Marta Artola Perez de Azanza
Universitair docent
- Naam
- Dr. M.E. Artola Perez de Azanza
- Telefoon
- +31 71 527 4213
- m.e.artola@lic.leidenuniv.nl
- ORCID iD
- 0000-0002-3051-3902
Promovendi
Universitair docent
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- Ofman T.P., Heming J.J.A., Nin-Hill A., Küllmer F., Moran E., Bennett M., Steneker R., Klein A.M., Ruijgrok G., Kok K., Armstrong Z.W.B., Aerts J.M.F.G., Marel G.A. van der, Rovira C., Davies G.J., Artola M.E., Codée J.D.C. & Overkleeft H.S. Rovira Carme Davies Gideon J. Artola Marta Codée Jeroen D. C. Overkleeft Herman S. (2024), Conformational and electronic variations in 1,2‐ and 1,5a‐Cyclophellitols and their impact on retaining α‐glucosidase inhibition, Chemistry: a European Journal 30(31): e202400723.
- Artola Perez de Azanza M.E., Aerts J.M.F.G., Marel G.A. van der, Rovira C., Codee J.D.C., Davies G.J. & Overkleeft H.S. (2024), From mechanism-based retaining glycosidase inhibitors to activity-based glycosidase profiling, Journal of the American Chemical Society 146(36): 24729-24741.
- Koemans T.S., Bennett M., Guimaraes Da Lomba Ferraz M.J., Armstrong Z.W.B., Artola Perez de Azanza M.E., Aerts J.M.F.G., Codee J.D.C., Overkleeft H.S. & Davies G.J. (2024), Structure-guided design of C3-branched swainsonine as potent and selective human Golgi α-mannosidase (GMII) inhibitor, Chemical Communications : .
- Su Qin Louwerse Max Lammers Rob F. Maurits Elmer Janssen Max Boot Rolf G. Borlandelli Valentina Offen Wendy A. Linzel Daniël Schröder Sybrin P. Davies Gideon J. Overkleeft Herman S. Artola Marta Aerts Johannes M. F. G. (2024), Selective labelling of GBA2 in cells with fluorescent β-D-arabinofuranosyl cyclitol aziridines, Chemical Science 15(37): 15212-15220.
- Bannink S., Bila K.O., Weperen J. van, Ligthart N.A.M., Ferraz M.J., Boot R.G., Vliet D. van der, Boer D.E.C., Overkleeft H.S., Artola M. & Aerts J.M.F.G. (2024), 6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols, Journal of Lipid Research 65(11): 100670.
- Thaler M., Ofman T.P., Kok K., Heming J.J.A., Moran E., Pickles I., Leijs A.A., Nieuwendijk A.M.C.H. van den, Berg R.J.B.H.N. van den, Ruijgrok G., Armstrong Z., Salgado-Benvindo C., Ninaber D.K., Snijder E.J., Boeckel C.A.A. van, Artola M., Davies G.J., Overkleeft H.S. & Hemert M.J. van (2024), Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses, ACS Central Science 10(8): 1594-1608.
- Radchenko Y., Su Q., Schroder S.S., Gijlswijk L. van, Artola M., Aerts J.M.F.G., Codee J.D.C. & Overkleeft H.S. (2024), Synthesis and Biological Evaluation of Deoxycyclophellitols as Human Retaining β-Glucosidase Inhibitors, Chemistry: a European Journal 30(70): e202402988.
- Gracht D. van der, Rowland R.J., Roig-Zamboni V., Guimaraes Da Lomba Ferraz M.J., Louwerse G.A.M., Geurink P.P., Aerts J.M.F.G., Sulzenbacher G., Davies G.J., Overkleeft H.S. & Artola Perez de Azanza M.E. (2023), Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases, Chemical Science 14(34): 9136-9144.
- Males A., Kok K., Nin-Hill A., Koster N. de, Beukel S. van den, Beenakker T.J.M., Marel G.A. van der, Codée J.D.C., Aerts J.M.F.G., Overkleeft H.S., Rovira C., Davies G. & Artola Perez de Azanza M.E. (2023), Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump–hole strategy, Chemical Science 14(46): 13581-13586.
