Ingrid Meulenbelt
Hoogleraar moleculaire biologie van artrose
- Naam
- Prof.dr. I. Meulenbelt
- Telefoon
- +31 71 526 9734
- i.meulenbelt@lumc.nl
- ORCID iD
- 0000-0001-7786-7081
Ingrid Meulenbelt is professor in de moleculaire biologie van artrose en is hoofd van de Artrose-onderzoeksgroep binnen de sectie Moleculaire Epidemiologie van de afdeling Biomedical Data Sciences. Ze is vice-voorzitter van de LUMC VENI commissie en lid van het operationeel onderwijs overleg van de master biomedische wetenschappen (OOO MaBMS). In 2016 heeft Meulenbelt een NWO-VICI subsidie gekregen om de diversiteit van de onderliggende moleculaire artrose processen in kaart te brengen. Meulenbelt zit in organiserend comité van het prestigieuze internationale artrose congres; OsteoArthritis Society International (OARSI) als voorzitter van de abstract (2019) en het programma (2020).
Meer informatie over Ingrid Meulenbelt
Ingrid Meulenbelt is professor in de moleculaire biologie van artrose en is hoofd van de Artrose-onderzoeksgroep binnen de sectie Moleculaire Epidemiologie van de afdeling Biomedical Data Sciences. Ze is vice-voorzitter van de LUMC VENI commissie en lid van het operationeel onderwijs overleg van de master biomedische wetenschappen (OOO MaBMS). In 2016 heeft Meulenbelt een NWO-VICI subsidie gekregen om de diversiteit van de onderliggende moleculaire artrose processen in kaart te brengen. Meulenbelt zit in organiserend comité van het prestigieuze internationale artrose congres; OsteoArthritis Society International (OARSI) als voorzitter van de abstract (2019) en het programma (2020).
Moleculaire biologie van artrose
De leerstoel van Meulenbelt richt zich op de moleculaire biologie van artrose. Artrose is een invaliderende gewrichtsaandoening waar 1,2 miljoen mensen in Nederland mee kampen, maar waarvoor nog geen werkend medicijn voorhanden is. Patiënten zijn daarom vaak jarenlang afhankelijk van fysiotherapie en/of palliatieve zorg, wat een hoge sociale en economische ziektelast veroorzaakt.
Uitgangspunt van de leerstoel van Meulenbelt is dat de ontwikkeling van effectieve behandeling voor artrose ernstig wordt gehinderd doordat het ziekteproces aanzienlijk verschilt tussen patiënten.
Om de diversiteit in het artroseproces te ontrafelen richt Meulenbelt zich allereest op het in kaart brengen van de karakteristieke verschillen op moleculair niveau, tussen de ziekteprocessen die plaatsvinden in bot en kraakbeen van patiënten die een gewrichtsvervangende operatie ondergaan vanwege artrose. Op basis van deze karakteristieke moleculaire patronen (genetica, transcriptie, en epigenetica) wordt vervolgens een menselijk model systeem van artrose, een artrose-gewricht-op-chip, ontwikkeld. Hiermee kan de biologische basis van deze verschillende ziekteprocessen in bot en kraakbeen verder worden bestudeerd. Door gebruik te maken van stamcellen (iPSCs) die aangezet worden tot het maken van kwalitatief hoogwaardig bot en kraakbeen ontstaat een reproduceerbaar model. Met deze methodologie-ontwikkeling draagt het onderzoek ook bij aan de regeneratieve geneeskunde binnen het artroseveld.
Risicofactoren van artrose in de mens zoals erfelijkheid en mechanische belasting kunnen vervolgens in het model toegepast worden om het artroseproces in gang te zetten. Met het model kan ook worden gezocht naar nieuwe aangrijpingspunten voor effectieve artrose-therapie-op-maat. Om de translatie naar de kliniek mogelijk te maken worden moleculaire signaalmoleculen in bloed opgespoord die het aanwezige ziekteproces in weefsels kunnen rapporteren. Als zodanig adresseert de leerstoel meerdere vragen uit de Nationale Wetenschapsagenda en draagt het bij aan de belangrijke maatschappelijke uitdaging die artrose heet.
Wetenschappelijke carrière
Professor Ingrid Meulenbelt rondde in 1990 de studie Medische Biologie cum laude af aan de Universiteit van Amsterdam. Na 2 jaar als onderzoeker te hebben gewerkt bij Medscand Ingeny startte zij in 1992 haar promotieonderzoek aan de Universiteit in Leiden getiteld ‘Genetische risicofactoren van artrose’, die zij in 1997 afrondde. Als gedetacheerde postdoc onderzoeker bij TNO Preventie en Gezondheid vervolgende ze haar artrose-onderzoek en zette zij samen met de afdeling Reumatologie de landmark-studie Genetica Artrose en Progressie (GARP) op. In 2000 maakte zij als universitair docent de overstap naar het Leids Universitair Centrum (LUMC) en startte zij haar eigen onderzoekslijn met betrekking tot functioneel genomisch artrose-onderzoek. In 2008, nu als universitair hoofddocent, startte zij een tweede landmark-studie genaamd Research in Articulair Artrose Kraakbeen (RAAK), ditmaal met de afdeling Orthopaedi. De RAAK-studie vormt nog steeds het fundament van het huidige artrose-onderzoek in de groep van Meulenbelt. In 2016 ontving zij een prestigieuze VICI-beurs van NWO en mede als gevolg daarvan werd zij in 2017 benoemd tot hoogleraar in de Moleculaire Biologie van Artrose bij het LUMC. Haar inauguratie vond plaats op 19-01-2018 en was getiteld: ‘Artrose van diversiteit in moleculaire paden tot effectieve therapie op maat’.
Prijzen en eervolle benoemingen
- Lid organiserend comité (abstract voorzitter in 2019; programma voorzitter 2020) van het jaarlijkse internationale artrose-congres; OsteoArthritis Society International (OARSI). OARSI is de grootste internationale vereniging van artsen en onderzoekers die zich inzetten voor de ontwikkeling van preventie en behandeling van artrose door de promotie en presentatie van onderzoek, onderwijs en de wereldwijde verspreiding van nieuwe kennis.
- Lid van de board of directors van de OARSI van 2009 tot 2016.
Hoogleraar moleculaire biologie van artrose
- Faculteit Geneeskunde
- Divisie 4
- Biomedical Data Sciences
- Johnbosco, C. Leijten & J. (2024), TIMELY MODIFICATION OF MICROENVIRONMENT STIFFNESS IMPROVES CHONDROGENESIS OF SINGLE CELL HIMSCS .
- Bloks, N.G.C.; Dicks, A.; Harissa, Z.; Nelissen, R.G.H.H.; Hajmousa, G.; Ramos, Y.F.M.; Almeida, R.C. de; Guilak, F. & Meulenbelt, I. (2024), Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids, Clinical Epigenetics 16(1).
- Johnbosco, C. Leijten & J. (2024), Timely modification of microenvironment stiffness improves chondrogenesis of single cell hiMSCs.
- Korthagen, N.M.; Houtman, E.; Boone,; Almeida, R.C. de; Sivasubramaniyan, K.; Mahdad, R.; Nelissen, R.G.H.H.; Ramos, Y.F.M.; Tessari, M.A. & Meulenbelt, (2024), Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model, Arthritis Research and Therapy 26(1).
- Johnbosco, C. Leijten & J. (2024), Timely Modification of Microenvironment Stiffness Improves Chondrogenesis of Single Cell hiMSCs.
- Govindaraj, K.; Kannan, S.; Almeida, R.C. de; Klomp, L.J.; Karperien, M.; Meulenbelt, I. & Post, J.N. (2024), Dissecting SOX9 dynamics reveals its differential regulation in osteoarthritis, Journal of Cellular Physiology.
- Sterenborg, R.B.T.M.; Steinbrenner, I.; Li, Y.; Bujnis, M.N.; Naito, T.; Marouli, E.; Galesloot, T.E.; Babajide, O.; Andreasen, L.; Astrup, A.; Asvold, B.O.; Bandinelli, S.; Beekman, M.; Beilby, J.P.; Bork-Jensen, J.; Boutin, T.; Brody, J.A.; Brown, S.J.; Brumpton, B.; Campbell, P.J.; Cappola, A.R.; Ceresini, G.; Chaker, L.; Chasman, D.; Concas, M.P.; Almeida, R.C. de; Cross, S.M.; Cucca, F.; Deary, I.J.; Kjaergaard, A.D.; Tcheugui, J.B.E.; Ellervik, C.; Eriksson, J.G.; Ferrucci, L.; Freudenberg, J.; Fuchsberger, C.; Gieger, C.; Giulianini, F.; Gögele, M.; Graham, S.E.; Grarup, N.; Gunjaca, I.; Hansen, T.; Harding, B.N.; Harris, S.E.; Haunso, S.; Hayward, C.; Hui, J.; Ittermann, T.; Jukema, J.W.; Kajantie, E.; Kanters, J.K.; Kårhus, L.L.; Kiemeney, L.A.L.M.; Kloppenburg, M.; Kühnel, B.; Lahti, J.; Langenberg, C.; Lapauw, B.; Leese, G.; Li, S.; Liewald, D.C.M.; Linneberg, A.; Lominchar, J.V.T.; Luan, J.A.; Martin, N.G.; Matana, A.; Meima, M.E.; Meitinger, T.; Meulenbelt, I.; Mitchell, B.D.; Mollehave, L.T.; Mora, S.; Naitza, S.; Nauck, M.; Netea-Maier, R.T.; Noordam, R.; Nursyifa, C.; Okada, Y.; Onano, S.; Papadopoulou, A.; Palmer, C.N.A.; Pattaro, C.; Pedersen, O.; Peters, A.; Pietzner, M.; Polasek, O.; Pramstaller, P.P.; Psaty, B.M.; Punda, A.; Ray, D.; Redmond, P.; Richards, J.B.; Ridker, P.M.; Russ, T.C.; Ryan, K.A.; Olesen, M.S.; Schultheiss, U.T.; Selvin, E.; Siddiqui, M.K.; Sidore, C.; Slagboom, P.E.; Sorensen, T.I.A.; Soto-Pedre, E.; Spector, T.D.; Spedicati, B.; Srinivasan, S.; Starr, J.M.; Stott, D.J.; Tanaka, T.; Torlak, V.; Trompet, S.; Tuhkanen, J.; Uitterlinden, A.G.; Akker, E.B. van den; Eynde, T. van den; Klauw, M.M. van der; Heemst, D. van; Verroken, C.; Visser, W.E.; Vojinovic, D.; Völzke, H.; Waldenberger, M.; Walsh, J.P.; Wareham, N.J.; Weiss, S.; Willer, C.J.; Wilson, S.G.; Wolffenbuttel, B.H.R.; Wouters, H.J.C.M.; Wright, M.J.; Yang, Q.; Zemunik, T.; Zhou, W.; Zhu, G.; Zöllner, S.; Smit, J.W.A.; Peeters, R.P.; Köttgen, A.; Teumer, A.; Medici, M.; Ghs DiscovEHR & Regeneron Genetics Ctr (2024), Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications, Nature Communications 15(1).
