Joke Bouwstra
Emeritus hoogleraar Toediening van farmaca
- Naam
- Prof.dr. J.A. Bouwstra
- Telefoon
- +31 71 527 2727
- bouwstra@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-7123-6868
Meer informatie is beschikbaar op de Engelse profielpagina.
Nieuws
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Professor én Ridder: Joke Bouwstra ontvangt Koninklijke Onderscheiding -
Joke Bouwstra krijgt als eerste vrouw de Dr. Saal van Zwanenberg Ereprijs: ‘Prachtig om in een rij van vooraanstaande wetenschappers te staan’ -
Huidziekten beter behandelen dankzij NWA-subsidie van 11,7 miljoen euro -
Pijnloze vaccinaties een stap dichterbij -
Ronald Cramer geïnstalleerd als lid van de Koninklijke Nederlandse Akademie van Wetenschappen -
Joke Bouwstra geïnstalleerd als lid van de Koninklijke Nederlandse Akademie van Wetenschappen -
Prof.dr. Joke Bouwstra en prof.dr. Ronald Cramer benoemd tot leden van de KNAW -
Tiende STW-subsidie voor prof.dr. Joke Bouwstra -
Prof.dr. Joke Bouwstra gelauwerd voor huidonderzoek -
Vaccinatie via neusdruppels in plaats van injectienaalden -
Miljoenen mensen te helpen met nieuwe synthetische huidcrème
Oud-promovendi
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Richard Helder -
Lorretta Uche
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Renate Martins Cardoso
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Mara Leone
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Daphne Boer
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Walter Alexander Boiten
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Arnout Mieremet
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Guangsheng Du
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Tineke Berkers
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Mogbekeloluwa Oluwadamiloju Eweje
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Enamul Haque Mojumdar
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Vincent van Drongelen
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Koen van der Maaden
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Michelle Janssens
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Jeroen van Smeden
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Varsha Sakina Thakoersing
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Suzanne Marleen Bal
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Daniël Groen
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Oliver Ackaert
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Zhi Ding
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Robert Rissmann
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Julia Caussin
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Geertruida Maria Theresia Smijs
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Miranda Wilhelmina de Jager
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Ylva Yvonne Grams
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Akhmad Kharis Nugroho
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Hoang Hirschberg
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Bernard Slütter
Emeritus hoogleraar Toediening van farmaca
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Drug Delivery Technology
- Szachniewicz M.M., Meijgaarden K.E.V., Kavrik E., Jiskoot W., Bouwstra J.A., Haks M.C., Geluk A. & Ottenhoff T.H.M. (2025), Cationic pH-sensitive liposomes as tuberculosis subunit vaccine delivery systems: Effect of liposome composition on cellular innate immune responses, International Immunopharmacology 145: 113782.
- Rousel J., Bergmans M.E., Meulen L.W.J. van der, Pagan L., Bruin D.T. de, Kam M.L. de, Klarenbeek N.B., Bouwstra J.A., Seyger M.M.B., Reek J.M.P.A. van den, Niemeyer-van der Kolk T., Rissmann R., Doorn M.B.A. van & NGID consortium (2024), Guselkumab induction therapy demonstrates long-lasting efficacy in patients with mild psoriasis, results from a randomized, placebo-controlled exploratory clinical trial, Journal of The American Academy of Dermatology 90(2): 395-397.
- Lee J., Neustrup M.A., Slütter B.A., O'Mahony C., Bouwstra J.A. & Maaden K. van der (2024), Intradermal vaccination with PLGA nanoparticles via dissolving microneedles and classical injection needles, Pharmaceutical Research 41: 305–319.
- Szachniewicz M.M., Neustrup M.A., Meijgaarden K.E. van, Jiskoot W., Bouwstra J.A., Haks M.C., Geluk A. & Ottenhoff T.H. (2024), Intrinsic immunogenicity of liposomes for tuberculosis vaccines: effect of cationic lipid and cholesterol, European Journal of Pharmaceutical Sciences 195: 106730.
- Nădăban A., Gooris G.S., Beddoes C.M., Dalgliesh R.M., Malfois M., Demé B. & Bouwstra J.A. (2024), The molecular arrangement of ceramides in the unit cell of the long periodicity phase of stratum corneum models shows a high adaptability to different ceramide head group structures, Biochimica et Biophysica Acta (BBA) - Biomembranes 1866(5): 184324.
- Rousel J., Mergen C., Schoones J.W., Niemeyer-van der Kolk T., Doorn M.B.A. van, Bouwstra J.A., Smeden J. van & Rissmann R. (2024), Similar alterations of the stratum corneum ceramide profile in atopic dermatitis, psoriasis, and ichthyosis: results from a systematic review and meta-analysis, Journal of Investigative Dermatology : .
- Rousel J., Mergen C., Bergmans M.E., Bruijnincx L.J., Kam M.L. de, Klarenbeek N.B., Niemeyer-van der Kolk T., Doorn M.B.A. van, Bouwstra J.A. & Rissmann R. (2024), Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis: results of a randomized controlled trial, Journal of Lipid Research 65(8): 100591.
- Nădăban A., Frame C.O., El Yachioui D., Gooris G.S., Dalgliesh R.M., Malfois M., Iacovella C.R., Bunge A.L., McCabe C. & Bouwstra J.A. (2024), The sphingosine and phytosphingosine ceramide ratio in lipid models forming the short periodicity phase: an experimental and molecular simulation study, Langmuir 40(27): 13794-13809.
- Szachniewicz M.M., Eeden S.J.F. van den, Meijgaarden K.E. van, Franken K.L.M.C., Veen S. van, Geluk A., Bouwstra J.A. & Ottenhoff T.H.M. (2024), Cationic pH-sensitive liposome-based subunit tuberculosis vaccine induces protection in mice challenged with Mycobacterium tuberculosis, European Journal of Pharmaceutics and Biopharmaceutics 203: 114437.
- Shamaprasad P., Nadaban A., Iacovella C.R., Gooris G.S., Bunge A.L., Bouwstra J.A. & McCabe C. (2024), The phase behavior of skin-barrier lipids: a combined approach of experiments and simulations, Biophysical Journal : .
- Rousel J., Mergen C., Bergmans ME., Klarenbeek N.B., Kolk T.N. der, Doorn M.B.A. van, Bouwstra J.A. & Rissmann R. (2024), Lesional Psoriasis is associated with alterations in the Stratum Corneum Ceramide profile and Concomitant decreases in Barrier Function, Experimental Dermatology 33(10): e15185.
- Szachniewicz M.M., Neustrup M.A., Eeden S.J.F. van den, Meijgaarden K.E. van, Franken K.L.M.C., Veen S. van, Koning R.I., Limpens R.W.A.L., Geluk A., Bouwstra J.A. & Ottenhoff T.H.M. (2024), Evaluation of PLGA, lipid-PLGA hybrid nanoparticles, and cationic pH-sensitive liposomes as tuberculosis vaccine delivery systems in a Mycobacterium tuberculosis challenge mouse model - A comparison, International Journal of Pharmaceutics 666: 124842.
- Neustrup M.A., Ottenhoff T.H.M., Jiskoot W., Bouwstra J.A. & Maaden K. van der (2024), A Versatile, Low-Cost Modular Microfluidic System to Prepare Poly(Lactic-co-Glycolic Acid) Nanoparticles With Encapsulated Protein, Pharmaceutical Research : .
- Nadaban A., Rousel J., El Yachioui D., Gooris G.S., Beddoes C.M., Dalgliesh R.M., Malfois M., Rissmann R. & Bouwstra J.A. (2023), Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models, Journal of Lipid Research 64(8): 100400.
- Lee J., Beukema M., Zaplatynska O.A., O'Mahony C., Hinrichs W.L.J., Huckriede A.L.W., Bouwstra J.A. & Maaden K. van der (2023), Efficient fabrication of thermo-stable dissolving microneedle arrays for intradermal delivery of influenza whole inactivated virus vaccine, Biomaterials Science 11(20): 6790-6800.
- Bouwstra J.A., Nădăban A., Bras W., McCabe C., Bunge A. & Gooris G.S. (2023), The skin barrier: an extraordinary interface with an exceptional lipid organization, Progress in Lipid Research 92: 101252.
- Rousel J., Nadaban A., Saghari M., Pagan L., Zhuparris A., Theelen B., Gambrah T., Wall H.E.C. van der, Vreeken R.J., Feiss G.L., Niemeyer-van der Kolk T., Burggraaf J. Doorn M.B.A. van, Bouwstra J.A. & Rissmann R. (2023), Lesional skin of seborrheic dermatitis patients is characterized by skin barrier dysfunction and correlating alterations in the stratum corneum ceramide composition, Experimental Dermatology 33(1): 14952.
- Rousel J., Saghari M., Pagan L., Nadaban A., Gambrah T., Theelen B., Kam M.L. de, Haakman J., Wall H.E.C. van der, Feiss G.L., Niemeyer-van der Kolk T., Burggraaf J., Bouwstra J.A., Rissmann R. & Doorn M.B.A. van (2023), Treatment with the Topical Antimicrobial Peptide Omiganan in Mild-to-Moderate Facial Seborrheic Dermatitis versus Ketoconazole and Placebo: Results of a Randomized Controlled Proof-of-Concept Trial, International Journal of Molecular Sciences 24(18): 14315.
- Lozano Vigario F., Simo Vesperinas I., Depuydt M.A.C., Bot I., Veelen P. van, Bouwstra J.A., Kros A. & Slutter B. (2023), Immunopeptidomic analysis of human atherosclerosis identifies novel ApoB100-derived antigenic drivers of atherosclerosis, Atherosclerosis 379: S8-S9.
- Helder R.W.J., Rousel J., Boiten W.A., Gooris G.S., Nadaban A., Ghalbzouri A. el & Bouwstra J.A. (2023), The effect of PPAR isoform (de)activation on the lipid composition in full-thickness skin models, Experimental Dermatology 32(4): 469-478.
- Egorova E.A., Arias Alpizar G., Vlieg R.C., Gooris G.S., Bouwstra J.A., Noort S.J.T. van, Kros A. & Boyle A.L. (2022), Coating gold nanorods with self-assembling peptide amphiphiles promotes stability and facilitates in vivo two-photon imaging, Journal of Materials Chemistry B 10: 1612-1622.
