Eline Slagboom
Hoogleraar Moleculaire Epidemiologie
- Naam
- Prof.dr. P. Slagboom
- Telefoon
- +31 71 526 9731
- p.slagboom@lumc.nl
- ORCID iD
- 0000-0002-2875-4723
P. Eline Slagboom is bioloog, verouderingsonderzoeker en professor in de moleculaire epidemiologie, hoofd van de gelijknamige sectie en van de afdeling ‘Biomedical Data Sciences’. Ze is voorzitter van het LUMC Thema Lifecourse Epidemiology and Geroscience (LEGend) en van de Dutch Society for Research on Ageing. Ze is lid van de Koninklijke Nederlandse Akademie van Wetenschappen, Fellow bij het Max Planck Instituut voor de Biologie van Veroudering in Keulen, en Medical Delta hoogleraar aan de Technische Universiteit Delft. Ze is mede oprichter van de biobanken consortia BBMRI-NL (Biobanking and Biomolecular Resources Research Infrastructure) en NCC (Netherlands Cohort Consortium), oprichter van het Leiden LangLeven Studie cohort en ze heeft het nationale metabolomics onderzoek geleid binnen BBMRI.
Meer informatie over Eline Slagboom
P. Eline Slagboom is bioloog, verouderingsonderzoeker en professor in de moleculaire epidemiologie, hoofd van de gelijknamige sectie en van de afdeling ‘Biomedical Data Sciences’. Ze is voorzitter van het LUMC Thema Lifecourse Epidemiology and Geroscience (LEGend) en van de Dutch Society for Research on Ageing. Ze is lid van de Koninklijke Nederlandse Akademie van Wetenschappen, Fellow bij het Max Planck Instituut voor de Biologie van Veroudering in Keulen, en Medical Delta hoogleraar aan de Technische Universiteit Delft. Ze is mede oprichter van de biobanken consortia BBMRI-NL (Biobanking and Biomolecular Resources Research Infrastructure) en NCC (Netherlands Cohort Consortium), oprichter van het Leiden LangLeven Studie cohort en ze heeft het nationale metabolomics onderzoek geleid binnen BBMRI.
Moleculaire Epidemiologie
In de afgelopen 25 jaar ben ik geïnspireerd geweest door het feit dat het verouderingsproces de basis vormt van de meest frequente ziekten, tussen mensen zeer verschillend verloopt en te modificeren is. In de sectie worden drie thema’s onderzocht vanuit een moleculair, cellulair en epidemiologisch perspectief: veroudering, artrose en het epigenoom. Mijn groep bestudeert 1) de etiologie van veroudering en familiaire langlevendheid door genetische en functionele genomische studies; 2) de ontwikkeling van moleculaire biomarkers voor biologische leeftijd/fysiologische kwetsbaarheid; en 3) de immuun-metabole reacties van ouderen op leefstijlinterventies. Ons muli-omics onderzoek in deze studies heeft een sterke datawetenschappelijke component. Implementatie strategieën worden opgezet in de Medical Delta met de Health Campus Den Haag.
Ik geef met passie les aan jong en oud en heb een trainingsprogramma ontwikkeld om creatief en logisch denken in de wetenschap te stimuleren bij middelbare school leerlingen en hun leraren. Deze training geef ik ook aan studenten in de LUMC Master Vitality and Ageing.
Wetenschappelijke carrière
Professor P. Eline Slagboom rondde de studie biologie af in 1985 in Leiden en promoveerde op 30-11-1993 op haar proefschrift getiteld ‘Genomic instability and aging”. Tussen ’93 en 2000 was zij groepsleider bij het TNO Gaubius Instituut en werd in 2000 benoemd tot hoogleraar in de Moleculaire Epidemiologie bij het Leids Universitair Medisch Centrum. Haar inauguratie vond plaats op 21-03-2003 en de oratie was getiteld: ‘Van het concert des levens…’
Slagboom trok veel getalenteerde onderzoekers aan en haar groep groeide aanzienlijk over de jaren door verworven subsidies en samenwerking met de industrie. De grootste projecten die zij coördineerde betroffen een grootschalig FP-7 EU project (IDEAL: Integrated research on DEvelopmental determinants of Aging and Longevity). Nu leidt ze VOILA (Vitality Oriented Innovations for the Lifecourse of the Ageing Society), het grootste publiek-private initiatief m.b.t. veroudering in Nederland.
Prijzen en eervolle benoemingen
- Designers and Artists 4 Genomics Award (2011).
- Benoemd als Fellow bij het Max Planck Instituut voor de Biologie van Veroudering in Keulen, Duitsland
- KNAW lid
- Schober Award 2021 (10th International meeting on Aging, University Hospital Halle (Saale) - Germany)
Hoogleraar Moleculaire Epidemiologie
- Faculteit Geneeskunde
- Divisie 4
- Biomedical Data Sciences
- Moleculaire Epidemiologie
- Valeanu, A.; Margina, D.; Weber, D.; Stuetz, W.; Moreno-Villanueva, M.; Dollé, M.E.T.; Jansen, E.H.J.M.; Gonos, E.S.; Bernhardt, J.; Grubeck-Loebenstein, B.; Weinberger, B.; Fiegl, S.; Sikora, E.; Mosieniak, G.; Toussaint, O.; Debacq-Chainiaux, F.; Capri, M.; Garagnani, P.; Pirazzini, C.; Bacalini, M.G.; Hervonen, A.; Slagboom, P.E.; Talbot, D.; Breusing, N.; Frank, J.; Bürkle, A.; Franceschi, C.; Grune, T. & Gradinaru, D. (2024), Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data, Mechanisms of Ageing and Development 222.
