Peter Bouwman
Universitair docent
- Naam
- Dr. R.J.P. Bouwman
- Telefoon
- 071 5276105
- r.j.p.bouwman@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-9252-5896
Voor meer informatie zie de Engelse profielpagina
Universitair docent
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Toxicology
- Niemeijer M.C., Więcek W., Fu S., Huppelschoten S., Bouwman R.J.P., Baze A., Parmentier C., Richert L., Paules R.S., Bois F.Y. & Water B. van de (2024), Mapping interindividual variability of toxicodynamics using high-throughput transcriptomics and primary human hepatocytes from fifty donors, Environmental Health Perspectives 132(3): 37005.
- Noord V.E. van der, Stel W. van der, Louwerens G., Verhoeven D., Kuiken H.J., Lieftink C., Grandits M., Ecker G.F., Beijersbergen R.L., Bouwman R.J.P., Le Dévédec S.E. & Water B. van de (2023), Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors, Breast Cancer Research 25(1): 51.
- Audebert M., Assmann A.S., Azqueta A., Babica P., Benfenati E., Bortoli S., Bouwman R.J.P., Braeuning A., Burgdorf T., Coumoul X., Debizet K., Dusinska M., Ertych N., Fahrer J., Fetz V., Le Hégarat L., López de Cerain A., Heusinkveld H.J., Hogeveen K., Jacobs M.N., Luijten M., Raitano G., Recoules C., Rundén-Pran E., Saleh M., Sovadinová I., Stampar M., Thibol L., Tomkiewicz C., Vettorazzi A., Water B. van de, El Yamani N., Zegura B. & Oelgeschläger M. (2023), New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project, Frontiers in Toxicology 5: 1220998.
- Danilyuk T.Y., Niemeijer M.C., Wijaya L.S., Snijders K., Berk L. van der, Braak S.J. ter, Callegaro G., Bouwman R.J.P., Le Dévédec S.E. & Water B. van de (2023), Human-induced pluripotent stem cell reporters for high-content screening of stress response activation identifying target organ-specific toxicities, Toxicology Letters 384: S192.
- Braak S.J. ter, Niemeijer M.C., Wolters L., Le Dévédec S.E., Bouwman R.J.P. & Water B. van de (2022), Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters, Mutagenesis 37(2): 130-142.
- Duijndam B.H.A., Tedeschi M., Stel W. van der, Hoorn T. van den, Burg B. van der, Bouwman R.J.P., Laan J.W. van der & Water B. van der (2022), Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals, Toxicology In Vitro 81: 105348.
- Ratz L., Brambillasca C.S., Bartke L., Huetzen M.A., Goergens J., Leidecker O., Jachimowicz R.D., Ven M. van de, Proost N., Siteur B., Korte-Grimmerink R. de, Bouwman R.J.P., Pulver E.M., Bruijn R. de, Isensee J., Hucho T., Pandey G., Lohuizen M., Mallmann P., Reinhardt H.C., Jonkers J.M.M. & Puppe J. (2022), Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer, Breast Cancer Research 24(1): 41.
- Bouwman R.J.P., Heijden I. van der, Gulden H. van der, Bruijn R. de, Braspenning M.E., Moghadasi S., Wessels L.F.A., Vreeswijk M.P.G. & Jonkers J.M.M. (2022), Correction: Functional categorization of BRCA1 variants of uncertain clinical significance in homologous recombination repair complementation assays (vol 26, pg 4559, 2020), Clinical Cancer Research 28(20): 4588.
- Wijaya L.S., Trairatphisan P., Gabor A., Niemeijer M.C., Keet J., Alcalà Morera A., Snijders K.E., Wink S., Yang H., Schildknecht S., Stevens J.L., Bouwman R.J.P., Kamp H., Hengstler J., Beltman J.B., Leist M., Le Dévédec S.E., Saez-Rodriguez J. & Water B. van de (2021), Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury, Biochemical Pharmacology 190: 114591.
