Bas Heijmans
Hoogleraar Biomedische Datawetenschappen, in het bijzonder Populatie Epigenomica
- Naam
- Prof.dr. B.T. Heijmans
- Telefoon
- +31 71 526 9785
- b.t.heijmans@lumc.nl
- ORCID iD
- 0000-0001-5918-0534
Bas Heijmans is hoogleraar Biomedische Datawetenschappen en richt zich specifiek op Populatie Epigenomica. Hij is gegrepen door de vraag hoe de regulatie van ons DNA kan veranderen door de omgeving en genetische aanleg, en hoe dit proces onze gezondheid blijvend kan beïnvloeden. Als wetenschappelijk coördinator van het LUMC-brede onderzoeksthema Medical Genomics is hij lid van de Research Council. Ook is Heijmans door de Nederlandse Hartstichting benoemd tot Established Investigator.
Meer informatie over Bas Heijmans
Zie ook:
Epigenetica
Epigenetica brengt het DNA tot leven. Elke cel van het lichaam bevat hetzelfde DNA met de code voor dezelfde ruim 20 duizend genen, terwijl in ieder type cel, van hartcel tot hersencel, een heel ander deel van die genen ‘aan’ of ‘uit’ moet staan om goed te kunnen werken. Welke dat zijn bepaalt epigenetica door middel van moleculaire dimmers op het DNA. Maar: de precieze afstelling van de dimmers blijkt niet definitief en kan veranderen door de omgeving. Wereldwijd bekend onderzoek van Heijmans bij Hongerwinterkinderen heeft laten zien dat ondervoeding tijdens de zwangerschap gepaard gaat met epigenetische veranderingen die decennia later nog altijd zichtbaar zijn en de gezondheidsproblemen bij deze groep mensen kunnen verklaren. Nu leidt Heijmans een onderzoek bij bijzondere eeneiige tweelingen die samen één placenta delen. Dit is een patiëntengroep die vanuit het hele land naar het LUMC komt voor topreferente zorg. Eén van de tweelingen krijgt vaak te maken met een tekort aan voedingsstoffen doordat de placenta ongelijk verdeeld is. Samen met een multidisciplinair onderzoeksteam brengt hij in kaart wat de gevolgen zijn voor hart- en bloedvaten, de groei en de neurologische ontwikkeling, en bestudeert hij speciale stamcel-achtige cellen uit de navelstreng om te achterhalen welke epigenetische veranderingen hiervoor verantwoordelijk zijn. Dit moet op termijn niet alleen de zorg voor deze kwetsbare tweelingen verbeteren, maar ook voor alle andere kinderen die geboren worden uit een gecompliceerde zwangerschap. Want: de tweelingen zijn genetisch identiek, en daarom is het juist bij hen mogelijk om heel precies te achterhalen hoe gezondheidsproblemen ontstaan.
Datawetenschappen
Het bredere doel van Heijmans is om te ontrafelen hoe een verstoorde regulatie van het genoom bijdraagt aan het ontstaan van hart- en vaatziekten en de snelheid van het verouderingsproces in de algemene bevolking. Daartoe maakt zijn onderzoeksgroep gebruik van omvangrijke databestanden met gegevens van grote groepen mensen. De gegevens betreffen naast de DNA-code (het genoom), zo volledig mogelijke informatie over de epigenetische afstelling (het epigenoom) en de activiteit van alle genen (het transcriptoom). De kunst is om de enorme hoeveelheid data te ondervragen met slimme, gerichte analysetechnieken om exact te ontrafelen wat er mis gaat als iemand ziek wordt. Als zo een patroon van relevante genen gevonden is, dan verplaatst het onderzoek zich naar het laboratorium om met cellen van patiënten een ziekteproces in meer detail op te helderen. Het ultieme doel van het onderzoek is om preventie en behandeling op maat van verouderings-gerelateerde ziekten mogelijk te maken.
Wetenschappelijke carrière
Bas Heijmans studeerde Biologie aan de Universiteit Leiden (cum laude) en promoveerde aan dezelfde universiteit op onderzoek dat hij verrichte bij TNO. De titel van zijn proefschrift (2000) luidt ‘Common Gene variants and mortality in the population at large’. Sindsdien is hij werkzaam bij het Leids Universitair Medisch Centrum, de eerste jaren op het gebied van genetische epidemiologie en sinds 2006 als groepsleider met een focus op epigenetica. Hij initieerde in 2011 het BIOS Consortium waarin Nederlandse biobanken multi-omics data delen met als resultaat tot nu toe meer dan 50 publicaties in gerenommeerde tijdschriften. Ook leidt hij de Twinlife studie, een samenwerking met het LUMC Willem-Alexander Kinderziekenhuis. In mei 2020 werd hij benoemd tot Hoogleraar Populatie Epigenomica en op 22 april 2022 sprak hij zijn oratie uit getiteld Zoeken op het snijvlak. Hij is wetenschappelijk coördinator van het LUMC-brede onderzoeksthema Medical Genomics. Daarnaast is hij lid van de Dekkerbeurzencommissie van de Hartstichting en organisatiecomités van de Wellcome Trust conferentie Epigenomics of Common Diseases en het congres NWO Life. Tot slot is hij als redacteur verbonden aan het wetenschappelijke tijdschrift Aging Cell met als focus epigenetica.
Prijzen en eervolle benoemingen
Bas Heijmans is door de Hartstichting benoemd tot Established Investigator (2017). In 2018 ontving hij de Nederlandse Data Prijs namens samenwerkende biobanken die hun omics data delen via het BIOS Consortium en het BBMRI-omics data platform. In 2019 won hij de Grant for Growth Innovation.
Hoogleraar Biomedische Datawetenschappen, in het bijzonder Populatie Epigenomica
- Faculteit Geneeskunde
- Divisie 4
- Biomedical Data Sciences
- Luna, J.L. de; Nounu, A.; Neumeyer, S.; Sinke, L.; Wilson, R.; Hellbach, F.; Matías-García, P.R.; Delerue, T.; Winkelmann, J.; Peters, A.; Thorand, B.; Beekman, M.; Heijmans, B.T.; Slagboom, E.; Gieger, C.; Linseisen, J. & Waldenberger, M. (2024), Epigenome-wide association study of dietary fatty acid intake, Clinical Epigenetics 16(1).
- Cheng, M.L.; Conley, D.; Kuipers, T.; Li, C.H.; Ryan, C.P.; Wang, S.; Wang, T.; Zhou, J.Y.; Schmitz, L.L.; Tobi, E.W.; Heijmans, B.; Lumey, L.H.; Belsky, D.W. & Taeubert, M.J. (2024), Accelerated biological aging six decades after prenatal famine exposure, Proceedings of the National Academy of Sciences 121(24).
- Reilly, N.A.; Sonnet, F.; Dekkers, K.F.; Kwekkeboom, J.C.; Sinke, L.; Hilt, S.; Suleiman, H.M.; Hoeksema, M.A.; Mei, H.L.; Zwet, E.W. van; Everts, B.; Ioan-Facsinay, A.; Jukema, J.W. & Heijmans, B.T. (2024), Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation, iScience 27(4).
- Todtenhaupt, P.; Kuipers, T.B.; Dijkstra, K.L.; Voortman, L.M.; Franken, L.A.; Spekman, J.A.; Jonkman, T.H.; Groene, S.G.; Roest, A.A.; Haak, M.C.; Verweij, E.; Pel, M. van; Lopriore, E.; Heijmans, B. & Meeren, L.E. van der (2024), Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twins, Life Science Alliance 7(8).
- Dekkers, K.F.; Slieker, R.C.; Ioan-Facsinay, A.; Iterson, M. van; Ikram, M.A.; Greevenbroek, M.M.J. van; Veldink, J.H.; Franke, L.; Boomsma, D.I.; Slagboom, P.E.; Jukema, J.W.; Heijmans, B.T. & BIOS consortium (2023), Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response, Nature Communications 14(1).
- Todtenhaupt, P.; Franken, L.A.; Groene, S.G.; Hoolwerff, M. van; Meeren, L.E. van der; Klink, J.M.M. van; Roest, A.A.W.; Bruin, C. de; Ramos, Y.F.M.; Haak, M.C.; Lopriore, E.; Heijmans, B.T. & Pel, M. van (2023), A robust and standardized method to isolate and expand mesenchymal stromal cells from human umbilical cord, Cytotherapy 25(10): 1057-1068.
- Groene, S.G.; Gremmen, I.J.; Zwet, E.W. van; Roest, A.A.W.; Haak, M.C.; Klink, J.M.M. van; Lopriore, E.; Heijmans, B.T. & Bruin, C. de (2023), Fetal growth restriction inhibits childhood growth despite catch-up in discordant identical twins, European journal of endocrinology 189(2): 183-189.
- Costeira, R.; Evangelista, L.; Wilson, R.; Yan, X.Y.; Hellbach, F.; Sinke, L.; Christiansen, C.; Villicana, S.; Masachs, O.M.; Tsai, P.C.; Mangino, M.; Menni, C.; Berry, S.E.; Beekman, M.; Heemst, D. van; Slagboom, P.E.; Heijmans, B.T.; Suhre, K.; Kastenmueller, G.; Gieger, C.; Peters, A.; Small, K.S.; Linseisen, J.; Waldenberger, M. & Bell, J.T. (2023), Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome, Clinical Epigenetics 15(1).
