Manfred Wuhrer
Hoogleraar Proteomics and Glycomics
- Naam
- Prof.dr. M. Wuhrer
- Telefoon
- +31 71 526 9111
- m.wuhrer@lumc.nl
- ORCID iD
- 0000-0002-0814-4995
Manfred Wuhrer is hoogleraar proteomics en glycomics en hoofd van het Center for Proteomics and Metabolomics van het Leids Universitair Medisch Centrum (LUMC). Daarnaast is hij voorzitter van de Nederlandse Vereniging voor Massa Spectrometrie (NVMS).
Meer informatie over Manfred Wuhrer
Manfred Wuhrer is hoogleraar proteomics en glycomics en hoofd van het Center for Proteomics and Metabolomics van het Leids Universitair Medisch Centrum (LUMC). Daarnaast is hij voorzitter van de Nederlandse Vereniging voor Massa Spectrometrie (NVMS).
Wetenschappelijke carrière
Manfred Wuhrer heeft biochemie gestudeerd aan de Universiteit van Regensburg, Duitsland. Hij promoveerde aan de Universiteit van Giessen in 1999 over de characterisatie van stadium-specifiek geexprimeerde glycolipiden van de humane parasiet Schistosoma mansoni. In 2003 kwam hij naar het LUMC en begon met het opzetten van een onderzoekslijn over de massa spectrometrische analyse van glycosylering.
Hij werd in 2013 benoemd als hoogleraar Analytics of Biomolecular Interactions aan de Vrije Universiteit Amsterdam. Sinds 2015 is hij hoogleraar Proteomics and Glycomics en hoofd van het Center for Proteomics en Metabolomics van het LUMC. De titel van zijn oratie is 'Ziekten op de weegschaal'.
Hoogleraar Proteomics and Glycomics
- Faculteit Geneeskunde
- Divisie 4
- Klinische Farmacie en Toxicologie
- Claushuis, B.; Cordfunke, R.A.; Ru, A.H. de; Angeren, J. van; Baumann, U.; Veelen, P.A. van; Wuhrer, M.; Corver, J.; Drijfhout, J.W. & Hensbergen, P.J. (2024), Non-prime- and prime-side profiling of Pro-Pro endopeptidase specificity using synthetic combinatorial peptide libraries and mass spectrometry, The FEBS Journal.
- Moran, A.B.; Elgood-Hunt, G.; Burgt, Y.E.M. van der; Wuhrer, M.; Mesker, W.E.; Tollenaar, R.A.E.M.; Spencer, D.I.R. & Lageveen-Kammeijer, G.S.M. (2023), Serum N-glycosylation RPLC-FD-MS assay to assess colorectal cancer surgical interventions, Biomolecules 13(6).
- Xu, R.Y.; Wang, X.X.; Safi, S.; Braunegger, N.; Ederveen, A.H.; Rottmann, M.; Wittbrodt, J.; Wuhrer, M.; Wesslowski, J. & Davidson, G. (2023), N-glycosylation of LRP6 by B3GnT2 promotes Wnt/βcatenin signalling, Cells 12(6).
- Mayboroda, O.A.; Lageveen-Kammeijer, G.S.M.; Wuhrer, M. & Dolhain, R.J.E.M. (2023), An integrated glycosylation signature of rheumatoid arthritis, Biomolecules 13(7).
- Blöchl, C.; Gstöttner, C.; Sénard, T.; Stork, E.M.; Scherer, H.U.; Toes, R.E.M.; Wuhrer, M. & Domínguez-Vega, E. (2023), A robust nanoscale RP HPLC-MS approach for sensitive Fc proteoform profiling of IgG allotypes, Analytica Chimica Acta 1279.
- Marco, F. di; Blümel, G.; Blöchl, C.; Wuhrer, M. & Huber, C.G. (2023), A semi-automated hybrid HPLC-MS approach for in-depth characterization of intact non-covalent heterodimer glycoforms of gonadotropin biopharmaceuticals, Analytica Chimica Acta 1274.
- Graaf, E.L. de; Larsen, M.D.; Bolt, N. van der; Visser, R.; Verhagen, O.J.H.M.; Ederveen, A.L.H.; Koeleman, C.A.M.; Schoot, C.E. van der; Wuhrer, M. & Vidarsson, G. (2023), Assessment of IgG-Fc glycosylation from individual RhD-specific B cell clones reveals regulation at clonal rather than clonotypic level, Immunology.
- Szittner, Z.; Bentlage, A.E.H.; Temming, A.R.; Schmidt, D.E.; Visser, R.; Lissenberg-Thunnissen, S.; Mok, J.Y.; Esch, W.J.E. van; Sonneveld, M.E.; Graaf, E.L. de; Wuhrer, M.; Porcelijn, L.; Haas, M. de; Schoot, C.E. van der & Vidarsson, G. (2023), Cellular surface plasmon resonance-based detection of anti-HPA-1a antibody glycosylation in fetal and neonatal alloimmune thrombocytopenia, Frontiers in Immunology 14.
- Kaplonek, P.; Cizmeci, D.; Kwatra, G.; Izu, A.; Lee, J.S.L.; Bertera, H.L.; Fischinger, S.; Mann, C.; Amanat, F.; Wang, W.J.; Koen, A.L.; Fairlie, L.; Cutland, C.L.; Ahmed, K.; Dheda, K.; Barnabas, S.L.; Bhorat, Q.E.; Briner, C.; Krammer, F.; Saphire, E.O.; Gilbert, S.C.; Lambe, T.; Pollard, A.J.; Nunes, M.; Wuhrer, M.; Lauffenburger, D.A.; Madhi, S.A. & Alter, G. (2023), ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19, Nature Immunology 24(7): 1161-+.
- Svecla, M.; Nour, J.; Bladergroen, M.; Nicolardi, S.; Wuhrer, M.; Falck, D. & Norata, G. (2023), CIRCULATING GLYCOME AND PROTEOME SIGNATURE ON ASGR1 AND MRC1 DEFICIENT MICE, Atherosclerosis 379.
- Coillie, J. van; Pongracz, T.; Sustic, T.; Wang, W.J.; Nouta, J.; Gars, M. le; Keijzer, S.; Linty, F.; Cristianawati, O.; Keijser, J.B.D.; Visser, R.; Vught, L.A. van; Slim, M.A.; Mourik, N. van; Smit, M.J.; Sander, A.; Schmidt, D.E.; Steenhuis, M.; Rispens, T.; Nielsen, M.A.; Mordmüller, B.G.; Vlaar, A.P.J.; Schoot, C.E. van der; Roozendaal, R.; Wuhrer, M.; Vidarsson, G.; UMC COVID-19 S3 HCW Study Grp; Fatebenefratelli-Sacco Infect; Radboud Univ Med Ctr RUMC & COUGH1 Study Grp (2023), Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines, iScience 26(9).
- Romer, T.B.; Khoder-Agha, F.; Aasted, M.K.M.; Haan, N. de; Horn, S.; Dylander, A.; Zhang, T.; Pallesen, E.M.H.; Dabelsteen, S.; Wuhrer, M.; Hogsbro, C.F.; Thomsen, E.A.; Mikkelsen, J.G. & Wandall, H.H. (2023), CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation, Glycobiology 33(9).
- Schaick, G. van; Wuhrer, M. & Domínguez-Vega, E. (2023), Dopant-enriched nitrogen gas to boost ionization of glycoproteins analyzed with native liquid chromatography coupled to nano-electrospray ionization, Analytica Chimica Acta 1265.
- Schaick, G. van; Pot, S.; Schouten, O.; Hartog, J. den; Akeroyd, M.; Hoeven, R.V.; Bijleveld, W.; Abello, N.; Wuhrer, M.; Olsthoorn, M. & Dominguez-Vega, E. (2023), Evaluating the effect of glycation on lipase activity using boronate affinity chromatography and mass spectrometry, Food Chemistry 421.
- Wang, W.; Zhang, T.; Nouta, J.; Veelen, P.A. van; Haan, N. de; Reijke, T.M. de; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2023), Human prostate-specific antigen carries N-glycans with ketodeoxynononic acid, Engineering 26: 119-131.
- Memarian, E.; Heijmans, R.; Slieker, R.C.; Sierra, A.; Gornik, O.; Beulens, J.W.J.; Hanic, M.; Elders, P.; Pascual, J.; Sijbrands, E.; Lauc, G.; Dotz, V.; Barrios, C.; Hart, L.M. 't; Wuhrer, M. & Hoek, M. van (2023), IgG N-glycans are associated with prevalent and incident complications of type 2 diabetes, Diabetes/Metabolism Research and Reviews 39(7).
- Clerc, F.; Reiding, K.R.; Haan, N. de; Koeleman, C.A.M.; Ederveen, A.L.H.; Manetti, N.; Dotz, V.; Annese, V.; Wuhrer, M. & IBD-BIOM Consortium (2023), Immunoglobulin A glycosylation differs between Crohn's disease and ulcerative colitis, Journal of Proteome Research 22(10): 3213-3224.
- Tol, B.D.M. van; Doodewaerd, B.R. van; Lageveen-Kammeijer, G.S.M.; Jansen, B.C.; Talavera Ormeño, C.M.P.; Hekking, P.J.M.; Sapmaz, A.; Kim, R.Q.; Moutsiopoulou, A.; Komander, D.; Wuhrer, M.; Heden van Noort, G.J. van der; Ovaa, H. & Geurink, P.P. (2023), Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes, Nature Communications 14(1).
- Madunic, K.; Luijkx, Y.M.C.A.; Mayboroda, O.A.; Janssen, G.M.C.; Veelen, P.A.V.; Strijbis, K.; Wennekes, T.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2023), O-glycomic and proteomic signatures of spontaneous and butyrate-stimulated colorectal cancer cell line differentiation, Molecular & Cellular Proteomics 22(3).
- Wang, D.; Madunic, K.; Zhang, T.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2023), Profound diversity of the N-glycome from microdissected regions of colorectal cancer, stroma, and normal colon mucosa, Engineering 26: 32-43.
- Moran, A.B.; Domínguez-Vega, E.; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2023), Software-assisted data processing workflow for intact glycoprotein mass spectrometry, Journal of Proteome Research 22(4): 1367-1376.
- Wojcik, I.; Wuhrer, M.; Heeringa, P.; Stegeman, C.A.; Rutgers, A. & Falck, D. (2023), Specific IgG glycosylation differences precede relapse in PR3-ANCA associated vasculitis patients with and without ANCA rise, Frontiers in Immunology 14.
- Porcino, G.N.; Bladergroen, M.R.; Dotz, V.; Nicolardi, S.; Memarian, E.; Gardinassi, L.G.; Costa, C.H.N.; Almeida, R.P.D.; Santos, I.K.F.D. & Wuhrer, M. (2023), Total serum N-glycans mark visceral leishmaniasis in human infections with Leishmania infantum, iScience 26(7).
- Boelaars, K.; Goossens-Kruijssen, L.; Wang, D.; Winde, C.M. de; Rodriguez, E.; Lindijer, D.; Springer, B.; Avila, I.V.; Haas, A. de; Wehry, L.; Boon, L.; Mebius, R.E.; Montfoort, N. van; Wuhrer, M.; Haan, J.M.M. den; Vliet, S.J. van & Kooyk, Y. van (2023), Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancer, Journal for ImmunoTherapy of Cancer 11(11).