- Luna, J.L. de; Nounu, A.; Neumeyer, S.; Sinke, L.; Wilson, R.; Hellbach, F.; Matías-García, P.R.; Delerue, T.; Winkelmann, J.; Peters, A.; Thorand, B.; Beekman, M.; Heijmans, B.T.; Slagboom, E.; Gieger, C.; Linseisen, J. & Waldenberger, M. (2024), Epigenome-wide association study of dietary fatty acid intake, Clinical Epigenetics 16(1).
- Moqri, M.; Herzog, C.; Poganik, J.R.; Ying, K.J.; Justice, J.N.; Belsky, D.W.; Higgins-Chen, A.T.; Chen, B.H.; Cohen, A.A.; Fuellen, G.; Haegg, S.; Marioni, R.E.; Widschwendter, M.; Fortney, K.; Fedichev, P.O.; Zhavoronkov, A.; Barzilai, N.; Lasky-Su, J.; Kiel, D.P.; Kennedy, B.K.; Cummings, S.; Slagboom, P.E.; Verdin, E.; Maier, A.B.; Sebastiano, V.; Snyder, M.P.; Gladyshev, V.N.; Horvath, S. & Ferrucci, L. (2024), Validation of biomarkers of aging, Nature Medicine.
- Jia, X.Q.; Fan, J.Y.; Wu, X.C.; Cao, X.Q.; Ma, L.N.; Abdelrahman, Z.; Zhao, F.; Zhu, H.T.; Bizzarri, D.; Akker, E.B. van den; Slagboom, P.E.; Deelen, J.; Zhou, D. & Liu, Z.Y. (2024), A novel metabolomic aging clock predicting health outcomes and its genetic and modifiable factors, Advanced Science.
- Herzog, C.M.S.; Goeminne, L.J.E.; Poganik, J.R.; Barzilai, N.; Belsky, D.W.; Betts-LaCroix, J.; Chen, B.H.; Chen, M.C.L.; Cohen, A.A.; Cummings, S.R.; Fedichev, P.O.; Ferrucci, L.; Fleming, A.; Fortney, K.; Furman, D.; Gorbunova, V.; Higgins-Chen, A.; Hood, L.; Horvath, S.; Justice, J.N.; Kiel, D.P.; Kuchel, G.A.; Lasky-Su, J.; Lebrasseur, N.K.; Maier, A.B.; Schilling, B.; Sebastiano, V.; Slagboom, P.E.; Snyder, M.P.; Verdin, E.; Widschwendter, M.; Zhavoronkov, A.; Moqri, M.; Gladyshev, V.N. & Biomarkers Aging Consortium (2024), Challenges and recommendations for the translation of biomarkers of aging, Nature Aging.
- Twait, E.L.; Kamarioti, M.; Verberk, I.M.W.; Teunissen, C.E.; Nooyens, A.C.J.; Verschuren, W.M.M.; Visser, P.J.; Huisman, M.; Kok, A.A.L.; Slagboom, P.E.; Beekman, M.; Vojinovic, D.; Lakenberg, N.; Ikram, M.A.; Schuurmans, I.K.; Wolters, F.J.; Moonen, J.E.F.; Gerritsen, L.; Flier, W.M. van der; Geerlings, M.I. & NCDC Consortium (2024), Depressive symptoms and plasma markers of Alzheimer's disease and neurodegeneration, American Journal of Geriatric Psychiatry 32(9): 1141-1153.
- Bizzarri, D.; Reinders, M.J.T.; Kuiper, L.; Beekman, M.; Deelen, J.; Meurs, J.B.J.V.; Dongen, J. van; Pool, R.; Ghanbari, M.; Franke, L.; Slagboom, P.E.; Akker, E.B. van den & BBMRI Consortium (2024), NMR metabolomics-guided DNA methylation mortality predictors, EBioMedicine 107.
- Bogaards, F.A.; Gehrmann, T.; Beekman, M.; Lakenberg, N.; Suchiman, H.E.D.; Groot, C.P.G.M. de; Reinders, M.J.T. & Slagboom, P.E. (2024), Secondary integrated analysis of multi-tissue transcriptomic responses to a combined lifestyle intervention in older adults from the GOTO nonrandomized trial, Nature Communications 15(1).
- Andreu-Sanchez, S.; Ahmad, S.; Kurilshikov, A.; Beekman, M.; Ghanbari, M.; Faassen, M. van; Munckhof, I.C.L. van den; Steur, M.; Harms, A.; Hankemeier, T.; Ikram, M.A.; Kavousi, M.; Voortman, T.; Kraaij, R.; Netea, M.G.; Rutten, J.H.W.; Riksen, N.P.; Zhernakova, A.; Kuipers, F.; Slagboom, P.E.; Duijn, C.M. van; Fu, J.Y. & Vojinovic, D. (2024), Unraveling interindividual variation of trimethylamine N-oxide and its precursors at the population level, iMeta.