- Walton, E.; Baltramonaityte, V.; Calhoun, V.; Heijmans, B.T.; Thompson, P.M. & Cecil, C.A.M. (2023), A systematic review of neuroimaging epigenetic research: calling for an increased focus on development, Molecular Psychiatry 28(7): 2839-2847.
- Costeira, R.; Ruiz, L.D.; Sinke, L.; Christiansen, C.; Heijmans, B.; Slagboom, E.; Waldenberger, M.; Berry, S.; Ordovás, J.M. & Bell, J.T. (2023), Human DNA methylation trajectories of the postprandial metabolic response to food, Annals of Nutrition and Metabolism 79: 353-353.
- Liu, Y.F.; Sinke, L.; Jonkman, T.H.; Slieker, R.C.; Zwet, E.W. van; Daxinger, L.; Heijmans, B.T. & BIOS Consortium (2023), The inactive X chromosome accumulates widespread epigenetic variability with age, Clinical Epigenetics 15(1).
- Kreitmaier, P.; Suderman, M.; Southam, L.; Almeida, R.C. de; Hatzikotoulas, K.; Meulenbelt, I.; Steinberg, J.; Relton, C.; Wilkinson, J.M. & Zeggini, E. (2022), AN EPIGENOME-WIDE VIEW OF OSTEOARTHRITIS IN PRIMARY TISSUES, Osteoarthritis and Cartilage 30: S48-S48.
- Tuerlings, M.; Janssen, G.; Boone, I.; Hoolwerff, M. van; Ruiz, A.R.; Houtman, E.; Suchiman, E.; Wal, R. van der; Nelissen, R.; Almeida, R.C. de; Veelen, P. van; Ramos, Y. & Meulenbelt, I. (2022), FUNCTIONAL GENOMICS HIGHLIGHTS ROLE FOR OSTEOARTHRITIS SUSCEPTIBILITY GENE WWP2 IN CARTILAGE MATRIX DEPOSITION, Osteoarthritis and Cartilage 30: S180-S180.
- Hoolwerff, M. van; Tuerlings, M.; Wijnen, I.J.; Suchiman, E.H.; Cats, D.; Nelissen, R.G.; Linden, E.M. van der; Mei, H.; Ramos, Y.F.; Almeida, R.C. de & Meulenbelt, I. (2022), IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION IMBALANCED OSTEOARTHRITIS ASSOCIATED FIBRONECTIN SPLICE VARIANTS, Osteoarthritis and Cartilage 30: S17-S18.
- Hoolwerff, M. van; Tuerlings, M.; Wijnen, I.J.L.; Suchiman, H.E.D.; Cats, D.; Mei, H.L.; Nelissen, R.G.H.H.; Linden-van der Zwaag, H.M.J. van der; Ramos, Y.F.M.; Almeida, R.C. de & Meulenbelt, I. (2022), Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants, Rheumatology 62(2).
- Houtman, E.; Tuerlings, M.; Suchiman, H.E.D.; Lakenberg, N.; Cornelis, F.M.F.; Mei, H.L.; Broekhuis, D.; Nelissen, R.G.H.H.; Almeida, R.C. de; Ramos, Y.F.M.; Lories, R.J.; Cruz, L.J. & Meulenbelt, I. (2022), Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes, Rheumatology 62(1).
- Ruiz, A.R.; Hoolwerff, M. van; Sprangers, S.; Suchiman, E.; Schoenmaker, T.; Dibbets-Schneider, P.; Bloem, J.L.; Nelissen, R.G.H.H.; Freund, C.; Mummery, C.; Everts, V.; Vries, T.J. de; Ramos, Y.F.M. & Meulenbelt, I. (2022), Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization, Rheumatology 62(1).
- Timmermans, R.G.; Bloks, N.G.; Lent, P.L. van; Kraan, P.M. van der; Nelissen, R.G.; Blom, A.B.; Meulenbelt, I.; Bosch, M.H. van den & Ramos, Y.F. (2022), OPPOSITE EFFECTS OF HYPER-PHYSIOLOGICAL MECHANICAL STRESS AND INFLAMMATION ON WNT SIGNALING IN HUMAN CHONDROCYTE NEO-CARTILAGE PELLETS, Osteoarthritis and Cartilage 30: S165-S165.
- Bloks, N.G.; Harissa, Z.; Dicks, A.; Almeida, R.C. de; Hajmousa, G.; Adkar, S.S.; Guilak, F.; Ramos, Y.F. & Meulenbelt, I. (2022), OSTEOARTHRITIS-RISK MUTATION IN PERICELLULAR MATRIX COL6A3 FIBRILS ALTERS BIOLOGIC RESPONSE OF CHONDROCYTES TO HYPER-PHYSIOLOGIC MECHANICAL LOADING CONDITIONS, Osteoarthritis and Cartilage 30: S12-S13.
- Korthagen, N.; Houtman, E.; Boone, I.; Almeida, R.C. de; Sivasubramaniyan, K.; Nelissen, R.; Ramos, Y.; Tessari, M. & Meulenbelt, I. (2022), RNA SEQUENCING REVEALS MARKERS AND PATHWAYS OF T3-INDUCED CARTILAGE HYPERTROPHY, Tissue Engineering Part A 28: S601-S601.
- Korthagen, N.M.; Houtman, E.; Boone, I.; Almeida, R.C. de; Sivasubramaniyan, K.; Nelissen, R.G.; Ramos, Y.F.; Tessari, M.A. & Meulenbelt, I. (2022), RNA SEQUENCING REVEALS NOVEL MARKERS AND PATHWAYS OF T3-INDUCED CARTILAGE HYPERTROPHY, Osteoarthritis and Cartilage 30: S345-S346.
- Hellbach, F.; Sinke, L.; Costeira, R.; Baumeister, S.E.; Beekman, M.; Louca, P.; Leeming, E.R.; Mompeo, O.; Berry, S.; Wilson, R.; Wawro, N.; Freuer, D.; Hauner, H.; Peters, A.; Winkelmann, J.; Koenig, W.; Meisinger, C.; Waldenberger, M.; Heijmans, B.T.; Slagboom, P.E.; Bell, J.T. & Linseisen, J. (2022), Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS, European Journal of Nutrition 62.
- Todtenhaupt, P.; Pel, M. van; Roest, A.A.W. & Heijmans, B.T. (2022), Mesenchymal stromal cells as a tool to unravel the developmental origins of disease, Trends in Endocrinology & Metabolism 33(9): 614-627.
- Wielscher, M.; Mandaviya, P.R.; Kuehnel, B.; Joehanes, R.; Mustafa, R.; Robinson, O.; Zhang, Y.; Bodinier, B.; Walton, E.; Mishra, P.P.; Schlosser, P.; Wilson, R.; Tsai, P.C.; Palaniswamy, S.; Marioni, R.E.; Fiorito, G.; Cugliari, G.; Karhunen, V.; Ghanbari, M.; Psaty, B.M.; Loh, M.; Bis, J.C.; Lehne, B.; Sotoodehnia, N.; Deary, I.J.; Chadeau-Hyam, M.; Brody, J.A.; Cardona, A.; Selvin, E.; Smith, A.K.; Miller, A.H.; Torres, M.A.; Marouli, E.; Gao, X.; Meurs, J.B.J. van; Graf-Schindler, J.; Rathmann, W.; Koenig, W.; Peters, A.; Weninger, W.; Farlik, M.; Zhang, T.; Chen, W.; Xia, Y.J.; Teumer, A.; Nauck, M.; Grabe, H.J.; Doerr, M.; Lehtimaki, T.; Guan, W.H.; Milani, L.; Tanaka, T.; Fisher, K.; Waite, L.L.; Kasela, S.; Vineis, P.; Verweij, N.; Harst, P. van der; Iacoviello, L.; Sacerdote, C.; Panico, S.; Krogh, V.; Tumino, R.; Tzala, E.; Matullo, G.; Hurme, M.A.; Raitakari, O.T.; Colicino, E.; Baccarelli, A.A.; Kahonen, M.; Herzig, K.H.; Li, S.X.; Conneely, K.N.; Kooner, J.S.; Kottgen, A.; Heijmans, B.T.; Deloukas, P.; Relton, C.; Ong, K.K.; Bell, J.T.; Boerwinkle, E.; Elliott, P.; Brenner, H.; Beekman, M.; Levy, D.; Waldenberger, M.; Chambers, J.C.; Dehghan, A.; Jarvelin, M.R. & BIOS Consortium (2022), DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases, Nature Communications 13(1).
- Feiner, N.; Radersma, R.; Vasquez, L.; Ringner, M.; Nystedt, B.; Raine, A.; Tobi, E.W.; Heijmans, B.T. & Uller, T. (2022), Environmentally induced DNA methylation is inherited across generations in an aquatic keystone species, iScience 25(5).
- Groene, S.G.; Stegmeijer, K.J.J.; Tan, R.N.G.B.; Steggerda, S.J.; Haak, M.C.; Slaghekke, F.; Roest, A.A.W.; Heijmans, B.; Lopriore, E. & Klink, J.M.M. van (2022), Long-term effects of selective fetal growth restriction (LEMON), The Lancet Child & Adolescent Health 6(9): 624-632.
- Groene, S.G.; Vries, L.S. de; Slaghekke, F.; Haak, M.C.; Heijmans, B.T.; Bruin, C. de; Roest, A.A.W.; Lopriore, E.; Klink, J.M.M. van & Steggerda, S.J. (2022), Changes in structural brain development after selective fetal growth restriction in monochorionic twins, Ultrasound in Obstetrics & Gynecology 59(6): 747-755.
