Miranda van Eck
Scientific director / professor of Cardiovascular and metabolic therapeutics
- Name
- Prof.dr. M. van Eck
- Telephone
- +31 71 527 6238
- eck_m@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0003-3936-3194
Prof. Dr. Miranda van Eck is professor of Cardiovascular and metabolic therapeutics at the Division of BioTherapeutics, and Programme Director for the MSc programme of Bio-Pharmaceutical Sciences.
More information about Miranda van Eck
PhD Candidates
News
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Miranda van Eck new Scientific Director of the LACDR institute -
Education that connects to market needs: new course for master’s students focuses on quality in drug development -
How we can improve collaboration at LBSP, according to Miranda van Eck -
Faculty of Science kicks off the Academic Year with a vibrant talk show -
Twenty lecturers awarded Senior Teaching Qualification -
Four years of women's network at the Faculty of Science -
Altering the appearance of macrophages to prevent atherosclerosis -
Public Event International Day of Women & Girls in Science -
Miranda van Eck inaugural lecture: detergent tablets for clean, fat-free blood vessels
In the spotlight
Biography
Prof. Dr. Van Eck studied Biopharmaceutical Sciences, specializing in Biopharmaceutics at the University of Leiden. After her graduation in 1994, she obtained her PhD from Leiden University in 1999. In 2001, Van Eck was appointed as Research Fellow of the Netherlands Heart Foundation. In 2005, she obtained a prestigious VIDI Award and became appointed as Assistant Professor. In 2007, Van Eck was appointed Established Investigator of the Netherlands Heart Foundation and became Associate Professor. Her research is focused upon the role of macrophage genes in the development of atherosclerosis with special emphasis on the function of genes involved in HDL metabolism and reverse cholesterol transport from the arterial wall to the liver. For her work she received twice a Pfizer International HDL Research Award.
Scientific director / professor of Cardiovascular and metabolic therapeutics
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Pharmacology
- Hoekstra M. & Eck M. van (2024), Gene editing for the treatment of hypercholesterolemia, Current Atherosclerosis Reports 26: 139-146.
- Hoekstra M., Jong L.M. de, Geest R. van der, Leeuw L.R. de, Krinamurthi R., Geerling J.J. & Eck M. van (2024), LXR Agonist T0901317′s hepatic impact overrules its atheroprotective action in macrophages, driving early atherogenesis in cow-diet-fed male apolipoprotein E knockout mice, Biomolecules 14(4): 429.
- Hoekstra M., Snip O.S.C., Janusz P., Bernabé Kleijn M.N.A., Truitt E.R., Sullivan B.D., Schmidt T.A., Jay G.D. & Eck M. van (2024), Recombinant human proteoglycan 4 lowers inflammation and atherosclerosis susceptibility in female low-density lipoprotein receptor knockout mice, Journal of Physiology London 602(9): 1939-1951.
- Hoekstra M., Zhang Z., Lindenburg P.W. & Eck M. van (2024), Scavenger receptor BI deficiency in mice is associated with plasma ceramide and sphingomyelin accumulation and a reduced cholesteryl ester fatty acid length and unsaturation degree, Journal of Lipid and Atherosclerosis 13(1): 69-79.
- Goossens P., Rodriguez-Vita J., Etzerodt A., Masse M., Rastoin O., Gouirand V., Eck M. van, Ulas T., Papantonopoulou O., Bebien M., Turner M., Phong Vu Manh T., Dalod M., Auphan-Anezin N., Schultze J.L. & Lawrence T. (2024), Tumor-Induced Cholesterol Efflux from Macrophages Drives IL-4 Mediated Reprogramming and Tumor Progression, Cell Metabolism : .
- Verwilligen R.A.F., Mulder L., Araujo P.M., Carneiro M., Bussmann J., Hoekstra M. & Eck M. van (2023), Zebrafish as outgroup model to study evolution of scavenger receptor class B type I functions, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1868(6): 159308.
- Hoekstra M. & Eck M. van (2023), High-density lipoproteins and non-alcoholic fatty liver disease, Atherosclerosis Plus 53: 33-41.
- Sluis R.J. van der, Aardweg T. van den, Sijsenaar T.J.P., Eck M. van & Hoekstra M. (2023), Metyrapone treatment protects low-density lipoprotein receptor knockout mice against hypercorticosteronemia development without changing atherosclerosis susceptibility, Biomolecules 13(9): 1287.
- Hoekstra M., Eck M. van & Berkel T.J.C. van (2023), Perspective : hepatocyte-directed base editing as novel treatment for human dyslipidemia-current status and remaining challenges, Arteriosclerosis, Thrombosis, and Vascular Biology 43(6): 832-835.
- Zhang Y., Verwilligen R.A.F., Eck M. van & Hoekstra M. (2023), PRMT5 inhibition induces pro-inflammatory macrophage polarization and increased hepatic triglyceride levels without affecting atherosclerosis in mice, Journal of Cellular and Molecular Medicine 27(8): 1056-1068.
- Zhao Y., Zhang L., Liu L., Zhou X., Ding F., Yang Y., Du S., Wang H., Eck M. van & Wang J. (2022), Specific loss of ABCA1 (ATP-Binding Cassette Transporter A1) suppresses TCR (T-Cell Receptor) signaling and provides protection against atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology 42(12): e311-e326.
- Hoekstra M., Wel E.J. van der & Eck M. van (2022), Atherosclerosis regression is associated with both infiltration of new leukocytes into the plaque and a shift in macrophage polarization towards a more migratory phenotype, Atherosclerosis 356: 50-52.
- Jong L.M. de, Zhang Z., Hartog Y. de, Sijsenaar T.J.P., Martins Cardoso R., Manson M.L., Hankemeier T., Lindenburg P.W., Salvatori D.C.F., Eck M. van & Hoekstra M. (2022), PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice, Scientific Reports 12(1): 483.
- Verwilligen R.A.F., Mulder L., Rodenburg F.J., Dijke A. van, Hoekstra M., Bussmann J. & Eck M. van (2022), Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish, Atherosclerosis 346: 18-25.
- Hoekstra M., Liu Q., Zhang Y.H., Wel E.J. van der, Le Devedec S.E. & Eck M. van (2022), Hypocholesterolemic phospholipid transfer protein knockout mice exhibit a normal glucocorticoid response to food deprivation, American Journal of Translational Research 14(3): 1884-1891.
- Snip O.S.C., Hoekstra M., Zhang Y., Geerling J.J. & Eck M. van (2022), 2-Hydroxypropyl-beta-cyclodextrin treatment does not induce atherosclerotic lesion regression in Western-type diet-fed apolipoprotein E knockout mice, Biomolecules 12(9): 1205.
- Ouweneel A.B., Reiche M.E., Snip O.S.C., Wever R., Wel E.J. van der, Schaftenaar F.H., Kauerova S., Lutgens E., Eck M. van & Hoekstra M. (2022), Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis, Journal of Cell Science 135(5): jcs.258901.
- Korporaal S.J.A., Sluis R.J. van der, Eck M. van & Hoekstra M. (2021), Bone marrow Ts65Dn trisomy-induced changes in platelet functionality and lymphocytopenia do not impact atherosclerosis susceptibility in mice, Journal of Cardiovascular Development and Disease 8(9): 110.
