Medical Biochemistry
Projects
Research projects
At Medical Biochemistry in collaboration with Bio-Organic Synthesis, LIC
- Analytical chemistry and biochemistry of glycosphingolipids ( M. Mirzaian)
- Impact of LIMP-2 deficiency on lysosomal glucocerebrosidase (P. Gaspar)
- Lysosomal proteases: a target for Gaucher disease treatment? ( S. Oussoren)
- Endogenous and recombinant human alpha-galactosidase produced in plants ( K. Kytidou)
- Glycosphingolipids and Metabolic Syndrome ( M. van Eijk)
- Zebra fish models of LSDs: screening for therapeutic agents ( W. Kallemeijn & L. Lelieveld)
- Pluripotent stem cells and investigations on lysosomal storage disease ( R. Boot)
- Sphingolipid-based chemical biology probes ( P. Haberkant)
- Intracellular sorting mechanisms for lysosomal proteins ( E. van Meel)
- Novel metabolites formed by transglycosylation
- Activity-based probes for lysosomal glycosidases in biomedical research ( C-L. Kuo)
At Bio-Organic Synthesis (Prof. H.S. Overkleeft)
- Synthesis of labeled complex glycosphingolipids ( P. Wisse)
- Design and synthesis of glycosidase activity based probes ( J. Jiang)
- Design and synthesis of glycosyltransferase inhibitors ( T. Beenakker)
- Iminosugars as glycosidase inhibitors ( B. Liu)
At Macromolecular Biochemistry (Prof. M. Ubbink)
- NMR investigations on glycosidases ( F. Ben Bdira)
Still ongoing at AMC and NIN, Amsterdam
- Gba2 as target for pharmacological intervention in Niemann Pick type C (A. Marques)
- Bitter iminosugars and hypothalamic regulation of metabolism (D. Herrera Moro)
- Lysosomal stress and metabolic syndrome (T. Gabriel)
- Biochemical investigations on Fabry disease (M.J. Ferraz)
- Protein biomarkers for ovary cancer (W. Wegdam)
- BAR proteins in Candida albicans (A. Gkoursta)
- Cell biological aspects of IDOL (J.K. Nelson)