Henricus Verspaget
Emeritus hoogleraar Biobanking
- Naam
- Prof.dr.ir. H.W. Verspaget
- h.w.verspaget@umail.leidenuniv.nl
- ORCID iD
- 0000-0001-5769-6887
Hein W. Verspaget is hoogleraar Biobanking van het Leids Universitair Medisch Centrum (LUMC). Daarnaast is hij biobankcoördinator van het LUMC en UMC/biobankcoördinator van het LUMC voor het Parelsnoer Instituut van de Nederlandse Federatie van Universitair Medische Centra (NFU). Tevens is hij staflid van de afdeling Maag-, Darm en Leverziekten van het LUMC. Daarnaast is hij bestuurslid van de Nederlandse Vereniging voor Gastroenterologie en lid van het uitvoerend comité van de Nederlandse Donor Feces Bank.
Biobank
Doelstelling van de leerstoel Biobanking en van de gecentraliseerde biobankorganisatie in het LUMC, onder leiding van Hein W. Verspaget, is het inrichten van biobanken voor ziektebeelden naar een uniforme en hoge kwaliteit van uitvoering op basis van (inter)nationale wet- en regelgeving. De biobanken hebben daarbij echter geen directe zorgfunctie voor de patiënten die daaraan deelnemen. Het belang van deelname door de patiënten aan de biobankverzameling wordt wel duidelijk gemaakt middels achtergrond informatie en informed consent, ten einde door biobank-gerelateerd onderzoek te kunnen komen tot verbeteringen in de kennis over ziektebeelden en in de zorg. Resultaten uit dat onderzoek worden daarbij openbaar gemaakt in wetenschappelijke publicaties en gebruikt in cyclische verbeterprocessen van de zorgverlening. De inter-divisionele biobankorganisatie van het LUMC voorziet daarbij de profileringsgebieden van het onderzoek van een duurzame, kwalitatief hoogstaande en toerekenbare biobank faciliteit die bijdraagt aan de valorisatie van biomedische onderzoeksinspanningen. Dit draagt tevens bij aan een grotere betrokkenheid en (publiek) bewustzijn van de patiënten, artsen en basale onderzoekers aan het grote belang van biobanking voor klinische innovatie.
Wetenschappelijke carrière
Als opgeleid celbioloog begon Hein W. Verspaget zijn onderzoekerscarrière op het gebied van aandoeningen in het maag-damkanaal in 1979. Hij deed onderzoek naar cellulaire en biochemische veranderingen bij chronische darmontstekingen op de afdeling Maag-, Darm- en Leverziekten van het LUMC. Hij promoveerde in 1987 in Leiden op zijn proefschrift getiteld: Cellular activity in Crohn’s disease, abnormalities in the immune response. Vervolgens deed hij jarenlang onderzoek en begeleiding van onderzoek op Maag-Darmtumoren en op het gebied van leverziekten en levertransplantatie op deze afdeling, waar hij nog steeds actief bij is betrokken. In december 2014 werd hij benoemd tot hoogleraar Biobanking van het Leids Universitair Medisch Centrum. De titel van zijn inaugurele rede was: Biobankieren voor translationeel onderzoek: valuta, regels en speelveld.
Emeritus hoogleraar Biobanking
- Faculteit Geneeskunde
- Divisie 2
- Maag-, Darm- en Leverziekten
- Broekhoven, A.G.C.; Ostyn, T.; Melkebeke, L. van; Verspaget, H.W.; Merwe, S. van der; Verbeek, J.; Coenraad, M.J.; Roskams, T.A. & Nevens, F. (2024), Histological characteristics in patients admitted to the hospital with alcoholic hepatitis complicated by acute-on-chronic liver failure, Scandinavian Journal of Gastroenterology 59(5): 577-583.
- Schaapman, J.; Shumbayawonda, E.; Castelo-Branco, M.; Alves, F.C.; Costa, T.; Fitzpatrick, E.; Tupper, K.; Dhawan, A.; Deheragoda, M.; Sticova, E.; French, M.; Beyer, C.; Rymell, S.; Tonev, D.; Verspaget, H.; Neubauer, S.; Banerjee, R.; Lamb, H. & Coenraad, M. (2024), MRI-serum-based score accurately identifies patients undergoing liver transplant without rejection avoiding the need for liver biopsy, Liver Transplantation.
- Lingen, E. van; Nooij, S.; Terveer, E.M.; Crossette, E.; Prince, A.L.; Bhattarai, S.K.; Watson, A.; Galazzo, G.; Menon, R.; Szabady, R.L.; Bucci, V.; Norman, J.M.; Woude, C.J. van der; Marel, S. van der; Verspaget, H.W.; Meulen-de Jong, A.E. van der & Keller, J.J. (2024), Faecal microbiota transplantation engraftment after budesonide or placebo in patients with active ulcerative colitis using pre-selected donors, Journal of Crohn's and Colitis 18(9): 1381-1393.
- Ouboter, L.F.; Barnhoorn, M.C.; Verspaget, H.W.; Plug, L.; Pool, E.S.; Szuhai, K.; Hawinkels, L.J.A.C.; Pel, M. van; Zwaginga, J.J.; Roelen, D.; Koning, F.; Pascutti, M.F. & Meulen-de Jong, A.E. van der (2023), Local administration of mesenchymal stromal cells is safe and modulates the immune compartment in ulcerative proctitis, JCI Insight 8(9).
- Broekhoven, A.; Ostyn, T.; Melkebeke, L. van; Verspaget, H.W.; Merwe, S. van der; Verbeek, J.; Coenraad, M.; Roskams, T. & Nevens, F. (2022), Ductular bilirubinostasis is a diagnostic biomarker for acute-on-chronic liver failure: results from a well-defined cohort of patients with alcoholic steatohepatitis, Journal of Hepatology 77: S144-S144.
- Broekhoven, A.; Postma, R.; Boer, H.C. de; Verspaget, H.W.; Hankemeier, T.; Coenraad, M.J.; Zonneveld, A.J. van & Duinen, V. van (2022), NOVEL MORPHOLOGICAL PROFILING ASSAY TO STUDY THE ROLE OF ENDOTHELIAL CELLS IN THE DISEASE TRAJECTORY OF LIVER CIRRHOSIS IN VITRO., Hepatology 76: S143-S144.
- Groenewegen, B.; Lingen, E. van; Ooijevaar, R.E.; Wessels, E.; Feltkamp, M.C.W.; Boeije-Koppenol, E.; Verspaget, H.W.; Kuijper, E.J.; Prehn, J. van; Keller, J.J.; Terveer, E.M. & Study Grp Netherlands Donor Feces (2022), How to prepare stool banks for an appropriate response to the ongoing COVID-19 pandemic, PLoS ONE 17(3).
- Barnhoorn, M.C.; Meulen-de Jong, A.E. van der; Schrama, E.C.L.M.; Plug, L.G.; Verspaget, H.W.; Fibbe, W.E.; Pel, M. van; Hawinkels, L.J.A.C. & Schepers, K. (2022), Cytokine mixtures mimicking the local milieu in patients with inflammatory bowel disease impact phenotype and function of mesenchymal stromal cells, Stem Cells Translational Medicine 11(9).
