Catherijne Knibbe
Professor of Individualized drug treatment
- Name
- Prof.dr. C.A.J. Knibbe
- Telephone
- +31 71 527 6329
- c.knibbe@antoniusziekenhuis.nl
- ORCID iD
- 0000-0001-9893-4415
Catherijne Knibbe (Prof. Dr.) is Professor of Individualized Drug Treatment.
More information about Catherijne Knibbe
PhD Candidates
Postdocs
News
-
Anne van Rongen wins the Wayne A. Colburn Memorial Award -
How to determine medication dosages for premature babies -
Master's student Nicole ter Laak wins KNMP Studentenprijs 2023 -
Improving painkiller dosing in the clinic -
How do children's kidneys eliminate drugs? -
Virtual children help prevent withdrawal syndrome in real children -
How do you determine the right medicine dosage for a child? -
LACDR excels at the FIGON Dutch Medicine Days -
Bas Goulooze wins prestigious prize for research withdrawal symptoms in children -
Leiden PhD team in finals international pharmacological competition -
ZonMW awards funding for LACDR research project to develop novel biomarkers for bacterial infections -
Winning the 2016 Pharmaceutical Research Meritorious Manuscript Award -
PhD student Jantine Brussee wins second prize in PhD competition -
Margreke Brill wins TOP Publication Award NVKFB -
Extreme obesity demands tailor-made medication -
Elke Krekels receives Publication Award Dutch Society of Clinical Pharmacology -
Prof.dr. Catherijne Knibbe wins VIDI grant
Former PhD candidates
-
Aline Engbers -
Lu Chen -
Sjoerd de Hoogd -
Sinziana Cristea
-
Cornelis Smit
-
Sebastiaan Goulooze
-
Roeland Wassman
-
Yvette Lentferink
-
Jantine Brussee
-
Elisa Calvier
-
Rick Admiraal
-
Marloes van der Aa
-
Anne van Rongen
-
Margreke Brill
-
Soulmaz Fazeli Farsani
-
Roosmarijn de Cock
-
Laura van Gulik
-
Ibrahim Ince
-
Jeroen Diepstraten
-
Chenguang Wang
-
Elke Krekels
-
Simone van Kralingen
-
Imke Bartelink
-
Sabine Ahlers
-
Mariska Peeters
Profile
Catherijne Knibbe is clinical pharmacologist-hospital pharmacist in the St. Antonius Hospital in Nieuwegein/Utrecht and professor of Individualized Drug Treatment at the LACDR, Faculty of Science at Leiden University. At the Erasmus MC/Sophia Childrens Hospital, she holds a guest appointment for different collaborative pediatric clinical pharmacology projects.
Research and Clinical Activities
Knibbe leads the Quantitative Clinical Pharmacology group which focuses on the development and application of advanced computational techniques combining the statistical power of the Population approach with Physiologically-Based approaches, to predict the efficacy and safety of drugs and optimize dosing in special patient populations like such as (prematurely born) neonates or children, individuals with obesity or critically ill patients.
She has 25+ years of experience with (design of) pediatric clinical trials and adult clinical pharmacology studies both from investigator-initiated and drug development point of view, through her own clinical studies in the hospital, as co-investor of many pediatric clinical studies in the Sophia Childrens Hospital Rotterdam, and as vice-chair/member of the national IRB (CCMO) from 2011-2023.
In the St. Antonius hospital, Dr. Knibbe is consultant for the department of Intensive Care and Anesthesiology, is supervisor of the Clinical Pharmacology training program, is co-supervisor of the Hospital Pharmacy training program, and is member of the Daily Board of the Department of Clinical Pharmacy of the St. Antonius hospital.
She has supervised 26 PhD students, is currently co-supervising 9 PhD students and Post Docs, and is co-author of over 280 international peer-reviewed publications and contributions to books. She is a frequently invited speaker on national and international conferences.
Awards
Dr. Knibbe became a Fellow (FCP) of the American College of Clinical Pharmacology (ACCP) in 2019. For her research, she is supported by different grants, among which different ZonMw grants for dosing individualization in neonates, children and individuals with obesity, the prestigious Vidi grant in 2013 for her research project ‘From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling’ and a Veni grant in 2006. In 2009, she was awarded the ‘Huizenga penning’ by the Dutch Society of Hospital Pharmacy, which is an award presented to young Dutch hospital-pharmacists for scientific work of outstanding quality. In 2002, she received the Best PhD Thesis Award 2002 by the Dutch Society of Clinical Pharmacology and Biopharmacy. Many of her (former) PhD students have received awards for their work.
Other activities
Dr. Knibbe is an active member of the American College of Clinical Pharmacology (ACCP) where she serves in the Board of Regents, as co-chair of the Annual Meeting program committee 2024, and many other capacities. She is a member of Scientific Council of Kika, member of the national expert group on dosing guidelines for obese and bariatric surgery patients of the KNMP, has been member of the Central Committee of Research Involving Human Subjects (the 'CCMO') in The Hague from 2011-2023, member of the certification committee of the Dutch Society of Clinical Pharmacology & Biopharmacy from 2004-2023, has been chair of the Concilium Hospital Pharmacy of the Dutch Society of Hospital Pharmacy and member of the national Committee of State ‘Doek’ involving medical-ethical aspects of (non-therapeutic) research in children (2007-2009).
Professor of Individualized drug treatment
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Pharmacology
- Geersing T.H., Pourahmad D.M., Lodewijk F., Franssen E.J.F., Knibbe C.A.J. & Crul M. (2024), Analysis of production time and capacity for manual and robotic compounding scenarios for parenteral hazardous drugs, European Journal of Hospital Pharmacy 31: 352-357.
- Zwep L.B., Guo T., Nagler T.W., Knibbe C.A.J., Meulman J.J. & Hasselt J.G.C. van (2024), Virtual patient simulation using copula modeling, Clinical Pharmacology & Therapeutics 115(4): 795-804.
- Rhee K.P. van, Knibbe C.A.J., Linden P.D. van der & Brüggemann R.J.M. (2024), Patients with obesity should be recognised as a special patient population during drug development of antibacterial and antifungal agents: a Call to Action, Clinical Pharmacokinetics 63: 1-12.
- Rhee K.P. van, Brüggemann R.J.M., Roberts J.A., Sjövall F, Hest R.M. van, Elbers P.W.G., Abdulla A., Linden P.D. van der & Knibbe C.A.J. (2024), Pooled population pharmacokinetic analysis and dose recommendations for ciprofloxacin in intensive care unit patients with obesity, The Journal of Clinical Pharmacology : .
- Geersing T.H., Dogan D., Nejadnik M.R., Romeijn S., Knibbe C.A.J. & Crul M. (2024), Aggregate formation and antibody stability in infusion bags: the impact of manual and robotic compounding of monoclonal antibodies, Journal of Pharmaceutical Sciences 113(4): 1029-1037.
- Kingma J.S., Peeters N.W.L., Knibbe C.A.J., Agterof M.J., Derksen W.J.M., Burgers D.M.T. & Broek M.P.H. van den (2024), Clinical guidance for dosing and monitoring oral antihormonal drugs in patients with breast cancer after Roux-en-Y gastric bypass, Therapeutic Drug Monitoring 46(3): 404-409.
- Kingma J.S., Brenkman I.A.M., Broek M.P.H. van den, Bemt P.M.L.A. van den, Janssen K., Knibbe C.A.J. & Burgers D.M.T. (2024), Documentation of the patient characteristics morbid obesity and bariatric surgery in the hospital information system and the influence on the number of medication-related problems, The Annals of pharmacotherapy 58(10): 1020-1026.
- Stevens L.J., Steeg E. van de, Doppenberg J.B., Alwayn I.P.J., Knibbe C.A.J. & Dubbeld J. (2024), Ex vivo gut-hepato-biliary organ perfusion model to characterize oral absorption, gut-wall metabolism, pre-systemic hepatic metabolism and biliary excretion; application to midazolam, European Journal of Pharmaceutical Sciences 196: 106760.
- Guo Y., Guo T., Knibbe C.A.J., Zwep L.B. & Hasselt J.G.C. van (2024), Generation of realistic virtual adult populations using a model-based copula approach, Journal of Pharmacokinetics and Pharmacodynamics : .
- Zhang T., Calvier E.A.M., Krekels E.H.J. & Knibbe C.A.J. (2024), Impact of obesity on hepatic drug clearance: what are the influential variables?, AAPS Journal 26(3): 59.
