Catherijne Knibbe (Prof. Dr.) is Professor of Individualized Drug Treatment.

More information about Catherijne Knibbe

Profile

Catherijne Knibbe is clinical pharmacologist-hospital pharmacist in the St. Antonius Hospital in Nieuwegein/Utrecht and professor of Individualized Drug Treatment at the LACDR, Faculty of Science at Leiden University. At the Erasmus MC/Sophia Childrens Hospital, she holds a guest appointment for different collaborative pediatric clinical pharmacology projects.

Research and Clinical Activities

Knibbe leads the Quantitative Clinical Pharmacology group which focuses on the development and application of advanced computational techniques combining the statistical power of the Population approach with Physiologically-Based approaches, to predict the efficacy and safety of drugs and optimize dosing in special patient populations like such as (prematurely born) neonates or children, individuals with obesity or critically ill patients. 

She has 25+ years of experience with (design of) pediatric clinical trials and adult clinical pharmacology studies both from investigator-initiated and drug development point of view, through her own clinical studies in the hospital, as co-investor of many pediatric clinical studies in the Sophia Childrens Hospital Rotterdam, and as vice-chair/member of the national IRB (CCMO) from 2011-2023. 

In the St. Antonius hospital, Dr. Knibbe is consultant for the department of Intensive Care and Anesthesiology, is supervisor of the Clinical Pharmacology training program, is co-supervisor of the Hospital Pharmacy training program, and is member of the Daily Board of the Department of Clinical Pharmacy of the St. Antonius hospital.

She has supervised 26 PhD students, is currently co-supervising 9 PhD students and Post Docs, and is co-author of over 280 international peer-reviewed publications and contributions to books. She is a frequently invited speaker on national and international conferences.

Awards

Dr. Knibbe became a Fellow (FCP) of the American College of Clinical Pharmacology (ACCP) in 2019. For her research, she is supported by different grants, among which different ZonMw grants for dosing individualization in neonates, children and individuals with obesity, the prestigious Vidi grant in 2013 for her research project ‘From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling’ and a Veni grant in 2006. In 2009, she was awarded the ‘Huizenga penning’ by the Dutch Society of Hospital Pharmacy, which is an award presented to young Dutch hospital-pharmacists for scientific work of outstanding quality. In 2002, she received the Best PhD Thesis Award 2002 by the Dutch Society of Clinical Pharmacology and Biopharmacy. Many of her (former) PhD students have received awards for their work.

Other activities

Dr. Knibbe is an active member of the American College of Clinical Pharmacology (ACCP) where she serves in the Board of Regents, as co-chair of the Annual Meeting program committee 2024, and many other capacities. She is a member of Scientific Council of Kika, member of the national expert group on dosing guidelines for obese and bariatric surgery patients of the KNMP, has been member of the Central Committee of Research Involving Human Subjects (the 'CCMO') in The Hague from 2011-2023, member of the certification committee of the Dutch Society of Clinical Pharmacology & Biopharmacy from 2004-2023, has been chair of the Concilium Hospital Pharmacy of the Dutch Society of Hospital Pharmacy and member of the national Committee of State ‘Doek’ involving medical-ethical aspects of (non-therapeutic) research in children (2007-2009).

Publications