- Timmermans, R.G.M.; Blom, A.B.; Nelissen, R.G.H.H.; Broekhuis, D.; Kraan, P.M. van der; Meulenbelt, I.; Bosch, M.H.J. van den & Ramos, Y.F.M. (2023), Mechanical stress and inflammation have opposite effects on Wnt signaling in human chondrocytes, Journal of Orthopaedic Research.
- Meteling, M.; Loo, B. van; Suurmond, C.A.; Kern, M.; Govindaraj, K.; Meulenbelt, I.; Ramos, Y.F.M.; Teixeira, L.S.M. & Leijten, J. (2023), 3D tissue formation increases intracellular macromolecular crowding which programs the metabolism and lineage commitment of stem cells, Tissue Engineering Part A 29(13-14).
- Boone, I.; Tuerlings, M.; Almeida, R.C. de; Lehmann, J.; Ramos, Y.; Nelissen, R.; Slagboom, E.; Keizer, P. de & Meulenbelt, I. (2023), Identified senescence endotypes in aged cartilage are reflected in the blood metabolome, Geroscience 46.
- Hoolwerff, M. van; Nickel, M.; Ramos, Y. & Meulenbelt, I. (2023), HIGH-IMPACT FN1 MUTATION ABROGATES RESPONSE OF CHONDROCYTES TO HYPER-PHYSIOLOGICAL LOADING, Osteoarthritis and Cartilage 31: S335-S336.
- Nickel, M.; Hoolwerff, M. van; Johnbosco, C.; Leijten, J.; Meulenbelt, I. & Ramos, Y. (2023), Improving analysis of human induced mesenchymal stromal cells during chondrogenic differentiation through encapsulation in single cell microgels, Tissue Engineering Part A 29(13-14).
- Tuerlings, M.; Boone, I.; Suchiman, E.; Lakenberg, N.; Wal, R. van der; Nelissen, R.; Ramos, Y.; Almeida, R.C. de & Meulenbelt, I. (2023), IDENTIFICATION OF CIRCULATING MICRO RNAS TO PREDICT OSTEOARTHRITIS MOLECULAR ENDOTYPES BY WHOLE TRANSCRIPTOMIC DATA INTEGRATION AND MATCHING DRUGGABLE TARGETS, Osteoarthritis and Cartilage 31: S108-S109.
- Boone, I.; Berg, J.J. van den; Eirin, M.V.; Tuerlings, M.; Houtman, E.; Demaria, M. & Meulenbelt, I. (2023), MODELLING SENESCENCE IN OSTEOARTHRITIS: COMBINING IRRADIATION AND MECHANICAL LOADING IN HUMAN OSTEOCHONDRAL EXPLANTS, Osteoarthritis and Cartilage 31: S333-S334.
- Tuerlings, M.; Janssen, G.M.C.; Boone, I.; Hoolwerff, M. van; Ruiz, A.R.; Houtman, E.; Suchiman, H.E.D.; Wal, R.J.P. van der; Nelissen, R.G.H.H.; Almeida, R.C. de; Veelen, P.A. van; Ramos, Y.F.M. & Meulenbelt, I. (2023), WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes, Osteoarthritis and Cartilage 31(1): 39-48.
- Assi, R.; Cherifi, C.; Cornelis, F.M.F.; Zhou, Q.F.; Storms, L.; Pazmino, S.; Almeida, R.C. de; Meulenbelt, I.; Lories, R.J. & Monteagudo, S. (2023), Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis, Annals of the Rheumatic Diseases.
- Timmermans, R.G.; Bloks, N.G.; Lent, P.L. van; Kraan, P.M. van der; Nelissen, R.G.; Blom, A.B.; Meulenbelt, I.; Bosch, M.H. van den & Ramos, Y.F. (2022), OPPOSITE EFFECTS OF HYPER-PHYSIOLOGICAL MECHANICAL STRESS AND INFLAMMATION ON WNT SIGNALING IN HUMAN CHONDROCYTE NEO-CARTILAGE PELLETS, Osteoarthritis and Cartilage 30: S165-S165.
- Ramos, Y.F.M.; Tertel, T.; Shaw, G.; Staubach, S.; Almeida, R.C. de; Suchiman, E.; Kuipers, T.B.; Mei, H.L.; Barry, F.; Murphy, M.; Giebel, B. & Meulenbelt, I. (2022), Characterizing the secretome of licensed hiPSC-derived MSCs, Stem Cell Research and Therapy 13(1).
- Ramos, Y.F.M.; Meulenbelt, I. & Meijer, J.H. (2022), Clock genes for joint health: if we could turn back time, Rheumatology 61(1): 3-5.
- Ruiz, A.R.; Tuerlings, M.; , A. das; Almeida, R.C. de; Suchiman, H.E.D.; Nelissen, R.G.H.H.; Ramos, Y.F.M. & Meulenbelt, I. (2022), The role of TNFRSF11B in development of osteoarthritic cartilage, Rheumatology 61(2): 856-864.
- Boone, I.; Tuerlings, M.; Almeida, R.C. de; Lehmann, J.; Nelissen, R.G.; Keizer, P.L. de & Meulenbelt, I. (2022), BLOOD MICRO-RNAS DELINEATING SENESCENCE PHENOTYPES IN OSTEOARTHRITIS, Osteoarthritis and Cartilage 30: S130-S130.
- Hall, M.; Esch, M. van der; Hinman, R.S.; Peat, G.; Zwart, A. de; Quicke, J.G.; Runhaar, J.; Knoop, J.; Leeden, M. van der; Rooij, M. de; Meulenbelt, I.; Vlieland, T.V.; Lems, W.F.; Holden, M.A.; Foster, N.E. & Bennell, K.L. (2022), How does hip osteoarthritis differ from knee osteoarthritis?, Osteoarthritis and Cartilage 30(1): 32-41.
- Watson, H.J.; Thornton, L.M.; Yilmaz, Z.; Baker, J.H.; Coleman, J.R.I.; Adan, R.A.H.; Alfredsson, L.; Andreassen, O.A.; Ask, H.; Berrettini, W.H.; Boehnke, M.; Boehm, I.; Boni, C.; Buehren, K.; Bulant, J.; Burghardt, R.; Chang, X.; Cichon, S.; Cone, R.D.; Courtet, P.; Crow, S.; Crowley, J.J.; Danner, U.N.; Zwaan, M. de; Dedoussis, G.; DeSocio, J.E.; Dick, D.M.; Dikeos, D.; Dina, C.; Djurovic, S.; Dmitrzak-Weglarz, M.; Docampo-Martinez, E.; Duriez, P.; Egberts, K.; Ehrlich, S.; Eriksson, J.G.; Escaramís, G.; Esko, T.; Estivill, X.; Farmer, A.; Fernández-Aranda, F.; Fichter, M.M.; Föcker, M.; Foretova, L.; Forstner, A.J.; Frei, O.; Gallinger, S.; Giegling, I.; Giuranna, J.; Gonidakis, F.; Gorwood, P.; Gratacòs, M.; Guillaume, S.; Guo, Y.R.; Hakonarson, H.; Hauser, J.; Havdahl, A.; Hebebrand, J.; Helder, S.G.; Herms, S.; Herpertz-Dahlmann, B.; Herzog, W.; Hinney, A.; Hübel, C.; Hudson, J.I.; Imgart, H.; Jamain, S.; Janout, V.; Jiménez-Murcia, S.; Jones, I.R.; Julià, A.; Kalsi, G.; Kaminská, D.; Kaprio, J.; Karhunen, L.; Kas, M.J.H.; Keel, P.K.; Kennedy, J.L.; Keski-Rahkonen, A.; Kiezebrink, K.; Klareskog, L.; Klump, K.L.; Knudsen, G.P.S.; Via, M.C. la; Hellard, S. le; Leboyer, M.; Li, D.; Lilenfeld, L.; Lin, B.C.; Lissowska, J.; Luykx, J.; Magistretti, P.; Maj, M.; Marsal, S.; Marshall, C.R.; Mattingsdal, M.; Meulenbelt, I.; Micali, N.; Mitchell, K.S.; Monteleone, A.M.; Monteleone, P.; Myers, R.; Navratilova, M.; Ntalla, I.; O'Toole, J.K.; Ophoff, R.A.; Padyukov, L.; Pantel, J.; Papezová, H.; Pinto, D.; Raevuori, A.; Ramoz, N.; Reichborn-Kjennerud, T.; Ricca, V.; Ripatti, S.; Ripke, S.; Ritschel, F.; Roberts, M.; Rotondo, A.; Rujescu, D.; Rybakowski, F.; Scherag, A.; Scherer, S.W.; Schmidt, U.; Scott, L.J.; Seitz, J.; Silén, Y.; Slachtová, L.; Slagboom, P.E.; Slof-Op 't Landt, C.T.; Slopien, A.; Sorbi, S.; Swiatkowska, B.; Tortorella, A.; Tozzi, F.; Treasure, J.; Tsitsika, A.; Tyszkiewicz-Nwafor, M.; Tziouvas, K.; Elburg, A.A. van; Furth, E.F. van; Walton, E.; Widen, E.; Zerwas, S.; Zipfel, S.; Bergen, A.W.; Boden, J.M.; Brandt, H.; Crawford, S.; Halmi, K.A.; Horwood, L.J.; Johnson, C.; Kaplan, A.S.; Kaye, W.H.; Mitchell, J.E.; Olsen, C.M.; Pearson, J.F.; Pedersen, N.L.; Strober, M.; Werge, T.; Whiteman, D.C.; Woodside, D.B.; Gordon, S.; Maguire, S.; Larsen, J.T.; Parker, R.; Petersen, L.; Jordan, J.; Kennedy, M.; Wade, T.D.; Birgegård, A.; Lichtenstein, P.; Landén, M.; Martin, N.G.; Mortensen, P.B.; Breen, G. & Bulik, C.M. (2022), Common genetic variation and age of onset of anorexia nervosa, Biological Society Global Open Science 2(4): 368-378.
