Ko Willems van Dijk
Hoogleraar Genetica en systeembiologie van het metabool syndroom
- Naam
- Prof.dr.ir. J.A.P. Willems van Dijk
- Telefoon
- +31 71 518 9470
- kowvd@lumc.nl
- ORCID iD
- 0000-0002-2172-7394
Ko Willems van Dijk is hoogleraar bij de afdelingen Humane Genetica en Interne Geneeskunde, sectie Endocrinologie. Hij is voorzitter van de wetenschapscommissie van de afdeling Humane Genetica en lid van de executive board van de Nederlandse Epidemiologie van Obesitas (NEO) studie.
Meer informatie over Ko Willems van Dijk
Genetica en systeembiologie van het metabool syndroom
Het aantal mensen met overgewicht en obesitas in Nederland neemt nog steeds toe. Deze mensen hebben een aanzienlijk hogere kans op de ontwikkeling van type 2 diabetes, hart- en vaatziekten en bepaalde vormen van kanker. Deze ziekten hebben grote gevolgen voor de kwaliteit van leven van patiënten. Overgewicht is met name een risico op ziekte wanneer dit samengaat met andere risicofactoren zoals hoge bloeddruk of verhoogd bloedsuiker. Deze combinatie van risicofactoren wordt het metabool syndroom genoemd. Zowel erfelijke aanleg als de omgeving (voeding en levensstijl) spelen een belangrijke rol bij de ontwikkeling van het metabool syndroom en het risico op ziekte. Metabool syndroom is een aandoening waarbij het hele biologische systeem betrokken is. Dit vereist een brede “systeembiologische” aanpak om inzicht te krijgen in preventie en behandeling van metabool syndroom en daarmee samenhangende ziekten. Het onderzoek van Ko Willems van Dijk sluit aan bij meerdere specifieke vragen in de route “Gezondheidszorg- onderzoek, preventie en behandeling” van de Nationale Wetenschaps Agenda.
Wetenschappelijke carrière
Ko Willems van Dijk heeft zijn opleiding tot ingenieur in de Moleculaire Wetenschappen en Biotechnologie (1988) gedaan aan de Wageningen Universiteit en Research (WUR) in Wageningen. Aansluitend heeft hij zijn promotie onderzoek gedaan bij afdeling Pathologie van de Universiteit van Washington in Seattle, Verenigde Staten. De titel van zijn proefschrift (1992) is: “Chromosomal organization of the human VH locus and mapping of VH gene segments comprising the developmentally expressed repertoire”. Daarna is hij onderzoek gaan doen bij de afdeling Humane Genetica van het Leids Universitair Medisch Centrum. In 2012 is hij bij deze afdeling benoemd tot hoogleraar, met een gedeelde aanstelling bij de afdeling Geneeskunde, divisie Endocrinologie. Hij heeft meer dan 200 publicaties op zijn naam staan.
Zijn fascinatie is het samenspel tussen genen en omgeving bij het ontstaan van overgewicht en daarmee samenhangende ziektes. Het ontstaan van ziekte in de mens is de leidraad waarmee mechanismen en “pathways” in cel- en muismodellen onderzocht worden. Vice versa vormt inzicht in deze cel- en muismodellen de basis voor het ontwikkelen van nieuwe preventie- en behandelmethoden. De complexiteit van de interacties, waarbij per definitie meerdere organen en systemen betrokken zijn, vereist een geïntegreerde “systeembiologische” aanpak. Met behulp van zowel statistische als wiskundige methoden worden deze complexe interacties in kaart gebracht.
Betrokken onderzoeksthema's LUMC:
Prijzen en eervolle benoemingen
Voor zijn promotieonderzoek kreeg Ko Willems van Dijk een fellowship van de March of Dimes Birth Defects Foundation (1989). In 1994 werd hij benoemd als fellow op het Moleculaire Cardiologie Programma van de Nederlandse Hartstichting en in 2012 won hij samen met professor Eric Stroes van het AMC een Rembrandt Research Award.
Hoogleraar Genetica en systeembiologie van het metabool syndroom
- Faculteit Geneeskunde
- Divisie 4
- Humane Genetica
- Faquih, T.O.; Landstra, E.N.; Vlieg, A.V.; Aziz, N.A.; Li-Gao, R.; Mutsert, R. de; Rosendaal, F.R.; Noordam, R.; Heemst, D. van; Mook-Kanamori, D.O.; Dijk, K.W. van & Breteler, M.M.B. (2024), Per- and polyfluoroalkyl substances concentrations are associated with an unfavorable cardio-metabolic risk profile , Exposure and Health.
