Elke Krekels
Gastmedewerker
- Naam
- Dr. E.H.J. Krekels
- Telefoon
- +31 71 527 2727
- e.h.j.krekels@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0001-6006-1567
Voor meer info over Elke Krekels, zie de Engelstalige profielpagina.
Meer informatie over Elke Krekels
Promovendi
Nieuws
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Medicijnafbraak bij kinderen: wat gebeurt er in de nieren? -
Virtuele kinderen helpen ontwenningsverschijnselen bij echte kinderen voorkomen -
Elke Krekels bij Science071: Hoe bepaal je de juiste medicijndosering voor kinderen? -
Hoe bepaal je de juiste geneesmiddeldosering voor een kind?
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Elke Krekels ontvangt Publicatieprijs Nederlandse Vereniging van Klinische Farmacologie -
Proefschrift leidt tot nieuw doseervoorschrift morfine voor baby’s en peuters
Meer informatie over Elke Krekels op haar Engelstalige profielpagina.
Gastmedewerker
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Pharmacology
- Di X., Martinez-Tellez B., Krekels E.H.J., Jurado-Fasoli L., Osuna-Prieto F.J., Ortiz-Alvarez L., Hankemeier T., Rensen P.C.N., Ruiz J.R. & Kohler I. (2024), Higher plasma levels of endocannabinoids and analogues correlate with a worse cardiometabolic profile in young adults, The Journal of Clinical Endocrinology and Metabolism 109(5): 1351-1360.
- Zhang T., Calvier E.A.M., Krekels E.H.J. & Knibbe C.A.J. (2024), Impact of obesity on hepatic drug clearance: what are the influential variables?, AAPS Journal 26(3): 59.
- Wu Y., Allegaert K., Flint R.B., Goulooze S.C., Valitalo P.A.J., Hoog M. de, Mulla H., Sherwin C.M.T., Simons S.H. P., Krekels E.H.J., Knibbe C.A.J. & Völler S. (2024), When will the glomerular filtration rate in former preterm neonates catch up with their term peers?, Pharmaceutical Research 41(4): 637-649.
- Valkengoed D.W. van, Krekels E.H.J. & Knibbe C.A.J. (2024), All you need to know about allometric scaling: an integrative review on the theoretical basis, empirical evidence, and application in human pharmacology, Clinical Pharmacokinetics : .
- Chen L., Krekels E.H.J., Heijnen A.R., Knibbe C.A.J. & Brüggemann R.J. (2023), An integrated population pharmacokinetic analysis for posaconazole oral suspension, delayed-release tablet, and intravenous infusion in healthy volunteers, Drugs 83: 75-86.
- Zhang T., Smit C., Sherwin C.M.T., Knibbe C.A.J. & Krekels E.H.J. (2023), Vancomycin clearance in obese adults is not predictive of clearance in obese adolescents, Clinical Pharmacokinetics 62(5): 749-759.
- Liu F., Aulin L.B.S. & Manson M.L. Krekels E.H.J. Hasselt J.G.C. van (2023), Unraveling the effects of acute inflammation on pharmacokinetics: a model-based analysis focusing on renal glomerular filtration rate and cytochrome P450 3A4-mediated metabolism, European Journal of Drug Metabolism and Pharmacokinetics 48: 623–631.
- Wu Y., Völler S., Krekels E.H.J., Roofthooft D.W.E., Simons S.H.P., Tibboel D., Flint R.B. & Knibbe C.A.J. (2023), Maturation of paracetamol elimination routes in preterm neonates born below 32 weeks of gestation, Pharmaceutical Research 40(9): 2155-2166.
- Jurado-Fasoli L., Di X., Sanchez-Delgado G., Yang W., Osuna-Prieto F.J., Ortiz-Alvarez L., Krekels E., Harms A.C., Hankemeier T., Schonke C., Aguilera C.M., Llamas-Elvira J.M., Kohler I., Rensen P.C.N., Ruiz J.R. & Martinez-Tellez B. (2022), Acute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial, EBioMedicine 85: 104313.