- Timmermans, R.G.M.; Blom, A.B.; Bloks, N.G.C.; Nelissen, R.G.H.H.; Linden, E.H.M.J. van der; Kraan, P.M. van der; Meulenbelt, I.; Ramos, Y.F.M. & Bosch, M.H.J. van den (2022), CCN4/WISP1 promotes migration of human primary osteoarthritic chondrocytes, Cartilage 14(1).
- Hoolwerff, M. van; Tuerlings, M.; Wijnen, I.J.; Suchiman, E.H.; Cats, D.; Nelissen, R.G.; Linden, E.M. van der; Mei, H.; Ramos, Y.F.; Almeida, R.C. de & Meulenbelt, I. (2022), IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION IMBALANCED OSTEOARTHRITIS ASSOCIATED FIBRONECTIN SPLICE VARIANTS, Osteoarthritis and Cartilage 30: S17-S18.
- Tuerlings, M.; Janssen, G.; Boone, I.; Hoolwerff, M. van; Ruiz, A.R.; Houtman, E.; Suchiman, E.; Wal, R. van der; Nelissen, R.; Almeida, R.C. de; Veelen, P. van; Ramos, Y. & Meulenbelt, I. (2022), FUNCTIONAL GENOMICS HIGHLIGHTS ROLE FOR OSTEOARTHRITIS SUSCEPTIBILITY GENE WWP2 IN CARTILAGE MATRIX DEPOSITION, Osteoarthritis and Cartilage 30: S180-S180.
- Houtman, E.; Tuerlings, M.; Suchiman, H.E.D.; Lakenberg, N.; Cornelis, F.M.F.; Mei, H.L.; Broekhuis, D.; Nelissen, R.G.H.H.; Almeida, R.C. de; Ramos, Y.F.M.; Lories, R.J.; Cruz, L.J. & Meulenbelt, I. (2022), Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes, Rheumatology 62(1).
- Tuerlings, M.; Boone, I.; Amirabadi, H.E.; Vis, M.; Suchiman, E.; Linden, E. van der; Hofmann, S.; Nelissen, R.; Toonder, J.; Ramos, Y. & Meulenbelt, I. (2022), Capturing essential physiological aspects of interacting cartilage and bone tissue with osteoarthritis pathophysiology, Advanced Materials Technologies 7(8).
- Kreitmaier, P.; Suderman, M.; Southam, L.; Almeida, R.C. de; Hatzikotoulas, K.; Meulenbelt, I.; Steinberg, J.; Relton, C.; Wilkinson, J.M. & Zeggini, E. (2022), AN EPIGENOME-WIDE VIEW OF OSTEOARTHRITIS IN PRIMARY TISSUES, Osteoarthritis and Cartilage 30: S48-S48.
- Almeida, R.C. de; Tuerlings, M.; Ramos, Y.; Hollander, W. den; Suchiman, E.; Lakenberg, N.; Nelissen, R.G.H.H.; Mei, H.L. & Meulenbelt, I. (2022), Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis, Rheumatology.
- Kreitmaier, P.; Suderman, M.; Southam, L.; Almeida, R.C. de; Hatzikotoulas, K.; Meulenbelt, I.; Steinberg, J.; Relton, C.; Wilkinson, J.M. & Zeggini, E. (2022), An epigenome-wide view of osteoarthritis in primary tissues, European Journal of Human Genetics 30(SUPPL 1): 66-67.
- Korthagen, N.; Houtman, E.; Boone, I.; Almeida, R.C. de; Sivasubramaniyan, K.; Nelissen, R.; Ramos, Y.; Tessari, M. & Meulenbelt, I. (2022), RNA SEQUENCING REVEALS MARKERS AND PATHWAYS OF T3-INDUCED CARTILAGE HYPERTROPHY, Tissue Engineering Part A 28: S601-S601.
- Korthagen, N.M.; Houtman, E.; Boone, I.; Almeida, R.C. de; Sivasubramaniyan, K.; Nelissen, R.G.; Ramos, Y.F.; Tessari, M.A. & Meulenbelt, I. (2022), RNA SEQUENCING REVEALS NOVEL MARKERS AND PATHWAYS OF T3-INDUCED CARTILAGE HYPERTROPHY, Osteoarthritis and Cartilage 30: S345-S346.
- Ruiz, A.R.; Hoolwerff, M. van; Sprangers, S.; Suchiman, E.; Schoenmaker, T.; Dibbets-Schneider, P.; Bloem, J.L.; Nelissen, R.G.H.H.; Freund, C.; Mummery, C.; Everts, V.; Vries, T.J. de; Ramos, Y.F.M. & Meulenbelt, I. (2022), Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization, Rheumatology 62(1).
- Bloks, N.G.; Harissa, Z.; Dicks, A.; Almeida, R.C. de; Hajmousa, G.; Adkar, S.S.; Guilak, F.; Ramos, Y.F. & Meulenbelt, I. (2022), OSTEOARTHRITIS-RISK MUTATION IN PERICELLULAR MATRIX COL6A3 FIBRILS ALTERS BIOLOGIC RESPONSE OF CHONDROCYTES TO HYPER-PHYSIOLOGIC MECHANICAL LOADING CONDITIONS, Osteoarthritis and Cartilage 30: S12-S13.
- Hoolwerff, M. van; Tuerlings, M.; Wijnen, I.J.L.; Suchiman, H.E.D.; Cats, D.; Mei, H.L.; Nelissen, R.G.H.H.; Linden-van der Zwaag, H.M.J. van der; Ramos, Y.F.M.; Almeida, R.C. de & Meulenbelt, I. (2022), Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants, Rheumatology 62(2).
- Monteagudo, S.; Cornelis, F.M.F.; Wang, X.; Roover, A. de; Peeters, T.; Quintiens, J.; Sermon, A.; Almeida, R.C. de; Meulenbelt, I. & Lories, R.J. (2022), ANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease, Osteoarthritis and Cartilage 30(5): 724-734.
- Katsoula, G.; Steinberg, J.; Tuerlings, M.; Almeida, R.C. de; Southam, L.; Swift, D.; Meulenbelt, I.; Wilkinson, J.M. & Zeggini, E. (2022), A MOLECULAR MAP OF LONG NON-CODING RNA EXPRESSION, ISOFORM SWITCHING AND ALTERNATIVE SPLICING IN OSTEOARTHRITIS, Osteoarthritis and Cartilage 30: S352-S352.
- Katsoula, G.; Steinberg, J.; Tuerlings, M.; Almeida, R.C. de; Southam, L.; Swift, D.; Meulenbelt, I.; Wilkinson, J.M. & Zeggini, E. (2022), A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis, Human Molecular Genetics 31(12).
- Tuerlings, M.; Hoolwerff, M. van; Houtman, E.; Suchiman, E.H.E.D.; Lakenberg, N.; Mei, H.L.; Linden, E.H.M.J. van der; Nelissen, R.R.G.H.H.; Ramos, Y.Y.F.M.; Almeida, R.C. de & Meulenbelt, I. (2021), RNA sequencing reveals interacting key determinants of osteoarthritis acting in subchondral bone and articular cartilage, Arthritis and Rheumatology 73(5).