- Faquih, T.O.; Klinken, J.B. van; Li-Gao, R.; Noordam, R.; Heemst, D. van; Boone, S.; Sheridan, P.A.; Michelotti, G.; Lamb, H.; Mutsert, R. de; Rosendaal, F.R.; Vlieg, A.V.; Dijk, K.W. van & Mook-Kanamori, D.O. (2023), Hepatic triglyceride content is intricately associated with numerous metabolites and biochemical pathways, Liver International 43(7).
- Noordam, R.; Brochard, T.A.G.; Drewes, Y.M.; Gussekloo, J.; Mooijaart, S.P.; Dijk, K.W. van; Trompet, S.; Jukema, J.W. & Heemst, D. van (2023), Cardiovascular risk factors and major recurrent coronary events, Atherosclerosis 376: 19-25.
- Alshehri, T.; Mook-Kanamori, D.O.; Dijk, K.W. van; Dinga, R.; Penninx, B.W.J.H.; Rosendaal, F.R.; Cessie, S. le & Milaneschi, Y. (2023), Metabolomics dissection of depression heterogeneity and related cardiometabolic risk, Psychological Medicine 53(1): 248-257.
- Faquih, T.O.; Aziz, N.A.; Gardiner, S.L.; Li-Gao, R.; Mutsert, R. de; Milaneschi, Y.; Trompet, S.; Jukema, J.W.; Rosendaal, F.R.; Vlieg, A.V.; Dijk, K.W. van & Mook-Kanamori, D.O. (2023), Normal range CAG repeat size variations in the HTT gene are associated with an adverse lipoprotein profile partially mediated by body mass index, Human Molecular Genetics 32(10): 1741-1752.
- Faquih, T.O.; Klinken, J.B. van; Li-Gao, R.; Noordam, R.; Heemst, D. van; Boone, S.; Sheridan, P.A.; Michelotti, G.; Lamb, H.; Mutsert, R. de; Rosendaal, F.R.; Vlieg, A.V.; Dijk, K.W. van & Mook-Kanamori, D.O. (2023), Hepatic triglyceride content is intricately associated with numerous metabolites and biochemical pathways, Liver International 43(7).
- Graham, S.E.; Clarke, S.L.; Wu, K.H.H.; Kanoni, S.; Zajac, G.J.M.; Ramdas, S.; Surakka, I.; Ntalla, I.; Vedantam, S.; Winkler, T.W.; Locke, A.E.; Marouli, E.; Hwang, M.Y.; Han, S.; Narita, A.; Choudhury, A.; Bentley, A.R.; Ekoru, K.; Verma, A.; Trivedi, B.; Martin, H.C.; Hunt, K.A.; Hui, Q.; Klarin, D.; Zhu, X.; Thorleifsson, G.; Helgadottir, A.; Gudbjartsson, D.F.; Holm, H.; Olafsson, I.; Akiyama, M.; Sakaue, S.; Terao, C.; Kanai, M.; Zhou, W.; Brumpton, B.M.; Rasheed, H.; Ruotsalainen, S.E.; Havulinna, A.S.; Veturi, Y.; Feng, Q.P.; Rosenthal, E.A.; Lingren, T.; Pacheco, J.A.; Pendergrass, S.A.; Haessler, J.; Giulianini, F.; Bradford, Y.; Miller, J.E.; Campbell, A.; Lin, K.; Millwood, I.Y.; Hindy, G.; Rasheed, A.; Faul, J.D.; Zhao, W.; Weir, D.R.; Turman, C.; Huang, H.Y.; Graff, M.; Mahajan, A.; Brown, M.R.; Zhang, W.H.; Yu, K.T.; Schmidt, E.M.; Pandit, A.; Gustafsson, S.; Yin, X.Y.; Luan, J.A.; Zhao, J.H.; Matsuda, F.; Jang, H.M.; Yoon, K.; Medina-Gomez, C.; Pitsillides, A.; Hottenga, J.J.; Willemsen, G.; Wood, A.R.; Ji, Y.J.; Gao, Z.S.; Haworth, S.; Mitchell, R.E.; Chai, J.F.; Aadahl, M.; Yao, J.; Manichaikul, A.; Warren, H.R.; Ramirez, J.; Bork-Jensen, J.; Kårhus, L.L.; Goel, A.; Sabater-Lleal, M.; Noordam, R.; Sidore, C.; Fiorillo, E.; McDaid, A.F.; Marques-Vidal, P.; Wielscher, M.; Trompet, S.; Sattar, N.; Mollehave, L.T.; Thuesen, B.H.; Munz, M.; Zeng, L.Y.; Huang, J.F.; Yang, B.; Poveda, A.; Kurbasic, A.; Lamina, C.; Forer, L.; Scholz, M.; Galesloot, T.E.; Bradfield, J.P.; Daw, E.W.; Zmuda, J.M.; Mitchell, J.S.; Fuchsberger, C.; Christensen, H.; Brody, J.A.; Feitosa, M.F.; Wojczynski, M.K.; Preuss, M.; Mangino, M.; Christofidou, P.; Verweij, N.; Benjamins, J.W.; Engmann, J.; Kember, R.L.; Slieker, R.C.; , K.S. lo; Zilhao, N.R.; , P. le; Kleber, M.E.; Delgado, G.E.; Huo, S.F.; Ikeda, D.D.; Iha, H.; Yang, J.; Liu, J.; Leonard, H.L.; Marten, J.; Schmidt, B.; Arendt, M.; Smyth, L.J.; Cañadas-Garre, M.; Wang, C.L.; Nakatochi, M.; Wong, A.; Hutri-Kähönen, N.; Sim, X.; Xia, R.; Huerta-Chagoya, A.; Fernandez-Lopez, J.C.; Lyssenko, V.; Ahmed, M.; Jackson, A.U.; Yousri, N.A.; Irvin, M.R.; Oldmeadow, C.; Kim, H.N.; Ryu, S.; Timmers, P.R.H.J.; Arbeeva, L.; Dorajoo, R.; Lange, L.A.; Chai, X.R.; Prasad, G.; Lorés-Motta, L.; Pauper, M.; Long, J.R.; Li, X.H.; Theusch, E.; Takeuchi, F.; Spracklen, C.N.; Loukola, A.; Bollepalli, S.; Warner, S.C.; Wang, Y.X.; Wei, W.B.; Nutile, T.; Ruggiero, D.; Sung, Y.J.; Hung, Y.J.; Chen, S.F.; Liu, F.C.; Yang, J.Y.; Kentistou, K.A.; Gorski, M.; Brumat, M.; Meidtner, K.; Bielak, L.F.; Smith, J.A.; Hebbar, P.; Farmaki, A.E.; Hofer, E.; Lin, M.X.; Xue, C.; Zhang, J.F.; Concas, M.P.; Vaccargiu, S.; Most, P.J. van der; Pitkänen, N.; Cade, B.E.; Lee, J.; Laan, S.W. van der; Chitrala, K.N.; Weiss, S.; Zimmermann, M.E.; Lee, J.Y.; Choi, H.S.; Nethander, M.; Freitag-Wolf, S.; Southam, L.; Rayner, N.W.; Wang, C.A.; Lin, S.Y.; Wang, J.S.; Couture, C.; Lyytikäinen, L.P.; Nikus, K.; Cuellar-Partida, G.; Vestergaard, H.; Hildalgo, B.; Giannakopoulou, O.; Cai, Q.Y.; Obura, M.O.; Setten, J. van; Li, X.Y.; Schwander, K.; Terzikhan, N.; Shin, J.H.; Jackson, R.D.; Reiner, A.P.; Martin, L.W.; Chen, Z.M.; Li, L.M.; Highland, H.M.; Young, K.L.; Kawaguchi, T.; Thiery, J.; Bis, J.C.; Nadkarni, G.N.; Launer, L.J.; Li, H.X.; Nalls, M.A.; Raitakari, O.T.; Ichihara, S.; Wild, S.H.; Nelson, C.P.; Campbell, H.; Jäger, S.; Nabika, T.; Al-Mulla, F.; Niinikoski, H.; Braund, P.S.; Kolcic, I.; Kovacs, P.; Giardoglou, T.; Katsuya, T.; Bhatti, K.F.; Kleijn, D. de; Borst, G.J. de; Kim, E.K.; Adams, H.H.H.; Ikram, M.A.; Zhu, X.F.; Asselbergs, F.W.; Kraaijeveld, A.O.; Beulens, J.W.J.; Shu, X.O.; Rallidis, L.S.; Pedersen, O.; Hansen, T.; Mitchell, P.; Hewitt, A.W.; Kähönen, M.; Pérusse, L.; Bouchard, C.; Tönjes, A.; Chen, Y.D.I.; Pennell, C.E.; Mori, T.A.; Lieb, W.; Franke, A.; Ohlsson, C.; Mellström, D.; Cho, Y.S.; Lee, H.; Yuan, J.M.; Koh, W.P.; Rhee, S.Y.; Woo, J.T.; Heid, I.M. & Stark, K. (2023), The power of genetic diversity in genome-wide association studies of lipids (vol 600, pg 675, 2021), Nature.