- Jurado-Fasoli L., Di X.Y., Kohler I., Osuna-Prieto F.J., Hankemeier T., Krekels E.H.J., Harms A.C., Yang W., Garcia-Lario J.V., Fernandez-Veledo S., Ruiz J.R., Rensen P.C.N. & Martinez-Tellez B. (2022), Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults, Obesity 30(1): 50-61.
- Liu F., Aulin L.B.S., Guo T., Krekels E.H.J., Moerland M., Graaf P.H. van der & Hasselt J.G.C. van (2022), Modelling inflammatory biomarker dynamics in a human lipopolysaccharide (LPS) challenge study using delay differential equations, British Journal of Clinical Pharmacology 88(12): 5420-5427.
- Rongen A. van, Krekels E.H.J., Calvier E.A.M., Wildt S.N. de, Vermeulen A. & Knibbe C.A.J. (2022), An update on the use of allometric and other scaling methods to scale drug clearance in children: towards decision tables, Expert Opinion on Drug Metabolism & Toxicology 18(2): 99-113.
- Rhee K.P. van, Smit C., Wasmann R.E., Linden P.D. van der, Wiezer R., Dongen E.P. A. van, Krekels E.H.J., Brüggemann R.J.M. & Knibbe C.A.J. (2022), Ciprofloxacin pharmacokinetics after oral and intravenous administration in (morbidly) obese and non-obese individuals: a prospective clinical study, Clinical Pharmacokinetics 61(8): 1167-1175.
- Zhang T., Krekels E.H.J., Smit C. & Knibbe C.A.J. (2022), Drug pharmacokinetics in the obese population: challenging common assumptions on predictors of obesity-related parameter changes, Expert Opinion on Drug Metabolism & Toxicology 18(10): 657-674.
- Wu Y.J., Allegaert K., Flint R.B., Simons S.H.P., Krekels E.H.J., Knibbe C.A.J. & Völler S. (2022), Prediction of glomerular filtration rate maturation across preterm and term neonates and young infants using inulin as marker, AAPS Journal 24(2): 38.
- Engbers A.G.J., Völler S., Flint R.B., Goulooze S.C., Klerk J. de, Krekels E.H.J., Dijk M. van, Willemsen S.P., Reiss I.K.M., Knibbe C.A.J. & Simons S.H.P. (2022), The effect of ibuprofen exposure and patient characteristics on the closure of the patent Ductus Arteriosus in preterm infants, Clinical Pharmacology & Therapeutics 112(2): 307-315.
- Chen L., Rhee K.P. van, Wasmann R.E., Krekels E.H.J., Wiezer M.J., Dongen E.P.A., Verweij P.E., Linden P.D., Bruggemann R.J. & Knibbe C.A.J. (2022), Total bodyweight and sex both drive pharmacokinetic variability of fluconazole in obese adults, Journal of Antimicrobial Chemotherapy 77(8): 2217-2226.
- Jurado-Fasoli L., Yang W., Kohler I., Dote-Montero M., Osuna-Prieto F.J., Di X., Hankemeier T., Krekels E.H.J., Harms A.C., Castillo M.J., Amaro-Gahete F.J. & Martinez-Tellez B. (2022), Effect of different exercise training modalities on fasting levels of oxylipins and endocannabinoids in middle-aged sedentary adults: a randomized controlled trial, International Journal of Sport Nutrition and Exercise Metabolism 32(4): 275-284.
- He B.S., Di X., Gulded F., Harder A.V.E., Maagdenberg A.M.J.M. van den, Terwindt G.M., Krekels E.H.J., Kohler I., Harms A.C., Ramautar R. & Hankemeier T. (2022), Quantification of endocannabinoids in human cerebrospinal fluid using a novel micro-flow liquid chromatography-mass spectrometry method, Analytica Chimica Acta 1210: 339888.
- Groen B.D. van, Krekels E.H.J., Mooij M.G. Duijn E. van Vaes W.H.J., Windhorst A.D.,Rosmalen J. Hartman S.J.F., Hendrikse N.H., Koch B.C.P., Allegaert K., Tibboel D., Knibbe C.A.J. & Wildt S.N. (2021), The oral bioavailability and metabolism of midazolam in stable critically ill children: A pharmacokinetic microtracing study, Clinical Pharmacology & Therapeutics 109(1): 140-149.