- Schaapman, J.; Ostyn, T.; Helm, D. van der; Haele, M. van; Reijden, J. van der; Nevens, F.; Verspaget, H.W.; Roskams, T. & Coenraad, M. (2021), Systemic and hepatic endothelial cell activation biomarkers expression are associated with inflammation and disease progression in patients with cirrhosis, Journal of Hepatology 75: S336-S337.
- Ooijevaar, R.E.; Nood, E. van; Goorhuis, A.; Terveer, E.M.; Prehn, J. van; Verspaget, H.W.; Beurden, Y.H. van; Dijkgraaf, M.G.W. & Keller, J.J. (2021), Ten-Year Follow-Up of Patients Treated with Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection from a Randomized Controlled Trial and Review of the Literature, Microorganisms 9(3).
- Ooijevaar, R.E.; Nood, E. van; Goorhuis, A.; Terveer, E.M.; Prehn, J. van; Verspaget, H.W.; Beurden, Y.H. van; Dijkgraaf, M.G.W. & Keller, J.J. (2021), Ten-Year Follow-Up of Patients Treated with Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection from a Randomized Controlled Trial and Review of the Literature, Microorganisms 9(3).
- Drs, L.O.; Barnhoorn, M.; Pel, M. van; Zwaginga, J.J.; Hawinkels, L.; Maljaars, J.; Koning, F.; Verspaget, H. & Meulen-de de Jong, A. van der (2021), Locally injected allogeneic bone marrow-derived mesenchymal stromal cells for the treatment of refractory proctitis: clinical results of a phase IIa trial, Journal of Crohn's and Colitis 15: S381-S381.
- Ouboter, L.; Barnhoorn, M.; Plug, L.; Pel, M. van; Zwaginga, J.J.; Roelen, D.; Pascutti, E.; Koning, F.; Hawinkels, L.; Verspaget, H. & Meulen-de Jong, A. van der (2021), Endoscopically injected allogeneic mesenchymal stromal cells alter the mucosal immune cell compartment in patients with ulcerative proctitis, Journal of Crohn's and Colitis 15: S098-S099.
- Karkampouna, S.; Helm, D. van der; Scarpa, M.; Hoek, B. van; Verspaget, H.W.; Goumans, M.J.; Coenraad, M.J.; Kruithof, B.P.T. & Julio, M.K.D. (2021), Oncofetal protein CRIPTO is involved in wound healing and fibrogenesis in the regenerating liver and is associated with the initial stages of cardiac fibrosis, Cells 10(12).
- Ooijevaar, R.E.; Nood, E. van; Goorhuis, A.; Terveer, E.M.; Prehn, J. van; Verspaget, H.W.; Beurden, Y.H. van; Dijkgraaf, M.G.W. & Keller, J.J. (2021), Ten-year follow-up of patients treated with fecal microbiota transplantation for recurrent Clostridioides difficile infection from a randomized controlled trial and review of the literature, Microorganisms 9(3).
- Bruckner, R.S.; Spalinger, M.R.; Barnhoorn, M.C.; Feakins, R.; Fuerst, A.; Jehle, E.C.; Rickenbacher, A.; Turina, M.; Niechcial, A.; Lang, S.; Hawinkels, L.J.A.C.; Meulen-de Jong, A.E. van der; Verspaget, H.W.; Rogler, G. & Scharl, M. (2021), Contribution of CD3(+)CD8(-) and CD3(+)CD8(+) T cells to TNF-alpha overexpression in crohn disease-associated perianal fistulas and induction of epithelial-mesenchymal transition in HT-29 cells, Inflammatory Bowel Diseases 27(4): 538-549.
- Keller, J.J.; Ooijevaar, R.E.; Hvas, C.L.; Terveer, E.M.; Lieberknecht, S.C.; Hogenauer, C.; Arkkila, P.; Sokol, H.; Gridnyev, O.; Megraud, F.; Kump, P.K.; Nakov, R.; Goldenberg, S.D.; Satokari, R.; Tkatch, S.; Sanguinetti, M.; Cammarota, G.; Dorofeev, A.; Gubska, O.; Laniro, G.; Mattila, E.; Arasaradnam, R.P.; Sarin, S.K.; Sood, A.; Putignani, L.; Alric, L.; Baunwall, S.M.D.; Kupcinskas, J.; Link, A.; Goorhuis, A.G.; Verspaget, H.W.; Ponsioen, C.; Hold, G.L.; Tilg, H.; Kassam, Z.; Kuijper, E.J.; Gasbarrini, A.; Mulder, C.J.J.; Williams, H.R.T. & Vehreschild, M.J.G.T. (2021), A standardised model for stool banking for faecal microbiota transplantation, United European Gastroenterology Journal 9(2).
- Broekhoven, A.G.C.; Fiocco, M.; Sprengers, D.; Takkenberg, R.B.; Meer, S. van; Erpecum, K.J. van; Ramsoekh, D.; Verspaget, H.W.; Burgmans, M.C.; Osanto, S.; Baranski, A.G.; Hoek, B. van & Coenraad, M.J. (2021), Real-life data on the impact of successful downstaging in patients with hepatocellular carcinoma, European Journal of Internal Medicine 97.
- Nooij, S.; Ducarmon, Q.R.; Laros, J.F.J.; Zwittink, R.D.; Norman, J.M.; Smits, W.K.; Verspaget, H.W.; Keller, J.J.; Terveer, E.M.; Kuijper, E.J. & Netherlands Donor Feces Bank (2021), Fecal microbiota transplantation influences procarcinogenic Escherichia coli in recipient recurrent Clostridioides difficile patients, Gastroenterology 161(4): 1218-+.
- Vendrik, K.E.W.; Terveer, E.M.; Kuijper, E.J.; Nooij, S.; Boeije-Koppenol, E.; Sanders, I.M.J.G.; Lingen, E. van; Verspaget, H.W.; Berssenbrugge, E.K.L.; Keller, J.J.; Prehn, J. van & Netherlands Donor Faeces Bank Stud (2021), Periodic screening of donor faeces with a quarantine period to prevent transmission of multidrug-resistant organisms during faecal microbiota transplantation: a retrospective cohort study, The Lancet Infectious Diseases 21(5): 711-721.
- Drs, L.O.; Barnhoorn, M.C.; Hawinkels, L.J.A.C.; Pel, M. van; Zwaginga, J.J.; Verspaget, H.W.; Koning, F.; Pascutti, M.F. & Meulen-de Jong, A.E. van der (2020), High-dimensional mass cytometry after local MSC treatment in patients with refractory proctitis shows an effect on the myeloid compartment: preliminary data, Journal of Crohn's and Colitis 14: S174-S175.
- Polytarchou, C.; Hatziapostolou, M.; Koutsioumpa, M.; Christodoulou, N.; Yau, T.O.; Birli, E.; Pomenya, O.; Montiel-Duarte, C.; Joshi, S.M.; Hommes, D.W.; Verspaget, H.W.; Yu, J. & Iliopoulos, D. (2020), A lncRNA-histone acetyltransferase complex induces colorectal oncogenesis through regulation of a metabolic kinase network, Cancer Research 80(16).
- Terveer, E.M.; Gool, T. van; Ooijevaar, R.E.; Sanders, I.M.J.G.; Boeije-Koppenol, E.; Keller, J.J.; Bart, A.; Kuijper, E.J. & Netherlands Donor Feces Bank NDFB (2020), Human transmission of blastocystis by fecal microbiota transplantation without development of gastrointestinal symptoms in recipients, Clinical Infectious Diseases 71(10): 2630-2636.