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- Zeggini, E.; Panoutsopoulou, K.; Southam, L.; Rayner, N.W.; Day-Williams, A.G.; Lopes, M.C.; Boraska, V.; Esko, T.; Evangelou, E.; Hofman, A.; Houwing-Duistermaat, J.J.; Ingvarsson, T.; Jonsdottir, I.; Jonsson, H.; Kerkhof, H.J.M.; Kloppenburg, M.; Bos, S.D.; Mangino, M.; Metrustry, S.; Slagboom, P.E.; Thorleifsson, G.; Raine, E.V.A.; Ratnayake, M.; Ricketts, M.; Beazley, C.; Blackburn, H.; Bumpstead, S.; Elliott, K.S.; Hunt, S.E.; Potter, S.C.; Shin, S.Y.; Yadav, V.K.; Zhai, G.J.; Sherburn, K.; Dixon, K.; Arden, E.; Aslam, N.; Battley, P.K.; Carluke, I.; Doherty, S.; Gordon, A.; Joseph, J.; Keen, R.; Koller, N.C.; Mitchell, S.; O'Neill, F.; Paling, E.; Reed, M.R.; Rivadeneira, F.; Swift, D.; Walker, K.; Watkins, B.; Wheeler, M.; Birrell, F.; Ioannidis, J.P.A.; Meulenbelt, I.; Metspalu, A.; Rai, A.; Salter, D.; Stefansson, K.; Styrkarsdottir, U.; Uitterlinden, A.G.; Meurs, J.B.J. van; Chapman, K.; Deloukas, P.; Ollier, W.E.R.; Wallis, G.A.; Arden, N.; Carr, A.; Doherty, M.; McCaskie, A.; Wilkinson, J.M.; Ralston, S.H.; Valdes, A.M.; Spector, T.D.; Loughlin, J. & arcOGEN Consortium & arcOGEN Colla (2012), Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study, Lancet 380(9844): 815-823.
- Bay-Jensen, A.C.; Slagboom, E.; Chen-An, P.; Alexandersen, P.; Qvist, P.; Christiansen, C.; Meulenbelt, I. & Karsdal, M.A. (2012), Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis., Menopause.
- Claessen, K.M.J.A.; Kloppenburg, M.; Kroon, H.M.; Bijsterbosch, J.; Pereira, A.M.; Romijn, H.A.; Straaten, T. van der; Beekman, M.; Slagboom, P.E.; Biermasz, N.R. & Meulenbelt, I. (2012), A Functional Growth Hormone Receptor Polymorphism, Exon 3 Deleted Ghr, Is Associated with Radiographic Knee Osteoarthritis in Females with Familial Osteoarthritis At Multiple Sites: The Garp Study., Arthritis and Rheumatism 64(10): S472-S473.
- Bos, S.D.; Beekman, M.; Maier, A.B.; Karsdal, M.A.; Kwok, W.Y.; Bay-Jensen, A.C.; Kloppenburg, M.; Slagboom, P.E. & Meulenbelt, I. (2012), Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles., Annals of the Rheumatic Diseases.
- Brandys, M.K.; Landt, M.C.T.S.O.; Elburg, A.A. van; Ophoff, R.; Verduijn, W.; Meulenbelt, I.; Middeldorp, C.M.; Boomsma, D.I.; Furth, E.F. van; Slagboom, E.; Kas, M.J.H. & Adan, R.A.H. (2012), Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data, Psychiatric Genetics 22(3): 130-136.
- Bos, S.D.; Bovee, J.V.M.G.; Duijnisveld, B.J.; Raine, E.V.A.; Dalen, W.J.; Ramos, Y.F.M.; Breggen, R. van der; Nelissen, R.G.H.H.; Slagboom, P.E.; Loughlin, J. & Meulenbelt, I. (2012), Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues., Annals of the Rheumatic Diseases 71(7): 1254-8.
- Hogervorst, T.; Eilander, W.; Fikkers, J.T. & Meulenbelt, I. (2012), Hip Ontogenesis: How Evolution, Genes, and Load History Shape Hip Morphotype and Cartilotype, Clinical Orthopaedics and Related Research 470(12): 3284-3296.
- Meulenbelt, I. (2012), Osteoarthritis year 2011 in review: genetics, Osteoarthritis and Cartilage 20(3): 218-222.
- Kerkhof, H.J.M.; Evangelou, E.; Meulenbelt, I.; Meurs, J.B.J. van; Zeggini, E. & Valdes, A.M. (2012), Human genetic studies on osteoarthritis from clinicians' viewpoints Reply, Osteoarthritis and Cartilage 20(3): 250-251.
- Dastani, Z.; Hivert, M.F.; Timpson, N.; Perry, J.R.B.; Yuan, X.; Scott, R.A.; Henneman, P.; Heid, I.M.; Kizer, J.R.; Lyytikainen, L.P.; Fuchsberger, C.; Tanaka, T.; Morris, A.P.; Small, K.; Isaacs, A.; Beekman, M.; Coassin, S.; Lohman, K.; Qi, L.; Kanoni, S.; Pankow, J.S.; Uh, H.W.; Wu, Y.; Bidulescu, A.; Rasmussen-Torvik, L.J.; Greenwood, C.M.T.; Ladouceur, M.; Grimsby, J.; Manning, A.K.; Liu, C.T.; Kooner, J.; Mooser, V.E.; Vollenweider, P.; Kapur, K.A.; Chambers, J.; Wareham, N.J.; Langenberg, C.; Frants, R.; Willems-vanDijk, K.; Oostra, B.A.; Willems, S.M.; Lamina, C.; Winkler, T.W.; Psaty, B.M.; Tracy, R.P.; Brody, J.; Chen, I.; Viikari, J.; Kahonen, M.; Pramstaller, P.P.; Evans, D.M.; St Pourcain, B.; Sattar, N.; Wood, A.R.; Bandinelli, S.; Carlson, O.D.; Egan, J.M.; Bohringer, S.; Heemst, D. van; Kedenko, L.; Kristiansson, K.; Nuotio, M.L.; Loo, B.M.; Harris, T.; Garcia, M.; Kanaya, A.; Haun, M.; Klopp, N.; Wichmann, H.E.; Deloukas, P.; Katsareli, E.; Couper, D.J.; Duncan, B.B.; Kloppenburg, M.; Adair, L.S.; Borja, J.B.; Wilson, J.G.; Musani, S.; Guo, X.Q.; Johnson, T.; Semple, R.; Teslovich, T.M.; Allison, M.A.; Redline, S.; Buxbaum, S.G.; Mohlke, K.L.; Meulenbelt, I.; Ballantyne, C.M.; Dedoussis, G.V.; Hu, F.B.; Liu, Y.M.; Paulweber, B.; Spector, T.D.; Slagboom, P.E.; Ferrucci, L.; Jula, A.; Perola, M.; Raitakari, O.; Florez, J.C.; Salomaa, V.; Eriksson, J.G.; Frayling, T.M.; Hicks, A.A.; Lehtimaki, T.; Smith, G.D.; Siscovick, D.S.; Kronenberg, F.; Duijn, C. van; Loos, R.J.F.; Waterworth, D.M.; Meigs, J.B.; Dupuis, J.; Richards, J.B.; DIAGRAM Consortium; MAGIC Consortium; GLGC Investigators & MuTHER Consortium (2012), Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals, PLoS Genetics 8(3): -.
- Guler-Yuksel, M.; Bijsterbosch, J.; Allaart, C.F.; Meulenbelt, I.; Kroon, H.M.; Watt, I.; Lems, W.F. & Kloppenburg, M. (2011), Accelerated metacarpal bone mineral density loss is associated with radiographic progressive hand osteoarthritis., Annals of the Rheumatic Diseases 70(9): 1625-30.
- Guler-Yuksel, M.; Bijsterbosch, J.; Allaart, C.F.; Meulenbelt, I.; Kroon, H.M.; Watt, I.; Lems, W.F. & Kloppenburg, M. (2011), Accelerated metacarpal bone mineral density loss is associated with radiographic progressive hand osteoarthritis, Annals of the Rheumatic Diseases 70(9): 1625-1630.
- Landt, M.C.T.S.O. 't; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C.M.; Houwing-Duistermaat, J.J.; Trier, J. van; Onkenhout, E.J.; Vink, J.M.; Beijsterveldt, C.E.M. van; Brandys, M.K.; Sanders, N.; Zipfel, S.; Herzog, W.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; Zwaan, M. de; Herpertz, S.; Ehrlich, S.; Elburg, A.A. van; Adan, R.A.H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D.I.; Furth, E.F. van & Slagboom, P.E. (2011), Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting, Genes, Brain and Behavior 10(2): 236-243.
- Bijsterbosch, J.; Bemmel, J.M. van; Watt, I.; Meulenbelt, I.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2011), Systemic and local factors are involved in the evolution of erosions in hand osteoarthritis, Annals of the Rheumatic Diseases 70(2): 326-330.
- Meulenbelt, I.; Bos, S.D.; Chapman, K.; Breggen, R. van der; Houwing-Duistermaat, J.J.; Kremer, D.; Kloppenburg, M.; Carr, A.; Tsezou, A.; Gonzalez, A.; Loughlin, J. & Slagboom, E. (2011), Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility, Annals of the Rheumatic Diseases 70(1): 164-167.
- Wassenaar, M.J.E.; Biermasz, N.R.; Bijsterbosch, J.; Pereira, A.M.; Meulenbelt, I.; Smit, J.W.A.; Roelfsema, F.; Kroon, H.M.; Romijn, J.A. & Kloppenburg, M. (2011), Arthropathy in long-term cured acromeagaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis, Annals of the Rheumatic Diseases 70(2): 320-325.
- Finken, M.J.J.; Meulenbelt, I.; Dekker, F.W.; Frolich, M.; Walther, F.J.; Romijn, J.A.; Slagboom, P.E.; Wit, J.M. & Dutch POPS-19 Collaborative Study (2011), Abdominal Fat Accumulation in Adults Born Preterm Exposed Antenatally to Maternal Glucocorticoid Treatment Is Dependent on Glucocorticoid Receptor Gene Variation, Journal of Clinical Endocrinology and Metabolism 96(10): E1650-E1655.