- Karjalainen, M.K.; Karthikeyan, S.; Oliver-Williams, C.; Sliz, E.; Allara, E.; Fung, W.T.; Surendran, P.; Zhang, W.H.; Jousilahti, P.; Kristiansson, K.; Salomaa, V.; Goodwin, M.; Hughes, D.A.; Boehnke, M.; Silva, L.F.; Yin, X.Y.; Mahajan, A.; Neville, M.J.; Zuydam, N.R. van; Mutsert, R. de; Li-Gao, R.; Mook-Kanamori, D.O.; Demirkan, A.; Liu, J.; Noordam, R.; Trompet, S.; Chen, Z.M.; Kartsonaki, C.; Li, L.M.; Lin, K.; Hagenbeek, F.A.; Hottenga, J.J.; Pool, R.; Ikram, M.A.; Meurs, J. van; Haller, T.; Milaneschi, Y.; Kähönen, M.; Mishra, P.P.; Joshi, P.K.; Macdonald-Dunlop, E.; Mangino, M.; Zierer, J.; Acar, I.E.; Hoyng, C.B.; Lechanteur, Y.T.E.; Franke, L.; Kurilshikov, A.; Zhernakova, A.; Beekman, M.; Akker, E.B. van den; Kolcic, I.; Polasek, O.; Rudan, I.; Gieger, C.; Waldenberger, M.; Asselbergs, F.W.; Hayward, C.; Fu, J.Y.; Hollander, A.I. den; Menni, C.; Spector, T.D.; Wilson, J.F.; Lehtimäki, T.; Raitakari, O.T.; Penninx, B.W.J.H.; Esko, T.; Walters, R.G.; Jukema, J.W.; Sattar, N.; Ghanbari, M.; Dijk, K.W. van; Karpe, F.; McCarthy, M.I.; Laakso, M.; Järvelin, M.R.; Timpson, N.J.; Perola, M.; Kooner, J.S.; Chambers, J.C.; Duijn, C. van; Slagboom, P.E.; Boomsma, D.I.; Danesh, J.; Ala-Korpela, M.; Butterworth, A.S.; Kettunen, J.; China Kadoorie Biobank; Estonian Biobank Res Team & FinnGen (2024), Genome-wide characterization of circulating metabolic biomarkers, Nature.
- Sluiskes, M.H.; Goeman, J.J.; Beekman, M.; Slagboom, P.E.; Putter, H. & Rodriguez-Girondo, M. (2024), Clarifying the biological and statistical assumptions of cross-sectional biological age predictors , BMC Medical Research Methodology 24(1).
- Yaqub, A.; Vojinovic, D.; Vernooij, M.W.; Slagboom, P.E.; Ghanbari, M.; Beekman, M.; Grond, J. van der; Hankemeier, T.; Duijn, C.M. van; Ikram, M.A. & Ahmad, S. (2024), Plasma trimethylamine N-oxide (TMAO), Alzheimer's Research and Therapy 16(1).
- Holstein, Y. van; Mooijaart, S.P.; Oevelen, M. van; Deudekom, F.J. van; Vojinovic, D.; Bizzarri, D.; Akker, E.B. van den; Noordam, R.; Deelen, J.; Heemst, D. van; Glas, N.A. de; Holterhues, C.; Labots, G.; Bos, F. van den; Beekman, M.; Slagboom, P.E.; Munster, B.C. van; Portielje, J.E.A. & Trompet, S. (2024), The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors, Geroscience.
- Kat, A.C. de; Roelofs, F.; Slagboom, P.E.; Broekmans, F.J.M.; Beekman, M. & Berg, N. van den (2024), Late reproduction is associated with extended female survival but not with familial longevity, Reproductive BioMedicine Online 49(3).
- Schoissengeier, V.; Maqboul, L.; Weber, D.; Grune, T.; Bürkle, A.; Moreno-Villaneuva, M.; Franceschi, C.; Capri, M.; Bernhard, J.; Toussaint, O.; Debacq-Chainiaux, F.; Weinberger, B.; Gonos, E.S.; Sikora, E.; Dollé, M.; Jansen, E.; Slagboom, P.E.; Hervonnen, A.; Hurme, M.; Breusing, N.; Frank, J.; Bulmer, A.C. & Wagner, K.H. (2024), Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort, iScience 27(7).
- Sluiskes, M.; Goeman, J.; Beekman, M.; Slagboom, E.; Akker, E. van den; Putter, H. & Rodríguez-Girondo, M. (2024), The AccelerAge framework, European Journal of Epidemiology.