- Borlandelli V.B., Offen W., Moroz O., Nin-Hill A., Mcgregor N., Binkhorst L., Ishiwata A., Armstrong Z., Artola Perez de Azanza M.E., Rovira C., Davies G.J. & Overkleeft H.S. (2023), β-l-arabinofurano-cyclitol aziridines are covalent broad-spectrum inhibitors and activity-based probes for retaining β-l-arabinofuranosidases, ACS Chemical Biology 18(12): 2564-2573.
- Borlandelli V., Armstrong Z., Nin-Hill A., Codée J., Raich L., Artola M., Rovira C., Davies G. & Overkleeft H.S. (2023), 4-O-substituted glucuronic cyclophellitols are selective mechanism-based heparanase inhibitors, ChemMedChem 18(4): e202200580.
- Su Q., Schroder S.P., Lelieveld L.T., Guimaraes Da Lomba Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola Perez de Azanza M.E. & Kuo C.L. (2023), Corrigendum: Xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase, ChemBioChem 24(3): e202300728.
- Lelieveld L.T., Gerhardt S., Maas S., Zwiers K.C., Wit C. de, Beijk E.H., Guimaraes Da Lomba Ferraz M.J., Artola Perez de Azanza M.E., Meijer A.H., Tudorache C., Salvatori D., Boot R.G. & Aerts J.M.F.G. (2022), Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish, Journal of Lipid Research 63(5): 100199.
- Kok K., Kuo C.L., Katzy R.E., Lelieveld L.T., Wu L., Roig-Zamboni V., Marel G.A. van der, Codee J.D.C., Sulzenbacher G., Davies G.J., Overkleeft H.S., Aerts J.M.F.G. & Artola Perez de Azanza M.E. (2022), 1,6-epi-Cyclophellitol cyclosulfamidate is a bona fide lysosomal α-glucosidase stabilizer for the treatment of Pompe disease, Journal of the American Chemical Society 144(32): 14819-14827.
- Chen Y., Armstrong Z., Artola M., Florea B.I., Kuo C.L., Boer C. de, Rasmussen M.S., Abou Hachem M., Marel G.A. van der, Codee J.D.C., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2021), Activity-based protein profiling of retaining alpha-amylases in complex biological samples, Journal of the American Chemical Society 143(5): 2423-2432.
- McGregor N.G.S., Coines J., Borlandelli V.B., Amaki S., Artola M., Nin-Hill A., Linzel D., Yamada C., Arakawa T., Ishiwata A., Ito Y., Marel G.A. van der, Codee J.D.C., Fushinobu S., Overkleeft H.S., Rovira C. & Davies G.J. (2021), Cysteine nucleophiles in glycosidase catalysis: application of a covalent β‐l‐arabinofuranosidase inhibitor, Angewandte Chemie (International Edition) 60(11): 5754-5758.
- Kok K., Zwiers K.C., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Artola M. (2021), Fabry disease: molecular basis, pathophysiology, diagnostics and potential therapeutic directions, Biomolecules 11(2): 271.
- Boer D.E., Mirzaian M., Ferraz M.J., Zwiers K.C., Baks M.V., Hazeu M.D., Ottenhoff R., Marques A.R.A., Meijer R., Roos J.C.P., Cox T.M., Boot R.G., Pannu N., Overkleeft H.S., Artola M. & Aerts J.M.F.G. (2021), Human glucocerebrosidase mediates formation of xylosyl-cholesterol by beta-xylosidase and transxylosidase reactions, Journal of Lipid Research 62: 100018.
- Su Q., Schröder S.P., Lelieveld L.T., Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola M. & Kuo C.L. (2021), Xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase, ChemBioChem 22(21): 3090-3098.
- Rowland R.J., Chen Y., Breen I., Wu L., Offen W.A., Beenakker T.J.M., Su Q., Nieuwendijk A.M.C.H. van den, Aerts J.M.F.G., Artola Perez de Azanza M.E., Overkleeft H.S. & Davies G.J. (2021), Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents, Chemistry: a European Journal 27: 1-13.
- Huecas S., Araujo-Bazan L., Ruiz F.M., Ruiz-Avila L.B., Martinez R.F., Escobar-Pena A., Artola Perez de Azanza M.E., Vazquez-Villa H., Martin-Fontecha M., Fernandez-Tornero C., Lopez-Rodriguez M.L. & Andreu J.M. (2021), Targeting the FtsZ allosteric binding site with a novel fluorescence polarization screen, cytological and structural approaches for antibacterial discovery, Journal of Medicinal Chemistry 64(9): 5730-5745.
