haren M.J. van, Poelarends G.J. & Martin N.I. (2020), Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-N,N′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1, Chemical Communications 56(20): 3047-3049.
- Wood T.M. & Martin N.I. (2019), The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry, Medchemcomm 10(5): 634-646.
- Heesterbeek D.A.C., Martin N.I., Velthuizen A., Duijst M., Ruyken M., Wubbolts R., Rooijakker S.H.M. & Bardoel B.W. (2019), Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics, Scientific Reports 9: 3074.
- Gao Y., Haren M.J. van, Moret E.E., Rood J.J.M., Sartini D., Salvucci A., Emanuelli M., Craveur P., Babault N., Jin J. & Martin N.I. (2019), Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity, Journal of Medicinal Chemistry 62(14): 6597-6614.
- Brouwer M.S.M., Tehrani K.H.M.E., Rapallini M., Geurts Y., Kant A., Harders F., Mashayekhi V., Martin N.I., Bossers A., Mevius D.J., Wit B. & Veldman K.T. (2019), Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products, Antimicrobial Agents and Chemotherapy 63(6): e02338.
- Wood T.M., Bertheussen K. & Martin N.I. (2019), The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics, Organic and Biomolecular Chemistry 18(3): 514-517.
- Haren M.J. van & Martin N.I. (2019), PRMT Inhibitors. Topics in Medicinal Chemistry. Berlin: Springer. 1-38.
- Lin M-H., Potel C.M., Tehrani K.H.M.E., Heck A.J.R., Martin N.I. & Lemeer S. (2018), A new tool to reveal bacterial signaling mechanisms in antibiotic treatment and resistance, Molecular and Cellular Proteomics 17(12): 2496-2507.
- Tehrani K.H.M.E. & Martin N.I. (2018), β-lactam/β-lactamase inhibitor combinations: an update, MEDCHEMCOMM 9: 1439-1456.
- Bolt H.L., Kleijn L.H.J., Martin N.I. & Cobb S.L. (2018), Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology, Molecules 23(7): 1566.
- Haren M.J. van, Thomas M.G., Sartini D., Barlow D.J., Ramsden D.B., Emanuelli M., Klamt F., Martin N.I. & Parsons R.B. (2018), The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase: Evidence for a novel mechanism of substrate inhibition, International Journal of Biochemistry and Cell Biology 98: 127-136.
- Brown J.I., Koopmans T., Strien J. van, Martin N.I. & Frankel A. (2018), Kinetic analysis of PRMT1 reveals multifactorial processivity and a sequential ordered mechanism, ChemBioChem 19(1): 85-99.
- Bergstrom A., Katko A., Adkins Z.B., Hill J.E., Cheng Z., Burnett M.L., Yang H., Aitha M., Mehaffey M.R., Brodbelt J.S., Tehrani K.H.M.E., Martin N.I., Bonomo R.A., Page R.C., Tierney D.L., Fast W., Wright G.D. & Crowder M.W. (2018), Probing the interaction of Aspergillomarasmine A (AMA) with metallo-β-lactamases NDM-1, VIM-2, and IMP-7, ACS infectious diseases 4(2): 135-145.
- Mena-Barragán T., García-Moreno M.I., Sevšek A., Okazaki T., Nanba E., Higaki K., Martin N.I., Pieters R.J., García Fernández J.M. & Ortiz Mellet C. (2018), Probing the inhibitor versus chaperone properties of sp2-iminosugars towards human β-glucocerebrosidase: A picomolar chaperone for Gaucher disease, Molecules 23(4): 927.
- Paige U.B.A. le, Smits B., Hart P. 't, Lefeber A.W.M., Martin N.I. & Ingen H. van (2017), Weak coupling between magnetically inequivalent spins: the deceptively simple, complicated spectrum of a C-13-labeled trimethylated amine, Journal of Magnetic Resonance 278: 96-103.
- Hajmohammadebrahimtehrani K. & Martin N.I. (2017), Thiol-Containing Metallo-β-Lactamase Inhibitors Resensitize Resistant Gram-Negative Bacteria to Meropenem, ACS infectious diseases 3(10): 711-717.
- Kleijn L.H.J., Vlieg H.C., Wood T.M., Sastre Toraño J., Janssen B.J.C. & Martin N.I. (2017), A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C, Angewandte Chemie (International Edition) 56(52): 16546-16549.
- Sevšek A., Sastre Toraño J., Quarles Ufford L. van, Moret E.E., Pieters R.J. & Martin N.I. (2017), Orthoester Functionalized N-Guanidino Derivatives of 1,5-dideoxy-1,5-imino-D-xylitol as pH-Responsive Inhibitors of β-Glucocerebrosidase, MedChemComm 8(11): 2050-2054.
