Ferry Ossendorp
Hoogleraar Moleculair gedefinieerde vaccinbiologie
- Naam
- Prof.dr. F.A. Ossendorp
- Telefoon
- +31 71 526 3800
- f.a.ossendorp@lumc.nl
- ORCID iD
- null
Ferry A. Ossendorp is hoogleraar Moleculaire Vaccinbiologie en hoofd van de Tumor Immunologie groep op de afdeling Immunologie van het Leids Universitair Medisch Centrum. Hij is ook lid van de Wetenschappelijke Raad van KWF Kankerbestrijding.
Moleculaire vaccin biologie en Tumor immunologie
Immuuntherapie heeft in de strijd tegen kanker een stevige plaats geworven naast de klassieke chemo- en radiatietherapieën. De waarneming dat het immuunsysteem ook maligne cellen kan aanvallen en de groei van kanker kan remmen is al lang bekend maar de cellulaire en moleculaire mechanismes zijn pas de laatste decaden duidelijk geworden. Moleculair ontwerp van kanker-specifieke vaccins met moderne kennis is een centraal onderzoeksthema. Therapeutische vaccinatie heeft als groot voordeel dat de geïnduceerde afweerreactie selectief tumoren aanvalt en de gezonde cellen onaangetast laat. In theorie dus de ideale therapie zonder heftige bijwerkingen. Het huidige onderzoek richt zich op beter begrip van de vaccinatie mechanismes en op mogelijkheden om het suppressieve milieu in de tumoren te beïnvloeden zodat immuuntherapie effectief kan werken. Hiertoe worden nieuwe combinatietherapieën in detail onderzocht.
Wetenschappelijke carrière
Ferry Ossendorp heeft Biologie gestudeerd op de Universiteit van Amsterdam en zijn promotieonderzoek gedaan aan het Nederlands Kanker Instituut in Amsterdam. Dit leidde tot promotie aan de Universiteit van Amsterdam. De titel van zijn proefschrift (1989) was: "Thyroid antigens and monoclonal antibodies in a thyroid tumor model". Vervolgens werd postdoc onderzoek gedaan aan de rol van T cel functies in kanker aan het Nederlands Kanker Instituut. Zijn carrière werd voortgezet als senior onderzoeker op een zelf verworven KWF project in het Academisch Ziekenhuis Leiden in 1993. Vanaf 1996 werd hij wetenschappelijk staflid op de afdeling Immunohematologie en Bloedtransfusie (nu Immunologie) op het Leids Universitair Medisch Centrum. In 2001 werd hij Universitair Docent en in 2005 Universitair Hoofddocent. Hij werd in November 2010 benoemd als hoogleraar Moleculair gedefinieerde Vaccinbiologie bij de faculteiten Geneeskunde en Wiskunde en Natuurwetenschappen. De titel van zijn oratie is: ”Op de juiste knopjes drukken”.
Al meer dan 25 jaar doet Ferry Ossendorp onderzoek naar het immuunsysteem en kanker en is nu hoofd van de Tumor Immunologie groep. Fundamenteel onderzoek naar het T cel immuunsysteem in verschillende facetten is centraal in zijn groep. Studies naar antigeen opname, processing en presentatie aan T cellen, de biologie van dendritische cellen en de regulatie van de immuniteit staan te doel om de afweerreacties tegen tumorcellen beter te begrijpen en immuuntherapie van kanker te verbeteren. Recent zijn onderzoeksresultaten uit het laboratorium en in proefdieren vertaalt in een vroege klinische studie waarin kankerpatienten worden ingespoten met een experimenteel tumor-specifiek peptide-conjugaat vaccin.
Prijzen en eervolle benoemingen
Ferry Ossendorp heeft persoonlijke subsidies verkregen bij NWO TOP (2011), CTMM (2011) en de Amerikaanse Cancer Research Institute CRI (2015). In 2016 werd de Leiden University Translational Drug Discovery & Development “Molecule to Man” Award verkregen met het doel patient-specifieke kanker immunotherapie te ontwikkelen.
