Roxanne Kieltyka
Universitair hoofddocent
- Naam
- Dr. R.E. Kieltyka
- Telefoon
- +31 71 527 4441
- r.e.kieltyka@chem.leidenuniv.nl
- ORCID iD
- 0000-0001-9152-1810
Meer informatie is beschikbaar op de Engelse profielpagina.
Nieuws
-
ERC Starting Grant voor Roxanne Kieltyka: stamcellen in gels -
Vijf ERC Starting Grants voor jonge Leidse wetenschappers -
Roxanne Kieltyka in NRC: 'Mijn droom is een goede gel voor elke cel' -
Roxanne Kieltyka geinterviewd voor Leidsch Dagblad -
Roxanne Kieltyka geinterviewd voor Nemo Kennislink -
Roxanne Kieltyka gekozen tot de Talented 12 van chemici -
DNA als supramoleculaire bouwsteen -
Ruim een miljoen voor Leids excellent onderzoek chemie
Universitair hoofddocent
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- Janssen M.L., Liu T., Özel M., Bril M., Thelu H.V.P. & Kieltyka R.E. (2024), Dynamic exchange in 3D cell culture hydrogels based on crosslinking of cyclic thiosulfinates, Angewandte Chemie (International Edition) 63(6): e202314738.
- Vittala S.K., Liu T., Zwol S. van, Feher B., Voets I.K. & Kieltyka R.E. (2024), Hydrophobic Domain Modulation of Chemical Responsiveness in a Bolaamphiphile-Based Supramolecular Monomer, ChemBioChem : e202400348.
- Boase N.R.B., Gillies E.R., Goh R., Kieltyka R.E., Matson J.B., Meng F., Sanyal A. & Sedlacek O. (2024), Stimuli-Responsive Polymers at the Interface with Biology, Biomacromolecules 25(9): 5417-5436.
- Kulala Vittala S. & Kieltyka R.E. (2023), Multi-site-specific polymer grafting from nucleic acids, Chem 9(11): 3018-3020.
- Noteborn W.E.M., Vittala S.K., Torredemer M.B., Maity C., Versluis F., Eelkema R. & Kieltyka R.E. (2023), Switching the mode of drug release from a reaction-coupled low-molecular-weight gelator system by altering its reaction pathway, Biomacromolecules 24(1): 377-386.
- Zhang X., Liu T., Boyle A.L., Bahreman A., Bao L., Jing Q., Xue H., Kieltyka R.E., Kros A., Schneider G.F. & Fu W. (2022), Dielectric-modulated biosensing with ultrahigh-frequency-operated graphene field-effect transistors, Advanced Materials 34(7): 2106666.
- Tong. C., Wondergem A.J., Brink M. van den, Kwakernaak M.C., Chen Y., Hendrix M.M.R.M., Voets I.K., Danen E.H.J., Le Dévédec S., Heinrich D.M. & Kieltyka R.E. (2022), Spatial and temporal modulation of cell instructive cues in a filamentous supramolecular biomaterial, ACS Applied Materials and Interfaces 14(15): 17042-17054.
- Zhang X., Liu T., Boyle A.L., Bahreman A., Jing Q., Xue H., Kieltyka R.E., Kros A., Schneider G.F. & Fu W. (2022), Dielectric‐modulated biosensing with ultrahigh‐frequency‐operated graphene field‐effect transistors, Advanced Materials 34(7): 2106666.
- Baker M.B., Bosman A.W., Cox M. A.J., Dankers P.Y.W., Dias A., Jonkheijm P. & Kieltyka R.E. (2022), Supramolecular biomaterials in the Netherlands, Tissue Engineering Part B: Reviews 28(11-12): 511-524.
- Liu T., Berk L. van den, Wondergem J.A.J., Tong C., Kwakernaak M.C., Braak B. ter, Heinrich D., Water B. van de & Kieltyka R.E. (2021), Squaramide‐based supramolecular materials Drive hepG2 spheroid differentiation, Advanced Healthcare Materials 10(11): 2001903.
- Saez Talens V., Arias-Alpizar G., Makurat D.M.M., Davis J., Bussmann J., Kros A. & Kieltyka R.E. (2020), Stab2-mediated clearance of supramolecular polymer nanoparticles in zebrafish embryos, Biomacromolecules 21(3): 1060-1068.