- Zeilmaker-Roest G., Vries-Rink C. de, Rosmalen J. van, Dijk M. van, Wildt S.N. de, Knibbe C.A.J., Koomen E., Jansen N.J.G., Kneyber M.C.J., Maebe S., Berghe G. van den, Haghedooren R., Vlasselaers D., Bogers A.J.J.C., Tibboel D. & Wildschut E.D. (2024), Intermittent intravenous paracetamol versus continuous morphine in infants undergoing cardiothoracic surgery: a multi-center randomized controlled trial, Critical Care 28(1): 143.
- Tan Z., Völler S., Yin A., Rieborn A., Gelderblom A.J., Hulle T. van der, Knibbe C.A.J. & Moes D.J.A.R. (2024), Population pharmacokinetics of cabozantinib in metastatic renal cell carcinoma patients: towards drug expenses saving regimens, Clinical Pharmacokinetics 63(6): 857-869.
- Anker J.N. van den, Arya V., Knibbe C.A.J. & Zhou H. (2024), The vision for expanding the visibility of the journal of clinical pharmacology: meet the new editor-in-chief and the 3 new associate editors!, The Journal of Clinical Pharmacology 64(1): 7-9.
- Wu Y., Allegaert K., Flint R.B., Goulooze S.C., Valitalo P.A.J., Hoog M. de, Mulla H., Sherwin C.M.T., Simons S.H. P., Krekels E.H.J., Knibbe C.A.J. & Völler S. (2024), When will the glomerular filtration rate in former preterm neonates catch up with their term peers?, Pharmaceutical Research 41(4): 637-649.
- Chen L., Krekels E.H.J., Heijnen A.R., Knibbe C.A.J. & Brüggemann R.J. (2023), An integrated population pharmacokinetic analysis for posaconazole oral suspension, delayed-release tablet, and intravenous infusion in healthy volunteers, Drugs 83: 75-86.
- Stevens L.J., Dubbeld J., Doppenberg J.B., Hoek B. van, Menke A.L., Donkers J.M., Alsharaa A., Vries A.de, Vaes W.H.J., Knibbe C.A.J., Steeg E. van de & Alwayn I.P.J. (2023), Novel explanted human liver model to assess hepatic extraction, biliary excretion and transporter function, Clinical Pharmacology & Therapeutics 114(1): 137-147.
- Zhang T., Smit C., Sherwin C.M.T., Knibbe C.A.J. & Krekels E.H.J. (2023), Vancomycin clearance in obese adults is not predictive of clearance in obese adolescents, Clinical Pharmacokinetics 62(5): 749-759.
- Burger D.M., Le Comte M., Smolders E.J., Jacobs T.G., Heine R. Ter, Knibbe C.A.J. & Pirmohamed M. (2023), What the product label does not tell you about drug–drug interaction management: time for a re‐appraisal, The Journal of Clinical Pharmacology 63(11): 1181-1185.
- Lau C., Kesteren C. van, Smeenk R., Huitema A. & Knibbe C.A.J. (2023), Impact of bariatric surgery in the short and long term: a need for time-dependent dosing of drugs, Obesity Surgery 33: 3266-3302.
- Wu Y., Völler S., Krekels E.H.J., Roofthooft D.W.E., Simons S.H.P., Tibboel D., Flint R.B. & Knibbe C.A.J. (2023), Maturation of paracetamol elimination routes in preterm neonates born below 32 weeks of gestation, Pharmaceutical Research 40(9): 2155-2166.
- Bruijn C. de, Hamming G.A.C., Knibbe C.A.J., Tromp E., Benninga M.A. & Vlieger A.M. (2023), Teenagers’ and parental individual needs for side effects information and the influence of nocebo effect education, Patient Education and Counseling 108: 107587.
- Wu Y., Völler S., Flint R.B., Simons S.H.P., Allegaert K., Fellman V. & Knibbe C.A.J. (2022), Pre- and postnatal maturation are important for fentanyl exposure in preterm and term newborns: a pooled population pharmacokinetic study, Clinical Pharmacokinetics 61: 401-412.
- Arends B.C., Blussé van Oud-Alblas H.J., Vernooij L.M., Verwijmeren L., Biesma D.H., Knibbe C.A.J., Noordzij P.G. & Dongen E.P.A. van (2022), The association of polypharmacy with functional decline in elderly patients undergoing cardiac surgery, British Journal of Clinical Pharmacology 88(5): 2372-2379.
- Rongen A. van, Krekels E.H.J., Calvier E.A.M., Wildt S.N. de, Vermeulen A. & Knibbe C.A.J. (2022), An update on the use of allometric and other scaling methods to scale drug clearance in children: towards decision tables, Expert Opinion on Drug Metabolism & Toxicology 18(2): 99-113.
- Rhee K.P. van, Smit C., Wasmann R.E., Linden P.D. van der, Wiezer R., Dongen E.P. A. van, Krekels E.H.J., Brüggemann R.J.M. & Knibbe C.A.J. (2022), Ciprofloxacin pharmacokinetics after oral and intravenous administration in (morbidly) obese and non-obese individuals: a prospective clinical study, Clinical Pharmacokinetics 61(8): 1167-1175.
- Broek M.P.H. van den, Verschueren M.V. & Knibbe C.A.J. (2022), Critical appraisal of evidence for anti-Xa monitoring and dosing of low-molecular-weight heparin in renal insufficiency, Expert Review of Clinical Pharmacology 15(10): 1155-1163.
- Zhang T., Krekels E.H.J., Smit C. & Knibbe C.A.J. (2022), Drug pharmacokinetics in the obese population: challenging common assumptions on predictors of obesity-related parameter changes, Expert Opinion on Drug Metabolism & Toxicology 18(10): 657-674.
- Rhee K.P. van, Vroom S.L. de, Hest R.M. van, Linden P.D. van der, Tonino S.H., Molendijk E., Mathot R.A.A., Blijlevens N.M.A., Knibbe C.A.J., Bruggemann R.J.M. & Geerlings S.E. (2022), Impact of mucositis on oral bioavailability and systemic exposure of ciprofloxacin Gram-negative infection prophylaxis in patients with haematological malignancies, Journal of Antimicrobial Chemotherapy 77(11): 3069-3076.
- Engbers A.G.J., Flint R.B., Völler S., Reiss I., Liem K.D., Alffenaar J.W.C., Tibboel D., Simons S., Knibbe C.A.J. & Bruggemann R.J. (2022), Optimisation of fluconazole therapy for the treatment of invasive candidiasis in preterm infants, Archives of disease in childhood 107(4): 400-406.
- Wu Y.J., Allegaert K., Flint R.B., Simons S.H.P., Krekels E.H.J., Knibbe C.A.J. & Völler S. (2022), Prediction of glomerular filtration rate maturation across preterm and term neonates and young infants using inulin as marker, AAPS Journal 24(2): 38.
- Engbers A.G.J., Völler S., Flint R.B., Goulooze S.C., Klerk J. de, Krekels E.H.J., Dijk M. van, Willemsen S.P., Reiss I.K.M., Knibbe C.A.J. & Simons S.H.P. (2022), The effect of ibuprofen exposure and patient characteristics on the closure of the patent Ductus Arteriosus in preterm infants, Clinical Pharmacology & Therapeutics 112(2): 307-315.
- Chen L., Rhee K.P. van, Wasmann R.E., Krekels E.H.J., Wiezer M.J., Dongen E.P.A., Verweij P.E., Linden P.D., Bruggemann R.J. & Knibbe C.A.J. (2022), Total bodyweight and sex both drive pharmacokinetic variability of fluconazole in obese adults, Journal of Antimicrobial Chemotherapy 77(8): 2217-2226.
- Bouazza N., Dokoumetzidis A., Knibbe C.A.J., Wildt S.N. de, Ambery C., Cock P.A. de, Gasthuys E., Foissac F., Urien S., Hamberg A.K., Poggesi I., Zhao W., Vermeulen A., Standing J.F. & Tréluyer J.M. (2022), General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children, British Journal of Clinical Pharmacology 88(12): 4985-4996.
- Smit C., Engbers A.G.J., Samiee-Zafarghandy S., Donge T. van, Simons S.H.P., Flint R.B., Pfister M., Knibbe C.A.J. & Anker J.N. van den (2022), Oral ibuprofen is more effective than intravenous ibuprofen for closure of a patent ductus arteriosus: can pharmacokinetic modeling help us to understand why?, Neonatology : 1-9.
- Hartman S.J.F., Upadhyay P.J., Mathôt R.A.A., Flier M. van der, Schreuder M.F., Brüggeman R.J., Knibbe C.A.J. & Wildt S.N. de (2022), Population pharmacokinetics of intravenous cefotaxime indicates that higher doses are required for critically ill children, Journal of Antimicrobial Chemotherapy 77(6): 1725-1732.
