Marina Gorostiola González
Promovendus / gast
- Naam
- M. Gorostiola González MSc
- Telefoon
- +31 71 527 2727
- m.gorostiola.gonzalez@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0003-1568-0881
Voor meer informatie zie de Engelse profielpagina
Promovendus / gast
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal Chemistry
- Veggel L. van, Mocking T.A.M., Sijben H.J., Liu R., Gorostiola González M., Dilweg M.A., Royakkers J., Li A., Kumar V., Dong Y.Y., Bullock A., Sauer D.B., Diliën H., Westen G.J.P. van, Schreiber R., Heitman L.H. & Vanmierlo T. (2024), Still in search for an EAAT activator: GT949 does not activate EAAT2, nor EAAT3 in impedance and radioligand uptake assays, ACS Chemical Neuroscience 15(7): 1424-1431.
- Gorostiola González M.: Rakers P.R.J., Jespers W., IJzerman A.P. & Heitman L.H. Westen G.J.P. van (2024), Computational characterization of membrane proteins as anticancer targets: current challenges and opportunities, International Journal of Molecular Sciences 25(7): 3698.
- Mullowney M.W., Duncan K.R., Elsayed S.S., Garg N., Hooft J.J.J. van der, Martin N.I., Meijer D., Terlouw B.R., Biermann F., Blin K., Durairaj J., Gorostiola González M., Helfrich E.J.N., Huber F., Leopold-Messer S., Rajan K., Rond T. de, Santen J.A. van, Sorokina M., Balunas M.J., Beniddir M.A., Bergeijk D.A. van, Carroll L.M., Clark C.M., Clevert D.A., Dejong C.A., Du C., Ferrinho S., Grisoni F., Hofstetter A., Jespers W., Kalinina O.V., Kautsar S.A., Kim H., Leao T.F., Masschelein J., Rees E.R., Reher R., Reker D., Schwaller P., Segler M., Skinnider M.A., Walker A.S., Willighagen E.L., Zdrazil B., Ziemert N., Goss R.J.M., Guyomard P., Volkamer A., Gerwick W.H., Kim H.U., Müller R., Wezel G.P. van, Westen G.J.P. van, Hirsch A.K.H., Linington R.G., Robinson S.L. & Medema M.H. (2023), Artificial intelligence for natural product drug discovery, Nature Reviews Drug Discovery 22: 895-916.
- Gorostiola Gonzalez M., Sijben H.J., Dall' Acqua L., Liu R., IJzerman A.P., Heitman L.H. & Westen G.J.P. van (2023), Molecular insights into disease-associated glutamate transporter (EAAT1 / SLC1A3) variants using in silico and in vitro approaches, Frontiers in Molecular Biosciences 10: 1286673.
- Gorostiola González M., Broek R.L. van den, Braun T.G.M., Chatzopoulou Chatzi A., Jespers W., IJzerman A.P., Heitman L.H. & Westen G.J.P. van (2023), 3DDPDs: describing protein dynamics for proteochemometric bioactivity prediction. A case for (mutant) G protein-coupled receptors, Journal of Cheminformatics 15(1): 74.
- Hollander L.S. den, Béquignon O.J.M., Wang X., Wezel K. van, Broekhuis J.D., Gorostiola Gonzalez M., Visser K.E. de, IJzerman A.P., Westen G.J.P. van & Heitman L.H. (2023), Corrigendum to "Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism" [Biochem. Pharmacol. 208 (2023) 115399], Biochemical Pharmacology 209: 115540 (115450).
- Feng C.L., Wang X., Jespers W., Liu R., Zamarbide Losada S.D., Gorostiola Gonzalez M., Westen G.J.P. van, Danen E.H.J. & Heitman L.H. (2022), Cancer-associated mutations of the adenosine A2A receptor have diverse influences on ligand binding and receptor functions, Molecules 27(15): 4676.
- Gorostiola Gonzalez M., Janssen A.P.A., IJzerman A.P., Heitman L.H. & Westen G.J.P. van (2022), Oncological drug discovery: AI meets structure-based computational research, Drug Discovery Today 27(6): 1661-1670.
- Hollander L.S. den, Béquignon O.J.M., Wang X., Wezel K. van, Broekhuis J., Gorostiola González M., Visser K.E. de, IJzerman A.P., Westen G.J.P. van & Heitman L.H. (2022), Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism, Biochemical Pharmacology 208: 115399.
- Bongers B.J., Gorostiola González M., Wang X., Vlijmen H. van, Jespers W., Gutiérrez-de-Terán H., Ye K., IJzerman A.P., Heitman L.H. & Westen G.J.P. van (2022), Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors, Scientific Reports 12(1): 21534.
- Kovacikova K., Gorostiola González M., Jones R., Requera J., Gigante A., Pérez-Pérez M.J., Pürstinger G., Moesslacher J., Langer T., Jeong L.S., Delang L., Neyts J., Snijder E.J., Westen G.J.P. van & Hemert M.J. van (2021), Structural insights into the mechanisms of action of functionally distinct classes of chikungunya virus nonstructural protein 1 inhibitors, Antimicrobial Agents and Chemotherapy 65(7): e02566-20.
- Burggraaff L. Lenselink E.B. Jespers W. Engelen J. van Bongers B.J. Gorostiola Gonzalez M. Liu R. Hoos H.H. Vlijmen H. van IJzerman A.P. Westen G.J.P. van (2020), Successive statistical and structure-based modeling to identify chemically novel kinase inhibitors, Journal of Chemical Information and Modeling 60(9): 4283-4295.