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Steffen Brünle
Universitair docent
- Naam
- Dr. S. Brünle
- Telefoon
- +31 71 527 4544
- s.bruenle@lic.leidenuniv.nl
Meer informatie is beschikbaar op de Engelse profielpagina.
Promovendi
Universitair docent
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Biophysical Structural Chemistry
- Alen I. van, Chikunova A., Zanten D.B. van, Block A.A. de, Timmer M., Brünle S. & Ubbink M. (2023), Asp179 in the class A β‐lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis, FEBS Journal 290: 4933-4949.
- Mous S., Gotthard G., Ehrenberg D., Sen S., Weinert T., Johnson P.J.M., James D., Nass K., Furrer A., Kekilli D., Ma P., Brunle S., Casadei C.M., Martiel I., Dworkowski F., Gashi D., Skopintsev P., Wranik M., Knopp G., Panepucci E., Panneels V., Cirelli C., Ozerov D., Schertler G.F.X., Wang M.T., Milne C., Standfuss J., Schapiro I., Heberle J. & Nogly P. (2022), Dynamics and mechanism of a light-driven chloride pump, Science 375(6583): 845-851.
- Skopintsev P., Ehrenberg D., Weinert T., James D., Kar R.K, Johnson P.J.M., Ozerov D., Furrer A., Martiel I., Dworkowski F., Nass K., Knopp G., Cirelli C., Arrell C., Gashi D., Mous S., Wranik M., Gruhl T., Kekilli D., Brünle S., Deupi X., Schertler G.F.X., Benoit R.M., Panneels V., Nogly P., Schapiro I., Milne C., Heberle J. & Standfuss J. (2020), Femtosecond-to-millisecond structural changes in a light-driven sodium pump, NATURE 583: 314-318.
- Brünle S., Eisinger M.L., Poppe J., Mills D.J., Langer J.D., Vonck J. & Ermler U. (2019), Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism, Proceedings of the National Academy of Sciences 116(52): 26497-26504.
- Weinert T., Skopintsev P., James D., Dworkowski F., Panepucci E., Kekilli D., Furrer A., Brünle S., Mous S., Ozerov D., Nogly P., Wang M. & Standfuss J. (2019), Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography, Science 365(6448): 61-65.
- Jaeger K., Bruenle S., Weinert T., Guba W., Muehle J., Miyazaki T., Weber M., Furrer A., Haenggi N., Tetaz T., Huang C.Y., Mattle D., Vonach J.M., Gast A., Kuglstatter A., Rudolph M.G., Nogly P., Benz J., Dawson R.J.P. & Standfuss J. (2019), Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7, Cell 178(5): 1222-1230e10.
- Poppe J., Brünle S., Hail R., Wiesemann K., Schneider K. & Ermler U. (2018), The Molybdenum Storage Protein: A solubleATPhydrolysis‐dependent molybdate pump, FEBS Journal 285: 4602-4616.
- Nogly P., Weinert T., James D., Carbajo S., Ozerov D., Furrer A., Gashi D., Borin V., Skopintsev P., Jaeger K., Nass K., Båth P., Bosman R., Koglin J., Seaberg M., Lane T., Kekilli D., Brünle S., Tanaka T., Wu W., Milne C., White T., Barty A. Weierstall U., Panneels V., Nango E., Iwata S., Hunter M., Schapiro I., Schertler G., Neutze R. & Standfuss J. (2018), Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser, Science 361(6398).
- Brünle S., Poppe J., Hail R., Demmer U. & Ermler U. (2018), The molybdenum storage protein — A bionanolab for creating experimentally alterable polyoxomolybdate clusters, Journal of Inorganic Biochemistry 189: 172-179.
- Weinert T., Olieric N., Cheng R., Brünle S., James D., Ozerov D., Gashi D., Vera L., Marsh M., Jaeger K., Dworkowski F., Panepucci E., Basu S., Skopintsev P., Doré A.S., Geng T., Cooke R.M., Liang M., Prota A.E., Panneels V., Nogly P., Ermler U., Schertler G., Hennig M., Steinmetz M.O., Wang M. & Standfuss J. (2017), Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons, Nature Communications 8: 542.
- Konjik V., Brünle S., Demmer U., Vanselow A., Sandhoff R., Ermler U. & Mack M. (2016), Die Kristallstruktur von RosB: Einblicke in den Reaktionsmechanismus des ersten Mitglieds einer flavodoxinähnlichen Enzymfamilie, Angewandte Chemie 129(4): 1166-1171.
- Konjik V., Brünle S., Demmer U., Vanselow A., Sandhoff R., Ermler U. & Mack M. (2016), The Crystal Structure of RosB: Insights into the Reaction Mechanism of the First Member of a Family of Flavodoxin-like Enzymes, Angewandte Chemie - International Edition in English 56(4): 1146-1151.