- Barnhoorn, M.C.; Wasser, M.N.J.M.; Roelofs, H.; Maljaars, P.W.J.; Molendijk, I.; Bonsing, B.A.; Oosten, L.E.M.; Dijkstra, G.; Woude, C.J. van der; Roelen, D.L.; Zwaginga, J.J.; Verspaget, H.W.; Fibbe, W.E.; Hommes, D.W.; Peeters, K.C.M.J. & Meulen-de Jong, A.E. van der (2020), Long-term evaluation of allogeneic bone marrow-derived mesenchymal stromal cell therapy for Crohn's disease perianal fistulas, Journal of Crohn's and Colitis 14(1): 64-70.
- Schaapman, J.J.; Amoros, A.; Reijden, J.J. van der; Laleman, W.; Zeuzem, S.; Banares, R.; Jalan, R.; Arroyo, V.; Claria, J.; Verspaget, H.W. & Coenraad, M.J. (2020), Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection, Liver International 40(3).
- Terveer, E.M.; Vendrik, K.E.W.; Ooijevaar, R.E.; Lingen, E. van; Boeije-Koppenol, E.; Nood, E. van; Goorhuis, A.; Bauer, M.P.; Beurden, Y.H. van; Dijkgraaf, M.G.W.; Mulder, C.J.J.; Vandenbroucke-Grauls, C.M.J.E.; Seegers, J.F.M.L.; Prehn, J. van; Verspaget, H.W.; Kuijper, E.J. & Keller, J.J. (2020), Faecal microbiota transplantation for Clostridioides difficile infection, United European Gastroenterology Journal 8(10): 1236-1247.
- Barnhoorn, M.C.; Plug, L.; Muller-De Jonge, E.S.M.; Molenkamp, D.; Bos, E.; Schoonderwoerd, M.J.A.; Corver, W.E.; Meulen-De Jong, A.E. van der; Verspaget, H.W. & Hawinkels, L.J.A.C. (2020), Mesenchymal stromal cell-derived exosomes contribute to epithelial regeneration in experimental inflammatory bowel disease.
- Barnhoorn, M.; Plug, L.; Muller-de Jonge, E.; Bos, E.; Meulen-de Jong, A. van der; Verspaget, H. & Hawinkels, L. (2019), Mesenchymal stromal cell-derived exosomes stimulate epithelial regeneration in vitro and reduce experimental colitis, Journal of Crohn's and Colitis 13: S15-S15.
- Barnhoorn, M.; Schepers, K.; Verspaget, H.; Fibbe, W.; Hawinkels, L.; Pel, M. van & Meulen-de Jong, A. van der (2019), The cytokine milieu in patients with inflammatory bowel disease impacts the phenotype of mesenchymal stromal cells, Journal of Crohn's and Colitis 13: S106-S107.
- Keller, J.J.; Vehreschild, M.J.G.T.; Hvas, C.L.; Jorgensen, S.M.D.; Kupciskas, J.; Link, A.; Mulder, C.J.J.; Goldenberg, S.D.; Arasaradnam, R.; Sokol, H.; Gasbarrini, A.; Hoegenauer, C.; Terveer, E.M.; Kuijper, E.J.; Arkkila, P.; Gasbarrini, A.; Gridnyev, O.; Megraud, F.; Kump, P.K.; Nakov, R.; Goldenberg, S.D.; Satokari, R.; Tkatch, S.; Sanguinetti, M.; Sokol, H.; Cammarota, G.; Dorofeev, A.; Keller, J.J.; Hoegenauer, C.; Gubska, O.; Ianiro, G.; Mattila, E.; Ooijevaar, R.E.; Arasaradnam, R.; Sarin, S.K.; Sood, A.; Putignani, L.; Alric, L.; Arkkila, P.; Hvas, C.L.; Jorgensen, S.M.D.; Kuijper, E.J.; Kupciskas, J.; Link, A.; Mulder, C.J.J.; Williams, H.R.T.; Goorhuis, A.; Verspaget, H.W.; Terveer, E.M.; Hold, G.L.; Tilg, H.; Ponsioen, C.Y. & Standards Guidelines Initiative (2019), Stool for fecal microbiota transplantation should be classified as a transplant product and not as a drug.
- Schaapman, J.; Alex, A.; Reijden, J. van der; Laleman, W.; Zeuzem, S.; Banares, R.; Jalan, R.; Arroyo, V.; Verspaget, H.W. & Coenraad, M. (2019), Genetic variants of innate immunity receptors are associated with mortality but not with bacterial infections in liver cirrhosis, Journal of Hepatology 70(1): E182-E182.
- Ooijevaar, R.E.; Terveer, E.M.; Verspaget, H.W.; Kuijper, E.J.; Keller, J.J. & Klotman, M.E. (2019), Clinical Application and Potential of Fecal Microbiota Transplantation, Annual Review of Medicine 70: 335-351.
- Barnhoorn, M.C.; Halteren, A.G.S. van; Pel, M. van; Molendijk, I.; Struijk, A.C.; Jansen, P.M.; Verspaget, H.W.; Dijkstra, G.; Oosten, L.E.M. & Meulen-de Jong, A.E. van der (2019), Lymphoproliferative Disease in the Rectum 4 Years After Local Mesenchymal Stromal Cell Therapy for Refractory Perianal Crohn's Fistulas: A Case Report, Journal of Crohn's and Colitis 13(6): 807-811.
- Helm, D. van der; Barnhoorn, M.C.; Jonge-Muller, E.S.M. de; Molendijk, I.; Hawinkels, L.J.A.C.; Coenraad, M.J.; Hoek, B. van & Verspaget, H.W. (2019), Local but not systemic administration of mesenchymal stromal cells ameliorates fibrogenesis in regenerating livers, Journal of Cellular and Molecular Medicine 23(9): 6238-6250.
- Barnhoorn, M.; Jonge-Muller, E. de; Molendijk, I.; Gulijk, M. van; Lebbink, O.; Janson, S.; Schoonderwoerd, M.; Helm, D. van der; Meulen-de Jong, A. van der; Hawinkels, L. & Verspaget, H. (2018), Endoscopic Administration of Mesenchymal Stromal Cells Reduces Inflammation in Experimental Colitis, Inflammatory Bowel Diseases 24(8): 1755-1767.
- Karkampouna, S.; Helm, D. van der; Gray, P.C.; Chen, L.P.; Klima, I.; Grosjean, J.; Burgmans, M.C.; Farina-Sarasqueta, A.; Snaar-Jagalska, E.B.; Stroka, D.M.; Terracciano, L.; Hoek, B. van; Schaapherder, A.F.; Osanto, S.; Thalmann, G.N.; Verspaget, H.W.; Coenraad, M.J. & Kruithof-de Julio, M. (2018), CRIPTO promotes an aggressive tumour phenotype and resistance to treatment in hepatocellular carcinoma, Journal of Pathology 245(3): 297-310.
- Helm, D. van der; Groenewoud, A.; Jonge-Muller, E.S.M. de; Barnhoorn, M.C.; Schoonderwoerd, M.J.A.; Coenraad, M.J.; Hawinkels, L.J.A.C.; Snaar-Jagalska, B.E.; Hoek, B. van & Verspaget, H.W. (2018), Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model, Scientific Reports 8.