- Braak W.G. van, Ponten J.E.H., Loozen C.S., Schots J.P.M., Geloven A.A.W. van, Donkervoort S.C., Nieuwenhuijzen G.A.P., Besselink M.G., Heek T.N.T., Reuver P.R., Vlaminckx B., Kelder J.C., Knibbe C.A.J., Santvoort H.C. & Boerma D. (2022), Antibiotic prophylaxis for acute cholecystectomy: PEANUTS II multicentre randomized non-inferiority clinical trial, British Journal of Surgery 109(3): 267-273.
- Groen B.D. van, Krekels E.H.J., Mooij M.G. Duijn E. van Vaes W.H.J., Windhorst A.D.,Rosmalen J. Hartman S.J.F., Hendrikse N.H., Koch B.C.P., Allegaert K., Tibboel D., Knibbe C.A.J. & Wildt S.N. (2021), The oral bioavailability and metabolism of midazolam in stable critically ill children: A pharmacokinetic microtracing study, Clinical Pharmacology & Therapeutics 109(1): 140-149.
- Flint R.B., Simons S.H.P., Andriessen P., Liem K.D., Degraeuwe P.L.J., Reiss I.K.M., Ter Heine R., Engbers A.G.J., Koch B.C.P., Groot R. de, Burger D.M., Knibbe C.A..J. & Völler S. (2021), The bioavailability and maturing clearance of doxapram in preterm infants, Pediatric Research 89: 1268-1277.
- Groen B.D. van, Pilla Reddy V., Badée J., Olivares-Morales A., Johnson T.N., Nicolaï J., Annaert P., Smits A., Wildt S.N. de, Knibbe C.A.J. & Zwart L. de (2021), Pediatric pharmacokinetics and dose predictions: a report of a satellite meeting to the 10th juvenile toxicity symposium, Clinical and Translational Science 14(1): 29-35.
- Goulooze S.C., Krekels E.H.J., Saleh M.A.A.E.W., Ahlers S.J., Valitalo P.A.J., Dongen E.P. van, Schaik R.H. van, Hankemeier T., Tibboel D. & Knibbe C.A.J. (2021), Predicting unacceptable pain in cardiac surgery patients receiving morphine maintenance and rescue doses: a model-based pharmacokinetic-pharmacodynamic analysis, Anesthesia and Analgesia 132(3): 726-734.
- Valkenburg A.J., Goulooze S.C., Breatnach C.V., Mathôt R.A.A., Tibboel D., Dijk M. van, Knibbe C.A.J. & Peeters M.Y.M. (2021), Sedation with midazolam after cardiac surgery in children with and without Down syndrome: a pharmacokinetic-pharmacodynamic study, Pediatric Critical Care Medicine 22(4): e259-e269.
- Hartman S.J.F., Upadhyay P.J., Hagedoorn N.N., Mathot R.A.A., Moll H.A., Flier M. van der, Schreuder M.F., Bruggemann R.J., Knibbe C.A. & Wildt S.N. (2021), Current ceftriaxone dose recommendations are adequate for most critically ill children: results of a population pharmacokinetic modeling and simulation study, Clinical Pharmacokinetics 60: 1361-1372.
- Smit C., Goulooze S.C., Bruggemann R.J.M., Sherwin C.M. & Knibbe C.A.J. (2021), Dosing recommendations for vancomycin in children and adolescents with varying levels of obesity and renal dysfunction: a population pharmacokinetic study in 1892 children aged 1-18 years, AAPS Journal 23(3): 53.
- Cristea S., Krekels E.H.J., Allegaert K., Paepe P. de, Jaeger A. de, Cock P. de & Knibbe C.A.J. (2021), Estimation of ontogeny functions for renal transporters using a combined population pharmacokinetic and physiology-based pharmacokinetic approach: application to OAT1,3, AAPS Journal 23(3): 65.
- Hoogd S. de, Goulooze S.C., Valkenburg A.J., Krekels E.H.J., Dijk M. van, Tibboel D. & Knibbe C.A.J. (2021), Postoperative breakthrough pain in paediatric cardiac surgery not reduced by increased morphine concentrations, Pediatric Research 90: 1201-1206.
- Engbers A.G.J., Voller S., Poets C.F., Knibbe C.A.J., Reiss I.K.M., Koch B.C.P., Flint R.B. & Simons S.H.P. (2021), The pharmacokinetics of caffeine in preterm newborns: no influence of doxapram but important maturation with age, Neonatology 118(1): 106-113.
- Goulooze S.C., Ista E., Dijk M. van, Tibboel D., Krekels E.H.J. & Knibbe C.A.J. (2021), Towards evidence-based weaning: a mechanism-based pharmacometric model to characterize iatrogenic withdrawal syndrome in critically ill children, AAPS Journal 23(4): 71.
- Voller S., Flint R.B., Simons S.H.P. & Knibbe C.A.J. (2021), Comment on: "Preterm Physiologically Based Pharmacokinetic Model, Part I and Part II", Clinical Pharmacokinetics 60: 677-679.
- Keij F.M., Koch B.E.V., Lozano Vigario F., Simons S.H.P., Hasselt J.G.C. van, Knibbe C.A.J., Spaink H.P., Reiss I.K.M. & Krekels E.H.J. (2021), Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsis, Journal of Clinical and Translational Science 5(1): e140.
- Stevens L.J., Zhu A.Z.X., Chothe P.P., Chowdhury S.K., Donkers J.M., Vaes W.H.J., Knibbe C.A.J., Alwayn I.P.J. & Steeg E. van de (2021), Evaluation of normothermic machine perfusion of porcine livers as a novel preclinical model to predict biliary clearance and transporter-mediated drug-drug interactions using statins, Drug Metabolism and Disposition 49(9): 780-789.
- Upadhyay P., Vet N.J., Goulooze S.C., Krekels E.H.J., Wildt S.N. de & Knibbe C.A.J. (2021), Midazolam infusion and disease severity affect the level of sedation in children: a parametric time-to-event analysis, Pharmaceutical Research 38: 1711-1720.
- Kingma J.S., Burgers D.M.T., Monpellier V.M., Wiezer M.J., Oud-Alblas H.J.B. van, Vaughns J.D., Sherwin C.M.T. & Knibbe C.A.J. (2021), Oral drug dosing following bariatric surgery: general concepts and specific dosing advice, British Journal of Clinical Pharmacology 87(12): 4563-4579.
- Hartman S., Upadhyay P., Hagedoorn N., Krekels E.H.J., Mathot R., Moll H., Flier M. van der, Schreuder M., Bruggemann R., Knibbe C.A.J. & Wildt S. de (2021), Population pharmacokinetics of ceftriaxone in critically ill children, Critical Care Medicine 49(1): 425.
- Goulooze S.C., Kluis T. de, Dijk M. van, Ceelie I., Wildt S.N. de, Tibboel D., Krekels E.H.J. & Knibbe C.A.J. (2021), Quantifying the pharmacodynamics of morphine in the treatment of postoperative pain in preverbal children, The Journal of Clinical Pharmacology 62(1): 99-109.
- Goulooze S.C., Zwep L.B., Vogt J.E., Krekels E.H.J., Hankemeier T., Anker J.N. van den & Knibbe C.A.J. (2020), Beyond the randomized clinical trial: innovative data science to close the pediatric evidence gap, Clinical Pharmacology & Therapeutics 107(4): 786-795.
- Vet N.J., Winter B.C.M. de, Koninckx M., Boeschoten S.A., Boehmer A.L.M., Verhallen J.T., Plötz F.B., Vaessen-Verberne A.A., Nagel B.C.H. van der, Knibbe C.A.J., Buysse C.M.P., Wildt S.N. de, Koch B.C.P. & Hoog M. de (2020), Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus, Clinical Pharmacokinetics 59: 257-264.
- Wasmann R.E., Smit C., Dongen E.P.H. van, Wiezer R.M.J., Adler-Moore J., Beer Y.M. de, Burger D.M., Knibbe C.A.J. & Bruggemann R.J.M. (2020), Fixed dosing of liposomal Amphotericin B in morbidly obese individuals, Clinical Infectious Diseases 70(10): 2213-2215.
- Smit C., Peeters M.Y.M., Anker J.N. van den & Knibbe C.A.J. (2020), Chloroquine for SARS-CoV-2: implications of its unique pharmacokinetic and safety properties, Clinical Pharmacokinetics 59: 659-669.