- Tian Y., Lee J., Maaden K. van der, Bhide Y., Vries-Idema J.J. de, Akkerman R., O'Mahony C., Jiskoot W., Frijlink H.W., Huckriede A.L.W., Hinrichs W.L.J., Bouwstra J.A. & Beukema M. (2022), Intradermal administration of influenza vaccine with trehalose and pullulan-based dissolving microneedle arrays, Journal of Pharmaceutical Sciences 111(4): 1070-1080.
- Beddoes C.M., Gooris G.S., Barlow D.J., Lawrence M.J., Dalgliesh R.M., Malfois M., Demé B. & Bouwstra J.A. (2022), The importance of ceramide headgroup for lipid localisation in skin lipid models, Biochimica et Biophysica Acta (BBA) - Biomembranes 1864(6): 183886.
- Lozano Vigario F., Nagy N.A., The M.H., Sparrius R., Bouwstra J.A., Kros A., Jiskoot W., Jong E.C. de & Slütter B.A. (2022), The use of a staggered herringbone micromixer for the preparation of rigid liposomal formulations allows efficient encapsulation of antigen and adjuvant, Journal of Pharmaceutical Sciences 111(4): 1050-1057.
- Nadaban A., Gooris G.S., Beddoes C.M., Dalgliesh R.M. & Bouwstra J.A. (2022), Phytosphingosine ceramide mainly localizes in the central layer of the unique lamellar phase of skin lipid model systems, Journal of Lipid Research 63(9): 100258.
- Shamaprasad P., Frame C.O., Moore T.C., Yang A., Iacovella C.R., Bouwstra J.A., Bunge A.L. & McCabe C. (2022), Using molecular simulation to understand the skin barrier, Progress in Lipid Research 88: 101184.
- Bogaard E. van den, Ilic D., Dubrac S., Tomic-Canic M., Bouwstra J., Celli A. & Mauro T. (2021), Perspective and consensus opinion: good practices for using organotypic skin and epidermal equivalents in experimental dermatology research, Journal of Investigative Dermatology 141(1): 203-205.
- Uche L.E., Gooris G.S., Bouwstra J.A. & Beddoes C.M. (2021), High concentration of the ester-linked ω-hydroxy ceramide increases the permeability in skin lipid model membranes, Biochimica et Biophysica Acta (BBA) - Biomembranes 1863(1): 183487.
- Jacobse J., Voorde W. ten, Tandon A., Romeijn S.G., Grievink H.W., Maaden K. van der, Esdonk M.J. van, Moes D.J.A.R., Loeff F., Bloem K., Vries A. de, Rispens T., Wolbink G., Kam M. de, Ziagkos D., Moerland M., Jiskoot W., Bouwstra J., Burggraaf J., Schrier L., Rissmann R. & Cate R. ten (2021), Comprehensive evaluation of microneedle-based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial, British Journal of Clinical Pharmacology 87(8): 3162-3176.
- Lee J., Maaden K. van der, Gooris G.S., O'Mahony C., Jiskoot W. & Bouwstra J.A. (2021), Engineering of an automated nano-droplet dispensing system for fabrication of antigen-loaded dissolving microneedle arrays, International Journal of Pharmaceutics 600: 120473.
- Helder R.W.J., Rousel J., Boiten W.A., Gooris G.S., Nadaban A., El Ghalbzouri A. & Bouwstra J.A. (2021), Improved organotypic skin model with reduced quantity of monounsaturated ceramides by inhibiting stearoyl-CoA desaturase-1, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1866(4): 158885.
- Beddoes C.M., Rensen D.E., Gooris G.S., Malfois M. & Bouwstra J.A. (2021), The Importance of Free Fatty Chain Length on the Lipid Organization in the Long Periodicity Phase, International Journal of Molecular Sciences 22(7): 3679.
- Bouwstra. J.A., Helder R.W.J. & El Ghalbzouri A. (2021), Human skin equivalents: impaired barrier function in relation to the lipid and protein properties of the stratum corneum, Advanced Drug Delivery Reviews 175: 113802.
- Mieremet A., Helder R.W.J., Nadaban A., Boiten W.A., Gooris G.S., El Ghalbzouri A. & Bouwstra J.A. (2021), Multitargeted approach for the optimization of morphogenesis and barrier formation in human skin equivalents, International Journal of Molecular Sciences 22(11): 5790.
- Egorova E., Gooris G.S., Luther P., Bouwstra J.A., Kros A. & Boyle A.L. (2021), Self-assembly of thiolated versus non-thiolated peptide amphiphiles, Peptide Science 113(6): e24236.
- Petracca B., Nădăban A., Eeman M., Gooris G.S. & Bouwstra J.A. (2021), Effects of ozone on stratum corneum lipid integrity and assembly, Chemistry and Physics of Lipids 240: 105121.
- Uche L.E., Gooris G.S., Bouwstra J.A. & Beddoes C.M. (2021), Increased levels of short-chain ceramides modify the lipid organization and reduce the lipid barrier of skin model membranes, Langmuir 37(31): 9478-9489.
- Leboux R.J.T., Schipper P., Capel T.M.M. van, Kong L., Maaden K. van der, Kros A., Jiskoot W., Jong E.C. de & Bouwstra J.A. (2021), Antigen uptake after intradermal microinjection depends on antigen nature and formulation, but not on injection depth, Frontiers in Allergy 2: 642788.
- Proksch E., Berardesca E., Misery L., Engblom J. & Bouwstra J.A. (2020), Dry skin management: practical approach in light of latest research on skin structure and function, Journal of Dermatological Treatment 31(7): 716-722.
- Boiten W.A., Smeden J. van & Bouwstra J.A. (2020), The cornified envelope-bound ceramide fraction is altered in patients with atopic dermatitis, Journal of Investigative Dermatology 140(5): 1097-1100.e4.
- Helder R.W.J., Boiten W.A., Dijk R. van, Gooris G.S., El Ghalbzouri A. & Bouwstra J.A. (2020), The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865(2): 158546.
- Martins Cardoso R., Creemers E., Absalah S., Hoekstra M., Gooris G.S., Bouwstra J.A. & Eck M. van (2020), Hyperalphalipoproteinemic scavenger receptor BI knockout mice exhibit a disrupted epidermal lipid barrier, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865(3): 158592.
- Boer D.E.C., Smeden J. van, Al-Khakany H., Melnik E., Dijk R. van, Absalah S., Vreeken R.J., Haenen C.C.P., Lavrijsen A.P.M., Overkleeft H.S., Aerts J.M.F.G. & Bouwstra J.A. (2020), Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865(6): 158673.
- Benne N., Martins Cardoso R., Boyle A.L., Kros A., Jiskoot W., Kuiper J., Bouwstra J., Eck M. van & Slütter B.A. (2020), Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques, Advanced Healthcare Materials 9(10): 2000043.
- Smeden J. van, Al-Khakany H., Wang Y., Visscher D., Stephens N., Absalah S., Overkleeft H.S., Aerts J.M.F.G., Hovnanian A. & Bouwstra J.A. (2020), Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities, Journal of Lipid Research 61(6): 859-869.
- Leone M.L., Romeijn S.G., Du G., Dévédec S.E. Le, Vrieling H., O'Mahony C., Bouwstra J.A. & Kersten G.F.A. (2020), Diphtheria toxoid dissolving microneedle vaccination: Adjuvant screening and effect of repeated-fractional dose administration, International Journal of Pharmaceutics 580: 119182.
- Boer D.E.C. Smeden J. van Bouwstra J.A Aerts J.M.F.G. (2020), Glucocerebrosidase: Functions in and Beyond the Lysosome, Journal of Clinical Medicine 9(3): 736-766.
- Egorova E.A., Rijt M.M.J. van, Sommerdijk N., Gooris G.S., Bouwstra J.A., Boyle A.L. & Kros A. (2020), One Peptide for Them All: Gold Nanoparticles of Different Sizes Are Stabilized by a Common Peptide Amphiphile, ACS Nano 14(5): 5874-5886.
- Beddoes C.M., Gooris G.S., Foglia F., Ahmadi D., Barlow D.J., Lawrence M.J., Deme B. & Bouwstra J.A. (2020), Arrangement of Ceramides in the Skin: Sphingosine Chains Localize at a Single Position in Stratum Corneum Lipid Matrix Models, Langmuir 36(34): 10270-10278.
- Martins Cardoso M., Absalah S., Eck M. van & Bouwstra J.A. (2020), Barrier lipid composition and response to plasma lipids: A direct comparison of mouse dorsal back and ear skin, Experimental Dermatology 29(6): 548-555.
- Leone M., Romeijn S., Slütter B., O'Mahony C., Kersten G. & Bouwstra J.A. (2020), Hyaluronan molecular weight: Effects on dissolution time of dissolving microneedles in the skin and on immunogenicity of antigen, European Journal of Pharmaceutical Sciences 146: 105269.
- Ramos A.P., Gooris G.S., Bouwstra J.A., Molinari M. & Lafleur M. (2020), Raman and AFM-IR chemical imaging of stratum corneum model membranes, Canadian Journal of Chemistry 98: 495-501.
- Boer D.E.C., Mirzaian M., Ferraz M.J., Nadaban A., Schreuder A., Hovnanian A., Smeden J. van, Bouwstra J.A. & Aerts J.M.F.G. (2020), Glucosylated cholesterol in skin: synthetic role of extracellular glucocerebrosidase, Clinica Chimica Acta 510: 707-710.
- Ramos A.P., Bouwstra J.A. & Lafleur M. (2020), Very long chain lipids favor the formation of a homogeneous phase in stratum corneum model membranes, Langmuir 36(46): 13899-13907.
- Mieremet A., Dijk R. van, Gooris G., Bouwstra J.A. & El Ghalbzouri A. (2019), Shedding light on the effects of 1,25-dihydroxyvitamin D3 on epidermal lipid barrier formation in three-dimensional human skin equivalents, Journal of Steroid Biochemistry and Molecular Biology 189: 19-27.
- Cardoso R.M., Creemers E., Absalah S., Gooris G.S., Hoekstra M., Eck M. van & Bouwstra J.A. (2019), Hypercholesterolemia in young adult APOE−/− mice alters epidermal lipid composition and impairs barrier function, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864(7): 976-984.
- Maaden K. van der, Schipper P., Jiskoot W. & Bouwstra J.A. (2019), Chemical Modifications of Gold Surfaces with Basic Groups and a Fluorescent Nanoparticle Adhesion Assay To Determine Their Surface pKa, Langmuir 35(22): 7121-7128.