- Bijsterbosch, J.; Watt, I.; Meulenbelt, I.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2011), Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years, Annals of the Rheumatic Diseases 70(1): 68-73.
- Kwok, W.Y.; Bijsterbosch, J.; Malm, S.H.; Biermasz, N.R.; Huetink, K.; Nelissen, R.G.; Meulenbelt, I.; Huizinga, T.W.J.; Klooster, R. van 't; Stoel, B.C. & Kloppenburg, M. (2011), Validity of joint space width measurements in hand osteoarthritis., Osteoarthritis and Cartilage 19(11): 1349-55.
- Meulenbelt, I.; Kraus, V.B.; Sandell, L.J. & Loughlin, J. (2011), Summary of the OA biomarkers workshop 2010 - genetics and genomics: new targets in OA., Osteoarthritis and Cartilage 19(9): 1091-4.
- Kwok, W.Y.; Bijsterbosch, J.; Malm, S.H.; Biermasz, N.R.; Huetink, K.; Nelissen, R.G.; Meulenbelt, I.; Huizinga, T.W.J.; Klooster, R. van 't; Stoel, B.C. & Kloppenburg, M. (2011), Validity of joint space width measurements in hand osteoarthritis, Osteoarthritis and Cartilage 19(11): 1349-1355.
- Euser, A.M.; Finken, M.J.J.; Kharagjitsingh, A.V.; Alizadeh, B.Z.; Roep, B.O.; Meulenbelt, I.; Dekker, F.W. & Wit, J.M. (2011), IGF1 Promoter Polymorphism and Cranial Growth in Individuals Born Very Preterm, Hormone Research in Paediatrics 76(1): 27-34.
- Bijsterbosch, J.; Bemmel, J.M. van; Watt, I.; Meulenbelt, I.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2011), Systemic and local factors are involved in the evolution of erosions in hand osteoarthritis., Annals of the Rheumatic Diseases 70(2): 326-30.
- Kerkhof, H.J.M.; Meulenbelt, I.; Akune, T.; Arden, N.K.; Aromaa, A.; Bierma-Zeinstra, S.M.A.; Carr, A.; Cooper, C.; Dai, J.; Doherty, M.; Doherty, S.A.; Felson, D.; Gonzalez, A.; Gordon, A.; Harilainen, A.; Hart, D.J.; Hauksson, V.B.; Heliovaara, M.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Jonsdottir, I.; Kawaguchi, H.; Kloppenburg, M.; Kujala, U.M.; Lane, N.E.; Leino-Arjas, P.; Lohmander, L.S.; Luyten, F.P.; Malizos, K.N.; Nakajima, M.; Nevitt, M.C.; Pols, H.A.P.; Rivadeneira, F.; Shi, D.; Slagboom, E.; Spector, T.D.; Stefansson, K.; Sudo, A.; Tamm, A.; Tamm, A.E.; Tsezou, A.; Uchida, A.; Uitterlinden, A.G.; Wilkinson, J.M.; Yoshimura, N.; Valdes, A.M. & Meurs, J.B.J. van (2011), Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium, Osteoarthritis and Cartilage 19(3): 254-264.
- Evangelou, E.; Valdes, A.M.; Kerkhof, H.J.M.; Styrkarsdottir, U.; Zhu, Y.Y.; Meulenbelt, I.; Lories, R.J.; Karassa, F.B.; Tylzanowski, P.; Bos, S.D.; Akune, T.; Arden, N.K.; Carr, A.; Chapman, K.; Cupples, L.A.; Dai, J.; Deloukas, P.; Doherty, M.; Doherty, S.; Engstrom, G.; Gonzalez, A.; Halldorsson, B.V.; Hammond, C.L.; Hart, D.J.; Helgadottir, H.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Kaprio, J.; Kawaguchi, H.; Kisand, K.; Kloppenburg, M.; Kujala, U.M.; Lohmander, L.S.; Loughlin, J.; Luyten, F.P.; Mabuchi, A.; McCaskie, A.; Nakajima, M.; Nilsson, P.M.; Nishida, N.; Ollier, W.E.R.; Panoutsopoulou, K.; Putte, T. van de; Ralston, S.H.; Rivadeneira, F.; Saarela, J.; Schulte-Merker, S.; Shi, D.Q.; Slagboom, P.E.; Sudo, A.; Tamm, A.; Tamm, A.; Thorleifsson, G.; Thorsteinsdottir, U.; Tsezou, A.; Wallis, G.A.; Wilkinson, J.M.; Yoshimura, N.; Zeggini, E.; Zhai, G.J.; Zhang, F.; Jonsdottir, I.; Uitterlinden, A.G.; Felson, D.T.; Meurs, J.B. van; Stefansson, K.; Ioannidis, J.P.A.; Spector, T.D.; ArcOGEN Consortium & Translation Res Europe Appl (2011), Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22, Annals of the Rheumatic Diseases 70(2): 349-355.
- Kerkhof, H.J.M.; Doherty, M.; Arden, N.K.; Abramson, S.B.; Attur, M.; Bos, S.D.; Cooper, C.; Dennison, E.M.; Doherty, S.A.; Evangelou, E.; Hart, D.J.; Hofman, A.; Javaid, K.; Kerna, I.; Kisand, K.; Kloppenburg, M.; Krasnokutsky, S.; Maciewicz, R.A.; Meulenbelt, I.; Muir, K.R.; Rivadeneira, F.; Samuels, J.; Sezgin, M.; Slagboom, E.; Smith, A.J.P.; Spector, T.D.; Tamm, A.; Tamm, A.; Uitterlinden, A.G.; Wheeler, M.; Zhai, G.; Zhang, W.; Meurs, J.B.J. van & Valdes, A.M. (2011), Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis, Osteoarthritis and Cartilage 19(3): 265-271.
- Panoutsopoulou, K.; Southam, L.; Elliott, K.S.; Wrayner, N.; Zhai, G.; Beazley, C.; Thorleifsson, G.; Arden, N.K.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Ollier, W.E.R.; Ralston, S.H.; Spector, T.D.; Valdes, A.M.; Wallis, G.A.; Wilkinson, J.M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F.J.; Bumpstead, S.; Cupples, L.A.; Day-Williams, A.G.; Dixon, K.; Doherty, S.A.; Esko, T.; Evangelou, E.; Felson, D.; Gomez-Reino, J.J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Halldorsson, B.V.; Hauksson, V.B.; Hofman, A.; Hunt, S.E.; Ioannidis, J.P.A.; Ingvarsson, T.; Jonsdottir, I.; Jonsson, H.; Keen, R.; Kerkhof, H.J.M.; Kloppenburg, M.G.; Koller, N.; Lakenberg, N.; Lane, N.E.; Lee, A.T.; Metspalu, A.; Meulenbelt, I.; Nevitt, M.C.; O'Neill, F.; Parimi, N.; Potter, S.C.; Rego-Perez, I.; Riancho, J.A.; Sherburn, K.; Slagboom, P.E.; Stefansson, K.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Thorsteinsdottir, U.; Tsezou, A.; Uitterlinden, A.G.; Meurs, J.B.J. van; Watkins, B.; Wheeler, M.; Mitchell, S.; Zhu, Y.; Zmuda, J.M.; Zeggini, E.; Loughlin, J. & arcOGEN Consortium (2011), Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study, Annals of the Rheumatic Diseases 70(5): 864-867.
- Wassenaar, M.J.E.; Biermasz, N.R.; Bijsterbosch, J.; Pereira, A.M.; Meulenbelt, I.; Smit, J.W.A.; Roelfsema, F.; Kroon, H.M.; Romijn, J.A. & Kloppenburg, M. (2011), Arthropathy in long-term cured acromeagaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis., Annals of the Rheumatic Diseases 70(2): 320-5.
- Waarsing, J.H.; Kloppenburg, M.; Slagboom, P.E.; Kroon, H.M.; Houwing-Duistermaat, J.J.; Weinans, H. & Meulenbelt, I. (2011), Osteoarthritis Susceptibility Genes Influence the Association Between Hip Morphology and Osteoarthritis, Arthritis and Rheumatism 63(5): 1349-1354.
- Landt, M.C.T.S.O.; Dolan, C.V.; Rebollo-Mesa, I.; Bartels, M.; Furth, E.F. van; Beijsterveldt, C.E.M. van; Meulenbelt, I.; Slagboom, P.E. & Boomsma, D.I. (2010), Sex differences in sum scores may be hard to interpret: The importance of measurement invariance. (vol 16, pg 415, 2010), Assessment 17(2): 278-278.
- Bijsterbosch, J.; Watt, I.; Meulenbelt, I.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2010), Clinical burden of erosive hand osteoarthritis and its relationship to nodes, Annals of the Rheumatic Diseases 69(10): 1784-1788.
- Bijsterbosch, J.; Visser, W.; Kroon, H.M.; Stamm, T.; Meulenbelt, I.; Huizinga, T.W.J. & Kloppenburg, M. (2010), Thumb base involvement in symptomatic hand osteoarthritis is associated with more pain and functional disability, Annals of the Rheumatic Diseases 69(3): 585-587.
- Meulenbelt, I.; Bos, S.D.; Kloppenburg, M.; Lakenberg, N.; Houwing-Duistermaat, J.J.; Watt, I.; Craen, A.J. de; Duijn, C.M. van & Slagboom, P.E. (2010), Interleukin-1 Gene Cluster Variants With Innate Cytokine Production Profiles and Osteoarthritis in Subjects From the Genetics, Osteoarthritis and Progression Study, Arthritis and Rheumatism 62(4): 1119-1126.
