Research projects

At Medical Biochemistry in collaboration with Bio-Organic Synthesis, LIC

• Analytical chemistry and biochemistry of glycosphingolipids ( M. Mirzaian)
• Impact of LIMP-2 deficiency on lysosomal glucocerebrosidase (P. Gaspar)
• Lysosomal proteases: a target for Gaucher disease treatment? ( S. Oussoren)
• Endogenous and recombinant human alpha-galactosidase produced in plants ( K. Kytidou)
• Glycosphingolipids and Metabolic Syndrome ( M. van Eijk)
• Zebra fish models of LSDs: screening for therapeutic agents ( W. Kallemeijn & L. Lelieveld)
• Pluripotent stem cells and investigations on lysosomal storage disease ( R. Boot)
• Sphingolipid-based chemical biology probes ( P. Haberkant)
• Intracellular sorting mechanisms for lysosomal proteins ( E. van Meel)
• Novel metabolites formed by transglycosylation
• Activity-based probes for lysosomal glycosidases in biomedical research ( C-L. Kuo)

At Bio-Organic Synthesis (Prof. H.S. Overkleeft)

• Synthesis of labeled complex glycosphingolipids ( P. Wisse)
• Design and synthesis of glycosidase activity based probes ( J. Jiang)
• Design and synthesis of glycosyltransferase inhibitors ( T. Beenakker)
• Iminosugars as glycosidase inhibitors ( B. Liu)

At Macromolecular Biochemistry (Prof. M. Ubbink)

• NMR investigations on glycosidases ( F. Ben Bdira)

Still ongoing at AMC and NIN, Amsterdam

• Gba2 as target for pharmacological intervention in Niemann Pick type C (A. Marques)
• Bitter iminosugars and hypothalamic regulation of metabolism (D. Herrera Moro)
• Lysosomal stress and metabolic syndrome (T. Gabriel)
• Biochemical investigations on Fabry disease (M.J. Ferraz)
• Protein biomarkers for ovary cancer (W. Wegdam)
• BAR proteins in Candida albicans (A. Gkoursta)
• Cell biological aspects of IDOL (J.K. Nelson)