Natalia Ortiz Zacarias
Onderzoeker
- Naam
- Dr. N.V. Ortiz Zacarias Ph.D.
- Telefoon
- +31 71 527 2727
- n.v.ortiz.zacarias@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0001-7470-5546
Onderzoeker
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal Chemistry
- Wagner S., Moura Gatti F., Silva D.G. de, Ortiz Zacarias N.V., Zweemer A.J.M., Hermann S., Maria M. de, Koch M., Weiss C., Schepmann D., Heitman L.H., Tschammer N., Kopka K. & Junker A. (2021), Development of the first potential nonpeptidic positron emission tomography tracer for the imaging of CCR2 receptors, ChemMedChem 16(4): 640-645.
- Ortiz Zacarías N.V., Chahal K.K., Šimková T., Horst C. van der, Zheng Y., Inoue A., Theunissen E., Mallee L., Es D. van der, Louvel J., IJzerman A.P., Handel T.M., Kufareva I. & Heitman L.H. (2021), Design and characterization of an intracellular covalent ligand for CC chemokine receptor 2, Journal of Medicinal Chemistry 64(5): 2608-2621.
- Ortiz Zacarías N.V., Bemelmans M.P., Handel T.M., Visser K.E. de & Heitman L.H. (2021), Anticancer opportunities at every stage of chemokine function, Trends in Pharmacological Sciences 42(11): 912-928.
- Patberg M., Isaak A., Füsser F., Ortiz Zacarías N.V., Vinnenberg L., Schulte J., Michetti L., Grey L., Horst C. van der, Hundehege P., Koch O., Heitman L.H., Budde T. & Junker A. (2021), Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists, European Journal of Medicinal Chemistry 226: 113838.
- Sommer F., Ortiz Zacarías N.V., Heitman L.H. & Meijer A.H. (2020), Inhibition of macrophage migration in zebrafish larvae demonstrates in vivo efficacy of human CCR2 inhibitors, Developmental and Comparative Immunology 116: 103932.
- Ortiz Zacarías N.V. (4 december 2019), The road to Insurmountability: Novel avenues to better target CC Chemokine Receptors (Dissertatie. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University). Promotor(en): IJzerman A. & Heitman L.
- Ortiz Zacarías N.V., Veldhoven J.P.D. van, Hollander L.S. den, Dogan B., Openy J., Hsiao Y.Y., Lenselink E.B., Heitman L.H. & IJzerman A.P. (2019), Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5, Journal of Medicinal Chemistry 62(24): 11035-11053.
- Ortiz Zacarías N.V., Lenselink E.B., IJzerman A.P., Handel T.M. & Heitman L.H. (2018), Intracellular Receptor Modulation: Novel Approach to Target GPCRs, Trends in Pharmacological Sciences 39(6): 547-559.
- Zacarias N.V.O., Veldhoven J.P.D. van, Portner L., Spronsen E. van, Ullo S, Veenhuizen M., Velden W.J.C. van der, Zweemer A.J.M., Kreekel R.M., Oenema K., Lenselink E.B., Heitman L.H.I & IJzerman A.P. (2018), Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2, Journal of Medicinal Chemistry 61(20): 9146-9161.
- Bot I., Ortiz Zacarias N.V., Witte W.E. de, Vries H. de, Santbrink P.J. van, Velden D. van der, Kroener M.J., Berg D.J. van den, Stamos D., Lange E.C.M. de, Kuiper J., IJzerman A.P. & Heitman L.H. (2017), A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy, Scientific Reports 2017(7): 52.
- Thum S., Kokornaczyk A.K., Seki T., De Maria M., Ortiz Zacarias N.V., Vries H. de, Weiss C., Koch M.l., Schepmann D., Kitamura M., Tschammer N., Heitman L.H., Junker A. & Wuensch B. (2017), Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold, European Journal of Medicinal Chemistry 135: 401-413.
- Zheng Y., Qin L., Ortiz Zacarias N.V., Vries H. de, Han G.W., Gustavsson M., Dabros M., Zhao C., Cherney R.J., Carter P., Stamos D., Abagyan R., Cherezov V., Stevens R.C., IJzerman A.P., Heitman L.H., Tebben A., Kufareva I. & Handel T.M. (2016), Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists, Nature 540(7633): 458-461.
- Massink A., Gutiérrez-de-Terán H., Lenselink E.B., Ortiz Zacarías N.V., Xia L., Heitman L.H., Katritch V., Stevens R.C. & IJzerman A.P. (2015), Sodium Ion Binding Pocket Mutations and Adenosine A2A Receptor Function, Molecular Pharmacology 87(2): 305-13.