- Bijsterbosch, J.; Bemmel, J.M. van; Watt, I.; Meulenbelt, I.; Rosendaal, F.R.; Huizinga, T.W. & Kloppenburg, M. (2010), CARTILAGE LOSS AND PAIN ARE INDEPENDENT RISK FACTORS IN THE EVOLUTION OF EROSIVE HAND OSTEOARTHRITIS, Osteoarthritis and Cartilage 18: S126S126.
- Tufan, A.; Meulenbelt, I.; Bijsterbosch, J.; Kroon, H.M.; Bierma-Zeinstra, S.M.A.; Nelissen, R.G. & Kloppenburg, M. (2010), Familial influence on tibiofemoral alignment., Annals of the Rheumatic Diseases.
- Bijsterbosch, J.; Visser, W.; Kroon, H.M.; Stamm, T.; Meulenbelt, I.; Huizinga, T.W.J. & Kloppenburg, M. (2010), Thumb base involvement in symptomatic hand osteoarthritis is associated with more pain and functional disability., Annals of the Rheumatic Diseases.
- Panoutsopoulou, K.; Southam, L.; Rayner, W.; Zhai, G.; Beazley, C.; Arden, N.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Olher, W.; Ralston, S.; Spector, T.; Valdes, A.; Wallis, G.; Wilkinson, M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F.; Bumpstead, S.; Cupples, A.; Day-Williams, A.; Dixon, K.; Dohertys, S.; Elliott, K.; Evangelou, E.; Felson, D.; Gomez-Reino, J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Hofman, A.; Hunt, S.; Ioannidis, J.; Jonsdottir, I.; Keen, R.; Kerkhof, H.; Kloppenburg, M.; Koller, N.; Lakenberg, N.; Lane, N.; Lee, A.; Meulenbelt, I.; Nevitt, M.; O'Neill, F.; Parimi, N.; Potter, S.; Rego-Perez, I.; Riancho, J.; Sherburn, K.; Slagboom, E.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Tsezou, A.; Uitterlinden, A.; Meurs, J. van; Watkins, B.; Wheeler, M.; Mitchelle, S.; Zhu, Y.; Zmuda, J.; Zeggini, E.; Loughlin, J. & ArcOGEN Consortium (2010), THE arcOGEN CONSORTIUM: STAGE 1 OF A GENOME-WIDE ASSOCIATION SCAN FOR OSTEOARTHRITIS, Osteoarthritis and Cartilage 18: S166S167.
- Kerkhof, H.J.; Meulenbelt, I.; Arden, N.; Cooper, C.; Doherty, M.; Felson, D.; Gonzalez, A.; Ikegawa, S.; Jiang, Q.; Jonsdottir, I.; Kujala, U.; Lane, N.; Leino-Arjas, P.; Lohmander, S.; Luyten, F.; Nevitt, M.; Slagboom, E.; Spector, T.; Stefansson, K.; Tamm, A.; Tsezou, A.; Wilkinson, J.; Yoshimura, N.; Valdes, A. & Meurs, J. van (2010), RECOMMENDATIONS FOR STANDARDIZATION AND PHENOTYPE DEFINITIONS IN GENETIC STUDIES OF OSTEOARTHRITIS: THE TREAT-OA CONSORTIUM, Osteoarthritis and Cartilage 18: S160S160.
- Bijsterbosch, J.; Visser, W. & Kroon, H.M. (2010), Thumb base involvement in symptomatic hand osteoarthritis is associated with more pain and functional disability., Annals of the Rheumatic Diseases.
- Kerkhof, H.J.; Doherty, M.; Abramson, S.B.; Arden, N.K.; Attur, M.; Bos, S.; Cooper, C.; Doherty, S.A.; Evangelou, E.; Kerna, I.; Kisand, K.; Kloppenburg, M.; Maciewicz, R.A.; Meulenbelt, I.; Sezgin, M.; Slagboom, E.; Smith, A.; Spector, T.D.; Tamm, A.; Tamm, A.; Uitterlinden, A.G.; Wheeler, M.; Zhang, W.; Meurs, J.B. van & Valdes, A.M. (2010), LARGE SCALE META-ANALYSIS OF INTERLEUKIN-1 BETA AND INTERLEUKIN-1 RECEPTOR ANTAGONIST POLYMORPHISMS ON RISK OF RADIOGRAPHIC HIP AND KNEE OSTEOARTHRITIS AND SEVERITY OF KNEE OSTEOARTHRITIS, Osteoarthritis and Cartilage 18: S166S166.
- Kerkhof, H.J.M.; Meulenbelt, I.; Carr, A.; Gonzalez, A.; Hart, D.; Hofman, A.; Kloppenburg, M.; Lane, N.E.; Loughlin, J.; Nevitt, M.C.; Pols, H.A.P.; Rivadeneira, F.; Slagboom, E.P.; Spector, T.D.; Stolk, L.; Tsezou, A.; Uitterlinden, A.G.; Valdes, A.M. & Meurs, J.B.J. van (2010), Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis, BMC Medical Genetics 11.
- Biermasz, N.R.; Wassenaar, M.J.E.; Bijsterbosch, J.; Pereira, A.M.; Meulenbelt, I.; Roelfsema, F.; Kroon, H.; Romijn, J.A. & Kloppenburg, M. (2010), Arthropathy in Long-Term Cured Acromegaly; a Comparison with Primary Osteoarthritis, Endocrine Reviews 31(3): S854S854.
- Bos, S.D.; Lakenberg, N.; Breggen, R. van der; Houwing-Duistermaat, J.J.; Kloppenburg, M.; Craen, A.J.M. de; Beekman, M.; Meulenbelt, I. & Slagboom, P.E. (2010), A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels, European Journal of Human Genetics 18(8): 953-959.
- Callegaro, A.; Meulenbelt, I.; Kloppenburg, M.; Slagboom, P.E. & Houwing-Duistermaat, J.J. (2010), Allele-Sharing Statistics Using Information on Family History, Annals of Human Genetics 74: 547-554.
- Moxley, G.; Meulenbelt, I.; Chapman, K.; Diujn, C.M. van; Slagboom, P.E.; Neale, M.C.; Smith, A.J.P.; Carr, A.J. & Loughlin, J. (2010), Interleukin-1 region meta-analysis with osteoarthritis phenotypes, Osteoarthritis and Cartilage 18(2): 200-207.
- Kerkhof, H.J.M.; Lories, R.J.; Meulenbelt, I.; Jonsdottir, I.; Valdes, A.M.; Arp, P.; Ingvarsson, T.; Jhamai, M.; Jonsson, H.; Stolk, L.; Thorleifsson, G.; Zhai, G.J.; Zhang, F.; Zhu, Y.Y.; Breggen, R. van der; Carr, A.; Doherty, M.; Doherty, S.; Felson, D.T.; Gonzalez, A.; Halldorsson, B.V.; Hart, D.J.; Hauksson, V.B.; Hofman, A.; Ioannidis, J.P.A.; Kloppenburg, M.; Lane, N.E.; Loughlin, J.; Luyten, F.P.; Nevitt, M.C.; Parimi, N.; Pols, H.A.P.; Rivadeneira, F.; Slagboom, E.P.; Styrkarsdottir, U.; Tsezou, A.; Putte, T. van de; Zmuda, J.; Spector, T.D.; Stefansson, K.; Uitterlinden, A.G. & Meurs, J.B.J. van (2010), A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22, Arthritis and Rheumatism 62(2): 499-510.
- Landt, M.C.T.S.O. 't; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C.M.; Houwing-Duistermaat, J.J.; Trier, J. van; Onkenhout, E.J.; Vink, J.M.; Beijsterveldt, C.E.M. van; Brandys, M.K.; Sanders, N.; Zipfel, S.; Herzog, W.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; Zwaan, M. de; Herpertz, S.; Ehrlich, S.; Elburg, A.A. van; Adan, R.A.H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D.I.; Furth, E.F. van & Slagboom, P.E. (2010), Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting., Genes, Brain and Behavior.
- Tufan, A.; Meulenbelt, I.; Bijsterbosch, J.; Kroon, H.M.; Bierma-Zeinstra, S.M.A.; Nelissen, R.G. & Kloppenburg, M. (2010), Familial influence on tibiofemoral alignment, Annals of the Rheumatic Diseases 69(3): 542-545.
- Bos, S.D.; Lakenberg, N.; Breggen, R. van der; Houwing-Duistermaat, J.J.; Kloppenburg, M.; Craen, A.J.M. de; Beekman, M.; Meulenbelt, I. & Slagboom, P.E. (2010), A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels, European Journal of Human Genetics 18(8): 953-959.
- Houwing-Duistermaat JJ, Callegaro A & Meulenbelt I (2009), Weighting of the Test Statistic by Family History Improves the Power to Detect Linkage., Genetic Epidemiology 33(8): 799-799.
- Bos SD, Kloppenburg M, Suchiman E, van Beelen E, Slagboom PE & Meulenbelt I (2009), The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA., Osteoarthritis and Cartilage 17(5): 621-6.
- Kerkhof HJM, Jonsdottir I, Meulenbelt I, Stolk L, Valdes AM, Zhai G, Zhu Y, Doherty M, Doherty S, Tsezou A, Gonzalez A, Carr A, Felson DT, Styrkarsdottir U, Slagboom EP, Loughlin J, Rivadeneira F, Hofman A, Pols HAP, Spector TD, Uitterlinden AG & van Meurs JBJ (2009), A genome-wide association study identifies a common variant near the GRP22 gene as a new locus involved in prevalence and progression of osteoarthritis, BONE 44(2): S224S224.