- Bestebreurtje P., Roeleveld N., Knibbe C.A.J., Sorge A.A. van, Plotz F.B. & Wildt S.N. de (2020), Development and stability study of an omeprazole suppository for infants, European Journal of Drug Metabolism and Pharmacokinetics 45: 627-633.
- Engbers A.G.J., Flint R.B., Voller S., Klerk J.C.A., Reiss I.K.M., Andriessen P., Liem K.D., Degraeuwe P.L.J., Croubels S., Millecam J., Allegaert K., Simons S.H.P. & Knibbe C.A.J. (2020), Enantiomer specific pharmacokinetics of ibuprofen in preterm neonates with patent ductus arteriosus, British Journal of Clinical Pharmacology 86(10): 2028-2039.
- Valkenburg A.J., Goulooze S.C., Ng C.Y., Breatnach C.V., Tibboel D., Dijk M. van, Knibbe C.A.J. & Krekels E.H.J. (2020), Exploring the relationship between morphine concentration and oversedation in children after cardiac surgery, The Journal of Clinical Pharmacology 60(9): 1231-1236.
- Wasmann R.E., Smit C., Donselaar M.H. van, Dongen E.P.A. van, Wiezer R.M.J., Verweij P.E., Burger D.M., Knibbe C.A.J. & Brüggemann R.J.M. (2020), Implications for IV posaconazole dosing in the era of obesity, Journal of Antimicrobial Chemotherapy 75(4): 1006-1013.
- Matic M., Hoogd S. de, Wildt S.N. de, Tibboel D., Knibbe C.A.J. & Schaik R.H. (2020), OPRM1 and COMT polymorphisms: implications on postoperative acute, chronic and experimental pain after cardiac surgery, Pharmacogenomics 21(3): 181-193.
- Stevens L., Dubbeld J., Doppenberg J., Erpelinck S., Knibbe C.A.J., Alwayn I. & Steeg E. van de (2020), Pharmacokinetic application of normothermic perfused ex vivo porcine and diseased human livers, Drug Metabolism and Pharmacokinetics 35(1): S47-S47.
- Poppe J.A., Weteringen W. van, Sebek L.L.G., Knibbe C.A.J., Reiss I.K.M., Simons S.H.P. & Flint R.B. (2020), Precision dosing of doxapram in preterm infants using continuous pharmacodynamic data and model-based pharmacokinetics: an illustrative case series, Frontiers in Pharmacology 11: 665.
- Michalickova D., Pokorna P., Tibboel D., Slanar O. Knibbe C.A.J. & Krekels E.H.J. (2020), Rapid increase in clearance of phenobarbital in neonates on extracorporeal membrane oxygenation: A pilot retrospective population pharmacokinetic analysis, Pediatric Critical Care Medicine 21(9): E707-E715.
- Bestebreurtje P., Koning B.A.E. de, Roeleveld N., Knibbe C.A.J., Tibboel D. Groen B.D. van, Ven C.P. van de, Plötz F.B. & Wildt S.N. de (2020), Rectal omeprazole in infants with gastroesophageal reflux disease: a randomized pilot trial, European Journal of Drug Metabolism and Pharmacokinetics 45: 635-643.
- Cristea S., Krekels E.H.J., Rostami-Hodjegan A., Allegaert K. & Knibbe C.A.J. (2020), The influence of drug properties and ontogeny of transporters on pediatric renal clearance through glomerular filtration and active secretion: a simulation-based study, AAPS Journal 22(4): 87.
- Cristea S., Krekels E.H.J., Allegaert K. & Knibbe C.A.J. (2020), The predictive value of glomerular filtration rate-based scaling of pediatric clearance and doses for drugs eliminated by glomerular filtration with varying protein-binding properties, Clinical Pharmacokinetics 59: 1291-1301.
- Smit C., Wasmann R.E., Wiezer M.J., Dongen H.P.A. van, Mouton J.W., Brüggemann R.J.M. & Knibbe C.A.J. (2020), Correction to: Tobramycin clearance is best described by renal function estimates in obese and nonobese Individuals: results of a prospective rich sampling pharmacokinetic study, Pharmaceutical Research 37: 32.
- Stevens L.J., Donkers J.M., Dubbeld J., Vaes W.H.J., Knibbe C.A.J., Alwayn I.P.J. & Steeg E.van de (2020), Towards humanex vivoorgan perfusion models to elucidate drug pharmacokinetics in health and disease, Drug Metabolism Reviews 52(3): 438-454.
- Smit C., Schip A.M. van, Dongen E.P.A. van, Bruggemann R.J.M., Becker M.L. & Knibbe C.A.J. (2020), Dose recommendations for gentamicin in the real-world obese population with varying body weight and renal (dys)function, Journal of Antimicrobial Chemotherapy 75(11): 3286-3292.
- Chen L., Krekels E.H.J., Verweij P.E., Buil J.B., Knibbe C.A.J. & Brüggemann R.J.M. (2020), Pharmacokinetics and pharmacodynamics of posaconazole, Drugs 80(7): 671-695.
- Krekels E.H.J., Calvier E.A.M., Graaf P.H. van der & Knibbe C.A.J. (2019), Children Are Not Small Adults, but Can We Treat Them As Such?, CPT: Pharmacometrics and Systems Pharmacology 8(1): 34-38.
- Lentferink Y.E., Kromwijk L.A.J., Aa M.P. van der, Knibbe C.A.J. & Vorst M.M.J. van der (2019), Increased Arterial Stiffness in Adolescents With Obesity, Global Pediatric Health 6: 1-8.
- Lentferink Y.E., Boogaart N.E., Balemans W.A.F., Knibbe C.A.J. & Vorst M.M.J. van der (2019), Asthma medication in children who are overweight/obese: Justified treatment?, BMC Pediatrics 19: 148.
- Kleiber N., Calvier E., Mooij M.G., Krekels E.H.J., Vaes W.H.J., Tibboel D., Knibbe C.A.J. & Wildt S.N. de (2019), Enteral acetaminophen bioavailability in pediatric intensive care patients determined with an oral microtracer and pharmacokinetic modeling to pptimize dosing, Critical Care Medicine 47(12): e975-e983.
- Brussee J.M., Krekels E.H.J., Calvier E.A.M., Palic S., Rostami-Hodjegan A., Danhof M., Barrett J.S., Wildt S.N. de & Knibbe C.A.J. (2019), A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children, AAPS Journal 21(5): 81.
- Groen B.D. van, Vaes W.H., Park B.K., Krekels E.H.J., Duijn E. van, Körgvee L.-T., Maruszak W., Grynkiewicz G., Garner R.C., Knibbe C.A.J., Tibboel D., Wildt S.N. de & Turner M.A. (2019), Dose‐linearity of the pharmacokinetics of an intravenous [14C]midazolam microdose in children, British Journal of Clinical Pharmacology 85(10): 2332-2340.
- Cristea S., Allegaert K., Falcao A.C., Falcao F., Silva R., Smits A., Knibbe C.A.J. & Krekels E.H.J. (2019), Larger Dose Reductions of Vancomycin Required in Neonates with Patent Ductus Arteriosus Receiving Indomethacin versus Ibuprofen, Antimicrobial Agents and Chemotherapy 63(8): e00853.
- Calvier E.A.M., Krekels E.H.J., Johnson T.N., Rostami-Hodjegan A., Tibboel D. & Knibbe C.A.J. (2019), Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method, AAPS Journal 21(3): 38.
- Mian R., Valkenburg A.J., Allegaert K., Koch B.C.P., Breatnach C.V., Knibbe C.A.J., Tibboel D. & Krekels E.H.J. (2019), Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass, The Journal of Clinical Pharmacology 59(6): 847-855.
- Smit C., Wasmann R.E., Goulooze S.C., Wiezer M.J., Dongen E.P.A. van, Mouton J.W., Brüggemann R.J.M. & Knibbe C.A.J. (2019), Population pharmacokinetics of vancomycin in obesity: finding the optimal dose for (morbidly) obese individuals, British Journal of Clinical Pharmacology 86(2): 303-317.
- Goulooze S.C., Ista E., Dijk M. van, Hankemeier T., Tibboel D., Knibbe C.A.J. & Krekels E.H.J. (2019), Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms, CPT: Pharmacometrics and Systems Pharmacology 8(12): 904-912.
- Smit C., Wasmann R.E., Goulooze S.C., Hazebroek E.J., Dongen E.P.A. van, Burgers D.M.T., Mouton J.W., Brüggemann R.J.M. & Knibbe C.A.J. (2019), A Prospective Clinical Study Characterizing the Influence of Morbid Obesity on the Pharmacokinetics of Gentamicin: Towards Individualized Dosing in Obese Patients, Clinical Pharmacokinetics 58(10): 1333-1343.