- Hoekstra M., Ren B., Laurila P.P., Hildebrand R.B., Soronen J., Frodermann V., Li Z., Boon M.R., Geerling J.J., Rensen P.C.N., Jauhiainen M. & Eck M. van (2021), Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice, Scientific Reports 11: 16419.
- Hommes J.W., Kratofil R.M., Wahlen S., Haas C.J.C. de, Hildebrand R.B., Hovingh G.K., Otto M., Eck M. van, Hoekstra M., Korporaal S.J.A. & Surewaard B.G.J. (2021), High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins, Scientific Reports 11: 15357.
- Ouweneel A.B., Zhao Y., Calpe-Berdiel L., Lammers B., Hoekstra M., Berkel T.J.C. van & Eck M. van (2021), Impact of bone marrow ATP-binding cassette transporter A1 deficiency on atherogenesis is independent of the presence of the low-density lipoprotein receptor, Atherosclerosis 319: 79-85.
- Zhang Y., Boer M. de, Wel E.J. van der, Eck M. van & Hoekstra M. (2021), PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867(11): 166212.
- Ouweneel A.B., Reiche M.E., Snip O.S.C., Wever R., Wel E.J. van der, Schaftenaar F.H. & Kauerova S.: Lutgens E.: Eck M. van Hoekstra M. (2021), Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis, Journal of Cell Science 135(5): jcs258901.
- Zhang Y., Verwilligen R.A.F., Boer M. de, Sijsenaar T.J.P., Eck M. van & Hoekstra M. (2021), PRMT4 inhibitor TP-064 impacts both inflammatory and metabolic processes without changing the susceptibility for early atherosclerotic lesions in male apolipoprotein E knockout mice, Atherosclerosis 338: 23-29.
- Martins Cardoso R., Creemers E., Absalah S., Hoekstra M., Gooris G.S., Bouwstra J.A. & Eck M. van (2020), Hyperalphalipoproteinemic scavenger receptor BI knockout mice exhibit a disrupted epidermal lipid barrier, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865(3): 158592.
- Hoekstra M., Sluis R.J. van der, Hildebrand R.B., Lammers B., Zhao Y., Praticò D., Berkel T.J.C. van, Rensen P.C.N., Kooijman S., Jauhiainen M. & Eck M. van (2020), Disruption of PLTP (phospholipid transfer protein)-mediated HDL (high-density lipoprotein) maturation reduces SR-BI (scavenger receptor BI) deficiency-driven atherosclerosis susceptibility despite unexpected metabolic complications, Arteriosclerosis, Thrombosis, and Vascular Biology 40(3): 611-623.
- Hoekstra M. & Eck M. van (2020), Correspondence to Probucol-induced hypocholesterolemia is not associated with exacerbated foam cell formation in ABCG1 knockout mice, Atherosclerosis 296: 91-92.
- Benne N., Martins Cardoso R., Boyle A.L., Kros A., Jiskoot W., Kuiper J., Bouwstra J., Eck M. van & Slütter B.A. (2020), Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques, Advanced Healthcare Materials 9(10): 2000043.
- Martins Cardoso M., Absalah S., Eck M. van & Bouwstra J.A. (2020), Barrier lipid composition and response to plasma lipids: A direct comparison of mouse dorsal back and ear skin, Experimental Dermatology 29(6): 548-555.
- Hoekstra M., Ouweneel A.B., Price J., Geest R. van der, Sluis R.J. van der, Geerling J.J., Nahon J.E. & Eck M. van (2020), SR-BI deficiency disassociates obesity from hepatic steatosis and glucose intolerance development in high fat diet-fed mice, Journal of Nutritional Biochemistry 89: 108564.
- Sluis R.J. van der, Depuydt M.A.C., Eck M. van & Hoekstra M. (2020), VLDL/LDL serves as the primary source of cholesterol in the adrenal glucocorticoid response to food deprivation, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865(7): 158682.
- Verwilligen R.A.F., Bussmann J. & Eck M. van (2020), Zebrafish atherosclerosis: experimental definitions and difficulties, Atherosclerosis 302: 52-54.
- Hoekstra M., Nahon J.E., Jong L.M. de, Kröner M.J., Leeuw L.R. de & Eck M. van (2019), Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865(6): 1402-1409.
- Cardoso R.M., Creemers E., Absalah S., Gooris G.S., Hoekstra M., Eck M. van & Bouwstra J.A. (2019), Hypercholesterolemia in young adult APOE−/− mice alters epidermal lipid composition and impairs barrier function, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864(7): 976-984.
- Ouweneel A.B., Verwilligen R.A.F. & Eck M. van (2019), Vulnerable plaque and vulnerable blood: Two critical factors for spontaneous atherothrombosis in mouse models, Atherosclerosis 284: 160-164.
- Goossens P., Rodriguez-Vita J., Etzerodt A., Masse M., Rastoin O., Gouirand V., Ulas T., Papantonopoulou O., Eck M. van, Auphan-Anezin N., Bebien M., Verthuy C., Vu Manh T.P., Turner M., Dalod M., Lawrence T. & Schultze J.L. (2019), Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression, Cell Metabolism 29(6): 1376-1389.
- Sluis R.J. van der, Depuydt M.A.C., Verwilligen R.A.F., Hoekstra M. & Eck M. van (2019), Elimination of adrenocortical apolipoprotein E production does not impact glucocorticoid output in wild-type mice, Molecular and Cellular Endocrinology 490: 21-27.
- Hoekstra M., Snip O.S.C. & Eck M. van (2019), Letter by Hoekstra et al Regarding Article, "Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages", Circulation 139(16): 1981-1982.
- Geest R. van der, Sluis R.J. van der, Groen A.K., Eck M. van & Hoekstra M. (2019), Cholestasis-associated glucocorticoid overexposure does not increase atherogenesis, Journal of Endocrinology 242(2): 1-12.
- Snip O.S.C., Ouweneel A.B., Wever R., Schaftenaar F.H., Cejkova S., Eck M. van & Hoekstra M. (2019), Apolipoprotein A1 modulates the ability of bone marrow to facilitate lymphocyte production after transplantation into Ldl receptor knockout mice, Atherosclerosis 287: E107-E107.
- Hoekstra M., Ouweneel A.B., Nahon J.E., Geerling J.J. & Eck M. van (2019), Sr-Bi deficiency uncouples the development of hypertriglyceridemia and atherosclerosis from hepatic steatosis aand glucose intolerance in obese mice, Atherosclerosis 287: E121-E121.
- Verwilligen R.A.F., Dijke A. van, Hoekstra M., Bussmann J. & Eck M. van (2019), The role of endothelial and macrophage scavenger receptor stabilin 1 and 2 in early atherosclerosis development in zebrafish, Atherosclerosis 287: E101-E102.
- Hoekstra M., Ouweneel A.B., Nahon J.E., Geest R. van der, Kröner M.J., Sluis R.J. van der & Eck M. van (2019), ATP-binding cassette transporter G1 deficiency is associated with mild glucocorticoid insufficiency in mice, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864(4): 443-451.
- Nahon J.E., Hoekstra M., Harmelen V. van, Rensen P.C.N., Willems Van Dijk K., Kooijman S. & Eck M. van (2019), Proteoglycan 4 deficiency protects against glucose intolerance and fatty liver disease in diet-induced obese mice, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865(2): 494-501.
- Houde M. & Eck M. van (2018), Escaping the atherogenic trap: Preventing LDL fusion and binding in the intima, Atherosclerosis 275: 376-378.