- Mieremet A., Dijk R. van, Boiten W.A., Gooris G.S., Bouwstra J.A. & El Ghalbzouri A. (2019), Characterization of human skin equivalents developed at body's core and surface temperatures, Journal of Tissue Engineering and Regenerative Medicine 13(7): 1122-1133.
- Berkers M.A.J., Boiten W.A., Absalah S., Smeden J. van, Lavrijsen A.P.M. & Bouwstra J.A. (2019), Compromising human skin in vivo and ex vivo to study skin barrier repair, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864(8): 1103-1108.
- Mieremet A., Vázquez García A., Boiten W., Dijk R. van, Gooris G., Bouwstra J.A. & Ghalbzouri A. El (2019), Human skin equivalents cultured under hypoxia display enhanced epidermal morphogenesis and lipid barrier formation, Scientific Reports 9(1): 7811.
- Uche L.E., Gooris G.S., Beddoes C.M. & Bouwstra J.A. (2019), New insight into phase behavior and permeability of skin lipid models based on sphingosine and phytosphingosine ceramides, Biochimica et Biophysica Acta (BBA) - Biomembranes 1861(7): 1317-1328.
- Boiten W.A., Helder R.W.J., Smeden J. van & Bouwstra J.A. (2019), Selectivity in cornified envelop binding of ceramides in human skin and the role of LXR inactivation on ceramide binding, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864(9): 1206-1213.
- Mieremet A., Boiten W.A., Dijk R. van, Gooris G.S., Overkleeft H.S., Aerts J.M.F.G., Bouwstra J.A. & El Ghalbzouri A. (2019), Unravelling effects of relative humidity on lipid barrier formation in human skin equivalents, Archives of Dermatological Research 311(9): 679-689.
- Uche L.E., Gooris G.S., Bouwstra J.A. & Beddoes C.M. (2019), Barrier Capability of Skin Lipid Models: Effect of Ceramides and Free Fatty Acid Composition, Langmuir 35(47): 15376-15388.
- Mieremet A., Helder R.W.J., Nadaban A., Gooris G.S., Boiten W.A., El Ghalbzouri A. & Bouwstra J.A. (2019), Contribution of Palmitic Acid to Epidermal Morphogenesis and Lipid Barrier Formation in Human Skin Equivalents, International Journal of Molecular Sciences 20(23): 6069.
- Leone M., Priester M.I., Romeijn S., Nejadnik M.R., Mönkäre J., O'Mahony C., Jiskoot W., Kersten G. & Bouwstra J.A. (2019), Hyaluronan-based dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment, European Journal of Pharmaceutics and Biopharmaceutics 134: 49-59.
- Mieremet A., Rietveld M., Dijk R. van, Bouwstra J.A. & El Ghalbzouri A. (2018), Recapitulation of native dermal tissue in a full thickness human skin model using human collagens, Tissue Engineering Part B: Reviews 24(11-12): 873-881.
- Paz Ramos A., Gooris G.S., Bouwstra J.A. & Lafleur M. (2018), Evidence of hydrocarbon nanodrops in highly ordered stratum corneum model membranes, Journal of Lipid Research 59(1): 137-143.
- Chermprapai S., Broere F., Gooris G.S., Schlotter Y.M., Rutten V.P.M.G. & Bouwstra J.A. (2018), Altered lipid properties of the stratum corneum in Canine Atopic Dermatitis, Biochimica et Biophysica Acta (BBA) - Biomembranes 1860(2): 526-533.
- Boiten W.A., Berkers M.A.J., Absalah S., Smeden J. van, Lavrijsen A.P.M. & Bouwstra J.A. (2018), Applying a vernix caseosa based formulation accelerates skin barrier repair by modulating lipid biosynthesis, Journal of Lipid Research 59(2): 250-260.
- Maaden K. van der, Heuts J.M.M., Camps M.G.M., Pontier M.J., Terwisscha van Scheltinga A., Jiskoot W., Ossendorp F.A. & Bouwstra J.A. (2018), Hollow microneedle-mediated micro-injections of a liposomal HPV E7(43-63) synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses, Journal of Controlled Release 269: 347-354.
- Berkers M.A.J., Visscher D., Gooris G.S. & Bouwstra J.A. (2018), Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin, Pharmaceutical Research 35(3): 48-61.
- Berkers M.A.J., Visscher D., Gooris G.S. & Bouwstra J.A. (2018), Degree of Skin Barrier Disruption Affects Lipid Organization in Regenerated Stratum Corneum, Acta Dermato-Venereologica 98(4): 421-427.
- Tu J., Bussmann J., Du G., Gao Y., Bouwstra J.A. & Kros A. (2018), Lipid bilayer-coated mesoporous silica nanoparticles carrying bovine hemoglobin towards an erythrocyte mimic, International Journal of Pharmaceutics 543(1-2): 169-178.
- Gooris G.S., Kamran M., Kros A., Moore D.J. & Bouwstra J.A. (2018), Interactions of dipalmitoylphosphatidylcholine with ceramide-based mixtures, Biochimica et Biophysica Acta (BBA) - Biomembranes 1860(6): 1272-1281.
- Niehues H., Bouwstra J.A., El Ghalbzouri A., Brandner J.M., Zeeuwen P.L.J.M. & Bogaard E.H. van den (2018), 3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function, Experimental Dermatology 27(5): 501-511.
- Mönkare J., Pontier M.J., Kampen E.E.M. van, Du G., Leone M., Romeijn S.G., Nejadnik M.R., O'Mahony C., Slütter B.A., Jiskoot W. & Bouwstra J.A. (2018), Development of PLGA nanoparticle loaded dissolving microneedles and comparison with hollow microneedles in intradermal vaccine delivery, European Journal of Pharmaceutics and Biopharmaceutics 129: 111-121.
- Du G., Leone M., Romeijn S.G., Kersten G.F.A., Jiskoot W. & Bouwstra J.A. (2018), Immunogenicity of diphtheria toxoid and poly(I:C) loaded cationic liposomes after hollow microneedle-mediated intradermal injection in mice, International Journal of Pharmacological Research 547(1-2): 250-257.
- Du G., Woythe L., Maaden K. van der, Leone M., Romeijn S.G., Kros A., Kersten G.F.A., Jiskoot W. & Bouwstra J.A. (2018), Coated and Hollow Microneedle-Mediated Intradermal Immunization in Mice with Diphtheria Toxoid Loaded Mesoporous Silica Nanoparticles, Pharmaceutical Research 35(10): 189.
- Leone M., Oorschot B.H. van, Nejadnik M.R., Bocchino A., Rosato M., Kersten G.F.A., O’Mahony C., Bouwstra J.A. & Maaden K. van der (2018), Universal applicator for digitally-controlled pressing force and impact velocity insertion of microneedles into skin, Pharmaceutics 10(4): 211-219.
- Beddoes C.M., Gooris G.S. & Bouwstra J.A. (2018), Preferential arrangement of lipids in the long-periodicity phase of a stratum corneum matrix model, Journal of Lipid Research 59(12): 2329-2338.
- Berkers T., Van Dijk .L., Absalah S., Smeden J. van & Bouwstra J.A. (2017), Topically applied fatty acids are elongated before incorporation in the stratum corneum lipid matrix in compromised skin, Experimental Dermatology 26(1): 36-43.
- Varypataki E.M., Benne N., Bouwstra J.A., Jiskoot W. & Ossendorp F.A. (2017), Efficient eradication of established tumors in mice with cationic liposome-based synthetic long-peptide vaccines, Cancer Immunology Research 5(3): 222-233.
- Mieremet A., Rietveld M., Absalah S., Smeden J. van, Bouwstra J.A. & El Ghalbzouri A. (2017), Improved epidermal barrier formation in human skin models by chitosan modulated dermal matrices, 12(3): e0174478.
- Tu J., Du G., Reza Nejadnik M., Monkare J.T., Maaden K. van der, Bomans P.H.H., Sommerdijk N.A.J.M., Slutter B., Jiskoot W., Bouwstra J.A. & Kros A. (2017), Mesoporous Silica Nanoparticle-Coated Microneedle Arrays for Intradermal Antigen Delivery, Pharmaceutical Research 34(8): 1693-1706.
- Schipper P., Maaden K. van der, Groeneveld V.G.D., Ruigrok M.J.R., Romeijn S.G., Uleman S., Oomens C., Kersten G.F.A., Jiskoot W. & Bouwstra J.A. (2017), Diphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice, Journal of Controlled Release 262: 28-36.
- Leone M., Monkare J.T., Bouwstra J.A. & Kersten G.F.A. (2017), Dissolving microneedle patches for dermal vaccination, Pharmaceutical Research 34(11): 2223-2240.
- Danso M.O., Boiten W., Drongelen V. van, Meijling K.G., Gooris G., Ghalbzouri A. El, Absalah S., Vreeken R., Kezic S., Smeden J. van, Lavrijsen A.P.M. & Bouwstra J.A. (2017), Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition, Journal of Dermatological Science 88(1): 57-66.
- Niehues H., Tsoi L.C., Krieken D.A. van der, Jansen P.A.M., Oortveld M.A.W., Rodijk-Olthuis D., Vlijmen I.M.J.J. van, Hendriks W.J.A.J., Helder R.W.J., Bouwstra J.A., Bogaard E.H. van den, Stuart P.E., Nair R.P., Elder J.T., Zeeuwen P.L.J.M. & Schalkwijk J. (2017), Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity, Journal of Investigative Dermatology 137(11): 2380-2388.
- Groot A.M. de, Du G., Monkare J.T., Platteel A.C.M., Broere F., Bouwstra J.A. & Sijts A.J.A.M. (2017), Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium, Journal of Controlled Release 266: 27-35.
- Du G., Mohammed Hafez Mohammed Hathout R., Nasr Sayed Aly M., Nejadnik M.R., Tu J., Koning R.I., Koster A.J., Slütter B.A., Kros A., Jiskoot W., Bouwstra J.A. & Monkare J.T. (2017), Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles, Journal of Controlled Release 266: 109-118.
- Schmitt T., Lange S., Sonnenberger S., Dobner B., Deméd B., Neubert R.H.H., Gooris G. & Bouwstra J.A. (2017), Determination of the influence of C24 D/(2R)- and L/(2S)-isomers of the CER[AP] on the lamellar structure of stratum corneum model systems using neutron diffraction, Chemistry and Physics of Lipids 209: 29–36.