- Admiraal R., Jol-Van der Zijde C.M., Silva J.M.F., Knibbe C.A.J., Lankester A.C., Boelens J.J., Hale G., Etuk A., Wilson M., Adams S., Veys P., Kesteren C. van & Bredius R.G.M. (2019), Population Pharmacokinetics of Alemtuzumab (Campath) in Pediatric Hematopoietic Cell Transplantation: Towards Individualized Dosing to Improve Outcome, Clinical Pharmacokinetics 58(12): 1609-1620.
- Ollivier C., Thomson A., Manolis E., Blake K., Karlsson K.E., Knibbe C.A.J., Pons G. & Hemmings R. (2019), Commentary on the EMA Reflection Paper on the use of extrapolation in the development of medicines for paediatrics, British Journal of Clinical Pharmacology 85(4): 659-668.
- Blussé van Oud-Alblas H.J., Brill M.J.E., Peeters M.Y.M., Tibboel D., Danhof M. & Knibbe C.A.J. (2019), Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints, BMC Anesthesiology 19: 15.
- Lamminsalo M., Piirainen P., Kokki H., Knibbe C.A.J., Ranta V.P., Valitalo P.A.J. & Kokki M. (2019), Population pharmacokinetics of oxycodone in plasma and cerebrospinal fluid after epidural and intravenous administration, Expert Opinion on Drug Delivery 16(6): 649-656.
- Völler S., Flint R.B., Andriessen P., Allegaert K., Zimmermann L.J.I., Liem K.D., Koch B.C.P., Simons S.H.P. & Knibbe C.A.J. (2019), Rapidly maturing fentanyl clearance in preterm neonates, Archives of Disease in Childhood. Fetal and Neonatal Edition 104(6): F598-F603.
- Voller S., Flint R.B., Beggah F., Reiss I., Andriessen P., Zimmermann L.J.I., Anker J.N. van den, Liem K.D., Koch B.C.P., Wildt S. de, Knibbe C.A.J. & Simons S.H.P. (2019), Recently Registered Midazolam Doses for Preterm Neonates Do Not Lead to Equal Exposure: A Population Pharmacokinetic Model, The Journal of Clinical Pharmacology 59(10): 1300-1308.
- Smit C., Wasmann R.E., Wiezer M.J., Dongen H.P.A. van, Mouton J.W., Bruggemann R.J.M. & Knibbe C.A.J. (2019), Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study, Pharmaceutical Research 36: 112.
- Krekels E.H.J. & Knibbe C.A.J. (2019), Pharmacokinetics and pharmacodynamics of drugs in obese pediatric patients: how to map uncharted clinical territories. In: Kiess W., Schwab M. & Anker J. van den (Eds.), Pediatric Pharmacotherapy . Handbook of Experimental Pharmacology no. 261. Cham: Springer. 231-255.
- Goulooze S.C., Völler S., Valitalo P.A.J., Calvier E.A.M., Aarons L., Krekels E.H.J. & Knibbe C.A.J. (2019), The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models, Clinical Pharmacokinetics 58(1): 131-138.
- Goulooze S.C., Krekels E.H.J., Hankemeier T. & Knibbe C.A.J. (2019), Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools, AAPS Journal 21: 11.
- Hoogd S. de, Valkenburg A.J., Dongen E.P.A. van, Daeter E.J., Rosmalen J. van, Dahan A., Tibboel D. & Knibbe C.A.J. (2019), Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial, European Journal of Anaesthesiology 36(1): 32-39.
- Wasmann R.E., Smit C., Heine R. ter, Koele S.E., Dongen E.P.H. van, Wiezer R.M.J., Burger D.M., Knibbe C.A.J. & Brüggemann R.J.M. (2019), Pharmacokinetics and probability of target attainment for micafungin in normal-weight and morbidly obese adults, Journal of Antimicrobial Chemotherapy 74(4): 978-985.
- Brussee J.M., Vet N.J., Krekels E.H.J., Valkenburg A.J., Jacqz-Aigrain E., Gerven J.M.A. van, Swart E.L., Anker J.N. van den, Tibboel D., Hoog M. de, Wildt S.N. de & Knibbe C.A.J. (2018), Predicting CYP3A-mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure, British Journal of Clinical Pharmacology 84(2): 358-368.
- Goulooze S.C., Välitalo P.A.J., Knibbe C.A.J. & Krekels E.H.J. (2018), Kernel-Based Visual Hazard Comparison (kbVHC): a Simulation-Free Diagnostic for Parametric Repeated Time-to-Event Models, AAPS Journal 20(1): 5.
- Kleiber N., Calvier E., Mooij M.G., Krekels E.H., Vaes W.H., Windhorst A.D., Hendrikse H., Tibboel D., Knibbe C.A. & Wildt S.N. de (2018), A 14C oral bioavailability microtracer study shows that oral acetaminophen exposure is low and erratic in critically ill children: a case for I.V. acetaminophen, Clinical Pharmacology & Therapeutics 103: S41-S41.
- Wasmann R.E., Muilwijk E.W., Burger D.M., Verweij P.E., Knibbe C.A.J. & Bruggemann R.J. (2018), Clinical Pharmacokinetics and Pharmacodynamics of Micafungin, Clinical Pharmacokinetics 57(3): 267-286.
- Smit C., Hoogd S. de, Bruggemann R.J.M. & Knibbe C.A.J. (2018), Obesity and drug pharmacology: a review of the influence of obesity on pharmacokinetic and pharmacodynamic parameters, Expert Opinion on Drug Metabolism & Toxicology 14(3): 275-285.
- Calvier E.A.M., Krekels E.H.J., Yu H., Välitalo P.A.J., Johnson T.N., Rostami-Hodjegan A., Tibboel D., Graaf P.H. van der, Danhof M. & Knibbe C.A.J. (2018), Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments, CPT: Pharmacometrics and Systems Pharmacology 7(3): 175-185.
- Hoogd S. de, Ahlers S.J.G.M., Dongen E.PA. van, Garde E.M.W. van de, Daeter E.J., Dahan A., Tibboel D. & Knibbe C.A.J. (2018), Randomized Controlled Trial on the Influence of Intraoperative Remifentanil versus Fentanyl on Acute and Chronic Pain after Cardiac Surgery, Pain Practice 18(4): 443-451.
- Wasmann R.E., Heine R. ter, Dongen E.P. van, Burger D.M., Lempers V.J., Knibbe C.A. & Brüggemann R.J. (2018), Pharmacokinetics of Anidulafungin in Obese and Normal-Weight Adults, Antimicrobial Agents and Chemotherapy 62(7): e00063-18.
- Smit C. & Knibbe C.A.J. (2018), Geneesmiddelen doseren bij (morbide) obesitas: veranderingen in farmacokinetiek en farmacodynamiek, PiL Nascholingstijdschrift over Farmacotherapie (1): .
- Rongen A. van, Anker J.N. van den & Knibbe C.A.J. (2018), Author's Reply to Reith: "Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults", Clinical Pharmacokinetics 57(10): 1357-1358.
- Rongen A. van, Valitalo P.A.J. & Knibbe C.A.J. (2018), Author's Reply to Reith: "Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen", Clinical Pharmacokinetics 57(7): 897-899.
- Calvier E.A.M., Thu T.N., Johnson T.N., Rostami-Hodjegan A., Tibboel D., Krekels E.H.J. & Knibbe C.A.J. (2018), Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory, Pharmaceutical Research 35(11): 209.
- Brussee J.M., Yu H., Krekels E.H.J., Palic S., Brill M.J.E., Barrett J.S., Rostami-Hodjegan A., Wildt S.N. de & Knibbe C.A.J. (2018), Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach, Pharmaceutical Research 35: 182.
- Brussee J.M., Yu H., Krekels E.H.J., Roos B. de, Brill M.J.E., Anker J.N. van den, Rostami-Hodjegan A., Wildt S.N. de & Knibbe C.A.J. (2018), First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates, CPT: Pharmacometrics and Systems Pharmacology 7(6): 374-383.
- Rongen A. van, Aa M.P van der, Matic M., Schaik R.H.N. van, Deneer V.H.M., Vorst M.M. van der & Knibbe C.A.J. (2018), Increased Metformin Clearance in Overweight and Obese Adolescents: A Pharmacokinetic Substudy of a Randomized Controlled Trial, Pediatric Drugs 20(4): 365-374.
- Lentferink Y.E., Aa M.P. van der, Mill E.G.A.H. van, Knibbe C.A.J. & Vorst M.M.J. van der (2018), Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study, Nutrition and Diabetes 8: 47.
