Nora Goosen
Extern lid examencommissie BSc LST
- Naam
- Dr. N. Goosen
- Telefoon
- +31 71 527 2727
- n.goosen@lic.leidenuniv.nl
Extern lid examencommissie BSc LST
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Opleidingen
- LIC/OPL/Opleidingen BSc LST & MST
- Kytidou K., Beekwilder J., Artola M., Meel E. van, Wilbers R.H.P., Moolenaar G.F., Goosen N., Ferraz M.J., Katzy R., Voskamp P., Florea B.I., Hokke C.H., Overkleeft H.S., Schots A., Bosch D., Pannu N. & Aerts J.M.F.G. (2018), Nicotiana benthamiana α-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease, Journal of Biological Chemistry 293(26): 10042-10058.
- Kytidou K., Beenakker T.J.M., Westerhof L.B., Hokke C.H., Moolenaar G.F., Goosen N., Mirzaian M., Guimaraes da Lomba Ferraz M.J., Geus M.A.R. de, Kallemeijn W.W., Overkleeft H.S., Boot R.G., Schots A., Bosch D. & Aerts J.M.F.G. (2017), Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease, Frontiers in Plant Science 8: 1026.
- Krishnan M., Moolenaar G.F., Sai Sankar Gupta K.B., Goosen N. & Pandit A. (2017), Large-scale in vitro production, refolding and dimerization of PsbS in different microenvironments, Scientific Reports 7: 15200.
- Valk R.A. van der, Vreede J., Qin L., Moolenaar G.F., Hofmann A., Goosen N. & Dame R.T. (2017), Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activity, eLife 6: e27369.
- Urem M., Rossum T. van, Bucca G., Moolenaar G.F., Laing E., Swiatek-Połatynska M.A., Willemse J., Tenconi E., Rigali S., Goosen N., Smith C.P. & Wezel G.P. van (2016), OsdR of Streptomyces coelicolor and the dormancy regulator DevR of Mycobacterium tuberculosis control overlapping regulons, mSphere 1(3): e00014.
- Driessen R.P.C., Lin S.N., Waterreus W.J., Meulen A.L.H. van der, Valk R.A. van der, Laurens N., Moolenaar G.F., Pannu N.S., Wuite G.J.L., Goosen N. & Dame R.T. (2016), Diverse architectural properties of Sso10a proteins: Evidence for a role in chromatin compaction and organization, Scientific Reports 6: 29422.
- Driessen R.P.C., Sitters G., Laurens N., Moolenaar G.F., Wuite G.J.L., Goosen N. & Dame R.T. (2014), Effect of temperature on the intrinsic flexibility of DNA and its interaction with architectural proteins, Biochemistry 53(41): 6430-6438.
- Meulenbroek E.M., Cane C.P., Jala I., Iwai S., Moolenaar G.F., Goosen N. & Pannu N.S. (2013), UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions, Nucleic Acids Research 41(2): 1363-1371.
- Driessen R.P.C., Valk R.A. van der, Moolenaar G.F., Goosen N. & Dame R.T. (2013), The Architects of the Archaeal Chromatin, Biophysical Journal 104(2): 581A-581A.
- Wagner K., Moolenaar G.F. & Goosen N. (2011), Role of the insertion domain and the zinc-finger motif of Escherichia coli UvrA in damage recognition and ATP hydrolysis, DNA Repair 10(5): .
- Goosen N. (2010), Nucleotide excision repair in eukaryotes. In: , Encyclopedia of Biological Chemistry. Encyclopedia of Biological Chemistry.
- Goosen N. (2010), Scanning the DNA for damage by the nucleotide excision repair machinery, DNA Repair 9(5): .
- Wagner K., Moolenaar G.F. & Goosen N. (2010), Role of the two ATPase domains of Escherichia coli UvrA in binding non-bulky DNA lesions and interaction with UvrB, DNA Repair 9(11): .
- Meulenbroek E.M., Paspaleva K., Thomassen E.A.J., Abrahams J.P., Goosen N. & Pannu N.S. (2009), Involvement of a carboxylated lysine in UV damage endonuclease, Protein Science 18(3): 549-558.