- Jonkman, T.H.; Dekkers, K.F.; Slieker, R.C.; Grant, C.D.; Ikram, M.A.; Greevenbroek, M.M.J. van; Franke, L.; Veldink, J.H.; Boomsma, D.I.; Slagboom, P.E.; Consortium, B.I.O.S. & Heijmans, B.T. (2022), Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression, Genome Biology 23(1).
- Groene, S.G.; Openshaw, K.M.; Jansen-Storbacka, L.R.; Slaghekke, F.; Haak, M.C.; Heijmans, B.T.; Klink, J.M.M. van; Roest, A.A.W.; Meeren, L.E. van der & Lopriore, E. (2022), Impact of placental sharing and large bidirectional anastomoses on birthweight discordance in monochorionic twins, American Journal of Obstetrics & Gynecology 227(5).
- Almeida, R.C. de; Tuerlings, M.; Ramos, Y.; Hollander, W. den; Suchiman, E.; Lakenberg, N.; Nelissen, R.G.H.H.; Mei, H.L. & Meulenbelt, I. (2022), Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis, Rheumatology.
- Katsoula, G.; Steinberg, J.; Tuerlings, M.; Almeida, R.C. de; Southam, L.; Swift, D.; Meulenbelt, I.; Wilkinson, J.M. & Zeggini, E. (2022), A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis, Human Molecular Genetics 31(12).
- Katsoula, G.; Steinberg, J.; Tuerlings, M.; Almeida, R.C. de; Southam, L.; Swift, D.; Meulenbelt, I.; Wilkinson, J.M. & Zeggini, E. (2022), A MOLECULAR MAP OF LONG NON-CODING RNA EXPRESSION, ISOFORM SWITCHING AND ALTERNATIVE SPLICING IN OSTEOARTHRITIS, Osteoarthritis and Cartilage 30: S352-S352.
- Kreitmaier, P.; Suderman, M.; Southam, L.; Almeida, R.C. de; Hatzikotoulas, K.; Meulenbelt, I.; Steinberg, J.; Relton, C.; Wilkinson, J.M. & Zeggini, E. (2022), An epigenome-wide view of osteoarthritis in primary tissues, European Journal of Human Genetics 30(SUPPL 1): 66-67.
- Ramos, Y.F.M.; Meulenbelt, I. & Meijer, J.H. (2022), Clock genes for joint health: if we could turn back time, Rheumatology 61(1): 3-5.
- Boone, I.; Tuerlings, M.; Almeida, R.C. de; Lehmann, J.; Nelissen, R.G.; Keizer, P.L. de & Meulenbelt, I. (2022), BLOOD MICRO-RNAS DELINEATING SENESCENCE PHENOTYPES IN OSTEOARTHRITIS, Osteoarthritis and Cartilage 30: S130-S130.
- Tuerlings, M.; Boone, I.; Amirabadi, H.E.; Vis, M.; Suchiman, E.; Linden, E. van der; Hofmann, S.; Nelissen, R.; Toonder, J.; Ramos, Y. & Meulenbelt, I. (2022), Capturing essential physiological aspects of interacting cartilage and bone tissue with osteoarthritis pathophysiology, Advanced Materials Technologies 7(8).
- Timmermans, R.G.M.; Blom, A.B.; Bloks, N.G.C.; Nelissen, R.G.H.H.; Linden, E.H.M.J. van der; Kraan, P.M. van der; Meulenbelt, I.; Ramos, Y.F.M. & Bosch, M.H.J. van den (2022), CCN4/WISP1 promotes migration of human primary osteoarthritic chondrocytes, Cartilage 14(1).
- Ramos, Y.F.M.; Tertel, T.; Shaw, G.; Staubach, S.; Almeida, R.C. de; Suchiman, E.; Kuipers, T.B.; Mei, H.L.; Barry, F.; Murphy, M.; Giebel, B. & Meulenbelt, I. (2022), Characterizing the secretome of licensed hiPSC-derived MSCs, Stem Cell Research and Therapy 13(1).
- Herzog, E.M.; Eggink, A.J.; Willemsen, S.P.; Slieker, R.C.; Felix, J.F.; Stubbs, A.P.; Spek, P.J. van der; Meurs, J.B.J. van; Heijmans, B.T. & Steegers-Theunissen, R.P.M. (2021), The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues, Journal of Developmental Origins of Health and Disease 12(1): 113-123.
- Reilly, N.A.; Lutgens, E.; Kuiper, J.; Heijmans, B.T. & Jukema, J.W. (2021), Effects of fatty acids on T cell function, Nature Reviews Cardiology 18.
- Sinke, L.; Cats, D. & Heijmans, B.T. (2021), Omixer: multivariate and reproducible sample randomization to proactively counter batch effects in omics studies, Bioinformatics 37(18): 3051-3052.
- Bos, M.M.; Goulding, N.J.; Lee, M.; Hofman, A.; Bot, M.; Pool, R.; Vijfhuizen, L.; Zhang, X.; Li, C.; Mustafa, R.; Neville, M.J.; Li-Gao, R.; Trompet, S.; Beekman, M.; Biermasz, N.R.; Boomsma, D.I.; Boer, I. de; Christodoulides, C.; Dehghan, A.; Dijk, K.W. van; Ford, I.; Ghanbari, M.; Heijmans, B.T.; Ikram, M.A.; Jukema, J.W.; Mook-Kanamori, D.O.; Karpe, F.; Luik, A.I.; Lumey, L.; Maagdenberg, A.M. van den; Mooijaart, S.P.; Mutsert, R. de; Penninx, B.W.J.H.; Rensen, P.C.N.; Richmond, R.C.; Rosendaal, F.R.; Sattar, N.; Schoevers, R.; Slagboom, P.E.; Terwindt, G.M.; Thesing, C.S.; Wade, K.; Wijsman, C.A.; Willemsen, G.; Zinderman, A.; Verwoert, G.C.; Noordam, R. & Lawlor, D.A. (2021), INVESTIGATING THE RELATIONSHIPS BETWEEN UNFAVORABLE SLEEP AND METABOLOMIC TRAITS: EVIDENCE FROM MULTI-COHORT MULTIVARIABLE REGRESSION AND MENDELIAN RANDOMIZATION ANALYSES, Atherosclerosis 331: E42-E42.
- Dongen, J. van; Gordon, S.D.; McRae, A.F.; Odintsova, V.V.; Mbarek, H.; Breeze, C.E.; Sugden, K.; Lundgren, S.; Castillo-Fernandez, J.E.; Hannon, E.; Moffitt, T.E.; Hagenbeek, F.A.; Beijsterveldt, C.E.M. van; Hottenga, J.J.; Tsai, P.C.; Min, J.L.; Hemani, G.; Ehli, E.A.; Paul, F.; Stern, C.D.; Heijmans, B.T.; Slagboom, P.E.; Daxinger, L.; Maarel, S.M. van der; Geus, E.J.C. de; Willemsen, G.; Montgomery, G.W.; Reversade, B.; Ollikainen, M.; Kaprio, J.; Spector, T.D.; Bell, J.T.; Mill, J.; Caspi, A.; Martin, N.G.; Boomsma, D.I.; Bios Consortium & Genetics DNA Methylation Consortiu (2021), Identical twins carry a persistent epigenetic signature of early genome programming, Nature Communications 12(1).
- Hartman, R.; Siemelink, M.; Haitjema, S.; Dekkers, K.F.; Slenders, L.; Boltjes, A.; Mokry, M.; Timmerman, N.; Borst, G.J. de; Heijmans, B.T.; Asselbergs, F.W.; Pasterkamp, G.; Laan, S.W. van der & Ruijter, H.M. den (2021), SEX-DEPENDENT GENE REGULATION OF HUMAN ATHEROSCLEROTIC PLAQUES BY DNA METHYLATION AND TRANSCRIPTOME INTEGRATION POINTS TO SMOOTH MUSCLE CELL INVOLVEMENT IN WOMEN., Atherosclerosis 331: E217-E217.
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- Tobi, E.W.; Almqvist, C.; Hedman, A.; Andolf, E.; Holte, J.; Olofsson, J.I.; Wramsby, H.; Wramsby, M.; Pershagen, G.; Heijmans, B.T. & Iliadou, A.N. (2021), DNA methylation differences at birth after conception through ART, Human Reproduction 36(1): 248-259.
- Reilly, N.A.; Dekkers, K.F.; Sinke, L.; Hilt, S.T.; Ioan-Facsinay, A.; Jukema, J.W. & Heijmans, B.T. (2021), FATTY ACID-INDUCED TRANSCRIPTOMIC AND METHYLOMIC CHANGES IN T-CELLS ARE INVOLVED IN IMMUNOMETABOLISM, Atherosclerosis 331: E110-E110.
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- Groene, S.G.; Spekman, J.A.; Pas, A.B. te; Heijmans, B.T.; Haak, M.C.; Klink, J.M.M. van; Roest, A.A.W. & Lopriore, E. (2021), Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction, EClinicalMedicine 32.
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- Li, C.H.; Tobi, E.W.; Heijmans, B.T. & Lumey, L.H. (2020), Reply to 'Chinese famine and the diabetes mellitus epidemic'.
- Tilburg, J.; Slieker, R.C.; Suchiman, H.E.D.; Heath, A.; Heemst, D. van; Slagboom, P.E.; Gruijl, F.R. de; Gunn, D.A. & Heijmans, B.T. (2020), Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response, Epigenomics 12(7): 563-573.
