Expertise

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

The available expertise extends across length scales facilitating an understanding of structure-function relationships at both the molecular and the cellular level. This naturally combines approaches from molecular microbiology, genetics, microscopy, biochemistry, structural biology and biophysics.

Structure and function of proteins, nucleic acids and protein-nucleic acid complexes

Atomic force microscopy
Cryo-electron microscopy
NMR
X-ray crystallography
TIRF microscopy
Tethered Particle Motion
Optical tweezers
Chromatography, light scattering, biolayer interferometry and thermal stability

Genomics and proteomics

ChIP-seq
RNA-seq
Chromosome Conformation Capture (3C, HiC)
Comparative genomics and whole genome sequencing – quantitative (phospho)proteomics
Genus-specific amplicon sequencing for genotyping

Structure, morphology and behavior of cells

Cryo-electron tomography
TIRF microscopy
PALM/STORM
Correlative light and electron microscopy
Fluorescent microscopy
Fluorescence time-lapse macroscopy