Rob van Wijk
Universitair docent
- Naam
- Dr. R.C. van Wijk
- Telefoon
- +31 71 527 4505
- r.c.van.wijk@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0001-7247-1360
Voor meer informatie, zie Engelse versie.
Promovendi
Nieuws
-
Met 30 miljoen dollar wil dit consortium tbc eronder krijgen -
Leidse onderzoekers slaan handen ineen tegen tuberculose -
'Test geneesmiddelen na vijf dagen' -
Rob van Wijk over de rol van de zebravis in medicijnonderzoek -
Leids promovenditeam door naar finale internationale farmacologische wedstrijd -
Student in faculteitsbestuur: Rob van Wijk benoemd tot nieuwe assessor
Universitair docent
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Pharmacology
- Wijk R.C. van, Mockeliunas L., Upton C.M., Peter J., Diacon A.H. & Simonsson U.S.H. (2023), Seasonal influence on respiratory tract infection severity including COVID‐19 quantified through Markov Chain modeling, CPT: Pharmacometrics & Systems Pharmacology 12(9): 1250-1261.
- Wijk R.C., Imperial M.Z. Savic R.M. & Solans B.P. (2023), Pharmacokinetic analysis across studies to drive knowledge‐integration: a tutorial on individual patient data meta‐analysis (IPDMA), CPT: Pharmacometrics & Systems Pharmacology 12(9): 1187-1200.
- Wijk R.C. van, Ainhoa L., Sudhakar P.K., Sonnenkalb L., Gaudin C., Hoffmann E., Dremierre B., Aguilar-Ayala D.A., Molin M.D., Rybniker J., De Giorgi S., Cioetto-Mazzabò L., Segafreddo G., Manganelli R., Degiacomi G., Recchia D., Pasca M.R.,Simonsson U.S.H. & Ramón-García S. (2023), Implementing best practices on data generation and reporting of mycobacterium tuberculosis in vitro assays within the ERA4TB consortium, iScience 26(4): 106411.
- Mockeliunas L., Faraj A., Wijk R.C. van, Upton C.M., Hoogen G. van den, Diacon A.H. & Simonsson U.S.H. (2023), Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development, Frontiers in Pharmacology 14: 1150243.
- Faraj A., Wijk R.C. van, Neuman L., Desai S., Blouse G.E., Knudsen T. & Simonsson U.S.H. (2023), Model‐informed pediatric dose selection of marzeptacog alfa (activated): an exposure matching strategy, CPT: Pharmacometrics & Systems Pharmacology 12(7): 977-987.
- Ernest J.P., Goh J.J.N., Strydom N., Wang Q., Wijk R.C. van, Zhang N., Deitchman A., Nuermberger E. & Savic R.M. (2023), Translational predictions of phase 2a first-in-patient efficacy studies for antituberculosis drugs, European Respiratory Journal 62(2): 2300165.
- Wijk R.C. van & Simonsson U.S.H. (2022), Finding the right hazard function for time‐to‐event modeling: a tutorial and shiny application, CPT: Pharmacometrics & Systems Pharmacology 11(8): 991-1001.
- Upton C.M., Wijk R.C. van, Mockeliunas L., Simonsson U.S.H., McHarry K., Hoogen G. van den, Muller C.,Delft Arne von, Westhuizen H.-M. van der, Crevel R. van, Walzl G., Baptista P.M., Peter J. & Diacon A.H. (2022), Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: a double-blind, randomised, controlled, phase 3 trial, EClinicalMedicine 48: 101414.
- De Jager V., Gupte N., Nunes S., Barnes G.L., Wijk R.C. van, Mostert J., Dorman S.E., Abulfathi A. A., Upton C.M., Faraj A., Nuermberger E.L., Lamichhane G., Svensson E.M., Simonsson U.S.H., Diacon A.H. & Dooley K.E. (2022), Early bactericidal activity of meropenem plus clavulanate (with or without rifampin) for tuberculosis: the COMRADE randomized, phase 2A clinical trial, American Journal of Respiratory and Critical Care Medicine 205(10): 1228-1235.