- Smeden J. van, Dijkhoff I.M., Helder R.W.J., Al-Khakany H., Boer D.E.C., Schreuder A., Kallemeijn W.W., Absalah S., Overkleeft H.S., Aerts J.M.F.G. & Bouwstra J.A. (2017), In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling, Journal of Lipid Research 58(12): 2299-2309.
- Schipper P., Maaden K. van der, Romeijn S., Oomens C., Kersten G., Jiskoot W. & Bouwstra J. (2016), Repeated fractional intradermal dosing of an inactivated polio vaccine by a single hollow microneedle leads to superior immune responses, Journal of Controlled Release 242: 141-147.
- Schipper P., Maaden K. van der, Romeijn S.G., Oomens C., Kersten G.F.A., Jiskoot W. & Bouwstra J.A. (2016), Determination of depth-dependent intradermal immunogenicity of adjuvanted inactivated polio vaccine delivered by microinjections via hollow microneedles, Pharmaceutical Research 33: 2269-2279.
- Boiten W., Absalah .S, Vreeken R, Bouwstra J. & Van Smeden J. (2016), Quantitative analysis of ceramides using a novel lipidomics approach with three dimensional response modelling, Biochimica et Biophysica Acta 1861(11): 1652-1661.
- Römgens A.M., Bader D.L., Bouwstra J.A. & Oomens C.W.J. (2016), Predicting the optimal geometry of microneedles and their array for dermal vaccination using a computational model, Computer Methods in Biomechanics and Biomedical Engineering 19(15): 1599-1609.
- Mojumdar E.H., Gooris G.S., Groen D., Barlow D.J., Lawrence M.J., Demé B. & Bouwstra J.A. (2016), Stratum corneum lipid matrix: Location of acyl ceramide and cholesterol in the unit cell of the long periodicity phase, Biochimica et Biophysica Acta 1858(8): 1926-1934.
- Römgens A.M., Bader D.L., Bouwstra J.A. & Oomens C.W. (2016), A theoretical compartment model for antigen kinetics in the skin, European Journal of Pharmaceutical Sciences 84: 18-25.
- Uchiyama M., Oguri M., Mojumdar A., Gooris G.S. & Bouwstra J.A. (2016), Free fatty acids chain length distribution affects the permeability of skin lipid model membranes, Biochimica et Biophysica Acta 1858(9): 2050-2059.
- Mojumdar E.H., Gooris G.S. & Bouwstra J.A. (2015), Phase behavior of skin lipid mixtures: the effect of cholesterol on lipid organization, Soft Matter 11(21): 4326-4336.
- Danso M.O., Drongelen V. van, Mulder A., Gooris G.S., Smeden J. van, El Ghalbzouri A. & Bouwstra J.A. (2015), Exploring the potentials of nurture: 2nd and 3rd generation explant human skin equivalents, Journal of Dermatological Science 77(2): 102-109.
- Hirschberg H.J.H.B., Riet E., Oosterhoff D., Bouwstra J.A. & Kersten G.F.A. (2015), Animal models for cutaneous vaccine delivery, European Journal of Pharmaceutical Sciences 71: 112-122.
- Monkare J.T., Nejadnik M.R., Baccouche K., Romeijn S., Jiskoot W. & Bouwstra J.A. (2015), IgG-loaded hyaluronan-based dissolving microneedles for intradermal protein delivery, 218: 53-62.
- Maaden K. van der, Luttge R., Vos P.J., Bouwstra J.A., Kersten G.F.A. & Ploemen I. (2015), Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays, Drug Delivery and Translational Research 5: 397-406.
- Gordon S., Daneshian M., Bouwstra J.A., Caloni F., Constant S., Davies D.E., Dandekar G., Guzman C.A., Fabian E., Haltner E., Hartung T., Hasiwa N., Hayden P., Kandarova H., Khare S., Krug H.F., Kneuer C., Leist M., Lian G., Marx U., Metzger M., Ott K., Prieto P., Roberts M.S., Roggen E.L., Tralau T., Braak C. van den, Walles H. & Lehr C.M. (2015), Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology, ALTEX - Alternatives to Animal Experimentation 32(4): 327-378.
- Gruber R., Börnchen C., Rose K., Daubmann A., Volksdorf T., Wladykowski E., Vidal-Y-Sy S., Peters E.M., Danso M., Bouwstra J.A., Hennies H.C., Moll I., Schmuth M. & Brandner J.M. (2015), Diverse regulation of claudin-1 and claudin-4 in atopic dermatitis, The American Journal of Pathology 185(10): 2777-89.
- Römgens A.M., Bader D.L., Bouwstra J.A., Baaijens F.P. & Oomens C.W. (2015), Diffusion profile of macromolecules within and between human skin layers for (trans)dermal drug delivery, Journal of the Mechanical Behavior of Biomedical Materials 50: 215-22.
- Maaden K. van der, Sekerdag E., Schipper P., Kersten G.F.A., Jiskoot W. & Bouwstra J.A. (2015), Layer-by-Layer Assembly of Inactivated Poliovirus and N-Trimethyl Chitosan on pH-Sensitive Microneedles for Dermal Vaccination, Langmuir 31(31): 8654-60.
- Thakoersing V.S., Smeden J. van, Boiten W.A., Gooris G.S., Mulder A.A., Vreeken R.J., El Ghalbzouri A. & Bouwstra J.A. (2015), Modulation of stratum corneum lipid composition and organization of human skin equivalents by specific medium supplements, Experimental Dermatology 24(9): 669-74.
- Drongelen V. van, Danso M.O., Out J.J., Mulder A.A., Lavrijsen A.P., Bouwstra J.A. & El Ghalbzouri A. (2015), Explant cultures of atopic dermatitis biopsies maintain their epidermal characteristics in vitro, Cell and Tissue Research 361(3): 789-97.
- Varypataki E.M., Maaden K. van der, Bouwstra J.A., Ossendorp F.A. & Jiskoot W. (2015), Cationic liposomes loaded with a synthetic long peptide and poly(I:C): a defined adjuvanted vaccine for induction of antigen-specific T cell cytotoxicity, AAPS Journal 17(1): 216-226.
- Mojumdar E.H., Gooris G.S., Barlow D.J., Lawrence M.J., Deme B. & Bouwstra J.A. (2015), Skin Lipids: Localization of Ceramide and Fatty Acid in the Unit Cell of the Long Periodicity Phase, Biophysical Journal 108(11): 2670-2679.
- Danso M.O., Berkers T., Mieremet A., Hausil F. & Bouwstra J.A. (2015), An ex vivo human skin model for studying skin barrier repair, Experimental Dermatology 24(1): 48-54.
- Van Smeden Jeroen, Janssens Michelle, Kaye Edward C.J., Caspers Peter J., Lavrijsen Adriana P., Vreeken Rob J. & Bouwstra Joke A. (2014), The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients, Experimental Dermatology 23(1): 45-52.
- Maaden K. van der, Trietsch S.J., Kraan H., Varypataki E.M., Romeijn S., Zwier R., Linden H.J. van der, Kersten G., Hankemeier T., Jiskoot W. & Bouwstra J. (2014), Novel Hollow Microneedle Technology for Depth-Controlled Microinjection-Mediated Dermal Vaccination: A Study with Polio Vaccine in Rats, 31(7): 1846-1854.
- Oguri Masashi, Gooris Gert S., Bito Kotatsu & Bouwstra Joke A. (2014), The effect of the chain length distribution of free fatty acids on the mixing properties of stratum corneum model membranes, Biochimica et Biophysica Acta (BBA) - Biomembranes 1838(7): 1851-1861.
- Smeden J. van, Boiten W.A., Hankemeier T., Rissmann R., Bouwstra J.A. & Vreeken R.J. (2014), Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841(1): 70-79.
- Mojumdar E.H., Kariman Z., Van Kerckhove L., Gooris G.S. & Bouwstra J.A. (2014), The role of ceramide chain length distribution on the barrier properties of the skin lipid membranes, Biochimica et Biophysica Acta (BBA) - Biomembranes 1838(10): 2473-2483.
- Van Smeden J., Janssens M., Gooris G.S. & Bouwstra J.A. (2014), The important role of stratum corneum lipids for the cutaneous barrier function, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841(3): 295-313.
- Romgens A.M., Bader D.L., Bouwstra J.A., Baaijens F.P.T. & Oomens C.W.J. (2014), Monitoring the penetration process of single microneedles with varying tip diameters, Journal of the Mechanical Behavior of Biomedical Materials 40: 397-405.
- Maaden Koen van der, Varypataki Eleni Maria, Yu Huixin, Romeijn Stefan, Jiskoot Wim & Bouwstra Joke (2014), Parameter optimization toward optimal microneedle-based dermal vaccination, 64: 18-25.
- Maaden K. van der, Varypataki E.M., Romeijn S.G., Ossendorp F.A., Jiskoot W. & Bouwstra J.A. (2014), Ovalbumin-coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice, European Journal of Pharmaceutics and Biopharmaceutics 88(2): 310-315.
- Janssens M., Van Smeden J., Puppels G.J., Lavrijsen A.P.M., Caspers P.J. & Bouwstra J.A. (2014), Lipid to protein ratio plays an important role in the skin barrier function in patients with atopic eczema, British Journal of Dermatology 170(6): 1248-1255.
- Groen Daniel, Berthaud Fabienne, Bouwstra Joke A., Chapuis Christian, Gooris Gert S. & Boncheva Mila (2014), In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids, Biochimica et Biophysica Acta (BBA) - Biomembranes 1838(1): 310-318.
- Maaden Koen van der, Tomar Jasmine, Jiskoot Wim & Bouwstra Joke (2014), Chemical Modifications of Silicon Surfaces for the Generation of a Tunable Surface Isoelectric Point, Langmuir 30(7): 1812-1819.
- Mojumdar Enamul H., Helder Richard W.J., Gooris Gert S. & Bouwstra Joke A. (2014), Monounsaturated Fatty Acids Reduce the Barrier of Stratum Corneum Lipid Membranes by Enhancing the Formation of a Hexagonal Lateral Packing, Langmuir 30(22): 6534-6543.