- Blochl, C.; Wang, D.; Mayboroda, O.A.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2023), Transcriptionally imprinted glycomic signatures of acute myeloid leukemia, Cell & Bioscience 13(1).
- Guo, R.R.; Lageveen-Kammeijer, G.S.M.; Wang, W.J.; Dalebout, H.; Zhang, W.A.; Wuhrer, M.; Liu, L.; Heijs, B. & Voglmeir, J. (2023), Analysis of Immunogenic Galactose-alpha-1,3-galactose-Containing N-Glycans in beef, mutton, and pork tenderloin by Combining Matrix-Assisted Laser Desorption/Ionization-mass spectroscopy and capillary electrophoresis hyphenated with mass spectrometry via electrospray ionization, Journal of Agricultural and Food Chemistry 71(9).
- Oskam, N.; Damelang, T.; Streutker, M.; Heer, P.; Nouta, J.; Koeleman, C.; Coillie, J. van; Wuhrer, M.; Vidarsson, G. & Rispens, T. (2023), Factors affecting IgG4-mediated complement activation, Frontiers in Immunology 14.
- Volkov, M.; Brinkhaus, M.; Schie, K.A. van; Bondt, A.; Kissel, T.; Kooi, E.J. van der; Bentlage, A.E.H.; Koeleman, C.A.M.; Taeye, S.W. de; Derksen, N.I.; Dolhain, R.J.E.M.; Braig-Scherer, U.; Huizinga, T.W.J.; Wuhrer, M.; Toes, R.E.M.; Vidarsson, G. & Woude, D. van der (2023), IgG Fab glycans hinder FcRn-mediated placental transport, The Journal of Immunology 210(2): 158-167.
- Wang, D.; Kuzyk, V.; Madunic, K.; Zhang, T.; Mayboroda, O.A.; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2023), In-depth analysis of the N-glycome of colorectal cancer cell lines, International Journal of Molecular Sciences 24(5).
- Buhre, J.S.; Pongracz, T.; Kunsting, I.; Lixenfeld, A.S.; Wang, W.J.; Nouta, J.; Lehrian, S.; Schmelter, F.; Lunding, H.B.; Duhring, L.; Kern, C.; Petry, J.; Martin, E.L.; Foh, B.; Steinhaus, M.; Kopylow, V. von; Sina, C.; Graf, T.; Rahmoller, J.; Wuhrer, M. & Ehlers, M. (2023), mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine, Frontiers in Immunology 13.
- Schaick, G. van; Dominguez-Vega, E.; Castel, J.; Wuhrer, M.; Hernandez-Alba, O. & Cianferani, S. (2023), Online collision-induced unfolding of therapeutic monoclonal antibody glyco-variants through direct hyphenation of cation exchange chromatography with native ion mobility-mass spectrometry, Analytical Chemistry 95(8).
- Spanov, B.; Baartmans, B.; Olaleye, O.; Nicolardi, S.; Govorukhina, N.; Wuhrer, M.; Merbel, N.C. van de & Bischoff, R. (2023), Revealing charge heterogeneity of stressed trastuzumab at the subunit level, Analytical and Bioanalytical Chemistry 415(8): 1505-1513.
- Coillie, J. van; Pongracz, T.; Rahmoller, J.; Chen, H.J.; Geyer, C.E.; Vught, L.A. van; Buhre, J.S.; Sustic, T.; Osch, T.L. van; Steenhuis, M.; Hoepel, W.; Wang, W.J.; Lixenfeld, A.S.; Nouta, J.; Keijzer, S.; Linty, F.; Visser, R.; Larsen, M.D.; Martin, E.L.; Kunsting, I.; Lehrian, S.; Kopylow, V. von; Kern, C.; Lunding, H.B.; Winther, M. de; Mourik, N. van; Rispens, T.; Graf, T.; Slim, M.A.; Minnaar, R.P.; Bomers, M.K.; Sikkens, J.J.; Vlaar, A.P.J.; Schoot, C.E. van der; Dunnen, J. den; Wuhrer, M.; Ehlers, M.; Vidarsson, G.; Fatebenefratelli-Sacco Infect Dis & UMC COVID-19 S HCW Study Grp (2023), The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees, EBioMedicine 87.
- Holborough-Kerkvliet, M.D.; Mucignato, G.; Moons, S.J.; Psomiadou, V.; Konada, R.S.R.; Pedowitz, N.J.; Pratt, M.R.; Kissel, T.; Koeleman, C.A.M.; Tjokrodirijo, R.T.N.; Veelen, P.A. van; Huizinga, T.; Schie, K.A.J. van; Wuhrer, M.; Kohler, J.J.; Bonger, K.M.; Boltje, T.J. & Toes, R.E.M. (2023), A photoaffinity glycan-labeling approach to investigate immunoglobulin glycan-binding partners, Glycobiology 33(9): 732-744.
- Naber, A.; Demus, D.; Slieker, R.; Nicolardi, S.; Beulens, J.W.J.; Elders, P.J.M.; Lieverse, A.G.; Sijbrands, E.J.G.; Hart, L.M.; Wuhrer, M. & Hoek, M. van (2023), Apolipoprotein-CIII O-glycosylation, a link between GALNT2 and plasma lipids, International Journal of Molecular Sciences 24(19).
- Marco, F. di; Blöchl, C.; Esser-Skala, W.; Schäpertöns, V.; Zhang, T.; Wuhrer, M.; Sandra, K.; Wohlschlager, T. & Huber, C.G. (2023), Glycoproteomics of a single protein: revealing tens of thousands of Myozyme glycoforms by hybrid HPLC-MS approaches, Molecular & Cellular Proteomics 22(9).
- Svecla, M.; Nour, J.; Bladergroen, M.R.; Nicolardi, S.; Zhang, T.; Beretta, G.; Wuhrer, M.; Norata, G.D. & Falck, D. (2023), Impact of asialoglycoprotein receptor and mannose receptor deficiency on murine plasma N-glycome profiles, Molecular & Cellular Proteomics 22(9).
- Wang, W.; Nier, C.R. de; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2023), In-depth glycoproteomic assay of urinary prostatic acid phosphatase, ACS Measurement Science Au 4(1): 117-126.
- Frkatovic-Hodzic, A.; Mijakovac, A.; Miskec, K.; Nostaeva, A.; Sharapov, S.Z.; Landini, A.; Haller, T.; Akker, E.V.; Sharma, S.; Cuadrat, R.R.C.; Mangino, M.; Li, Y.; Keser, T.; Rudman, N.; Stambuk, T.; Pucic-Bakovic, M.; Trbojevic-Akmacic, I.; Gudelj, I.; Stambuk, J.; Pribic, T.; Radovani, B.; Tominac, P.; Fischer, K.; Beekman, M.; Wuhrer, M.; Gieger, C.; Schulze, M.B.; Wittenbecher, C.; Polasek, O.; Hayward, C.; Wilson, J.F.; Spector, T.D.; Koettgen, A.; Vuckovic, F.; Aulchenko, Y.S.; Vojta, A.; Kristic, J.; Klaric, L.; Zoldos, V. & Lauc, G. (2023), Mapping of the gene network that regulates glycan clock of ageing, Aging 15(24): 14509-14552.
- Vergoossen, D.L.E.; Plomp, J.J.; Gstottner, C.J.; Fillie-Grijpma, Y.E.; Augustinus, R.; Verpalen, R.L.K.; Wuhrer, M.; Parren, P.W.H.I.; Dominguez-Vega, E.; Maarel, S.M. van der; Verschuuren, J.J.G.M. & Huijbers, M.G. (2022), FUNCTIONAL MONOVALENCY AMPLIFIES THE PATHOGENICITY OF ANTI-MUSK IGG4 IN MYASTHENIA GRAVIS, Muscle & Nerve 65: S10-S10.
- Grunert, I.; Heinrich, K.; Hingar, M.; Ernst, J.; Winter, M.; Bomans, K.; Wagner, K.; Fevre, A.; Reusch, D.; Wuhrer, M. & Bulau, P. (2022), Comprehensive multidimensional liquid chromatography-mass spectrometry for the characterization of charge variants of a bispecific antibody, Journal of The American Society for Mass Spectrometry 33(12): 2319-2327.
- Falck, D.; Lechmann, M.; Momcilovic, A.; Thomann, M.; Koeleman, C.A.M.; Jany, C.; Malik, S.; Wuhrer, M. & Reusch, D. (2022), Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model, mAbs 14(1).
- Kenno, S.; Gieseler-Tillmann, J.; Kordowski, A.; Borus, S.; Bieber, K.; Ludwig, R.; Lux, A.; Wuhrer, M.; Nimmerjahn, F. & Köhl, J. (2022), The C5a/C5aR1 axis drives autoimmune inflammation in pemphigoid disease through the control of early Tfh cell activation, IgG autoantibody formation and IgG Fc-glycan composition, Molecular Immunology 141: 223-224.
- Zhang, J.; Zon, G. van der; Ma, J.; Mei, H.L.; Cabukusta, B.; Agaser, C.C.; Madunic, K.; Wuhrer, M.; Zhang, T. & Dijke, P. ten (2022), ST3GAL5-catalyzed gangliosides inhibit TGF-beta-induced epithelial-mesenchymal transition via T beta RI degradation, The EMBO Journal 42.
- Levink, I.J.M.; Klatte, D.C.F.; Hanna-Sawires, R.G.; Vreeker, G.C.M.; Ibrahim, I.S.; Burgt, Y.E.M. van der; Overbeek, K.A.; Koopmann, B.D.M.; Cahen, D.L.; Fuhler, G.M.; Wuhrer, M.; Bonsing, B.A.; Tollenaar, R.A.E.M.; Vleggaar, F.P.; Vasen, H.F.A.; Leerdam, M.E. van; Bruno, M.J. & Mesker, W.E. (2022), Longitudinal changes of serum protein N-Glycan levels for earlier detection of pancreatic cancer in high-risk individuals, Pancreatology 22(4): 497-506.
- Kissel, T.; Toes, R.E.M.; Huizinga, T.W.J. & Wuhrer, M. (2022), Glycobiology of rheumatic diseases, Nature Reviews Rheumatology 19.
- Vanacore, A.; Vitiello, G.; Wanke, A.; Cavasso, D.; Clifton, L.A.; Mahdi, L.; Campanero-Rhodes, M.A.; Solis, D.; Wuhrer, M.; Nicolardi, S.; Molinaro, A.; Marchetti, R.; Zuccaro, A.; Paduano, L. & Silipo, A. (2022), Lipopolysaccharide O-antigen molecular and supramolecular modifications of plant root microbiota are pivotal for host recognition, Carbohydrate Polymers 277.
- Pongracz, T.; Nouta, J.; Wang, W.J.; Meijgaarden, K.E. van; Linty, F.; Vidarsson, G.; Joosten, S.A.; Ottenhoff, T.H.M.; Hokke, C.H.; Vries, J.J.C. de; Arbous, S.M.; Roukens, A.H.E.; Wuhrer, M.; BEAT-COVID Grp & COVID-19 Grp (2022), Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19, EBioMedicine 78.