- Nahon J.E., Groeneveldt C., Geerling J.J., Eck M. van & Hoekstra M. (2018), Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor-driven transcription of hepatic lipogenic genes in vivo, British Journal of Pharmacology 175(15): 3175-3183.
- Nahon J.E., Hoekstra M., Havik S.R., Santbrink P.J. van., Dallinga-Thie G.M., Kuivenhoven J.A., Geerling J.J. & Eck M. van (2018), Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model, Atherosclerosis 274: 120-127.
- Madsen M., Hansen P.R., Nielsen L.B., Martins Cardoso R., Eck M. van. & Pedersen T.X. (2018), Imiquimod-Induced Psoriasis-Like Skin Lesions Do Not Accelerate Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice, The American Journal of Pathology 88(6): 1486-1496.
- Nahon J.E., Hoekstra M., Havik S.R., Santbrink P.J. van, Dallinga-Thie G.M., Kuivenhoven J.A., Geerling J.J. & Eck M. van (2018), Corrigendum to "Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model", Atherosclerosis 279: 132-132.
- Sluis R.J. van der, Verwilligen R.A.F., Lendvai Z., Wever R., Hoekstra M. & Eck M. van (2018), HDL is essential for atherosclerotic lesion regression in Apoe knockout mice by bone marrow Apoe reconstitution, Atherosclerosis 278: 240-249.
- Ouweneel A.B., Hoekstra M., Wel E.J. van der, Schaftenaar F.H., Snip O.S.C., Hassan J., Korporaal S.J.A. & Eck M. van (2018), Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice, Atherosclerosis 282: 176-182.
- Heestermans M., Ouweneel A.B., Hassan J., Kloosterman M., Reitsma P.H., Gijbels M.J.J., Vlijmen B.J.M. van & Eck M. van (2018), Predilection of Low Protein C-induced Spontaneous Atherothrombosis for the Right Coronary Sinus in Apolipoprotein E deficient mice, Scientific Reports 8(1): 15106.
- Nahon J.E., Hoekstra M. & Eck M. van (2018), Total body proteoglycan 4 (Prg4) deficiency increases atherosclerosis susceptibility in apolipoprotein E knockout and low-density lipoprotein receptor knockout mice, Atherosclerosis 278: 315-316.
- Nahon J.E., Hoekstra M., Hulst S. van, Manta C., Goerdt S., Geerling J.J., Géraud C. & Eck M. van (2018), Hematopoietic Stabilin-1 deficiency does not influence atherosclerosis susceptibility in LDL receptor knockout mice, Atherosclerosis 281: 47-55.
- Snip O.S.C., Hoekstra M., Zhao Y., Calpe-Berdiel L., Vulve J., Carles Escola-Gil J., Foks A., Sluis R.J. van der, Blanco-Vaca F., Berkel T.J.C. van, Kuivenhoven J. & Eck M. van (2018), Reduced systemic inflammation and increased reverse cholesterol transport together drive leukocyte ABCA1-mediated protection against atherosclerosis, Atherosclerosis 275: e43-e44.
- Hoekstra M., Geerling J.J., Jiskoot W. & Eck M. van (2018), The Anti-atherogenic Potential of Liposome-mediated Delivery of LXR Agonists to Macrophages: a Preclinical Validation Study, Atherosclerosis Supplements 32: 7.
- Nahon J.E., Groeneveldt C., Eck M. van & Hoekstra M. (2018), Inhibition of PRMT3 activity selectively prevents LXR-driven transcription of hepatic lipogenic genes in vivo , Atherosclerosis Supplements 32: 36-36.
- Nahon J., Hoekstra M., Kooijman S. & Eck M. van (2018), PRG4 KO mice are protected from high fat diet-induced metabolic disruptions , Atherosclerosis Supplements 32: 36-37.
- Ren B., Kampen E.E.M. van, Berkel T.J.C. van, Cruickshank S.M. & Eck M. van (2017), Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis, Atherosclerosis 256: 35-46.
- Vorst E.P.C. van der, Kosta T., Wu Y., Hoeksema M.A., Goossens P., Bursill C.A., Aliyev T., Huitema L.F.A., Tas S.W., Wolfs I.M.J., Kuijpers M.J.E., Gijbels M.J., Schalkwijk C.G., Koonen D.P.Y., Abdollahi-Roodsaz S., McDaniels K., Wang C.-C., Leitges M., Lawrence T., Plat J., Eck M. van, Rye K.-A., Touqui L., Winther M.P.J. de, Biessen E.A.L. & Donners M.M.P.C. (2017), High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-kappa B/STAT1-IRF1 Signaling, Cell Metabolism 25(1): 197-207.
- Ouweneel A.B., Heestermans M., Verwilligen R.A.F., Gijbels M.J.J., Reitsma P.H., Eck M. van & Vlijmen B.J.M. van (2017), Silencing of Anticoagulant Protein C Evokes Low-Incident but Spontaneous Atherothrombosis in Apolipoprotein E-Deficient Mice-Brief Report, Arteriosclerosis, Thrombosis, and Vascular Biology 37(5): 782-785.
- Ouweneel A.B., Sluis R.J. van der, Nahon J.E., Eck M. van & Hoekstra M. (2017), Simvastatin treatment aggravates the glucocorticoid insufficiency associated with hypocholesterolemia in mice, Atherosclerosis 261: 99-104.
- Snip O.S.C., Geerling J.J. & Eck M. van (2017), Leukocyte ABCA1 impedes progression of established atherosclerotic lesions after dietary cholesterol lowering in LDLr-/- mice, Atherosclerosis 263: E1.
- Geest R. van der, Ouweneel A.B., Sluis R.J. van der, Groen A.K., Eck M. van & Hoekstra M. (2016), Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice, Toxicology and Applied Pharmacology 306: 1-7.
- Hoekstra M. & Eck M. van (2016), HDL is redundant for adrenal steroidogenesis in LDLR knockout mice with a human-like lipoprotein profile, Journal of Lipid Research 57(4): 631-637.
- Louwe M.C., Lammers B., Frias M.A., Foks A.C., Leeuw L.R. de., Hildebrand R.B., Kuiper J., Smit J.W.A., Berkel T.J.C. van, James R.W., Geerling J.J., Rensen P.C.N. & Eck M. van (2016), ABCA1 deficiency protects the heart against myocardial infarction-induced injury, Atherosclerosis 251: 159-163.
- Brinck J.W., Thomas A., Lauer E., Jornayvaz F.R., Brulhart-Meynet M-C., Prost J-C., Pataky Z., Lofgren P., Hoffstedt J., Eriksson M., Pramfalk C., Morel S., Kwak B.R., Eck M. van, James R.W. & Frias Miguel A. (2016), Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection, Arteriosclerosis, Thrombosis, and Vascular Biology 36(5): 817-824.
- Vorst E.P.C. van der, Theodorou K., Hoeksema M.A., Wu Y., Goossens P., Eck M. van, Rye K-A., Winther M.P.J. de, Biessen E.A.L. & Donners M.M.P. (2016), High density lipoproteins exert pro-inflammatory effects on macrophages via passive cholesterol depletion and PKC-NF-kB/STAT1-IRF1 signaling, Cardiovascular Research 111(suppl_1): S10-S10.