- Goulooze S.C., Krekels E.H.J., Saleh M.A.A.E.W., Ahlers S.J., Valitalo P.A.J., Dongen E.P. van, Schaik R.H. van, Hankemeier T., Tibboel D. & Knibbe C.A.J. (2021), Predicting unacceptable pain in cardiac surgery patients receiving morphine maintenance and rescue doses: a model-based pharmacokinetic-pharmacodynamic analysis, Anesthesia and Analgesia 132(3): 726-734.
- Cristea S., Krekels E.H.J., Allegaert K., Paepe P. de, Jaeger A. de, Cock P. de & Knibbe C.A.J. (2021), Estimation of ontogeny functions for renal transporters using a combined population pharmacokinetic and physiology-based pharmacokinetic approach: application to OAT1,3, AAPS Journal 23(3): 65.
- Hoogd S. de, Goulooze S.C., Valkenburg A.J., Krekels E.H.J., Dijk M. van, Tibboel D. & Knibbe C.A.J. (2021), Postoperative breakthrough pain in paediatric cardiac surgery not reduced by increased morphine concentrations, Pediatric Research 90: 1201-1206.
- Goulooze S.C., Ista E., Dijk M. van, Tibboel D., Krekels E.H.J. & Knibbe C.A.J. (2021), Towards evidence-based weaning: a mechanism-based pharmacometric model to characterize iatrogenic withdrawal syndrome in critically ill children, AAPS Journal 23(4): 71.
- Keij F.M., Koch B.E.V., Lozano Vigario F., Simons S.H.P., Hasselt J.G.C. van, Knibbe C.A.J., Spaink H.P., Reiss I.K.M. & Krekels E.H.J. (2021), Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsis, Journal of Clinical and Translational Science 5(1): e140.
- Upadhyay P., Vet N.J., Goulooze S.C., Krekels E.H.J., Wildt S.N. de & Knibbe C.A.J. (2021), Midazolam infusion and disease severity affect the level of sedation in children: a parametric time-to-event analysis, Pharmaceutical Research 38: 1711-1720.
- Hartman S., Upadhyay P., Hagedoorn N., Krekels E.H.J., Mathot R., Moll H., Flier M. van der, Schreuder M., Bruggemann R., Knibbe C.A.J. & Wildt S. de (2021), Population pharmacokinetics of ceftriaxone in critically ill children, Critical Care Medicine 49(1): 425.
- Goulooze S.C., Kluis T. de, Dijk M. van, Ceelie I., Wildt S.N. de, Tibboel D., Krekels E.H.J. & Knibbe C.A.J. (2021), Quantifying the pharmacodynamics of morphine in the treatment of postoperative pain in preverbal children, The Journal of Clinical Pharmacology 62(1): 99-109.
- Jurado-Fasoli L., Di X.Y., Kohler I., Osuna-Prieto F.J., Hankemeier T., Krekels E.H.J., Harms A.C., Yang W., Garcia-Lario J.V., Fernendez-Veledo S., Ruiz J.R., Rensen P.C.N. & Martinez-Tellez B. (2021), Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults, Obesity 30(1): 50-61.
- Goulooze S.C., Zwep L.B., Vogt J.E., Krekels E.H.J., Hankemeier T., Anker J.N. van den & Knibbe C.A.J. (2020), Beyond the randomized clinical trial: innovative data science to close the pediatric evidence gap, Clinical Pharmacology & Therapeutics 107(4): 786-795.
- Wijk R.C. van, Sar A.M. van der, Krekels E.H.J., Verboom T., Spaink H.P., Simonsson U.S.H. & Graaf P.H. van der (2020), Quantification of natural growth of two strains of Mycobacterium marinum for translational anti‐tuberculosis drug development, Clinical and Translational Science 13(6): 1060-1064.
- Valkenburg A.J., Goulooze S.C., Ng C.Y., Breatnach C.V., Tibboel D., Dijk M. van, Knibbe C.A.J. & Krekels E.H.J. (2020), Exploring the relationship between morphine concentration and oversedation in children after cardiac surgery, The Journal of Clinical Pharmacology 60(9): 1231-1236.