- Dulk, A.C. den; Shi, X.L.; Verhoeven, C.J.; Dubbeld, J.; Claas, F.H.J.; Wolterbeek, R.; Brand-Schaaf, S.H.; Verspaget, H.W.; Sarasqueta, A.F.; Laan, L.J.W. van der; Metselaar, H.J.; Hoek, B. van; Kwekkeboom, J. & Roelen, D.L. (2018), Donor-specific anti-HLA antibodies are not associated with nonanastomotic biliary strictures but both are independent risk factors for graft loss after liver transplantation, Clinical Transplantation 32(2).
- Kerbert, A.J.C.; Reverter, E.; Verbruggen, L.; Tieleman, M.; Navasa, M.; Mertens, B.J.A.; Rodriguez-Tajes, S.; Vree, M. de; Metselaar, H.J.; Chiang, F.W.T.; Verspaget, H.W.; Hoek, B. van; Bosch, J. & Coenraad, M.J. (2018), Impact of hepatic encephalopathy on liver transplant waiting list mortality in regions with different transplantation rates, Clinical Transplantation 32(11).
- Momozawa, Y.; Dmitrieva, J.; Theatre, E.; Deffontaine, V.; Rahmouni, S.; Charloteaux, B.; Crins, F.; Docampo, E.; Elansary, M.; Gori, A.S.; Lecut, C.; Mariman, R.; Mni, M.; Oury, C.; Altukhov, I.; Alexeev, D.; Aulchenko, Y.; Amininejad, L.; Bouma, G.; Hoentjen, F.; Lowenberg, M.; Oldenburg, B.; Pierik, M.J.; vander Meulen-de Jong, A.E.; Woude, C.J. van der; Visschedijk, M.C.; Lathrop, M.; Hugot, J.P.; Weersma, R.K.; Vos, M. de; Franchimont, D.; Vermeire, S.; Kubo, M.; Louis, E.; Georges, M.; Abraham, C.; Achkar, J.P.; Ahmad, T.; Ananthakrishnan, A.N.; Andersen, V.; Anderson, C.A.; Andrews, J.M.; Annese, V.; Aumais, G.; Baidoo, L.; Baldassano, R.N.; Bampton, P.A.; Barclay, M.; Barrett, J.C.; Bayless, T.M.; Bethge, J.; Bitton, A.; Boucher, G.; Brand, S.; Brandt, B.; Brant, S.R.; Buning, C.; Chew, A.; Cho, J.H.; Cleynen, I.; Cohain, A.; Croft, A.; Daly, M.J.; D'Amato, M.; Danese, S.; Jong, D. de; Denapiene, G.; Denson, L.A.; Devaney, K.L.; Dewit, O.; D'Inca, R.; Dubinsky, M.; Duerr, R.H.; Edwards, C.; Ellinghaus, D.; Essers, J.; Ferguson, L.R.; Festen, E.A.; Fleshner, P.; Florin, T.; Franke, A.; Fransen, K.; Gearry, R.; Gieger, C.; Glas, J.; Goyette, P.; Green, T.; Griffiths, A.M.; Guthery, S.L.; Hakonarson, H.; Halfvarson, J.; Hanigan, K.; Haritunians, T.; Hart, A.; Hawkey, C.; Hayward, N.K.; Hedl, M.; Henderson, P.; Hu, X.H.; Huang, H.L.; Hui, K.Y.; Imielinski, M.; Ippoliti, A.; Jonaitis, L.; Jostins, L.; Karlsen, T.H.; Kennedy, N.A.; Khan, M.A.; Kiudelis, G.; Krishnaprasad, K.; Kugathasan, S.; Kupcinskas, L.; Latiano, A.; Laukens, D.; Lawrance, I.C.; Lee, J.C.; Lees, C.W.; Leja, M.; Limbergen, J. van; Lionetti, P.; Liu, J.Z.; Mahy, G.; Mansfield, J.; Massey, D.; Mathew, C.G.; McGovern, D.P.B.; Milgrom, R.; Mitrovic, M.; Montgomery, G.W.; Mowat, C.; Newman, W.; Ng, A.; Ng, S.C.; Ng, S.M.E.; Nikolaus, S.; Ning, K.; Nothen, M.; Oikonomou, I.; Palmieri, O.; Parkes, M.; Phillips, A.; Ponsioen, C.Y.; Potocnik, U.; Prescott, N.J.; Proctor, D.D.; Radford-Smith, G.; Rahier, J.F.; Raychaudhuri, S.; Regueiro, M.; Rieder, F.; Rioux, J.D.; Ripke, S.; Roberts, R.; Russell, R.K.; Sanderson, J.D.; Sans, M.; Satsangi, J.; Schadt, E.E.; Schreiber, S.; Schulte, D.; Schumm, L.P.; Scott, R.; Seielstad, M.; Sharma, Y.; Silverberg, M.S.; Simms, L.A.; Skieceviciene, J.; Spain, S.L.; Steinhart, A.H.; Stempak, J.M.; Stronati, L.; Sventoraityte, J.; Targan, S.R.; Taylor, K.M.; Velde, A. ter; Torkvist, L.; Tremelling, M.; Sommeren, S. van; Vasiliauskas, E.; Verspaget, H.W.; Walters, T.; Wang, K.; Wang, M.H.; Wei, Z.; Whiteman, D.; Wijmenga, C.; Wilson, D.C.; Winkelmann, J.; Xavier, R.J.; Zhang, B.; Zhang, C.K.; Zhang, H.; Zhang, W.; Zhao, H.Y.; Zhao, Z.Z. & Int IBD Genetics Consortium (2018), IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes, Nature Communications 9.
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- Boonstra, M.C.; Verspaget, H.W.; Ganesh, S.; Kubben, F.J.G.M.; Vahrmeijer, A.L.; Velde, C.J.H.V. de; Kuppen, P.J.K.; Quax, P.H.A. & Sier, C.F.M. (2011), Clinical Applications of the Urokinase Receptor (uPAR) for Cancer Patients, Current Pharmaceutical Design 17(19): 1890-1910.
- Hoboken, E.A. van; Thijssen, A.Y.; Verhaaren, R.; Veek, P.P.J. van der; Prins, F.A.; Verspaget, H.W. & Masclee, A.A.M. (2011), Symptoms in patients with ulcerative colitis in remission are associated with visceral hypersensitivity and mast cell activity, Scandinavian Journal of Gastroenterology 46(7-8): 981-987.
- Anderson, C.A.; Boucher, G.; Lees, C.W.; Franke, A.; D'Amato, M.; Taylor, K.D.; Lee, J.C.; Goyette, P.; Imielinski, M.; Latiano, A.; Lagace, C.; Scott, R.; Amininejad, L.; Bumpstead, S.; Baidoo, L.; Baldassano, R.N.; Barclay, M.; Bayless, T.M.; Brand, S.; Buning, C.; Colombel, J.F.; Denson, L.A.; Vos, M. de; Dubinsky, M.; Edwards, C.; Ellinghaus, D.; Fehrmann, R.S.N.; Floyd, J.A.B.; Florin, T.; Franchimont, D.; Franke, L.; Georges, M.; Glas, J.; Glazer, N.L.; Guthery, S.L.; Haritunians, T.; Hayward, N.K.; Hugot, J.P.; Jobin, G.; Laukens, D.; Lawrance, I.; Lemann, M.; Levine, A.; Libioulle, C.; Louis, E.; McGovern, D.P.; Milla, M.; Montgomery, G.W.; Morley, K.I.; Mowat, C.; Ng, A.; Newman, W.; Ophoff, R.A.; Papi, L.; Palmieri, O.; Peyrin-Biroulet, L.; Panes, J.; Phillips, A.; Prescott, N.J.; Proctor, D.D.; Roberts, R.; Russell, R.; Rutgeerts, P.; Sanderson, J.; Sans, M.; Schumm, P.; Seibold, F.; Sharma, Y.; Simms, L.A.; Seielstad, M.; Steinhart, A.H.; Targan, S.R.; Berg, L.H. van den; Vatn, M.; Verspaget, H.; Walters, T.; Wijmenga, C.; Wilson, D.C.; Westra, H.J.; Xavier, R.J.; Zhao, Z.Z.; Ponsioen, C.Y.; Andersen, V.; Torkvist, L.; Gazouli, M.; Anagnou, N.P.; Karlsen, T.H.; Kupcinskas, L.; Sventoraityte, J.; Mansfield, J.C.; Kugathasan, S.; Silverberg, M.S.; Halfvarson, J.; Rotter, J.I.; Mathew, C.G.; Griffiths, A.M.; Gearry, R.; Ahmad, T.; Brant, S.R.; Chamaillard, M.; Satsangi, J.; Cho, J.H.; Schreiber, S.; Daly, M.J.; Barrett, J.C.; Parkes, M.; Annese, V.; Hakonarson, H.; Radford-Smith, G.; Duerr, R.H.; Vermeire, S.; Weersma, R.K. & Rioux, J.D. (2011), Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47, Nature Genetics 43(3): 246U94.
- Duijvestein, M.; Molendijk, I.; Roelofs, H.; Vos, A.C.W.; Verhaar, A.P.; Reinders, M.E.J.; Fibbe, W.E.; Verspaget, H.W.; Brink, G.R. van den; Wildenberg, M.E. & Hommes, D.W. (2011), Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease, Cytotherapy 13(9): 1066-1073.
- Rooij, B.J.F. de; Beek, M.T. van der; Hoek, B. van; Vossen, A.C.T.M.; Hove, W.R. ten; Roos, A.; Schaapherder, A.F.; Porte, R.J.; Reijden, J.J. van der; Coenraad, M.J.; Hommes, D.W. & Verspaget, H.W. (2011), Mannose-binding lectin and Ficolin-2 gene polymorphisms predispose to cytomegalovirus (re)infection after orthotopic liver transplantation, Journal of Hepatology 55(4): 800-807.
- Kuiper, P.; Hawinkels, L.J.A.C.; Jonge-Muller, E.S.M. de; Biemond, I.; Lamers, C.B.H.W. & Verspaget, H.W. (2011), Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors, World Journal of Gastroenterology 17(2): 219-225.
- Kuiper, P.; Verspaget, H.W.; Biemond, I.; Jonge-Muller, E.S. de; Eeden, S. van; Velthuysen, M.L.F. van; Taal, B.G. & Lamers, C.B. (2011), Expression and ligand binding of bombesin receptors in pulmonary and intestinal carcinoids, Journal of Endocrinological Investigation 34(9): 665-670.
- Kodach, L.L.; Jacobs, R.J.; Voorneveld, P.W.; Wildenberg, M.E.; Verspaget, H.W.; Wezel, T. van; Morreau, H.; Hommes, D.W.; Peppelenbosch, M.P.; Brink, G.R. van den & Hardwick, J.C.H. (2011), Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway, Gut 60(11): 1544-1553.
- Duijvestein, M.; Wildenberg, M.E.; Welling, M.M.; Hennink, S.; Molendijk, I.; Zuylen, V.L. van; Bosse, T.; Vos, A.C.W.; Jonge-Muller, E.S.M. de; Roelofs, H.; Weerd, L. van der; Verspaget, H.W.; Fibbe, W.E.; Velde, A.A.T.; Brink, G.R. van den & Hommes, D.W. (2011), Pretreatment with Interferon-gamma Enhances the Therapeutic Activity of Mesenchymal Stromal Cells in Animal Models of Colitis, STEM CELLS 29(10): 1549-1558.
- Nijmeijer, R.M.; Gadaleta, R.M.; Mil, S.W.C. van; Bodegraven, A.A. van; Crusius, J.B.A.; Dijkstra, G.; Hommes, D.W.; Jong, D.J. de; Stokkers, P.C.F.; Verspaget, H.W.; Weersma, R.K.; Woude, C.J. van der; Stapelbroek, J.M.; Schipper, M.E.I.; Wijmenga, C.; Erpecum, K.J. van; Oldenburg, B. & Dutch Initiative Crohn (2011), Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease, PLoS ONE 6(8).
- Marel, S. van der; Comijn, E.M.; Verspaget, H.W.; Deventer, S. van; Brink, G.R. van den; Petry, H.; Hommes, D.W. & Ferreira, V. (2011), Neutralizing Antibodies Against Adeno-associated Viruses in Inflammatory Bowel Disease Patients: Implications for Gene Therapy, Inflammatory Bowel Diseases 17(12): 2436-2442.
- Hove, W.R. ten; Korkmaz, K.S.; Dries, S.O. den; Rooij, B.J.F. de; Hoek, B. van; Porte, R.J.; Reijden, J.J. van der; Coenraad, M.J.; Dubbeld, J.; Hommes, D.W. & Verspaget, H.W. (2011), Matrix metalloproteinase 2 genotype is associated with nonanastomotic biliary strictures after orthotopic liver transplantation.
- Rivas, M.A.; Beaudoin, M.; Gardet, A.; Stevens, C.; Sharma, Y.; Zhang, C.K.; Boucher, G.; Ripke, S.; Ellinghaus, D.; Burtt, N.; Fennell, T.; Kirby, A.; Latiano, A.; Goyette, P.; Green, T.; Halfvarson, J.; Haritunians, T.; Korn, J.M.; Kuruvilla, F.; Lagace, C.; Neale, B.; , K.S. lo; Schumm, P.; Torkvist, L.; Dubinsky, M.C.; Brant, S.R.; Silverberg, M.S.; Duerr, R.H.; Altshuler, D.; Gabriel, S.; Lettre, G.; Franke, A.; D'Amato, M.; McGovern, D.P.B.; Cho, J.H.; Rioux, J.D.; Xavier, R.J.; Daly, M.J.; Natl Inst Diabet Digestive Kidney; United Kingdom Inflammatory Bowel & Int Inflammatory Bowel Dis (2011), Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease, Nature Genetics 43(11): 1066-U50.
- Kuiper, P.; Verspaget, H.W.; Overbeek, L.I.H.; Biemond, I. & Lamers, C.B. (2011), An overview of the current diagnosis and recent developments in neuroendocrine tumours of the gastroenteropancreatic tract: the diagnostic approach, Netherlands Journal of Medicine 69(1): 14-20.
- Robanus-Maandag, E.C.; Koelink, P.J.; Breukel, C.; Salvatori, D.C.F.; Jagmohan-Changur, S.C.; Bosch, C.A.J.; Verspaget, H.W.; Devilee, P.; Fodde, R. & Smits, R. (2010), A new conditional Apc-mutant mouse model for colorectal cancer, Carcinogenesis 31(5): 946-952.