- Hart P. 't, Wood T.M., Tehrani K.H.M.E., Harten R.M. van, Śleszyńska M., Rentero Rebollo I., Hendrickx A.P.A., Willems R.J.L., Breukink E. & Martin N.I. (2017), De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria, Chemical Science 8(12): 7991-7997.
- Haren M.J. van, Marechal N., Troffer-Charlier N., Cianciulli A., Sardella G., Cavarelli J. & Martin N.I. (2017), Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1, Proceedings of the National Academy of Sciences 114(14): 3625-3630.
- Haren M.J. van, Taig R., Kuppens J., Sastre Toraño J., Moret E.E., Parsons R.B., Sartini D., Emanuelli M. & Martin N.I. (2017), Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state, Organic and Biomolecular Chemistry 15(31): 6656-6667.
- Sevšek A., Šrot L., Rihter J., Čelan M., Quarles Ufford L. van, Moret E.E., Martin N.I. & Pieters R.J. (2017), N-Guanidino Derivatives of 1,5-Dideoxy-1,5-imino-D-xylitol are Potent, Selective, and Stable Inhibitors of β-Glucocerebrosidase, ChemMedChem 12(7): 483-486.
- Kleijn L.H.J. & Martin N.I. (2017), The Cyclic Lipopeptide Antibiotics. In: Fisher J., Mobashery S. & Miller M. (red.), Antibacterials. Topics in Medicinal Chemistry nr. 26. Cham: Springer. 27-53.
- Harten R.M. van, Willems R.J.L., Martin N.I. & Hendrickx A.P.A. (2017), New Compounds, Novel Antimicrobial Therapies?, Trends in Microbiology 25(6): 467-479.
- Oude Blenke E., Sleszynska M., Evers M.J.W., Storm G., Martin N.I. & Mastrobattista E. (2017), Strategies for the activation and release of the membranolytic peptide melittin from liposomes using endosomal pH as a trigger, Bioconjugate Chemistry 28(2): 574-582.
- Cura V., Marechal N., Troffer-Charlier N., Strub J-M., Haren M.J. van, Martin N.I., Cianferani S., Bonnefond L. & Cavarelli J. (2017), Functional insights from structural studies of protein arginine methyltransferase 2, FEBS Journal 284(1): 77-96.
- Veer I.L. van 't, Leloup N.O.L., Egan A.J.F., Janssen B.J.C., Martin N.I., Vollmer W. & Breukink E. (2016), Site-specific immobilization of the peptidoglycan synthase PBP1B on a surface plasmon resonance chip surface, ChemBioChem 17(23): 2250-2256.
- Pagliero R.J., D’Astolfo D.S., Lelieveld D., Pratiwi R.D., Aits S., Jaattela M., Martin N.I., Klumperman J. & Egan D.A. (2016), Discovery of Small Molecules That Induce Lysosomal Cell Death in Cancer Cell Lines Using an Image-Based Screening Platform, ASSAY and Drug Development Technologies 14(8): 489-510.
- Haren M.J. van, Sastre Toraño J., Sartini D., Emanuelli M., Parsons R.B. & Martin N.I. (2016), A rapid and efficient assay for the characterization of substrates and inhibitors of nicotinamide N-methyltransferase, Biochemistry 55(37): 5307-5315.
- Sevšek A., Čelan M., Erjavec B., Quarles Ufford L. van, Sastre Toraño J., Moret E.E., Pieters R.J & Martin N.I. (2016), Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase, Organic and Biomolecular Chemistry 14: 8670-8673.
- Thomas M.G., Sartini D., Emanuelli M., Haren M.J. van, Martin N.I., Mountford D.M., Barlow D.J., Klamt F., Ramsden D.B., Reza M. & Parsons R.B. (2016), Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway, Biochemical Journal 473(19): 3253–3267.
- Kleijn L.H.J., Oppedijk S.F., Hart P. 't, Harten R.M. van, Martin-Visscher L.A., Kemmink J., Breukink E. & Martin N.I. (2016), Total synthesis of Laspartomycin C and characterization of its antibacterial mechanism of action, Journal of Medicinal Chemistry 59(7): 3569–3574.
- Hart P. 't, Oppedijk S.F., Breukink E. & Martin N.I. (2016), New insights into nisin’s antibacterial mechanism revealed by binding studies with synthetic lipid II analogues, Biochemistry 55(1): 232-237.
- Maňásková S.H., Nazmi K., Hof W. van 't, Belkum A. van, Martin N.I., Bikker F.J., Wamel W.J.B. van & Veerman E.C.I. (2016), Staphylococcus aureus Sortase A-mediated incorporation of peptides: Effect of peptide modification on incorporation, PLoS ONE 11(1): e147401.
- Oppedijk S.F., Martin N.I. & Breukink E. (2016), Hit ‘em where it hurts: the growing and structurally diverse family of peptides that target lipid-II, Biochimica et Biophysica Acta (BBA) - Biomembranes 1858(5): 947-957.