- Michalickova D., Pokorna P., Tibboel D., Slanar O. Knibbe C.A.J. & Krekels E.H.J. (2020), Rapid increase in clearance of phenobarbital in neonates on extracorporeal membrane oxygenation: A pilot retrospective population pharmacokinetic analysis, Pediatric Critical Care Medicine 21(9): E707-E715.
- Cristea S., Krekels E.H.J., Rostami-Hodjegan A., Allegaert K. & Knibbe C.A.J. (2020), The influence of drug properties and ontogeny of transporters on pediatric renal clearance through glomerular filtration and active secretion: a simulation-based study, AAPS Journal 22(4): 87.
- Cristea S., Krekels E.H.J., Allegaert K. & Knibbe C.A.J. (2020), The predictive value of glomerular filtration rate-based scaling of pediatric clearance and doses for drugs eliminated by glomerular filtration with varying protein-binding properties, Clinical Pharmacokinetics 59: 1291-1301.
- Wijk R.C. van, Hu W.B., Dijkema S.M., Berg D. van den, Liu J., Bahi R., Verbeek F.J., Simonsson U.S.H., Spaink H.P., Graaf P.H. van der & Krekels E.H.J. (2020), Anti-tuberculosis effect of isoniazid scales accurately from zebrafish to humans, British Journal of Pharmacology 177(24): 5518-5533.
- Michalickova D., Jansa P., Bursova M., Hlozek T., Cabala R., Hartinger J.M., Ambroz D., Aschermann M., Lindner J., Linhart A., Slanar O. & Krekels E.H.J. (2020), Population pharmacokinetics of riociguat and its metabolite in patients with chronic thromboembolic pulmonary hypertension from routine clinical practice, Pulmonary Circulation 10(1): 1-11.
- Chen L., Krekels E.H.J., Verweij P.E., Buil J.B., Knibbe C.A.J. & Brüggemann R.J.M. (2020), Pharmacokinetics and pharmacodynamics of posaconazole, Drugs 80(7): 671-695.
- Krekels E.H.J., Calvier E.A.M., Graaf P.H. van der & Knibbe C.A.J. (2019), Children Are Not Small Adults, but Can We Treat Them As Such?, CPT: Pharmacometrics and Systems Pharmacology 8(1): 34-38.
- Wijk R.C. van, Krekels E.H.J., Kantae V., Harms A.C., Hankemeier T., Graaf P.H. van der & Spaink H.P. (2019), Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae, Scientific Reports 9: 2149.
- Wijk R.C. van, Krekels E.H.J., Kantae V., Ordas A., Kreling T., Harms A.C., Hankemeier T., Spaink H.P. & Graaf P.H. van der (2019), Mechanistic and quantitative understanding of pharmacokinetics in zebrafish larvae through nanoscale blood sampling and metabolite modelling of paracetamol, Journal of Pharmacology and Experimental Therapeutics 371(1): 15-24.
- Kleiber N., Calvier E., Mooij M.G., Krekels E.H.J., Vaes W.H.J., Tibboel D., Knibbe C.A.J. & Wildt S.N. de (2019), Enteral acetaminophen bioavailability in pediatric intensive care patients determined with an oral microtracer and pharmacokinetic modeling to pptimize dosing, Critical Care Medicine 47(12): e975-e983.
- Brussee J.M., Krekels E.H.J., Calvier E.A.M., Palic S., Rostami-Hodjegan A., Danhof M., Barrett J.S., Wildt S.N. de & Knibbe C.A.J. (2019), A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children, AAPS Journal 21(5): 81.
- Groen B.D. van, Vaes W.H., Park B.K., Krekels E.H.J., Duijn E. van, Körgvee L.-T., Maruszak W., Grynkiewicz G., Garner R.C., Knibbe C.A.J., Tibboel D., Wildt S.N. de & Turner M.A. (2019), Dose‐linearity of the pharmacokinetics of an intravenous [14C]midazolam microdose in children, British Journal of Clinical Pharmacology 85(10): 2332-2340.