- Van Drongelen Vincent, Danso Mogbekeloluwa O., Mulder Aat, Mieremet Arnout, Van Smeden Jeroen, Bouwstra Joke A. & El Ghalbzouri Abdoelwaheb (2014), Barrier Properties of an N/TERT-Based Human Skin Equivalent, Tissue Engineering Part B: Reviews 20(21-22): 3041-3049.
- Van Smeden Jeroen, Janssens Michelle, Boiten Walter A., Van Drongelen Vincent, Furio Laetitia, Vreeken Rob J., Hovnanian Alain & Bouwstra Joke A. (2014), Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients, 134(5): 1238-1245.
- Maaden Koen van der, Sekerdag Emine, Jiskoot Wim & Bouwstra Joke (2014), Impact-Insertion Applicator Improves Reliability of Skin Penetration by Solid Microneedle Arrays, AAPS Journal 16(4): 681-684.
- Danso Mogbekeloluwa O., Van Drongelen Vincent, Mulder Aat, Van Esch Jeltje, Scott Hannah, Van Smeden Jeroen, El Ghalbzouri Abdoelwaheb & Bouwstra Joke A. (2014), TNF-alpha and Th2 Cytokines Induce Atopic Dermatitis-Like Features on Epidermal Differentiation Proteins and Stratum Corneum Lipids in Human Skin Equivalents, 134(7): 1941-1950.
- Uchino Tomonobu, Lefeber Fons, Gooris Gert & Bouwstra Joke (2014), Characterization and skin permeation of ketoprofen-loaded vesicular systems, European Journal of Pharmaceutics and Biopharmaceutics 86(2): 156-166.
- Janssens M., Mulder A.A., Van Smeden J., Pilgram G.S.K., Wolterbeek R., Lavrijsen A.P.M., Koning R.I., Koster A.J. & Bouwstra J.A. (2013), Electron diffraction study of lipids in non-lesional stratum corneum of atopic eczema patients, Biochimica et Biophysica Acta (BBA) - Biomembranes 1828(8): 1814-1821.
- Van Smeden Jeroen, Janssens Michelle, Lavrijsen Adriana P., Kezic Sanja, Vreeken Rob J. & Bouwstra Joke A. (2013), Skin barrier dysfunction in non-lesional atopic eczema: the role of stratum corneum lipids, European Journal of Dermatology 23: 39-42.
- Basse Line Hollesen, Groen Daniel & Bouwstra Joke A. (2013), Permeability and lipid organization of a novel psoriasis stratum corneum substitute, 457(1): 275-282.
- Mojumdar E.H., Groen D., Gooris G.S., Barlow D.J., Lawrence M.J., Deme B. & Bouwstra J.A. (2013), Localization of Cholesterol and Fatty Acid in a Model Lipid Membrane: A Neutron Diffraction Approach, Biophysical Journal 105(4): 911-918.
- Skolova Barbora, Janusova Barbora, Zbytovska Jarmila, Gooris Gert, Bouwstra Joke, Slepicka Petr, Berka Pavel, Roh Jaroslav, Palat Karel, Hrabalek Alexandr & Vavrova Katerina (2013), Ceramides in the Skin Lipid Membranes: Length Matters, Langmuir 29(50): 15624-15633.
- Bjorklund S., Nowacka A., Bouwstra J.A., Sparr E. & Topgaard D. (2013), Characterization of stratum corneum molecular dynamics by natural-abundance 13C solid-state NMR, PLoS ONE 8(4): e61889.
- Kuntsche Judith & Bouwstra Joke (2013), Editorial to the special EJPS issue "(Trans)dermal drug delivery: Emerging trends to study and overcome the skin barrier", European Journal of Pharmaceutical Sciences 50(5): 545-545.
- Windbergs M., Hansen S., Schroeter A., Schaefer U.F., Lehr C.-M. & Bouwstra J. (2013), From the Structure of the Skin Barrier and Dermal Formulations to in vitro Transport Models for Skin Absorption: Skin Research in the Netherlands and in Germany, 26(4-6): 317-330.
- Maaden K. van der, Yu H., Sliedregt K., Zwier R., Leboux R., Oguri M., Kros A., Jiskoot W. & Bouwstra J.A. (2013), Nanolayered chemical modification of silicon surfaces with ionizable surface groups for pH-triggered protein adsorption and release: application to microneedles, Journal of Materials Chemistry B 1(35): 4466-4477.
- Van Drongelen Vincent, Alloul-Ramdhani Mariam, Danso Mogbekeloluwa O., Mieremet Arnout, Mulder Aat, Van Smeden Jeroen, Bouwstra Joke A. & El Ghalbzouri Abdoelwaheb (2013), Knock-down of filaggrin does not affect lipid organization and composition in stratum corneum of reconstructed human skin equivalents, Experimental Dermatology 22(12): 807-812.
- Thakoersing Varsha S., Van Smeden Jeroen, Mulder Aat A., Vreeken Rob J., El Ghalbzouri Abdoelwaheb & Bouwstra Joke A. (2013), Increased Presence of Monounsaturated Fatty Acids in the Stratum Corneum of Human Skin Equivalents, 133(1): 59-67.
- Van Smeden J., Hoppel L., Van der Heijden R., Hankemeier T., Vreeken R.J. & Bouwstra J.A. (2012), LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery, 52(6): .
- Janssens M., Van Smeden J., Gooris G.S., Bras W., Portale G., Caspers P.J., Vreeken R.J., Kezic S., Lavrijsen A.P. & Bouwstra J.A. (2012), Lamellar lipid organization and ceramide composition in the stratum corneum of patients with atopic eczema, 131(10): .
- Thakoersing V.S., Gooris G.S., Mulder A., Rietveld M., El Ghalbzouri A. & Bouwstra J.A. (2012), Unraveling Barrier Properties of Three Different In-House Human Skin Equivalents, Tissue Engineering Part C: Methods 18(1): 1-11.
- Amorij J.P., Kersten G.F.A., Saluja V., Tonnis W.F., Hinrichs W.L.J., Slutter B., Bal S.M., Bouwstra J.A., Huckriede A. & Jiskoot W. (2012), Towards tailored vaccine delivery: Needs, challenges and perspectives, 161(2): 363-376.
- Bouwstra J.A., Nahmoed N., Groenink H.W.W. & Ponec M. (2012), Human skin equivalents are an excellent tool to study the effect of moisturizers on the water distribution in the stratum corneum, International Journal of Cosmetic Science 34(6): 560-566.
- Thakoersing V.S., Danso M.O., Mulder A., Gooris G.S., El Ghalbzouri A. & Bouwstra J.A. (2012), Nature versus nurture: does human skin maintain its stratum corneum lipid properties in vitro?, Experimental Dermatology 21(11): 865-870.
- Janssens M., Smeden J. van, Gooris G.S., Bras W., Portale G., Caspers P.J., Vreeken R.J., Hankemeier T., Kezic S., Wolterbeek R., Lavrijsen A.P. & Bouwstra J.A. (2012), Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients, Journal of Lipid Research 53(12): 2755-2766.
- Maaden K. van der, Sliedregt K., Kros A., Jiskoot W. & Bouwstra J. (2012), Fluorescent Nanoparticle Adhesion Assay: a Novel Method for Surface pK(a) Determination of Self-Assembled Monolayers on Silicon Surfaces, Langmuir 28(7): 3403-3411.
- Mojumdar E.H., Groen D., Gooris G.S., Barlow D.J., Lawrence M.J., Deme B. & Bouwstra J.A. (2012), Localization of cholesterol in the model lipid membrane: a neutron diffraction approach, International Journal of Cosmetic Science 34(4): 375-375.
- Gooris G.S. & Bouwstra J.A. (2012), The interaction of unsaturated fatty acids with stratum corneum lipids, International Journal of Cosmetic Science 34(4): 369-369.
- Hirschberg H., Kuijk S. van, Loch J., Jiskoot W., Bouwstra J., Kersten G. & Amorij J.P. (2012), A combined approach of vesicle formulations and microneedle arrays for transcutaneous immunization against hepatitis B virus, European Journal of Pharmaceutical Sciences 46(1-2): 1-7.
- Maaden K. van der, Jiskoot W. & Bouwstra J.A. (2012), Microneedle technologies for (trans)dermal drug and vaccine delivery, Journal of Controlled Release 161(2): 645-655.
- Groen D., Gooris G.S., Barlow D.J., Lawrence M.J., Van Mechelen J.B., Deme B. & Bouwstra J.A. (2011), Disposition of ceramide in model lipid membranes determined by neutron diffraction, Biophysical Journal 100(6): .
- Thakoersing V.S., Gooris G.S., Mulder A., Rietveld M., El Ghalbzouri A. & Bouwstra J.A. (2011), Unraveling Barrier Properties of Three Different In-House Human Skin Equivalents, Tissue Engineering Part C: Methods : .
- Slutter B., Bal S.M., Ding Z., Jiskoot W. & Bouwstra J.A. (2011), Adjuvant effect of cationic liposomes and CpG depends on administration route, JOURNAL OF CONTROLLED RELEASE 154(2): .
- Carstens M.G., Camps MG, Henriksen-Lacey M., Franken K., Ottenhoff T.H., Perrie Y., Bouwstra J.A., Ossendorp F. & Jiskoot W. (2011), Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines, Vaccine 29(29-30): .
- Bal S.M., Slutter B., Jiskoot W. & Bouwstra J.A. (2011), Small is beautiful: N-trimethyl chitosan-ovalbumin conjugates for microneedle-based transcutaneous immunisation, Vaccine 29(23): .
- Carstens M.G., Maaden K. van der, Velden D. van der, Ottenhoff T.H., Melief C.J., Ossendorp F., Bouwstra J.A. & Jiskoot W. (2011), Evaluation of the high-pressure extrusion technique as a method for sizing plasmid DNA-containing cationic liposomes, Journal of Liposome Research 21(4): 286-295.
- Verheul R.J., Slutter B., Bal S.M., Bouwstra J.A., Jiskoot W. & Hennink W.E. (2011), Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination, JOURNAL OF CONTROLLED RELEASE 156(1): .
- Ackaert O.W., De Graan J., Shi S., Vreeken R., Della Pasqua O.E., Dijkstra D., Westerink B.H., Danhof M. & Bouwstra J.A. (2011), The Pharmacokinetics and Pharmacological Effect of (S)-5-OH-DPAT Following Controlled Delivery with Transdermal Iontophoresis, JOURNAL OF PHARMACEUTICAL SCIENCES 100(7): .