- Koopmans T., Wood T.M., Hart P. 't, Kleijn L.H.J., Hendrickx A.P.A., Willems R.J.L., Breukink E. & Martin N.I. (2015), Semisynthetic lipopeptides derived from nisin display antibacterial activity and lipid II-binding on par with that of the parent compound, Journal of the American Chemical Society 137(29): 9382-9389.
- Haren M.J. van, Quarles Ufford L. van, Moret E.E. & Martin N.I. (2015), Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites, Organic and Biomolecular Chemistry 13(2): 549.
- Corradini E., Klaasse G., Leurs U., Heck A.J.R., Martin N.I. & Scholten A. (2015), Charting the interactome of PDE3A in human cells using an IBMX based chemical proteomics approach, Molecular Biosystems 11(10): 2786-2797.
- Oude Blenke E., Klaasse G., Merten H., Plückthun A., Mastrobattista E. & Martin N.I. (2015), Liposome functionalization with copper-free “Click Chemistry”, Journal of Controlled Release 202: 14-20.
- Gruba N., Wysocka M., Brzezińska M., Debowski D., Rolka K., Martin N.I. & Lesner A. (2015), Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome, Analytical Biochemistry 508: 8-45.
- Dekker F.J., Bosch T. van den & Martin N.I. (2014), Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases, Drug Discovery Today 19(5): 654-660.
- Thomas D., Koopmans T., Lakowski T.M., Kreinin H., Bui J.M., Vhuiyan M.I., Martin N.I. & Frankel A. (2014), Protein arginine N-methyltransferase substrate preferences for different N(eta)-substituted arginyl peptides, ChemBioChem 15(11): 1607-1613.
- Mooney C.A., Johnson S.A., Hart P. 't, Quarles Ufford L. van, Haan C.A.M. de, Moret E.E. & Martin N.I. (2014), Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors, Journal of Medicinal Chemistry 57(7): 3154-3160.
- Mohammadi T., Sijbrandi R., Lutters M., Verheul J., Martin N.I., Blaauwen T. den, Kruijff B. de & Breukink E. (2014), Specificity of the transport of lipid II by FtsW in Escherichia coli, Journal of Biological Chemistry 289: 14707-14718.
- Hart P. 't, Kleijn L.H.J., Bruin G. de, Oppedijk S.F., Kemmink J. & Martin N.I. (2014), A combined solid- and solution-phase approach provides convenient access to analogues of the calcium-dependent lipopeptide antibiotics, Organic and Biomolecular Chemistry 12(6): 913-918.
- Hattum H. van, Martin N.I., Ruijtenbeek R. & Pieters R.J. (2013), Development of a microarray detection method for galectin cancer proteins based on ligand binding, Analytical Biochemistry 434(1): 99-104.
- Koopmans T., Haren M. van, Quarles Ufford L. van, Beekman J. & Martin N.I. (2013), A concise preparation of the fluorescent amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine and extension of its utility in solid phase peptide synthesis, Bioorganic & Medicinal Chemistry 21(2): 533.
- Kooij R., Branderhorst H.M., Bonte S., Wieclawska S., Martin N.I. & Pieters R.J. (2013), Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives, Medchemcomm 4(2): 387-393.
- Wandelen L. van, Ameijde J. van, Ismail-Ali A., Quarles Ufford L. van, Vijftigschild L., Beekmans J., Martin N.I., Ruijtenbeek R. & Liskamp R.M.J. (2013), Cell-penetrating bisubstrate-based protein kinase C inhibitors, ACS Chemical Biology 8(7): 1479-1487.
- Koopmans T., Dekker F.J. & Martin N.I. (2012), A photocleavable affinity tag for the enrichment of alkyne-modified biomolecules, RSC Advances 2(6): 2244-2246.
- Hart P. 't, Thomas D., Ommeren R. van, Lakowski T.M., Frankel A. & Martin N.I. (2012), Analogues of the HIV-Tat peptide containing Nη-modified arginines as potent inhibitors of protein arginine N-methyltransferases, Medchemcomm 3(10): 1235-1244.
- Kleijn L.H.J., Müskens F.M., Oppedijk S.F., Bruin G. de & Martin N.I. (2012), A concise preparation of the non-proteinogenic amino acid L-kynurenine, Tetrahedron Letters 53(47): 6430-6432.
- Olrichs N.K., Aarsman M.E.G., Verheul J., Arnusch C.J., Martin N.I., Herve M., Vollmer W., Kruijff B. de, Breukink E. & Blaauwen T.A. den (2011), A novel in vivo cell-wall labeling approach sheds new light on peptidoglycan synthesis in Escherichia coli, ChemBioChem 12(7): 1124-1133.