- Sterenborg, R.B.T.M.; Steinbrenner, I.; Li, Y.; Bujnis, M.N.; Naito, T.; Marouli, E.; Galesloot, T.E.; Babajide, O.; Andreasen, L.; Astrup, A.; Asvold, B.O.; Bandinelli, S.; Beekman, M.; Beilby, J.P.; Bork-Jensen, J.; Boutin, T.; Brody, J.A.; Brown, S.J.; Brumpton, B.; Campbell, P.J.; Cappola, A.R.; Ceresini, G.; Chaker, L.; Chasman, D.; Concas, M.P.; Almeida, R.C. de; Cross, S.M.; Cucca, F.; Deary, I.J.; Kjaergaard, A.D.; Tcheugui, J.B.E.; Ellervik, C.; Eriksson, J.G.; Ferrucci, L.; Freudenberg, J.; Fuchsberger, C.; Gieger, C.; Giulianini, F.; Gögele, M.; Graham, S.E.; Grarup, N.; Gunjaca, I.; Hansen, T.; Harding, B.N.; Harris, S.E.; Haunso, S.; Hayward, C.; Hui, J.; Ittermann, T.; Jukema, J.W.; Kajantie, E.; Kanters, J.K.; Kårhus, L.L.; Kiemeney, L.A.L.M.; Kloppenburg, M.; Kühnel, B.; Lahti, J.; Langenberg, C.; Lapauw, B.; Leese, G.; Li, S.; Liewald, D.C.M.; Linneberg, A.; Lominchar, J.V.T.; Luan, J.A.; Martin, N.G.; Matana, A.; Meima, M.E.; Meitinger, T.; Meulenbelt, I.; Mitchell, B.D.; Mollehave, L.T.; Mora, S.; Naitza, S.; Nauck, M.; Netea-Maier, R.T.; Noordam, R.; Nursyifa, C.; Okada, Y.; Onano, S.; Papadopoulou, A.; Palmer, C.N.A.; Pattaro, C.; Pedersen, O.; Peters, A.; Pietzner, M.; Polasek, O.; Pramstaller, P.P.; Psaty, B.M.; Punda, A.; Ray, D.; Redmond, P.; Richards, J.B.; Ridker, P.M.; Russ, T.C.; Ryan, K.A.; Olesen, M.S.; Schultheiss, U.T.; Selvin, E.; Siddiqui, M.K.; Sidore, C.; Slagboom, P.E.; Sorensen, T.I.A.; Soto-Pedre, E.; Spector, T.D.; Spedicati, B.; Srinivasan, S.; Starr, J.M.; Stott, D.J.; Tanaka, T.; Torlak, V.; Trompet, S.; Tuhkanen, J.; Uitterlinden, A.G.; Akker, E.B. van den; Eynde, T. van den; Klauw, M.M. van der; Heemst, D. van; Verroken, C.; Visser, W.E.; Vojinovic, D.; Völzke, H.; Waldenberger, M.; Walsh, J.P.; Wareham, N.J.; Weiss, S.; Willer, C.J.; Wilson, S.G.; Wolffenbuttel, B.H.R.; Wouters, H.J.C.M.; Wright, M.J.; Yang, Q.; Zemunik, T.; Zhou, W.; Zhu, G.; Zöllner, S.; Smit, J.W.A.; Peeters, R.P.; Köttgen, A.; Teumer, A.; Medici, M.; Ghs DiscovEHR & Regeneron Genetics Ctr (2024), Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications, Nature Communications 15(1).
- Morwani-Mangnani, J.; Rodriguez-Girondo, M.; Singh-Povel, C.; Verlaan, S.; Beekman, M. & Slagboom, P.E. (2024), Physical activity and fiber intake beneficial for muscle mass and strength preservation during aging, Experimental Gerontology 193.
- Beran, M.; Jansen, W.J.; Oomens, J.E.; Moonen, J.E.F.; Slagboom, P.E.; Huisman, M.; Kok, A.A.L.; Nooyens, A.C.J.; Verschuren, W.M.M.; Stehouwer, C.D.A.; Schalkwijk, C.; Köhler, S.; Beekman, M.; Slagboom, P.E.; Wolters, F.J.; Ikram, M.A.; Vallerga, C.L.; Meurs, J.B.J. van; Ghanbari, M.; Vonk, J.M.J.; Geerlings, M.I.; Sloten, T.T. van; Schram, M.T. & NCDC Consortium (2024), Biomarkers of endothelial dysfunction and cognition, Alzheimer's & Dementia: The Journal of the Alzheimer's Association.
- Weihs, A.; Chaker, L.; Martin, T.C.; Braun, K.V.E.; Campbell, P.J.; Cox, S.R.; Fornage, M.; Gieger, C.; Grabe, H.J.; Grallert, H.; Harris, S.E.; Kuhnel, B.; Marioni, R.E.; Martin, N.G.; McCartney, D.L.; McRae, A.F.; Meisinger, C.; Meurs, J.B.J. van; Nano, J.; Nauck, M.; Peters, A.; Prokisch, H.; Roden, M.; Selvin, E.; Beekman, M.; Heemst, D. van; Slagboom, E.P.; Swenson, B.R.; Tin, A.; Tsai, P.C.; Uitterlinden, A.; Visser, W.E.; Volzke, H.; Waldenberger, M.; Walsh, J.P.; Kottgen, A.; Wilson, S.G.; Peeters, R.P.; Bell, J.T.; Medici, M. & Teumer, A. (2023), Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9, Thyroid 33(3): 301-311.
- Groene, S.G.; Gremmen, I.J.; Zwet, E.W. van; Roest, A.A.W.; Haak, M.C.; Klink, J.M.M. van; Lopriore, E.; Heijmans, B.T. & Bruin, C. de (2023), Fetal growth restriction inhibits childhood growth despite catch-up in discordant identical twins, European journal of endocrinology 189(2): 183-189.