- Hogendorf W.F.J., Verhagen C.P., Malta E., Goosen N., Overkleeft H., Filippov D.V. & Van der Marel G.A. (2009), The synthesis of a menthol derivative of 2-aminopurine as a fluorescent DNA lesion, Tetrahedron 65(50): 10430-10435.
- Pakotiprapha D., Inuzuka Y., Bowman B., Moolenaar G.F., Goosen N., Jeruzalmi D. & Verdine G.L. (2008), Crystal Structure of Bacillus stearothermophilus UvrA Provides Insight into ATP-modulated, Molecular and Cellular Biology 26: 122-133.
- Pakotiprapha D., Inuzuka Y., Bowman B., Moolenaar G.F., Goosen N., Jeruzalmi D. & Verdine G.L. (2008), Crystal Structure of Bacillus stearothermophilus UvrA Provides Insight into ATP-modulated Dimerization, UvrB Interaction and DNA Binding, Molecular Cell 26: 122-133.
- Malta E., Verhagen C.P., Moolenaar G.F., Filippov D.V., Marel G.A. van der & Goosen N. (2008), Functions of base flipping in E. coli nucleotide excision repair, DNA Repair 7: 1647-1658.
- Goosen N. & Moolenaar G.F. (2008), Repair of UV damage in bacteria, DNA Repair 7: 353-379.
- Malta E., Moolenaar G.F. & Goosen N. (2007), Dynamics of the UvrABC Nucleotide Excision Repair Proteins analyzed by Fluorescence Resonance Energy Transfer, Biochemistry 46: 9080-9088.
- Thomassen E.A.J., Paspaleva K.K., Pannu N.S., Iwai S., Moolenaar G.F. & Goosen N. (2007), Crystal structure of the DNA repair enzyme UV damage endonuclease, 15: 1316-1324.
- Paspaleva K., Thomassen E., Pannu N.S., Iwai S., Moolenaar G.F., Goosen N. & Abrahams J.P. (2007), Crystal structure of the DNA repair enzyme ultraviolet damage endonuclease, Structure 15(10): 1316-1324.
- Malta E., Moolenaar G.F. & Goosen N. (2006), Base flipping in nucleotide excision repair, Journal of Biological Chemistry 281(4): 2184-2194.
- Smeets L., Barcak G., Vandenbroucke-Grauls C.M.J.E., Bitter W. & Goosen N. (2006), Functional characterization of the competence protein DprA/SMF in Escherichia coli, FEMS Microbiology Letters 236: 223-228.
- Moolenaar G.F., Schutte M. & Goosen N. (2005), Binding of the UvrB dimer to non-damaged and damaged DNA: residues Y92 and Y93 influence the stability of both subunits, DNA Repair 4: 699-713.
- Noort J. van, Verbrugge S., Goosen N., Dekker C. & Dame R.T. (2004), Dual architectural roles of HU: Formation of flexible hinges and rigid filaments, Proceedings of the National Academy of Sciences 101(18): 6969-6974.
- Dame R.T., Wyman C. & Goosen N. (2003), Insights into the relation of transcription by scanning force microscopy, Journal of Microscopy 212: 244-253.
- Dame R.T., Wyman C., Wurm R., Wagner R. & Goosen N. (2002), Structural basis for H-NS-mediated trapping of RNA polymerase in the open initiation complex at the rrnB P1, Journal of Biological Chemistry 277(3): 2146-2150.
- Dame R.T. & Goosen N. (2002), HU: promoting or counteracting DNA compaction?, FEBS Letters 529(2-3): 151-156.
- Verhoeven E.E.A., Kesteren M.A. van, Turner J.J.C., Marel G.A. van der, Boom J.H. van, Moolenaar G.F. & Goosen N. (2002), The C-terminal region of Escherichia coli UvrC contributes to the flexibility of the UvrABC nucleotide excision repair system, Nucleic Acids Research 30: 2492-2500.
- Goosen N. & Moolenaar G.F. (2001), Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair, Research in Microbiology 152(3-4): 401-409.
- Verhoeven E.E.A., Wyman C., Moolenaar G.F., Hoeijmakers J.H.J. & Goosen N. (2001), Architecture of nucleotide excision repair complexes: DNA is wrapped by UvrB before and after damage recognition, The EMBO Journal 20(3): 601-611.
