Steffen Brünle
Universitair docent
- Naam
- Dr. S. Brünle
- Telefoon
- +31 71 527 4544
- s.bruenle@lic.leidenuniv.nl
Meer informatie is beschikbaar op de Engelse profielpagina.
Promovendi
Universitair docent
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Biophysical Structural Chemistry
- Sun J., Boyle A.L., Brünle S. & Ubbink M. (2024), A low-barrier proton shared between two aspartates acts as a conformational switch that changes the substrate specificity of the β-lactamase BlaC, International Journal of Biological Macromolecules 278: 134665.
- Kayastha K., Zhou Y. & Brünle S. (2024), Structural perspectives on chemokine receptors, Biochemical Society Transactions 52(3): 1011-1024.
- Alen I. van, Chikunova A., Zanten D.B. van, Block A.A. de, Timmer M., Brünle S. & Ubbink M. (2023), Asp179 in the class A β‐lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis, FEBS Journal 290: 4933-4949.
- Gruhl T., Weinert T., Rodrigues M.J., Milne C.J., Ortolani G., Nass K., Nango E., Sen S., Johnson P.J.M., Cirelli C., Furrer A., Mous S., Skopintsev P., James D., Dworkowski F., Bath P., Kekilli D., Ozerov D., Tanaka R., Glover H., Bacellar C., Brünle S., Casadei C.M., Diethelm A.D., Gashi D., Gotthard G., Guixa-Gonzalez R., Joti Y., Kabanova V., Knopp G., Lesca E., Ma P., Martiel I., Muhle J., Owada S., Pamula F., Sarabi D., Tejero O., Tsai C.-J., Varma N., Wach A., Boutet S., Tono K., Nogly P., Deupi X., Iwata S., Neutze R., Standfuss J., Schertler G. & Panneels V. (2023), Ultrafast structural changes direct the first molecular events of vision, Nature 615: 939-944.
- Wranik M., Weinert T., Slavov C., Masini T., Furrer A., Gaillard N., Gioia D., Ferrarotti M., James D., Glover H., Carrillo M., Kekilli D., Stipp R., Skopintsev P., Brunle S., Muhlethaler T., Beale J., Gashi D., Nass K., Ozerov D., Johnson P.J.M., Cirelli C., Bacellar C., Braun M., Wang M., Dworkowski F., Milne C., Cavalli A., Wachtveitl J., Steinmetz M.O.O. & Standfuss J. (2023), Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography, Nature Communications 14(1): 903.
- Mous S., Gotthard G., Ehrenberg D., Sen S., Weinert T., Johnson P.J.M., James D., Nass K., Furrer A., Kekilli D., Ma P., Brunle S., Casadei C.M., Martiel I., Dworkowski F., Gashi D., Skopintsev P., Wranik M., Knopp G., Panepucci E., Panneels V., Cirelli C., Ozerov D., Schertler G.F.X., Wang M.T., Milne C., Standfuss J., Schapiro I., Heberle J. & Nogly P. (2022), Dynamics and mechanism of a light-driven chloride pump, Science 375(6583): 845-851.
- Skopintsev P., Ehrenberg D., Weinert T., James D., Kar R.K, Johnson P.J.M., Ozerov D., Furrer A., Martiel I., Dworkowski F., Nass K., Knopp G., Cirelli C., Arrell C., Gashi D., Mous S., Wranik M., Gruhl T., Kekilli D., Brünle S., Deupi X., Schertler G.F.X., Benoit R.M., Panneels V., Nogly P., Schapiro I., Milne C., Heberle J. & Standfuss J. (2020), Femtosecond-to-millisecond structural changes in a light-driven sodium pump, Nature 583: 314-318.
- Brünle S., Eisinger M.L., Poppe J., Mills D.J., Langer J.D., Vonck J. & Ermler U. (2019), Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism, Proceedings of the National Academy of Sciences 116(52): 26497-26504.
- Jaeger K., Bruenle S., Weinert T., Guba W., Muehle J., Miyazaki T., Weber M., Furrer A., Haenggi N., Tetaz T., Huang C.Y., Mattle D., Vonach J.M., Gast A., Kuglstatter A., Rudolph M.G., Nogly P., Benz J., Dawson R.J.P. & Standfuss J. (2019), Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7, Cell 178(5): 1222-1230e10.
- Weinert T., Skopintsev P., James D., Dworkowski F., Panepucci E., Kekilli D., Furrer A., Brünle S., Mous S., Ozerov D., Nogly P., Wang M. & Standfuss J. (2019), Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography, Science 365(6448): 61-65.
- Brünle S., Poppe J., Hail R., Demmer U. & Ermler U. (2018), The molybdenum storage protein — A bionanolab for creating experimentally alterable polyoxomolybdate clusters, Journal of Inorganic Biochemistry 189: 172-179.
- Poppe J., Brünle S., Hail R., Wiesemann K., Schneider K. & Ermler U. (2018), The Molybdenum Storage Protein: A solubleATPhydrolysis‐dependent molybdate pump, FEBS Journal 285: 4602-4616.
- Nogly P., Weinert T., James D., Carbajo S., Ozerov D., Furrer A., Gashi D., Borin V., Skopintsev P., Jaeger K., Nass K., Båth P., Bosman R., Koglin J., Seaberg M., Lane T., Kekilli D., Brünle S., Tanaka T., Wu W., Milne C., White T., Barty A. Weierstall U., Panneels V., Nango E., Iwata S., Hunter M., Schapiro I., Schertler G., Neutze R. & Standfuss J. (2018), Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser, Science 361(6398): eaat0094.
- Weinert T., Olieric N., Cheng R., Brünle S., James D., Ozerov D., Gashi D., Vera L., Marsh M., Jaeger K., Dworkowski F., Panepucci E., Basu S., Skopintsev P., Doré A.S., Geng T., Cooke R.M., Liang M., Prota A.E., Panneels V., Nogly P., Ermler U., Schertler G., Hennig M., Steinmetz M.O., Wang M. & Standfuss J. (2017), Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons, Nature Communications 8: 542.
- Konjik V., Brünle S., Demmer U., Vanselow A., Sandhoff R., Ermler U. & Mack M. (2016), The Crystal Structure of RosB: Insights into the Reaction Mechanism of the First Member of a Family of Flavodoxin-like Enzymes, Angewandte Chemie - International Edition in English 56(4): 1146-1151.
- Konjik V., Brünle S., Demmer U., Vanselow A., Sandhoff R., Ermler U. & Mack M. (2016), Die Kristallstruktur von RosB: Einblicke in den Reaktionsmechanismus des ersten Mitglieds einer flavodoxinähnlichen Enzymfamilie, Angewandte Chemie 129(4): 1166-1171.