- Walton, E.; Baltramonaityte, V.; Calhoun, V.; Heijmans, B.T.; Thompson, P.M. & Cecil, C.A.M. (2023), A systematic review of neuroimaging epigenetic research: calling for an increased focus on development, Molecular Psychiatry 28(7): 2839-2847.
- Kochlik, B.; Herpich, C.; Moreno-Villanueva, M.; Klaus, S.; Müller-Werdan, U.; Weinberger, B.; Fiegl, S.; Toussaint, O.; Debacq-Chainiaux, F.; Schön, C.; Bernhard, J.; Breusing, N.; Gonos, E.S.; Franceschi, C.; Capri, M.; Sikora, E.; Hervonen, A.; Hurme, M.; Slagboom, P.E.; Dolle, M.E.T.; Jansen, E.; Grune, T.; Bürkle, A. & Norman, K. (2023), Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study, Geroscience.
- Kuiper, L.M.; Polinder-Bos, H.A.; Bizzarri, D.; Vojinovic, D.; Vallerga, C.L.; Beekman, M.; Dollé, E.T.; Ghanbari, M.; Voortman, T.; Reinders, M.J.T.; Verschuren, W.M.M.; Slagboom, P.E.; Akker, E.B. van den & Meurs, J.B.J. van (2023), Epigenetic and metabolomic biomarkers for biological age, The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences 78(10): 1753-1762.
- Costeira, R.; Ruiz, L.D.; Sinke, L.; Christiansen, C.; Heijmans, B.; Slagboom, E.; Waldenberger, M.; Berry, S.; Ordovás, J.M. & Bell, J.T. (2023), Human DNA methylation trajectories of the postprandial metabolic response to food, Annals of Nutrition and Metabolism 79: 353-353.
- Boone, I.; Tuerlings, M.; Almeida, R.C. de; Lehmann, J.; Ramos, Y.; Nelissen, R.; Slagboom, E.; Keizer, P. de & Meulenbelt, I. (2023), Identified senescence endotypes in aged cartilage are reflected in the blood metabolome, Geroscience 46.
- Berg, N. van den; Rodríguez-Girondo, M.; Dijk, I.K. van; Slagboom, P.E. & Beekman, M. (2023), Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles, Nature Communications 14(1).
- Costeira, R.; Evangelista, L.; Wilson, R.; Yan, X.Y.; Hellbach, F.; Sinke, L.; Christiansen, C.; Villicana, S.; Masachs, O.M.; Tsai, P.C.; Mangino, M.; Menni, C.; Berry, S.E.; Beekman, M.; Heemst, D. van; Slagboom, P.E.; Heijmans, B.T.; Suhre, K.; Kastenmueller, G.; Gieger, C.; Peters, A.; Small, K.S.; Linseisen, J.; Waldenberger, M. & Bell, J.T. (2023), Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome, Clinical Epigenetics 15(1).
- Bizzarri, D.; Reinders, M.J.T.; Beekman, M.; Slagboom, P.E.; Akker, E.B. van den & BbmriNl (2023), Technical report, Metabolites 13(12).
- Dekkers, K.F.; Slieker, R.C.; Ioan-Facsinay, A.; Iterson, M. van; Ikram, M.A.; Greevenbroek, M.M.J. van; Veldink, J.H.; Franke, L.; Boomsma, D.I.; Slagboom, P.E.; Jukema, J.W.; Heijmans, B.T. & BIOS consortium (2023), Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response, Nature Communications 14(1).
- Kavousi, M.; Bos, M.M.; Barnes, H.J.; Cardenas, C.L.L.; Wong, D.R.; Lu, H.J.; Hodonsky, C.J.; Landsmeer, L.P.L.; Turner, A.W.; Kho, M.; Hasbani, N.R.; Vries, P.S. de; Bowden, D.W.; Chopade, S.; Deelen, J.; Benavente, E.D.; Guo, X.Q.; Hofer, E.; Hwang, S.J.; Lutz, S.M.; Lyytikaeinen, L.P.; Slenders, L.; Smith, A.V.; Stanislawski, M.A.; Setten, J. van; Wong, Q.N.; Yanek, L.R.; Becker, D.M.; Beekman, M.; Budoff, M.J.; Feitosa, M.F.; Finan, C.; Hilliard, A.T.; Kardia, S.L.R.; Kovacic, J.C.; Kral, B.G.; Langefeld, C.D.; Launer, L.J.; Malik, S.; Hoesein, F.A.A.M.; Mokry, M.; Schmidt, R.; Smith, J.A.; Taylor, K.D.; Terry, J.G.; Grond, J. van der; Meurs, J. van; Vliegenthart, R.; Xu, J.Z.; Young, K.A.; Zilhao, N.R.; Zweiker, R.; Assimes, T.L.; Becker, L.C.; Bos, D.; Carr, J.J.; Cupples, L.A.; Kleijn, D.P.V. de; Winther, M. de; Ruijter, H.M. den; Fornage, M.; Freedman, B.I.; Gudnason, V.; Hingorani, A.D.; Hokanson, J.E.; Ikram, M.A.; Isgum, I.; Jacobs, D.R.; Kaehoenen, M.; Lange, L.A.; Lehtimaeki, T.; Pasterkamp, G.; Raitakari, O.T.; Schmidt, H.; Slagboom, P.E.; Uitterlinden, A.G.; Vernooij, M.W.; Bis, J.C.; Franceschini, N.; Psaty, B.M.; Post, W.S.; Rotter, J.I.; Bjoerkegren, J.L.M.; O'Donnell, C.J.; Bielak, L.F.; Peyser, P.A.; Malhotra, R.; Laan, S.W. van der & Miller, C.L. (2023), Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification, Nature Genetics 55.
