Martina Huber
Universitair hoofddocent
- Naam
- Dr. M.I. Huber
- Telefoon
- +31 71 527 5560
- huber@physics.leidenuniv.nl
- ORCID iD
- 0000-0001-7632-1968
Meer informatie over Martina Huber
Nieuws
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Onderzoek naar ferritine: ‘we hopen dat dit uiteindelijk meer inzicht geeft in Alzheimer’ -
Speuren naar de bron van vergeetachtigheid -
Alzheimer-eiwit betrapt op klonteren -
NWA Ideeëngenerator-subsidie voor nano-ijzerdeeltjes in het brein -
Nacht van Ontdekkingen bomvol bètawetenschappers -
Fysici linken specifieke ijzervormen aan Alzheimer -
Vrouwelijke onderzoekers in de spotlight voor Physics Ladies Day -
Werking versterkstoffen MRI in kaart gebracht -
Nieuwe techniek om notoir Alzheimer-eiwit te betrappen
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Specifiek eiwit in de hoofdrol bij ziekte van Parkinson -
Ruim een miljoen voor Leids excellent onderzoek chemie -
Losse eindjes in eiwitten bevorderen fotosynthese
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Hoefijzereiwit schakel in Parkinson -
Hoefijzervormige ‘Parkinsoneiwitten’ vormen klonten
In de media
Oud-promovendi
Universitair hoofddocent
- Wiskunde en Natuurwetenschappen
- Leiden Instituut Onderzoek Natuurkunde
- LION - Biological & Soft Matter
- Polanco Rivas E.A., Opdam L.V., Passerini L., Huber M.I., Bonnet S.A. & Pandit A. (2024), An artificial metalloenzyme that can oxidize water photocatalytically: design, synthesis, and characterization, Chemical Science 15(10): 3596-3609.
- Bossoni L., Labra-Munoz J.A., Zant H.S.J. van der, Calukovic V., Lefering A., Egli R. & Huber M.I. (2023), In-depth magnetometry and EPR analysis of the spin structure of human-liver ferritin: from DC to 9 GHz, Physical Chemistry Chemical Physics 25(40): 27694-27717.
- Bobylev E.O., Passerini L., Zwart F.J. de, Poole D.A., Mathew S., Huber M., Bruin B. de & Reek J.N.H. (2023), Pd12MnL24 (for n = 6, 8, 12) nanospheres by post-assembly modification of Pd12L24 spheres, Chemical Science 14(42): 11840-11849.
- Zurlo E., Passerini L., Kumar P. & Huber M. (2022), In situ continuous wave electron paramagnetic resonance investigation of the amyloid aggregation of Parkinson's protein alpha-synuclein-the second spin label position, Applied Magnetic Resonance 53: 1133–1150.
- Klein D.M., Passerini L., Huber M.I. & Bonnet S.A. (2022), A stable alkylated cobalt catalyst for photocatalytic H2 generation in liposomes, ChemCatChem 14(20): e202200484.
- Labra Munoz J.A., Reuver A. de, Koeleman F., Huber M.I. & Zant H.S.J. van der (2022), Ferritin-Based Single-Electron Devices, Biomolecules 12(5): 705.
- Zurlo E., Kumar P., Meisl G., Dear A.J., Mondal D., Claessens M.M.A.E., Knowles T.P.J. & Huber M.I. (2021), In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers, PLoS ONE 16(1): e0245548.
- Vroegindeweij L.H.P., Bossoni L., Boon A.J.W., Wilson J.H.P., Bulk M., Labra-Muñoz J., Huber M., Webb A., Weerd L. van der & Langendonk J.G. (2021), Quantification of different iron forms in the aceruloplasminemia brain to explore iron-related neurodegeneration, NeuroImage: Clinical 30: 102657.
- Nami F., Tian L., Huber M.I., Croce R. & Pandit A. (2021), Lipid and protein dynamics of stacked and cation-depletion induced unstacked thylakoid membranes, BBA Advances 1: 100015.