Hoogleraar Moleculair gedefinieerde vaccinbiologie
- Faculteit Geneeskunde
- Divisie 4
- Immunologie
- IHB Tumorimmunologie
- Gu, Z.L.; Hao, Y.; Schomann, T.; Ossendorp, F.; Dijke, P. ten & Cruz, L.J. (2023), Enhancing anti-tumor immunity through liposomal oxaliplatin and localized immunotherapy via STING activation, Journal of Controlled Release 357: 531-544.
- Gu, Z.L.; Silva, C.G. da; Hao, Y.; Schomann, T.; Camps, M.G.M.; Maaden, K. van der; Liu, Q.; Ossendorp, F. & Cruz, L.J. (2023), Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer, Journal of Controlled Release 353: 490-506.
- Speetjens, F.M.; Welters, M.J.P.; Slingerland, M.; Poelgeest, M.I.E. van; Steenwijk, P.J.D. van; Roozen, I.; Boekestijn, S.; Loof, N.M.; Zom, G.G.; Valentijn, A.R.P.M.; Krebber, W.J.; Meeuwenoord, N.J.; Janssen, C.A.H.; Melief, C.J.M.; Marel, G.A. van der; Filippov, D.V.; Burg, S.H. van der; Gelderblom, H. & Ossendorp, F. (2022), Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions, Journal for ImmunoTherapy of Cancer 10(10).
- Pardieck, I.N.; Duikeren, S. van; Veerkamp, D.M.B.; Brasem, D.J.; Redeker, A.; Bergen, J. van; Han, W.D.; Ossendorp, F.; Zondag, G. & Arens, R. (2022), Dominant antiviral CD8(+) T cell responses empower prophylactic antibody-eliciting vaccines against cytomegalovirus, Frontiers in Immunology 13.
- Pardieck, I.N.; Sluis, T.C. van der; Gracht, E.T.I. van der; Veerkamp, D.M.B.; Behr, F.M.; Duikeren, S. van; Beyrend, G.; Rip, J.; Nadafi, R.; Nejad, E.B.; Mulling, N.; Brasem, D.J.; Camps, M.G.M.; Myeni, S.K.; Bredenbeek, P.J.; Kikkert, M.; Kim, Y.; Cicin-Sain, L.; Abdelaal, T.; Gisbergen, K.P.J.M. van; Franken, K.L.M.C.; Drijfhout, J.W.; Melief, C.J.M.; Zondag, G.C.M.; Ossendorp, F. & Arens, R. (2022), A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection, Nature Communications 13(1).
- Arakelian, T.; Oosterhuis, K.; Tondini, E.; , M. los; Vree, J.; Geldorp, M. van; Camps, M.; Teunisse, B.; Zoutendijk, I.; Arens, R.; Zondag, G.; Ossendorp, F. & Bergen, J. van (2022), Pyroptosis-inducing active caspase-1 as a genetic adjuvant in anti-cancer DNA vaccination, Vaccine 40(13): 2087-2098.
- in't Veld, R.V.H.; Lara, P.; Jager, M.J.; Koning, R.I.; Ossendorp, F. & Cruz, L.J. (2022), M1-derived extracellular vesicles enhance photodynamic therapy and promote immunological memory in preclinical models of colon cancer, JOURNAL OF NANOBIOTECHNOLOGY 20(1).
- Tondini, E.; Reintjens, N.R.M.; Castello, G.; Arakelian, T.; Isendoorn, M.; Camps, M.; Vree, J.; Marel, G.A. van der; Filippov, D.V.; Codee, J.D.C. & Ossendorp, F. (2022), Lipid A analog CRX-527 conjugated to synthetic peptides enhances vaccination efficacy and tumor control, npj Vaccines 7(1).