- Giacconi, R.; Piacenza, F.; Aversano, V.; Zampieri, M.; Bürkle, A.; Villanueva, M.M.; Dollé, M.E.T.; Jansen, E.; Grune, T.; Gonos, E.S.; Franceschi, C.; Capri, M.; Weinberger, B.; Sikora, E.; Toussaint, O.; Debacq-Chainiaux, F.; Stuetz, W.; Slagboom, P.E.; Bernhardt, J.; Fernández-Sánchez, M.L.; Provinciali, M. & Malavolta, M. (2023), Uncovering the relationship between selenium status, age, health, and dietary habits, Nutrients 15(9).
- Todtenhaupt, P.; Franken, L.A.; Groene, S.G.; Hoolwerff, M. van; Meeren, L.E. van der; Klink, J.M.M. van; Roest, A.A.W.; Bruin, C. de; Ramos, Y.F.M.; Haak, M.C.; Lopriore, E.; Heijmans, B.T. & Pel, M. van (2023), A robust and standardized method to isolate and expand mesenchymal stromal cells from human umbilical cord, Cytotherapy 25(10): 1057-1068.
- Bizzarri, D.; Reinders, M.J.T.; Beekman, M.; Slagboom, P.E.; Akker, E.B. van den & BbmriNl (2023), Technical report, Metabolites 13(12).
- Schorr, K.; Agayn, V.; Vries, J. de; Groot, L.C.P.G.M. de; Beekman, M. & Slagboom, P.E. (2023), An unhealthful plant-based diet and circulating hsCRP levels are independently associated with lower physical well-being in older adults, Proceedings of the Nutrition Society 82(OCE5).
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- Brandys, M.K.; Kas, M.J.H.; Elburg, A.A. van; Ophoff, R.; Slof-Op't Landt, M.C.T.; Middeldorp, C.M.; Boomsma, D.I.; Furth, E.F. van; Slagboom, P.E. & Adan, R.A.H. (2013), The Val66Met polymorphism of the BDNF gene in anorexia nervosa: New data and a meta-analysis.
- Sanchez-Faddeev, H.; Pijpe, J.; Hulle, T. van der; Meij, H.J.; Gaag, K.J. van der; Slagboom, P.E.; Westendorp, R.G.J. & Knijff, P. de (2013), The influence of clan structure on the genetic variation in a single Ghanaian village, European Journal of Human Genetics 21(10): 1134-1139.
- Gonzalez-Covarrubias, V.; Beekman, M.; Uh, H.W.; Dane, A.; Troost, J.; Paliukhovich, I.; Kloet, F.M. van der; Houwing-Duistermaat, J.; Vreeken, R.J.; Hankemeier, T. & Slagboom, E.P. (2013), Lipidomics of familial longevity, Aging Cell 12(3): 426-434.
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- Hart, L.M. 't; Fritsche, A.; Nijpels, G.; Leeuwen, N. van; Donnelly, L.A.; Dekker, J.M.; Alssema, M.; Fadista, J.; Carlotti, F.; Gjesing, A.P.; Palmer, C.N.A.; Haeften, T.W. van; Herzberg-Schafer, S.A.; Simonis-Bik, A.M.C.; Houwing-Duistermaat, J.J.; Helmer, Q.; Deelen, J.; Guigas, B.; Hansen, T.; Machicao, F.; Willemsen, G.; Heine, R.J.; Kramer, M.H.H.; Holst, J.J.; Koning, E.J.P. de; Haring, H.U.; Pedersen, O.; Groop, L.; Geus, E.J.C. de; Slagboom, P.E.; Boomsma, D.I.; Eekhoff, E.M.W.; Pearson, E.R. & Diamant, M. (2013), The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway, Diabetes 62(9): 3275-3281.
- Streppel, M.T.; Vries, J.H.M. de; Meijboom, S.; Beekman, M.; Craen, A.J.M. de; Slagboom, P.E. & Feskens, E.J.M. (2013), Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study, Nutrition Journal 12.
- Beenakker, K.G.M.; Westendorp, R.G.J.; Craen, A.J.M. de; Slagboom, P.E.; Heemst, D. van & Maier, A.B. (2013), Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength., Aging Cell 12(4): 682-9.