- Hop, P.J.; Luijk, R.; Daxinger, L.; Iterson, M. van; Dekkers, K.F.; Jansen, R.; Meurs, J.B.J. van; Hoen, P.A.C. 't; Ikram, M.A.; Greevenbroek, M.M.J. van; Boomsma, D.I.; Slagboom, P.E.; Veldink, J.H.; Zwet, E.W. van; Heijmans, B.T. & BIOS Consortium (2020), Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference, Genome Biology 21(1).
- Li, C.H.; Tobi, E.W.; Heijmans, B.T. & Lumey, L.H. (2020), Reply to 'Early-life exposure to the Chinese Famine and subsequent T2DM'.
- Salgado, C.; Gruis, N.; Heijmans, B.T.; Oosting, J.; Doorn, R. van & BIOS Consortium (2020), Genome-wide analysis of constitutional DNA methylation in familial melanoma, Clinical Epigenetics 12(1).
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- Li, C.H.; Tobi, E.W.; Heijmans, B.T. & Lumey, L.H. (2019), The effect of the Chinese Famine on type 2 diabetes mellitus epidemics, Nature Reviews Endocrinology 15(6): 313-314.
- Jadhav, B.; Monajemi, R.; Gagalova, K.K.; Ho, D.; Draisma, H.H.M.; Wiel, M.A. van de; Franke, L.; Heijmans, B.T.; Meurs, J. van; Jansen, R.; Hoen, P.A.C. t; Sharp, A.J.; Kielbasa, S.M.; GoNL Consortium & BIOS Consortium (2019), RNA-Seq in 296 phased trios provides a high-resolution map of genomic imprinting, BMC Biology 17.
- Dekkers, K.F.; Neele, A.E.; Jukema, J.W.; Heijmans, B.T. & Winther, M.P.J. de (2019), Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites, Epigenetics and Chromatin 12.
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- Bell, C.G.; Lowe, R.; Adams, P.D.; Baccarelli, A.A.; Beck, S.; Bell, J.T.; Christensen, B.C.; Gladyshev, V.N.; Heijmans, B.T.; Horvath, S.; Ideker, T.; Issa, J.P.J.; Kelsey, K.T.; Marioni, R.E.; Reik, W.; Relton, C.L.; Schalkwyk, L.C.; Teschendorff, A.E.; Wagner, W.; Zhang, K. & Rakyan, V.K. (2019), DNA methylation aging clocks: challenges and recommendations, Genome Biology 20(1).
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- Rooij, J. van; Mandaviya, P.R.; Claringbould, A.; Felix, J.F.; Dongen, J. van; Jansen, R.; Franke, L.; Hoen, P.A.C. 't; Heijmans, B.; Meurs, J.B.J. van & BIOS Consortium (2019), Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies, Genome Biology 20(1).
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- Mandaviya, P.R.; Joehanes, R.; Brody, J.; Castillo-Fernandez, J.E.; Dekkers, K.F.; , A.N. do; Graff, M.; Hanninen, I.K.; Tanaka, T.; Jonge, E.A.L. de; Kiefte-de Jong, J.C.; Absher, D.M.; Aslibekyan, S.; Rijke, Y.B. de; Fornage, M.; Hernandez, D.G.; Hurme, M.A.; Ikram, M.A.; Jacques, P.F.; Justice, A.E.; Kiel, D.P.; Lemaitre, R.N.; Mendelson, M.M.; Mikkila, V.; Moore, A.Z.; Pallister, T.; Raitakari, O.T.; Schalkwijk, C.G.; Sha, J.; Slagboom, E.P.E.; Smith, C.E.; Stehouwer, C.D.A.; Tsai, P.C.; Uitterlinden, A.G.; Kallen, C.J.H. van der; Heemst, D. van; Arnett, D.K.; Bandinelli, S.; Bell, J.T.; Heijmans, B.T.; Lehtimaki, T.; Levy, D.; North, K.E.; Sotoodehnia, N.; Greevenbroek, M.M.J. van; Meurs, J.B.J. van; Heil, S.G.; BIOS Consortium; CHARGE Consortium Epigenetics & CHARGE Consortium Nutr Working Grp (2019), Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals, The American Journal of Clinical Nutrition 110(2): 437-450.
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- Hartman R., Siemelink M., Haitjema S., Luijk R., Dekkers K., Boltjes A., de Borst G. J., Heijmans B., Asselbergs F., Pasterkamp G., Van der Laan S. W. & den Ruijter H. (2019), AUTOSOMAL SEXUAL DIMORPHISM IN METHYLATION OF ADVANCED ATHEROSCLEROTIC CAROTID PLAQUES, Atherosclerosis 287: E66-E66.
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- Smit, R.A.J.; Jukema, J.W.; Postmus, I.; Ford, I.; Slagboom, P.E.; Heijmans, B.T.; Cessie, S. le & Trompet, S. (2018), Visit-to-visit lipid variability: Clinical significance, effects of lipid-lowering treatment, and (pharmaco) genetics, Journal of Clinical Lipidology 12(2): 266-276.
- Luijk, R.; Dekkers, K.F.; Iterson, M. van; Arindrarto, W.; Claringbould, A.; Hop, P.; Boomsma, D.I.; Duijn, C.M. van; Greevenbroek, M.M.J. van; Veldink, J.H.; Wijmenga, C.; Franke, L.; Hoend, P.A.C. 't; Jansen, R.; Meurs, J. van; Mei, H.L.; Slagboomi, P.E.; Heijmans, B.T.; Zwet, E.W. van & BIOS Consortium (2018), Genome-wide identification of directed gene networks using large-scale population genomics data, Nature Communications 9.
- Siemelink, M.A.; Laan, S.W. van der; Haitjema, S.; Koeverden, I.D. van; Schaap, J.; Wesseling, M.; Jager, S.C.A. de; Mokry, M.; Iterson, M. van; Dekkers, K.F.; Luijk, R.; Asl, H.F.; Michoel, T.; Bjorkegren, J.L.M.; Aavik, E.; Yla-Herttuala, S.; Borst, G.J. de; Asselbergs, F.W.; Azzouzi, H. el; Ruijter, H.M. den; Heijmans, B.T. & Pasterkamp, G. (2018), Smoking is Associated to DNA Methylation in Atherosclerotic Carotid Lesions, Circulation: Genomic and Precision Medicine 11(9).
- Tobi, E.W.; Heuvel, J. van den; Zwaan, B.J.; Lumey, L.H.; Heijmans, B.T. & Uller, T. (2018), Selective Survival of Embryos Can Explain DNA Methylation Signatures of Adverse Prenatal Environments, Cell Reports 25(10): 2660-+.
- Parmar, P.; Lowry, E.; Cugliari, G.; Suderman, M.; Wilson, R.; Karhunen, V.; Andrew, T.; Wiklund, P.; Wielscher, M.; Guarrera, S.; Teumer, A.; Lehne, B.; Milani, L.; Klein, N. de; Mishra, P.P.; Melton, P.E.; Mandaviya, P.R.; Kasela, S.; Nano, J.; Zhang, W.H.; Zhang, Y.; Uitterlinden, A.G.; Peters, A.; Schottker, B.; Gieger, C.; Anderson, D.; Boomsma, D.I.; Grabe, H.J.; Panico, S.; Veldink, J.H.; Meurs, J.B.J. van; Berg, L. van den; Beilin, L.J.; Franke, L.; Loh, M.; Greevenbroek, M.M.J. van; Nauck, M.; Kahonen, M.; Hurme, M.A.; Raitakari, O.T.; Franco, O.H.; Slagboom, P.E.; Harst, P. van der; Kunze, S.; Felix, S.B.; Zhang, T.; Chen, W.; Mori, T.A.; Bonnefond, A.; Heijmans, B.T.; Muka, T.; Kooner, J.S.; Fischer, K.; Waldenberger, M.; Froguel, P.; Huang, R.C.; Lehtimaki, T.; Rathmann, W.; Relton, C.L.; Matullo, G.; Brenner, H.; Verweij, N.; Li, S.X.; Chambers, J.C.; Jarvelin, M.R.; Sebert, S.; BIOS Consortium & GLOBAL Meth QTL (2018), Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults, EBioMedicine 38: 206-216.
- Luijk, R.; Wu, H.Y.; Ward-Caviness, C.K.; Hannon, E.; Carnero-Montoro, E.; Min, J.L.; Mandaviya, P.; Muller-Nurasyid, M.; Mei, H.; Maarel, S.M. van der; Relton, C.; Mill, J.; Waldenberger, M.; Bell, J.T.; Jansen, R.; Zhernakova, A.; Franke, L.; Hoen, P.A.C. 't; Boomsma, D.I.; Duijn, C.M. van; Greevenbroek, M.M.J. van; Veldink, J.H.; Wijmenga, C.; Meurs, J. van; Daxinger, L.; Slagboom, P.E.; Zwet, E.W. van; Heijmans, B.T. & BIOS Consortium (2018), Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation, Nature Communications 9.
- Jenny van Dongen, BIOS consortium, Marc Jan Bonder, Koen F. Dekkers, Michel G. Nivard, Maarten van Iterson, Gonneke Willemsen, Marian Beekman, Ashley van der Spek, Joyce van Meurs, Lude Franke, Bastiaan T. Heijmans, Cornelia van Duijn, P. Eline Slagboom & Dorret I. Boomsma (2018), DNA methylation signatures of educational attainment, npj Science of Learning 3(7).