- Hart P. 't, Lakowski T.M., Thomas D., Frankel A. & Martin N.I. (2011), Peptidic partial-bisubstrates as inhibitors of the protein arginine N-methyltransferases, ChemBioChem 12(9): 1427-1432.
- Lakowski T.M., Hart P. 't, Ahern C.A., Martin N.I. & Frankel A. (2010), Nη-Substituted arginyl peptide inhibitors of protein arginine N-methyltransferases, ACS Chemical Biology 5(11): 1053-1063.
- Martin N.I., Woodward J.J., Winter M.B. & Marletta M.A. (2009), 4,4-Difluorinated analogues of L-arginine and NG-hydroxy-L-arginine as mechanistic probes for nitric oxide synthase, Bioorganic and Medicinal Chemistry Letters 19(6): 1758-1762.
- Woodward J.J., Chang M.M., Martin N.I. & Marletta M.A. (2009), The second step of the nitric oxide synthase reaction: evidence for ferric-peroxo as the active oxidant, Journal of the American Chemical Society 131(1): 297-305.
- Martin N.I. (2009), Concise preparation of tetra-orthogonally protected (2S,6R)-lanthionines, Journal of Organic Chemistry (JOC) 74(2): 946-949.
- Martin N.I., Beeson W.T., Woodward J.J. & Marletta M.A. (2008), NG-Aminoguanidines from primary amines and the preparation of nitric oxide synthase inhibitors, Journal of Medicinal Chemistry 51(4): 924-931.
- Martin N.I. & Liskamp R.M.J. (2008), Preparation of NG-substituted L-arginine analogues suitable for solid phase peptide synthesis, Journal of Organic Chemistry (JOC) 40(8): 7849-7851.
- Pattabiraman V.R., Stymiest J.L., Derksen D.J., Martin N.I. & Vederas J.C. (2007), Multiple on-resin olefin metathesis to form ring expanded analogues of the lantibiotic peptide, lacticin 3147 A2, Organic Letters 9(4): 699-702.
- Martin N.I., Derbyshire E.R. & Marletta M.A. (2007), Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1, Bioorganic and Medicinal Chemistry Letters 17(17): 4938-4941.
- Woodward J.J., Martin N.I. & Marletta M.A. (2007), An Escherichia coli expression-based method for heme Substitution, Nature Methods 4(1): 43-45.
- Martin N.I. & Breukink E. (2007), The expanding role of lipid II as a target for lantibiotics, Future Microbiology 2(5): .
- Martin N.I., Woodward J.J., Winter M.B., Beeson W.T. & Marletta M.A. (2007), Design and synthesis of C5 methylated L-arginine analogues as active site probes for nitric oxide synthase, Journal of the American Chemical Society 129(41): 12563-12570.
- Gursky L.J., Martin N.I., Derksen D.J., Belkum M.J. van, Kaur K., Vederas J.C., Stiles M.E. & McMullen L.M. (2006), Production of piscicolin 126 by Carnobacterium maltaromaticum UAL26 is controlled by temperature and induction peptide concentration, Archives of Microbiology 186: 317-325.
- Martin N.I., Woodward J.J. & Marletta M.A. (2006), NG-Hydroxyguanidines from primary amines, Organic Letters 8(18): 4035-4038.
- Martin N.I., Hu H., Moake M.M., Churey J.J., Whittal R., Worobo R.W. & Vederas J.C. (2003), Isolation, structural characterization and properties of mattacin (polymyxin M), a cyclic peptide antibiotic produced by Paenibacillus kobensis M, Journal of Biological Chemistry 278: 13124-13132.
- Ramtohul Y.K., Martin N.I., Silkin L., James M.N.H. & Vederas J.C. (2002), Synthesis of pseudoxazolones and their inhibition of the 3C cysteine proteinases from hepatitis A virus and human rhinovirus-14, Journal of the Chemical Society Perkin Transactions 1 1(11): 1351-1359.
- Garneau S., Martin N.I. & Vederas J.C. (2002), Two-peptide bacteriocins produced by lactic acid bacteria, Biochimie 84(5-6): 577-592.
- Ramtohul Y.K., Martin N.I., Silkin L., James M.N.G. & Vederas J.C. (2001), Pseudoxazolones, a new class of inhibitors for cysteine proteinases: Inhibition of hepatitis A virus and human rhinovirus 3C proteinases, Chemical Communications 2001(24): 2740-2741.
- Mahaffy P.G., Martin N.I., Newman K.E., Hohn B., Mikula R.J. & Munoz V.A. (1998), Laundry Dryer Lint: A novel matrix for non-intrusive environmental lead screening, Environmental Science and Technology 32(16): 2467-2473.
- Scientific Advisor
- Founder and Scientific Advisor
- Associate Editor Journal of Medicinal Chemistry
- ad hoc referee for numerous scientific journals