- Tang X., Spaink H.A.J., Wijk R.C. van & Verbeek F.J. (2020), Segmentation-driven optimization for iterative reconstruction in optical projection tomography: an exploration, IEEE Transactions on Computational Imaging 6: 1537-1547.
- Wijk R.C. van (6 februari 2020), Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods (Dissertatie. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University). Promotor(en) en copromotor(en): Graaf P.H. van der & Spaink H.P., Krekels E.H.J.
- Wijk R.C. van, Sar A.M. van der, Krekels E.H.J., Verboom T., Spaink H.P., Simonsson U.S.H. & Graaf P.H. van der (2020), Quantification of natural growth of two strains of Mycobacterium marinum for translational anti‐tuberculosis drug development, Clinical and Translational Science 13(6): 1060-1064.
- Wijk R.C. van, Hu W.B., Dijkema S.M., Berg D. van den, Liu J., Bahi R., Verbeek F.J., Simonsson U.S.H., Spaink H.P., Graaf P.H. van der & Krekels E.H.J. (2020), Anti-tuberculosis effect of isoniazid scales accurately from zebrafish to humans, British Journal of Pharmacology 177(24): 5518-5533.
- Wijk R.C. van, Krekels E.H.J., Kantae V., Harms A.C., Hankemeier T., Graaf P.H. van der & Spaink H.P. (2019), Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae, Scientific Reports 9: 2149.
- Wijk R.C. van, Krekels E.H.J., Kantae V., Ordas A., Kreling T., Harms A.C., Hankemeier T., Spaink H.P. & Graaf P.H. van der (2019), Mechanistic and quantitative understanding of pharmacokinetics in zebrafish larvae through nanoscale blood sampling and metabolite modelling of paracetamol, Journal of Pharmacology and Experimental Therapeutics 371(1): 15-24.
- Wong Y.C., Ilkova T.I., Wijk R.C. van, Hartman R.J. & Lange E.C.M. de (2018), Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in nonanesthetized rat, European Journal of Pharmaceutical Sciences 111: 514–525.
- Schulthess P., Wijk R.C. van, Krekels E.H.J., Yates J.W.T., Spaink H.P. & Graaf P.H. van der (2018), Outside-in systems pharmacology combines innovative computational methods with high-throughput whole vertebrate studies, CPT: Pharmacometrics and Systems Pharmacology 7(5): 285-287.
- Wijk R.C. van, Krekels E.H.J., Hankemeier T., Spaink H.P. & Graaf P.H. van der (2017), Systems pharmacology of hepatic metabolism in zebrafish larvae, Drug Discovery Today: Disease Models 22: 27-34.
- Guo Y., Wijk R.C. van, Krekels E.H.J., Spaink H.P., Graaf P.H. van der & Verbeek F.J. (2017), Multi-modal 3D reconstruction and measurements of zebrafish larvae and its organs using axial-view microscopy, 2017 IEEE International conference on image processing (ICIP). IEEE International Conference on Image Processing 2017 17 september 2017 - 20 september 2017: IEEE Xplore. 2194-2198.
- Kantae V., Krekels E.H.J., Ordas A.K., Gonzalez O., Wijk R.C. van, Harms A.C., Racz P.I., Graaf P.H. van der, Spaink H.P. & Hankemeier T. (2016), Pharmacokinetic modeling of paracetamol uptake and clearance in zebrafish larvae: expanding the allometric scale in vertebrates with five orders of magnitude, Zebrafish 13(6): 504-510.
- Bellanti F., Wijk R.C. van, Danhof M. & Della Pasqua O.E. (2015), Integration of PKPD relationships into benefit-risk analysis, British Journal of Clinical Pharmacology 80(5): 979-991.
- Chair LMIC Accelerator program
- Chair Global Health Community