- Tobi, E.W.; Slieker, R.C.; Luijk, R.; Dekkers, K.F.; Stein, A.D.; Xu, K.M.; Slagboom, P.E.; Zwet, E.W. van; Lumey, L.H.; Heijmans, B.T. & Biobank-Based Integrative Omics (2018), DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood, Science Advances 4(1).
- Wahl, A.; Kasela, S.; Carnero-Montoro, E.; Iterson, M. van; Stambuk, J.; Sharma, S.; Akker, E. van den; Klaric, L.; Benedetti, E.; Razdorov, G.; Trbojevic-Akmacic, I.; Vuckovic, F.; Ugrina, I.; Beekman, M.; Deelen, J.; Heemst, D. van; Heijmans, B.T.; Wuhrer, M.; Plomp, R.; Keser, T.; Simurina, M.; Pavic, T.; Gudelj, I.; Kristic, J.; Grallert, H.; Kunze, S.; Peters, A.; Bell, J.T.; Spector, T.D.; Milani, L.; Slagboom, P.E.; Lauc, G.; Gieger, C. & B I O S Consortium (2018), IgG glycosylation and DNA methylation are interconnected with smoking, BBA - General Subjects 1862(3): 637-648.
- Iterson, M. van; Cats, D.; Hop, P.; Heijmans, B.T. & BIOS Consortium (2018), omicsPrint: detection of data linkage errors in multiple omics studies, Bioinformatics 34(12): 2142-2143.
- Slieker, R.C.; Relton, C.L.; Gaunt, T.R.; Slagboom, P.E. & Heijmans, B.T. (2018), Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception, Epigenetics and Chromatin 11.
- Roost, M.S.; Slieker, R.C.; Bialecka, M.; Iperen, L. van; Fernandes, M.M.G.; He, N.N.; Suchiman, H.E.D.; Szuhai, K.; Carlotti, F.; Koning, E.J.P. de; Mummery, C.L.; Heijmans, B.T. & Lopes, S.M.C.D. (2017), DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells, Nature Communications 8.
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- Dongen, J. van; Willemsen, G.; Heijmans, B.T.; Neuteboom, J.; Kluft, C.; Jansen, R.; Penninx, B.W.J.; Slagboom, P.E.; Geus, E.J.C. de & Boomsma, D.I. (2015), Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins, International Journal of Obesity 39(6): 899-909.
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- Tobi, E.W.; Slieker, R.C.; Stein, A.D.; Suchiman, H.E.D.; Slagboom, P.E.; Zwet, E.W. van; Heijmans, B.T. & Lumey, L.H. (2015), Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome, International Journal of Epidemiology 44(4): 1211-1223.
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- Tan, Q.H.; Frost, M.; Heijmans, B.T.; Hjelmborg, J.V.; Tobi, E.W.; Christensen, K. & Christiansen, L. (2014), Epigenetic signature of birth weight discordance in adult twins, BMC Genomics 15.
- Akker, E.B. van den; Passtoors, W.M.; Jansen, R.; Zwet, E.W. van; Goeman, J.J.; Hulsman, M.; Emilsson, V.; Perola, M.; Willemsen, G.; Penninx, B.W.J.H.; Heijmans, B.T.; Maier, A.B.; Boomsma, D.I.; Kok, J.N.; Slagboom, P.E.; Reinders, M.J.T. & Beekman, M. (2014), Meta- analysis on blood transcriptomic studies identifies consistently coexpressed protein- protein interaction modules as robust markers of human aging, Aging Cell 13(2): 216-225.
- Almouzni, G.; Altucci, L.; Amati, B.; Ashley, N.; Baulcombe, D.; Beaujean, N.; Bock, C.; Bongcam-Rudloff, E.; Bousquet, J.; Braun, S.; Bressac-de Paillerets, B.; Bussemakers, M.; Clarke, L.; Conesa, A.; Estivill, X.; Fazeli, A.; Grgurevic, N.; Gut, I.; Heijmans, B.T.; Hermouet, S.; Houwing-Duistermaat, J.; Iacobucci, I.; Ilas, J.; Kandimalla, R.; Krauss-Etschmann, S.; Lasko, P.; Lehmann, S.; Lindroth, A.; Majdic, G.; Marcotte, E.; Martinelli, G.; Martinet, N.; Meyer, E.; Miceli, C.; Mills, K.; Moreno-Villanueva, M.; Morvan, G.; Nickel, D.; Niesler, B.; Nowacki, M.; Nowak, J.; Ossowski, S.; Pelizzola, M.; Pochet, R.; Potocnik, U.; Radwanska, M.; Raes, J.; Rattray, M.; Robinson, M.D.; Roelen, B.; Sauer, S.; Schinzer, D.; Slagboom, E.; Spector, T.; Stunnenberg, H.G.; Tiligada, E.; Torres-Padilla, M.E.; Tsonaka, R.; Soom, A. van; Vidakovic, M. & Widschwendter, M. (2014), Relationship between genome and epigenome - challenges and requirements for future research, BMC Genomics 15.
- Mil, N.H. van; Steegers-Theunissen, R.P.M.; Bouwland-Both, M.I.; Verbiest, M.M.P.J.; Rijlaarsdam, J.; Hofman, A.; Steegers, E.A.P.; Heijmans, B.T.; Jaddoe, V.W.V.; Verhulst, F.C.; Stolk, L.; Eilers, P.H.C.; Uitterlinden, A.G. & Tiemeier, H. (2014), DNA methylation profiles at birth and child ADHD symptoms.
- Deelen, J.; Beekman, M.; Uh, H.W.; Broer, L.; Ayers, K.L.; Tan, Q.; Kamatani, Y.; Bennet, A.M.; Tamm, R.; Trompet, S.; Guobjartsson, D.F.; Flachsbart, F.; Rose, G.; Viktorin, A.; Fischer, K.; Nygaard, M.; Cordell, H.J.; Crocco, P.; Akker, E.B. van den; Bohringer, S.; Helmer, Q.; Nelson, C.P.; Saunders, G.I.; Alver, M.; Andersen-Ranberg, K.; Breen, M.E.; Breggen, R. van der; Caliebe, A.; Capri, M.; Cevenini, E.; Collerton, J.C.; Dato, S.; Davies, K.; Ford, I.; Gampe, J.; Garagnani, P.; Geus, E.J.C. de; Harrow, J.; Heemst, D. van; Heijmans, B.T.; Heinsen, F.A.; Hottenga, J.J.; Hofman, A.; Jeune, B.; Jonsson, P.V.; Lathrop, M.; Lechner, D.; Martin-Ruiz, C.; Mcnerlan, S.E.; Mihailov, E.; Montesanto, A.; Mooijaart, S.P.; Murphy, A.; Nohr, E.A.; Paternoster, L.; Postmus, I.; Rivadeneira, F.; Ross, O.A.; Salvioli, S.; Sattar, N.; Schreiber, S.; Stefansson, H.; Stott, D.J.; Tiemeier, H.; Uitterlinden, A.G.; Westendorp, R.G.J.; Willemsen, G.; Samani, N.J.; Galan, P.; Sorensen, T.I.A.; Boomsma, D.I.; Jukema, J.W.; Rea, I.M.; Passarino, G.; Craen, A.J.M. de; Christensen, K.; Nebel, A.; Stefansson, K.; Metspalu, A.; Magnusson, P.; Blanche, H.; Christiansen, L.; Kirkwood, T.B.L.; Duijn, C.M. van; Franceschi, C.; Houwing-Duistermaat, J.J. & Slagboom, P.E. (2014), Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age, Human Molecular Genetics 23(16): 4420-4432.
- Iterson, M. van; Tobi, E.W.; Slieker, R.C.; Hollander, W. den; Luijk, R.; Slagboom, P.E. & Heijmans, B.T. (2014), MethylAid: visual and interactive quality control of large Illumina 450k datasets, Bioinformatics 30(23): 3435-3437.
- Tobi, E.W.; Goeman, J.J.; Monajemi, R.; Gu, H.C.; Putter, H.; Zhang, Y.J.; Slieker, R.C.; Stok, A.P.; Thijssen, P.E.; Muller, F.; Zwet, E.W. van; Bock, C.; Meissner, A.; Lumey, L.H.; Slagboom, P.E. & Heijmans, B.T. (2014), DNA methylation signatures link prenatal famine exposure to growth and metabolism, Nature Communications 5.
- Verschuren, J.J.W.; Trompet, S.; Deelen, J.; Stott, D.J.; Sattar, N.; Buckley, B.M.; Ford, I.; Heijmans, B.T.; Guchelaar, H.J.; Houwing-Duistermaat, J.J.; Slagboom, P.E. & Jukema, J.W. (2013), Non-Homologous End-Joining Pathway Associated with Occurrence of Myocardial Infarction: Gene Set Analysis of Genome-Wide Association Study Data, PLoS ONE 8(2).
- Mill, J. & Heijmans, B.T. (2013), From promises to practical strategies in epigenetic epidemiology, Nature Reviews Genetics 14(8): 585-594.
- Bouwland-Both, M.I.; Mil, N.H. van; Stolk, L.; Eilers, P.H.C.; Verbiest, M.M.P.J.; Heijmans, B.T.; Tiemeier, H.; Hofman, A.; Steegers, E.A.P.; Jaddoe, V.W.V. & Steegers-Theunissen, R.P.M. (2013), DNA Methylation of IGF2DMR and H19 Is Associated with Fetal and Infant Growth: The Generation R Study, PLoS ONE 8(12).