- Vorst E. van der, Theodorou K., Wu Y., Hoeksema M., Goossens P., Bursill C., Huitema L., Tas S., Gijbels M., McDaniels K., Wang C.C., Leitges M., Lawrence T., Touqui L., Plat J., Eck M. van, Rye K.A., Winther M. de, Biessen E. & Donners M. (2016), High density lipoproteins exert pro-inflammatory effects on macrophages via passive cholesterol depletion and PKC-NF-kb/stat1-irf1 signaling, Atherosclerosis 252: E108-E109.
- Ouweneel A.B. & Eck M. van (2016), Lipoproteins as modulators of atherothrombosis: From endothelial function to primary and secondary coagulation, Vascular Pharmacology 82: 1-10.
- Ouweneel A.B., Heestermans M., Verwilligen R.A.F., Eck M. van & Vlijmen B.J.M. van (2016), Silencing anticoagulant protein c causes spontaneous atherothrombosis in ApoE knockout mice, Atherosclerosis 252: E26.
- Laurila P.-P., Soronen J., Kooijman S., Forsstrom S., Boon M.R., Surakka I., Kaiharju E., Coomans C.P., Berg S.A.A. van den, Autio A., Sarin A.-P., Kettunen J., Tikkanen E., Manninen T., Metso J., Silvennoinen R., Merikanto K., Ruuth M., Perttila J., Makela A., Isomi A., Tuomainen A.M., Tikka A., Ramadan U.A., Seppala I., Lehtimaki T., Erilcsson J., Havulinna A., Jula A., Karhunen P.J., Salomaa V., Perola M., Ehnholm C., Lee-Rueckert M., Eck M. van, Roivainen A., Taskinen M.-R., Peltonen L., Mervaala E., Jalanko A., Hohtola E., Olkkonen V.M., Ripatti S., Kovanen P.T., Rensen P.C.N., Suomalainen A. & Jauhiainenit M. (2016), USF1 deficiency activates brown adipose tissue and improves cardiometabolic health, Science Translational Medicine 8(323): 323ra13.
- Kooijman S., Meurs I., Van der Stoep M., Habets K.L., Lammers B., Berbee J.F.P., Havekes L.M., Van Eck M., Romijn J.A., Korporaal S.J.A. & Rensen P.C.N. (2015), Hematopoietic alpha 7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis, Journal of Thrombosis and Haemostasis 13(1): 126-135.
- Van Kampen Erik, Jaminon Armand, Van Berkel Theo J.C. & Van Eck Miranda (2014), Diet-induced (epigenetic) changes in bone marrow augment atherosclerosis, Journal of Leukocyte Biology 96(5): 833-841.
- Kampen E. van, Beaslas O., Hildebrand R.B., Lammers B., Berkel T.J.C. van, Olkkonen V.M. & Eck M. van (2014), Orp8 Deficiency in Bone Marrow-Derived Cells Reduces Atherosclerotic Lesion Progression in LDL Receptor Knockout Mice, PLoS ONE 9(10): e109024.
- Vorst E.P.C. van der, Theodorou K., Plat J., Eck M. van, Rye K.A., Bursill C.A., Tas S.W., Winther M.P.J. de, Biessen E.A.L. & Donners M.M.P.C. (2014), High density lipoproteins exert pro-inflammatory effects on macrophages via IKK2-and NIK-independent NF-kB activation, Cardiovascular Research 103: S2.
- Maiwald S., Sivapalaratnam S., Motazacker M.M., Capelleveen J.C. van, Bot I., Jager S.C. de, Eck M. van, Jolley J., Kuiper J., Stephens J., Albers C.A., Vosmeer C.R., Kruize H., Geerke D.P., Wal A.C. van der, Loos C.M. van der, Kastelein J.J., Trip M.D., Ouwehand W.H., Dallinga-Thie G.M. & Hovingh G.K. (2014), Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis, PLoS ONE 9(5): e98289.
- Eck Miranda van (2014), ATP-binding cassette transporter A1: key player in cardiovascular and metabolic disease at local and systemic level, 25(4): 297-303.
- Olivier Maryline, Bott Romain, Frisdal Eric, Nowicki Marion, Plengpanich Wanee, Desmarchelier Charles, Roi Stephanie, Quinn C.M., Gelissen Ingrid, Jessup Wendy, Van Eck Miranda, Guerin Maryse, Le Goff Wilfried & Reboul Emmanuelle (2014), ABCG1 is involved in vitamin E efflux, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841(12): 1741-1751.
- Van der Sluis Ronald J., Van den Aardweg Tim, Reuwer Anne Q., Twickler Marcel T., Boutillon Florence, Van Eck Miranda, Goffin Vincent & Hoekstra Menno (2014), Prolactin receptor antagonism uncouples lipids from atherosclerosis susceptibility, Journal of Endocrinology 222(3): 341-350.
- Van der Stoep Marco, Korporaal Suzanne J.A. & Van Eck Miranda (2014), High-density lipoprotein as a modulator of platelet and coagulation responses, 103(3): 362-371.
- Khedoe P.P., Wong M.C., Wagenaar G.T., Plomp J.J., Van Eck M., Havekes L.M., Rensen P.C., Hiemstra P.S. & Berbee J.F. (2013), The effect of PPE-induced emphysema and chronic LPS-induced plmonary inflammation on atherosclerosis development in APOE*3-LEIDEN mice, 8(11): e80196.
- Hoekstra M., Sluis R.J. van der, Eck M. van & Berkel T.J.C. van (2013), Adrenal-Specific Scavenger Receptor BI Deficiency Induces Glucocorticoid Insufficiency and Lowers Plasma Very-Low-Density and Low-Density Lipprotein Levels in Mice, Arteriosclerosis, Thrombosis, and Vascular Biology 33(2): e39-46.
- Hoekstra Menno, Korporaal Suzanne J.A., Van der Sluis Ronald J., Hirsch-Reinshagen Veronica, Bochem Andrea E., Wellington Cheryl L., Van Berkel Theo J.C., Kuivenhoven Jan Albert & Van Eck Miranda (2013), LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function, 54(2): 358-364.
- Van der Stoep Marco, Li Zhaosha, Calpe-Berdiel Laura, Van der Sluis Ronald J., Saleh Peshtiwan, McKinnon Heather J., Smit Martin J., Korporaal Suzanne J.A., Van Berkel Theo J.C., Van Eck Miranda & Hoekstra Menno (2013), Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development, Biochemical Pharmacology 86(11): 1594-1602.
- Stoep M. van der, Li Z., Calpe-Berdiel L., Sluis R.J. van der, McKinnon H.J., Smit M.J., Berkel T.J.C. van, Van Eck M., Hoekstra M. & Korporaal S.J.A. (2013), Liver X receptor (LXR) agonist T0901317 induces regression of early and advanced atherosclerotic lesions under normolipidemic conditions in mice: PB 1.32-1, Journal of Thrombosis and Haemostasis 11(s2): 520-520.
- Korporaal S.J.A., Angelis V. de, Hoekstra M., Gitz E., Bochem A.E., Sjouke B., Hovingh K., Groot P.G. de & Eck M. van (2013), Disturbed glycoprotein VI-mediated signaling in platelets from hypercholesterolemic mice and humans, Journal of Thrombosis and Haemostasis 11: 280-280.
- Stoep M. van der, Li Z., Sluis R.J. van der, Berkel T.J.C. van, Eck M. van, Hoekstra M. & Korporaal S.J.A. (2013), Liver X receptor (LXR) activation influences murine platelet count only under normolipidemic conditions, Journal of Thrombosis and Haemostasis 11: 910-910.
