Marie Depuydt
Onderzoeker
- Naam
- Dr. M.A.C. Depuydt
- Telefoon
- +31 71 527 6213
- m.a.c.depuydt@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-7174-1952
Nieuws
-
Marie Depuydt wint Van Wersch Springplankprijs -
Ontsteking onder de loep: nieuwe aanknopingspunten voor de behandeling van slagaderverkalking -
Slagaderverkalking en medicijnontdekking: deze twee jonge onderzoekers wonnen een Krijn Rietveld Award voor innovatief onderzoek -
Slagaderverkalking lijkt op een auto-immuunziekte. Marie Depuydt promoveerde er cum laude op -
Waarom slagaderverkalking een auto-immuunziekte lijkt
Onderzoeker
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Biopharmaceutics
- Depuydt M.A.C. (28 maart 2024), Single-cell immune profiling of atherosclerosis: from omics to therapeutics (Dissertatie. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University). Promotor(en): Kuiper J., Slütter B. & Bot I.
- Mulholland M., Depuydt M.A.C., Jakobsson G., Ljungcrantz I., Grentzmann A., To F., Bengtsson E., Jaensson Gyllenbäck E., Grönberg C., Rattik S., Liberg D., Schiopu A., Björkbacka H., Kuiper J., Bot I., Slütter B.A. & Engelbertsen D. (2024), Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation, Cardiovascular Research 120(6): 581-595.
- Jong M.J.M. de, Schaftenaar F.H., Depuydt M.A.C., Lozano Vigario F., Janssen G.M.C., Peeters J.A.H.M., Goncalves L., Wezel A., Smeets H.J., Kuiper J., Bot I., Veelen P. van & Slütter B.A. (2024), Virus-associated CD8+T-cells are not activated through antigen-mediated interaction inside atherosclerotic lesions, Arteriosclerosis, Thrombosis, and Vascular Biology 44: 1302-1314.
- Schaftenaar F.H., Dam A.D. van, Bruin G. de, Depuydt M.A.C., Mol J., Amersfoort J., Douna H., Meijer M., Kröner M.J., Santbrink P.J. van, Bernabé Kleijn M.N.A., Puijvelde G.H.M. van, Florea B.I., Slütter B., Foks A.C., Bot I., Rensen P.C.N. & Kuiper J. (2024), Immunoproteasomal inhibition with ONX-0914 attenuates atherosclerosis and reduces white adipose tissue mass and metabolic syndrome in mice, Arteriosclerosis, Thrombosis, and Vascular Biology 44(6): 1346–1364.
- Jong M.J.M. de, Depuydt M.A.C., Schaftenaar F.H., Liu K., Maters D., Wezel A., Smeets H.J., Kuiper J., Bot I., Gisbergen K. van & Slütter B.A. (2024), Resident memory T cells in the atherosclerotic lesion associate with reduced macrophage content and increased lesion stability, Arteriosclerosis, Thrombosis, and Vascular Biology 44(6): 1318–1329.
- Smit V., Mol J. de, Bernabé Kleijn M.N.A.B., Depuydt M.A.C., Winther M.P.J. de Bot I., Kuiper J. & Foks A.C. (2024), Sexual dimorphism in atherosclerotic plaques of aged Ldlr-/- mice, Immunity and Ageing 21(1): 27.
- Depuydt M.A.C., Smit V., Schaftenaar F.H., Hemme E., Delfos L., Vlaswinkel F.D., Simpson C., Kovanen P.T., Slütter B.A., Kuiper J., Bot I. & Foks A.C. (2024), Aging promotes mast cell activation and antigen presenting capacity in atherosclerosis, Cardiovascular Research 120(Supplement 1): cvae088.201.
- Prange K., Bel-Bordes G., Depuydt M.A.C., Kempkes R.W.M., Jong M.D.M. de, Mol B.M., Slütter B., Bot I., Neele A.E., Kleijn D.P.V. de, Borst G.J. de, Kuiper J., Pasterkamp. G., Mokry M. & Winther M.P.J. de (2024), Human atherosclerotic plaque macrophages associate with clinical presentation and follow diverse lineage differentiation routes, Cardiovascular Research 120(Supplement 1): cvae088.168.
- Hemme E., Depuydt M.A.C., Santbrink P.J. van, Wezel A., Smeets H.J., Foks A.C., Kuiper J. & Bot I. (2024), Leukemia inhibitory factor receptor inhibition by EC359 reduces atherosclerotic stenosis grade in Ldlr-/- mice, European Journal of Pharmacology 985: 177121.