- Yu, Z.F.; Vepris, O.; Eich, C.; Feng, Y.S.; Que, I.; Camps, M.G.M.; Zhang, H.; Ossendorp, F.A. & Cruz, L.J. (2022), Upconversion nanoparticle platform for efficient dendritic cell antigen delivery and simultaneous tracking, Microchimica Acta 189(10).
- Chung, C.K.; Beekmann, U.; Kralisch, D.; Bierau, K.; Chan, A.; Ossendorp, F. & Cruz, L.J. (2022), Bacterial cellulose as drug delivery system for optimizing release of immune checkpoint blocking antibodies, Pharmaceutics 14(7).
- Hos, B.J.; Tondini, E.; Camps, M.G.M.; Rademaker, W.; Bulk, J. van den; Ruano, D.; Janssen, G.M.C.; Ru, A.H. de; Elsen, P.J. van den; Miranda, N.F.C.C. de; Veelen, P.A. van & Ossendorp, F. (2022), Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA, Cell Reports 41(2).
- Hao, Y.; Chung, C.K.; Yu, Z.F.; Veld, R.H.I.V. 't; Ossendorp, F.A.; Dijke, P. ten & Cruz, L.J. (2022), Combinatorial therapeutic approaches with nanomaterial-based photodynamic cancer therapy, Pharmaceutics 14(1).
- Hao, Y.; Chung, C.K.; Gu, Z.L.; Schomann, T.; Dong, X.X.; Veld, R.V.H. in 't; Camps, M.G.M.; Dijke, P. ten; Ossendorp, F.A. & Cruz, L.J. (2022), Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment, Molecular Biomedicine 3.
- Ende T.C. van den, Heuts J.M.M., Gential G.P.P., Visser M., Graaff M.J. van de, Ho N.I., Jiskoot W., Valentijn A.R.P.M., Meeuwenoord N.J., Overkleeft H.S., Codée J.D.C., Burg S.H. van der, Verdegaal E.M.E., Marel G.A. van der, Ossendorp F. & Filippov D.V. (2021), Simplified monopalmitoyl toll-like receptor 2 ligand mini-UPam for self-adjuvanting neoantigen-based synthetic cancer vaccines, ChemBioChem 22(7): 1215-1222.
- Heuts J.M.M., Jiskoot W., Ossendorp F.A. & Maaden K. van der (2021), Cationic nanoparticle-based cancer vaccines, Pharmaceutics 13(5): 596.
- Speetjens F.M., Welters M.J.P., Slingerland M., Steenwijk P.D. van, Roozen I.C.F.M., Boekestijn S., Loof N., Zom G.G., Valentijn R., Krebber W.J., Melief C.J.M., Filippov D.V., Gelderblom H., Burg S.H. van & Ossendorp F.A. (2021), Phase I trial to determine safety and immunogenicity of amplivant, a synthetic toll-like receptor 2 ligand, conjugated to two HPV16 E6 synthetic long peptides, Journal of Clinical Oncology 39(15): 2614-2614.
- Veld, R.V.H.I. 't; Silva, C.G. da; Jager, M.J.; Cruz, L.J. & Ossendorp, F. (2021), Combining photodynamic therapy with immunostimulatory nanoparticles elicits effective anti-tumor immune responses in preclinical murine models, Pharmaceutics 13(9).
- Ho, N.I.; Camps, M.G.M.; Verdoes, M.; Munz, C. & Ossendorp, F. (2021), Autophagy regulates long-term cross-presentation by murine dendritic cells, European Journal of Immunology 51(4): 835-847.
- Leeuwen, T. van; Araman, C.; Pournara, L.P.; Kampstra, A.S.B.; Bakkum, T.; Marqvorsen, M.H.S.; Nascimento, C.R.; Groenewold, G.J.M.; Wulp, W. van der; Camps, M.G.M.; Janssen, G.M.C.; Veelen, P.A. van; Westen, G.J.P. van; Janssen, A.P.A.; Florea, B.I.; Overkleeft, H.S.; Ossendorp, F.A.; Toes, R.E.M. & Kasteren, S.I. van (2021), Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens, RSC Chemical Biology 2(3): 855-862.