- Cristea S., Allegaert K., Falcao A.C., Falcao F., Silva R., Smits A., Knibbe C.A.J. & Krekels E.H.J. (2019), Larger Dose Reductions of Vancomycin Required in Neonates with Patent Ductus Arteriosus Receiving Indomethacin versus Ibuprofen, Antimicrobial Agents and Chemotherapy 63(8): e00853.
- Calvier E.A.M., Krekels E.H.J., Johnson T.N., Rostami-Hodjegan A., Tibboel D. & Knibbe C.A.J. (2019), Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method, AAPS Journal 21(3): 38.
- Mian R., Valkenburg A.J., Allegaert K., Koch B.C.P., Breatnach C.V., Knibbe C.A.J., Tibboel D. & Krekels E.H.J. (2019), Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass, The Journal of Clinical Pharmacology 59(6): 847-855.
- Russo F.M., Mian P., Krekels E.H., Calsteren K. van, Tibboel D., Deprest J. & Allegaert K. (2019), Pregnancy affects the pharmacokinetics of sildenafil and its metabolite in the rabbit, Xenobiotica 49(1): 98-105.
- Goulooze S.C., Ista E., Dijk M. van, Hankemeier T., Tibboel D., Knibbe C.A.J. & Krekels E.H.J. (2019), Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms, CPT: Pharmacometrics and Systems Pharmacology 8(12): 904-912.
- Krekels E.H.J. & Knibbe C.A.J. (2019), Pharmacokinetics and pharmacodynamics of drugs in obese pediatric patients: how to map uncharted clinical territories. In: Kiess W., Schwab M. & Anker J. van den (red.), Pediatric Pharmacotherapy . Handbook of Experimental Pharmacology nr. 261. Cham: Springer. 231-255.
- Goulooze S.C., Völler S., Valitalo P.A.J., Calvier E.A.M., Aarons L., Krekels E.H.J. & Knibbe C.A.J. (2019), The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models, Clinical Pharmacokinetics 58(1): 131-138.
- Goulooze S.C., Krekels E.H.J., Hankemeier T. & Knibbe C.A.J. (2019), Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools, AAPS Journal 21: 11.
- Brussee J.M., Vet N.J., Krekels E.H.J., Valkenburg A.J., Jacqz-Aigrain E., Gerven J.M.A. van, Swart E.L., Anker J.N. van den, Tibboel D., Hoog M. de, Wildt S.N. de & Knibbe C.A.J. (2018), Predicting CYP3A-mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure, British Journal of Clinical Pharmacology 84(2): 358-368.
- Goulooze S.C., Välitalo P.A.J., Knibbe C.A.J. & Krekels E.H.J. (2018), Kernel-Based Visual Hazard Comparison (kbVHC): a Simulation-Free Diagnostic for Parametric Repeated Time-to-Event Models, AAPS Journal 20(1): 5.
- Calvier E.A.M., Krekels E.H.J., Yu H., Välitalo P.A.J., Johnson T.N., Rostami-Hodjegan A., Tibboel D., Graaf P.H. van der, Danhof M. & Knibbe C.A.J. (2018), Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments, CPT: Pharmacometrics and Systems Pharmacology 7(3): 175-185.
- Schulthess P., Wijk R.C. van, Krekels E.H.J., Yates J.W.T., Spaink H.P. & Graaf P.H. van der (2018), Outside-in systems pharmacology combines innovative computational methods with high-throughput whole vertebrate studies, CPT: Pharmacometrics and Systems Pharmacology 7(5): 285-287.
- Calvier E.A.M., Thu T.N., Johnson T.N., Rostami-Hodjegan A., Tibboel D., Krekels E.H.J. & Knibbe C.A.J. (2018), Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory, Pharmaceutical Research 35(11): 209.
- Brussee J.M., Yu H., Krekels E.H.J., Palic S., Brill M.J.E., Barrett J.S., Rostami-Hodjegan A., Wildt S.N. de & Knibbe C.A.J. (2018), Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach, Pharmaceutical Research 35: 182.
