The aim of my antiviral translational pharmacology research group is to optimise antiviral drug dosing and therapy using computational and laboratory methods. Currently, there are many unknowns in optimising therapy for viral infections. I focus on the drug exposure-response relationships (PK/PD) to investigate what are the optimal targets for efficient therapy with least toxicity while preventing development of drug resistance. We conduct clinical studies, laboratory experiments and use computational methods to find best treatment regimens and translate results back to the clinical setting. We work closely with pharmacometricians, virologists, microbiologists and clinicians.

More information about Anne-Grete Märtson

Anne-Grete Märtson is an assistant professor at the Division of Systems Pharmacology and Pharmacy, which is part of the Leiden Academic Centre for Drug Research (LACDR). My research group focuses on translational antiviral pharmacology. We conduct clinical studies, laboratory experiments and use computational methods to find best treatment regimens and translate results back to the clinical setting. 

I obtained my PhD degree (2021) from University of Groningen, the Netherlands. Before my PhD I worked as a clinical pharmacist at Tartu University Hospital, Estonia, where I was involved in patient care. My PhD work focused on optimising anti-infective therapy for immunocomromised patients through conducting clinical studies of therapeutic drug monitoring and modelling the pharmacokinetics and pharmacodynamics of different anti-infectives (e.g., posaconazole, fluconazole, voriconazole, ganciclovir, caspofungin). From 2021-2023 I worked as a postdoctoral researcher at University of Liverpool, United Kingdom, where I worked with laboratory infection models to investigate the pharmacokinetics and pharmacokinetics of anti-infectives. My focus was optimising therapy of cytomegalovirus through setting up different in vitro methodologies to investigate the drug and virus relationship. 

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