- Thijssen, P.E.; Tobi, E.W.; Balog, J.; Schouten, S.G.; Kremer, D.; Bouazzaoui, F. el; Henneman, P.; Putter, H.; Slagboom, P.E.; Heijmans, B.T. & Maarel, S.M. van der (2013), Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence Commonalities and differences between chromosomes, Epigenetics 8(5): 512-521.
- Slieker, R.C.; Bos, S.D.; Goeman, J.J.; Bovee, J.V.M.G.; Talens, R.P.; Breggen, R. van der; Suchiman, H.E.D.; Lameijer, E.W.; Putter, H.; Akker, E.B. van den; Zhang, Y.J.; Jukema, J.W.; Slagboom, P.E.; Meulenbelt, I. & Heijmans, B.T. (2013), Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array, Epigenetics and Chromatin 6.
- Obermann-Borst, S.A.; Eilers, P.H.C.; Tobi, E.W.; Jong, F.H. de; Slagboom, P.E.; Heijmans, B.T. & Steegers-Theunissen, R.P.M. (2013), Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children, Pediatric Research 74(3): 344-349.
- Verschuren, J.J.W.; Boden, H.; Wessels, J.A.M.; Hoeven, B.L. van der; Trompet, S.; Heijmans, B.T.; Putter, H.; Guchelaar, H.J.; Schalij, M.J. & Jukema, J.W. (2013), Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction, International Journal of Cardiology 167(6): 2882-2888.
- Verschuren, J.J.W.; Trompet, S.; Sampietro, M.L.; Heijmans, B.T.; Koch, W.; Kastrati, A.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Quax, P.H.A. & Jukema, J.W. (2013), Pathway Analysis Using Genome-Wide Association Study Data for Coronary Restenosis - A Potential Role for the PARVB Gene, PLoS ONE 8(8).
- Khan, T.A.; Shah, T.; Prieto, D.; Zhang, W.L.; Price, J.; Fowkes, G.R.; Cooper, J.; Talmud, P.J.; Humphries, S.E.; Sundstrom, J.; Hubacek, J.A.; Ebrahim, S.; Lawlor, D.A.; Ben-Shlomo, Y.; Abdollahi, M.R.; Slooter, A.J.C.; Szolnoki, Z.; Sandhu, M.; Wareham, N.; Frikke-Schmidt, R.; Tybjaerg-Hansen, A.; Fillenbaum, G.; Heijmans, B.T.; Katsuya, T.; Gromadzka, G.; Singleton, A.; Ferrucci, L.; Hardy, J.; Worrall, B.; Rich, S.S.; Matarin, M.; Whittaker, J.; Gaunt, T.R.; Whincup, P.; Morris, R.; Deanfield, J.; Donald, A.; Smith, G.D.; Kivimaki, M.; Kumari, M.; Smeeth, L.; Khaw, K.T.; Nalls, M.; Meschia, J.; Sun, K.; Hui, R.T.; Day, I.; Hingorani, A.D. & Casas, J.P. (2013), Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14 015 stroke cases and pooled analysis of primary biomarker data from up to 60 883 individuals, International Journal of Epidemiology 42(2): 475-492.
- Heijmans, B.T. & Mill, J. (2012), Commentary: The seven plagues of epigenetic epidemiology, International Journal of Epidemiology 41(1): 74-78.
- Talens, R.P.; Jukema, J.W.; Trompet, S.; Kremer, D.; Westendorp, R.G.J.; Lumey, L.H.; Sattar, N.; Putter, H.; Slagboom, P.E.; Heijmans, B.T. & PROSPER Grp (2012), Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction, International Journal of Epidemiology 41(1): 106-115.
- Tobi, E.W.; Slagboom, P.E.; Dongen, J. van; Kremer, D.; Stein, A.D.; Putter, H.; Heijmans, B.T. & Lumey, L.H. (2012), Prenatal Famine and Genetic Variation Are Independently and Additively Associated with DNA Methylation at Regulatory Loci within IGF2/H19, PLoS ONE 7(5): -.
- Talens, R.P.; Jukema, J.W.; Trompet, S.; Kremer, D.; Westendorp, R.G.J.; Lumey, L.H.; Sattar, N.; Putter, H.; Slagboom, P.E.; Heijmans, B.T. & PROSPER Grp (2012), Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction, International Journal of Epidemiology 41(1): 106-115.
- Verschuren, J.J.W.; Boden, H.; Wessels, J.A.M.; Hoeven, B.L. van der; Trompet, S.; Heijmans, B.T.; Putter, H.; Guchelaar, H.J.; Schalij, M.J. & Jukema, J.W. (2012), Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction, European Heart Journal 33: 516-516.
- Heijmans, B.T. & Mill, J. (2012), Commentary: The seven plagues of epigenetic epidemiology, International Journal of Epidemiology 41(1): 74-78.
- Lu, Y.C.; Vaarhorst, A.; Merry, A.H.H.; Dolle, M.E.T.; Hovenier, R.; Imholz, S.; Schouten, L.J.; Heijmans, B.T.; Muller, M.; Slagboom, P.E.; Brandt, P.A. van den; Gorgels, A.P.M.; Boer, J.M.A. & Feskens, E.J.M. (2012), Markers of Endogenous Desaturase Activity and Risk of Coronary Heart Disease in the CAREMA Cohort Study, PLoS ONE 7(7): -.
- Talens, R.P.; Christensen, K.; Putter, H.; Willemsen, G.; Christiansen, L.; Kremer, D.; Suchiman, H.E.D.; Slagboom, P.E.; Boomsma, D.I. & Heijmans, B.T. (2012), Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs, Aging Cell 11(4): 694-703.
- Vaarhorst, A.A.M.; Lu, Y.C.; Heijmans, B.T.; Dolle, M.E.T.; Bohringer, S.; Putter, H.; Imholz, S.; Merry, A.H.H.; Greevenbroek, M.M. van; Jukema, J.W.; Gorgels, A.P.M.; Brandt, P.A. van den; Muller, M.; Schouten, L.J.; Feskens, E.J.M.; Boer, J.M.A. & Slagboom, P.E. (2012), Literature-Based Genetic Risk Scores for Coronary Heart Disease The Cardiovascular Registry Maastricht (CAREMA) Prospective Cohort Study, Circulation: Cardiovascular Genetics 5(2): 202-209.
- Susser, E.; Kirkbride, J.B.; Heijmans, B.T.; Kresovich, J.K.; Lumey, L.H.; Stein, A.D.; Brenneis, D. & Ellison, P.T. (2012), Maternal Prenatal Nutrition and Health in Grandchildren and Subsequent Generations, ANNUAL REVIEW OF ANTHROPOLOGY, VOL 41 41: 577-610.
- Verschuren, J.J.W.; Trompet, S.; Postmus, I.; Sampietro, M.L.; Heijmans, B.T.; Houwing-Duistermaat, J.J.; Slagboom, P.E. & Jukema, J.W. (2012), Systematic Testing of Literature Reported Genetic Variation Associated with Coronary Restenosis: Results of the GENDER Study, PLoS ONE 7(8): -.
- Verschuren, J.J.W.; Trompet, S.; Postmus, I.; Sampietro, M.L.; Heijmans, B.T.; Houwing-Duistermaat, J.J.; Slagboom, E.P. & Jukema, J.W. (2012), Systematic testing of literature reported genetic variation associated with restenosis after percutaneous coronary intervention: results of the genetic determinants of restenosis study, European Heart Journal 33: 872-873.
- Obermann-Borst, S.A.; Heijmans, B.T.; Eilers, P.H.C.; Tobi, E.W.; Steegers, E.A.P.; Slagboom, P.E. & Steegers-Theunissen, R.P.M. (2012), Periconception maternal smoking and low education are associated with methylation of INSIGF in children at the age of 17 months, Journal of Developmental Origins of Health and Disease 3(5): 315-320.
- Tobi, E.W.; Heijmans, B.T.; Kremer, D.; Putter, H.; Delemarre-van de Waal, H.A.; Finken, M.J.J.; Wit, J.M. & Slagboom, P.E. (2011), DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age., Epigenetics 6(2).
- Slagboom, P.E.; Beekman, M.; Passtoors, W.M.; Deelen, J.; Vaarhorst, A.A.M.; Boer, J.M.; Akker, E.B. van den; Heemst, D. van; Craen, A.J.M. de; Maier, A.B.; Rozing, M.; Mooijaart, S.P.; Heijmans, B.T. & Westendorp, R.G.J. (2011), Genomics of human longevity., Philosophical Transactions B: Biological Sciences 366(1561): 35-42.
- Talens, R.P.; Jukema, J.W.; Trompet, S.; Kremer, D.; Westendorp, R.G.J.; Lumey, L.H.; Sattar, N.; Putter, H.; Slagboom, P.E.; Heijmans, B.T. & PROSPER Grp (2011), Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction., International Journal of Epidemiology.
- Deelen, J.; Beekman, M.; Uh, H.W.; Helmer, Q.; Kuningas, M.; Christiansen, L.; Kremer, D.; Breggen, R. van der; Suchiman, H.E.D.; Lakenberg, N.; Akker, E.B. van den; Passtoors, W.M.; Tiemeier, H.; Heemst, D. van; Craen, A.J. de; Rivadeneira, F.; Geus, E.J. de; Perola, M.; Ouderaa, F.J. van der; Gunn, D.A.; Boomsma, D.I.; Uitterlinden, A.G.; Christensen, K.; Duijn, C.M. van; Heijmans, B.T.; Houwing-Duistermaat, J.J.; Westendorp, R.G.J. & Slagboom, P.E. (2011), Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited, Aging Cell 10(4): 686-698.