- Koelink, P.J.; Hawinkels, L.J.A.C.; Wiercinska, E.; Sier, C.F.M.; Dijke, P. ten; Lamers, C.B.H.W.; Hommes, D.W. & Verspaget, H.W. (2010), 5-Aminosalicylic acid inhibits TGF-beta 1 signalling in colorectal cancer cells.
- Kuiper, P.; Verspaget, H.W.; Slooten, H.J. van; Overbeek, L.; Biemond, I. & Lamers, C.B. (2010), Pathological Incidence of Duodenopancreatic Neuroendocrine Tumors in The Netherlands A Pathologisch Anatomisch Landelijk Geautomatiseerd Archief Study, Pancreas 39(8): 1134-1139.
- Hawinkels, L.J.A.C.; Kuiper, P.; Wiercinska, E.; Verspaget, H.W.; Liu, Z.; Pardali, E.; Sier, C.F.M. & Dijke, P. ten (2010), Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis, Cancer Research 70(10): 4141-4150.
- Kodach, L.L.; Jacobs, R.J.; Heijmans, J.; Noesel, C.J.M. van; Langers, A.M.J.; Verspaget, H.W.; Hommes, D.W.; Offerhaus, G.J.A.; Brink, G.R. van den & Hardwick, J.C.H. (2010), The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer, Carcinogenesis 31(9): 1567-1575.
- Kuiper, P.; Biemond, I.; Masclee, A.A.; Jansen, J.B.; Verspaget, H.W. & Lamers, C.B. (2010), Diagnostic Efficacy of the Secretin Stimulation Test for the Zollinger-Ellison Syndrome: An Intra-Individual Comparison Using Different Dosages in Patients and Controls, Pancreatology 10(1): 14-18.
- Franke, A.; McGovern, D.P.B.; Barrett, J.C.; Wang, K.; Radford-Smith, G.L.; Ahmad, T.; Lees, C.W.; Balschun, T.; Lee, J.; Roberts, R.; Anderson, C.A.; Bis, J.C.; Bumpstead, S.; Ellinghaus, D.; Festen, E.M.; Georges, M.; Green, T.; Haritunians, T.; Jostins, L.; Latiano, A.; Mathew, C.G.; Montgomery, G.W.; Prescott, N.J.; Raychaudhuri, S.; Rotter, J.I.; Schumm, P.; Sharma, Y.; Simms, L.A.; Taylor, K.D.; Whiteman, D.; Wijmenga, C.; Baldassano, R.N.; Barclay, M.; Bayless, T.M.; Brand, S.; Buning, C.; Cohen, A.; Colombel, J.F.; Cottone, M.; Stronati, L.; Denson, T.; Vos, M. de; D'Inca, R.; Dubinsky, M.; Edwards, C.; Florin, T.; Franchimont, D.; Gearry, R.; Glas, J.; Gossum, A. van; Guthery, S.L.; Halfvarson, J.; Verspaget, H.W.; Hugot, J.P.; Karban, A.; Laukens, D.; Lawrance, I.; Lemann, M.; Levine, A.; Libioulle, C.; Louis, E.; Mowat, C.; Newman, W.; Panes, J.; Phillips, A.; Proctor, D.D.; Regueiro, M.; Russell, R.; Rutgeerts, P.; Sanderson, J.; Sans, M.; Seibold, F.; Steinhart, A.H.; Stokkers, P.C.F.; Torkvist, L.; Kullak-Ublick, G.; Wilson, D.; Walters, T.; Targan, S.R.; Brant, S.R.; Rioux, J.D.; D'Amato, M.; Weersma, R.K.; Kugathasan, S.; Griffiths, A.M.; Mansfield, J.C.; Vermeire, S.; Duerr, R.H.; Silverberg, M.S.; Satsangi, J.; Schreiber, S.; Cho, J.H.; Annese, V.; Hakonarson, H.; Daly, M.J. & Parkes, M. (2010), Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci, Nature Genetics 42(12): 1118U121.
- Rooij, B.J.F. de; Hoek, B. van; Hove, W.R. ten; Roos, A.; Bouwman, L.H.; Schaapherder, A.F.; Porte, R.J.; Daha, M.R.; Reijden, J.J. van der; Coenraad, M.J.; Ringers, J.; Baranski, A.G.; Hepkema, B.G.; Hommes, D.W. & Verspaget, H.W. (2010), Lectin Complement Pathway Gene Profile of Donor and Recipient Determine the Risk of Bacterial Infections After Orthotopic Liver Transplantation, Hepatology 52(3): 1100-1110.
- Festen, E.A.M.; Stokkers, P.C.F.; Diemen, C.C. van; Bodegraven, A.A. van; Boezen, H.M.; Crusius, B.J.A.; Hommes, D.W.; Woude, J.C. van der; Balschun, T.; Verspaget, H.W.; Schreiber, S.; Jong, D.J. de; Franke, A.; Dijkstra, G.; Wijmenga, C. & Weersma, R.K. (2010), Genetic Analysis in A Dutch Study Sample Identifies More Ulcerative Colitis Susceptibility Loci and Shows Their Additive Role in Disease Risk, American Journal of Gastroenterology 105(2): 395-402.
- Koelink, P.J.; Mieremet-Ooms, M.A.C.; Corver, W.E.; Wolanin, K.; Hommes, D.W.; Lamers, C.B.H.W. & Verspaget, H.W. (2010), 5-Aminosalicylic Acid Interferes in the Cell Cycle of Colorectal Cancer Cells and Induces Cell Death Modes, Inflammatory Bowel Diseases 16(3): 379-389.
- Duijvestein, M.; Vos, A.C.W.; Roelofs, H.; Wildenberg, M.E.; Wendrich, B.B.; Verspaget, H.W.; Kooy-Winkelaar, E.M.C.; Koning, F.; Zwaginga, J.J.; Fidder, H.H.; Verhaar, A.P.; Fibbe, W.E.; Brink, G.R. van den & Hommes, D.W. (2010), Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study, Gut 59(12): 1662-1669.
- Meijer MJ, Mieremet-Ooms MAC, Sier CFM, van Hogezand RA, Lamers CBHW, Hommes DW & Verspaget HW (2009), Matrix Metalloproteinases and Their Tissue Inhibitors as Prognostic Indicators for Diagnostic and Surgical Recurrence in Crohn's Disease, Inflammatory Bowel Diseases 15(1): 84-92.
- Weersma RK, Stokkers PCF, van Bodegraven AA, van Hogezand RA, Verspaget HW, de Jong DJ, van der Woude CJ, Oldenburg B, Linskens RK & Festen EAM (2009), Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort, Gut 58(3): 388-395.
- Koelink PJ, Sier CFM, Hommes DW, Lamers CBHW & Verspaget HW (2009), Clinical significance of stromal apoptosis in colorectal cancer, British Journal of Cancer 101(5): 765-773.
- Koelink PJ, Lamers CBHW, Hommes DW & Verspaget HW (2009), Circulating cell death products predict clinical outcome of colorectal cancer patients, BMC Cancer 9.
- Dahlke MH, Hoogduijn M, Eggenhofer E, Popp FC, Renner P, Slowik P, Rosenauer A, Piso P, Geissler EK, Lange C, Chabannes D, Mazzanti B, Bigenzahn S, Bertolino P, Kunter U, Introna M, Rambaldi A, Capelli C, Perico N & Casiraghi F (2009), Toward MSC in Solid Organ Transplantation: 2008 Position Paper of the MISOT Study Group, Transplantation 88(5): 614-619.