- Duijndam B., Goudriaan A., Hoorn T. van den, Stel W. van der, Le Dévédec S.E., Bouwman R.J.P., Laan J.W. van der & Water B. van de (2021), Physiologically relevant estrogen receptor alpha pathway reporters for single-cell imaging-based carcinogenic hazard assessment of estrogenic compounds, Toxicological Sciences 181(2): 187-198.
- Snijders K.E., Fehér A., Táncos Z., Bock I., Téglási A., Berk L. van den, Niemeijer M., Bouwman P., Le Dévédec S.E., Moné M.J., Rossom R. van, Kumar M., Wilmes A., Jennings P., Verfaillie C.M., Kobolák J., Braak B. ter, Dinnyés A. & Water B. van de (2021), Fluorescent tagging of endogenous heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages, Archives of Toxicology 95(10): 3285-3302.
- Bouwman P., Heijden I. van der, Gulden H. van der, Bruijn R. de, Braspenning M.E., Moghadasi S., Wessels L.F., Vreeswijk M.P. & Jonkers J. (2020), Functional Categorization of BRCA1 Variants of Uncertain Clinical Significance in Homologous Recombination Repair Complementation Assays, Clinical Cancer Research 26(17): 4559--4568.
- Francica P., Mutlu M., Blomen V.A., Oliveira C., Nowicka Z., Trenner A., Gerhards N.M., Bouwman P., Stickel E., Hekkelman M.L., Lingg L., Klebic I., Van de Ven M., De Korte-Grimmerink R., Howald D., Jonkers J., Sartori A.A., Fendler W., Chapman J.R., Brummelkamp T. & Rottenberg S. (2020), Functional radiogenetic profiling implicates ERCC6L2 in non-homologous end joining, Cell Reports 32(8): 108068.
- Monteiro A.N., Bouwman P., Kousholt A.N., Eccles D.M., Millot G.A., Masson J.Y., Schmidt M.K., Sharan S.K., Scully R., Wiesmüller L., Couch F. & Vreeswijk M.P.G. (2020), Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation, Journal of Medical Genetics 57: 509-518.
- Barazas M., Gasparini A., Huang Y., Küçükosmanoğlu A., Annunziato S., Bouwman R.J.P., Sol W., Kersbergen A., Proost N., Korte-Grimmerink R. de, Ven M. van de, Jonkers J., Borst G.R. & Rottenberg S. (2019), Radiosensitivity is an acquired vulnerability of PARPi-resistant BRCA1-deficient tumors, Cancer Research 79(3): 452-460.
- Pantelidou C., Sonzogni O., De Oliveria Taveira M., Mehta A.K., Kothari A., Wang D., Visal T., Li M.K., Pinto J., Castrillon J.A., Cheney E.M., Bouwman R.J.P., Jonkers J., Rottenberg S., Guerriero J.L., Wulf G.M. & Shapiro G.I. (2019), T-cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer, Cancer Discovery 9(6): 722-737.
- Drost R., Dhillon K.K., Gulden H. van der, Heijden I. van der, Brandsma I., Cruz C., Chondronasiou D., Castroviejo-Bermejo M., Boon U., Schut E., Burg E.van der, Wientjens E., Pieterse M., Klijn C., Klarenbeek S., Loayza-Puch F., Elkon R., Van Deemter L., Rottenberg S., Ven van de, M., Dekkers D.H., Demmers J.A., Gent D.C. van, Agami R., Balmaña J., Serra V., Taniguchi T., Bouwman R.J.P. & Jonkers J. (2016), BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1, Journal of Clinical Investigation 126(8): 2903-2918.
- Badie S., Carlos A.R., Folio C., Okamoto K., Bouwman P., Jonkers J. & Tarsounas M. (2015), BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres, The EMBO Journal 34(3): 410-424.
- Xu G., Chapman J.R., Brandsma I., Yuan J., Mistrik M., Bouwman P., Bartkova J., Gogola E., Warmerdam D., Barazas M., Jaspers J.E., Watanabe K., Pieterse M., Kersbergen A., Sol W., Celie P.H.N., Schouten P.C., Broek B. van den, Salman A., Nieuwland M., Rink I. de, Ronde J. de, Jalink K., Boulton S.J., Chen J., Gent D.C. van, Bartek J., Jonkers J., Borst P. & Rottenberg S. (2015), REV7 counteracts DNA double-strand break resection and affects PARP inhibition, Nature 521(7553): 541-544.