- Slagboom, P.E.; Beekman, M.; Passtoors, W.M.; Deelen, J.; Vaarhorst, A.A.M.; Boer, J.M.; Akker, E.B. van den; Heemst, D. van; Craen, A.J.M. de; Maier, A.B.; Rozing, M.; Mooijaart, S.P.; Heijmans, B.T. & Westendorp, R.G.J. (2011), Genomics of human longevity, Philosophical Transactions B: Biological Sciences 366(1561): 35-42.
- Sampietro, M.L.; Trompet, S.; Verschuren, J.J.W.; Talens, R.P.; Deelen, J.; Heijmans, B.T.; Winter, R.J. de; Tio, R.A.; Doevendans, P.A.F.M.; Ganesh, S.K.; Nabel, E.G.; Westra, H.J.; Franke, L.; Akker, E.B. van den; Westendorp, R.G.J.; Zwinderman, A.H.; Kastrati, A.; Koch, W.; Slagboom, P.E.; Knijff, P. de & Jukema, J.W. (2011), A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention., Human Molecular Genetics 20(23): 4748-57.
- Lumey, L.H.; Vaarhorst, A.; Stein, A.D. & Heijmans, B. (2011), CAN ASSOCIATIONS BETWEEN PRENATAL NUTRITION AND BODY MASS INDEX BE EXPLAINED BY COMMON GENETIC VARIANTS? FINDINGS FROM THE DUTCH HUNGER WINTER FAMILIES STUDY, Journal of Epidemiology and Community Health 65: A76-A77.
- van den Akker EB, Verbruggen B, Heijmans BT, Beekman M, Kok JN, Slagboom PE & Reinders MJ (2011), Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis., Journal of Integrative Bioinformatics 8(2): 188.
- Pons, D.; Trompet, S.; Craen, A.J.M. de; Thijssen, P.E.; Quax, P.H.A.; Vries, M.R. de; Wierda, R.J.; Elsen, P.J. van den; Monraats, P.S.; Ewing, M.M.; Heijmans, B.T.; Slagboom, P.E.; Zwinderman, A.H.; Doevendans, P.A.F.M.; Tio, R.A.; Winter, R.J. de; Maat, M.P.M. de; Iakoubova, O.A.; Sattar, N.; Shepherd, J.; Westendorp, R.G.J.; Jukema, J.W.; PROSPER Study Grp; WOSCOPS Study Grp & GENDER Study Grp (2011), Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies, Heart 97(2): 143-150.
- Obermann-Borst, S.A.; Slagboom, P.E.; Eilers, P.H.C.; Tobi, E.W.; Jong, F.H. de; Steegers, E.A.P.; Heijmans, B.T. & Steegers-Theunissen, R.P.M. (2011), Duration of Breastfeeding Is Associated with the Methylation of LEP in Young Children, Journal of Developmental Origins of Health and Disease 2: S118-S119.
- Obermann-Borst, S.A.; Heijmans, B.T.; Slagboom, E.P.; Eilers, P.H.C.; Wildhagen, M.F.; Steegers, E.A.P. & Steegers-Theunissen, R.P.M. (2010), Periconception Maternal Risk Factors Affect DNA Methylation Profiles in Very Young Children, with Gender Effects., Reproductive Sciences 17(3): 223A-223A.
- Rozing, M.P.; Westendorp, R.G.J.; Craen, A.J.M. de; Frolich, M.; Heijmans, B.T.; Beekman, M.; Wijsman, C.; Mooijaart, S.P.; Blauw, G.J.; Slagboom, P.E.; Heemst, D. van & LLS Grp (2010), Low Serum Free Triiodothyronine Levels Mark Familial Longevity: The Leiden Longevity Study, Journals of Gerontology, Series A 65(4): 365-368.
- Talens, R.P.; Boomsma, D.I.; Tobi, E.W.; Kremer, D.; Jukema, J.W.; Willemsen, G.; Putter, H.; Slagboom, P.E. & Heijmans, B.T. (2010), Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology, FASEB Journal 24(9): 3135-3144.
- Vaarhorst, A.A.M.; Beekman, M.; Suchiman, E.H.D.; Heemst, D. van; Houwing-Duistermaat, J.J.; Westendorp, R.G.J.; Slagboom, P.E.; Heijmans, B.T.; Project Grp & Leiden Longevity Study LLS Grp (2010), Lipid metabolism in long-lived families: the Leiden Longevity Study., AGE.
- Beekman, M.; Nederstigt, C.; Suchiman, H.E.D.; Kremer, D.; Breggen, R. van der; Lakenberg, N.; Alemayehu, W.G.; Craen, A.J.M. de; Westendorp, R.G.J.; Boomsma, D.I.; Geus, E.J.C. de; Houwing-Duistermaat, J.J.; Heijmans, B.T. & Slagboom, P.E. (2010), Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity, Proceedings of the National Academy of Sciences 107(42): 18046-18049.
- Rozing, M.P.; Westendorp, R.G.J.; Craen, A.J.M. de; Frolich, M.; Goeij, M.C.M. de; Heijmans, B.T.; Beekman, M.; Wijsman, C.A.; Mooijaart, S.P.; Blauw, G.J.; Slagboom, P.E.; Heemst, D. van & Leiden Longevity Study Grp (2010), Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study, Journal of the American Geriatrics Society 58(3): 564-569.
- Pons D, de Vries FR, van den Elsen PJ, Heijmans BT, Quax PH & Jukema JW (2009), Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease, European Heart Journal 30(3): 266-277.
- Westendorp RGJ, van Heemst D, Rozing MP, Frolich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJM & Slagboom PE (2009), Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study, Journal of the American Geriatrics Society 57(9): 1634-1637.
- Rozing MP, Westendorp RG, Frölich M, de Craen AJ, Beekman M, Heijmans BT, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D & Group OB (2009), Human insulin/IGF-1 and familial longevity at middle age., Aging 1(8): 714-22.
- Steegers-Theunissen RP, Borst SA, Kremer D, Lindemans J, Siebel C, Steegers EA, Slagboom E & Heijmans BT (2009), Epigenetic Changes after Periconception Folic Acid Supplementation in Humans, Reproductive Sciences 16(3): 97A97A.
- Westendorp RG, van Heemst D, Rozing MP, Frölich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJ, Slagboom PE & (2009), Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study., Journal of the American Geriatrics Society 57(9): 1634-7.
- Pons D, de Vries FR, van den Elsen PJ, Heijmans BT, Quax PH & Jukema JW (2009), Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease., European Heart Journal 30(3): 266-77.
- Tobi EW, Lumey L, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE & Heijmans BT (2009), DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific, Human Molecular Genetics 18(21): 4046-4053.
- Heijmans BT, Tobi EW, Lumey LH & Slagboom PE (2009), The epigenome Archive of the prenatal environment, Epigenetics 4(8): 526-531.
- Tobi EW, Lumey LH, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE & Heijmans BT (2009), DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific., Human Molecular Genetics 18(21): 4046-53.
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- Heijmans BT, Tobi EW, Lumey LH & Slagboom PE (2009), The epigenome: archive of the prenatal environment., Epigenetics 4(8): 526-31.
- Steegers-Theunissen RP, Obermann-Borst SA, Kremer D, Lindemans J, Siebel C, Steegers EA, Slagboom PE & Heijmans BT (2009), Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child., PLoS ONE 4(11): e7845.
- Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, Susser ES, Slagboom PE & Lumey LH (2008), Persistent epigenetic differences associated with prenatal exposure to famine in humans, Proceedings of the National Academy of Sciences 105(44).
- Passtoors WM, Beekman M, Gunn D, Boer JM, Heijmans BT, Westendorp RGJ, Zwaan BJ & Slagboom PE (2008), Genomic studies in ageing research: the need to integrate genetic and gene expression approaches, Journal of Internal Medicine 263(2).
- Ghidey W, Stijnen T, Houwing-Duistermaat J, Heijmans B, Beekman M, Westendorp R, Slagboom E & van Houwelingen HC (2008), Predicting a binary outcome using SNPs: a case study on prediction of longevity, Genetic Epidemiology 32(7).
- Ghidey W, Stijnen T, Houwing-Duistermaat JJ, Heijmans BT, Beekman M, Westendorp RGJ, Slagboom PE & van Houwelingen HC (2008), Prediction models for SNP data, Annals of Human Genetics 72.
- Pons D, Trompet S, de Craen AJ, Monraats PS, de Maat MP, Zwinderman AH, Waltenberger J, Doevendans PA, Tio RA, de Winter RJ, Heijmans BT, Slagboom E, Westendorp RG & Jukema JW (2007), Genetic variation at the PCAF locus involved in epigenetic control associates with clinical endpoints in two large prospective studies, Circulation 116(16).
- Houwing-Duistermaat JJ, Helmer Q, Heijmans BT, Beekman M & Slagboom PE (2007), Selection of informative SNPs for sibling pair linkage analysis from large SNP arrays, Genetic Epidemiology 31(6).