- Ao, L.J.; Dijk, K.W. van; Heemst, D. van & Noordam, R. (2023), Differential and sex- and age-specific risks of cardiometabolic diseases with unrelated metabolic syndrome dimensions, Obesity 31(7).
- Li, Z.; Zhou, E.C.; Liu, C.; Wicks, H.; Yildiz, S.; Razack, F.; Ying, Z.X.; Kooijman, S.; Koonen, D.P.Y.; Heijink, M.; Kostidis, S.; Giera, M.; Sanders, I.M.J.G.; Kuijper, E.J.; Smits, W.K.; Dijk, K.W. van; Rensen, P.C.N. & Wang, Y.A. (2023), Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4, JCI Insight 8(4).
- Li-Gao, R.; Lu, C.; Hughes, D.A.; Klinken, J.B. van; Mutsert, R. de; Rosendaal, F.R.; Timpson, N.J.; Mook-Kanamori, D.O.; Goeman, J.J.; Putter, H. & Dijk, K.W. van (2023), The associations between metabolomic responses to a liquid mixed meal and incidence of type 2 diabetes: Are there novel biomarkers beyond glucose and triglyceride response?, Diabetologia 66(SUPPL 1): S14-S14.
- Faquih, T.O.; Aziz, N.A.; Gardiner, S.L.; Li-Gao, R.; Mutsert, R. de; Milaneschi, Y.; Trompet, S.; Jukema, J.W.; Rosendaal, F.R.; Vlieg, A.V.; Dijk, K.W. van & Mook-Kanamori, D.O. (2023), Normal range CAG repeat size variations in the HTT gene are associated with an adverse lipoprotein profile partially mediated by body mass index, Human Molecular Genetics 32(10): 1741-1752.
- Martens, L.G.; Hamersveld, D. van; Cessie, S. le; Dijk, K.W. van; Heemst, D. van & Noordam, R. (2023), The impact of sociodemographic status on the association of classical cardiovascular risk factors with coronary artery disease, Journal of Clinical Epidemiology 162: 56-62.
- Christen, T.; Mutsert, R. de; Smit, R.A.; Dijk, K.W. van; Lamb, H.J.; Rosendaal, F.R.; Jukema, J.W. & Trompet, S. (2023), The association between leptin and subclinical cardiovascular disease explained by body fat, Nutrition, Metabolism & Cardiovascular Diseases 33(5): 1077-1086.
- Winsvold, B.S.; Harder, A.V.E.; Ran, C.; Chalmer, M.A.; Dalmasso, M.C.; Ferkingstad, E.; Tripathi, K.P.; Bacchelli, E.; Borte, S.; Fourier, C.; Petersen, A.S.; Vijfhuizen, L.S.; Magnusson, S.H.; O'Connor, E.; Bjornsdottir, G.; Häppölä, P.; Wang, Y.F.; Callesen, I.; Kelderman, T.; Gallardo, V.J.; Boer, I. de; Olofsgård, F.J.; Heinze, K.; Lund, N.; Thomas, L.F.; Hsu, C.L.; Pirinen, M.; Hautakangas, H.; Ribasés, M.; Guerzoni, S.; Sivakumar, P.; Yip, J.; Heinze, A.; Küçükali, F.; Ostrowski, S.R.; Pedersen, O.B.; Kristoffersen, E.S.; Martinsen, A.E.; Artigas, M.S.; Lagrata, S.; Cainazzo, M.M.; Adebimpe, J.; Quinn, O.; Göbel, C.; Cirkel, A.; Volk, A.E.; Heilmann-Heimbach, S.; Skogholt, A.H.; Gabrielsen, M.E.; Wilbrink, L.A.; Danno, D.; Mehta, D.; Guobjartsson, D.F.; Rosendaal, F.R.; Dijk, K.W. van; Fronczek, R.; Wagner, M.; Scherer, M.; Göbel, H.; Sleegers, K.; Sveinsson, O.A.; Pani, L.; Zoli, M.; Ramos-Quiroga, J.A.; Dardiotis, E.; Steinberg, A.; Riedel-Heller, S.; Sjöstrand, C.; Thorgeirsson, T.E.; Stefansson, H.; Southgate, L.; Trembath, R.C.; Vandrovcova, J.; Noordam, R.; Paemeleire, K.; Stefansson, K.; Fann, C.S.J.; Waldenlind, E.; Tronvik, E.; Jensen, R.H.; Chen, S.P.; Houlden, H.; Terwindt, G.M.; Kubisch, C.; Maestrini, E.; Vikelis, M.; Pozo-Rosich, P.; Belin, A.C.; Matharu, M.; Maagdenberg, A.M.J.M. van den; Hansen, T.F.; Ramirez, A.; Zwart, J.A.; HUNT All Headache; Int Headache Genetics Consortium; Genomic Consortium & Int Consortium Cluster Headache (2023), Cluster headache genomewide association study and meta-analysis identifies eight loci and implicates smoking as causal risk factor, Annals of Neurology 94(4).