- Tong C., Wondergem J.A.J., Heinrich D. & Kieltyka R.E. (2020), Photopatternable, Branched Polymer Hydrogels Based on Linear Macromonomers for 3D Cell Culture Applications, ACS Macro Letters 9(6): 882-888.
- Saez Talens V., Davis J., Wu C.H., Wen Z., Lauria F., Gupta K., Babu Sai S., Rudge R., Boraghi M., Hagemeijer A., Trinh T., Englebienne P., Voets I.K., Wu J.L. & Kieltyka R.E. (2020), Thiosquaramide-Based Supramolecular Polymers: Aromaticity Gain in a Switched Mode of Self-Assembly, Journal of the American Chemical Society 142(47): 19907-19916.
- Meijer M.S., Saez Talens V., Hilbers M.F., Kieltyka R.E., Brouwer A.M., Natile M.M. & Bonnet S.A. (2019), NIR-Light-Driven Generation of Reactive Oxygen Species Using Ru(II)-Decorated Lipid-Encapsulated Upconverting Nanoparticles, Langmuir 35(37): 12079−12090.
- Talens V.S., Makurat D.M.M., Liu T.X., Dai W., Guibert C., Noteborn W.E.M., Voets I.K. & Kieltyka R.E. (2019), Shape modulation of squaramide-based supramolecular polymer nanoparticles, Polymer Chemistry 10(23): 3146-3153.
- Kieltyka R.E., Matson J.P. & Besenius P. (2018), Structure to Function in Supramolecular Polymers and Materials, Macromolecular Rapid Communications 39(17): 1800574.
- Askes S.H.C., Bossert N., Bussmann J., Talens V.S., Meijer M.S., Kieltyka R.E., Kros A., Bonnet S.A. & Heinrich D.M. (2018), Dynamics of dual-fluorescent polymersomes with durable integrity in living cancer cells and zebrafish embryos, Biomaterials 168: 54-63.
- Noteborn W.E.M., Wondergem A.J., Lurchenko A., Chariyez-Prinz F., Donato D.M., Voets I.K., Heinrich D.M. & Kieltyka R.E. (2018), Grafting from a hybrid DNA-covalent polymer by hybridization chain reaction, Macromolecules 51(14): 5157–5164.
- Noteborn W.E.M., Zwagerman D.N.H., Talens Saez V., Maity C., Van der Mee L., Poolman J.M., Mytnyk S., Van Esch J.H., Kros A., Eelkema R. & Kieltyka R.E. (2017), Crosslinker-Induced Effects on the Gelation Pathway of a Low Molecular Weight Hydrogel, Advanced Materials 29(12): 1603769.
- Noteborn W.E.M., Gao Y., Jesse W.J., Kros A. & Kieltyka R.E. (2017), Dual-Crosslinked Human Serum Albumin Polymer Hydrogels for Affinity-Based Drug Delivery, Macromolecular Materials and Engineering 302(10): 1700243.
- Lopez Mora N.L., Gao Y., Gutierrez M.G., Peruzzi J., Bakker I., Peters R.J.R.W., Siewert B., Bonnet S.A., Kieltyka R.E., Hest J.C.M. van, Malmstadt N. & Kros A. (2017), Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes, SOFT MATTER 13(33): 5580-5588.
- Noteborn W.E.M., Saez Talens V. & Kieltyka R.E. (2017), Reversible Loading of Nanoscale Elements on a Multicomponent Supramolecular Polymer System by Using DNA Strand Displacement, ChemBioChem 18(20): 1995-1999.
- Siewert B., Langerman M., Hontani Y., Kennis J.T.M., Rixel V.H.S. van, Limburg B., Siegler M.A., Saez Talens V., Kieltyka R.E. & Bonnet S.A. (2017), Turning on the red phosphorescence of a [Ru(tpy)(bpy)(Cl)]Cl complex by amide substitution: self- aggregation, toxicity, and cellular localization of an emissive ruthenium-based amphiphile, Chemical Communications 53: 11126-11129.
- Bakker M.H., Kieltyka R.E., Albertazzi L. & Dankers P.Y.W. (2016), Modular supramolecular ureidopyrimidinone polymer carriers for intracellular delivery, RSC Advances 2016(6): 110600-110603.