- McGregor N.G.S., Artola M., Nin-Hill A., Linzel D., Haon M., Reijngoud J., Ram A., Rosso M.N., Marel G.A. van der, Codée J.D.C., Wezel G.P. van, Berrin J.G., Rovira C., Overkleeft H.S. & Davies G.J. (2020), Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases, Journal of the American Chemical Society 142(10): 4648-4662.
- Kytidou K., Artola M., Overkleeft H.S. & Aerts J.M.F.G. (2020), Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics, Frontiers in Plant Science 11: 357.
- Boer D.E.C., Mirzaian M., Ferraz M.J., Zwiers K.C., Baks M.V., Hazeu M.D., Ottenhoff R., Marques A.R.A., Meijer R., Roos J.P.C., Cox T.M., Boot R.G., Pannu N., Overkleeft H.S., Artola M. & Aerts J.M.F.G. (2020), Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions, Journal of Lipid Research 61(12): jlr.RA120001043.
- McGregor N.G.S., Turkenburg J.P., Krogh K.B.R.M., Nielsen J.E., Artola M., Stubbs K.A., Overkleeft H.S. & Davies G.J. (2020), Structure of a GH51 α-L-arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi, Acta Crystallographica Section D Structural Biology 76(11): 1124-1133.
- Artola M., Kuo C.L., Lelieveld L.T., Rowland R.J., Marel G.A. van der, Codée J.D.C., Boot R.G., Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2019), Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish, Journal of the American Chemical Society 141(10): 4214-4218.
- Wu L., Armstrong Z., Schröder S.P., Boer C. de, Artola M., Aerts J.M.F.G., Overkleeft H.S. & Davies G.J. (2019), An overview of activity-based probes for glycosidases, Current Opinion in Chemical Biology 53: 25-36.
- Lelieveld L.T., Mirzaian M., Kuo C.L., Artola Perez de Azanza M.E., Guimaraes da Lomba Ferraz M.J., Peter R.E.A., Akiyama H., Greimel P., Berg R.J.B.H.N. van den, Overkleeft H.S., Boot R.G., Meijer A. & Aerts J.M.F.G. (2019), Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish, Journal of Lipid Research 60(11): 1851-1867.
- Artola M., Hedberg C., Rowland R.J., Raich L., Kytidou K., Wu L., Schaaf A., Ferraz M.J., Marel G.A. van der, Codee J.D.C., Rovira C., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2019), Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease, Chemical Science 10(40): 9233-9243.
- Jariwala P.B., Pellock S.J., Goldfarb D., Cloer E.W., Artola M., Simpson J.B., Bhatt A.P., Walton W.G., Roberts L.R., Major M.B., Davies G.J., Overkleeft H.S. & Redinbo M.R. (2019), Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling, ACS Chemical Biology 15(1): 217-225.
- Kuo C.L., Kallemeijn W.W., Lelieveld L.T., Mirzaian M., Zoutendijk I., Vardi A., Futerman A.H., Meijer A.H., Spaink H.P., Overkleeft H.S., Aerts J.M.F.G. & Artola Perez de Azanza M.E. (2019), In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity‐based protein profiling, FEBS Journal 286(3): 584-600.
- Aerts J.M.F.G., Artola M.E., Eijk M.C. van, Ferraz M.J. & Boot R.G. (2019), Glycosphingolipids and infection. Potential new therapeutic avenues, Frontiers in Cell and Developmental Biology 7: 324.
- Kuo C.L., Kallemeijn W.W., Lelieveld L.T., Mirzaian M., Zoutendijk I., Vardi A., Futerman A.H., Meijer A.H., Spaink H.P., Overkleeft H.S., Aerts J.M.F.G. & Artola M. (2019), In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling, FEBS Journal 286(3): 584-600.
- Artola Perez de Azanza M.E., Wouters S., Schröder S.P., Boer C. de, Chen Y., Petracca R., Nieuwendijk A.M.C.H. van den, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2019), Direct Stereoselective Aziridination of Cyclohexenols with 3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors, European Journal of Organic Chemistry 2019(6): 1397-1404.