- Wang, W.Y.; Battini, V.; Carnovale, C.; Noordam, R.; Dijk, K.W. van; Kragholm, K.H.; Heemst, D. van; Soeorg, H. & Sessa, M. (2023), A novel approach for pharmacological substantiation of safety signals using plasma concentrations of medication and administrative/healthcare databases, Pharmacological Research 193.
- Luo, J.; Noordam, R.; Jukema, J.W.; Dijk, K.W. van; Hägg, S.; Grassmann, F.; Cessie, S. le & Heemst, D. van (2023), Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases, Cardiovascular Research 119(4): 998-1007.
- Ao, L.; Heemst, D. van; Jukema, J.W.; Rensen, P.; Dijk, K.W. van & Noordam, R. (2023), EVIDENCE SUPPORTING A CAUSAL RELATIONSHIP BETWEEN AN APOB-INDEPENDENT 1H-NMR METABOLOMICS PROFILE AND ATHEROSCLEROTIC CARDIOVASCULAR DISEASE, Atherosclerosis 379.
- Paalvast, Y.; Zhou, E.; Rozendaal, Y.J.W.; Wang, Y.N.; Gerding, A.; Dijk, T.H. van; Boer, J.F. de; Rensen, P.C.N.; Dijk, K.W. van; Kuivenhoven, J.A.; Bakker, B.M.; Riel, N.A.W. van & Groen, A.K. (2022), A systems analysis of phenotype heterogeneity in APOE*3Leiden.CETP mice induced by long-term high-fat high-cholesterol diet feeding, Nutrients 14(22).
- Hautakangas, H.; Winsvold, B.S.; Ruotsalainen, S.E.; Bjornsdottir, G.; Harder, A.V.E.; Kogelman, L.J.A.; Thomas, L.F.; Noordam, R.; Benner, C.; Gormley, P.; Artto, V.; Banasik, K.; Bjornsdottir, A.; Boomsma, D.I.; Brumpton, B.; Burgdorf, K.S.; Buring, J.E.; Chalmer, M.A.; Boer, I. de; Dichgans, M.; Erikstrup, C.; Farkkila, M.; Garbrielsen, M.E.; Ghanbari, M.; Hagen, K.; Happola, P.; Hottenga, J.J.; Hrafnsdottir, M.G.; Hveem, K.; Johnsen, M.B.; Kahonen, M.; Kristoffersen, E.S.; Kurth, T.; Lehtimaki, T.; Lighart, L.; Magnusson, S.H.; Malik, R.; Pedersen, O.B.; Pelzer, N.; Penninx, B.W.J.H.; Ran, C.; Ridker, P.M.; Rosendaal, F.R.; Sigurdardottir, G.R.; Skogholt, A.H.; Sveinsson, O.A.; Thorgeirsson, T.E.; Ullum, H.; Vijfhuizen, L.S.; Widen, E.; Dijk, K.W. van; Aromaa, A.; Belin, A.C.; Freilinger, T.; Ikram, M.A.; Jarvelin, M.R.; Raitakari, O.T.; Terwindt, G.M.; Kallela, M.; Wessman, M.; Olesen, J.; Chasman, D.I.; Nyholt, D.R.; Stefansson, H.; Stefansson, K.; Maagdenberg, A.M.J.M. van den; Hansen, T.F.; Ripatti, S.; Zwart, J.A.; Palotie, A.; Pirinen, M.; Int Headache Genetics Consortium; HUNT All-in Headache & Danish Blood Donor Study Genomic C (2022), Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles, Nature Genetics 54.
- Liu, J.; Vries, P.S. de; Greco, M.F. del; Johansson, A.; Schraut, K.E.; Hayward, C.; Dijk, K.W. van; Franco, O.H.; Hicks, A.A.; Vitart, V.; Rudan, I.; Campbell, H.; Polasek, O.; Pramstaller, P.P.; Wilson, J.F.; Gyllensten, U.; Duijn, C.M. van; Dehghan, A. & Demirkan, A. (2022), A multi-omics study of circulating phospholipid markers of blood pressure, Scientific Reports 12(1).
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