- Sustic, T.; Coillie, J. van; Larsen, M.D.; Derksen, N.I.L.; Szittner, Z.; Nouta, J.; Wang, W.J.; Damelang, T.; Rebergen, I.; Linty, F.; Visser, R.; Mok, J.Y.; Geerdes, D.M.; Esch, W.J.E. van; Taeye, S.W. de; Gils, M.J. van; Watering, L. van de; Schoot, C.E. van der; Wuhrer, M.; Rispens, T. & Vidarsson, G. (2022), Immunoassay for quantification of antigen-specific IgG fucosylation, EBioMedicine 81.
- Kissel, T.; Hafkenscheid, L.; Wesemael, T.J.; Tamai, M.; Kawashiri, S.Y.; Kawakami, A.; El-Gabalawy, H.S.; Schaardenburg, D.; Rantapaa-Dahlqvist, S.; Wuhrer, M.; Mil, A.H.M.V.V.; Allaart, C.F.; Woude, D.; Scherer, H.U.; Toes, R.E.M. & Huizinga, T.W.J. (2022), IgG Anti-Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ∼1,500 Samples, Arthritis & Rheumatology 74(7): 1147-1158.
- Trbojevic-Akmaciic, I.; Lageveen-Kammeijer, G.S.M.; Heijs, B.; Petrovic, T.; Deris, H.; Wuhrer, M. & Lauc, G. (2022), High-throughput glycomic methods, Chemical Reviews 122(20).
- Boyaval, F.; Dalebout, H.; Zeijl, R. van; Wang, W.J.; Farina-Sarasqueta, A.; Lageveen-Kammeijer, G.S.M.; Boonstra, J.J.; McDonnell, L.A.; Wuhrer, M.; Morreau, H. & Heijs, B. (2022), High-Mannose N-glycans as malignant progression markers in early-stage colorectal cancer, Cancers 14(6).
- Wang, D.; Maduni, K.; Zhang, T.; Mayboroda, O.A.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2022), High diversity of glycosphingolipid glycans of colorectal cancer cell lines reflects the cellular differentiation phenotype, Molecular & Cellular Proteomics 21(6).
- Wang, D.; Zhang, T.; Madunic, K.; Waard, A.A. de; Blochl, C.; Mayboroda, O.A.; Griffioen, M.; Spaapen, R.M.; Huber, C.G.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2022), Glycosphingolipid-glycan signatures of acute myeloid leukemia cell lines reflect hematopoietic differentiation, Journal of Proteome Research 21(4): 1029-1040.
- Nicolardi, S.; Danuser, R.; Dotz, V.; Dominguez-Vega, E.; Kaabi, A. al; Beurret, M.; Anish, C. & Wuhrer, M. (2022), Glycan and protein analysis of glycoengineered bacterial E. coli vaccines by MALDI-in-source decay FT-ICR mass spectrometry, Analytical Chemistry 94(12): 4979-4987.
- Lavado-Garcia, J.; Zhang, T.; Cervera, L.; Godia, F. & Wuhrer, M. (2022), Differential N- and O-glycosylation signatures of HIV-1 Gag virus-like particles and coproduced extracellular vesicles, Biotechnology and Bioengineering 119(5): 1207-1221.
- Haan, N. de; Pucic-Bakovic, M.; Novokmet, M.; Falck, D.; Lageveen-Kammeijer, G.; Razdorov, G.; Vuckovic, F.; Trbojevic-Akmacic, I.; Gornik, O.; Hanic, M.; Wuhrer, M.; Lauc, G. & Human Glycome Project (2022), Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples, Glycobiology 32(8): 651-663.
- Grunert, I.; Heinrich, K.; Ernst, J.; Hingar, M.; Briguet, A.; Leiss, M.; Wuhrer, M.; Reusch, D. & Bulau, P. (2022), Detailed analytical characterization of a bispecific IgG1 CrossMab antibody of the knob-into-hole format applying various stress conditions revealed pronounced stability, ACS Omega 7(4): 3671-3679.
- Chinello, C.; Haan, N. de; Capitoli, G.; Trezzi, B.; Radice, A.; Pagani, L.; Criscuolo, L.; Signorini, S.; Galimberti, S.; Sinico, R.A.; Wuhrer, M. & Magni, F. (2022), Definition of IgG subclass-specific glycopatterns in idiopathic membranous nephropathy: Aberrant IgG glycoforms in blood, International Journal of Molecular Sciences 23(9).
- Pongracz, T.; Vidarsson, G. & Wuhrer, M. (2022), Antibody glycosylation in COVID-19, Glycoconjugate Journal 39.
- Rodriguez, E.; Boelaars, K.; Brown, K.; Madunic, K.; Ee, T. van; Dijk, F.; Verheij, J.; Li, R.J.E.; Schetters, S.T.T.; Meijer, L.L.; Large, T.Y.S. le; Driehuis, E.; Clevers, H.; Bruijns, S.C.M.; O'Toole, T.; Vliet, S.J. van; Bijlsma, M.F.; Wuhrer, M.; Kazemier, G.; Giovannetti, E.; Garcia-Vallejo, J.J. & Kooyk, Y. van (2022), Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits, Communications Biology 5(1).
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- Tillmann Jenny, Kovacs Balint, Kordowski Anna, Wuhrer Manfred, Ludwig Ralf, Karsten Christian M. & Koehl Joerg (2019), THE C5a/C5aR1 AXIS DRIVES THE DEVELOPMENT OF AUTOIMMUNE SKIN BLISTERING DISEASE THROUGH REGULATION OF IGG AUTO-ANTIBODY PRODUCTION, IGG1 FC GLYCOSYLATION AND CYTOKINE PRODUCTION, Molecular Immunology 114: 442-443.
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- Biwi, J.; Clarisse, C.; Biot, C.; Kozak, R.P.; Madunic, K.; Mortuaire, M.; Wuhrer, M.; Spencer, D.I.R.; Schulz, C.; Guerardel, Y.; Lefebvre, T. & Vercoutter-Edouart, A.S. (2019), OGT Controls the Expression and the Glycosylation of E-cadherin, and Affects Glycosphingolipid Structures in Human Colon Cell Lines, Proteomics 19(21-22).
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- Lippold, S.; Nicolardi, S.; Wuhrer, M. & Falck, D. (2019), Proteoform-Resolved Fc & x264;RIIIa Binding Assay for Fab Glycosylated Monoclonal Antibodies Achieved by Affinity Chromatography Mass Spectrometry of Fc Moieties, Frontiers in Chemistry 7.
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- Hafkenscheid, L.; Moel, E. de; Smolik, I.; Tanner, S.; Meng, X.B.; Jansen, B.C.; Bondt, A.; Wuhrer, M.; Huizinga, T.W.J.; Toes, R.E.M.; El-Gabalawy, H. & Scherer, H.U. (2019), N-Linked Glycans in the Variable Domain of IgG Anti-Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis, Arthritis and Rheumatology.
- Kissel, T.; Schie, K.A. van; Hafkenscheid, L.; Lundquist, A.; Kokkonen, H.; Wuhrer, M.; Huizinga, T.W.J.; Scherer, H.U.; Toes, R. & Rantapaa-Dahlqvist, S. (2019), On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis, Annals of the Rheumatic Diseases 78(12): 1616-1620.
- Hafkenscheid Lise, de Moel Emma C., Smolik Irene, Meng Xiaobo, Tanner Stacy, Jansen Bas C., Bondt Albert, Wuhrer Manfred, Huizinga Thomas, Toes Rene, El-Gabalawy Hani & Scherer Hans Ulrich (2019), N-LINKED GLYCANS IN THE VARIABLE DOMAIN OF ACPA-IGG IN THE DEVELOPMENT OF RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 78: 228-229.
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- Pirro, M.; Schoof, E.; Vliet, S.J. van; Rombouts, Y.; Stella, A.; Ru, A. de; Mohammed, Y.; Wuhrer, M.; Veelen, P.A. van & Hensbergen, P.J. (2019), Glycoproteomic Analysis of MGL-Binding Proteins on Acute T-Cell Leukemia Cells, Journal of Proteome Research 18(3).
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- Zhang, T.; Waard, A.A. de; Wuhrer, M. & Spaapen, R.M. (2019), The Role of Glycosphingolipids in Immune Cell Functions, Frontiers in Immunology 10.
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- Haan, N. de; Tol, M. van; Driessen, G.; Wuhrer, M. & Lankester, A. (2018), IgG Fc Glycosylation After Hematopoietic Stem Cell Transplantation is Dissimilar to Donor Profiles, Bone Marrow Transplantation 53: 631-632.
- Stavenhagen, K.; Kayili, H.M.; Holst, S.; Koeleman, C.A.M.; Engel, R.; Wouters, D.; Zeerleder, S.; Salih, B. & Wuhrer, M. (2018), N- and O-glycosylation Analysis of Human C1-inhibitor Reveals Extensive Mucin-type O-Glycosylation, Molecular and Cellular Proteomics 17(6): 1225-1238.
- Bondt, A.; Hafkenscheid, L.; Falck, D.; Kuijper, T.M.; Rombouts, Y.; Hazes, J.M.W.; Wuhrer, M. & Dolhain, R.J.E.M. (2018), ACPA IgG galactosylation associates with disease activity in pregnant patients with rheumatoid arthritis, Annals of the Rheumatic Diseases 77(8): 1130-1136.
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- Culver Emma, van de Bovenkamp Fleur Sanne, Derksen Ninotska, Cargill Tamsin, Koeleman Carolien, Neef Lisa, Barnes Eleanor, Aalberse Rob, Wuhrer Manfred & Rispens Theo (2018), ALTERED FC AND FAB GLYCOSYLATION STATUS IN PATIENTS WITH IGG4-RELATED SCLEROSING CHOLANGITIS AND AUTOIMMUNE PANCREATITIS, Gut 67: A155-A155.
- Kammeijer, G.S.M.; Nouta, J.; Rosette, J.J.M.C.H. de la; Reijke, T.M. de & Wuhrer, M. (2018), An In-Depth Glycosylation Assay for Urinary Prostate-Specific Antigen, Analytical Chemistry 90(7): 4414-4421.
- Dekkers, G.; Bentlage, A.E.H.; Plomp, R.; Visser, R.; Koeleman, C.A.M.; Beentjes, A.; Mok, J.Y.; Esch, W.J.E. van; Wuhrer, M.; Rispens, T. & Vidarsson, G. (2018), Conserved Fc gamma R- glycan discriminates between fucosylated and afucosylated IgG in humans and mice, Molecular Immunology 94: 54-60.
- Dimitrov, B.; Himmelreich, N.; Ederveen, A.L.H.; Luchtenborg, C.; Okun, J.G.; Breuer, M.; Hutter, A.M.; Carl, M.; Guglielmi, L.; Hellwig, A.; Thiemann, K.C.; Jost, M.; Peters, V.; Staufner, C.; Hoffmann, G.F.; Hackenberg, A.; Paramasivam, N.; Wiemann, S.; Eils, R.; Schlesner, M.; Strahl, S.; Brugger, B.; Wuhrer, M.; Korenke, G.C. & Thiel, C. (2018), Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG, Molecular Genetics and Metabolism 123(3): 364-374.