- Miao Q., Zurlo E., Bruin D. de, Wondergem J.A.J., Skinner S.P., Timmer M., Cramer A.J., Heinrich D.M., Overhand M. & Huber M.I. (2021), Corrigendum: a two-armed probe for in-cell DEER measurements on proteins (vol 26, pg 17128, 2020), Chemistry: a European Journal 27(23): 6994-6994.
- Son M. van, Schilder J.T., Di Savino A., Blok A.J., Ubbink M. & Huber M.I. (2020), The transient complex of cytochrome c and cytochrome c peroxidase: insights into the encounter complex from multifrequency EPR and NMR spectroscopy, ChemPhysChem 21(10): 1060-1069.
- Miao Q., Zurlo E., Bruin D. de, Wondergem A.J., Timmer M., Blok A.J., Heinrich D.M., Overhand M., Huber M.I. & Ubbink M. (2020), A two‐armed probe for in‐cell DEER measurements on proteins, Chemistry: a European Journal 26(71): 17128-17133.
- Zurlo E., Gorroño Bikandi I., Meeuwenoord N.J., Filippov D.V. & Huber M.I. (2019), Tracking amyloid oligomerization with monomer resolution using a 13-amino acid peptide with a backbone-fixed spin label, Physical Chemistry Chemical Physics 21(45): 25187-25195.
- Kumar P., Son M. van, Zheng T., Raap J., Kros A. & Huber M.I. (2018), Coiled-coil Formation of the Membrane-Fusion K/E Peptides Viewed by Electron Paramagnetic Resonance, 13(1): e0191197.
- Bulk M., Weerd L. van der, Breimer W., Lebedev N., Webb A., Goeman J.J., Ward R.J., Huber M.I., Oosterkamp T.H. & Bossoni L. (2018), Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects, Scientific Reports 8: 6898.
- Gerolin M., Zerbetto M., Moretto A., Formaggio F., Toniolo C., Son M. van, Hashemi Shabestari M., Huber M.I., Calligari P. & Polimeno A. (2017), Integrated Computational Approach to the Electron Paramagnetic Resonance Characterization of Rigid 310-Helical Peptides with TOAC Nitroxide Spin Labels, Journal of Physical Chemistry B 121(17): 4379-4387.
- Bossoni L., Grand Moursel L., Bulk M., Simon B.G., Webb A., Weerd L. van der, Huber M.I., Carretta P., Lascialfari A. & Oosterkamp T.H. (2017), Human-brain ferritin studied by muon spin rotation: a pilot study, Journal of Physics: Condensed Matter 29(41): 415801.
- Gast P., Mance D., Zurlo E., Ivanov K.L., Baldus M. & Huber M.I. (2017), A tailored multi-frequency EPR approach to accurately determine the magnetic resonance parameters of dynamic nuclear polarization agents: application to AMUPol, Physical Chemistry Chemical Physics 19(5): 3777-3781.
- Kumar P., Schilderink N., Subramaniam V. & Huber M.I. (2017), Membrane Binding of Parkinson's Protein alpha-Synuclein: Effect of Phosphorylation at Positions 87 and 129 by the S to D Mutation Approach, Israel Journal of Chemistry 57(7-8): 762-770.
- Zurlo E., Meeuwenoord M.J., Filippov D.V. & Huber M.I. (2017), Rigid Spin Labels for Improved Distance and Dynamics in Intrinsically Disordered Proteins and Peptides, Biophysical Journal 112(3): 316A.
- Kumar P., Shabestari M.H., Schilderink N., Segers-Nolten I.M.J., Claessens M.M.A.E., Subramaniam V. & Huber M.I. (2017), The Alpha-Synuclein Fibril Fold - Comparing Models from Electron Paramagnetic Resonance and NMR, Supplemant, Biophysical Journal 112(3): 447A.
- Verhagen T.G.A., Tinkey H.N., Overweg H.C., Son M. van, Huber M.I., Ruitenbeek J.M. van & Aarts J. (2016), Temperature dependence of spin pumping and Gilbert damping in thin Co/Pt bilayers, Journal of Physics: Condensed Matter 28(5): 056004.