- Panhuis W. in het, Schönke M., Modder M., Tom H.E., Lalai R.A., Pronk A.C.M., Streefland T.C.M., Kerkhof L.W.M. van, Dollé M.E.T., Depuydt M.A.C., Bot I., Vos W.G., Bosmans L.A., Os B.W. van, Lutgens E., Rensen P.C.N. & Kooijman S. (2023), Time-restricted feeding attenuates hypercholesterolaemia and atherosclerosis development during circadian disturbance in APOE∗3-Leiden.CETP mice, EBioMedicine 93: 104680.
- Smit V., Mol J. de, Schaftenaar F.H., Depuydt M.A.C., Postel R.J., Smeets D.: Verheijen F.W.M., Bogers L., Duijn J. van, Verwilligen R.A.F., Grievink H.W., Bernabé Kleijn M.N.A., Ingen E. van, Jong M.J.M. de, Goncalves L.: Peeters J.A.H.M., Smeets H.J., Wezel A., Polansky J.K., Winther M.P.J. de, Binder C.J., Tsiantoulas D., Bot I., Kuiper J. & Foks A.C. (2023), Single-cell profiling reveals age-associated immunity in atherosclerosis, Cardiovascular Research 119(15): 2508-2521.
- Lozano Vigario F., Simo Vesperinas I., Depuydt M.A.C., Bot I., Veelen P. van, Bouwstra J.A., Kros A. & Slutter B. (2023), Immunopeptidomic analysis of human atherosclerosis identifies novel ApoB100-derived antigenic drivers of atherosclerosis, Atherosclerosis 379: S8-S9.
- Hemme E., Depuydt M.A.C., Delfos L., Kuiper J. & Bot I. (2023), Leukemia inhibitory factor receptor inhibition in atherosclerosis, Atherosclerosis 379: S36.
- Delfos L., Depuydt M.A.C., Foks A.C., Bernabe Kleijn M.N.A., Kuiper J., Chemaly M., Peace A., McGilligan V. & Bot I. (2023), NLRP3 inflammasome inhibition by the novel bispecific antibody inflamab inhibits atherosclerosis in apolipoprotein E-deficient mice, Atherosclerosis 379(Supplement 1): S2.
- Depuydt M.A.C., Schaftenaar F.H., Prange H.H.M., Boltjes A., Hemme E., Delfos L., Mol J. de, Jong M.J.M. de, Bernabé Kleijn M.N.A., Peeters J.A.H.M., Goncalves L., Wezel A., Smeets H.J., Borst G.J. de, Foks A.C., Pasterkamp G., Winther M.P.J. de, Kuiper J., Bot I. & Slütter B. (2023), Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells, Nature Cardiovascular Research 2: 112-125.
- Hemme E.: Biskop D., Depuydt M.A.C., Smit V., Delfos L., Bernabé Kleijn M.N.A., Foks A.C., Kuiper J. & Bot I. (2023), Bruton's Tyrosine Kinase inhibition by Acalabrutinib does not affect early or advanced atherosclerotic plaque size and morphology in Ldlr-/- mice, Vascular Pharmacology 150: 107172.
- Depuydt M.A.C., Smit V., Lozano Vigario F., Bernabé Kleijn M.N.A., Vries M.R. de, Quax P.H.A., Wezel A., Smeets H.J., Kuiper J., Foks A.C., Bot I. & Slütter B.A. (2022), Granzyme B+CD4+T cells associate with an unstable plaque phenotype in advanced human atherosclerosis, Cardiovascular Research 118(Supplement_1): cvac066.229.
- Depuydt M.A.C., Vlaswinkel F.D., Hemme E., Delfos L., Bernabe Kleijn M.N.A., Santbrink P.J. van, Foks A.C., Slütter B., Kuiper J. & Bot I. (2022), Blockade of the BLT1-LTB4 axis does not affect mast cell migration towards advanced atherosclerotic lesions in LDLr-/- mice, Scientific Reports 12(1): 18362.
- Postel R.J., Smit V., De Mol J., Bernabé Kleijn M.N.A., De Jong M.J.M., Delfos L., Hemme E., Depuydt M.A.C., Bot I., Kuiper J. & Foks A.C. (2022), IL-21R blockade reduces atherosclerosis development in LDLR-/- mice, Atherosclerosis 355: 23.
- Slenders L., Landsmeer L.P.L., Cui K., Depuydt M.A.C., Verwer M., Mekke J., Timmerman N., Dungen N.A.M. van den, Kuiper J., Winther M.P.J. de Prange K.H.M., Ma W.F., Miller C.L., Aherrahrou R., Civelek M., Borst G.J. de, Kleijn D.P.V. de, Asselbergs F.W., Ruijter H.M. den, Boltjes A, Pasterkamp G. & Laan S.W. van den Mokry M. (2021), Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis, European Heart Journal Open 2(1): oeab043.