- Groen D., Poole D.S., Gooris G.S. & Bouwstra J.A. (2011), Investigating the barrier function of skin lipid models with varying compositions, European Journal of Pharmaceutics and Biopharmaceutics 79(2): .
- Bal S.M., Slutter B., Verheul R., Bouwstra J.A. & Jiskoot W. (2011), Adjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: Adjuvant- and site-dependent immunogenicity in mice, European Journal of Pharmaceutical Sciences : .
- Smijs G.M.T. & Bouwstra J.A. (2010), Focus on Skin as a Possible Port of Entry for Solid Nanoparticles and the Toxicological Impact, Journal of Biomedical Nanotechnology 6(5): 469-484.
- Thakoersing V.S., Ponec M. & Bouwstra J.A. (2010), Generation of Human Skin Equivalents Under Submerged Conditions-Mimicking the In Utero Environment, Tissue Engineering Part A 16(4): 1433-1441.
- Bal S., Kruithof A.C., Liebl H., Tomerius M., Bouwstra J.A., Lademann J. & Meinke M. (2010), In vivo visualization of microneedle conduits in human skin using laser scanning microscopy, Laser Physics Letters 7(3): 242-246.
- Caussin J., Gooris G.S., Janssens M. & Bouwstra J.A. (2008), Lipid organization in human and porcine stratum corneum differs widely, while lipid mixtures with porcine ceramides model human stratum corneum lipid organisation very closely, Biochimica et Biophysica Acta - Biomembranes 1778: 1472-1482.
- Rissmann R., Groenink H.W.W., Gooris G.S., Oudshoorn M.H.M., Hennink W.E., Ponec M.P. & Bouwstra J.A. (2008), Temperature-induced changes in structural and physicochemical properties of vernix caseosa, 128: 292-299.
- Bouwstra J.A., Groenink H.W.W., Kempenaar J.A., Romeijn S.G. & Ponec M.P. (2008), The water distribution and natural moisturizer factor in human skin equivalents grown at various relative humidities, 128: 378-388.
- Verbaan F.J., Bal S.M., Berg D.J. van den, Dijksman J.A., Hecke M.L. van, Verpoorten H., Berg A. van den, Luttge R. & Bouwstra J.A. (2008), Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method, Journal of Controlled Release 128(1): 80-88.
- Bal S.M., Caussin J., Pavel S. & Bouwstra J.A. (2008), In vivo assessment of safety of microneedle arrays in human skin, European Journal of Pharmaceutical Sciences 35: 193-202.
- Rissman R., Oudshoorn M.H.M., Kocks E., Hennink W.E., Ponec M. & Bouwstra J.A. (2008), Lanolin-derived lipid mixtures mimic closely the lipid composition and organization of vernix caseosa lipids, Biochimica et Biophysica Acta 1778: 2350-2360.
- Ding Z., Bivas-Benita M., Hirschberg H., Kersten G.F.A., Jiskoot W. & Bouwstra J.A. (2008), Preparation and characterization of diphtheria toxoid-loaded elastic vesicles for transcutaneous immunization, Journal of Drug Targeting 16: 555-563.
- Groen D., Gooris G.S., Ponec M. & Bouwstra J.A. (2008), Two new methods for preparing a unique stratum corneum substitute, Biochimica et Biophysica Acta - Biomembranes 1778: 2421-2429.
- Bouwstra J.A., Gooris G.S. & Ponec M. (2008), Skin lipid organization, composition and barrier function, International Journal of Cosmetic Science 30(5): 388.
- Smijs T.G., Mulder A.A., Pavel S., Onderwater J.J.M., Koerten H.K. & Bouwstra J.A. (2008), Morphological changes of the dermatophyte Trichophyton rubrum after photodynamic treatment: a scanning electron microscopy study, Med. Mycology 46(4): 315-325.
- Honeywell-Nguyen P.L. & Bouwstra J.A. (2008), Vesicles as skin delivery vehicles. In: Wiechers J.W. (red.), Science and applications of skin delivery systems. Carol Stream, USA: Allured Publishing Corporation. 205-266.
- Grams Y.Y., Wiechers J.M. & Bouwstra J.A. (2008), Novel ways of measuring the transfollicular transport of active ingredients across the skin. In: Wiechers J.W. (red.), Science and applications of skin delivery systems. Carol Stream, USA: Allured Publishing Corporation. 425-440.
- Roberts M.S., Bouwstra J.A., Pirot F. & Falson F. (2008), Skin hydration – A key determinant in topical absorption. In: Walters H.A. & Roberts M.S. (red.), Dermatologic, cosmeceutic and cosmetic development: therapeutic and novel approaches. New York: Informa Healthcare USA, Inc.. 115-128.
- Bouwstra J.A. (2008), The lipid organisation of the skin barrier. In: Rawlings A.V. & Leyden J.J. (red.), Skin Moisturization, Second edition. New York: Informa Healthcare.
- Oudshoorn M.H.M., Rissman R., Coelen D. van der, Hennink W.E., Ponec M. & Bouwstra J.A. (2008), Development of a murine model to evaluate the effect of vernix caseosa on skin barrier recovery, Experimental Dermatology : .
- Rissmann R., Gooris G.S., Ponec M. & Bouwstra J.A. (2008), Long periodicity phase in extracted lipids of vernix caseosa obtained with equilibration at physiological temperature, Chemistry and Physics of Lipids : .
- Caussin J., Gooris G.S. & Bouwstra J.A. (2008), FTIR studies show lipophilic moisturizers to interact with stratum corneum lipids, rendering the more densely packed, Biochimica et Biophysica Acta - Biomembranes 1778: 1517-1524.
- Verbaan F.J., Bal S.M., Berg D.J. van den, Groenink H.W.M., Verpoorten H., Lüttge R. & Bouwstra J.A. (2007), Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin, JOURNAL OF CONTROLLED RELEASE 117: 238-245.
- Gooris G.S. & Bouwstra J.A. (2007), Infrared spectroscopic study of stratum corneum model membranes prepared from human ceramides, cholesterol and fatty acids, Biophysical Journal 92(8): 2785-2795.
- Smijs T.G., Bouwstra J.A., Schuitmaker H.J., Talebi M. & Pavel S. (2007), A Novel ex-vivo skin model to study the susceptibility of the dermatophyte Trichophyton rubrum to photodynamic treatment in different growth phases, Journal of Antimicrobial Chemotherapy 59: 433-440.
- Caussin J., Groenink W., Graaff A. de, Gooris G.S., Wiechers J.M., Aelst A.C. van & Bouwstra J.A. (2007), Lipophilic and hydrophilic moisturizers show different actions on human skin as revealed by cryo scanning electron microscopy, Experimental Dermatology 16: 891-898.
- Jager M.W. de, Ponec M.P. & Bouwstra J.A. (2007), The lipid organization in stratum corneum and model systems based on ceramides. In: Touitou E. & Barry B.W. (red.), Enhancement in Drug Delivery. New York: Taylor & Francis Group. 217-232.
- Caussin J., Gooris G.S., Groenink H.W.M., Wiechers J.M. & Bouwstra J.A. (2007), Interaction of lipophilic moisturisers on stratum corneum lipid domains in vitro and in vivo, 20: 175-186.
- Smijs T.G., Bouwstra J.A., Talebi M. & Pavel S. (2007), Investigation of conditions involved in the susceptibility of the dermatophyte Trichophyton rubrum to photodynamic treatment, Journal of Antimicrobial Chemotherapy 60: 750-769.
- Oudshoorn M.H., Penterman R., Rissmann R., Bouwstra J.A., Broer D.J. & Hennink W.E. (2007), Preparation and characterization of structured hydrogel microparticles based on cross-linked hyperbranched polyglycerol, Langmuir 23(23): 11819-25.
- Gooris G.S. & Bouwstra J.A. (2006), Infrared spectroscopic study of stratum corneum model membranes prepared fromhuman ceramides, cholesterol and fatty acids, Biophysical Journal : .
- Honeywell-Nguyen P.L., Groenink H.W.M. & Bouwstra J.A. (2006), Elastic vesicles as a tool for dermal and transdermal delivery, Journal of Liposome Research 16: 273-280.
- Jager M. de, Groenink H.W.M., Spek J. van der, Janmaat C., Gooris G.S., Ponec M. & Bouwstra J.A. (2006), Preparation and characterization of stratum corneum substitutes for in vitro percutaneous penetration studies, Biochimica et Biophysica Acta - Biomembranes 1758: 636-644.
- Jager M. de, Groenink H.W.M., Bielsa I., Guivernau R., Andersson E., Angelova N.S., Ponec M. & Bouwstra J.A. (2006), A Novel in vitro percutaneous penetration Model: evaluation of barrier properties with p-aminobenzoic acid and two of its derivatives, PHARMACEUTICAL RESEARCH 23: 951-960.
- Nugroho A.K., Romeijn S.G., Zwier R., Vries J.B. de, Dijkstra D., Wikström H., Pasqua O.D., Danhof M. & Bouwstra J.A. (2006), Pharmacokinetics and pharmacodynamics analysis of transdermal iontophoresis of 5-OH-DPAT in rats: in vitro - in vivo correlation, JOURNAL OF PHARMACEUTICAL SCIENCES 95: 1570-1585.
- Bouwstra J.A., Pilgram G.S.K. & Ponec M. (2006), Structure of the skin barrier. In: , Skin Barrier: Taylor & Francis Group.
- Bouwstra J.A. & Honeywell-Nguyen P.L. (2006), Vesicles as a tool for dermal and transdermal delivery. In: , Microencapsulation: Taylor & Francis Group.
- Bouwstra J.A. & Ponec M. (2006), The skin barrier in healthy and diseased state, Biochimica et Biophysica Acta - Biomembranes 1758: 2080-2095.
- Fatouros D.G., Groenink H.W.M., Graaff AM de, Aelst A.C. van, Koerten H.K. & Bouwstra J.A. (2006), Visualization studies of human skin in vitro/in vivo under the influence of an electrical field, European Journal of Pharmaceutical Sciences 29: 160-170.
- Smijs T.G., Bouwstra J.A., Schuitmaker H., Talebi M. & Pavel S. (2006), Ex vivo model for photodynamic treatment of Tricophyton rubrum, Journal of Antimicrobial Chemotherapy : .