- Gu Y., Bouwman R.J.P., Greco D., Saarela J., Yadav B., Jonkers J. & Kuznetsov S.G. (2014), Suppression of BRCA1 sensitizes cells to proteasome inhibitors, Cell Death and Disease 5: e1580.
- Bouwman P., Gulden H. van der, Heijden I. van der, Drost R., Klijn C.N., Prasetyanti P., Pieterse M., Wientjens E., Seibler J., Hogervorst F.B. & Jonkers J. (2013), A high-throughput functional complementation assay for classification of BRCA1 missense variants, Cancer Discovery 3(10): 1142-1155.
- Gorrini C., Baniasadi P.S., Harris I.S., Silvester J., Inoue S., Snow B., Joshi P.A., Wakeham A., Molyneux S.D., Martin B., Bouwman P., Cescon D.W., Elia A.J., Winterton-Perks Z., Cruickshank J., Brenner D., Tseng A., Musgrave M., Berman H.K., Khokha R., Jonkers J., Mak T.W. & Gauthier M.L. (2013), BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival, The Journal of Experimental Medicine 210(8): 1529-1544.
- Carlos A.R., Escandell J.M., Kotsantis P., Suwaki N., Bouwman P., Badie S., Folio C., Benitez J., Gomez-Lopez G., Pisano D.G., Jonkers J. & Tarsounas M. (2013), ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets, Nature Communications 4: 2697.
- Sotiropoulou P.A., Karambelas A.E., Debaugnies M., Candi A., Bouwman P., Moers V., Revenco T., Rocha A.S., Sekiguchi K., Jonkers J. & Blanpain C. (2013), BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny, Genes & Development 27(1): 39-51.
- Bowman-Colin C., Xia B., Bunting S., Klijn C., Drost R., Bouwman P., Fineman L., Chen X., Culhane A.C., Cai H., Rodig S.J., Bronson R.T., Jonkers J., Nussenzweig A., Kanellopoulou C. & Livingston D.M. (2013), Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer, Proceedings of the National Academy of Sciences 110(21): 8632-8637.
- Drost R., Bouwman R.J.P., Rottenberg S., Boon U., Schut E., Klarenbeek S., Klijn C., Van der Heijden I., Van der Gulden H., Wientjens E., Pieterse M., Catteau A., Green P., Solomon E., Morris J.R. & Jonkers J. (2011), BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance, Cancer Cell 20(6): 797-809.
- Bouwman P., Aly A., Escandell J.M., Pieterse M., Bartkova J., Van der Gulden H., Hiddingh S., Thanasoula M., Kulkarni A., Yang Q., Haffty B.G., Tommiska J., Blomqvist C., Drapkin R., Adams D.J., Nevanlinna H., Bartek J., Tarsounas M., Ganesan S. & Jonkers J. (2010), 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers, Nature Structural and Molecular Biology 17(6): 688-695.
- Evers B., Schut E., Van der Burg E., Braumuller T.M., Egan D.A., Holstege H., Edser P., Adams D.J., Wade-Martins R., Bouwman P. & Jonkers J. (2010), A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors, Clinical Cancer Research 16(1): 99-108.
- Badie S., Escandell J.M., Bouwman P., Carlos A.R., Thanasoula M., Gallardo M.M., Suram A., Jaco I., Benitez J., Herbig U., Blasco M.A., Jonkers J. & Tarsounas M. (2010), BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping, Nature Structural and Molecular Biology 17(12): 1461-1469.
- Bouwman R.J.P., Göllner H., Elsässer H.P., Eckhoff G., Karis A., Grosveld F., Philipsen S. & Suske G. (2000), Transcription factor Sp3 is essential for post-natal survival and late tooth development, The EMBO Journal 19(4): 655-61.