- Douna H., Amersfoort J., Schaftenaar F.H., Kröner M.J., Kiss M.B., Slütter B.A., Depuydt M.A.C., Bernabé Kleijn M.N.A., Wezel A., Smeets H., Yagita H., Binder C.J., Bot I., Puijvelde G.H.M. van, Kuiper J. & Foks A.C. (2020), BTLA stimulation protects against atherosclerosis by regulating follicular B cells, Cardiovascular Research 116(2): 295-305.
- Depuydt M.A.C., Prange K.H.M., Slenders L., Örd T., Elbersen D., Boltjes A., Jager S.C.A. de, Asselbergs F.W., Borst G.J. de, Aavik E., Lönnberg T., Lutgens E., Glass C.K., Ruijter H.M. den, Kaikkonen M.U., Bot I., Slütter B., Laan S.W. van der, Yla-Herttuala S., Mokry M., Kuiper J., Winther M.P.J. de & Pasterkamp G. (2020), Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics, Circulation Research 127(11): 1437-1455.
- Sluis R.J. van der, Depuydt M.A.C., Eck M. van & Hoekstra M. (2020), VLDL/LDL serves as the primary source of cholesterol in the adrenal glucocorticoid response to food deprivation, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865(7): 158682.
- Kritikou E., Depuydt M.A.C., Vries M.R. de, Mulder K.E., Govaert A.M., Smit M.D., Duijn J. van, Foks A.C., Wezel A., Smeets H.J., Slütter B., Quax P.H.A., Kuiper J. & Bot I. (2019), Flow Cytometry-Based Characterization of Mast Cells in Human Atherosclerosis, Cells 8(4): 334.
- Sluis R.J. van der, Depuydt M.A.C., Verwilligen R.A.F., Hoekstra M. & Eck M. van (2019), Elimination of adrenocortical apolipoprotein E production does not impact glucocorticoid output in wild-type mice, Molecular and Cellular Endocrinology 490: 21-27.
- Duijn J. van, Elsas M. van, Benne N., Depuydt M.A.C., Wezel A., Smeets H., Bot I., Jiskoot W., Kuiper J. & Slütter B.A. (2019), CD39 identifies a microenvironment-specific anti-inflammatory CD8+ T-cell population in atherosclerotic lesions, Atherosclerosis 285: 71-78.
- Douna H., Amersfoort J., Schaftenaar F.H., Kröner M.J., Kiss M.B., Slütter B., Depuydt M.A.C., Kleijn M.N.A.B., Wezel A., Smeets H., Yagita H., Binder C.J., Bot I., Puijvelde G.H.M. van, Kuiper J. & Foks A.C. (2019), B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells, Cardiovascular Research 116(2): 295-305.
- Duijn J. van, Elsas M. van, Benne N., Depuydt M., Wezel A., Smeets H., Bot I., Jiskoot W., Kuiper J. & Slutter B. (2019), Continuous Tcr signaling in the atherosclerotic environment induces immunomodulatory Cd8+ T-cells expressing Cd39, Atherosclerosis 287: e17-e18.
- Laan S.W. van der, Slenders L., Depuydt M., Prange K., Granneman L., Elbersen D., Boltjes A., Jager S. de, Slutter B., Bot I., Winther M., Kuiper J., Mokry M., Asselbergs F. & Pasterkamp G. (2019), Mapping genes to cardiovascular susceptibility loci at a single-cell resolution, Atherosclerosis 287: E21-E21.
- Depuydt M., Prange K.H.M., Slenders L., Elbersen D., Boltjes A., De Jager S.C.A., Slutter B.A., Bot I., Laan S.W. van der, Mokry M., Pasterkamp G., Winther M.P.J. de & Kuiper J. (2019), Microanatomy of advanced human atherosclerotic plaques through single-cell transcriptomics, Atherosclerosis 287: E5-E5.
- Mokry M., Depuydt M.A.C., Prange K.H.M., Slenders L., Elbersen D., Granneman L.E.C., Jager S.C.A. de, Slutter B.A., Bot I., Winther M.P.J. de, Kuiper J., Asselbergs F.W., Laan S.W. van der & Pasterkamp G. (2019), Single cell Rna-sequencing identifies numerous cell sub-types and suggests lineage plasticity in human atherosclerotic plaques, Atherosclerosis 287: E96-E97.
- Slütter B.A., Depuydt M.A.C., Duijn J. van, Bot I., Wezel A., Koppejan H., Toes R. & Kuiper J. (2018), Masscytometry identifies CD8 T-cell diversity in human atherosclerotic lesions, Atherosclerosis 275: e8.