- Gautier Thomas, De Haan Willeke, Grober Jacques, Ye Dan, Bahr Matthias J., Claudel Thierry, Nijstad Niels, Van Berkel Theo J.C., Havekes Louis M., Manns Michael P., Willems Stefan M., Hogendoorn Pancras C.W., Lagrost Laurent, Kuipers Folkert, Van Eck Miranda, Rensen Patrick C.N. & Tietge Uwe J.F. (2013), Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice, 54(8): 2195-2205.
- Korporaal S.J.A., De Angelis V., Sjouke B., Van der Stoep M., Bochem A.E., Hovingh K., Groot P.G. de & Van Eck M. (2013), Plasma LDL-cholesterol lowering by LDL apheresis induces acute changes in platelet properties, Journal of Thrombosis and Haemostasis 11(S2): 773-773.
- Van Berkel T., Kuiper J. & Van Eck M. (2013), Macrophage cholesterol homeostasis and atherosclerosis, Cardiology 126: 199-199.
- Van Eck Miranda & Van Berkel Theo J.C. (2013), ATP-Binding Cassette Transporter A1 in Lipoprotein Metabolism and Atherosclerosis A New Piece of the Complex Puzzle, Arteriosclerosis, Thrombosis, and Vascular Biology 33(10): 2281-2283.
- Kunnen S. & Eck M. van (2012), Lecithin: cholesterol acyltransferase: old friend or foe in atherosclerosis?, 53(9): 1783-1799.
- Vrins C.L.J., Ottenhoff R., Oever K. van den, Waart D.R. de, Kruyt J.K., Zhao Y., Berkel T.J.C. van, Havekes L.M., Aerts J.M., Eck M. van, Rensen P.C.N. & Groen A.K. (2012), Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein, Journal of Lipid Research 53(10): 2017-2023.
- Calpe-Berdiel L., Zhao Y., Graauw M. de, Ye D., Santbrink P.J. van, Mommaas A.M., Foks A., Bot M., Meurs I., Kuiper J., Mack J.T., Eck M. van, Tew K.D. & Berkel T.J.C. van (2012), Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice, Atherosclerosis 223(2): 332-341.
- Olivier M., Tanck M.W., Out R., Villard E.F., Lammers B., Bouchareychas L., Frisdal E., Superville A., Berkel T. van, Kastelein J.J., Eck M. van, Jukema J.W., Chapman M.J., Dallinga-Thie G.M., Guerin M. & Goff W.L. (2012), Human ATP-Binding Cassette G1 Controls Macrophage Lipoprotein Lipase Bioavailability and Promotes Foam Cell Formation, Arteriosclerosis, Thrombosis, and Vascular Biology 32(9): 2223-2231.
- Calpe-Berdiel L., Zhao Y., Graauw M. de, Ye D., Santbrink P.J. van, Mommaas A.M., Foks A.C., Bot M., Meurs I., Kuiper J., Mack J.T., Eck M. van, Tew K.D. & Berkel T.J.C. van (2012), Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice, Atherosclerosis 223(2): 332-341.
- Meurs I., Lammers B., Zhao Y., Out R., Hildebrand R.B., Hoekstra M., Berkel T.J.C. van & Eck M. van (2012), The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis, Atherosclerosis 221(1): 41-47.
- Meurs I., Calpe-Berdiel L., Habets K.L.L., Zhao Y., Korporaal S.J.A., Mommaas A.M., Josselin E., Hildebrand R.B., Ye D., Out R., Kuiper J., Berkel T.J.C. van, Chimini G. & Eck M. van (2012), Effects of Deletion of Macrophage ABCA7 on Lipid Metabolism and the Development of Atherosclerosis in the Presence and Absence of ABCA1, PLoS ONE 7(3): e30984.
- Lammers B., Zhao Y., Foks A.C., Hildebrand R.B., Kuiper J., Berkel T.J. van & Eck M. van (2012), Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice, PLoS ONE 7(10): e48080.
- Hoekstra M., Eck M. van & Korporaal S.J.A. (2012), Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I, Current Opinion in Lipidology 23(2): 127-132.
- Li Z., Wang Y., Sluis R.J. van der, Hoorn J.W.A. van der, Princen H.M.G., Eck M. van, Berkel T.J.C. van, Rensen P.C.N. & Hoekstra M. (2012), Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice, Biochemical Pharmacology 84(6): 821-829.
- Foks A.C., Frodermann V., Ter Borg M., Habets K.L., Bot I., Zhao Y., Van Eck M., Van Berkel T.J., Kuiper J. & Van Puijvelde G.H. (2011), Differential effects of regulatory T cells on the initiation and regression of atherosclerosis, Atherosclerosis 218(1): 53-60.
- Zhao Y., Pennings M., Vrins C.L., Calpe-Berdiel L., Hoekstra M., Kruijt J.K., Ottenhoff R., Hildebrand R.B., Van der Sluis R., Jessup W., Le Goff W., Chapman M.J., Huby T., Groen A.K., Van Berkel T.J. & Van Eck M. (2011), Hypocholesterolemia, foam cell accumulation, but no atherosclerosis in mice lacking ABC-transporter A1 and scavenger receptor BI, Atherosclerosis 218(2): .
- Ye D., Zhao Y., Hildebrand R.B., Singaraja R.R., Hayden M.R., Berkel T.J.C. van & Eck M. van (2011), The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in LDL receptor knockout mice, The American Journal of Pathology 178(1): 413-422.
- Karuna R., Holleboom A.G., Motazacker M.M., Kuivenhoven J.A., Frikke-Schmidt R., Tybjaerg-Hansen A., Georgopoulos S., Eck M. van, Berkel T.J.C. van, Eckardstein A. von der & Rentsch K.M. (2011), Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism, Atherosclerosis 214(2): 448-455.
- Ye D., Lammers B., Zhao Y., Meurs I., Berkel T.J.C. van & Eck M. van (2011), ATP-binding cassette transporters A1 and G1, HDL metabolism, cholesterol efflux, and inflammation: important targets fro the treatment of atherosclerosis, Current Drug Targets 12(5): 647-660.
- Lammers B., Zhao Y., Hoekstra M., Hildebrand R.B., Ye D., Meurs I., Berkel T.J.C. van & Eck M. van (2011), Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1and ApoE, PLoS ONE 6(10): e26095.
- Nofer J.R. & Van Eck M. (2011), HDL scavenger receptor class B type I and platelet function, Current Opinion in Lipidology 22(4): .
- Zhao Y., Ye D., Wang J., Calpe-Berdiel L., Azzis S.B., Berkel T.J. van & Eck M. van (2011), Stage-Specific Remodeling of Atherosclerotic Lesions on Cholesterol Lowering in LDL Receptor Knockout Mice, The American Journal of Pathology 179(3): 1522-1532.
- Lammers B., Chandak P.G., Aflaki E., Puijvelde G.H.M. van, Radovic B., Hildebrand R.B., Meurs I., Out R., Kuiper J., Berkel T.J.C. van, Kolb D., Haemmerle G., Zechner R., Levak-Frank S., Eck M. van & Kratky D. (2011), Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in LDL receptor knockout mice, Arteriosclerosis, Thrombosis, and Vascular Biology 31(1): 67-73.