- Kuo C.L., Meel H.M.M. van, Kytidou K., Kallemeijn W.W., Witte M., Overkleeft H.S., Artola Pérez de Azanza M.E. & Aerts J.M.F.G. (2018), Activity-Based Probes for Glycosidases: Profiling and Other Applications. In: Imperiali B. (red.), Chemical Glycobiology Part B. Monitoring Glycans and their Interactions. Methods in Enzymology nr. 598: Elsevier: Monograph Series. 217-235.
- Schröder S.P., Wu L., Artola Perez de Azanza M.E., Hansen T., Offen W.A., Guimaraes da Lomba Ferraz M.J., Li K.-Y., Aerts J.M.F.G., Marel G.A. van der, Codee J.D.C., Davies G.J. & Overkleeft H.S. (2018), Gluco-1H-imidazole: A New Class of Azole-Type beta-Glucosidase Inhibitor, Journal of the American Chemical Society 140(15): 5045-5048.
- Ben Bdira F., Artola Perez de Azana M.E., Overkleeft H.S., Ubbink M. & Aerts J.M.F.G. (2018), Distinguishing the differences in beta-glycosylceramidase folds, dynamics, and actions informs therapeutic uses, Journal of Lipids 59(12): 2262-2276.
- Kytidou K., Beekwilder J., Artola M., Meel E. van, Wilbers R.H.P., Moolenaar G.F., Goosen N., Ferraz M.J., Katzy R., Voskamp P., Florea B.I., Hokke C.H., Overkleeft H.S., Schots A., Bosch D., Pannu N. & Aerts J.M.F.G. (2018), Nicotiana benthamiana α-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease, Journal of Biological Chemistry 293(26): 10042-10058.
- Artola M., Kuo C.L., McMahon S.A., Oehler V., Hansen T., Lienden M.J.C. van der, He X., Elst H. van den, Florea B.I., Kermode A.R., Marel G.A. van der, Gloster T.M., Codée J.D.C., Overkleeft H.S. & Aerts J.M.F.G. (2018), New Irreversible alpha-l-Iduronidase Inhibitors and Activity-Based Probes, Chemistry: a European Journal 24(71): 19081-19088.
- Breen I.Z., Artola Perez de Azanza M.E., Wu L., Beenakker T.J.M., Offen W.A., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2018), Competitive and covalent inhibitors of human lysosomal retaining exoglucosidases. In: Maccarrone M. (red.), eLS: Wiley Online Library.
- Petracca R., Romeo E., Baggelaar M.P., Artola M., Pontis S., Ponzano S., Overkleeft H.S., Stelt M. van der & Piomelli D. (2017), Novel activity-based probes for N-acylethanolamine acid amidase, Chemical Communications 53(86): 11810-11813.
- Artola Perez de Azanza M.E., Wu L., Guimaraes da Lomba Ferraz M.J., Kuo C.L., Raich L., Breen I.Z., Offen W.A., Codee J.D.C., Marel G.A. van der, Rovira C., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2017), 1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor, ACS Central Science 3(7): 784-793.
- Wu L., Jiang J., Jin Y., Kallemeijn W.W., Kuo C.-L., Artola M., Dai W., Elk C. van, Eijk M. van, Marel G.A. van der, Codee J.D.C., Florea B.I., Aerts J.M.F.G., Overkleeft H.S. & Davies G.J. (2017), Activity-based probes for functional interrogation of retaining beta-glucuronidases, Nature Chemical Biology 13(8): 867-873.
- Beenakker T.J.M., Wander D.P.A., Offen W.A., Artola Perez de Azanza M.E., Raich L., Guimaraes da Lomba Ferraz M.J., Li K.Y., Houben J.H.P.M., Rijssel E.R. van, Hansen T., Marel G.A. van der, Codee J.D.C., Aerts J.M.F.G., Rovira C., Davies G.J. & Overkleeft H.S. (2017), Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors, Journal of the American Chemical Society 139(19): 6534-6537.
- Schröder S.P., Sande J.W. van de, Kallemeijn W.W., Kuo C.L., Artola Perez de Azanza M.E., Rooden E.J. van, Jiang J., Beenakker T.J.M., Florea B.I., Offen W.A., Davies G.J., Minnaard A.J., Aerts J.M.F.G., Codee J.D.C., Marel G.A. van der & Overkleeft H.S. (2017), Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines, Chemical Communications 53(93): 12528-12531.