- Brussee J.M., Yu H., Krekels E.H.J., Roos B. de, Brill M.J.E., Anker J.N. van den, Rostami-Hodjegan A., Wildt S.N. de & Knibbe C.A.J. (2018), First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates, CPT: Pharmacometrics and Systems Pharmacology 7(6): 374-383.
- Zeilmaker G.A., Pokorna P., Mian P., Wildschut E.D., Knibbe C.A.J., Krekels E.H.J., Allegaert K. & Tibboel D. (2018), Pharmacokinetic considerations for pediatric patients receiving analgesia in the intensive care unit; targeting postoperative, ECMO and hypothermia patients, Expert Opinion on Drug Metabolism & Toxicology 14(4): 417-428.
- Kantae V., Krekels E.H.J., Esdonk M.J. van, Lindenburg P.W., Harms A.C., Knibbe C.A.J., Graaf P.H. van der & Hankemeier T. (2017), Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy, Metabolomics 13(1): 9.
- Calvier E.A.M., Krekels E.H.J., Välitalo P.A.J., Rostami-Hodjegan A., Tibboel D., Danhof M. & Knibbe C.A.J. (2017), Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?, Clinical Pharmacokinetics 56(3): 273-285.
- Wijk R.C. van, Krekels E.H.J., Hankemeier T., Spaink H.P. & Graaf P.H. van der (2017), Systems pharmacology of hepatic metabolism in zebrafish larvae, Drug Discovery Today: Disease Models 22: 27-34.
- Kantae V., Krekels E.H.J., Esdonk M.J. van, Lindenburg P.W., Harms A.C., Knibbe C.A.J., Graaf P.H. van der & Hankemeier T. (2017), Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy: an addition to the topical collection "Recent Advances in Pharmacometabolomics: Enabling Tools for Precision Medicine", Metabolomics 13(5): 58.
- Goulooze S.C., Krekels E.H.J., Dijk M. van, Tibboel D., Graaf P.H. van der, Hankemeier T., Knibbe C.A.J. & Hasselt J.G.C. van (2017), Towards personalized treatment of pain using a quantitative systems pharmacology approach, European Journal of Pharmaceutical Sciences 109: S32-S38.
- Guo Y., Wijk R.C. van, Krekels E.H.J., Spaink H.P., Graaf P.H. van der & Verbeek F.J. (2017), Multi-modal 3D reconstruction and measurements of zebrafish larvae and its organs using axial-view microscopy, 2017 IEEE International conference on image processing (ICIP). IEEE International Conference on Image Processing 2017 17 september 2017 - 20 september 2017: IEEE Xplore. 2194-2198.
- Krekels E.H.J., Hasselt J.G.C. van, Anker J.N. van den, Allegaert K., Tibboel D. & Knibbe C.A.J. (2017), Evidence-based drug treatment for special patient populations through model-based approaches, European Journal of Pharmaceutical Sciences 109(Supplement): S22-S26.
- Valitalo P.A.J., Krekels E.H.J., Dijk M. van, Simons S.H.P., Tibboel D. & Knibbe C.A.J. (2017), Morphine Pharmacodynamics in Mechanically Ventilated Preterm Neonates Undergoing Endotracheal Suctioning, CPT: Pharmacometrics and Systems Pharmacology 6(4): 239-248.
- Kantae V., Krekels E.H.J., Ordas A.K., Gonzalez O., Wijk R.C. van, Harms A.C., Racz P.I., Graaf P.H. van der, Spaink H.P. & Hankemeier T. (2016), Pharmacokinetic modeling of paracetamol uptake and clearance in zebrafish larvae: expanding the allometric scale in vertebrates with five orders of magnitude, Zebrafish 13(6): 504-510.
- Valkenburg A.J, Calvier E.A.M., Dijk M. van, Krekels E.H.J., O'Hare B.P., Casey W.F., Mathôt R.A., Knibbe C.A.J, Tibboel D. & Breatnach C.V. (2016), Pharmacodynamics and Pharmacokinetics of morphine after cardiac surgery in children with and without Down Syndrome, Pediatric Critical Care Medicine 17(10): 930-938.