- Engdahl, C.; Bondt, A.; Harre, U.; Raufer, J.; Pfeifle, R.; Camponeschi, A.; Wuhrer, M.; Seeling, M.; Martensson, I.L.; Nimmerjahn, F.; Kronke, G.; Scherer, H.U.; Forsblad-d'Elia, H. & Schett, G. (2018), Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women, Arthritis Research and Therapy 20.
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- Simurina, M.; Haan, N. de; Vuckovic, F.; Kennedy, N.A.; Stambuk, J.; Falck, D.; Trbojevic-Akmacic, I.; Clerc, F.; Razdorov, G.; Khon, A.; Latiano, A.; D'Inca, R.; Danese, S.; Targan, S.; Landers, C.; Dubinsky, M.; McGovern, D.P.B.; Annese, V.; Wuhrer, M.; Lauc, G. & Inflammatory Bowel Dis Biomarkers (2018), Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases, Gastroenterology 154(5): 1320-+.
- Jansen, B.C.; Hafkenscheid, L.; Bondt, A.; Gardner, R.A.; Hendel, J.L.; Wuhrer, M. & Spencer, D.I.R. (2018), HappyTools: A software for high-throughput HPLC data processing and quantitation, PLoS ONE 13(7).
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- Haan, N. de; Tol, M.J.D. van; Driessen, G.J.; Wuhrer, M. & Lankester, A.C. (2018), Immunoglobulin G Fragment Crystallizable Glycosylation Hematopoietic Stem Cell Transplantation Is Dissimilar to Donor Profiles, Frontiers in Immunology 9.
- Knopf, J.; Magorivska, I.; Maier, J.M.; Spitzer, P.; Bilyy, R.; Biermann, M.H.C.; Hychka, K.; Bondt, A.; Wuhrer, M.; Toes, R.E.M.; Schett, G.; Herrmann, M. & Munoz, L.E. (2018), Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG, Journal of Neuroimmunology 320: 19-24.
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- Jacobino, S.R.; Nederend, M.; Reijneveld, J.F.; Augustijn, D.; Jansen, J.H.M.; Meeldijk, J.; Reiding, K.R.; Wuhrer, M.; Coenjaerts, F.E.J.; Hack, C.E.; Bont, L.J. & Leusen, J.H.W. (2018), Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo, mAbs 10(3): 453-462.
- Zhang, Z.J.; Wuhrer, M. & Holst, S. (2018), Serum sialylation changes in cancer, Glycoconjugate Journal 35(2): 139-160.
- Link-Lenczowski, P.; Bubka, M.; Balog, C.I.A.; Koeleman, C.A.M.; Butters, T.D.; Wuhrer, M. & Litynska, A. (2018), The glycomic effect of N-acetylglucosaminyltransferase III overexpression in metastatic melanoma cells. GnT-III modifies highly branched N-glycans, Glycoconjugate Journal 35(2): 217-231.
- Lauc, G.; Vuckovic, F.; Bondt, A.; Pezer, M. & Wuhrer, M. (2018), Trace N-glycans including sulphated species may originate from various plasma glycoproteins and not necessarily IgG, Nature Communications 9.
- Schie, K.A. van; Kruithof, S.; Ooijevaar-de Heer, P.; Derksen, N.I.L.; Bovenkamp, F.S. van de; Saris, A.; Vidarsson, G.; Bentlage, A.E.H.; Jiskoot, W.; Romeijn, S.; Koning, R.I.; Bos, E.; Stork, E.M.; Koeleman, C.A.M.; Wuhrer, M.; Wolbink, G. & Rispens, T. (2018), Restricted immune activation and internalisation of anti-idiotype complexes between drug and antidrug antibodies, Annals of the Rheumatic Diseases 77(10): 1471-1479.
- Dotz, V.; Lemmers, R.F.H.; Reiding, K.R.; Ederveen, A.L.H.; Lieverse, A.G.; Mulder, M.T.; Sijbrands, E.J.G.; Wuhrer, M. & Hoek, M. van (2018), Plasma protein N-glycan signatures of type 2 diabetes, BBA - General Subjects 1862(12): 2613-2622.
- Clerc, F.; Novokmet, M.; Dotz, V.; Reiding, K.R.; Haan, N. de; Kammeijer, G.S.M.; Dalebout, H.; Bladergroen, M.R.; Vukovic, F.; Rapp, E.; Targan, S.R.; Barron, G.; Manetti, N.; Latiano, A.; McGovern, D.P.B.; Annese, V.; Lauc, G.; Wuhrer, M. & IBD-BIOM Consortium (2018), Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases, Gastroenterology 155(3): 829-843.
- de Haan Noortje, Holst Stephanie, Kammeijer Guinevere, Heijs Bram, Falck David, Reiding Karli & Wuhrer Manfred (2018), Linkage-specific sialic acid derivatization strategies for mass spectrometric profiling of glycans and glycopeptides in complex samples and tissues, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256.
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- Vreeker, G.C.M.; Nicolardi, S.; Bladergroen, M.R.; Plas, C.J. van der; Mesker, W.E.; Tollenaar, R.A.E.M.; Burgt, Y.E.M. van der & Wuhrer, M. (2018), Automated Plasma Glycomics with Linkage-Specific Sialic Acid Esterification and Ultrahigh Resolution MS, Analytical Chemistry 90(20): 11955-11961.
- Westhrin Marita, Kovcic Vlado, Bondt Albert, Holst Stephanie, Zhang Zeijan, Slordahl Tobias, Sundan Anders, Waage Anders, Wuhrer Manfred & Standal Therese (2018), A role for immunoglobulins in the osteolytic bone disease of multiple myeloma, Journal of Bone and Mineral Research 33: 341-341.
- Engel, R.; Delvasto-Nunez, L.; Roem, D.; Mierlo, G. van; Holst, S.; Ederveen, A.L.H.; Buul, J.D. van; Wuhrer, M.; Wouters, D. & Zeerleder, S. (2018), alpha 1-Antichymotrypsin Present in Therapeutic Cl-Inhibitor Products Competes with Selectin-Sialyl Lewis(X) Interaction, Thrombosis and Haemostasis 118(12): 2134-2144.
- Epp, A.; Hobusch, J.; Bartsch, Y.C.; Petry, J.; Lilienthal, G.M.; Koeleman, C.A.M.; Eschweiler, S.; Mobs, C.; Hall, A.; Morris, S.C.; Braumann, D.; Engellenner, C.; Bitterling, J.; Rahmoller, J.; Leliavski, A.; Thurmann, R.; Collin, M.; Moremen, K.W.; Strait, R.T.; Blanchard, V.; Petersen, A.; Gemoll, T.; Habermann, J.K.; Petersen, F.; Nandy, A.; Kahlert, H.; Hertl, M.; Wuhrer, M.; Pfutzner, W.; Jappe, U.; Finkelman, F.D. & Ehlers, M. (2018), Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions, Journal of Allergy and Clinical Immunology 141(1): 399-402.
- Sonneveld, M.E.; Koeleman, C.A.M.; Plomp, H.R.; Wuhrer, M.; Schoot, C.E. van der & Vidarsson, G. (2018), Fc-Glycosylation in Human IgG1 and IgG3 Is Similar for Both Total and Anti-Red-Blood Cell Anti-K Antibodies, Frontiers in Immunology 9.
- Ferrantelli, E.; Farhat, K.; Ederveen, A.L.H.; Reiding, K.R.; Beelen, R.H.J.; Ittersum, F.J. van; Wuhrer, M. & Dotz, V. (2018), Effluent and serum protein N-glycosylation is associated with inflammation and peritoneal membrane transport characteristics in peritoneal dialysis patients, Scientific Reports 8.
- Kotsias Maximilianos, Kozak Radoslaw P., Gardner Richard A., Wuhrer Manfred & Spencer Daniel I. (2018), Improved and semi-automated reductive beta-elimination workflow for higher throughput protein O-glycosylation, Glycobiology 28(12): 1090-1090.
- Haan, N. de; Boeddha, N.P.; Ekinci, E.; Reiding, K.R.; Emonts, M.; Hazelzet, J.A.; Wuhrer, M. & Driessen, G.J. (2018), Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis, mBio 9(3).
- Schmidt, C.Q.; Ederveen, A.L.H.; Harder, M.J.; Wuhrer, M.; Stehle, T. & Blaum, B.S. (2018), Biophysical analysis of sialic acid recognition by the complement regulator Factor H, Glycobiology 28(10): 765-773.
- Nicolardi S., Burgt Y.E.M. van der, Codée J.D.C., Wuhrer M., Hokke C.H. & Chiodo F. (2017), Structural Characterization of Biofunctionalized Gold Nanoparticles by Ultrahigh-Resolution Mass Spectrometry, ACS Nano 11(8): 8257-8264.
- Laan, L.C.; Williams, A.R.; Stavenhagen, K.; Giera, M.; Kooij, G.; Vlasakov, I.; Kalay, H.; Kringel, H.; Nejsum, P.; Thamsborg, S.M.; Wuhrer, M.; Dijkstra, C.D.; Cummings, R.D. & , I. van die (2017), The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells, FASEB Journal 31(2): 719-731.
- Haan, N. de; Reiding, K.R.; Kristic, J.; Ederveen, A.L.H.; Lauc, G. & Wuhrer, M. (2017), The N-glycosylation of Mouse immunoglobulin G (igg)-Fragment crystallizable Differs Between igg subclasses and strains, Frontiers in Immunology 8.
- Plomp, R.; Ruhaak, L.R.; Uh, H.W.; Reiding, K.R.; Selman, M.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Beekman, M. & Wuhrer, M. (2017), Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health, Scientific Reports 7.
- Nicolardi, S.; Burgt, Y.E.M. van der; Codee, J.D.C.; Wuhrer, M.; Hokke, C.H. & Chiodo, F. (2017), Structural Characterization of Biofunctionalized Gold Nanoparticles by Ultrahigh-Resolution Mass Spectrometry, ACS Nano 11(8): 8257-8264.
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- Kammeijer, G.S.M.; Jansen, B.C.; Kohler, I.; Heemskerk, A.A.M.; Mayboroda, O.A.; Hensbergen, P.J.; Schappler, J. & Wuhrer, M. (2017), Sialic acid linkage differentiation of glycopeptides using capillary electrophoresis - electrospray ionization - mass spectrometry, Scientific Reports 7.
- Sonneveld, M.E.; Haas, M. de; Koeleman, C.; Haan, N. de; Zeerleder, S.S.; Ligthart, P.C.; Wuhrer, M.; Schoot, C.E. van der & Vidarsson, G. (2017), Patients with IgG1-anti-red blood cell autoantibodies show aberrant Fc-glycosylation, Scientific Reports 7.
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- Stavenhagen, K.; Plomp, R. & Wuhrer, M. (2015), Site-Specific Protein N- and O-Glycosylation Analysis by a C18-Porous Graphitized Carbon-Liquid Chromatography-Electrospray Ionization Mass Spectrometry Approach Using Pronase Treated Glycopeptides, Analytical Chemistry 87(23): 11691-11699.