- Kumar P., Bulk M., Webb A., Weerd L. van der, Oosterkamp T.H., Huber M.I. & Bossoni L. (2016), A novel approach to quantify different iron forms in ex-vivo human brain tissue, Scientific Reports 6: 38916.
- Schilder J., Liu W.M., Kumar P., Overhand M., Huber M.I. & Ubbink M. (2016), Protein docking using an ensemble of spin labels optimized by intra-molecular paramagnetic relaxation enhancement, Physical Chemistry Chemical Physics 18(8): 5729-5742.
- Hashemi Shabestari M., Meeuwenoord N.J., Filippov D.V. & Huber M.I. (2016), Interaction of the amyloid β peptide with sodium dodecyl sulfate as a membrane-mimicking detergent, Journal of Biological Physics 42(3): 299-315.
- Schilder J., Liu W.M., Kumar P., Overhand M., Huber M.I. & Ubbink M. (2016), Protein docking using an ensemble of spin labels optimized by intra-molecular paramagnetic relaxation enhancement, Physical Chemistry Chemical Physics 18(8): 5729-5742.
- Dimitrova A., Walko M., Hashemi Shabestari M., Kumar P., Huber M.I. & Kocer A. (2016), In situ, Reversible Gating of a Mechanosensitive Ion Channel through Protein-Lipid Interactions, Frontiers in Physiology 7(409): 1-9.
- Kumar P., Segers-Nolten I.M.J., Schilderink N., Subramaniam V. & Huber M.I. (2015), Parkinson’s Protein α-Synuclein Binds Efficiently and with a Novel Conformation to Two Natural Membrane Mimics, PLoS ONE 10(11): e0142795.
- Hashemi Shabestari M., Kumar P., Segers-Nolten I.M.J., Claessens M.M.A.E., Rooijen B.D. van, Subramaniam V. & Huber M.I. (2015), Three Long-Range Distance Constraints and an Approach Towards a Model for the α-Synuclein-Fibril Fold, Applied Magnetic Resonance 46: 369-388.
- Mance D., Gast P., Huber M.I., Baldus M. & Ivanov K.L. (2015), The magnetic field dependence of cross-effect dynamic nuclear polarization under magic angle spinning, The Journal of Chemical Physics 142: 234201.
- Son M. van, Lindhoud S., Wild M. van der, Mierlo C.P.M. van & Huber M.I. (2015), Double electron−electron spin resonance tracks flavodoxin folding, The Journal of Physical Chemistry B 119(43): 13507-13514.
- Scarpelli F., Arrieta A.L., Gast P., Groenen E.J.J., Milikisyants S., Murphy M.E.P. & Huber M. (2015), A Single-Crystal EPR Study at 95 GHz of the Type-2 Copper Site of Nitrite Reductase From Alcaligenes faecalis, Applied Magnetic Resonance 46: 411-420.
- Gloaguen Y., Rebreyend C., Lutz M., Kumar P., Huber M.I., Vlugt J.I. van der, Schneider S. & Bruin B. de (2014), An isolated Nitridyl radical-bridged {Rh(N∙)Rh} complex, Angewandte Chemie - International Edition in English 53: 6814-6818.
- Hashemi Shabestari M., Wolfs C.J.A.M., Spruijt R.B., Amerongen H. van & Huber M.I. (2014), Exploring the structure of the 100 Amino-Acid residue long N-terminus of the plant antenna protein CP29, Biophysical Journal 106: 1349-1358.
- Hashemi Shabestari M., Son M. van, Moretto A., Crisma M., Toniolo C. & Huber M.I. (2014), Conformation and EPR characterization of rigid, 3^10-helical peptides with TOAC spin labels: models for short distances, 102: 244-251.
- Hashemi Shabestari M., Plug T., Motazacker M.M., Meeuwenoord N.J., Filippov D.V., Meijers J.C.M. & Huber M.I. (2013), The Aggregation Potential of the 1–15- and 1–16- Fragments of the Amyloid b Peptide and Their Influence on the Aggregation of Ab40, Applied Magnetic Resonance 44: 1167-1179.