- Lammers B., Chandak P.G., Aflaki E., Puijvelde G.H.M. van, Radovic B., Hildebrand R.B., Meurs I., Out R., Kuiper J., Berkel T.J.C. van, Kolb D., Haemmerle G., Zechner R., Levak-Frank S., Eck M. van & Kratky D. (2011), Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice, Arteriosclerosis, Thrombosis, and Vascular Biology 31(1): 67-73.
- Brodde M.F., Korporaal S.J., Herminghaus G., Fobker M., Van Berkel T.J., Tietge U.J., Robenek H., Van Eck M., Kehrel B.E. & Nofer J.R. (2011), Native high-density lipoproteins inhibit platelet activation via scavenger receptor BI: role of negatively charged phospholipids, Atherosclerosis 215(2): .
- Vergeer M., Korporaal S.J., Franssen R., Meurs I. van, Out R., Hovingh G.K., Hoekstra M., Sierts J.A., Dallinga-Thie G.M., Motazacker M.M., Holleboom A.G., Van Berkel T.J., Kastelein J.J., Van Eck M. & Kuivenhoven J.A. (2011), Genetic variant of the scavenger receptor BI in humans, The New England Journal of Medicine 364(2): .
- Korporaal S.J.A., Meurs I., Hauer A.D., Hildebrand R.B., Hoekstra M., Ten Cate H., Pratico D., Akkerman J.W.N., Berkel T.J.C. van, Kuiper J. & Eck M. van (2011), Deletion of the HDL receptor SR-BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol, Arteriosclerosis, Thrombosis, and Vascular Biology 31(1): 34-42.
- Duwensee K., Schwaiger S., Tancevski I., Eller K., Eck M. van, Markt P., Linder T., Stanzl U., Ritsch A., Patsch J.R., Schuster D., Stuppner H., Bernhard D. & Eller P. (2011), Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein, Atherosclerosis 219(1): 109-115.
- Karuna R., Holleboom A.G., Motazacker M.M., Kuivenhoven J.A., Frikke-Schmidt R., Tybjaerg-Hansen A., Georgopoulos S., Van Eck M., Van Berkel T.J., Von Eckardstein A. & Rentsch K.M. (2010), Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism, Atherosclerosis 214(2): .
- Zhao Y., Van Berkel T.J. & Van Eck M. (2010), Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions, Current Opinion in Lipidology 21(5): .
- Ye D., Zhao Y., Hildebrand R.B., Singaraja R.R., Hayden M.R., Van Berkel T.J. & Van Eck M. (2010), The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice, The American Journal of Pathology 178(1): .
- Tancevski I., Demetz E., Eller P., Duwensee K., Hoefer J., Heim C., Stanzl U., Wehinger A., Auer K., Karer R., Huber J., Schgoer W., Eck M. van, Vanhoutte J., Fievet C., Stellaard F., Rudling M., Patsch J.R. & Ritsch A. (2010), The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice, PLoS ONE 5(1): e8722.
- Hoekstra M., Van Berkel T.J. & Van Eck M. (2010), Scavenger receptor BI: a multi-purpose player in cholesterol and steroid metabolism, World Journal of Gastroenterology 16(47): .
- Ye D., Meurs I. van, Ohigashi M., Calpe-Berdiel L., Habets K.L., Zhao Y., Kubo Y., Yamaguchi A., Van Berkel T.J., Nishi T. & Van Eck M. (2010), Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice, Biochemical and Biophysical Research Communications 395(3): .
- Hoekstra M., Korporaal S.J., Li Z., Zhao Y., Eck M. van & Berkel T.J. van (2010), Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice, AJP - Endocrinology and Metabolism 299(6): E1038-1043.
- Meurs I., Eck M. van & Berkel T.J.C. van (2010), Key Molecule in Cholesterol Efflux and the Prevention of Atherosclerosis, Current Pharmaceutical Design 16(13): 1445-1467.
- Hildebrand R.B., Lammers B., Meurs I., Korporaal S.J., De Haan W., Zhao Y., Kruijt J.K., Pratico D., Schimmel A.W., Holleboom A.G., Hoekstra M., Kuivenhoven J.A., Van Berkel T.J., Rensen P.C. & Van Eck M. (2010), Restoration of High-Density Lipoprotein Levels by Cholesteryl Ester Transfer Protein Expression in Scavenger Receptor Class B Type I (SR-BI) Knockout Mice Does not Normalize Pathologies Associated with SR-BI Deficiency, Arteriosclerosis, Thrombosis, and Vascular Biology 30(7): 1439-39.
- Hoekstra M., Li Z., Kruijt J.K., Van Eck M., Van Berkel T.J. & Kuiper J. (2010), The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status, Journal of Hepatology 52(2): .
- Zhao Y., Pennings M., Hildebrand R.B., Ye D., Calpe-Berdiel L., Out R., Kjerrulf M., Hurt-Camejo E., Groen A.K., Hoekstra M., Jessup W., Chimini G., Berkel T.J. van & Eck M. van (2010), Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-B1 in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet, Circulation Research 107(12): e20-e30.
- Hoekstra M., Ye D., Hildebrand R.B., Zhao Y., Lammers B., Stitzinger M., Kuiper J., Berkel T.J.C. van & Eck M. van (2009), Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production, Journal of Lipid Research 50(6): 1039-1046.
- Hoekstra M., Meurs I., Koenders M., Out R., Hildebrand R.B., Kruijt J.K., Eck M. van & Berkel T.J.C. van (2008), Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting, Journal of Lipid Research 49: 738-745.
- Velde A.E. van der, Vrins C., Oever K. van den, Seemann I., Oude Elferink R.P., Eck M. van, Kuipers F. & Groen A.K. (2008), Regulation of direct transintestinal cholesterol excretion in mice, American Journal of Physiology: Gastrointestinal and Liver Physiology : .
- Eck M. van, Hoekstra M., Out R., Ros I.X., Kruijt J.K., Hildebrand R.B. & Berkel T.J.C. van (2008), Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo, 49(1): 136-146.
- Out R., Jessup W., Goff L.J., Hoekstra M., Gelissen I.C., Zhao Y., Kritharides L., Chimini G., Kuiper J., Chapman M.J., Huby T., Berkel T.J.C. van & Eck M. van (2008), Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC, Circulation Research 102(1): 113-120.
- Guo J., Bot I., Nooijer R. de, Hoffman S.J., Stroup G.B., Biessen E.A.L., Benson G.M., Groot P.H., Eck M. van & Berkel T.J.C. van (2008), Leukocyte cathepsin K affects atherosclerotic lesion composition and bone mineral density in LDL-receptor deficient mice, Cardiovascular Research : .
- Ye D., Kraaijeveld A.O., Grauss R.W., Willems S.M., Vark-van der Zee L.C. van, Jager S.C.A. de, Jauhiainen M., Kuivenhoven J.A., Dalling-Thie G.M., Atsma D.E., Hogendoorn P.C., Biessen E.A.L., Berkel T.J.C. van, Jukema J.W. & Eck M. van (2008), Reduced leucocyte cholesteryl ester transfer protein expression in acute coronary syndromes, Journal of Internal Medicine 264(6): 571-585.
- Out R., Hoekstra M., Habets K.L., Meurs I., Waard V. de, Hildebrand R.B., Wang Y., Chimini G., Kuiper J., Berkel T.J.C. van & Eck M. van (2008), Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophagesand distinct atherosclerosis at relatively low plasma cholesterol levels, Arteriosclerosis, Thrombosis, and Vascular Biology 28(2): 258-264.