- Lentferink Y.E., Garde E.M.W. van de, Knibbe C.A.J. & Vorst M.M.J. (2018), Psychostimulants: Influence on Body Mass Index and Height in a Pediatric Population with Attention-Deficit/Hyperactivity Disorder?, Journal of Child and Adolescent Psychopharmacology 28(8): 530-536.
- Flint R.B., Heine R. ter, Spaans E., Burger D.M., Klerk J.C.A. de, Allegaert K., Knibbe C.A.J. & Simons S.H.P. (2018), Simulation-based suggestions to improve ibuprofen dosing for patent ductus arteriosus in preterm newborns, European Journal of Clinical Pharmacology 74(12): 1585-1591.
- Lentferink Y.E., Knibbe C.A.J. & Vorst M.M.J. van der (2018), Efficacy of Metformin Treatment with Respect to Weight Reduction in Children and Adults with Obesity: A Systematic Review, Drugs 78(18): 1887-1901.
- Lentferink Y.E., Teeseling L. van, Knibbe C.A.J. & Vorst M.M.J. van der (2018), Skin autofluorescence in children with and without obesity, Journal of Pediatric Endocrinology and Metabolism 32(1): 41-47.
- Zeilmaker G.A., Pokorna P., Mian P., Wildschut E.D., Knibbe C.A.J., Krekels E.H.J., Allegaert K. & Tibboel D. (2018), Pharmacokinetic considerations for pediatric patients receiving analgesia in the intensive care unit; targeting postoperative, ECMO and hypothermia patients, Expert Opinion on Drug Metabolism & Toxicology 14(4): 417-428.
- Standing J.F., Anderson B.J., Hennig S., Holford N.H., Johnston T.N., Knibbe C.A.J., Lonsdale D.O. & Rostami-Hodjegan A. (2018), Comment on "Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials", Clinical Pharmacokinetics 57(11): 1471-1472.
- Kantae V., Krekels E.H.J., Esdonk M.J. van, Lindenburg P.W., Harms A.C., Knibbe C.A.J., Graaf P.H. van der & Hankemeier T. (2017), Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy, Metabolomics 13(1): 9.
- Calvier E.A.M., Krekels E.H.J., Välitalo P.A.J., Rostami-Hodjegan A., Tibboel D., Danhof M. & Knibbe C.A.J. (2017), Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?, Clinical Pharmacokinetics 56(3): 273-285.
- Kantae V., Krekels E.H.J., Esdonk M.J. van, Lindenburg P.W., Harms A.C., Knibbe C.A.J., Graaf P.H. van der & Hankemeier T. (2017), Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy: an addition to the topical collection "Recent Advances in Pharmacometabolomics: Enabling Tools for Precision Medicine", Metabolomics 13(5): 58.
- Völler S., Flint R.B., Stolk L.M., Degraeuwe P.L.J., Simons S.H.P., Pokorna P., Burger D.M., Groot R. de, Tibboel D. & Knibbe C.A.J. (2017), Model-based clinical dose optimization for phenobarbital in neonates: an illustration of the importance of data sharing and external validation, European Journal of Pharmaceutical Sciences 109: S90-S97.
- Flint R., Weteringen W.V., Völler S., Poppe J.A., Koch B.C., Groot R., Tibboel D., Knibbe C.A., Reiss I.K. & Simons S.H. (2017), Big data analyses for continuous evaluation of pharmacotherapy: A proof of principle with doxapram in preterm infants, Current Pharmaceutical Design 23(38): 5919-5927.
- Kohler I., Hankemeier T., Graaf P.H. van der, Knibbe C.A.J. & Hasselt J.G.C. van (2017), Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine, European Journal of Pharmaceutical Sciences 109: S15-S21.
- Goulooze S.C., Krekels E.H.J., Dijk M. van, Tibboel D., Graaf P.H. van der, Hankemeier T., Knibbe C.A.J. & Hasselt J.G.C. van (2017), Towards personalized treatment of pain using a quantitative systems pharmacology approach, European Journal of Pharmaceutical Sciences 109: S32-S38.
- Mian P., Knibbe C.A.J., Calvier E.A.M., Tibboel D. & Allegaert K. (2017), Intravenous Paracetamol Dosing Guidelines for Pain Management in (pre)term Neonates Using the Paediatric Study Decision Tree, Current Pharmaceutical Design 23(38): 5839-5849.
- Flint R.B., Roofthooft D.W., Rongen A. van, Lingen R.A., Anker J.N. van den, Dijk M. van, Allegaert K., Tibboel D., Knibbe C.A.J. & Simons S.H.P. (2017), Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants, Pediatric Research 82(4): 678-684.
- Rongen A. van, Brill M.J.E., Vaughns J.D., Välitalo P.A.J., Dongen E.P.A. van, Ramshorst B. van, Barrett J.S., Anker J.N. van den & Knibbe C.A.J. (2017), Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults, Clinical Pharmacokinetics 57(5): 601-611.
- Krekels E.H.J., Hasselt J.G.C. van, Anker J.N. van den, Allegaert K., Tibboel D. & Knibbe C.A.J. (2017), Evidence-based drug treatment for special patient populations through model-based approaches, European Journal of Pharmaceutical Sciences 109(Supplement): S22-S26.
- Valitalo P.A.J., Krekels E.H.J., Dijk M. van, Simons S.H.P., Tibboel D. & Knibbe C.A.J. (2017), Morphine Pharmacodynamics in Mechanically Ventilated Preterm Neonates Undergoing Endotracheal Suctioning, CPT: Pharmacometrics and Systems Pharmacology 6(4): 239-248.
- Hoogd S. de, Välitalo P.A.J., Dahan .A., Kralingen S. van, Coughtrie M.M.W., Dongen E.P.A. van, Ramshorst B. van & Knibbe C.A.J. (2017), Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide, Clinical Pharmacokinetics 56(12): 1577-1587.
- Lentferink Y.E., Elst M.A.J., Knibbe C.A.J. & Vorst M.M.J. van der (2017), Predictors of Insulin Resistance in Children versus Adolescents with Obesity, Journal of Obesity 2017: 3793868.
- Xiong Y., Fukuda T., Knibbe C.A.J. & Vinks A.A. (2017), Drug Dosing in Obese Children Challenges and Evidence-Based Strategies, Pediatric Clinics of North America 64(6): 1417-1438.
- Hoogd S. de, Ahlers S.J.G.M., Dongen E.P.A. van, Garde E.M.W. van de, Hamilton-Ter Brake T.A.T., Dahan A., Tibboel D. & Knibbe C.A.J. (2016), Is intraoperative Remifentanil associated with acute or chronic postoperative pain after prolonged surgery? An update of the literature, Clinical Journal of Pain 32(8): 726-735.
- Mooij M.G., Nies A.T., Knibbe C.A.J., Schaeffeler E., Tibboel D., Schwab M. & Wildt S.N. de (2016), Development of human membrane transporters: drug disposition and pharmacogenetics, Clinical Pharmacokinetics 55(5): 507-524.
- Valkenburg A.J, Calvier E.A.M., Dijk M. van, Krekels E.H.J., O'Hare B.P., Casey W.F., Mathôt R.A., Knibbe C.A.J, Tibboel D. & Breatnach C.V. (2016), Pharmacodynamics and Pharmacokinetics of morphine after cardiac surgery in children with and without Down Syndrome, Pediatric Critical Care Medicine 17(10): 930-938.
- Lempers V.J., Rongen A. van, Dongen E.P. van, Ramshorst B. van, Burger D.M., Aarnoutse R.E., Knibbe C.A.J. & Bruggemann R.J. (2016), Does weight impact anidulafungin pharmacokinetics?, Clinical Pharmacokinetics 55(10): 1289-1294.
- Rongen A. van, Välitalo P.A.J., Peeters M.Y., Boerma D., Huisman F.W., Ramshorst B. van, Dongen E.P. van, Anker J.N. van den & Knibbe C.A.J. (2016), Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen, Clinical Pharmacokinetics 55(7): 833-847.
- Vet N.J., Wildt S.N. de, Verlaat C.W.M., Knibbe C.A.J., Mooij M.G., Woensel J.B.M. van, Rosmalen J. van, Tibboel D. & Hoog M. de (2016), A randomized controlled trial of daily sedation interruption in critically ill children, Intensive Care Medicine 42(2): 233-244.
- Brussee J.M., Calvier E.A., Krekels E.H.J., Välitalo P.A.J., Tibboel D., Allegaert K. & Knibbe C.A. (2016), Children in clinical trials: towards evidence-based pediatric pharmacotherapy using pharmacokinetic-pharmacodynamic modeling, Expert review of clinical pharmacology 9(9): 1235-1244.
