More information about Rolf Boot

Curriculum Vitae

Personal information

Nationality:   Dutch
Date of birth:   4 April 1963

Education

1997   PhD, Medical Biochemistry AMC Amsterdam, University of Amsterdam, 16 October 1997. Thesis title: “Gaucher Disease and Chitotriosidase, Biochemical Investigations”
Advisors: Prof. H.F. Tabak and Dr. J.M.F.G. Aerts
1992   MSc in Biology, University of Amsterdam, The Netherlands

Current and previous research positions

2015 – now    Assistant Professor, Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, The Netherlands
2003 – 2014   Assistant Professor, Medical Biochemistry, AMC Amsterdam, University of Amsterdam, The Netherlands
1997 – 2003   Postdoctoral researcher, AMC Amsterdam, University of Amsterdam, The Netherlands

Contribution to teaching and supervision

• Courses for MSc Chemistry and MSc Life Science and Technology
• Courses for BSc Chemistry and Life Science and Technology
• Courses for Pre-University College at Leiden University

Co-supervision of 7 PhD students and 2 postdoctoral fellows since 2010.

Other responsibilities

• Reviewer several journals

Publication record including five recent representative publications

H-index 46 (Web of Science)

Full publication record: Leiden University

• Lelieveld LT, Gerhardt S, Maas S, Zwiers KC, de Wit C, Beijk EH, Ferraz MJ, Artola M, Meijer AH, Tudorache C, Salvatori D, Boot RG, Aerts JMFG. Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish. J Lipid Res. 2022, 63(5). DOI: 10.1016/j.jlr.2022.100199

• Aerts JMFG, Artola M, van Eijk M, Ferraz MJ, Boot RG. Glycosphingolipids and Infection. Potential New Therapeutic Avenues. Front Cell Dev Biol. 2019;7:324. DOI: 10.3389/fcell.2019.00324

• Lelieveld LT, Mirzaian M, Kuo CL, Artola M, Ferraz MJ, Peter REA, Akiyama H, Greimel P, van den Berg RJBHN, Overkleeft HS, Boot RG, Meijer AH, Aerts JMFG. Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish. J Lipid Res. 2019;60(11):1851-1867. DOI: 10.1194/jlr.ra119000154

• Boer DE, Mirzaian M, Ferraz MJ, Zwiers KC, Baks MV, Hazeu MD, Ottenhoff R, Marques ARA, Meijer R, Roos JCP, Cox TM, Boot RG, Pannu N, Overkleeft HS, Artola M, Aerts JM. Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions. J Lipid Res. 2021;62:100018. DOI: 10.1194/jlr.RA120001043

• Artola M, Kuo CL, Lelieveld LT, Rowland RJ, van der Marel GA, Codée JDC, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS. Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish. J Am Chem Soc. 2019 Mar 13;141(10):4214-4218. DOI: 10.1021/jacs.9b00056

   

Publications