- Dame R.T., Wyman C. & Goosen N. (2001), Structural basis for preferential binding of H-NS to curved DNA, Biochimie 83(2): 231-234.
- Moolenaar G.F., Hoglund L. & Goosen N. (2001), Clue to damage recognition by UvrB: residues in the beta-hairpin structure prevent binding to non-damaged DNA, The EMBO Journal 20(21): 6140-6149.
- Alexandrovich A., Czisch M., Frenkel T.A., Kelly G.P., Goosen N., Moolenaar G.F., Chowdhry B.Z., Sanderson M.R. & Lane A.N. (2001), Solution structure, hydrodynamics and thermodynamics of the UvrB C-terminal domain, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 19(2): 219-236.
- Moolenaar G.F., Monaco V., Marel G.A. van der, Boom J.H. van, Visse R. & Goosen N. (2000), The effect of the DNA flanking the lesion on formation of the UvrB-DNA preincision complex - Mechanism for the UvrA-mediated loading of UvrB onto a DNA damaged site, Journal of Biological Chemistry 275(11): 8038-8043.
- Verhoeven E.E.A., Kesteren M.A. van, Moolenaar G.F., Visse R. & Goosen N. (2000), Catalytic sites for 3'- and 5' incision of Escherichia coli nucleotide excision repair are both located in UvrC, Journal of Biological Chemistry 275(7): 5120-5123.
- Dame R.T., Wyman C. & Goosen N. (2000), H-NS mediated compaction of DNA visualised by atomic force microscopy, Nucleic Acids Research 28(18): 3504-3510.
- Moolenaar G.F., Herron M.F.P., Monaco V., Marel G.A. van der, Boom J.H. van, Visse R. & Goosen N. (2000), The role of ATP binding and hydrolysis by UvrB during nucleotide excision repair, Journal of Biological Chemistry 275(11): 8044-8050.
- Moolenaar G.F., Moorman C. & Goosen N. (2000), Role of the Escherichia coli nucleotide excision repair protein in DNA replication, Journal of Bacteriology 182(20): 5706-5714.
- Alexandrovich A., Sanderson M., Moolenaar G.F., Goosen N. & Lane N.A. (1999), NMR assignments and secondary structure of the UvrC binding domain of UvrB, FEBS Letters 451: 181-185.
- Monaco V., Wetering K. van de, Meeuweoord N.J., Elst H.A. van den, Stuivenberg H.R., Visse R., Kaaden J. van der, Moolenaar G.F., Verhoeven E.E.A., Goosen N., Marel G.A. van der & Boom J.H. van (1999), Synthesis and biological evaluation of modified DNA fragments for the study of nucleotide excision repair in E. coli, Nucleosides and Nucleotides 18: 1339-1341.
- Sohi M., Alexandrovich A., Moolenaar G.F., Visse R., Goosen N., Vernede X., Fontecilla-Camps J., Champness J. & Sanderson M.R. (1999), Crystal structure of Escherichia coli UvrB C-terminal domain and a model for UvrB-UvrC interaction, FEBS Letters 465: 161-164.
- Goosen N., Moolenaar G.F., Visse R. & Putte P. van de (1998), Functional domains of the Escherichia coli UvrABC proteins in nucleotide excision repair. In: Eckstein F. & Lilley D. (red.), Nucleic Acids & Molecular Biology. Berlin: Springer-Verlag. 103-123.
- Moolenaar G.F., Franken C.L.M.C., Putte P. van de & Goosen N. (1998), Function of the homologous regions of the Escherichia coli DNA excision repair proteins UvrB and UvrC in stabilization of the UvrBC-DNA complex and in 3'-incision, Mutation Research : DNA Repair 385: 195-203.
- Moolenaar G.F., Bazuine M., Knippenberg I.C. van, Visse R. & Goosen N. (1998), Characterization of the Escherichia coli damage-independent UvrBC endonuclease activity, Journal of Biological Chemistry 273(52): 34896-34903.
- Moolenaar G.F., Schoot Uiterkamp R., Zwijnenburg D.A. & Goosen N. (1998), The C-terminal region of the Escherichia coli UvrC protein, which is homologous to the C-terminal region of the human ERCC1 protein is involved in DNA binding and 5'-incision, Nucleic Acids Research 26: 462-468.