- Andersen CL, Christensen LL, Thorsen K, Schepeler T, Sorensen FB, Verspaget HW, Simon R, Kruhoffer M, Aaltonen LA & Laurberg S (2009), Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer, British Journal of Cancer 100(3): 511-523.
- Hawinkels LJAC, Verspaget HW, van der Reijden JJ, van der Zon JM, Verheijen JH, Hommes DW, Lamers CBHW & Sier CFM (2009), Active TGF-beta 1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence, Cancer Science 100(4): 663-670.
- Koelink PJ, Robanus-Maandag EC, Devilee P, Hommes DW, Lamers CBHW & Verspaget HW (2009), 5-Aminosalicylic acid inhibits colitis-associated but not sporadic colorectal neoplasia in a novel conditional Apc mouse model, Carcinogenesis 30(7): 1217-1224.
- Langers AMJ, Sier CFM, Hawinkels LJAC, Kubben FJGM, van Duijn W, van der Reijden JJ, Lamers CBHW, Hommes DW & Verspaget HW (2008), MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not, British Journal of Cancer 98(11).
- Hawinkels LJAC, Zuidwijk K, Verspaget HW, de Jonge-Muller ESM, van Duijn W, Ferreira V, Fontijn RD, David G, Hommes DW, Lamers CBHW & Sier CFM (2008), VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis, European Journal of Cancer 44(13).
- Hawinkels LJ, Zuidwijk K, Verspaget HW, de Jonge-Muller ES, van Duijn W, Ferreira V, Fontijn RD, David G, Hommes DW, Lamers CB & Sier CF (2008), VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.
- Jorissen RN, Lipton L, Gibbs P, Chapman M, Desai J, Jones IT, Yeatman TJ, East P, Tomlinson IPM, Verspaget HW, Aaltonen LA, Kruhoffer M, Orntoft TF, Andersen CL & Sieber OM (2008), DNA Copy-Number Alterations Underlie Gene Expression Differences between Microsatellite Stable and Unstable Colorectal Cancers, Clinical Cancer Research 14(24): 8061-8069.
- Sier CFM, Hawinkels LJAC, Zijlmans HJMAA, Zuidwijk K, de Jonge-Muller ESM, Ferreira V, Hanemaaijer R, Mulder-Stapel AA, Kenter GG, Verspaget HW & Gorter A (2008), Endothelium specific matrilysin (MMP-7) expression in human cancers, Matrix Biology 27(3).
- Birkenkamp-Demtröder K., Mansilla F., Sørensen F.B., Kruhøffer M., Cabezón T., Christensen L.L., Aaltonen L.A., Verspaget H.W. & Orntoft T.F. (2007), Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro, Molecular Oncology 1(2): 181-195.
- Meijer MJW, Mieremet-Ooms MAC, Hogezand RA, Lamers CBHW, Hommes DW & Verspaget HW (2007), Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease, World Journal of Gastroenterology 13(21).
- Mansilla F, Birkenkamp-Demtroder K, Kruhoffer M, Sorensen FB, Andersen CL, Laiho P, Aaltonen LA, Verspaget HW & Orntoft TF (2007), Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups, British Journal of Cancer 96(12).
- Hawinkels LJAC, Verspaget HW, van den Berg M, Hanemaaijer R & Sier CFM (2007), Determination of matrilysin activity in gastrointestinal neoplasia, European Journal of Clinical Investigation 37(7).
- Meijer MJW, Mieremet-Ooms MAC, van der Zon AM, van Duijn W, van Hogezand RA, Sier CFM, Hommes DW, Lamers CBHW & Verspaget HW (2007), Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype, Digestive and Liver Disease 39(8).
- Kubben FJGM, Sier CFM, Hawinkels LJAC, Tschesche H, van Duijn W, Zuidwijk K, van der Reijden JJ, Hanemaaijer R, Griffioen G, Lamers CBHW & Verspaget HW (2007), Clinical evidence for a protective role of lipocalin-2 against MDAP-9 autodegradation and the impact for gastric cancer, European Journal of Cancer 43(12).
- Hawinkels LJAC, Verspaget HW, van Duijn W, van der Zon JM, Zuidwijk K, Kubben FJGM, Verheijen JH, Hommes DW, Lamers CBHW & Sier CF (2007), Tissue level, activation and cellular localisation of TGF-beta 1 and association with survival in gastric cancer patients, British Journal of Cancer 97(3).
- de Heer P, de Bruin EC, Klein-Kranenbarg E, Aalbers RWM, Marijnen CAM, Putter H, de Bont HJ, Nagelkerke JF, van Krieken JHJM, Verspaget HW, van de Velde CJH & Kuppen PJK (2007), Caspase-3 activity predicts local recurrence in rectal cancer, Clinical Cancer Research 13(19).
- Koelink PJ & Verspaget HW (2007), 5-ASA and colorectal cell-cycle progression, Gastroenterology 132(4).
- Kubben FJGM, Sier CFM, Schram MT, Witte AMC, Veenendaal RA, Van Duijn W, Verheijen JH, Hanemaaijer R, Lamers CBHW & Verspaget HW (2007), Eradication of Helicobacter pylori infection favourably affects altered gastric mucosal MMP-9 levels, Helicobacter 12(5).
- Mourad-Baars PEC, Verspaget HW, Mertens BJA & Mearin ML (2007), Low prevalence of Helicobacter pylori infection in young children in the Netherlands, European Journal of Gastroenterology and Hepatology 19(3).
- Gao Q, Meijer MJW, Schluter UG, van Hogezand RA, van der Zon JM, van den Berg M, van Duijn W, Lamers CBHW & Verspaget HW (2007), Infliximab treatment influences the serological expression of matrix metalloproteinase (MMP)-2 and -9 in Crohn's disease, Inflammatory Bowel Diseases 13(6).
- Meijer MJ, Mieremet-Ooms MAC, van Duijn W, van der Zon AM, Hanemaaijer R, Verheijen JH, van Hogezand RA, Lamers CBHW & Verspaget HW (2007), Effect of the anti-tumor necrosis factor-alpha antibody infliximab on the ex vivo mucosal matrix metalloproteinase-proteolytic phenotype in inflammatory bowel disease, Inflammatory Bowel Diseases 13(2).
- ten Hove WR, Verspaget HW, Barge R, Lamers CB & van Hoek B (2007), Liver chimerism after allogeneic blood stem cell transplantation, Transplantation Proceedings 39(1).
- Birkenkamp-Demtroder K, Mansilla F, Sorensen FB, Kruhoffer M, Cabezon T, Christensen LL, Aaltonen LA, Verspaget HW & Orntoft TF (2007), Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro, Molecular Oncology 1(2): 181-195.
- Roos A, Bouwman LH, Terpstra OT, de Knijff P, van Hoek B, Verspaget HW, Berger SP, Daha MR, Frolich M, van der Slik AR, Doxiadis II, Roep BO & Schaapherder AFM (2006), Mannose-binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation, Molecular Immunology 43(1-2).
- Vollaard AM, Verspaget HW, Ali S, Visser LG, Veenendaal RA, Van Asten HAGH, Widjaja S, Surjadi C & Van Dissel JT (2006), Helicobacter pylori infection and typhoid fever in Jakarta, Indonesia, Epidemiology and Infection 134(1).