- Rodriguez-Lopez J, Pombo-Suarez M, Loughlin J, Tsezou A, Blanco FJ, Meulenbelt I, Slagboom PE, Valdes AM, Spector TD & Gomez-Reino JJ (2009), Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes, Osteoarthritis and Cartilage 17(3): 321-327.
- Finken MJJ, Meulenbelt I, Dekker FW, Frolich M, Romijn J, Slagboom E & Wit JM (2009), Adverse body composition in adult life after perinatal glucocorticoid therapy in prematurely born individuals carrying the 363S variant of the N363S polymorphism in the glucocorticoid receptor gene, Hormone Research 72: 426-426.
- Slof-Op 't Landt MCT, van Furth EF, Rebollo-Mesa I, Bartels M, van Beijsterveldt CEM, Slagboom PE, Boomsma DI, Meulenbelt I & Dolan CV (2009), Sex Differences in Sum Scores May Be Hard to Interpret The Importance of Measurement Invariance, Assessment 16(4): 415-423.
- Bijsterbosch J, Visser W, Kroon H, Stamm T, Meulenbelt I, Huizinga T & Kloppenburg M (2009), PAIN AND FUNCTIONAL DISABILITY IN SYMPTOMATIC HAND OSTEOARTHRITIS DEPEND ON TYPE OF JOINT INVOLVEMENT, Osteoporosis International 20: 80-80.
- Zhai G, van Meurs JBJ, Livshits G, Meulenbelt I, Valdes AM, Soranzo N, Hart D, Zhang F, Kato BS, Richards JB, Williams FM, Inouye M, Kloppenburg M, Deloukas P, Slagboom E, Uitterlinden A & Spector TD (2009), A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium, Journal of Medical Genetics 46(9): 614-616.
- Meulenbelt I, Chapman K, Dieguez-Gonzalez R, Shi DQ, Tsezou A, Dai J, Malizos KN, Kloppenburg M, Carr A & Nakajima M (2009), Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations, Human Molecular Genetics 18(8): 1518-1523.
- Tufan A, Meulenbelt I, Bijsterbosch J, Kroon HM, Bierma-Zeinstra SMA, Nelissen RG & Kloppenburg M (2009), Familial influence on tibiofemoral alignment., Annals of the Rheumatic Diseases.
- Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gomez-Reino JJ & Gonzalez A (2009), Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand, Arthritis and Rheumatism 60(6): 1710-1721.
- Dieguez-Gonzalez R, Calaza M, Shi D, Meulenbelt I, Loughlin J, Tsezou A, Dai J, Malizos KN, Slagboom EP & Kloppenburg M (2009), Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections, Annals of the Rheumatic Diseases 68(6): 1017-1021.
- Bos SD, Kloppenburg M, Suchiman E, van Beelen E, Slagboom PE & Meulenbelt I (2009), The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA, Osteoarthritis and Cartilage 17(5): 621-626.
- Meulenbelt I, Chapman K, Dieguez-Gonzalez R, Shi D, Tsezou A, Dai J, Malizos KN, Kloppenburg M, Carr A, Nakajima M, van der Breggen R, Lakenberg N, Gomez-Reino JJ, Jiang Q, Ikegawa S, Gonzalez A, Loughlin J & Slagboom EP (2009), Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations., Human Molecular Genetics 18(8): 1518-23.
- Bijsterbosch J, Scharloo M, Visser AW, Watt I, Meulenbelt I, Huizinga TW, Kaptein AA & Kloppenburg M (2009), Illness perceptions in patients with osteoarthritis: change over time and association with disability., Arthritis and Rheumatism 61(8): 1054-61.
- Slagboom E & Meulenbelt I (2008), Genetics of osteoarthritis: early developmental clues to an old disease, Nature Clinical Practice Rheumatology 4(11).
- Bos SD, Slagboom PE & Meulenbelt I (2008), New insights into osteoarthritis: early developmental features of an ageing-related disease, Current Opinion in Rheumatology 20(5).
- Botha-Scheepers S, Watt I, Slagboom E, de Craen AJM, Meulenbelt I, Rosendaal FR, Breedveld FC, Huizinga TWJ & Kloppenburg M (2008), Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis, Annals of the Rheumatic Diseases 67(8).
- Chapman K, Takahashi A, Meulenbelt I, Watson C, Rodriguez-Lopez J, Egli R, Tsezou A, Malizos KN, Kloppenburg M, Shi DQ, Southam L, van der Breggen R, Donn R, Qin JH, Doherty M, Slagboom PE, Wallis G, Kamatani N, Jiang Q, Gonzalez A, Loughlin J & Ikegawa S (2008), A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5 ' UTR of GDF5 with osteoarthritis susceptibility, Human Molecular Genetics 17(10).
- Meulenbelt I, Min JL, Bos S, Riyazi N, Houwing-Duistermaat JJ, van der Wijk HJ, Kroon HM, Nakajima M, Ikegawa S, Uitterlinden AG, van Meurs JBJ, van der Deure WM, Visser TJ, Seymour AB, Lakenberg N, van der Breggen R, Kremer D, van Duijn CM, Kloppenburg M, Loughlin J & Slagboom PE (2008), Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis, Human Molecular Genetics 17(12).
- Colas F, Meulenbelt I, Houwing-Duistermaat JJ, Slagboom PE & Kok JN (2008), A comparison of two methods for finding groups using heat maps and model based clustering, APPLICATIONS AND INNOVATIONS IN INTELLIGENT SYSTEMS XV: 119-131.
- Colas F, Meulenbelt I, Houwing-Duistermaat JJ, Kloppenburg M, Watt I, van Rooden SA, Visser M, Marinus J, Cannon EO, Bender A, van Hilten JJ, Slagboom PE & Kok JN (2008), A Scenario Implementation in R for SubtypeDiscovery Examplified on Chemoinformatics Data, LEVERAGING APPLICATIONS OF FORMAL METHODS, VERIFICATION AND VALIDATION, PROCEEDINGS 17: 669-683.
- 't Landt MCTSO, Bartels M, van Furth EF, van Beijsterveldt CEM, Meulenbelt I, Slagboom PE & Boomsma DI (2008), Genetic influences on disordered eating behaviour are largely independent of body mass index.
- Colas F, Meulenbelt I, Houwing-Duistermaat JJ, Kloppenburg M, Watt I, van Rooden SM, Visser M, Marinus J, van Hilten JJ, Slagboom PE & Kok JN (2008), Reliability of Cluster Results for Different Types of Time Adjustments in Complex Disease Research, 2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8: 4601-4604.
- Bos SD, Suchiman HED, Kloppenburg M, Houwing-Duistermaat JJ, le Graverand MPH, Seymour AB, Kroon HM, Slagboom PE & Meulenbelt I (2008), Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study, Annals of the Rheumatic Diseases 67(6).
- Botha-Scheepers S, Watt I, Slagboom E, Craen AJM, Meulenbelt I, Rosendaal F, Breedveld FC, Huizinga TWJ & Kloppenburg M (2007), Innate production of tumor necrosis factor-alpha and interleukin-10 is associated with radiological progression of knee osteoarthritis, Annals of the Rheumatic Diseases 66.
- Botha-Scheepers SA, Watt I, Slagboom E, Meulenbelt I, Rosendaal FR, Breedveld FC & Kloppenburg M (2007), Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: A prospective longitudinal cohort study, Arthritis and Rheumatism 57(4).
- Loughlin J, Meulenbelt I, Min J, Mustafa Z, Sinsheimer JS, Carr A & Slagboom PE (2007), Genetic association analysis of RHOB and TXNDC3 in osteoarthritis, American Journal of Human Genetics 80(2).
- Slagboom PE, Heijmans BT, Beekman M & Meulenbelt I (2007), Molecular epidemiology, candidate genes versus genome-wide scans, Genes and Nutrition 2(1).
- Putter H, Meulenbelt I & van Houwelingen JC (2007), Relative efficiency of haplotype frequency estimation in sibships and nuclear families compared to unrelated individuals, Human Heredity 64(1).
- Meulenbelt I, Kloppenburg M, Kroon HM, Houwing-Duistermaat JJ, Garnero P, Hellio-Le Graverand MP, DeGroot J & Slagboom PE (2007), Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study, Osteoarthritis and Cartilage 15(4).
- Finken MJJ, Meulenbelt I, Dekker FW, Frolich M, Romijn JA, Slagboom PE & Wit JM (2007), The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth, Journal of Clinical Endocrinology and Metabolism 92(12).
- Mayboroda OA, Neususs C, Pelzing M, Zurek G, Derks R, Meulenbelt I, Kloppenburg M, Slagboom EP & Deelder AM (2007), Amino acid profiling in urine by capillary zone electrophoresis - mass spectrometry, Journal of Chromatography A 1159(1-2).
- Min JL, Meulenbelt I, Kloppenburg M, van Duijn CM & Slagboom PE (2007), Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis, European Journal of Human Genetics 15(7).
- Margarita, C.T.; Landt, S.O.T.; Bartels, M.; Furth, E.F. van; Meulenbelt, I.; Slagboom, E. & Boomsma, D.I. (2007), Genetic influences on disordered eating behavior are largely independent of BMI, Behavior Genetics 37(6): 794-794.
- Min JL, Meulenbelt I, Riyazi N, Putter H, Seymour A, Lakenberg N, Van Duijn C, Kloppenburg M & Slagboom E (2006), Genetic linkage analysis of osteoarthritis at multiple joint sites in Dutch sibpairs, Annals of the Rheumatic Diseases 65: 75-75.
- Meulenbelt I, Kloppenburg M, Kroon HM, Houwing-Duistermaat JJ, Garnero P, Le Graverand MPH, DeGroot J & Slagboom PE (2006), Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study, Annals of the Rheumatic Diseases 65(3).