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- Reiding, K.R.; Blank, D.; Kuijper, D.M.; Deelder, A.M. & Wuhrer, M. (2014), High-Throughput Profiling of Protein N-Glycosylation by MALDI-TOF-MS Employing Linkage-Specific Sialic Acid Esterification, Analytical Chemistry 86(12): 5784-5793.
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- Huffman, J.E.; Pucic-Bakovic, M.; Klaric, L.; Hennig, R.; Selman, M.H.J.; Vuckovic, F.; Novokmet, M.; Kristic, J.; Borowiak, M.; Muth, T.; Polasek, O.; Razdorov, G.; Gornik, O.; Plomp, R.; Theodoratou, E.; Wright, A.F.; Rudan, I.; Hayward, C.; Campbell, H.; Deelder, A.M.; Reichl, U.; Aulchenko, Y.S.; Rapp, E.; Wuhrer, M. & Lauc, G. (2014), Comparative Performance of Four Methods for High-throughput Glycosylation Analysis of Immunoglobulin G in Genetic and Epidemiological Research, Molecular and Cellular Proteomics 13(6): 1598-1610.
- Kapur, R.; Kustiawan, I.; Vestrheim, A.; Koeleman, C.A.M.; Visser, R.; Einarsdottir, H.K.; Porcelijn, L.; Jackson, D.; Kumpel, B.; Deelder, A.M.; Blank, D.; Skogen, B.; Killie, M.K.; Michaelsen, T.E.; Haas, M. de; Rispens, T.; Schoot, C.E. van der; Wuhrer, M. & Vidarsson, G. (2014), A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy, Blood 123(4): 471-480.
- Nagelkerke, S.Q.; Dekkers, G.; Kustiawan, I.; Bovenkamp, F.S. van de; Geissler, J.; Plomp, R.; Wuhrer, M.; Vidarsson, G.; Rispens, T.; Berg, T.K. van den & Kuijpers, T.W. (2014), Inhibition of Fc gamma R-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and Fc gamma RIIb in human macrophages, Blood 124(25): 3709-3718.
- Rombouts, Y.; Willemze, A.; Beers, J.J.B.C. van; Shi, J.; Kerkman, P.F.; Janssen, G.M.C.; Veelen, P.A. van; Zaldumbide, A.; Hoeben, R.C.; Pruijn, G.J.; Deelder, A.M.; Wolbink, G.; Rispens, T.; Garcia-Vallejo, J.J.; Kooyk, Y. van; Huizinga, T.W.J.; Wuhrer, M.; Trouw, L.A.; Scherer, H.U. & Toes, R.E.M. (2014), HYPERGLYCOSYLATION OF ACPA-IGG VARIABLE DOMAINS MODULATES REACTIVITY TO CITRULLINATED ANTIGENS, Annals of the Rheumatic Diseases 73: A19-A19.
- Scherer, H.U.; Rombouts, Y.; Willemze, A.; Beers, J. van; Shi, J.; Kerkman, P.; Janssen, G.; Veelen, P. van; Zaldumbide, A.; Hoeben, R.; Pruijn, G.; Deelder, A.; Wolbink, G.J.; Rispens, T.; Huizinga, T.W.; Wuhrer, M.; Trouw, L. & Toes, R. (2014), A HIGH FREQUENCY OF N-GLYCANS IN THE ACPA-IGG VARIABLE DOMAIN MODULATES REACTIVITY TO CITRULLINATED ANTIGENS, Annals of the Rheumatic Diseases 73: 129-129.
- Gardinassi, L.G.; Dotz, V.; Ederveen, A.H.; Almeida, R.P. de; Costa, C.H.N.; Costa, D.L.; Jesus, A.R. de; Mayboroda, O.A.; Garcia, G.R.; Wuhrer, M. & Santosa, I.K.F.D. (2014), Clinical Severity of Visceral Leishmaniasis Is Associated with Changes in Immunoglobulin G Fc N-Glycosylation, mBio 5(6).
- Plomp, R.; Hensbergen, P.J.; Rombouts, Y.; Zauner, G.; Dragan, I.; Koeleman, C.A.M.; Deelder, A.M. & Wuhrer, M. (2014), Site-Specific N-Glycosylation Analysis of Human Immunoglobulin E, Journal of Proteome Research 13(2): 536-546.
- Scherpenzeel, M. van; Timal, S.; Rymen, D.; Hoischen, A.; Wuhrer, M.; Hipgrave-Ederveen, A.; Grunewald, S.; Peanne, R.; Saada, A.; Edvardson, S.; Gronborg, S.; Ruijter, G.; Kattentidt-Mouravieva, A.; Brum, J.M.; Freckmann, M.L.; Tomkins, S.; Jalan, A.; Prochazkova, D.; Ondruskova, N.; Hansikova, H.; Willemsen, M.A.; Hensbergen, P.J.; Matthijs, G.; Wevers, R.A.; Veltman, J.A.; Morava, E. & Lefeber, D.J. (2014), Diagnostic serum glycosylation profile in patients with intellectual disability as a result of MAN1B1 deficiency, Brain 137: 1030-1038.
- Bondt, A.; Rombouts, Y.; Selman, M.H.J.; Hensbergen, P.J.; Reiding, K.R.; Hazes, J.M.W.; Dolhain, R.J.E.M. & Wuhrer, M. (2014), Immunoglobulin G (IgG) Fab Glycosylation Analysis Using a New Mass Spectrometric High-throughput Profiling Method Reveals Pregnancy-associated Changes, Molecular and Cellular Proteomics 13(11): 3029-3039.
- Morgan, M.; Stavenhagen, K.; Koeleman, C.; Hipgrave-Ederveen, A.; Harper, L.; Jacobs, B.; Savage, C.; Jefferis, R.; Deelder, A. & Wuhrer, M. (2013), Galactosylation and sialylation of anti-proteinase 3 antibodies in granulomatosis with polyangiitis is associated with increased inflammatory cytokines, Presse M�dicale 42(4): 761-761.
- Kapur, R.; Vestrheim, A.; Koeleman, C.A.M.; Porcelijn, L.; Jackson, D.; Kumpel, B.; Deelder, A.M.; Blank, D.; Skogen, B.; Killie, M.K.; Michaelsen, T.E.; Haas, M. de; Schoot, C.E. van der; Wuhrer, M. & Vidarsson, G. (2013), A PROMINENT LACK OF IGG1 FC-FUCOSYLATION OF PLATELET-ALLOANTIBODIES IN PREGNANCY, Vox Sanguinis 105: 13-14.
- Scherer, H.U.; Rombouts, Y.; Ewing, E.; Stadt, L.A. van de; Selman, M.H.; Deelder, A.M.; Huizinga, T.W.; Wuhrer, M.; Schaardenburg, D. van & Toes, R.E. (2013), ANTI-CITRULLINATED PROTEIN ANTIBODY SPECIFIC FC GLYCOSYLATION PATTERNS IN PATIENTS WITH ARTHRALGIA, Annals of the Rheumatic Diseases 72: 116-117.
- Zauner, G.; Selman, M.H.J.; Bondt, A.; Rombouts, Y.; Blank, D.; Deelder, A.M. & Wuhrer, M. (2013), Glycoproteomic Analysis of Antibodies, Molecular and Cellular Proteomics 12(4): 856-865.
- Bondt, A.; Selman, M.H.J.; Deelder, A.M.; Hazes, J.M.W.; Willemsen, S.P.; Wuhrer, M. & Dolhain, R.J.E.M. (2013), Association between Galactosylation of Immunoglobulin G and Improvement of Rheumatoid Arthritis during Pregnancy Is Independent of Sialylation, Journal of Proteome Research 12(10): 4522-4531.
- Vidarsson, G.; Kapur, R.; Einarsdottir, H.; Wuhrer, M.; Ji, Y.; Porcelijn, L.; Haas, M. de & Schoot, E. van der (2013), MULTIPLE FACTORS DETERMINING THE BIOLOGICAL EFFECT OF ANTI-PLATELET ANTIBODIES, Vox Sanguinis 105: 36-36.
- Bondt, A.; Rombouts, Y.; Selman, M.H.J.; Dolhain, R.J.E.M. & Wuhrer, M. (2013), High-Throughput Immunoglobulin G Fab Glycosylation Profiling Reveals Differential Glycosylation On Fab and Fc, Arthritis and Rheumatism 65: S806-S806.
- Kapur, R.; Einarsdottir, H.; Selman, M.; Scherjon, S.; Koeleman, C.A.M.; Deelder, A.M.; Schoot, C.E. van der; Vidarsson, G. & Wuhrer, M. (2013), COMPARISON OF THE FC GLYCOSYLATION OF FETAL AND MATERNAL IMMUNOGLOBULIN G, Vox Sanguinis 105: 251-251.
- Kempers, A.C.; Scherer, H.U.; Rombouts, Y.; Ewing, E.; Stadt, L.A. van de; Selman, M.H.J.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M.; Schaardenburg, D. van & Toes, R.E.M. (2013), ANTI-CITRULLINATED PROTEIN ANTIBODY SPECIFIC FC GLYCOSYLATION PATTERNS IN ARTHRALGIA PATIENTS, Annals of the Rheumatic Diseases 72: A1-A1.
- Dall'Olio, F.; Vanhooren, V.; Chen, C.C.; Slagboom, P.E.; Wuhrer, M. & Franceschi, C. (2013), N-glycomic biomarkers of biological aging and longevity: A link with inflammaging, Ageing Research Reviews 12(2): 685-698.
- Nicolardi, S.; Burgt, Y.E.M. van der; Wuhrer, M. & Deelder, A.M. (2013), Mapping O-glycosylation of apolipoprotein C-III in MALDI-FT-ICR protein profiles, Proteomics 13(6): 992-1001.
- Ruhaak, L.R.; Koeleman, C.A.M.; Uh, H.W.; Stam, J.C.; Heemst, D. van; Maier, A.B.; Houwing-Duistermaat, J.J.; Hensbergen, P.J.; Slagboom, P.E.; Deelder, A.M. & Wuhrer, M. (2013), Targeted Biomarker Discovery by High Throughput Glycosylation Profiling of Human Plasma Alpha1-Antitrypsin and Immunoglobulin A, PLoS ONE 8(9).
- Holst, S.; Stavenhagen, K.; Balog, C.I.A.; Koeleman, C.A.M.; McDonnell, L.M.; Mayboroda, O.A.; Verhoeven, A.; Mesker, W.E.; Tollenaar, R.A.E.M.; Deelder, A.M. & Wuhrer, M. (2013), Investigations on Aberrant Glycosylation of Glycosphingolipids in Colorectal Cancer Tissues Using Liquid Chromatography and Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry (MALDI-TOF-MS), Molecular and Cellular Proteomics 12(11): 3081-3093.