- Heuts, J.; Jiskoot, W.; Ossendorp, F. & Maaden, K. van der (2021), Cationic nanoparticle-based cancer vaccines, Pharmaceutics 13(5).
- Ho, N.I.; Camps, M.G.; Garcia-Vallejo, J.J.; Bos, E.; Koster, A.J.; Verdoes, M.; Kooyk, Y. van & Ossendorp, F. (2021), Distinct antigen uptake receptors route to the same storage compartments for cross-presentation in dendritic cells, Immunology 164(3).
- Borst, J.; Busselaar, J.; Bosma, D.M.T. & Ossendorp, F. (2021), Mechanism of action of PD-1 receptor/ligand targeted cancer immunotherapy, European Journal of Immunology 51(8).
- Lara, P.; Veld, R.V.H.I. 't; Jorquera-Cordero, C.; Chan, A.B.; Ossendorp, F. & Cruz, L.J. (2021), Zinc-phthalocyanine-loaded extracellular vesicles increase efficacy and selectivity of photodynamic therapy in co-culture and preclinical models of colon cancer, Pharmaceutics 13(10).
- Fransen, M.F.; Hall, T. van & Ossendorp, F. (2021), Immune checkpoint therapy: tumor draining lymph nodes in the spotlights, International Journal of Molecular Sciences 22(17).
- Reintjens N.R.M., Tondini E., Vis C., McGlinn T., Meeuwenoord N.J., Hogervorst T.P., Overkleeft H.S., Filippov D.V., Marel G.A. van der, Ossendorp F.A. & Codée J.D.C. (2020), Multivalent, stabilized mannose-6-phosphates for the targeted delivery of toll-like receptor ligands and peptide antigens, ChemBioChem 22(2): 434-440.
- Reintjens N.R.M., Tondini E., Jong A.R. de, Meeuwenoord N.J., Chiodo F., Peterse E., Overkleeft H.S., Filippov D.V., Marel G.A. van der, Ossendorp F.A. & Codée J.D.C. (2020), Self-adjuvanting cancer vaccines from conjugation-ready lipid A analogues and synthetic long peptides, Journal of Medicinal Chemistry 63(20): 11691-11706.
- Sow, H.S.; Benonisson, H.; Brouwers, C.; Linssen, M.M.; Camps, M.; Breukel, C.; Claassens, J.; Hall, T. van; Ossendorp, F.; Fransen, M.F. & Verbeek, J.S. (2020), Immunogenicity of rat-neu(+) mouse mammary tumours determines the T cell-dependent therapeutic efficacy of anti-neu monoclonal antibody treatment, Scientific Reports 10(1).
- Gu, Z.L.; Silva, C.G. da; Maaden, K. van der; Ossendorp, F. & Cruz, L.J. (2020), Liposome-based drug delivery systems in cancer immunotherapy, Pharmaceutics 12(11).
- Chung, C.K.; Fransen, M.F.; Maaden, K. van der; Campos, Y.; Garcia-Couce, J.; Kralisch, D.; Chan, A.; Ossendorp, F. & Cruz, L.J. (2020), Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies, Journal of Controlled Release 323: 1-11.
- Ende, T.C. van den; Heuts, J.M.M.; Gential, G.P.P.; Visser, M.; Graaff, M.J. van de; Ho, N.I.; Jiskoot, W.; Valentijn, A.R.P.M.; Meeuwenoord, N.J.; Overkleeft, H.S.; Codee, J.D.C.; Burg, S.H. van der; Verdegaal, E.M.E.; Marel, G.A. van der; Ossendorp, F. & Filippov, D.V. (2020), Simplified monopalmitoyl toll-like receptor 2 ligand mini-U pam for self-adjuvanting neoantigen-based synthetic cancer vaccines, ChemBioChem 22(7).