- Krekels E.H., Niebecker R., Karlsson M.O., Miller R., Shimizu T., Karlsson K.E., Ruff C.T., Simonsson U.S. & Jönsson S. (2016), Population Pharmacokinetics of Edoxaban in Patients with Non-Valvular Atrial Fibrillation in the ENGAGE AF-TIMI 48 Study, a Phase III Clinical Trial, Clinical Pharmacokinetics 55(9): 1079-1090.
- Brussee J.M., Calvier E.A., Krekels E.H.J., Välitalo P.A.J., Tibboel D., Allegaert K. & Knibbe C.A. (2016), Children in clinical trials: towards evidence-based pediatric pharmacotherapy using pharmacokinetic-pharmacodynamic modeling, Expert review of clinical pharmacology 9(9): 1235-1244.
- Välitalo P.A., Dijk M. van, Krekels E.H.J., Gibbins S., Simons S.H., Tibboel D. & Knibbe C.A.J. (2016), Pain and distress caused by endotracheal suctioning in neonates is better quantified by behavioural than physiological items: a comparison based on item response theory modelling, Pain 157(8): 1611-1617.
- Novakovic A.M., Krekels E.H., Munafo A., Ueckert S. & Karlsson M.O. (2016), Application of Item Response Theory to Modeling of Expanded Disability Status Scale in Multiple Sclerosis, AAPS Journal 19: 172.
- Niebecker R., Jönsson S., Karlsson M.O., Miller R., Nyberg J., Krekels E.H.J. & Simonsson U.S. (2015), Population pharmacokinetics of edoxaban in patients with symptomatic deep-vein thrombosis and/or pulmonary embolism-the Hokusai-VTE phase 3 study, British Journal of Clinical Pharmacology 80(6): 1374-1387.
- Krekels E.H.J., Tibboel D. & Knibbe C.A.J. (2015), Pediatric pharmacology: current efforts and future goals to improve clinical practice, Expert Opinion on Drug Metabolism & Toxicology 11(11): 1679-1682.
- Krekels E.H.J., Ham S. van, Allegaert K., Hoon J. de, Tibboel D., Danhof M. & Knibbe C.A.J. (2015), Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants, European Journal of Clinical Pharmacology 71(9): 1075-82.
- Spaink H., Racz P., Ordas A., Veneman W., Vijver M., Wildwater M., Pieters R., Zope H.R., Kros A., Kantae V., Krekels E., Graaf P.H. van der & Hankemeier T. (2015), Automated zebrafish toxicology screening: effect assessment and uptake studies, Toxicology Letters 238(2): S54-S54.
- Krekels E.H.J., Knibbe C.A.J., Pokorna P. & Tibboel D. (2015), How to Translate Pharmacokinetic Data into Dosing Recommendations. In: Mimouni F.B. & Anker J.N. van den (red.), Neonatal Pharmacology and Nutrition Update nr. 18. Basel: Karger. 13-27.
- Krekels E.H.J., Tibboel D., Wildt S.N. de, Ceelie I., Dahan A., Dijk M. van, Danhof M. & Knibbe C.A.J. (2014), Evidence-based morphine dosing for postoperative neonates and infants, Clinical Pharmacokinetics 53(6): 553-563.
- Wang C., Sadhavisvam S., Krekels E.H.J., Dahan A., Tibboel D., Danhof M., Vinks A.A. & Knibbe C.A.J. (2013), Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model, Clinical Drug Investigation 33(7): 523-534.
- Krekels E.H.J., Johnson T.N., Hoedt S.M. den, Rostami-Hodjegan A., Danhof M., Tibboel D. & Knibbe C.A.J. (2012), From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II-Sensitivity to Physiological and Physicochemical Properties, CPT: Pharmacometrics and Systems Pharmacology 2012(1): e10.
- Krekels E.H.J., Neely M., Panoilia E., Tibboel D., Capparelli E., Danhof M., Mirochnick M. & Knibbe C.A.J. (2012), From pediatric covariate model to semiphysiological function for maturation: part I-extrapolation of a covariate model from morphine to Zidovudine, CPT: Pharmacometrics and Systems Pharmacology 2012(1): e9.