- Leymarie, N.; Griffin, P.J.; Jonscher, K.; Kolarich, D.; Orlando, R.; McComb, M.; Zaia, J.; Aguilan, J.; Alley, W.R.; Altmann, F.; Ball, L.E.; Basumallick, L.; Bazemore-Walker, C.R.; Behnken, H.; Blank, M.A.; Brown, K.J.; Bunz, S.C.; Cairo, C.W.; Cipollo, J.F.; Daneshfar, R.; Desaire, H.; Drake, R.R.; Go, E.P.; Goldman, R.; Gruber, C.; Halim, A.; Hathout, Y.; Hensbergen, P.J.; Horn, D.M.; Hurum, D.; Jabs, W.; Larson, G.; Ly, M.; Mann, B.F.; Marx, K.; Mechref, Y.; Meyer, B.; Moginger, U.; Neususs, C.; Nilsson, J.; Novotny, M.V.; Nyalwidhe, J.O.; Packer, N.H.; Pompach, P.; Reiz, B.; Resemann, A.; Rohrer, J.S.; Ruthenbeck, A.; Sanda, M.; Schulz, J.M.; Schweiger-Hufnagel, U.; Sihlbom, C.; Song, E.; Staples, G.O.; Suckau, D.; Tang, H.X.; Thaysen-Andersen, M.; Viner, R.I.; An, Y.M.; Valmuv, L.; Wada, Y.; Watson, M.; Windwarder, M.; Whittal, R.; Wuhrer, M.; Zhu, Y.Y. & Zou, C.X. (2013), Interlaboratory Study on Differential Analysis of Protein Glycosylation by Mass Spectrometry: The ABRF Glycoprotein Research Multi-Institutional Study 2012, Molecular and Cellular Proteomics 12(10): 2935-2951.
- Lauc, G.; Huffman, J.E.; Pucic, M.; Zgaga, L.; Adamczyk, B.; Muzinic, A.; Novokmet, M.; Polasek, O.; Gornik, O.; Kristic, J.; Keser, T.; Vitart, V.; Scheijen, B.; Uh, H.W.; Molokhia, M.; Patrick, A.L.; McKeigue, P.; Kolcic, I.; Lukic, I.K.; Swann, O.; Leeuwen, F.N. van; Ruhaak, L.R.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Beekman, M.; Craen, A.J.M. de; Deelder, A.M.; Zeng, Q.; Wang, W.; Hastie, N.D.; Gyllensten, U.; Wilson, J.F.; Wuhrer, M.; Wright, A.F.; Rudd, P.M.; Hayward, C.; Aulchenko, Y.; Campbell, H. & Rudan, I. (2013), Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers, PLoS Genetics 9(1): -.
- Bakovic, M.P.; Selman, M.H.J.; Hoffmann, M.; Rudan, I.; Campbell, H.; Deelder, A.M.; Lauc, G. & Wuhrer, M. (2013), High-Throughput IgG Fc N-Glycosylation Profiling by Mass Spectrometry of Glycopeptides, Journal of Proteome Research 12(2): 821-831.
- Reusch, D.; Haberger, M.; Selman, M.H.J.; Bulau, P.; Deelder, A.M.; Wuhrer, M. & Engler, N. (2013), High-throughput work flow for IgG Fc-glycosylation analysis of biotechnological samples, Analytical Biochemistry 432(2): 82-89.
- Wuhrer, M. (2013), Glycomics using mass spectrometry, Glycoconjugate Journal 30(1): 11-22.
- Wang, J.; Balog, C.I.; Stavenhagen, K.; Koeleman, C.A.; Selman, M.H.; Deelder, A.M.; Huizinga, T.W.; Toes, R.E.; Wuhrer, M. & Scherer, H.U. (2013), MODULATING FC-LINKED GLYCOSYLATION PATTERNS OF HUMAN IGG1, Annals of the Rheumatic Diseases 71: 312-312.
- Einarsdottir, H.K.; Selman, M.H.J.; Kapur, R.; Scherjon, S.; Koeleman, C.A.M.; Deelder, A.M.; Schoot, C.E. van der; Vidarsson, G. & Wuhrer, M. (2013), Comparison of the Fc glycosylation of fetal and maternal immunoglobulin G, Glycoconjugate Journal 30(2): 147-157.
- Heemskerk, A.A.M.; Wuhrer, M.; Busnel, J.M.; Koeleman, C.A.M.; Selman, M.H.J.; Vidarsson, G.; Kapur, R.; Schoenmaker, B.; Derks, R.J.E.; Deelder, A.M. & Mayboroda, O.A. (2013), Coupling porous sheathless interface MS with transient-ITP in neutral capillaries for improved sensitivity in glycopeptide analysis, ELECTROPHORESIS 34(3): 383-387.
- Scherer, H.U.; Rombouts, Y.; Ewing, E.; Stadt, L. van de; Selman, M.H.J.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M.; Schaardenburg, D. van & Toes, R.E.M. (2012), Anti-Citrullinated Protein Antibody Specific Fc Glycosylation Patterns in Arthralgia Patients., Arthritis and Rheumatism 64(10): S514-S514.
- Uh, H.W.; Tsonaka, R.; Wuhrer, M.; Slagboom, E. & Houwing-Duistermaat, J. (2012), Integrating Multiple Glycans and Genetic Data Using Joint Modeling Techniques: An Application in Leiden Longevity Study, Genetic Epidemiology 36(7): 777-777.
- Kozak, R.P.; Royle, L.; Gardner, R.A.; Fernandes, D.L. & Wuhrer, M. (2012), Suppression of peeling during the release of O-glycans by hydrazinolysis., Analytical Biochemistry 423(1).
- Kozak, R.P.; Royle, L.; Gardner, R.A.; Fernandes, D.L. & Wuhrer, M. (2012), Suppression of peeling during the release of O-glycans by hydrazinolysis, Analytical Biochemistry 423(1): 119-128.
- Selman, M.H.J.; Derks, R.J.E.; Bondt, A.; Palmblad, M.; Schoenmaker, B.; Koeleman, C.A.M.; Geijn, F.E. van de; Dolhain, R.J.E.M.; Deelder, A.M. & Wuhrer, M. (2012), Fc specific IgG glycosylation profiling by robust nano-reverse phase HPLC-MS using a sheath-flow ESI sprayer interface, Journal of Proteomics 75(4): 1318-1329.
- Pacchiarotta, T.; Hensbergen, P.J.; Wuhrer, M.; Nieuwkoop, C. van; Nevedomskaya, E.; Derks, R.J.E.; Schoenmaker, B.; Koeleman, C.A.M.; Dissel, J. van; Deelder, A.M. & Mayboroda, O.A. (2012), Fibrinogen alpha chain O-glycopeptides as possible markers of urinary tract infection, Journal of Proteomics 75(3): 1067-1073.
- Selman, M.H.J.; Jong, S.E. de; Soonawala, D.; Kroon, F.P.; Adegnika, A.A.; Deelder, A.M.; Hokke, C.H.; Yazdanbakhsh, M. & Wuhrer, M. (2012), Changes in Antigen-specific IgG1 Fc N-glycosylation Upon Influenza and Tetanus Vaccination.
- Zauner, G.; Hoffmann, M.; Rapp, E.; Koeleman, C.A.M.; Dragan, I.; Deelder, A.M.; Wuhrer, M. & Hensbergen, P.J. (2012), Glycoproteomic Analysis of Human Fibrinogen Reveals Novel Regions of O-Glycosylation, Journal of Proteome Research 11(12): 5804-5814.
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- Zauner, G.; Kozak, R.P.; Gardner, R.A.; Fernandes, D.L.; Deelder, A.M. & Wuhrer, M. (2012), Protein O-glycosylation analysis, Biological Chemistry 393(8): 687-708.
- Lebeer, S.; Claes, I.J.J.; Balog, C.I.A.; Schoofs, G.; Verhoeven, T.L.A.; Nys, K.; Ossowski, I. von; Vos, W.M. de; Tytgat, H.L.P.; Agostinis, P.; Palva, A.; Damme, E.J.M. van; Deelder, A.M.; Keersmaecker, S.C.J. de; Wuhrer, M. & Vanderleyden, J. (2012), The major secreted protein Msp1/p75 is O-glycosylated in Lactobacillus rhamnosus GG, Microbial Cell Factories 11: -.
- Carlsson, M.C.; Balog, C.I.A.; Kilsgard, O.; Hellmark, T.; Bakoush, O.; Segelmark, M.; Ferno, M.; Olsson, H.; Malmstrom, J.; Wuhrer, M. & Leffler, H. (2012), Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease, BBA - General Subjects 1820(9): 1366-1372.
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- Bruggink, C.; Poorthuis, B.H.M.; Deelder, A.M. & Wuhrer, M. (2012), Analysis of urinary oligosaccharides in lysosomal storage disorders by capillary high-performance anion-exchange chromatography-mass spectrometry, Analytical and Bioanalytical Chemistry 403(6): 1671-1683.
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- Balog, C.I.A.; Stavenhagen, K.; Fung, W.L.J.; Koeleman, C.A.; McDonnell, L.A.; Verhoeven, A.; Mesker, W.E.; Tollenaar, R.A.E.M.; Deelder, A.M. & Wuhrer, M. (2012), N-glycosylation of Colorectal Cancer Tissues.
- Bondt, A.; Selman, M.H.J.; Hazes, J.M.W.; Deelder, A.M.; Wuhrer, M. & Dolhain, R.J.E.M. (2012), CHANGES IN IGG-FC N-GLYCAN SIALYLATION, GALACTOSYLATION AND FUCOSYLATION INFLUENCE DISEASE ACTIVITY DURING AND AFTER PREGNANCY IN RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 71: -.
- Selman, M.H.J.; Hoffmann, M.; Zauner, G.; McDonnell, L.A.; Balog, C.I.A.; Rapp, E.; Deelder, A.M. & Wuhrer, M. (2012), MALDI-TOF-MS analysis of sialylated glycans and glycopeptides using 4-chloro-alpha-cyanocinnamic acid matrix, Proteomics 12(9): 1337-1348.
- Huhn, C.; Ruhaak, L.R.; Wuhrer, M. & Deelder, A.M. (2012), Hexapeptide library as a universal tool for sample preparation in protein glycosylation analysis, Journal of Proteomics 75(5): 1515-1528.
- Bondt, A.; Selman, M.H.J.; Deelder, A.M.; Hazes, J.M.W.; Wuhrer, M. & Dolhain, R.J.E.M. (2012), Galactosylation, and Not Sialylation, of Immunoglobulin G Is Associated with Improvement of Rheumatoid Arthritis During Pregnancy, Arthritis and Rheumatism 64(10): S504-S504.
- Huhn, C.; Ruhaak, L.R.; Mannhardt, J.; Wuhrer, M.; Neususs, C.; Deelder, A.M. & Meyer, H. (2012), Alignment of laser-induced fluorescence and mass spectrometric detection traces using electrophoretic mobility scaling in CE-LIF-MS of labeled N-glycans, ELECTROPHORESIS 33(4): 563-566.
- Wang, J.; Bax, M.; Balog, C.I.A.; Stavenhagen, K.; Koeleman, C.A.M.; Scherer, H.U.; Deelder, A.M.; Huizinga, T.W.J.; Toes, R.E.M. & Wuhrer, M. (2011), FC-GLYCOSYLATION OF IGG1 IS MODULATED BY B CELL STIMULI, Annals of the Rheumatic Diseases 70.