- Pons D, Monraats PS, de Vries FR, de Maat MP, Zwinderman AH, de Winter RJ, Doevendans PAFM, Tio RA, Frants RR, Heijmans BT, Slagboom PE, van der Laarse A, van der Wall EE & Jukema JW (2007), Involvement of EPIgenetic variation in restenosis after PCI, Journal of the American College of Cardiology 49(9).
- Heijmans BT, Kremer D, Tobi EW, Boomsma DI & Slagboom PE (2007), Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus, Human Molecular Genetics 16(5).
- Whitfield JB, Dy V, McQuilty R, Zhu G, Montgomery GW, Ferreira MAR, Duffy DL, Neale MC, Heijmans BT, Heath AC & Martin NG (2007), Evidence of genetic effects on blood lead concentration, Environmental Health Perspectives 115(8).
- Slagboom PE, Heijmans BT, Beekman M & Meulenbelt I (2007), Molecular epidemiology, candidate genes versus genome-wide scans, Genes and Nutrition 2(1).
- Wessels JAM, de Vries-Bouwstra JK, Heijmans BT, Slagboom PE, Goekoop-Ruiterman YPM, Allaart CF, Kerstens PJSM, van Zeben D, Breedveld FC, Dijkmans BAC, Huizinga TWJ & Guchelaar HJ (2006), Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes, Arthritis and Rheumatism 54(4).
- Heijmans BT, Beekman M, Houwing-Duistermaat JJ, Cobain MR, Powell J, Blauw GJ, van der Ouderaa F, Westendorp RGJ & Slagboom PE (2006), Lipoprotein particle profiles mark familial and sporadic human longevity, PLoS Medicine 3(12): 2317-2323.
- van Dunne FM, de Craen AJM, Heijmans BT, Helmerhorst FM & Westendorp RGJ (2006), Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study, Human Reproduction 21(4).
- Heijmans BT, Beekman M, Putter H, Lakenberg N, van der Wijk HJ, Whitfield JB, Posthuma D, Pedersen NL, Martin NG, Boomsma DI & Slagboom PE (2005), Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions, European Journal of Human Genetics 13(10).
- Cornes BK, Medland SE, Ferreira MAR, Morley KI, Duffy DL, Heijmans BT, Montgomery GW & Martin NG (2005), Sex-limited genome-wide linkage scan for body mass index in an unselected sample of 933 Australian twin families, Twin Research and Human Genetics 8(6).
- Wessels JAM, de Vries-Bouwstra JK, Heijmans BT, Goekoop-Ruiterman YPM, Allaart CF, Kerstens PJ, van Zeben D, Breedveld FC, Dijkmans BAC, Huizinga TWJ & Guchelaar HJ (2005), Single nucleotide polymorphisms in genes coding for folate pathway enzymes are determinants for methotrexate efficacy in early rheumatoid arthritis, Arthritis and Rheumatism 52(9).
- Heemst, D. van; Beekman, M.; Mooijaart, S.P.; Heijmans, B.T.; Brandt, B.W.; Zwaan, B.J.; Slagboom, P.E. & Westendorp, R.G.J. (2005), Reduced insulin/IGF-1 signalling and human longevity, Aging Cell 4(2).
- Wessels JAM, De Vries-Bouwstra JK, Heijmans BT, Goekoop-Ruiterman YPM, Allaart CF, Kerstens PJS, Van Zeben D, Breedveld FC, Dijkmans BAC, Huizinga TWJ & Guchelaar H (2005), Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single nucleotide polymorphisms in genes coding for folate pathway enzymes, Annals of the Rheumatic Diseases 64.
- Kurreeman FAS, Schonkeren JJM, Heijmans BT, Toes REM & Huizinga TWJ (2004), Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level, Human Molecular Genetics 13(16).
- Beekman M, Posthuma D, Heijmans BT, Lakenberg N, Suchiman HED, Snieder H, de Knijff P, Frants RR, van Ommen GJB, Kluft C, Vogler GP, Slagboom PE & Boomsma DI (2004), Combined association and linkage analysis applied to the APOE locus, Genetic Epidemiology 26(4).
- van den Biggelaar AHJ, de Craen AJM, Gussekloo J, Huizinga TWJ, Heijmans BT, Frolich M, Kirkwood TBL & Westendorp RGJ (2004), Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming, FASEB Journal 18(6).
- Heijmans BT, Beem AL, Willemsen G, Posthuma D, Slagboom PE & Boomsma DI (2004), Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families, Twin Research 7(2).
- van den Biggelaar AHJ, Huizinga TWJ, de Craen AJM, Gussekloo J, Heijmans BT, Frolich M & Westendorp RGJ (2004), Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study, Experimental Gerontology 39(9).
- Heijmans BT, Boer JMA, Suchiman HED, Cornelisse CJ, Westendorp RGJ, Kromhout D, Feskens EJM & Slagboom PE (2003), A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer, Cancer Research 63(6).
- Beekman M, Heijmans BT, Martin NG, Whitfield JB, Pedersen NL, DeFaire U, Snieder H, Lakenberg N, Eka H, Suchiman D, de Knijff P, Frants RR, van Ommen GJB, Kluft C, Vogler GP, Boomsma DI & Slagboom PE (2003), Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population, European Journal of Human Genetics 11(11).
- Beekman M, Heijmans BT, Martin NG, Whitfield JB, Pedersen NL, DeFaire U, Snieder H, Lakenberg N, Knijff PC, Frants RR, van Ommen GJB, Kluft C, Vogler GR, Slagboom RE & Boomsma DI (2003), Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels, Twin Research 6(4).
- Heijmans BT, Westendorp RGJ, Droog S, Kluft C, Knook D & Slagboom PE (2002), Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort, Genes and Immunity 3(4).
- van Aken MO, de Craen AJM, Gussekloo J, Moghaddam PH, Vandenbroucke JP, Heijmans BT, Slagboom PE & Westendorp RGJ (2002), No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus Study, European Journal of Clinical Investigation 32(10).
- Heijmans BT, Beekman M, Martin NG, Whitfield JB, Pedersen NI, DeFaire U, Snieder H, Lakenberg N, de Knijff P, Frants RR, van Ommen GJE, Kluft C, Vogler GP, Slagboom PE & Boomsma DI (2002), No evidence for a locus influencing Lp(a) levels cn chromosome, American Journal of Human Genetics 71(4): 454-454.
- Beekman M, Heijmans BT, Martin NG, Pedersen NL, Whitfield JB, DeFaire U, van Baal GCM, Snieder H, Vogler GP, Slagboom PE & Boomsma DI (2002), Heritabilities of apolipoprotein and lipid levels in three countries, Twin Research 5(2).
- Heijmans BT, Slagboom PE, Gussekloo J, Droog S, Lagaay AM, Kluft C, Knook DL & Westendorp RGJ (2002), Association of APOE epsilon 2/epsilon 3/epsilon 4 and promoter gene variants with dementia but not cardiovascular mortality in old age, American Journal of Medical Genetics 107(3).
- Beekman M, Heijmans BT, Lakenberg N, Suchiman E, Vogler GP, Martin NG, Whitfield JB, Pedersen NL, Kluft C, van Ommen GJB, Frants RR, de Knijff P, Slagboom E & Boomsma DI (2001), Genome scan for quantitative traits involved in cardiovascular disease in three independent populations., Behavior Genetics 31(5): 447-447.
- Heijmans BT, Beekman M, Lakenberg N, Suchiman HED, Vogler GP, DeFaire U, Whitfield JB, de Knijff P, Kluft C, van Ommen GJB, Frants RR, Pedersen NL, Martin NG, Boomsma DI & Slagboom PE (2001), Genome scan for cardiovascular risk factors in three populations., American Journal of Human Genetics 69(4): 502-502.
- Feskens EJM, Heijmans BT, Slagboom PE & Kromhout D (2001), Insulin gene VNTR associated with type 2 diabetes: Interactions with age, body fatness and height, Diabetologia 44: A87-A87.
- Heijmans BT, Westendorp RGJ, Lagaay AM, Knook DL, Kluft C & Slagboom PE (2000), Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects.
- Heijmans BT, Westendorp RGJ & Slagboom PE (2000), Common gene variants, mortality and extreme longevity in humans, Experimental Gerontology 35(6-7).
- Slagboom PE, Heijmans BT, Beekman M, Westendorp RGJ & Meulenbelt I (2000), Genetics of human aging - The search for genes contributing to human longevity and diseases of the old.
- Heijmans BT, Westendorp RGJ, Knook DL, Kluft C & Slagboom PE (1999), Paraoxonase Met-55/Leu and Gln-192/Arg polymorphisms and the risk of mortality and fatal cardiovascular events in elderly subjects, Atherosclerosis 144: 18-18.
- Heiimans BT, Gussekloo J, Kluft C, Droog S, Lagaay AM, Knook DL, Westendorp RGJ & Slagboom PE (1999), Increased risk of mortality associated with a common mutation in the methylenetetrahydrofolate reductase gene (MTHFR), Zeitschrift f�r Gerontologie und Geriatrie 32(2): 146-146.
- Heijmans BT, Westendorp RGJ, Knook DL, Kluft C & Slagboom PE (1999), Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: Risk of mortality and fatal cardiovascular disease in an elderly population-based cohort, Journal of the American College of Cardiology 34(4): 1176-1183.
- Gussekloo J, Heijmans BT, Lagaay AM, Slagboom PE, Knook DL & Westendorp RGJ (1999), A common Methylenetetrahydrofolate Reductase polymorphism and cognitive decline in the oldest old., Zeitschrift f�r Gerontologie und Geriatrie 32(2): 120-120.