- Feng Y., Eck M. van, Craeyveld E. van, Jacobs F., Carlier V., Linthout S. van, Erdel M., Tjwa M. & Geest B. van der (2008), Critical role of scavenger receptor-BI expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer, Blood : .
- Herczenik E., Bouma B., Korporaal S.J.A., Strangi R., Zeng Q., Gros P., Eck M. van, Berkel T.J.C. van, Gebbink M.F. & Akkerman J.W. (2007), Activation of human platelets by misfolded proteins, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 1657-1665.
- Out R., Hoekstra M., Meurs I., Vos P. de, Kuiper J., Eck M. van & Berkel T.J.C. van (2007), Total body ABCG1 expression protects against early atherosclerotic lesion development in mice, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 594-599.
- Eck M. van, Hoekstra M., Hildebrand R.B., Yaong Y., Stengel D., Kruijt J.K., Sattler W., Tietge U.J., Ninio E., Berkel T.J.C. van & Praticò D. (2007), Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 2413-2419.
- Pennings M., Hildebrand R.B., Ye D., Kunne C., Berkel T.J.C. van, Groen A.K. & Eck M. van (2007), Bone marrow-derived multidrug resistance protein ABCB4 protects against atherosclerotic lesion development in LDL receptor knockout mice, Cardiovascular Research 76: 175-183.
- Korporaal S.J.A., Eck M. van, Adelmeijer J., Ijsseldijk M.J., Out R., Lisman T., Lenting P.J., Berkel T.J.C. van & Akkerman J.W. (2007), Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 2476-2483.
- Vikstedt R., Ye D., Metso J., Hildebrand R.B., Berkel T.J.C. van, Ehnholm C., Jauhiainen M. & Eck M. van (2007), Macrophage phospholipid transfer protein contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 578-586.
- Ye D., Hoekstra M., Out R., Meurs I., Kruijt J.K., Hildebrand R.B., Berkel T.J.C. van & Eck M. van (2007), Hepatic cell-specific atp-binding cassette (ABC) transporter profiling identifies putative novel candidates for macrophage cholesterol homeostasis in mice, Atherosclerosis Supplements 8(1): 24-24.
- Hoekstra M., Stitzinger M., Out R., Van Eck M., Van Berkel T.J. & Kuiper J. (2007), Nutrition-induced changes in adiponutrin gene expression implicate a role for adiponutrin in hepatic lipogenesis, Atherosclerosis Supplements 8(1): 211-211.
- Ginneken V.J.T. van, Verhey E., Poelmann R.E., Ramakers R., Willems van Dijk K., Ham L., Voshol P.J., Havekes L.M., Eck M. van & Greef J. van der (2007), Metabolomics (liver and blood profiling) in a mouse model in response to fasting: A study of hepatic steatosis, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1771: 1263-1270.
- Eck M. van, Singaraja R., Ye D., Hildebrand R.B., James E.R., Hayden M.R. & Berkel T.J.C. van (2006), Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice, Arteriosclerosis, Thrombosis, and Vascular Biology 26: 929-954.
- Pennings M., Meurs I., Ye D., Out R., Hoekstra M., Berkel T.J.C. van & Eck M. van (2006), Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development, 580: 5588-5596.
- Singaraja R., Eck M. van, Bissada N., Zimetti F., Collins H.L., Hildebrand RB, Hayden A., Brunham L.R., Kang M.H., Fruchart JC, Berkel T.J.C. van, Parks J.S., Staels B., Rothblat G.H., Fievet C. & Hayden M.R. (2006), Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo, Circulation 19: 1301-1309.
- Out R., Hoekstra M., Hildebrand RB, Kruit J.K., Meurs I., Li Z., Kuipers F., Berkel T.J.C. van & Eck M. van (2006), Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 26: 2295-2300.
- Hoekstra M., Stitzinger M., Wanrooij E.J.A. van, Michon I.N., Kruijt J.K., Kamphorst J.T., Eck M. van, Vreugdenhil E., Berkel T.J.C. van & Kuiper J. (2006), Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet, Journal of Lipid Research 47: 2198-2207.
- Burgess B.L., McIsaac S.A., Naus K.E., Chan J.Y., Tansley G.H., Yang J., Miao F., Ross C., Eck M. van, Hayden M.R., Nostrand W.E. van, St. George-Hyslop P., Westaway D. & Wellington C. (2006), Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma, Neurobiology of Disease 24: 114-1127.
- Vikstedt R., Ye D., Metso J, Hildebrand RB, Berkel T.J.C. van, Ehnholm C., Jauhiainen M. & Eck M. van (2006), Macrophage PLTP contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development, Arteriosclerosis, Thrombosis, and Vascular Biology : .
- Eck M. van, Oost J., Goudriaan J.R., Hoekstra M., Hildebrand M., Bos IST, Willems Van Dijk K. & Berkel T.J.C. van (2005), Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development, Atherosclerosis 83: 230-237.
- Out R., Hoekstra M., Jager S.C.A. de, Vos P. de, Westhuyzen D.R. van der, Webb N.R., Eck M. van, Biessen E.A.L. & Berkel T.J.C. van (2005), Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice, 46: 1172-1181.
- Berkel T.J.C. van, Out R., Hoekstra M., Kuiper J., Biessen E.A.L. & Eck M. van (2005), Scavenger receptors: friend or foe in atherosclerosis?, Current Opinion in Lipidology 16: 525-535.
- Hoekstra M., Out R., Kruijt J.K., Eck M. van & Berkel T.J.C. van (2005), Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells, Journal of Hepatology 42: 400-407.
- Guo J., Waard V. de, Eck M. van, Hildebrand RB, Wanrooij E.J.A. van, Kuiper J., Maeda N., Benson M.H., Groot P.H.E. & Berkel T.J.C. van (2005), Repopulation of apolipoprotein E knockout mice with CCR2-deficient progenitor cells does not inhibit ongoing atherosclerotic lesion development, Arteriosclerosis, Thrombosis, and Vascular Biology 25: 1014-1019.
- Tietge U.J., Pratico D., Ding T., Funk C.D., Hildebrand RB, Berkel T.J.C. van & Eck M. van (2005), Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress, 46: 1604-1614.
- Meurs I., Hoekstra M., Wanrooij E.J.A. van, Hildebrand RB, Kuiper J., Kuipers F., Hardeman M.R., Berkel T.J.C. van & Eck M. van (2005), HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes, Experimental Hematology 33: 1309-1319.
- Eck M. van, Pennings M., Hoekstra M., Out R. & Berkel T.J.C. van (2005), Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis, Current Opinion in Lipidology 16: 307-315.
- Combes B., Coltel N., Alibert M., Eck M. van, Raymond C. & Juhan-Vaque I. (2005), ABCA1 gene deletion protects against cerebral malaria: potential pathogenic role of microparticles in neuropathology, The American Journal of Pathology 166: 295-302.
- Guo J., Eck M. van, Waard V. de, Maeda N., Benson G.N., Groot P.H. & Berkel T.J.C. van (2005), The presence of leukocyte CC-chemokine receptor 2 in CCR2 knockout mice promotes atherogenesis, Biochimica et Biophysica Acta 1740: 543-459.
- Bot I., Guo J., Eck M. van, Santbrink P.J. van, Groot P.H., Hildebrand RB, Seppen J., Berkel T.J.C. van & Biessen E.A.L. (2005), Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo, Blood 106: 1147-1153.