- Parker C.G., Kuttruff C.A., Galmozzi A., Jorgensen L., Yeh C.-H., Hermanson D.J., Wang Y., Artola M., McKerrall S.J., Josyln C.M., Norremark B., Dunstl G., Felding J., Saez E., Baran P.S. & Cravatt B.F. (2017), Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs, ACS Central Science 3(12): 1276-1285.
- Artola M., Ruiz-Avila L.B., Ramirez-Aportela E., Fernando Martinez R., Araujo-Bazan L., Vazquez-Villa H., Martin-Fontecha M., Oliva M.A., Martin-Galiano A.J., Chacon P., Lopez-Rodriguez M.L., Andreu J.M. & Huecas S. (2017), The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors, Chemical Science 8(2): 1525-1534.
- Jiang J., Artola Perez de Azanza M.E., Beenakker T.J.M., Schröder S.P., Petracca R., Boer C. de, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2016), The synthesis of cyclophellitol-aziridine and its configurational and functional isomers, European Journal of Organic Chemistry 2016(22): 3671-3678.
- Schroder S., Petracca R., Minnee H., Artola M., Aerts J.M.F.G., Codée J.D.C., Marel G.A. van der & Overkleeft H.S. (2016), A Divergent Synthesis of L-arabino- and D-xylo-configured Cyclophellitol Epoxides and Aziridines, European Journal of Organic Chemistry : .
- Artola Perez de Azanza M., Ruiz-Avila L.B., Vergonos A., Huecas S., Araujo-Bazan L., Martin-Fontecha M., Vazquez-Villa H., Turrado C., Ramirez-Aportela E., Hoegl A., Nodwell M., Barasoain I., Chacon P., Sieber S.A., Andreu J.M. & Lopez-Rodriguez M.L. (2015), Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action, ACS Chemical Biology 10(3): 834-843.
- Bartolome-Nebreda J.M., Alonso de Diego S.A., Artola M., Delgado F., Delgado O., Luz Martin-Martin M., Martinez-Viturro C.M., Ángel Pena M., Min Tong H., Gool M. van, Manuel Alonso J., Fontana A., Macdonald G.J., Megens A., Langlois X., Somers M., Vanhoof G. & Conde-Ceide S. (2015), Identification of a Novel Orally Bioavailable Phosphodiesterase 10A (PDE10A) Inhibitor with Efficacy in Animal Models of Schizophrenia, Journal of Medicinal Chemistry 58(2): 978-993.
- Perez-Gomez E., Andradas C., Blasco-Benito S., Caffarel M.M., Garcia-Taboada E., Villa-Morales M., Moreno E., Hamann S., Martin-Villar E., Flores J.M., Wenners A., Alkatout I., Klapper W., Roecken C., Bronsert P., Stickeler E., Staebler A., Bauer M., Arnold N., Soriano J., Perez-Martinez M., Megias D., Moreno-Bueno G., Ortega-Gutierrez S., Artola M., Vazquez-Villa H., Quintanilla M., Fernandez-Piqueras J., Canela E.I., McCormick P.J., Guzman M. & Sanchez C. (2015), Role of Cannabinoid Receptor CB2 in HER2 Pro-oncogenic Signaling in Breast Cancer, Journal of the National Cancer Institute 107(6): djv077.
- Ruiz-Ayila L.B., Huecas S., Artola M., Vergonos A., Ramirez-Aportela E., Cercenado E., Barasoain I., Vazquez-Villa H., Martin-Fontecha M., Chacon P., Lopez-Rodriguez M.L. & Andreu J.M. (2013), Synthetic Inhibitors of Bacterial Cell Division Targeting the GTP-Binding Site of FtsZ, ACS Chemical Biology 8(9): 2072-2083.
- Turrado C., Puig T., Garcia-Carceles J., Artola Perez de Azanza M., Benhamu B., Ortega-Gutierrez S., Relat J., Oliveras G., Blancafort A., Haro D., Marrero P.F., Colomer R. & Lopez-Rodriguez M.L. (2012), New Synthetic Inhibitors of Fatty Acid Synthase with Anticancer Activity, Journal of Medicinal Chemistry 55(11): 5013-5023.