Somayah Elsayed
Universitair docent
- Naam
- Dr. S.S.M.A. Elsayed Ph.D.
- Telefoon
- +31 71 527 4561
- s.elsayed@biology.leidenuniv.nl
- ORCID iD
- 0000-0003-3837-6137
Voor meer informatie, zie de Engelse versie.
Promovendi
Nieuws
Universitair docent
- Wiskunde en Natuurwetenschappen
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Machushynets V., Al Ayed K., Terlouw R., Du C., Buijs P., Willemse J., Elsayed S., Schill J., Trebosc V.: Pieren M., Alexander F.M., Cochrane S.A., Liles M.R., Medema M.H., Martin N.I. & Wezel G.P. van (2024), Discovery and derivatization of tridecaptin antibiotics with altered host specificity and enhanced bioactivity, ACS Chemical Biology 19(5): 1106-1115.
- Nuutila A., Xiao X., Heul H.U. van der, Wezel G.P. van Dinis P., Elsayed S.S.M.A. & Metsä-Ketelä M. (2024), Divergence of classical and C-Ring-Cleaved Angucyclines: Elucidation of early tailoring steps in Lugdunomycin and Thioangucycline biosynthesis, ACS Chemical Biology 19(5): 1131-1141.
- Al Ayed U.K., Zamarbide Losada S.D., Machushynets N.V., Terlouw B., Elsayed S.S.M.A., Shill J., Trebos V., Pieren M., Medema M.H., Wezel G.P. van & Martin N.I. (2023), Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability, ACS infectious diseases 9(4): 739-748.
- Elsayed S.S.M.A., Heul H.U. van der, Xiao X., Nuutila A., Baars L.R., Wu C., Metsä-Ketelä M. & Wezel G.P. van (2023), Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis, Communications Chemistry 6: 281.
- Meij A. van der, Elsayed S.S.M.A., Willemse J.J., Du C., Wood T.M., Martin N.I., Raaijmakers J.M. & Wezel G.P. van (2023), The plant stress hormone jasmonic acid evokes defensive responses in streptomycetes, Applied and Environmental Microbiology 89(11): e01239-23.
- Jansma J., Thome N.U., Schwalbe M., Chrysovalantou Chatziioannou A., Elsayed S.S.M.A., Wezel G.P. van, Abbeele P. van den, Hemert S. van & El Aidy S. (2023), Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach, Gut Microbes 15(1): 2232506.
- Bergeijk D.A. van, Elsayed S.S.M.A., Du C., Nuñez Santiago I., Roseboom A.M., Zhang L., Carrion Bravo V.J., Spaink H.P. & Wezel G.P. van (2022), The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces, Communications Chemistry 5: 14.
- Machushynets N.V., Elsayed S.S.M.A., Du C., Siegler M.A., Cruz M. de la, Genillou O., Hankemeier T. & Wezel G.P. van (2022), Discovery of actinomycin L, a new member of the actinomycin family of antibiotics, Scientific Reports 12: 2813.
- Elsayed S.S., Genta-Jouve G., Carrion V.J., Nibbering P.H., Siegler M.A., Boer W., Hankemeier T. & Wezel G.P. van (2020), Atypical spirotetronate polyketides identified in the underexplored genus streptacidiphilus, Journal of Organic Chemistry (JOC) 85(16): 10648-10657.
- Xiao X., Elsayed S.S.M.A., Wu C., Heul H.U. van der, Metsä-Ketelä M., Du C., Prota A.E., Chen C.C., Liu W., Guo R.T., Abrahams J.P. & Wezel G.P. van (2020), Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway, ACS Chemical Biology 15(9): 2529-2538.
- Kloosterman A.M., Cimermancic P., Elsayed S.S.M.A., Du C., Hadjithomas M., Donia M.S., Fischbach M.A., Wezel G.P. van & Medema M.H. (2020), Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides, PLoS Biology 18(12): e3001026.
- Machushynets N.V., Wu C., Elsayed S.S., Hankemeier T. & Wezel G.P. van (2019), Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27, Journal of Industrial Microbiology and Biotechnology 46(3-4): 483-492.
- Carrión V.J., Perez-Jaramillo J., Cordovez V., Tracanna V., Hollander M. de, Ruiz-Buck D., Mendes L.W., Ijcken W.F.J. van, Gomez-Exposito R., Elsayed S.S., Mohanraju P., Arifah A., Oost J. van der, Paulson J.N., Mendes R., Wezel G.P. van, Medema M.H. & Raaijmakers J.M. (2019), Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome, Science 366(6465): 606-612.
- Huang S., Tabudravu J., Elsayed S.S.M.A., Travert J., Peace D., Tong M.G., Kyeremeh K., Kelly S.M., Trembleau L., Ebel R., Jaspars M., Yu Y. & Deng H. (2015), Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins, Angewandte Chemie (International Edition) 54(43): 12697-12701.
- Elsayed S.S.M.A., Trusch F., Deng H., Raab A., Prokes I., Busarakam K., Asenjo J.A., Andrews B.A., West P. van, Bull A.T., Goodfellow M., Yu Y., Ebel R., Jaspars M. & Rateb M.E. (2015), Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert, Journal of Organic Chemistry (JOC) 80(20): 10252-10260.
- Huang S., Elsayed S.S.M.A., Lv M., Tabudravu J., Rateb M.E., Gyampoh R., Kyeremeh K., Ebel R., Jaspars M., Deng Z., Yu Y. & Deng H. (2015), Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps, Chemistry & Biology 22(12): 1633-1642.
- Hamdy A.A., Aboutabl E.A., Elsayed S.S.M.A., Hussein A.A., Díaz-Marrero A.R., Darias J. & Cueto M. (2009), 3-Keto-22-epi-28-nor-cathasterone, a brassinosteroid-related metabolite from Cystoseira myrica, Steroids 74(12): 927-930.