- Evangelou, E.; Valdes, A.M.; Castano-Betancourt, M.C.; Doherty, M.; Doherty, S.; Esko, T.; Ingvarsson, T.; Ioannidis, J.P.A.; Kloppenburg, M.; Metspalu, A.; Ntzani, E.E.; Panoutsopoulou, K.; Slagboom, P.E.; Southam, L.; Spector, T.D.; Styrkarsdottir, U.; Stefanson, K.; Uitterlinden, A.G.; Wheeler, M.; Zeggini, E.; Meulenbelt, I.; Meurs, J.B. van; ArcOGEN Consortium & TREAT-OA Consortium (2013), The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome- wide statistical significance in males, Annals of the Rheumatic Diseases 72(7): 1264-U202.
- Lotz, M.; Martel-Pelletier, J.; Christiansen, C.; Brandi, M.L.; Bruyere, O.; Chapurlat, R.; Collette, J.; Cooper, C.; Giacovelli, G.; Kanis, J.A.; Karsdal, M.A.; Kraus, V.; Lems, W.F.; Meulenbelt, I.; Pelletier, J.P.; Raynauld, J.P.; Reiter-Niesert, S.; Rizzoli, R.; Sandell, L.J.; Spil, W.E. van & Reginster, J.Y. (2013), Value of biomarkers in osteoarthritis: current status and perspectives, Annals of the Rheumatic Diseases 72(11): 1756-1763.
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- Slof-Op't Landt, M.C.T.; Bartels, M.; Middeldorp, C.M.; Beijsterveldt, C.E.M.; Slagboom, P.E.; Boomsma, D.I.; Furth, E.F. van & Meulenbelt, I. (2013), Genetic Variation at the TPH2 Gene Influences Impulsivity in Addition to Eating Disorders, Behavior Genetics 43(1): 24-33.
- Altmann-Schneider, I.; Grond, J. van der; Slagboom, P.E.; Westendorp, R.G.J.; Maier, A.B.; Buchem, M.A. van & Craen, A.J.M. de (2013), Lower susceptibility to cerebral small vessel disease in human familial longevity: the Leiden Longevity Study.
- Altmann-Schneider, I.; Grond, J. van der; Slagboom, P.E.; Westendorp, R.G.J.; Maier, A.B.; Buchem, M.A. van & Craen, A.J.M. de (2013), Lower Susceptibility to Cerebral Small Vessel Disease in Human Familial Longevity The Leiden Longevity Study, Stroke 44(1): 9-14.
- Verschuren, J.J.W.; Trompet, S.; Sampietro, M.L.; Heijmans, B.T.; Koch, W.; Kastrati, A.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Quax, P.H.A. & Jukema, J.W. (2013), Pathway Analysis Using Genome-Wide Association Study Data for Coronary Restenosis - A Potential Role for the PARVB Gene, PLoS ONE 8(8).
- Stijntjes, M.; Craen, A.J.M. de; Heemst, D. van; Meskers, C.G.M.; Buchem, M.A. van; Westendorp, R.G.J.; Slagboom, P.E. & Maier, A.B. (2013), Familial Longevity Is Marked by Better Cognitive Performance at Middle Age: The Leiden Longevity Study, PLoS ONE 8(3).
- Passtoors, W.M.; Beekman, M.; Deelen, J.; Breggen, R. van der; Maier, A.B.; Guigas, B.; Derhovanessian, E.; Heemst, D. van; Craen, A.J.M. de; Gunn, D.A.; Pawelec, G. & Slagboom, P.E. (2013), Gene expression analysis of mTOR pathway: association with human longevity, Aging Cell 12(1): 24-31.
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- Bomer, N.; Ramos, Y.F.; Bos, S.D.; Duijnisveld, B.J.; Slagboom, P.E.; Nelissen, R.G. & Meulenbelt, I. (2013), DIO2 FUNCTIONS VIA T3: AN IN VITRO MODEL FOR CHONDROGENESIS, Osteoarthritis and Cartilage 21: S280-S281.
- Kiezun, A.; Pulit, S.L.; Francioli, L.C.; Dijk, F. van; Swertz, M.; Boomsma, D.I.; Duijn, C.M. van; Slagboom, P.E.; Ommen, G.J.B. van; Wijmenga, C.; Bakker, P.I.W. de; Sunyaev, S.R. & Genome Netherlands Consortium (2013), Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency, PLoS Genetics 9(2).
- Thijssen, P.E.; Tobi, E.W.; Balog, J.; Schouten, S.G.; Kremer, D.; Bouazzaoui, F. el; Henneman, P.; Putter, H.; Slagboom, P.E.; Heijmans, B.T. & Maarel, S.M. van der (2013), Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence Commonalities and differences between chromosomes, Epigenetics 8(5): 512-521.
- Lauc, G.; Huffman, J.E.; Pucic, M.; Zgaga, L.; Adamczyk, B.; Muzinic, A.; Novokmet, M.; Polasek, O.; Gornik, O.; Kristic, J.; Keser, T.; Vitart, V.; Scheijen, B.; Uh, H.W.; Molokhia, M.; Patrick, A.L.; McKeigue, P.; Kolcic, I.; Lukic, I.K.; Swann, O.; Leeuwen, F.N. van; Ruhaak, L.R.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Beekman, M.; Craen, A.J.M. de; Deelder, A.M.; Zeng, Q.; Wang, W.; Hastie, N.D.; Gyllensten, U.; Wilson, J.F.; Wuhrer, M.; Wright, A.F.; Rudd, P.M.; Hayward, C.; Aulchenko, Y.; Campbell, H. & Rudan, I. (2013), Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers, PLoS Genetics 9(1): -.