- Wuhrer, M.; Deelder, A.M. & Burgt, Y.E.M. van der (2011), MASS SPECTROMETRIC GLYCAN REARRANGEMENTS.
- Zauner, G.; Deelder, A.M. & Wuhrer, M. (2011), Recent advances in hydrophilic interaction liquid chromatography (HILIC) for structural glycomics, ELECTROPHORESIS 32(24): 3456-3466.
- Pucic, M.; Knezevic, A.; Vidic, J.; Adamczyk, B.; Novokmet, M.; Polasek, O.; Gornik, O.; Supraha-Goreta, S.; Wormald, M.R.; Redzic, I.; Campbell, H.; Wright, A.; Hastie, N.D.; Wilson, J.F.; Rudan, I.; Wuhrer, M.; Rudd, P.M.; Josic, D. & Lauc, G. (2011), High Throughput Isolation and Glycosylation Analysis of IgG-Variability and Heritability of the IgG Glycome in Three Isolated Human Populations.
- Huffman, J.E.; Knezevic, A.; Vitart, V.; Kattla, J.; Adamczyk, B.; Novokmet, M.; Igl, W.; Pucic, M.; Zgaga, L.; Johannson, A.; Redzic, I.; Gornik, O.; Zemunik, T.; Polasek, O.; Kolcic, I.; Pehlic, M.; Koeleman, C.A.M.; Campbell, S.; Wild, S.H.; Hastie, N.D.; Campbell, H.; Gyllensten, U.; Wuhrer, M.; Wilson, J.F.; Hayward, C.; Rudan, I.; Rudd, P.M.; Wright, A.F. & Lauc, G. (2011), Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults, Human Molecular Genetics 20(24): 5000-5011.
- Taganna, J.; Boer, A.R. de; Wuhrer, M. & Bouckaert, J. (2011), Glycosylation changes as important factors for the susceptibility to urinary tract infection, Biochemical Society Transactions 39: 349-354.
- Selman, M.H.J.; Jong, S.E. de; Soonawala, D.; Kroon, F.P.; Adegnika, A.A.; Deelder, A.M.; Hokke, C.H.; Yazdanbakhsh, M. & Wuhrer, M. (2011), Changes in antigen-specific IgG1 Fc N-glycosylation upon influenza and tetanus vaccination., Molecular & Cellular Proteomics.
- Geijn, F.E. van de; Man, Y.A. de; Wuhrer, M.; Willemsen, S.P.; Deelder, A.M.; Hazes, J.M.W. & Dolhain, R.J.E.M. (2011), Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis, Arthritis Research and Therapy 13(1).
- Wang, J.; Balog, C.I.A.; Stavenhagen, K.; Koeleman, C.A.M.; Scherer, H.U.; Selman, M.H.J.; Deelder, A.M.; Huizinga, T.W.J.; Toes, R.E.M. & Wuhrer, M. (2011), Fc-Glycosylation of IgG1 is Modulated by B-cell Stimuli, Molecular and Cellular Proteomics 10(5).
- Carlsson, M.C.; Cederfur, C.; Schaar, V.; Balog, C.I.A.; Lepur, A.; Touret, F.; Salomonsson, E.; Deelder, A.M.; Ferno, M.; Olsson, H.; Wuhrer, M. & Leffler, H. (2011), Galectin-1-Binding Glycoforms of Haptoglobin with Altered Intracellular Trafficking, and Increase in Metastatic Breast Cancer Patients, PLoS ONE 6(10): -.
- Guhr, T.; Bloem, J.; Derksen, N.I.L.; Wuhrer, M.; Koenderman, A.H.L.; Aalberse, R.C. & Rispens, T. (2011), Enrichment of Sialylated IgG by Lectin Fractionation Does Not Enhance the Efficacy of Immunoglobulin G in a Murine Model of Immune Thrombocytopenia, PLoS ONE 6(6): -.
- Selman, M.H.J.; Niks, E.H.; Titulaer, M.J.; Verschuuren, J.J.G.M.; Wuhrer, M. & Deelder, A.M. (2011), IgG Fc N-Glycosylation Changes in Lambed-Eaton Myasthenic Syndrome and Myasthenia Gravis, Journal of Proteome Research 10(1): 143-152.
- Selman, M.H.J.; Hemayatkar, M.; Deelder, A.M. & Wuhrer, M. (2011), Cotton HILIC SPE Microtips for Microscale Purification and Enrichment of Glycans and Glycopeptides, Analytical Chemistry 83(7): 2492-2499.
- Meevissen, M.H.J.; Balog, C.I.A.; Koeleman, C.A.M.; Doenhoff, M.J.; Schramm, G.; Haas, H.; Deelder, A.M.; Wuhrer, M. & Hokke, C.H. (2011), Targeted Glycoproteomic Analysis Reveals That Kappa-5 is a Major, Uniquely Glycosylated Component of Schistosoma mansoni Egg Antigens, Molecular and Cellular Proteomics 10(5).
- Selman, M.H.J.; McDonnell, L.A.; Palmblad, M.; Ruhaak, L.R.; Deelder, A.M. & Wuhrer, M. (2010), Immunoglobulin G Glycopeptide Profiling by Matrix-Assisted Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Analytical Chemistry 82(3): 1073-1081.
- Huhn, C.; Ramautar, R.; Wuhrer, M. & Somsen, G.W. (2010), Relevance and use of capillary coatings in capillary electrophoresis-mass spectrometry, Analytical and Bioanalytical Chemistry 396(1): 297-314.
- Wuhrer, M.; Remoortere, A. van; Balog, C.I.A.; Deelder, A.M. & Hokke, C.H. (2010), Ligand identification of carbohydrate-binding proteins employing a biotinylated glycan binding assay and tandem mass spectrometry, Analytical Biochemistry 406(2): 132-140.
- Ruhaak, L.R.; Steenvoorden, E.; Koeleman, C.A.M.; Deelder, A.M. & Wuhrer, M. (2010), 2-Picoline-borane: A non-toxic reducing agent for oligosaccharide labeling by reductive amination, Proteomics 10(12): 2330-2336.
- Ruhaak, L.R.; Zauner, G.; Huhn, C.; Bruggink, C.; Deelder, A.M. & Wuhrer, M. (2010), Glycan labeling strategies and their use in identification and quantification, Analytical and Bioanalytical Chemistry 397(8): 3457-3481.
- Bruggink, C.; Poorthuis, B.J.H.M.; Piraud, M.; Froissart, R.; Deelder, A.M. & Wuhrer, M. (2010), Glycan profiling of urine, amniotic fluid and ascitic fluid from galactosialidosis patients reveals novel oligosaccharides with reducing end hexose and aldohexonic acid residues, FEBS Journal 277(14): 2970-2986.
- Zauner, G.; Koeleman, C.A.M.; Deelder, A.M. & Wuhrer, M. (2010), Protein glycosylation analysis by HILIC-LC-MS of Proteinase K-generated N- and O-glycopeptides, Journal of Separation Science 33(6-7): 903-910.
- Ruhaak, L.R.; Uh, H.W.; Beekman, M.; Hokke, C.H.; Westendorp, R.G.J.; Houwing-Duistermaat, J.; Wuhrer, M.; Deelder, A.M. & Sagboom, P.E. (2010), Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health., Journal of Proteome Research.
- Lonardi, E.; Balog, C.I.A.; Deelder, A.M. & Wuhrer, M. (2010), Natural glycan microarrays., Expert Review of Proteomics 7(5): 761-74.
- Scherer, H.U.; Woude, D. van der; Ioan-Facsinay, A.; Bannoudi, H. el; Trouw, L.A.; Wang, J.; Haupl, T.; Burmester, G.R.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M. & Toes, R.E.M. (2010), Glycan profiling of anti-citrullinated protein antibodies (ACPA) isolated from human serum and synovial fluid., Arthritis and Rheumatism.
- Ruhaak, L.R.; Uh, H.W.; Beekman, M.; Koeleman, C.A.M.; Hokke, C.H.; Westendorp, R.G.J.; Wuhrer, M.; Houwing-Duistermaat, J.J.; Slagboom, P.E. & Deelder, A.M. (2010), Decreased Levels of Bisecting GlcNAc Glycoforms of IgG Are Associated with Human Longevity, PLoS ONE 5(9).
- Scherer, H.U.; Woude, D. van der; Ioan-Facsinay, A.; Bannoudi, H. el; Trouw, L.A.; Wang, J.; Haupl, T.; Burmester, G.R.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M. & Toes, R.E.M. (2010), Glycan Profiling of Anti-Citrullinated Protein Antibodies Isolated From Human Serum and Synovial Fluid, Arthritis and Rheumatism 62(6): 1620-1629.
- Eggink, D.; Melchers, M.; Wuhrer, M.; Montfort, T. van; Dey, A.K.; Naaijkens, B.A.; David, K.B.; Douce, V. le; Deelder, A.M.; Kang, K.; Olson, W.C.; Berkhout, B.; Hokke, C.H.; Moore, J.P. & Sanders, R.W. (2010), Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function, Virology 401(2): 236-247.
- Eggink, D.; Melchers, M.; Wuhrer, M.; Montfort, T. van; Dey, A.K.; Naaijkens, B.A.; David, K.B.; Douce, V. le; Deelder, A.M.; Kang, K.; Olson, W.C.; Berkhout, B.; Hokke, C.H.; Moore, J.P. & Sanders, R.W. (2010), Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function (vol 401, pg 236, 2010), Virology 406(1): 162-163.
- Meevissen, M.H.J.; Wuhrer, M.; Doenhoff, M.J.; Schramm, G.; Haas, H.; Deelder, A.M. & Hokke, C.H. (2010), Structural Characterization of Glycans on Omega-1, a Major Schistosoma mansoni Egg Glycoprotein That Drives Th2 Responses, Journal of Proteome Research 9(5): 2630-2642.
- Balog, C.I.A.; Mayboroda, O.A.; Wuhrer, M.; Hokke, C.H.; Deelder, A.M. & Hensbergen, P.J. (2010), Mass Spectrometric Identification of Aberrantly Glycosylated Human Apolipoprotein C-III Peptides in Urine from Schistosoma mansoni-infected Individuals, Molecular and Cellular Proteomics 9(4): 667-681.
- Ruhaak, L.R.; Hennig, R.; Huhn, C.; Borowiak, M.; Dolhain, R.J.E.M.; Deelder, A.M.; Rapp, E. & Wuhrer, M. (2010), Optimized Workflow for Preparation of APTS-Labeled N-Glycans Allowing High-Throughput Analysis of Human Plasma Glycomes using 48-Channel Multiplexed CGE-LIF, Journal of Proteome Research 9(12): 6655-6664.
- Schramm G, Hamilton JV, Balog CIA, Wuhrer M, Gronow A, Beckmann S, Wippersteg V, Grevelding CG, Goldmann T & Weber E (2009), Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs, Molecular and Biochemical Parasitology 166(1): 4-14.
- Huhn C, Selman MHJ, Ruhaak LR, Deelder AM & Wuhrer M (2009), IgG glycosylation analysis, Proteomics 9(4): 882-913.