- Rissmann R., Groenink H.W.M., Weerheim A.M., Hoath S.B., Ponec M. & Bouwstra J.A. (2006), New insights into ultrastructure, lipid composition and organization of vernix caseosa, 126: 1823-1833.
- Oudshoorn M.H., Rissmann R., Bouwstra J.A. & Hennink W.E. (2006), Synthesis and characterization of hyperbranched polyglycerol hydrogels, Biomaterials 27: 5471-5479.
- Nugroho A.K., Li L., Dijkstra D., Wikstrom H., Danhof M. & Bouwstra J.A. (2005), Transdermal iontophoresis of the dopamine agonist 5-OH-DPAT in human skin in vitro. J Control Release, JOURNAL OF CONTROLLED RELEASE 21(2): 393-403.
- Grams Y.Y., Whitehead L., Lamers G., Stuurman N. & Bouwstra J.A. (2005), On-line diffusion profile of a lipophilic model dye in different depth of a hair follicle in human scalp skin, Journal of Investigative Dermatology 125(4): 775-782.
- Jager M.J.W.M., Gooris G.S., Ponec M. & Bouwstra J.A. (2005), Lipid mixtures prepared with well-defined synthetic ceramides closely mimic the unique stratum corneum lipid phase behavior, 46(12): 2649-2656.
- Li G.L., Vries J.J. de, Steeg T.J. van, Bussche H. van den, Maas H.J., Reeuwijk H.J.E.M., Danhof M., Bouwstra J.A. & Laar T. van (2005), Transdermal iontophoretic delivery of apomorphine in patient¿s improved by surfactant formulation pretreatment, JOURNAL OF CONTROLLED RELEASE 101: 199-208.
- Nugroho A.K., Li L., Dijkstra D., Wikstrom H., Danhof M. & Bouwstra J.A. (2005), Transdermal iontophoresis of the dopamine agonist 5-OH-DPAT in human skin in vitro, JOURNAL OF CONTROLLED RELEASE 103(2): 393-403.
- Nugroho A.K., Danhof M., Bouwstra J.A. & Della Pasqua O.E. (2005), Compartmental modeling of transdermal iontophoretic transport II: in vivo model derivation and application, PHARMACEUTICAL RESEARCH 22(3): 335-346.
- Honeywell-Nguyen P.L. & Bouwstra J.A. (2005), Vesicles as a tool for transdermal and dermal delivery, Drug Discovery Today 2: 67-74.
- Li G.L., Steeg T.J. van, Putter H., Spek J. van der, Pavel S., Danhof M. & Bouwstra J.A. (2005), Cutaneous side-effects of transdermal iontophotresis with and without surfactant pretreatment: a single-blinded, randomized controlled trial, British Journal of Dermatology 153: 404-412.
- Li G.L., Steeg T.J. van, Putter H., Spek J. van der, Pavel S., Danhof M. & Bouwstra J.A. (2005), Cutaneous side-effects of transdermal iontophoresis with and without surfactant pretreatment: a single-blinded, randomized controlled trial, British Journal of Dermatology 153(2): 404-412.
- Fatouros D.G. & Bouwstra J.A. (2004), Iontophoretic enhancement of timolol across human dermatomed skin in vitro, Journal of Drug Targeting 12: 19-24.
- Nugroho A.K., Pasqua O.D., Danhof M. & Bouwstra J.A. (2004), Compartmental modeling of transdermal iotophoretic transport: I. In vitro Model derivation and application, Pharmacological Research 21: 1974-1984.
- Pilgram G.S.K. & Bouwstra J.A. (2004), Stratum corneum lipid organization in vitro and in vivo as assessed by diffraction methods. In: Forslind B., Lindberg M. & Norlen L. (red.), Skin, hair and nails: Structure and function. New York: Marcel Dekker.
- Li G.L., Vries J.J. de, Steeg T.J. van, Bussche H. van den, Maas H.J., Reeuwijk H.J.E.M., Danhof M., Bouwstra J.A. & Laar T. van (2004), Transdermal iontophoretic delivery of apomorphine in patients inproved by sufactant formulation pretreatment, JOURNAL OF CONTROLLED RELEASE 101: 199-208.
- Honeywell-Nguyen P.L., Gooris G.S. & Bouwstra J.A. (2004), Quantitative Assessment of the Transport of Elastic and Rigid Vesicle Components and a Model Drug from these Vesicle Formulations into Human Skin In Vivo, 123: 902-910.
- Nugroho A.K., Li G.L., Danhof M. & Bouwstra J.A. (2004), Transdermal iontophoresis of rotigotine across human stratum corneum in vitro: influence of pH and NaCI concentration, PHARMACEUTICAL RESEARCH 21: 844-850.
- Grams Y.Y., Whitehead L., Cornwell P. & Bouwstra J.A. (2004), On-line visualization of dye diffusion in fresh unfixed human skin, PHARMACEUTICAL RESEARCH 21: 851-859.
- Jager M. de, Gooris G.S., Dolbnya I.P., Bras W., Ponec-Waelsch M.H. & Bouwstra J.A. (2004), Novel lipid mixtures based on synthetic ceramides reproduce the unique stratum corneum lipid organization, 45: 923-932.
- Jager M. de, Gooris G.S., Ponec-Waelsch M.H. & Bouwstra J.A. (2004), Acylceramide head grouparchitecture affects lipid organization in synthetic ceramide mixtures, Journal of Investigative Dermatology 123(5): 911-916.
- Grams Y.Y., Whitehead L., Cornwell P. & Bouwstra J.A. (2004), Time and depth resolved visualization of the diffusion of a lipophilic dye into the hair follicle of fresh unfixed human scalp skin, JOURNAL OF CONTROLLED RELEASE 98: 367-378.
- Fatouros D.G. & Bouwstra J.A. (2004), Transdermal iontophoresis of timolol across human stratum corneum: effect of temperature and vehicle formulation, Journal of Drug De Sci. Tech. : .
- Jager M.W. de, Gooris G.S., Dolbnya I.P., Ponec M.P. & Bouwstra J.A. (2004), Modelling the stratum corneum lipid organisation with synthetic lipid mixtures: the importance of synthetic ceramide composition, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 30: 132-140.
- Li G.L., Danhof M., Frederik P.M. & Bouwstra J.A. (2003), Pretreatment of water-based surfactant affects transdermal iontophoretic delivery of R-apomorphine in vitro, PHARMACEUTICAL RESEARCH 20: 653-659.
- Honeywell-Nguyen P.L., Arenja S. & Bouwstra J.A. (2003), Skin penetration and mechanisms of action in the delivery of the D2-agonist rotigotine from surfactant-based elastic vesicle formulations, PHARMACEUTICAL RESEARCH 20: 1619-1625.
- Li G., Danhof M., Frederik P.M. & Bouwstra J.A. (2003), Pretreatment with a water-based surfactant formulation affects transdermal iontophoretic delivery of R-apomorphine in vitro, PHARMACEUTICAL RESEARCH 20(4): 653-659.
- Li G.L., Grossklaus A., Danhof M. & Bouwstra J.A. (2003), Iontophoric R-apomorphine delivery in combination with surfactant pretreatment: in vitro validation studies, 266: 61-68.
- Bouwstra J.A., Graaff A. de, Gooris G.S., Nijsse J., Wiechers J.M. & Aelst A.C. van (2003), Water distribution and related morphology in human stratum corneum at different, 120: 750-758.
- Jager M.J., Gooris G.S., Dolbny I.P., Bras W., Ponec-Waelsch M.H. & Bouwstra J.A. (2003), Important role of the equilibration temperature and fatty acid content on the phase behaviour of lipid mixtures based on synthetic ceramides, Chemistry and Physics of Lipids 124: 123-134.
- Bouwstra J.A., Honeywell-Nguyen P.L., Gooris G.S. & Ponec M. (2003), Structure of the skin barrier and its modulation by vesicular formulations, Progress in Lipid Research 42: 1-36.
- Jager M.W. de, Gooris G.S., Dolbnya I.P., Bras W., Ponec M.P. & Bouwstra J.A. (2003), The phase behaviour of skin lipid mixtures based on synthetic ceramides, Chemistry and Physics of Lipids 124: 123-134.
- Grams Y.Y., Alaruikka S., Lashley L., Caussin J., Whitehead L. & Bouwstra J.A. (2003), Permeant lipophilicity and vehicle composition influences accumulation of dyes in hair follicles of human skin, European Journal of Pharmaceutical Sciences 18: 329-336.
- Honeywell-Nguyen P.L., Groenink H.W.M., Graaff AM de & Bouwstra J.A. (2003), The in vivo transport of elastic vesicles into human skin: effects of occlusion, volume and duration of application, JOURNAL OF CONTROLLED RELEASE 90: 243-255.
- Honeywell-Nguyen P.L. & Bouwstra J.A. (2003), A novel mechanism of action for the transdermal delivery of pergolide from surfactant-based elastic vesicles, JOURNAL OF CONTROLLED RELEASE 86: 145-156.
- Graaff AM de, Li G.L., Aelst A.C. van & Bouwstra J.A. (2003), Combined chemical and electrical enhancement modulates stratum corneum structure, JOURNAL OF CONTROLLED RELEASE 90: 49-58.
- Li G.L., Geest R. van der, Chanet L., Zanten E. van, Danhof M. & Bouwstra J.A. (2002), In itro iontophoresis of R-apomorphine across human stratum corneum. Structure-transport relationship of penetration enhancement, JOURNAL OF CONTROLLED RELEASE 84: 49-57.
- Grams Y.Y. & Bouwstra J.A. (2002), A new method to determine the distribution of a fluorophore in scalp skin with focus on hair follicles, PHARMACEUTICAL RESEARCH 19: 350-354.
- Bouwstra J.A. & Honeywell-Nguyen P.L. (2002), Skin structure and mode of action of vesicles, Advanced Drug Delivery Reviews 54(1): S41-S55.
- Bouwstra J.A., Gooris G.S. & Ponec M.P. (2002), The lipid organisation of the skin barrier: liquid and crystalline domains coexist in lamellar phases, Journal of Biological Physics 28: 211-223.
- Bouwstra J.A., Pilgram G.S.K. & Ponec M.P. (2002), the single gel phase exist in stratum corneum?, 118: 897-901.