- Huber M.I. (2013), EPR approaches to disorder in proteins, Specialist Periodical Reports : Electron Paramagnetic Resonance / of the Royal Society of Chemistry : 23: 79-102.
- Drescher M., Huber M.I. & Subramaniam V. (2012), Hunting the Chameleon: Structural Conformations of the Intrinsically Disordered Protein Alpha-Synuclein, ChemBioChem 13: 761-768.
- Scanu S., Förster J., Finiguerra M.G., Hashemi Shabestari M., Huber M.I. & Ubbink M. (2012), The Complex of Cytochrome f and Plastocyanin from Nostoc sp. PCC 7119 is Highly Dynamic, ChemBioChem 13: 1312-1318.
- Shabestari M.H., Meeuwenoord N.J., Filippov D.V. & Huber M.I. (2012), The Effect of a Membrane Mimicking Detergent on Alzheimer's Amyloid Peptide Aggregation Studied by EPR, Biophysical Journal 102: .
- Shabestari M.H., Segers-Nolten I.M.J., Claessens M.M.A.J., Rooijen B.D. van, Subramaniam V. & Huber M.I. (2012), Elucidating the Alpha-Synuclein Fibril Fold by Pulsed EPR, Biophysical Journal 102: .
- Robotta M., Hintze C., Schildknecht S., Zijlstra N., Jungst C., Karreman C., Huber M.I., Leist M., Subramaniam V. & Drescher M. (2012), Locally Resolved Membrane Binding Affinity of the N-Terminus of alpha-Synuclein, Biochemistry 51: 3960-3962.
- Huber M.I. (2011), Protein Structure with Electron Paramagnetic Resonance Eyes, Eureka 32: .
- Carlotto S., Zerbetto M., Shabestari M.H., Moretto A., Formaggio F., Crisma M., Toniole C., Huber M.I. & Polimeno A. (2011), In Silco Interpretation of cw-ESR at 9 and 95 GHZ of Mono- and bis- TOAC-Labeled Aib-Homopeptides in Fluid and Frozen Acetonitrile, Journal of Physical Chemistry B 115(44): 13026-13036.
- Robotta M., Braun P., Rooijen B. van, Subramaniam V., Huber M.I. & Drescher M. (2011), Direct evidence of coexisting horseshoe and extended helix conformations of membrane-bound alpha-Synuclein, ChemPhysChem 12(2): 267-269.
- Drescher M., Rooijen B.D. van, Veldhuis G., Subramaniam V. & Huber M.I. (2010), A stable lipid-induced aggregate of alpha-synuclein, Journal of American Chemical Society 132(12): 4080-4082.
- Shabestari M.H., Sepkhanova I., Drescher M., Meeuwenoord N.J., Limpens R.W.A.L., Koning R.I., Filippov D.V. & Huber M.I. (2010), Monitoring Alzheimer amyloid peptide aggregation by EPR. Annual Dutch Meeting on Molecular and Cellular Biophysics. Veldhoven.
- Milikisyants S., Scarpelli F., Finiguerra M.G., Ubbink M., Groenen E.J.J. & Huber M.I. (2010), Novel approaches for distance determination by EPR: large anisotropy, fast relaxing paramagnetic centres, such as Fe(III), as markers, Biophysical Journal 98(3): 399a.
- Sepkhanova I., Drescher M., Meeuwenoord N.J., Limpens R.W.A.L., Koning R., Filippov D.V. & Huber M.I. (2009), Monitoring Alzheimer Amyloid Peptide Aggregation by EPR, Applied Magnetic Resonance 36(2-4): 209-222.
- Huber M.I. (2009), Introduction to magnetic resonance methods in photosynthesis, Photosynthesis Resonance 102: 305-310.
- Scarpelli F., Drescher M., Rutters-Meijneke T., Holt A., Rijkers D.T.S., Killian J.A. & Huber M.I. (2009), Aggregation of transmembrane peptides studied by spin-label EPR, Journal of Physical Chemistry B 113: 12257-12264.