- Ruhaak LR, Deelder AM & Wuhrer M (2009), Oligosaccharide analysis by graphitized carbon liquid chromatography-mass spectrometry, Analytical and Bioanalytical Chemistry 394(1): 163-174.
- Wuhrer M, Porcelijn L, Kapur R, Koeleman CAM, Deelder AM, de Haas M & Vidarsson G (2009), Regulated Glycosylation Patterns of IgG during Alloimmune Responses against Human Platelet Antigens, Journal of Proteome Research 8(2): 450-456.
- Wuhrer M, de Boer AR & Deelder AM (2009), STRUCTURAL GLYCOMICS USING HYDROPHILIC INTERACTION CHROMATOGRAPHY (HILIC) WITH MASS SPECTROMETRY, Mass Spectrometry Reviews 28(2): 192-206.
- Scherer HU, Wang J, Toes REM, van der Woude D, Koeleman CAM, de Boer AR, Huizinga TWJ, Deelder AM & Wuhrer M (2009), Immunoglobulin 1 (IgG1) Fc-glycosylation profiling of anti-citrullinated peptide antibodies from human serum, PROTEOMICS - Clinical Applications 3(1): 106-115.
- Heiskanen A, Hirvonen T, Salo H, Impola U, Olonen A, Laitinen A, Tiitinen S, Natunen S, Aitio O, Miller-Podraza H, Wuhrer M, Deelder AM, Natunen J, Laine J, Lehenkari P, Saarinen J, Satomaa T & Valmu L (2009), Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage, Glycoconjugate Journal 26(3): 367-384.
- Johswich, A.; Kraft, B.; Wuhrer, M.; Berger, M.; Deelder, A.M.; Hokke, C.H.; Gerardy-Schahn, R. & Bakker, H. (2009), Golgi targeting of Drosophila melanogaster beta 4GalNAcTB requires a DHHC protein family-related protein as a pilot, Journal of Cell Biology 184(1): 173-183.
- Wuhrer M, Koeleman CAM & Deelder AM (2009), Hexose Rearrangements upon Fragmentation of N-Glycopeptides and Reductively Aminated N-Glycans, Analytical Chemistry 81(11): 4422-4432.
- Wuhrer M, Koeleman CA & Deelder AM (2009), Two-dimensional HPLC separation with reverse-phase-nano-LC-MS/MS for the characterization of glycan pools after labeling with 2-aminobenzamide., Methods in Molecular Biology 534: 79-91.
- van de Geijn FE, Wuhrer M, Selman MHJ, Willemsen SP, de Man YA, Deelder AM, Hazes JMW & Dolhain RJEM (2009), Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study.
- de Geijn FEV, Wuhrer M, Willemsen SP, de Man YA, Deelder AM, Hazes JMW & Dolhain RJEM (2008), IgG galactosylation is associated with pregnancy-induced improvement of RA and the postpartum flare, Arthritis and Rheumatism 58(9).
- Ruhaak LR, Huhn C, Waterreus WJ, de Boer AR, Neususs C, Hokke CH, Deelder AM & Wuhrer M (2008), Hydrophilic interaction chromatography-based high-throughput sample preparation method for N-glycan analysis from total human plasma glycoproteins, Analytical Chemistry 80(15).
- Scherer HU, van der Woude D, Koeleman CA, de Boer AR, Huizinga TWJ, Deelder AM, Wuhrer M & Toes REM (2008), Glycan profiling of anti-citrullinated protein antibodies (ACPA) reveals profound differences in glycosylation between ACPA and serum, Arthritis and Rheumatism 58(9).
- Bakker H, Johswich A, Kraft B, Wuhrer M, Hokke CH & Gerardy-Schahn R (2008), Mechanism of Interaction between Drosophila beta 4GalNAcTB and the beta 4GalNAcTB Pilot Protein (GABPI), Glycobiology 18(11): 993-993.
- de Geijn FEV, Wuhrer M, de Man YA, Deelder AM, Colin E, Lubberts E, Hazes JMW & Dolhain RJEM (2008), Preliminary results on IgG glycosylation profiles in rheumatoid arthritis patients during pregnancy and postpartum, Annals of the Rheumatic Diseases 67.
- Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M & Bakker H (2008), Distinct contributions of beta 4GalNAcTA and beta 4GalNAcTB to Drosophila glycosphingolipid biosynthesis, Glycoconjugate Journal 25(2).
- van Alphen LB, Wuhrer M, Bleumink-Pluym NMC, Hensbergen PJ, Deelder AM & van Putten JPM (2008), A functional Campylobacter jejuni maf4 gene results in novel glycoforms on flagellin and altered autoagglutination behaviour, Microbiology 154.
- Niks EH, de Boer AR, Titulaer MJ, Jol-van der Zijde CM, Wuhrer M & Verschuuren JJGM (2008), Glycosylation of IgG in three autoimmune myasthenic syndromes, Journal of Neuroimmunology 203(2): 178-179.
- de Boer AR, Hokke CH, Deelder AM & Wuhrer M (2008), Serum antibody screening by surface plasmon resonance using a natural glycan microarray, Glycoconjugate Journal 25(1).
- Wuhrer M, Catalina MI, Deelder AM & Hokke CH (2007), Glycoproteomics based on tandem mass spectrometry of glycopeptides, Journal of Chromatography B 849(1-2).
- de Boer AR, Hokke CH, Deelder AM & Wuhrer M (2007), General microarray technique for immobilization and screening of natural glycans, Analytical Chemistry 79(21).
- Wuhrer M, Stam JC, van de Geijn FE, Koeleman CAM, Verrips CT, Dolhain RJEM, Hokke CH & Deelder AM (2007), Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum, Proteomics 7(22).
- Wuhrer M (2007), Glycosylation profiling in clinical proteomics: heading for glycan biomarkers, Expert Review of Proteomics 4(2).
- Catalina MI, Koeleman CAM, Deelder AM & Wuhrer M (2007), Electron transfer dissociation of N-glycopeptides: loss of the entire N-glycosylated asparagine side chain, Rapid Communications in Mass Spectrometry 21(6).
- Robijn MLM, Koeleman CAM, Wuhrer M, Royle L, Geyer R, Dwek RA, Rudd PM, Deelder AM & Hokke CH (2007), Targeted identification of a unique glycan epitope of Schistosoma mansoni egg antigens using a diagnostic antibody, Molecular and Biochemical Parasitology 151(2).
- Hokke CH, Deelder AM, Hoffmann KF & Wuhrer M (2007), Glycomics-driven discoveries in schistosome research, Experimental Parasitology 117(3).
- Rouwendal GJA, Wuhrer M, Florack DEA, Koeleman CAM, Deelder AM, Bakker H, Stoopen GM, van Die I, Helsper JPFG, Hokke CH & Bosch D (2007), Efficient introduction of a bisecting GlcNAc residue in tobacco N-glycans by expression of the gene encoding human N-acetylglucosaminyltransferase III, Glycobiology 17(3).
- Wuhrer M, Koeleman CAM, Deelder AM & Hokke CH (2006), Repeats of LacdiNAc and fucosylated LacdiNAc on N-glycans of the human parasite Schistosoma mansoni, FEBS Journal 273(2).
- Van Riet E, Wuhrer M, Wahyuni S, Retra K, Deelder AM, Tielens AGM, Van der Kleij D & Yazdanbakhsh M (2006), Antibody responses to Ascaris-derived proteins and glycolipids: the role of phosphorylcholine, Parasite Immunology 28(8).
- Wuhrer M, Koeleman CAM, Fitzpatrick JM, Hoffmann KF, Deelder AM & Hokke CH (2006), Gender-specific expression of complex-type N-glycans in schistosomes, Glycobiology 16(10).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2006), Mass spectrometry of proton adducts of fucosylated N-glycans: fucose transfer between antennae gives rise to misleading fragments, Rapid Communications in Mass Spectrometry 20(11).
- Wuhrer M, Balog CIA, Catalina MI, Jones FM, Schramm G, Haas H, Doenhoff MJ, Dunne DW, Deelder AM & Hokke CH (2006), IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans, FEBS Journal 273(10).
- Wuhrer M & Deelder AM (2006), Matrix-assisted laser desorption/ionization in-source decay combined with tandem time-of-flight mass spectrometry of permethylated oligosaccharides: targeted characterization of specific parts of the glycan structure, Rapid Communications in Mass Spectrometry 20(6).
- Wuhrer M & Deelder AM (2005), Negative-mode MALDI-TOF/TOF-MS of oligosaccharides labeled with 2-aminobenzamide, Analytical Chemistry 77(21).
- Bruggink C, Wuhrer M, Koeleman CAM, Barreto V, Liu Y, Pohl C, Ingendoh A, Hokke CH & Deelder AM (2005), Oligosaccharide analysis by capillary-scale high-pH anion-exchange chromatography with on-line ion-trap mass spectrometry, Journal of Chromatography B 829(1-2).
- Wuhrer M, Balog CIA, Koeleman CAM, Deelder AM & Hokke CH (2005), New features of site-specific horseradish peroxidase (HRP) glycosylation uncovered by nano-LC-MS with repeated ion-isolation/fragmentation cycles, BBA - General Subjects 1723(1-3).
- Robijn MLM, Wuhrer M, Kornelis D, Deelder AM, Geyer R & Hokke CH (2005), Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs, Parasitology 130.
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2005), Protein glycosylation analyzed by normal-phase nano-liquid chromatography-mass spectrometry of glycopeptides, Analytical Chemistry 77(3).
- Wuhrer M, Deelder AM & Hokke CH (2005), Protein glycosylation analysis by liquid chromatography-mass spectrometry, Journal of Chromatography B 825(2).
- Fitzsimmons CM, Schramm G, Jones FM, Chalmers IW, Hoffmann KE, Grevelding CG, Wuhrer M, Hokke CH, Haas H, Doenhoff MJ & Dunne DW (2005), Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs, Molecular and Biochemical Parasitology 144(1).
- Geyer H, Wuhrer M, Resemann A & Geyer R (2005), Identification and characterization of keyhole limpet hemocyanin N-glycans mediating cross-reactivity with Schistosoma mansoni, Journal of Biological Chemistry 280(49).
- Wuhrer M, Koeleman CAM, Deelder AM & Hokke CN (2004), Normal-phase nanoscale liquid chromatography - Mass spectrometry of underivatized oligosaccharides at low-femtomole sensitivity, Analytical Chemistry 76(3).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2004), Nano-scale liquid chromatography-mass spectrometry of 2-aminobenzamide-labeled oligosaccharides at low femtomole sensitivity, International Journal of Mass Spectrometry 232(1).
- Wuhrer M, Hokke CH & Deelder AM (2004), Glycopeptide analysis by matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry reveals novel features of horseradish peroxidase glycosylation, Rapid Communications in Mass Spectrometry 18(15).
- Wuhrer M, Robijn MLM, Koeleman CAM, Balog CIA, Geyer R, Deelder AM & Hokke CH (2004), A novel Gal(beta 1-4)Gal(beta 1-4)Fuc(alpha 1-6)-core modification attached to the proximal N-acetylglucosamine of keyhole limpet haemocyanin (KLH) N-glycans, Biochemical Journal 378.
- Member of ExCom European Journal of Immunology