- Bouwstra J.A., Graaff A. de, Groenink W. & Honeywell L. (2002), Elastic vesciles: interaction with human skin and drug transport, Cell. Mol. Biol. Lett. 7: 222-223.
- Grams Y.Y. & Bouwstra J.A. (2002), Penetration and distribution of three lipophilic probes in vitro in human skin focusing on the hair follicle, JOURNAL OF CONTROLLED RELEASE 83: 253-262.
- Bouwstra J.A. & Honeywell-Nguyen P.L. (2002), Skin structure and mode of action of vesicles, Crit. Rev. Ther. Syst. 54: S42-S53.
- Honeywell-Nguyen P.L., Bussche M.H. van den, Junginger H.E. & Bouwstra J.A. (2002), The effect of surfactant-based elastic and rigid vesicles on the penetration of lidocaine across human skin, STP PHARMA SCIENCES 12: 257-262.
- Honeywell-Nguyen P.L., Graaff AM de, Groenink H.W.M. & Bouwstra J.A. (2002), The in vivo and in vitro interactions of elastic and rigid vesicles with human skin, Biochimica et Biophysica Acta 1573: 130-140.
- Li G.L., Geest R. van der, Chanet L., Zanten E. van, Danhof M. & Bouwstra J.A. (2002), In vitro iontophoresis of R-apomorphine across human stratum corneum. Structure-transport relationship of penetration enhancement, JOURNAL OF CONTROLLED RELEASE 7: 49-57.
- Honeywell-Nguyen P.L., Frederik P.M., Bomans P., Junginger H.E. & Bouwstra J.A. (2002), Transdermal delivery of pergolide from surfactant-based elastic and rigid vesicles: characterization and in vitro transport studies, PHARMACEUTICAL RESEARCH 19: 991-997.
- Pechtold L.A., Bodde H.E., Junginger H.E., Koerten H.K. & Bouwstra J.A. (2001), X-ray microanalysis of cryopreserved human skin to study the effect of iontophoresis on percutaneous ion transport, PHARMACEUTICAL RESEARCH 18: 1012-1017.
- Ponec-Waelsch M.H., Pilgram G.S.K., Boelsma E., Koerten H.K., Bouwstra J.A., Mommaas-Kienhuis A.M. & Gibbs S. (2001), Barrier function in reconstructed epidermis and its resemblance to native human skin, Skin Pharmacology and applied Skin Physiology 14(1 (suppl)): 63-71.
- Pilgram G.S.K., Vissers C.J., Meulen J. van der, Pavel S., Lavrijsen A.P.M., Bouwstra J.A. & Koerten H.K. (2001), Aberrant Lipid Organization in Stratum Corneum of Patients with Atopic Dermatitis and Lamellar Ichthyosis, 117: 710-717.
- Pilgram G.S.K., Gooris G.S., Koerten H.K. & Bouwstra J.A. (2001), The influence of two azones and sebaceous lipids on the lateral organization of lipids isolated from human stratum corneum, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1511: 244-254.
- Bouwstra J., Pilgram G.S.K., Gooris G.S., Koerten H. & Ponec M. (2001), New aspects of the skin barrier organization, Skin Pharmacology and applied Skin Physiology 14(1): 52-62.
- Ponec-Waelsch M.H., Boelsma E., Weerheim A., Mulder A., Bouwstra J.A. & Mommaas-Kienhuis A.M. (2000), Lipid and iltrastructural characterization of reconstructed skin models, 203: 211-225.
- Pilgram G.S.K., Vissers D., Meulen J. van der, Bouwstra J.A. & Koerten H.K. (2000), The lateral lipid organization in diseased skin in relation to barrier function, 115: 923.
- Pilgram G.S.K., Engelsma A.M., Ponec-Waelsch M.H., Bouwstra J.A. & Koerten H.K. (2000), The application of (cryo-) electron diffraction to study the lateral organization of human stratum corneum lipids: An overview, Research Advances in Lipids 1: 119-131.
- Pilgram G.S.K., Engelsma A.M., Gibbs S., Ponec-Waelsch M.H., Bouwstra J.A. & Koerten H.K. (2000), Electron diffraction study of the lipid organization in human and cultured stratum corneum, Biophysical Journal 78: 489A.
- Pilgram G.S.K., Engelsma A.M., Koerten H.K. & Bouwstra J.A. (2000), The effect of two azones on the lateral lipid organization of human stratum corneum and its permeability, PHARMACEUTICAL RESEARCH 17: 796-802.
- Pilgram G.S.K., Engelsma A.M., Koerten H.K. & Bouwstra J.A. (2000), Studie naar de laterale organisatie van geïsoleerde humane stratum corneum lipiden, 10: 73.
- Pilgram G.S.K., Engelsma-Pelt A.M. van, Koerten H.K. & Bouwstra J.A. (1999), Study on permeability of human stratum corneum lipid organization to mercury-chloride in relation to penetration enhancers. [overig].
- Bouwstra J.A. (1999), Vesicles as tool for dermal and transdermal drug delivery in Pharmaceuti-cal Emulsions and Suspensisons. In: Mestres G. (red.), Vesicles as tool for dermal and transdermal drug delivery in Pharmaceuti-cal Emulsions and Suspensisons.
- Pilgram G.S.K., Engelsma-Pelt A.M. van, Koerten H.K. & Bouwstra J.A. (1999), Effect of penetration enhancers on human stratum corneum lipid organization studies by electron diffraction. [overig].
- Pilgram G.S.K., Engelsma-Van Pelt A.M., Koerten H.K. & Bouwstra J.A. (1999), The lipid organization and the penetration of mercury studied as a function of depth in human stratum corneum, NWO-werkgemeenschap Huid : .
- Suhonen M., Bouwstra J.A. & Urtti A. (1999), Enhancement of percutaneous absorption in relation to stratum corneum structural alterations, JOURNAL OF CONTROLLED RELEASE : .
- Pilgram G.S.K., Engelsma-Pelt A.M. van, Bouwstra J.A. & Koerten H.K. (1999), Electron diffraction provides new information on human stratum lipid organization in relation to depth and temperature, 113: 403-409.
- Tanojo H., Bouwstra J.A. & Junginger H.E. (1999), Thermal analysis studies on human skin and skin barrier modulation by fatty acids and propylene glycol, Journal of Thermal Analysis : .
- Jadoul A., Bouwstra J.A. & Preat V. (1999), Effect of iontophoresis and electroporation on the stratum corneum. Review of biophysical studies, Advanced Drug Delivery Reviews : .
- Pilgram G.S.K., Engelsma-Pelt A.M. van, Gibbs S., Ponec M., Bouwstra J.A. & Koerten H.K. (1999), Diffraction study of the lipid organization in relation to depth in human and cultured stratum corneum, 113: 700-700.
- Bouwstra J.A. (1998), X-ray diffraction, an excellent tool in studying the lipid organisation in membranes. In: Graig D. (red.), X-ray diffraction, an excellent tool in studying the lipid organisation in membranes.: CRS.
- Bouwstra J.A., Gooris G.S., Dubbelaar F.E.R., Weerheim A.M., IJzerman A.P. & Ponec-Waelsch M.H. (1998), The role of ceramide 1 in the molecular organisation of the stratum corneum lipids, 39: 186-196.
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- Skalko N., Bouwstra J.A., Spies F., Stuart M., Frederik P.M. & Gregoriadis G. (1998), Morphological observations on liposomes bearing covalently bound protein: studies with freeze-fracture and cryo-electron microscopy and small angle x-ray scattering technique, Biochimica et Biophysica Acta 1370: 151-160.
- Vicanova J., Bouwstra J.A., Weerheim A.M., Harriger M.D., Boyce S.T. & Ponec M. (1998), Stratum corneum lipid composition and structure in cultured skin substitutes is restored to normal after graphting into athymic mice, Journal of Investigative Dermatology Symposium Proceedings 3: 114-120.
- Bouwstra J.A., Dubbelaar F.E.R., Gooris G.S., Weerheim A.M. & Ponec-Waelsch M.H. (1998), The role of ceramide composition in lipid organisation of the skin barrier, Biochimica et Biophysica Acta : .
- Pilgram G.S.K., Engelsma-Van Pelt A.M., Oostergetel G.T., Koerten H.K. & Bouwstra J.A. (1998), Study on the lipid organisation of stratum corneum lipid models by cryo-electron diffraction, 39: 1669-1676.
- Bergh B.A.I. van den, Salomons-de Vries I. & Bouwstra J.A. (1998), Interactions between liposomes and stratum corneum studied by freeze-substitution electron micros-copy, 167: 57-67.
- Pilgram G.S.K., Pelt A.M. van, Spies F., Koerten H.K. & Bouwstra J.A. (1998), Cryo-electron diffraction as a tool to study local variations in the lipid organisation of human stratum corneum, Journal of Microscopy 189: 71-78.
- Kuijk-Meuwissen M.E.M.J., Janssen J.P., Cullander C., Junginger H.E. & Bouwstra J.A. (1998), A cross section device to improve visualization of fluorescent probe penetration into the skin by confocal laser scanning microscopy, PHARMACEUTICAL RESEARCH 15: 352-356.
- Kuijk-Meuwissen M.E.M.J., Junginger H.E. & Bouwstra J.A. (1998), Interactions between liposomes and human skin in vitro: a confocal laser scanning microscopy study, Biochimica et Biophysica Acta 1371: 31-39.
- Bouwstra J.A., Gooris G.S., Dubbelaar F.E.R., Weerheim A.M. & Ponec-Waelsch M.H. (1998), pH, cholesterol sulfate and fatty acids affect the stratum corneum lipid organisation, 3: 69-74.
- Kuijk-Meuwissen M.E.M.J., Mougin L., Junginger H.E. & Bouwstra J.A. (1998), Application of vesicles to rat skin in vivo: a confocal laser scanning microscopy study, JOURNAL OF CONTROLLED RELEASE 56: 189-196.
- Jadoul A., Tanojo H., Préat V., Bouwstra J.A., Spies F. & Boddé H.E. (1998), Electroperturbation of human stratum corneum fine structure by high voltage pules: a freeze-fracture electron microscopy and differential thermal analysis study, 3: 159-165.
- Ponec-Waelsch M.H., Weerheim A., Kempenaar J., Gooris G.S., Bouwstra J.A. & Mommaas-Kienhuis A.M. (1997), The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitimin C, 109: 348-355.
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