- Reintjens, N.R.M.; Tondini, E.; Jong, A.R. de; Meeuwenoord, N.J.; Chiodo, F.; Peterse, E.; Overkleeft, H.S.; Filippov, D.V.; Marel, G.A. van der; Ossendorp, F. & Codee, J.D.C. (2020), Self-adjuvanting cancer vaccines from conjugation-ready lipid A analogues and synthetic long peptides, Journal of Medicinal Chemistry 63(20): 11691-11706.
- in't Veld, R.V.H.; Ritsma, L.; Kleinovink, J.W.; Que, I.; Ossendorp, F. & Cruz, L.J. (2020), Photodynamic cancer therapy enhances accumulation of nanoparticles in tumor-associated myeloid cells, Journal of Controlled Release 320: 19-31.
- Reintjens, N.R.M.; Tondini, E.; Vis, C.; McGlinn, T.; Meeuwenoord, N.J.; Hogervorst, T.P.; Overkleeft, H.S.; Filippov, D.V.; Marel, G.A. van der; Ossendorp, F. & Codee, J.D.C. (2020), Multivalent, stabilized mannose-6-phosphates for the targeted delivery of toll-like receptor ligands and peptide antigens, ChemBioChem 22(2).
- Chung, C.K.; Garcia-Couce, J.; Campos, Y.; Kralisch, D.; Bierau, K.; Chan, A.; Ossendorp, F. & Cruz, L.J. (2020), Doxorubicin loaded poloxamer thermosensitive hydrogels, Molecules 25(9).
- Mayoux, M.; Roller, A.; Pulko, V.; Sammicheli, S.; Chen, S.; Sum, E.; Jost, C.; Fransen, M.F.; Buser, R.B.; Kowanetz, M.; Rommel, K.; Matos, I.; Colombetti, S.; Belousov, A.; Karanikas, V.; Ossendorp, F.; Hegde, P.S.; Chen, D.S.; Umana, P.; Perro, M.; Klein, C. & Xu, W. (2020), Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy, Science Translational Medicine 12(534).
- Hernandez, I.B.; Yu, Y.X.; Ossendorp, F.; Korbelik, M. & Oliveira, S. (2020), Preclinical and clinical evidence of immune responses triggered in oncologic photodynamic therapy: clinical recommendations, Journal of Clinical Medicine 9(2).
- Hos, B.J.; Camps, M.G.M.; Bulk, J. van den; Tondini, E.; Ende, T.C. van den; Ruano, D.; Franken, K.; Janssen, G.M.C.; Ru, A.; Filippov, D.V.; Arens, R.; Veelen, P.A. van; Miranda, N. & Ossendorp, F. (2020), Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer, OncoImmunology 9(1).
- Zom G.G., Willems M.M.J.H.P., Meeuwenoord N., Reintjens N.R.M., Tondini E., Khan S., Overkleeft H.S., Marel G.A. van der, Codée J.D.C., Ossendorp F. & Filippov D.V. (2019), Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells, Bioconjugate Chemistry 30(4): 1150-1161.
- Gential G.P.P., Hogervorst T.P., Tondini E., Graaff M.J. van de, Overkleeft H.S., Codée J.D.C., Marel G.A. van der, Ossendorp F. & Filippov D.V. (2019), Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7, Bioorganic and Medicinal Chemistry Letters 29(11): 1340-1344.
- Gential, G.P.P.; Hogervorst, T.P.; Tondini, E.; Graaff, M.J. van de; Overkleeft, H.S.; Codee, J.D.; Marel, G.A. van der; Ossendorp, F. & Filippov, D.V. (2019), Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7, Bioorganic and Medicinal Chemistry Letters 29(11): 1340-1344.
- Beyrend, G.; Gracht, E. van der; Yilmaz, A.; Duikeren, S. van; Camps, M.; Hollt, T.; Vilanova, A.; Unen, V. van; Koning, F.; Miranda, N.F.C.C. de; Arens, R. & Ossendorp, F. (2019), PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors, Journal for ImmunoTherapy of Cancer 7(1).
