Martijn Manson
Universitair docent
- Naam
- Dr. M.L. Manson
- Telefoon
- +31 71 527 6805
- m.l.manson@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-5508-8615
Meer informatie is beschikbaar op de Engelse profielpagina
Universitair docent
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Pharmacology
- Sun M.,Manson M.L., Guo T. & Lange E.C.M. de (2024), CNS viral infections—what to consider for improving drug treatment: a plea for using mathematical modeling approaches, CNS Drugs 38(5): 349-373.
- Jong L.M. de, Harpal C, Berg D. van den., Hoekstra M., Peter N.J., Rissmann R., Swen J.J. & Manson M.L. (2024), CYP and non-CYP drug metabolizing enzyme families exhibit differential sensitivities towards pro-inflammatory cytokine modulation, Drug Metabolism and Disposition 52(12): 1429-1437.
- Jong L.M. de, Boussallami S., Sánchez-López E., Giera M., Tushuizen M.E., Hoekstra M., Hawinkels L.J.A.C., Rissmann R., Swen J.J. & Manson M.L. (2023), The impact of CYP2C19 genotype on phenoconversion by concomitant medication, Frontiers in Pharmacology 14: 1201906.
- Liu F., Aulin L.B.S. & Manson M.L. Krekels E.H.J. Hasselt J.G.C. van (2023), Unraveling the effects of acute inflammation on pharmacokinetics: a model-based analysis focusing on renal glomerular filtration rate and cytochrome P450 3A4-mediated metabolism, European Journal of Drug Metabolism and Pharmacokinetics 48: 623–631.
- Jong L.M. de, Zhang Z., Hartog Y. de, Sijsenaar T.J.P., Martins Cardoso R., Manson M.L., Hankemeier T., Lindenburg P.W., Salvatori D.C.F., Eck M. van & Hoekstra M. (2022), PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice, Scientific Reports 12(1): 483.
- Jong L.M. de, Klomp S.D., Treijtel N., Rissmann R., Swen J.J. & Manson M.L. (2022), A systematic review on disease-drug-drug interactions with immunomodulating drugs: a critical appraisal of risk assessment and drug labelling, British Journal of Clinical Pharmacology 88(10): 4387-4402.
- Klomp S.D. Manson M.L. Guchelaar H. Swen J.J. (2020), Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review, Journal of Clinical Medicine 9(9): 2890.
- Jong L.M. de, Jiskoot W., Swen J.J. & Manson M.L. (2020), Distinct effects of inflammation on Cytochrome p450 regulation and drug metabolism: lessons from experimental models and a potential role for pharmacogenetics, Genes 11(12): 1509.
- Manson M.L. Säfholm J. James A. Johnsson A.K. Bergman P. Al-Ameri M. Orre A.C. Kärrman-Mårdh C. Dahlén S.E. Adner M. (2019), IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways, Journal of Allergy and Clinical Immunology 145(3): 808-817.
- Säfholm J. Manson M.L. Bood J. Al-Ameri M. Orre A.C. Raud J. Dahlén S.E. Adner M. (2019), Mannitol triggers mast cell-dependent contractions of human small bronchi and prostacyclin bronchoprotection, Journal of Allergy and Clinical Immunology 144(4): 984-992.
- Rider C.F., Altonsy M.O., Mostafa M.M., Shah S.V., Sasse S., Manson M.L., Yan D., Kärrman-Mårdh C., Miller-Larsson A.M., Gerber A.N., Giembycz M.A. & Newton R. (2018), Long-acting β2-adrenoceptor agonists enhance glucocorticoid receptor (GR)-mediated transcription by gene-specific mechanisms rather than generic effects via GR, Molecular Pharmacology 94(3): 1031-1046.
- Manson M.L., Rojnik Z., Thorn K., Mardh C.K. & Newton R. (2018), The CREB-Regulated Transcription Coactivators, CRTC2/3, Facilitate the Synergistic Induction of RGS2 by LABAs and Glucocorticoids in Human Bronchial Epithelial Cells. American Journal of Respiratory and Critical Care Medicine. American Thoracic Society , San Diego. 18 mei 2018 - 23 mei 2018. [conferentie poster].
- Marquardt N., Kekalainen E., Chen P., Kvedaraite E., Wilson J.N., Ivarsson M.A., Mjosberg J., Berglin L. & Safholm J. (2017), Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69-CD56dim cells, Journal of Allergy and Clinical Immunology 139(4): 1321-1330.e4.
- Larsson O.J. Manson M.L. Starkhammar M. Fuchs B. Adner M. Georén S.K. Cardell L.O. (2016), The bronchodilatory capacity of imiquimod: the existence of two mechanisms, American Journal of Physiology - Lung Cellular and Molecular Physiology 311(1): L178-L179.
- Larsson O.J. Manson M.L.Starkhammar M. Fuchs B. Adner M. Georén S.K. Cardell L.O. (2016), The TLR7 agonist imiquimod induces bronchodilation via a nonneuronal TLR7-independent mechanism: a possible role for quinoline in airway dilation, American Journal of Physiology 310(11): L1121-L1129.
- Säfholm J., Manson M.L., Bood J., Delin I., Orre A.C., Bergman P., Al-Ameri M., Dahlén S.E. & Adner M. (2015), Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor, Journal of Allergy and Clinical Immunology 136(5): 1232-1239.
- Protudjer J.L.P., Binnmyr J., Grundstrom J., Manson M.L., Marquardt N., Safholm J. & Ullemar V. (2015), Allergy trainees' perspectives on career opportunities: results from a trainee-organized retreat, Allergy 70(11): 1353-1355.
- Manson M.L., Säfholm J., Al-Emeri M., Bergman P., Orre A.C., Sward K., James A., Dahlén S.E. & Adner M. (2014), Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle, European Journal of Pharmacology 740: 302-311.
- Pulkkinen V., Manson M.L., Säfholm J., Adner M. & Dahlén S.E. (2012), The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea, American Journal of Physiology - Lung Cellular and Molecular Physiology 303(11): L956-L966.
- Manson M.L. Derissen E. Wijermans P. Schellens J. Beijnen J. (2011), Demethylating medication in myelodysplastic syndrome: Epigenetics as a target for therapy | Demethylerende medicatie bij myelodysplastisch syndroom, Nederlands Tijdschrift voor Geneeskunde 155(4): A3167.
- Nascholing reviewen astma
- Special Interest Group (SIG) Long