- Milikisyants S., Scarpelli F., Finiguerra M.G., Ubbink M. & Huber M.I. (2009), A pulsed EPR method to determine distances between paramagnetic centers with strong spectral anisotropy and radicals: The dead-time free RIDME sequence, Journal of Magnetic Resonance 201(1): 48-56.
- Drescher K.M., Godschalk F., Veldhuis G., Rooijen B.D. van, Subramaniam V. & Huber M.I. (2008), Spin-Label EPR on α-Synuclein Reveals Differences in the Membrane Binding Affinity of the Two Antiparallel Helices (p NA), ChemBioChem 9: 2411-2416.
- Finiguerra M.G., Prûdencio M., Ubbink M. & Huber M.I. (2008), Accurate long-range distance measurements in a doubly spin-labeled protein by a four-pulse, double electron-electron resonance method, Magnetic Resonance in Chemistry 46: 1096-1101.
- Drescher K.M., Veldhuis G., Rooijen B.D. van, Milikisyants S., Subramaniam V. & Huber M.I. (2008), Antiparallel arrangement of the helices of vesicle-bound α-synuclein, Journal of the American Chemical Society 130: 7796-7797.
- Bell C., Milikisyants S., Huber M.I. & Aarts J. (2008), Spin dynamics in a superconductor-ferromagnet proximity system, Physical Review Letters 100(4): 047002.
- Milikisyants S., Groenen E.J.J. & Huber M.I. (2008), Observer-selective double electron-electron-spin resonance, a pulse sequence to improve orientation selection, Journal of Magnetic Resonance 192(2): 275-279.
- Bono D.H.F., Hartig J., Huber M.I., Schnöckel H. & Jongh L.J. de (2007), 27Al NMR study of the Metal cluster compound Al50C120H180, J. of Cluster Science 18: 319-331.
- Benisvy L., Kannappan R., Song Y.F., Milikisyants S., Huber M.I., Mutikainen I., Turpeinen U., Gamez P., Bernasconi L., Baerends E.J., Hartl F. & Reedijk J. (2007), A Square-Planar Nickel(II) Monoradical Complex With a Bis(Salicylidene)-Diamine Ligand, European Journal of Inorganic Chemistry 2007(5): 637-642.
- Gajula P., Milikisyants S., Steinhoff H.-J. & Huber M.I. (2007), A Short Note on Orientation selection in the DEER experiments on a native cofactor and a spin label in the reaction centre of Rhodobacter sphaeroides, Applied Magnetic Resonance 31: 99-104.
- Finiguerra M.G., Blok H., Ubbink M. & Huber M.I. (2006), High-field (275 GHz) Spin-Label EPR for High-Resolution Polarity Determination in Proteins, Journal of Magnetic Resonance 180: 197-202.
- Borovykh I.V., Ceola S., Gajula P., Gast P., Steinhoff H.-J. & Huber M.I. (2006), Distance between a native cofactor and a spin label in the reaction centre of Rhodobacter sphaeroides by a two-frequency pulsed electron paramagnetic resonance method and molecular dynamics simulation, Journal of Magnetic Resonance 180(2): 178-185.
- Gajula P., Borovykh I.V., Beier C., Gast P., Huber M.I. & Steinhoff H.-J. (2006), A study on the structure and dynamics of spin labeled proteins by MD simulations and EPR spectroscopy. Meinke J., Zimmermann O., Mohanty S. & Hansmann U.H.E. (red.), Proceedings of the NIC workshop on 'From Computational Biophysics to Systems Biology 2006'. NIC Workshop 2006 From Computational Biophysics to Systems Biology 2006 6 juni 2006 - 9 juni 2006: John von Neumann Institute for Computing. 145-148.
- Fittipaldi M., Warmerdam G.C.M., Waal E.C. de, Canters G.W., Cavazzini D., Rossi G., Huber M.I. & Groenen E.J.J. (2006), Spin-density distribution in the copper site of azurin, ChemPhysChem 7(6): 1286-1293.
