Are you looking for a research project?

We have projects available for motivated 6–9-month internship students with an interest in antiviral pharmacology, computational modeling, clinical studies, or experimental work to describe drug exposure-response (PK/PD) relationships. 

Below you find a list of available research topics: 

Antiviral dose optimization, pharmacokinetic/pharmacodynamic relationships

Antivirals such as ganciclovir and cidofovir can cause harmful side effects in clinical care. Currently many unknowns remain in how to optimize therapy of different antivirals. Here clinical data can be utilized to further investigate the PK/PD relationships. In addition, laboratory experiments and computational modelling can be utilized to describe PK/PD relationships and to translate the findings to patient care. 

Computational modelling to investigate dynamics of viral infections

Drug efficacy is strongly connected to viral expansion and dynamics. Existing data can be utilized to develop viral dynamic models to investigate spread and dynamics of viral infections and relating this to antiviral drug exposure. These models can help develop dosing strategies for existing and emerging viruses. 

Therapeutic drug monitoring of antivirals

The utility of ganciclovir therapeutic drug monitoring has been previously shown for patients with extremes of kidney function. The data from solid organ and stem cell transplant recipients can be used to develop mathematical models to help guide dose optimization, develop new dosing strategies and develop models for model-informed precision dosing in clinical care.

If you have any questions, please contact Anne-Grete Märtson.