- Berkel T. van, Out R., Hoekstra M., Hildebrand R.B., Kruijt K., Singaraja R., Kaminski W.E., Schmitz G., Hayden M. & Eck M. van (2005), W10 regulation of plasma HDL levels and metabolism, Atherosclerosis Supplements 6(1): 46-46.
- Garling E., Eck M. van, Wedding T., Veeger H.E.J., Valstar E.R. & Nelissen R.G.H.H. (2005), Increased muscle activity to stabilise mobile bearing knees in patients with rheumatoid arthritis, The Knee 12: 177-182.
- Out R., Hoekstra M., Spijkers J.A., Kruijt J.K., Eck M. van, Bos I.S.T., Twisk J. & Berkel T.J.C. van (2004), Scavenger receptor class B type I is solely reponsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice, 45: 2088-2095.
- Korporaal S.J.A., Relou I.A., Eck M. van, Strasser V., Bezemer M., Gorter G., Berkel T.J.C. van, Nimpf J., Akkerman J.W. & Lenting P.J. (2004), Binding of Low Density Lipoprotein to Platelet Apolipoprotein E Receptor 2' results in phosphorylation of p38MAPK, Journal of Biological Chemistry 279(50): 52526-52534.
- Eck M. van, Bos I.S., Hildebrand R.B., Rij B.T. & Berkel T.J.C. van (2004), Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development, The American Journal of Pathology 165: 785-794.
- Berkel T.J.C. van, Thüsen J.H. von der, Kuiper J., Biessen E. & Eck M. van (2004), Genetic manipulation of macrophage and vascular genes in mouse models of atherosclerosis, International Congress Series 1262: 384-387.
- Out R., Kruijt J.K., Rensen P.C.N., Hildebrand R.B., Vos P. de, Eck M. van & Berkel T.J.C. van (2004), Scavenger receptor BI plays a role in facilitating chylomicron metabolism, Journal of Biological Chemistry 279(18): 18401-18406.
- Guo J., Eck M. van, Twisk J., Maeda N., Benson G.N., Groot P.H. & Berkel T.J.C. van (2003), Transplantation of monocyte CC-chemokine receptor 2-deficient bone marrow into ApoE3-Leiden mice inhibits atherogenesis, Arteriosclerosis, Thrombosis, and Vascular Biology 23: 447-453.
- Hoen P.A.C. 't, Lans C. van der, Eck M. van, Bijsterbosch M.K., Berkel T.J.C. van & Twisk J. (2003), Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes, Circulation Research 93: 262-269.
- Eck M. van, Twisk J., Hoekstra M., Rij B.T., Lans C. van der, Bos I.S., Kruijt J.K., Kuipers F. & Berkel T.J.C. van (2003), Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver, Journal of Biological Chemistry 278(26): 23699-23705.
- Eck M. van, Twisk J., Rij B. van, Lans C. van der, Hoekstra M., Bos S., Kuipers F. & Berkel T.J.C. van (2002), Differential effects of scavenger receptor BI (SRBI) deficiency on the arterial wall and the liver, Circulation 106: II-77.
- Eck M. van, Bos I.S., Kaminski W.E., Orso E., Rothe G., Twisk J., Bottcher A., Amersfoort E.S. van, Christiansen-Weber T.A., Fung-Leung W.P., Berkel T.J.C. van & Schmitz G. (2002), Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues, 99: 6298-6303.
- Eck M. van, Bos S. & Berkel T.J.C. van (2002), Macrophage scavenger receptor B1 (SRBI) deficiency promotes atherosclerotic lesion development, Circulation 106: II-77.
- Vlijmen B.J.M. van, Gerritsen G, Franken AL, Boesten L.S.M., Kockx M.M., Gijbels M.J.J., Vierboom M.P.M., Eck M. van, Water B. van de, Berkel T.J.C. van & Havekes L.M. (2001), Macrophage p53 deficiency leads to enhanced atherosclerosis in ApoE*3-Leiden transgenic mice, Circulation Research 88(8): 780-786.
- Eck M. van, Herijgers N., Dijk K.W. van, Havekes A.M., Hofker M.H., Groot P.H. & Berkel T.J.C. van (2000), Effect of macrophage-derived mouse ApoE, human ApoE3, human ApoE2 (Arg155-Cys) on cholesterol levels and atherosclerosis in ApoE-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 20(1): 119-127.
- Eck-Smaling M.M. van, Winther M.P.J. de, Herijgers N., Havekes L.M., Hofker M.H., Groot P.H. & Berkel T.J.C. van (2000), Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in apoE-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 20: 2600-2606.
- Herijgers N., Winther M.P.J. de, Eck M. van, Havekes A.M., Hofker M.H., Koffeman L.J. & Berkel T.J.C. van (2000), Effect of human scavenger receptor class A oerexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice, 41(9): 1402-1409.
- Eck M. van, Zimmerman R., Zechner R., Groot P.H.E. & Berkel T.J.C. van (1998), Role of macrophage-derived LPL in lipoprotein metabolism, Circulation 98: I-663.
- Rensen P.C.N., Oosten M. van, Amersfoort E.S. van, Eck M. van, Kuiper J. & Berkel T.J.C. van (1998), Apolipoprotein E is increased by bacterial LPS in vivo and protects against LPS-induced lethality, Circulation 98: I-305.
- Herijgers N., Eck M. van, Korporaal S.J.A., Groot P.H.E., Hoogerbrugge P.M. & Berkel T.J.C. van (1998), Crucial role of the macrophage low density receptor (LDLr) in foam cell formation and the development of atherosclerosis, Circulation 98: I-385.
- Kuipers F., Jong M.C., Lin Y., Eck M. van, Havinga R., Bloks V., Verkade H.J., Hofker M.H., Moshage H., Berkel T.J.C. van, Vonk R.J. & Havekes L.M. (1998), Impaired secretion of very low density lipoprotein triglycerides by apolipoprotein E-deficient mouse hepatocytes, Journal of Clinical Investigation 100: 2915-2922.
- Kuipers F., Jong M.C., Lin Y.G., Eck M. van, Havinga R., Bloks V., Verkade H.J., Hofker M.H., Moshage H., Berkel T.J.C. van, Vonk R.J. & Havekes L.M. (1997), Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein e-deficient mouse hepatocytes, Journal of Clinical Investigation 100(11): 2915-2922.
- Berkel T.J.C. van, Eck M. van, Herijgers N., Hoogerbrugge P.M. & Groot P.H.E. (1997), Modulation of arteriosclerosis by gene therapy. In: Wall E. & et al. (Eds.), Vascular Medicine. Amsterdam: Kluwer. 197-218.
- Herijgers N., Eck M. van, Yates J.R.W., Pearce N.J., Hoogerbrugge P.M., Groot P.H.E. & Berkel T.J.C. van (1997), Bone marrow transplantation in Apoliprotein E-deficient mice: effect of ApoE gene-dosage on cholesterol, triglycerines, remnant catabolism and atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology 17: 1995-2003.
- Eck M. van, Herijgers N., Vidgeon-Hart M., Pearce N.J., Hoogerbrugge P.M., Groot P.H.E. & Berkel T.J.C. van (1997), Bone marrow transplantation in Apolipoprotein E-deficient mice: effect of ApoE gene-dosage on serum lipid concentrations, beta-VLDL catabolism and artherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology 17: 3117-3126.
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