- Verbeek J. S., Sow H. S., Benonisson H., Breukel C., Visser R., Verhagen O., Bentlage A., Brouwers C., Claassens J., Linssen M., Camps M., van Hall T., Ossendorp F., Herbert-Fransen M. & Vidarsson G. (2019), In anti-PD-L1 immunotherapy Fc gamma R interaction can add additional benefit depending on the tumor model, European Journal of Immunology 49: 1733-1734.
- Silva, C.G. da; Camps, M.G.M.; Li, T.M.W.Y.; Zerrillo, L.; Lowik, C.W.; Ossendorp, F. & Cruz, L.J. (2019), Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles, Theranostics 9(22): 6485-6500.
- Sow, H.S.; Benonisson, H.; Breukel, C.; Visser, R.; Verhagen, O.J.H.M.; Bentlage, A.E.H.; Brouwers, C.; Claassens, J.W.C.; Linssen, M.M.; Camps, M.; Hall, T. van; Ossendorp, F.; Fransen, M.F.; Vidarsson, G. & Verbeek, J.S. (2019), Fc gamma R interaction is not required for effective anti-PD-L1 immunotherapy but can add additional benefit depending on the tumor model, International Journal of Cancer 144(2): 345-354.
- Sow, H.S.; Benonisson, H.; Breukel, C.; Visser, R.; Verhagen, O.J.H.M.; Bentlage, A.E.H.; Brouwers, C.; Claassens, J.W.C.; Linssen, M.M.; Camps, M.; Hall, T. van; Ossendorp, F.; Fransen, M.F.; Vidarsson, G. & Verbeek, J.S. (2019), Fc gamma R interaction is not required for effective anti-PD-L1 immunotherapy but can add additional benefit depending on the tumor model, International Journal of Cancer 144(2): 345-354.
- Beyrend, G.; Stam, K.; Ossendorp, F. & Arens, R. (2019), Visualization and Quantification of High-Dimensional Cytometry Data using Cytofast and the Upstream Clustering Methods FlowSOM and Cytosplore, Journal of Visualized Experiments.
- Zom, G.G.; Willems, M.M.J.H.P.; Meeuwenoord, N.J.; Reintjens, N.R.M.; Tondini, E.; Khan, S.; Overkleeft, H.S.; Marel, G.A. van der; Codee, J.D.C.; Ossendorp, F. & Filippov, D.V. (2019), Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells, Bioconjugate Chemistry 30(4): 1150-1161.
- Sow, H.S.; Ren, J.; Camps, M.; Ossendorp, F. & Dijke, P. ten (2019), Combined Inhibition of TGF- Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models.
- Beyrend, G.; Gracht, E. van der; Yilmaz, A.; Duikeren, S. van; Camps, M.; Hollt, T.; Vilanova, A.; Unen, V. van; Koning, F.; Miranda, N.F.C.C. de; Arens, R. & Ossendorp, F. (2019), PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors, Journal for ImmunoTherapy of Cancer 7(1).
- Kleinovink, J.W.; Mezzanotte, L.; Zambito, G.; Fransen, M.F.; Cruz, L.J.; Verbeek, J.S.; Chan, A.; Ossendorp, F. & Lowik, C. (2019), A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function, Frontiers in Immunology 9.
- Silva, C.G. da; Camps, M.G.M.; Li, T.M.W.Y.; Chan, A.B.; Ossendorp, F. & Cruz, L.J. (2019), Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines, Biomaterials 220.
- Kordalivand, N.; Tondini, E.; Lau, C.Y.J.; Vermonden, T.; Mastrobattista, E.; Hennink, W.E.; Ossendorp, F. & Nostrum, C.F. van (2019), Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses, Journal of Controlled Release 315: 114-125.