- Wang C., Peeters M.Y., Allegaert K., Blussé van Oud-Alblas H.J., Krekels E.H.J., Tibboel D., Danhof M. & Knibbe C.A.J. (2012), A bodyweight-dependent allometric exponent for scaling clearance across the human life-span, 29(6): 1570-1581.
- Krekels E.H.J. (10 oktober 2012), Size does matter : drug glucuronidation in children (Dissertatie, Faculty of Science, Leiden University). Promotor(en): Knibbe C.A.J. & Tibboel D.
- Krekels E.H.J., Danhof M., Tibboel D. & Knibbe C.A.J. (2012), Ontogeny of hepatic glucuronidation; methods and results, Current Drug Metabolism 13(6): 728-743.
- Sadhasivam S., Krekels E.H.J., Chidambaran V., Esslinger H.R., Ngamprasertwong P., Zhang K., Fukuda T. & Vinks A.A. (2012), Morphine clearance in children: does race or genetics matter?, Journal of Opioid Management 8(4): 217-226.
- Krekels E.H.J., Tibboel D. & Knibbe C.A.J. (2012), Prediction of morphine clearance in the paediatric population : how accurate are the available pharmacokinetic models?, Clinical Pharmacokinetics 51(11): 695-709.
- Knibbe C.A., Krekels E.H. & Danhof M. (2011), Advances in paediatric pharmacokinetics, Expert Opinion on Drug Metabolism & Toxicology 7(1): 1-8.
- Cock R.F.W. de, Piana C., Krekels E.H.J., Danhof M., Allegaert K. & Knibbe C.A.J. (2011), The role of population PK-PD modelling in paediatric clinical research, European Journal of Clinical Pharmacology 67(Suppl 1): 5-16.
- Krekels E.H.J., Angesjö M., Sjögren I., Möller K.A., Berge O.G. & Visser S.A. (2011), Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats, 28(7): 1561-1576.
- Krekels E.H.J., Hasselt J.G.C. van, Tibboel D., Danhof M. & Knibbe C.A.J. (2011), Systematic evaluation of the descriptive and predictive performance of paediatric morphine population models, Pharmaceutical Research 28(4): 797-811.
- Krekels E.H., DeJongh J., Van Lingen R.A., Van der Marel C.D., Choonara I., Lynn A.M., Danhof M., Tibboel D. & Knibbe C.A. (2011), Predictive performance of a recently developed population pharmacokinetic model for morphine and its metabolites in new datasets of (preterm) neonates, infants and children, Clinical Pharmacokinetics 50(1): 51-63.
- Steeg T.J. van, Krekels E.H.J., Freijer J., Danhof M. & Lange E.C.M. de (2010), Effect of altered AGP plasma binding on heart rate changes by S(-)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (K(B,vivo)), JOURNAL OF PHARMACEUTICAL SCIENCES 99(5): 2511-2520.
- Steeg T.J. van, Boralli V.B., Krekels E.H.J., Slijkerman P., Freijer J., Danhof M. & Lange E.C.M. de (2009), Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach, JOURNAL OF PHARMACEUTICAL SCIENCES 98(10): 3816-28.
- Knibbe C.A.J., Krekels E.H.J., Anker J.N. van den, DeJongh J., Santen G.W., Dijk M. van, Simons S.H., Lingen R.A. van, Jacqz-Aigrain E.M., Danhof M. & Tibboel D. (2009), Morphine glucuronidation in preterm neonates, infants and children younger than 3 years, Clinical Pharmacokinetics 48(6): 371-385.
- Krekels E.H.J., Anker J.N. van der, Baiardi P., Cella M., Cheng K.Y., Gibb D.M., Green H., Iolascon A., Jacqz-Aigrain E.M., Knibbe C.A.J., Santen G.W., Schaik R.H. van, Tibboel D. & Della Pasqua O.E. (2007), Pharmacogenetics and paediatric drug development: issues and consequences to labelling and dosing recommendations, Expert Opinion on Pharmacotherapy 8(12): 1787-1799.
- Steeg T.J. van, Krekels E.H.J., Danhof M. & Lange E.C.M. de (2007), Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats, Journal of Pharmacological and Toxicological Methods 56(1): 72-78.
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