- Janssen E.J.H., Välitalo P.A.J., Allegaert K., Cock R.F.W. de, Simons S.H., Sherwin C.M., Mouton J.W., Anker J.N. van den & Knibbe C.A.J. (2016), Towards Rational Dosing Algorithms for Vancomycin in Neonates and Infants Based on Population Pharmacokinetic Modeling, Antimicrobial Agents and Chemotherapy 60(2): 1013-1021.
- Välitalo P.A., Dijk M. van, Krekels E.H.J., Gibbins S., Simons S.H., Tibboel D. & Knibbe C.A.J. (2016), Pain and distress caused by endotracheal suctioning in neonates is better quantified by behavioural than physiological items: a comparison based on item response theory modelling, Pain 157(8): 1611-1617.
- Vet N.J., Brussee J.M., Hoog M. de, Mooij M.G., Verlaat C.W., Jerchel I.S., Schaik R.H. van, Koch B.C., Tibboel D., Knibbe C.A. & Wildt S.N. de (2016), Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children, American Journal of Respiratory and Critical Care Medicine 194(1): 58-66.
- Krekels E.H.J., Tibboel D. & Knibbe C.A.J. (2015), Pediatric pharmacology: current efforts and future goals to improve clinical practice, Expert Opinion on Drug Metabolism & Toxicology 11(11): 1679-1682.
- Krekels E.H.J., Ham S. van, Allegaert K., Hoon J. de, Tibboel D., Danhof M. & Knibbe C.A.J. (2015), Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants, European Journal of Clinical Pharmacology 71(9): 1075-82.
- Krekels E.H.J., Knibbe C.A.J., Pokorna P. & Tibboel D. (2015), How to Translate Pharmacokinetic Data into Dosing Recommendations. In: Mimouni F.B. & Anker J.N. van den (Eds.), Neonatal Pharmacology and Nutrition Update no. 18. Basel: Karger. 13-27.
- Ahlers S.J., Välitalo P.A., Peeters M.Y., Gulik L.V., Dongen E.P. van, Dahan A., Tibboel D. & Knibbe C.A.J. (2015), Morphine Glucuronidation and Elimination in Intensive Care Patients: A Comparison with Healthy Volunteers, Anesthesia and Analgesia 121(5): 1261-1273.
- Valitalo P.A., Anker J.N. van den, Allegaert K., Cock R.F.W. de, Hoog M. de, Simons S.H., Mouton J.W. & Knibbe C.A.J. (2015), Novel model-based dosing guidelines for gentamicin and tobramycin in preterm and term neonates, Journal of Antimicrobial Chemotherapy 70(7): 2074-2077.
- Diepstraten J., Janssen E.J., Hackeng C.M., Dongen E.P. van, Wiezer R.J., Ramshorst B. van & Knibbe C.A.J. (2015), Population pharmacodynamic model for low molecular weight heparin nadroparin in morbidly obese and non-obese patients using anti-Xa levels as endpoint, European Journal of Clinical Pharmacology 71(1): 25-34.
- Knibbe C.A., Brill M.J., Van Rongen A., Diepstraten J., Van der Graaf P.H. & Danhof M. (2015), Drug disposition in obesity: toward evidence-based dosing, Annual Review of Pharmacology and Toxicology 55: 149-67.
- De Cock R.F., Allegaert K., Sherwin C.M., Nielsen E.I., De Hoog M., Van den Anker J.N., Danhof M. & Knibbe C.A. (2014), A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates, Pharmacological Research 31(3): 754-67.
- Wang C., Allegaert K., Peeters M.Y., Tibboel D., Danhof M. & Knibbe C.A. (2014), The allometric exponent for scaling clearance varies with age: a study on seven propofol datasets ranging from preterm neonates to adults, British Journal of Clinical Pharmacology 77(1): 149-59.
- Krekels E.H.J., Tibboel D., Wildt S.N. de, Ceelie I., Dahan A., Dijk M. van, Danhof M. & Knibbe C.A.J. (2014), Evidence-based morphine dosing for postoperative neonates and infants, Clinical Pharmacokinetics 53(6): 553-563.
- Brill M.J., Rongen A. van, Houwink A.P., Burggraaf J., Ramshorst B. van, Wiezer R.J., Dongen E.P. van & Knibbe C.A. (2014), Midazolam pharmacokinetics in morbidly obese patients following semi-simultaneous oral and intravenous administration: a comparison with healthy volunteers, Clinical Pharmacokinetics 53(10): 931-941.
- Brill M.J., Houwink A.P., Schmidt S., Dongen E.P. van, Hazebroek E.J., Ramshorst B. van, Deneer V.H., Mouton J.W. & Knibbe C.A.J. (2014), Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis, Journal of Antimicrobial Chemotherapy 69(3): 715-723.
- Hoogd S. de, Ahlers S.J., Dongen E.P. van, Tibboel D., Dahan A. & Knibbe C.A.J. (2014), Remifentanil versus fentanyl during cardiac surgery on the incidence of chronic thoracic pain (REFLECT): study protocol for a randomized controlled trial, Trials 15: 466.
- Wang C., Allegaert K., Tibboel D., Danhof M., Marel C.D. van der, Mathot R.A. & Knibbe C.A. (2013), Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults, The Journal of Clinical Pharmacology : .
- De Cock R.F., Allegaert K., Sherwin C.M., Nielsen E.I., Hoog M. de, Anker J.N. van den, Danhof M. & Knibbe C.A. (2013), A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates, Pharmaceutical Research 31(3): 754-67.
- Wang C., Allegaert K., Peeters M.Y., Tibboel D., Danhof M. & Knibbe C.A. (2013), The allometric exponent for scaling clearance varies with age: a study on seven propofol datasets ranging from preterm neonates to adults, British Journal of Clinical Pharmacology 77(1): 149-59.
- Cock R.F. de, Allegaert K., Vanhaesebrouck S., Hoon J. de, Verbesselt R., Danhof M. & Knibbe C.A. (2013), Low but Inducible Contribution of Renal Elimination to Clearance of Propylene Glycol in Preterm and Term Neonates, Therapeutic Drug Monitoring : .
- Knibbe C.A., Tibboel D., Wildt S.N. de, Hoog M. de, Tjoeng M.M. & Danhof M. (2013), [Individualized dosing guidelines for children], Nederlands Tijdschrift voor Geneeskunde 157(16): A4214.
- Wang C., Sadhavisvam S., Krekels E.H.J., Dahan A., Tibboel D., Danhof M., Vinks A.A. & Knibbe C.A.J. (2013), Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model, Clinical Drug Investigation 33(7): 523-534.
- Krekels E.H.J., Johnson T.N., Hoedt S.M. den, Rostami-Hodjegan A., Danhof M., Tibboel D. & Knibbe C.A.J. (2012), From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II-Sensitivity to Physiological and Physicochemical Properties, CPT: Pharmacometrics and Systems Pharmacology 2012(1): e10.
- Krekels E.H.J., Neely M., Panoilia E., Tibboel D., Capparelli E., Danhof M., Mirochnick M. & Knibbe C.A.J. (2012), From pediatric covariate model to semiphysiological function for maturation: part I-extrapolation of a covariate model from morphine to Zidovudine, CPT: Pharmacometrics and Systems Pharmacology 2012(1): e9.
- Wang C., Peeters M.Y., Allegaert K., Blussé van Oud-Alblas H.J., Krekels E.H.J., Tibboel D., Danhof M. & Knibbe C.A.J. (2012), A bodyweight-dependent allometric exponent for scaling clearance across the human life-span, 29(6): 1570-1581.
- Krekels E.H.J., Danhof M., Tibboel D. & Knibbe C.A.J. (2012), Ontogeny of hepatic glucuronidation; methods and results, Current Drug Metabolism 13(6): 728-743.
- Krekels E.H.J., Tibboel D. & Knibbe C.A.J. (2012), Prediction of morphine clearance in the paediatric population : how accurate are the available pharmacokinetic models?, Clinical Pharmacokinetics 51(11): 695-709.
- Knibbe C.A., Krekels E.H. & Danhof M. (2011), Advances in paediatric pharmacokinetics, Expert Opinion on Drug Metabolism & Toxicology 7(1): 1-8.
- Bartelink I.H., Belitser S.V., Knibbe C.A.J., Danhof M., De Pagter A.J., Egberts A.C.G. & Boelens J.J. (2011), Cd3+Cd4+and Cd3+Cd8+-Lymphocytes as Biomarkers Predicting the Long Term Outcome of Pediatric Haematopoietic Stem Cell Transplantation Recipients, Biology of Blood and Marrow Transplantation 17(2): .