- Fittipaldi M., Wijma H.J., Verbeet M.P., Canters G.W. & Huber M.I. (2006), The electronic structure of the two copper sites in nitrite reductase by 9 and 95 GHz EPR on cavity mutants, Applied Magnetic Resonance 30: 417-426.
- Fittipaldi M., Wijma H.J., Verbeet M.P., Canters G.W., Groenen E.J.J. & Huber M.I. (2005), The substrate-bound type 2 copper site of nitrite reductase: the nitrogen hyperfine coupling of nitrite revealed by pulsed EPR, Biochemistry 44(46): 15193-15202.
- Steigmiller S., Börsch M., Gräber P. & Huber M.I. (2005), Distances between the b-subunits in the tether domain of F0F1-ATP synthase from E. coli, Biochimica et Biophysica Acta 1708: 143-153.
- Tanase S., Bouwman E., Reedijk J., Driessen W.L., Ferbinteanu M., Huber M., Mills A.M. & Spek A.L. (2004), Synthesis and structural studies of two new base adducts of bis(2,4-pentanedionato)cobalt(II), European Journal of Inorganic Chemistry 2004(9): 1963-1969.
- Diederix R.E.M., Fittipaldi M., Worrall J.A.R., Huber M.I., Ubbink M. & Canters G.W. (2003), Kinetic stability of the peroxidase activitity of unfoled cytochrome c: heme degradation and catalyst inactivation by hydrogen peroxide, Inorganic Chemistry 42(22): 7249-7257.
- Finiguerra M.G., Amsterdam I.M.C. van, Alagaratnam S., Ubbink M. & Huber M.I. (2003), Anisotropic spin label mobilities in azurin from 95 GHz electron paramagnetic resonance spectroscopy, Chemical Physics Letters 382: 528-533.
- Amsterdam I.M.C. van, Ubbink M., Canters G.W. & Huber M.I. (2003), Measurememt of a Cu-Cu distance of 26 a by a pulsed EPR method, Angewandte Chemie - International Edition in English 42(1): 62-64.
- Wijma H.J., Boulanger M.J., Molon A., Fittipaldi M., Huber M.I., Murphy M.E.P., Verbeet M.P. & Canters G.W. (2003), Reconstitution of the type-1 active site of the H145G/A variants of Nitrite Reductase by ligand insertion, Biochemistry 42(14): 4075-4083.
- Fittipaldi M., Steiner R.A., Matsushita M., Dijkstra B.W., Groenen E.J.J. & Huber M.I. (2003), Single-crystal EPR study at 95 GHz of the type 2 copper site of the inhibitor-bound querceting 2,3-dioxygenase, Biophysical Journal 85(6): 4047-4054.
- Ubbink M., Worrall J.A.R., Canters G.W., Groenen E.J.J. & Huber M.I. (2002), Paramagnetic resonance of biogical metal centers, Annual Review of Biophysics 31: 393-422.
- Kooter I.M., Steiner R.A., Dijkstra B.W., Noort P.I., Egmond M.R. & Huber M.I. (2002), EPR characterisation of the mononuclear Cu-containing Aspergillus japonicus quercetin 2,3-dioxygenase reveals dramatic changes upon anaerobic binding of substrates, 269: 2971-2979.
- Gastel M. van, Boulanger M.J., Canters G.W., Huber M.I., Murphy M.E.P., Verbeet M.P. & Groenen E.J.J. (2001), A single-crystal Electron Paramagnetic Resonance study at 95 GHz of the type 1 copper site of the green nitrite reductase of Alcaligenes faecalis, The Journal of Physical Chemistry B 105(11): 2236-2243.
- Gibbs S., Silva Pinto A.N., Murli S, Huber M.I., Ponec-Waelsch M.H. & Hohl D. (2000), Epidermal growth factor and keratinocyte growth factor differentially regulate epidermal migration, growth, and differentiation, Wound Repair and Regeneration 8: 192-203.