- Botha-Scheepers S, Watt I, Slagboom E, de Craen T, Meulenbelt I, Rosendaal FR, Breedveld FC, Huizinga TWJ & Kloppenburg M (2006), Innate production of tumor necrosis factor-alpha and interleukin-10 upon lipopolysaccharide stimulation are associated with radiological progression of knee osteoarthritis., Arthritis and Rheumatism 54(9).
- Meulenbelt I, Min JL, van Duijn CM, Kloppenburg M, Breedveld FC & Slagboom PE (2006), Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes, European Journal of Human Genetics 14(12).
- Meulenbelt I, Kloppenburg M, Houwing-Duistermaat JJ, Garnero P, Le Graverand MH, DeGroot J & Slagboom PE (2006), Biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial oa at multiple sites. The GARP study, Annals of the Rheumatic Diseases 65: 589-589.
- Min JL, Lakenberg N, Bakker-Verweij M, Suchiman E, Boomsma DI, Slagboom PE & Meulenbelt I (2006), High microsatellite and SNP genotyping success rates established in a large number of genomic DNA samples extracted from mouth swabs and genotypes, Twin Research and Human Genetics 9(4).
- Min J, Meulenbelt I & Slagboom E (2006), Replication in genetic association studies: comment on the editorial by Spector et al, Arthritis and Rheumatism 54(9).
- Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, van Duijn CM & Slagboom PE (2006), Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand, Annals of the Rheumatic Diseases 65(8).
- Slof-Op 't Landt MCT, van Furth EF, Meulenbelt I, Slagboom RE, Bartels M, Boomsma DI & Bulik CM (2005), Eating disorders: From twin studies to candidate genes and beyond, Twin Research and Human Genetics 8(5).
- Posthuma D, Meulenbelt I, de Craen AJM, de Geus EJC, Slagboom PE, Boomsma DI & Westendorp RGJ (2005), Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors, Twin Research and Human Genetics 8(2).
- Meulenbelt I, Kloppenburg M, Min JL, Kroon HM, Houwing-Duistermaat JJ, Le Graverand MH, De Groot J & Slagboom E (2005), UCTX-II levels are influenced by radiographic osteoarthritis (OA) in hip, knee, hand, and facet joints in sibling pairs with familial OA at multiple sites. The GARP study, Annals of the Rheumatic Diseases 64.
- Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, Pols HA, van Duijn CM & Slagboom PE (2005), Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites, Arthritis and Rheumatism 52(4).
- Riyazi N, Slagboom E, de Craen AJM, Meulenbelt I, Houwing-Duistermaat JJ, Kroon HM, van Schaardenburg D, Rosendaal FR, Breedveld FC, Huizinga TWJ & Kloppenburg M (2005), Association of the risk of osteoarthritis with high innate production of interleukin-1 beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation, Arthritis and Rheumatism 52(5).
- Riyazi N, Meulenbelt I, Kroon HM, Ronday KH, le Graverand MPH, Rosendaal FR, Breedveld FC, Slagboom PE & Kloppenburg M (2005), Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study, Annals of the Rheumatic Diseases 64(3).
- Riyazi N, Slagboom E, de Craen AJ, Meulenbelt I, Houwing-Duistermaat JJ, Kroon HM, van Schaardenburg D, Rosendaal FR, Breedveld FC, Huizinga TW & Kloppenburg M (2005), Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation., Arthritis and Rheumatism 52(5): 1443-50.
- Alizadeh BZ, Njajou OT, Bijkerk C, Meulenbelt I, De Wildt SC, Hofman A, Pols HAP, Slagboom PE & van Duijn CM (2005), Evidence for a role of the genomic region of the gene encoding for the alpha 1 chain of type IX collagen (COL9A1) in hip osteoarthritis - A population-based study, Arthritis and Rheumatism 52(5).
- Meulenbelt I, Slagboom PE & van Duijn CM (2005), Accuracy of haplotype association studies is enhanced by increasing number of polymorphic loci examined: comment on the article by Meulenbelt et al - Reply, Arthritis and Rheumatism 52(2).
- Min J, Meulenbelt I, Kloppenburg M, Van Duijn CM & Slagboom E (2004), Genome wide scan in early onset generalized OA; Mutation and association analysis of candidate genes within the region of linkage, Annals of the Rheumatic Diseases 63: 120-120.
- Meulenbelt I, Min J, Kloppenburg M, Van Duijn CM & Slagboom E (2004), Genome wide scan in early onset generalized OA; Mutation analysis of a candidate gene, Annals of the Rheumatic Diseases 63: 120-120.
- Meulenbelt I, Kloppenburg G, Min J, Pickering E, Le Graverand MPH, Groot J & Slagboom PE (2004), Cross sectional evaluation of biochemical markers of bone and cartilage metabolism in sibling pairs with familial OA at multiple sites. The GARP study, Osteoarthritis and Cartilage 12: S92-S93.
- Riyazi N, Hulzinga TWJ, De Craen AJM, Meulenbelt I, Kroon HM, Rosendaal FR, Breedveld FC, Slagboom E & Kloppenburg M (2004), Identification of three new genetically determined risk factors for osteoarthritis (OA): High levels of interleukin (IL)-1beta and IL-receptor antagonist (IL-1Ra) and low IL-10 production, Annals of the Rheumatic Diseases 63.
- Riyazi N, Huizinga TJ, de Craen AR, Meulenbelt I, Kroon HM, Rosendaal R, Breedveld FC, Slagboom E & Kloppenburg M (2004), Identification of three new genetically determined risk factors for osteoarthritis (OA): High levels of interleukin (IL)-1 beta and IL-receptor antagonist (IL-1Ra) and low IL-10 production, Annals of the Rheumatic Diseases 63.
- Meulenbelt I, Seymour AB, Nieuwland M, Huizinga TWJ, van Duijn CM & Slagboom PE (2004), Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip, Arthritis and Rheumatism 50(4).
- Botha-Scheepers SA, Riyazi N, Kroon HM, Slagboom E, Meulebelt I, Rosendaal FR, Breedveld FC & Kloppenburg M (2004), Pain and disability in the lower extremities in patients with osteoarthritis (OA) at multiple sites are associated with lumbar spine OA, the number of oa joints, range of motion and psychological factors, Annals of the Rheumatic Diseases 63.
- Zhai G, Rivadeneira F, Houwing-Duistermat JJ, Meulenbelt I, Bijkerk C, Hofman A, van Meurs JBJ, Uitterlinden AG, Pols HAP, Slagboom PE & van Duijn CM (2004), Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha 1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study, Annals of the Rheumatic Diseases 63(5).
- Riyazi N, Meulenbelt I, Kroon HM, le Graverand MPH, Woodworth T, Rosendaal FR, Breedveld FC, Slagboom PE & Kloppenburg M (2003), Evidence for familial aggregation of hip, hand and spine osteoarthritis (OA) in siblings with clinical and radiological OA. The GARP study., Arthritis and Rheumatism 48(9).
- Meulenbelt I, Seymour A, Nieuwland M, Bijkerk C, Gabel CA, Huizinga T, van Duijn CM & Slagboom PE (2002), Interleukin-1 polymorphism significantly associated with increased risk for hip osteoarthritis in females., American Journal of Human Genetics 71(4): 347-347.
- Slagboom PE & Meulenbelt I (2002), Organisation of the human genome and our tools for identifying disease genes, Biological Psychology 61(1-2).
- Meulenbelt I, Slagboom PE & van Duijn C (2000), Analysis of the association of the matrillin-1 gene (CRTM) with osteoarthritis: comment on the article by Meulenbelt et al - Reply.
- van Meurs JBJ, Arp PP, Fang Y, Slagboom PE, Meulenbelt I, van Leeuwen JPTM, Pols HAP & Uitterlinden AG (2000), Detection of sequence variability of the collagen type II alpha 1 3 ' variable number of tandem repeat, ELECTROPHORESIS 21(17).
- Slagboom PE, Heijmans BT, Beekman M, Westendorp RGJ & Meulenbelt I (2000), Genetics of human aging - The search for genes contributing to human longevity and diseases of the old.
- Meulenbelt I, Bijkerk C, De Wildt SCM, Miedema HS, Breedveld FC, Pols HAP, Hofman A, Van Duijn CM & Slagboom PE (1999), Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis.
- Meulenbelt I, Bijkerk C, Houwing-Duistermaat JJ, Breedveld FC, van Duijn CM & Slagboom PE (1999), Genetic studies on osteoarthritis., American Journal of Human Genetics 65(4): A435-A435.
- Bijkerk C, Houwing-Duistermaat JJ, Valkenburg HA, Meulenbelt I, Hofman A, Breedveld FC, Pols HAP, van Duijn CM & Slagboom PE (1999), Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine, Arthritis and Rheumatism 42(8): 1729-1735.
- Slagboom PE, Bijkerk C, Houwing-Duistermaat JJ, Valkenburg HA, Meulenbelt I, Hofman A, Breedveld FC, Pols HAP & van Duijn CM (1999), Heritability and candidate gene studies in Osteoarthritis, Zeitschrift f�r Gerontologie und Geriatrie 32(2): 127-127.
- Bijkerk, C.; Houwing-Duistermaat, J.J.; Meulenbelt, I.; Valkenburg, H.A.; Hofman, A.; Breedveld, F.C.; Pols, H.A.P.; Stijnen, T.; Dujin, C.M. van & Slagboom, P.E. (1998), The genetic influence on the occurrence of radiological osteoarthritis., Arthritis and Rheumatism 41(9): S145-S145.