- Bartelink I.H., Boelens J.J., Bredius R.G.M., Egberts A.C.G., Biering M., Shaw P., Nath C.E., Hempel G., Zwaveling J., Danhof M. & Knibbe C.A.J. (2011), Optimizing the Busulfan Dosing Regimen to Get a More Predictable Exposure: A Data Driven Analysis, Biology of Blood and Marrow Transplantation 17(2): .
- Cock R.F.W. de, Piana C., Krekels E.H.J., Danhof M., Allegaert K. & Knibbe C.A.J. (2011), The role of population PK-PD modelling in paediatric clinical research, European Journal of Clinical Pharmacology 67(Suppl 1): 5-16.
- Krekels E.H.J., Hasselt J.G.C. van, Tibboel D., Danhof M. & Knibbe C.A.J. (2011), Systematic evaluation of the descriptive and predictive performance of paediatric morphine population models, Pharmaceutical Research 28(4): 797-811.
- Bartelink I.H., Boelens J.J., Bredius R.G.M., Egberts A.C.G., Bierings M., Shaw P., Hempel G., Zwaveling J., Danhof M. & Knibbe C.A.J. (2011), Modeling of the Age-Related Pharmacokinetics in Children. A Data-Driven Analysis of Busulfan Prior to Haemopoietic Stem Cell Transplantation, British Journal of Clinical Pharmacology 72(5): .
- Bartelink I.H., Belitser S.V., Knibbe C.A.J., Danhof M., De Pagter P.J., Egberts A.C.G. & Boelens J.J. (2011), Cd3+Cd4+-Lymphocytes as Biomarker Predicting the Outcome of Pediatric Haematopoietic Stem Cell Transplantation Recipients, British Journal of Clinical Pharmacology 72(5): .
- Krekels E.H., DeJongh J., Van Lingen R.A., Van der Marel C.D., Choonara I., Lynn A.M., Danhof M., Tibboel D. & Knibbe C.A. (2011), Predictive performance of a recently developed population pharmacokinetic model for morphine and its metabolites in new datasets of (preterm) neonates, infants and children, Clinical Pharmacokinetics 50(1): 51-63.
- Krekels E.H.J., Van Ham S., Allegaert K., De Hoon J., Tibboel D., Danhof M. & Knibbe C.A.J. (2011), Paracetamol Pharmacokinetics in Term and Preterm Neonates, British Journal of Clinical Pharmacology 72(5): .
- Bartelink I.H., Jol-Van der Zijde E.M., Boelens J.J., Bredius R.G.M., Egberts A.C.G., Danhof M., Van Tol MJD & Knibbe C.A.J. (2011), Optimization of Anti-Thymocyte Globulin Exposure in Paedi-Atric Bone Marrow Transplantation in Order to Design an Individualized Dosing Regimen, Biology of Blood and Marrow Transplantation 17(2): .
- De Cock R.F.W., Allegaert K., De Hoog M., Sherwin C.M.T., Danhof M. & Knibbe C.A.J. (2011), Predicting Glomerular Filtration Rate Using Clearance of Amikacin in Neonates - Model Evaluation, British Journal of Clinical Pharmacology 72(5): .
- Wang C., Peeters M.Y.M., Allegaert K., Tibboel D., Danhof M. & Knibbe C.A.J. (2011), Scaling Clearance of Propofol from Preterm Neonates to Adults, British Journal of Clinical Pharmacology 72(5): .
- Knibbe C.A.J., Krekels E.H.J., Anker J.N. van den, DeJongh J., Santen G.W., Dijk M. van, Simons S.H., Lingen R.A. van, Jacqz-Aigrain E.M., Danhof M. & Tibboel D. (2009), Morphine glucuronidation in preterm neonates, infants and children younger than 3 years, Clinical Pharmacokinetics 48(6): 371-385.
- Peeters M.Y., Bras L.J., DeJongh J., Wesselink R.M., Aarts L.P., Danhof M. & Knibbe C.A.J. (2008), Disease Severity Is a Major Determinant for the Pharmacodynamics of Propofol in Critically Ill Patients, Clinical Pharmacology & Therapeutics 83(3): 443-451.
- Ahlers S.J., Gulik L. van, Veen A.M. van der, Dongen H.P., Bruins P., Belitser S.V., Boer A.G. de, Tibboel D. & Knibbe C.A.J. (2008), Comparison of different pain scoring systems in critically ill patients in a general ICU, Critical Care Medicine 12(1): R15.
- Peeters M.Y., Aarts L.P., Boom F.A., Bras L.J., Tibboel D., Danhof M. & Knibbe C.A.J. (2008), Pilot study on the influence of liver blood flow and cardiac output on the clearance of propofol in critically ill patients, European Journal of Clinical Pharmacology 64(3): 329-334.
- Knibbe C.A.J. & Tjoeng M.M. (2008), Clinical pharmacist on intensive care unit saves lives and reduces costs, Critical Care Medicine 36(12): 3269-3270.
- Krekels E.H., Anker J.N. van den, Baiardi P., Cella M., Cheng K.Y., Gibb D.M., Green H., Iolascon A., Jacqz-Aigrain E.M., Knibbe C.A.J., Santen G.W.E., Schaik R.H. van, Tibboel D. & Della Pasqua O.E. (2007), Pharmacogenetics and paediatric drug development: issues and consequences to labelling and dosing recommendations, Expert Opinion on Pharmacotherapy 8(12): 1787-1799.
- Krekels E.H.J., Anker J.N. van der, Baiardi P., Cella M., Cheng K.Y., Gibb D.M., Green H., Iolascon A., Jacqz-Aigrain E.M., Knibbe C.A.J., Santen G.W., Schaik R.H. van, Tibboel D. & Della Pasqua O.E. (2007), Pharmacogenetics and paediatric drug development: issues and consequences to labelling and dosing recommendations, Expert Opinion on Pharmacotherapy 8(12): 1787-1799.
- Peeters M.Y., Prins S.A., Knibbe C.A.J., DeJongh J., Schaik R.H. van, Dijk M. van, Heiden I. van der, Tibboel D. & Danhof M. (2006), Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery, Anesthesiology 104(3): 466-474.
- Peeters M.Y., Prins S.A., Knibbe C.A.J., DeJongh J., Mathot R.A.A., Warris C., Schaik R.H. van, Tibboel D. & Danhof M. (2006), Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery, Anesthesiology 105(6): 1135-1146.
- Knibbe C.A.J., Zuideveld K.P., Aarts L.P., Kuks P.F.M. & Danhof M. (2005), Allometric relationships between the pharmacokinetics of propofol in rats, children and adults, British Journal of Clinical Pharmacology 59(6): 705-711.
- Prins S.A., Peeters M.Y., Houmes R.J., Dijk M. van, Knibbe C.A.J., Danhof M. & Tibboel D. (2005), Propofol 6% as sedative in children under 2 years of age following major craniofacial surgery, British Journal of Anaesthesia 94(5): 630-635.
- Knibbe C.A.J., Naber H., Aarts L.P.H.J., Kuks P.F.M. & Danhof M. (2004), Long-term sedation with propofol 60 mg/ml versus Propofil 10 mg/ml in critically ill, mechanically ventilated patients, Acta Anaesthesiologica Scandinavica 48: 302-307.
- Cremers S.C.L.M. (19 February 2004), Clinical pharmacokinetics and pharmacodynamics of bisphosphonates in metabolic bone diseases (Dissertatie, Leiden University). Leiden: UFB, Universiteit Leiden. Supervisor(s): Papapoulos S.E. & Vermeij P.
- Knibbe C.A.J., Zuideveld K.P., Jongh J. de, Kuks P.F.M., Aarts L.L.P. & Danhof M. (2002), Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: A comparison between propofol 6% and propofol 1%, Clinical Pharmacology & Therapeutics 72: 670-684.
- Knibbe C.A.J., Melenhorst-de Jong G., Mestrom M., Rademaker C.M.A., Reijnvaan A.F.A., Zuideveld K.P., Kuks P.F.M., Vught H. van & Danhof M. (2002), Pharmacokinetic and effects of propofol 6% for short-term sedation in paediatric patients following cardiac Surgery, Br. J. Clin. Pharmacol. 54: 415-422.
- Ziekenhuisapotheker-Klinisch Farmacoloog (Staflid)
- guestappointment
- Lid programma commissie(s)
- Geven van lezingen op nascholingsactiviteiten