- Tondini, E.; Arakelian, T.; Oosterhuis, K.; Camps, M.; Duikeren, S. van; Han, W.D.; Arens, R.; Zondag, G.; Bergen, J. van & Ossendorp, F. (2019), A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control, OncoImmunology 8(11).
- Mangsbo S.M., Fletcher E.A.K., Maren W.W.C. van, Redeker A., Cordfunke R.A., Dillmann I., Dinkelaar J., Ouchaou K., Codee J.D.C., Marel G.A. van der, Hoogerhout P., Melief C.J.M., Ossendorp F. & Drijfhout J.W. (2018), Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses, Molecular Immunology 93: 115-124.
- Maaden K. van der, Heuts J.M.M., Camps M.G.M., Pontier M.J., Terwisscha van Scheltinga A., Jiskoot W., Ossendorp F.A. & Bouwstra J.A. (2018), Hollow microneedle-mediated micro-injections of a liposomal HPV E7(43-63) synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses, Journal of Controlled Release 269: 347-354.
- Hos B.J., Tondini E., Kasteren S.I. van & Ossendorp F.A. (2018), Approaches to Improve Chemically Defined Synthetic Peptide Vaccines, Frontiers in Immunology 9: 884.
- Fletcher E.A.K., Maren W. van, Cordfunke R., Dinkelaar J., Codee J.D.C., Marel G.A. van der, Melief C.J.M., Ossendorp F., Drijfhout J.W. & Mangsbo S.M. (2018), Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System, Journal of Immunology 201(1): 87-97.
- Zom G.G., Willems M.M.J.H.P., Khan S., Sluis T.C. van der, Kleinovink J.W., Camps M.G.M., Marel G.A. van der, Filippov D.V., Melief C.J.M. & Ossendorp F.A. (2018), Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication, Journal for ImmunoTherapy of Cancer 6(1): 146.
- Zom, G.G.; Willems, M.M.J.H.P.; Khan, S.; Sluis, T.C. van der; Kleinovink, J.W.; Camps, M.G.M.; Marel, G.A. van der; Filippov, D.V.; Melief, C.J.M. & Ossendorp, F. (2018), Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication, Journal for ImmunoTherapy of Cancer 6.
- Fransen, M.F.; Schoonderwoerd, M.; Knopf, P.; Camps, M.G.M.; Hawinkels, L.J.A.C.; Kneilling, M.; Hall, T. van & Ossendorp, F. (2018), Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy, JCI insight 3(23).
- Fletcher, E.A.K.; Maren, W. van; Cordfunke, R.; Dinkelaar, J.; Codee, J.D.C.; Marel, G. van der; Melief, C.J.M.; Ossendorp, F.; Drijfhout, J.W. & Mangsbo, S.M. (2018), Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System, Journal of Immunology 201(1): 87-97.
- Benonisson, H.; Sow, H.S.; Breukel, C.; Claassens, J.; Brouwers, C.; Linssen, M.M.; Fransen, M.F.; Sluijter, M.; Ossendorp, F.; Hall, T. van & Verbeek, J.S. (2018), High Fc gamma R Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy, Journal of Immunology 201(12): 3741-3749.
- Ho, N.I.; Camps, M.G.M.; Haas, E.F.E. de & Ossendorp, F. (2018), Sustained cross-presentation capacity of murine splenic dendritic cell subsets in vivo, European Journal of Immunology 48(7): 1164-1173.
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- Heukamp LC, van Hall T, Ossendorp F, Burchell JM, Melief CJM, Taylor-Papadimitriou J & Offringa R (2002), Effective immunotherapy of cancer in MUC1-transgenic mice using clonal cytotoxic T lymphocytes directed against an immunodominant MUC1 epitope, Journal of Immunotherapy 25(1).
- Schuurhuis DH, Ioan-Facsinay A, Nagelkerken B, van Schip JJ, Sedlik C, Melief CJM, Verbeek JS & Ossendorp F (2002), Antigen-antibody immune complexes empower dendritic cells to efficiently prime specific CD8(+) CTL responses in vivo, Journal of Immunology 168(5).