- Kubben FJGM, Sier CFM, van Duijn W, Griffioen G, Hanemaaijer R, van de Velde CJH, van Krieken JHJM, Lamers CBHW & Verspaget HW (2006), Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer, British Journal of Cancer 94(7).
- Kubben FJJM, Sier CFM, Meijer MJW, van den Berg M, van der Reijden JJ, Griffioen G, van de Velde CJH, Lamers CBHW & Verspaget HW (2006), Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer, British Journal of Cancer 95(6).
- Bouwman LH, Roos A, Terpstra OT, De Knijff P, Van Hoek B, Verspaget HW, Berger SP, Daha MR, Frolich M, Van Der Slik AR, Doxiadis II, Roep BO & Schaapherder AFM (2005), Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation, Gastroenterology 129(2).
- Verspaget HW, Kuyvenhoven JP & van Hoek B (2005), Preanalytical conditions and circulating matrix metalloproteinases, Transplantation 79(6).
- van der Veek PPJ, van den Berg M, de Kroon YE, Verspaget HW & Masclee AAM (2005), Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome, American Journal of Gastroenterology 100(11).
- Gao Q, Meijer MJW, Kubben FJGM, Sier CFM, Kruidenier L, van Duijn W, van den Berg M, van Hogezand RA, Lamers CBHW & Verspaget HW (2005), Expression of matrix metalloproteinases-2 and-9 in intestinal tissue of patients with inflammatory bowel diseases, Digestive and Liver Disease 37(8).
- Bouwman LH, Terpstra OT, Schaapherder AFM, Roos A, Berger SP, Daha MR, De Knijff P, Van Hoek B, Verspaget HW, Frolich M, Van der Slik AR, Doxiadis II & Roep BO (2005), Mannose-binding lectin and liver transplantation - Reply, Gastroenterology 129(5).
- Gao Q, Van Hogezand RA, Lamers CBHW & Verspaget HW (2004), Basic fibroblast growth factor as a response parameter to infliximab in fistulizing Crohn's disease, Alimentary Pharmacology and Therapeutics 20(5).
- Kuyvenhoven JP, Molenaar IQ, Verspaget HW, Veldman MG, Palareti G, Legnani C, Moolenburgh SE, Terpstra O, Lamers CBHW, van Hoek B & Porte RJ (2004), Plasma MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 during human orthotopic liver transplantation - The effect of aprotinin and the relation to ischemia/reperfusion injury, Thrombosis and Haemostasis 91(3).
- Kuyvenhoven JP, Verspaget HW, Gao Q, Ringers J, Smit VTHBM, Lamers CBHW & Van Hoek B (2004), Assessment of serum matrix metalloproteinases MMP-2 and MMP-9 after human liver transplantation: Increased serum MMP-9 level in acute rejection, Transplantation 77(11).
- Kruidenier L, Kuiper I, van Duijn W, Marklund SL, van Hogezand RA, Lamers CBHW & Verspaget HW (2003), Differential mucosal expression of three superoxide dismutase isoforms in inflammatory bowel disease, Journal of Pathology 201(1).
- Kruidenier L, Kuiper I, van Duijn W, Mieremet-Ooms MAC, van Hogezand RA, Lamers CBHW & Verspaget HW (2003), Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease, Journal of Pathology 201(1).
- Kuyvenhoven JP, van Hoek B, Blom E, van Duijn W, Hanemaaijer R, Verheijen JH, Lamers CBHW & Verspaget HW (2003), Assessment of the clinical significance of serum matrix metalloproteinases MMP-2 and MMP-9 in patients with various chronic liver diseases and hepatocellular carcinoma, Thrombosis and Haemostasis 89(4).
- Kruidenier L, Kulper I, Lamers CBHW & Verspaget HW (2003), Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants, Journal of Pathology 201(1).
- Kuyvenhoven JP, Ringers J, Verspaget HW, Lamers CBHW & van Hoek B (2003), Serum matrix metalloproteinase MMP-2 and MMP-9 in the late phase of ischemia and reperfusion injury in human orthotopic liver transplantation, Transplantation Proceedings 35(8).
- Kruidenier L, Van Meeteren ME, Kuiper I, Jaarsma D, Lamers CBHW, Zijlstra FJ & Verspaget HW (2003), Attenuated mild colonic inflammation and improved survival from severe DSS-colitis of transgenic Cu/Zn-SOD mice, Free Radical Biology and Medicine 34(6).
- Mourad-Baars PEC, Verspaget HW, Verhoeff JDBM, Mertens BJA, Verloove-Vanhorick PS & Mearin LM (2002), The prevalence of Helicobacter pylori (Hp) infection in young children in the Netherlands, Gut 51.
- Janssen AML, van Duijn W, Kubben FJGM, Griffioen G, Lamers CBHW, van Krieken JHJM, van de Velde CJH & Verspaget HW (2002), Prognostic significance of metallothionein in human gastrointestinal cancer, Clinical Cancer Research 8(6).
- Kruidenier L & Verspaget HW (2002), Review article: oxidative stress as a pathogenic factor in inflammatory bowel disease - radicals or ridiculous?, Alimentary Pharmacology and Therapeutics 16(12).
- Verspaget HW, van der Zon AM, Gao Q & van Hogezand RA (2001), Infliximab for Crohn's disease, Alimentary Pharmacology and Therapeutics 15(12).
- Jaarsma D, Rognoni F, van Duijn W, Verspaget HW, Haasdijk ED & Holstege JC (2001), CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations, Acta Neuropathologica 102(4).
- Wagtmans MJ, Verspaget HW, Lamers CBHW & van Hogezand RA (2001), Gender-related differences in the clinical course of Crohn's disease, American Journal of Gastroenterology 96(5).
- Janssen AML, Bosman CB, van Duijn W, Oostendorp-van de Ruit MM, Kubben FJGM, Griffioen G, Lamers CBHW, van Krieken JHJM, van de Velde CJH & Verspaget HW (2000), Superoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer.
- Janssen AML, van Duijn W, Oostendorp-van de Ruit MM, Kruidenier L, Bosman CB, Griffioen G, Lamers CBHW, van Krieken JHJM, van de Velde CJH & Verspaget HW (2000), Metallothionein in human gastrointestinal cancer, Journal of Pathology 192(3).
- Wrigley E, Verspaget HW, Jayson GC & McGown AT (2000), Metallothionein expression in epithelial ovarian cancer: effect of chemotherapy and prognostic significance, Journal of Cancer Research and Clinical Oncology 126(12).
- Bus PJ, Verspaget HW, Lamers CBHW & Griffioen G (2000), Chemoprevention of colorectal cancer by non-steroidal anti-inflammatory drugs, Scandinavian Journal of Gastroenterology 35.
- Smoot DT, Elliott TB, Verspaget HW, Jones D, Allen CR, Vernon KG, Bremner T, Kidd LR, Kim GS, Groupman JD & Ashktorab H (2000), Influence of Helicobacter pylori on reactive oxygen-induced gastric epithelial cell injury, Carcinogenesis 21(11).
- Jaarsma D, Haasdijk ED, Grashorn JAC, Hawkins R, van Duijn W, Verspaget HW, London J & Holstege JC (2000), Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1, Neurobiology of Disease 7(6).
- Bestuurslid
- Landelijk biobankcoördinator en lid Centraal team
- Lid VENI-selectiecommissie