- Saez Talens V., Englebienne P., Trinh T.T., Noteborn W.E.M., Voets I.K. & Kieltyka R.E. (2015), Aromatic Gain in a Supramolecular Polymer, Angewandte Chemie (International Edition) 54(36): 10502-10506.
- López Mora N., Hansen J.S., Gao Y., Ronald A.A., Kieltyka R.E., Malmstadt N. & Kros A. (2014), Preparation of size tunable giant vesicles from cross-linked dextran(ethylene glycol) hydrogels, Chemical Communications 50(16): 1953-1955.
- Pape A.C.H., Bastings M.M.C., Kieltyka R.E., Wyss H.M., Voets I.K., Meijer E.W. & Dankers P.Y.W. (2014), Mesoscale characterization of supramolecular transient networks using SAXS and rheology, International Journal of Molecular Science 15: 1096-1111.
- Bastings M.M.C., Koudstaal S., Kieltyka R.E., Nakano Y., Pape A.C.H., Feyen D.A.M., Van Slochteren F.J., Doevendans P.A., Sluijter J.P.G., Meijer E.W., Chamuleau S.A.J. & Dankers P.Y.W. (2014), A Fast pH-Switchable and Self-Healing Supramolecular Hydrogel Carrier for Guided, Local Catheter Injection in the Infarcted Myocardium, Advanced Healthcare Materials 3(1): 70-78.
- Gao Y., Kieltyka R.E., Jesse W., Norder B., Korobko A.V. & Kros A. (2014), Thiolated human serum albumin cross-linked dextran hydrogels as a macroscale delivery system, 10(27): 4869-4874.
- Kieltyka R., Pape A.C.H., Albertazzi L., Nakano Y., Bastings M.M.C., Voets I.K., Dankers P.Y.W. & Meijer E.W. (2013), Mesoscale Modulation of Supramolecular Ureidopyrimidinone-Based Poly(ethylene glycol) Transient Networks in Water, Journal of the American Chemical Society 135(30): 11159-11164.
- Castor K.J., Mancini J., Fakhoury J., Weill N., Kieltyka R., Englebienne P., Avakyan N., Mittermaier A., Autexier C., Moitessier N. & Sleiman H.F. (2012), Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes, ChemMedChem 7(1): 85-94.
- Kieltyka R.E., Bastings M.M., Almen G.C. van, Besenius P., Kemps E.W. & Dankers P.Y. (2012), Modular synthesis of supramolecular ureidopyrimidinone-peptide conjugates using an oxime ligation strategy, Chemical Communications 48(10): 1452-4.
- Dankers P.Y.W., Hermans T.M., Baughman T.W., Kamikawa Y., Kieltyka R.E., Bastings M.M., Janssen H.M., Sommerdijk N.A., Larsen A., Luyn M.J. van, Bosman A.W., Popa E.R., Fytas G. & Meijer E.W. (2012), Hierarchical formation of supramolecular transient networks in water: a modular injectable delivery system, Advanced Materials 24(20): 2703-9.
- Kieltyka R., Englebienne P., Moitessier N. & Sleiman H. (2010), Quantifying interactions between G-quadruplex DNA and transition-metal complexes, Methods in Molecular Biology 608: 223-55.
- Pierce S.E., Kieltyka R., Sleiman H.F. & Brodbelt J.S. (2009), Evaluation of binding selectivities and affinities of platinum-based quadruplex interactive complexes by electrospray ionization mass spectrometry, Biopolymers 91(4): 233-43.
- Kieltyka R., Fakhoury J., Moitessier N. & Sleiman H.F. (2008), Platinum phenanthroimidazole complexes as G-quadruplex DNA selective binders, Chemistry: a European Journal 14(4): 1145-1154.
- Kieltyka R., Englebienne P., Fakhoury J., Autexier C., Moitessier N. & Sleiman H.F. (2008), A platinum supramolecular square as an effective G-quadruplex binder and telomerase inhibitor, Journal of the American Chemical Society 130(31): 10040-10041.
- Kieltyka R., Moitessier N. & Sleiman H.F. (2007), Platinum metallointercalators to target G-quadruplex structures, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 24(6): 706-706.