- Kessler JH, Beekman NJ, Bres-Vloemans SA, Verdijk P, van Veelen PA, Kloosterman-Joosten AM, Vissers DCJ, ten Bosch GJA, Kester MGD, Sijts A, Drijfhout JW, Ossendorp F, Offringa R & Melief CJM (2001), Efficient identification of novel HLA-A*0201-presented cytotoxic T lymphocyte epitopes in the widely expressed tumor antigen PRAME by proteasome-mediated digestion analysis, Journal of Experimental Medicine 193(1).
- Medema JP, Schuurhuis DH, Rea D, van Tongeren J, de Jong J, Bres SA, Laban S, Toes REM, Toebes M, Schumacher TNM, Bladergroen BA, Ossendorp F, Kummer JA, Melief CJM & Offringa R (2001), Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: Differential modulation by T helper type 1 and type 2 cells, Journal of Experimental Medicine 194(5).
- Kleijmeer M, Ramm G, Schuurhuis D, Griffith J, Rescigno M, Ricciardi-Castagnoli P, Rudensky AY, Ossendorp F, Melief CJM, Stoorvogel W & Geuze HJ (2001), Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells, Journal of Cell Biology 155(1).
- Charo J, Geluk A, Sundback M, Mirzai B, Diehl AD, Malmberg KJ, Achour A, Huriguchi S, van Meijgaarden KE, Drijfhout JW, Beekman N, van Veelen P, Ossendorp F, Ottenhoff THM & Kiessling R (2001), The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65, European Journal of Immunology 31(12).
- Beekman NJ, van Veelen PA, van Hall T, Neisig A, Sijts A, Camps M, Kloetzel PM, Neefjes JJ, Melief CJ & Ossendorp F (2000), Abrogation of CTL epitope processing by single amino acid substitution flanking the C-terminal proteasome cleavage site.
- van Hall T, van Bergen J, van Veelen PA, Kraakman M, Henkamp LC, Koning F, Melief CJM, Ossendorp F & Offringa R (2000), Identification of a novel tumor-specific CTL epitope presented by RMA, EL-4, and MBL-2 lymphomas reveals their common origin.
- Schuurhuis DH, Laban S, Toes REM, Ricciardi-Castagnoli P, Kleijmeer MJ, van der Voort EIH, Rea D, Offringa R, Geuze HJ, Melief CJM & Ossendorp F (2000), Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli.
- van Hall T, Sijts A, Camps M, Offringa R, Melief C, Kloetzel PM & Ossendorp F (2000), Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28.
- Offringa R, van der Burg SH, Ossendorp F, Toes REM & Melief CJM (2000), Design and evaluation of antigen-specific vaccination strategies against cancer, Current Opinion in Immunology 12(5).
- Melief CJM, Toes REM, Medema JP, Van der Burg SH, Ossendorp F & Offringa R (2000), Strategies for immunotherapy of cancer, Advances in Immunology 75.
- Ossendorp F, Toes REM, Offringa R, van der Burg SH & Melief CJM (2000), Importance of CD4(+) T helper cell responses in tumor immunity, Immunology Letters 74(1).
- van Bergen J, Camps M, Offringa R, Melief CJM, Ossendorp F & Koning F (2000), Superior tumor protection induced by a cellular vaccine carrying a tumor-specific T helper epitope by genetic exchange of the class II-associated invariant chain peptide, Cancer Research 60(22).
- Sijts AJAM, Standera S, Toes REM, Ruppert T, Beekman NJCM, van Veelen PA, Ossendorp FA, Melief CJM & Kloetzel PM (2000), MHC class I antigen processing of an Adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells.
- van Bergen J, Ossendorp F, Jordens R, Mommaas AM, Drijfhout JW & Koning F (1999), Get into the groove! Targeting antigens to MHC class II.
- Adviseur
- Lid wetenschappelijke raad van KWF