- Peters, M.J.; Broer, L.; Willemen, H.L.D.M.; Eiriksdottir, G.; Hocking, L.J.; Holliday, K.L.; Horan, M.A.; Meulenbelt, I.; Neogi, T.; Popham, M.; Schmidt, C.O.; Soni, A.; Valdes, A.M.; Amin, N.; Dennison, E.M.; Eijkelkamp, N.; Harris, T.B.; Hart, D.J.; Hofman, A.; Huygen, F.J.P.M.; Jameson, K.A.; Jones, G.T.; Launer, L.J.; Kerkhof, H.J.M.; Kruijf, M. de; McBeth, J.; Kloppenburg, M.; Ollier, W.E.; Oostra, B.; Payton, A.; Rivadeneira, F.; Smith, B.H.; Smith, A.V.; Stolk, L.; Teumer, A.; Thomson, W.; Uitterlinden, A.G.; Wang, K.; Wingerden, S.H. van; Arden, N.K.; Cooper, C.; Felson, D.; Gudnason, V.; Macfarlane, G.J.; Pendleton, N.; Slagboom, P.E.; Spector, T.D.; Volzke, H.; Kavelaars, A.; Duijn, C.M. van; Williams, F.M.K. & Meurs, J.B.J. van (2013), Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region, Annals of the Rheumatic Diseases 72(3): 427-436.
- Bijsterbosch, J.; Kloppenburg, M.; Reijnierse, M.; Rosendaal, F.R.; Huizinga, T.W.J.; Slagboom, P.E. & Meulenbelt, I. (2013), Association study of candidate genes for the progression of hand osteoarthritis, Osteoarthritis and Cartilage 21(4): 565-569.
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- Verschuren, J.J.W.; Trompet, S.; Deelen, J.; Stott, D.J.; Sattar, N.; Buckley, B.M.; Ford, I.; Heijmans, B.T.; Guchelaar, H.J.; Houwing-Duistermaat, J.J.; Slagboom, P.E. & Jukema, J.W. (2013), Non-Homologous End-Joining Pathway Associated with Occurrence of Myocardial Infarction: Gene Set Analysis of Genome-Wide Association Study Data, PLoS ONE 8(2).
- Postmus, I.; Trompet, S.; Craen, A.J.M. de; Buckley, B.M.; Ford, I.; Stott, D.J.; Sattar, N.; Slagboom, P.E.; Westendorp, R.G.J. & Jukema, J.W. (2013), PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population., Journal of Lipid Research 54(2): 561-6.
- Gunn, D.A.; Craen, A.J.M. de; Dick, J.L.; Tomlin, C.C.; Heemst, D. van; Catt, S.D.; Griffiths, T.; Ogden, S.; Maier, A.B.; Murray, P.G.; Griffiths, C.E.M.; Slagboom, P.E. & Westendorp, R.G.J. (2013), Facial Appearance Reflects Human Familial Longevity and Cardiovascular Disease Risk in Healthy Individuals, Journals of Gerontology, Series A 68(2): 145-152.
- Noordam, R.; Gunn, D.A.; Tomlin, C.C.; Maier, A.B.; Griffiths, T.; Catt, S.D.; Ogden, S.; Slagboom, P.E.; Westendorp, R.G.J.; Griffiths, C.E.M.; Heemst, D. van; Craen, A.J.M. de & Leiden Longevity Study Grp (2013), Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study.
- Willemsen, G.; Vink, J.M.; Abdellaoui, A.; Braber, A. den; Beek, J.H.D.A. van; Draisma, H.H.M.; Dongen, J. van; van't Ent, D.; Geels, L.M.; Lien, R. van; Ligthart, L.; Kattenberg, M.; Mbarek, H.; Moor, M.H.M. de; Neijts, M.; Pool, R.; Stroo, N.; Kluft, C.; Suchiman, H.E.D.; Slagboom, P.E.; Geus, E.J.C. de & Boomsma, D.I. (2013), The Adult Netherlands Twin Register: Twenty-Five Years of Survey and Biological Data Collection, Twin Research and Human Genetics 16(1): 271-281.
- Dall'Olio, F.; Vanhooren, V.; Chen, C.C.; Slagboom, P.E.; Wuhrer, M. & Franceschi, C. (2013), N-glycomic biomarkers of biological aging and longevity: A link with inflammaging, Ageing Research Reviews 12(2): 685-698.
- Deelen, J.; Beekman, M.; Capri, M.; Franceschi, C. & Slagboom, P.E. (2013), Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges, BioEssays 35(4): 386-396.
- Passtoors, W.M.; Beekman, M.; Deelen, J.; Breggen, R. van der; Maier, A.B.; Guigas, B.; Derhovanessian, E.; Heemst, D. van; Craen, A.J.M. de; Gunn, D.A.; Pawelec, G. & Slagboom, P.E. (2013), Gene expression analysis of mTOR pathway: association with human longevity., Aging Cell 12(1): 24-31.
- Zhang, Y.J.; Lameijer, E.W.; Hoen, P.A.C. 't; Ning, Z.M.; Slagboom, P.E. & Ye, K. (2012), PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data, Bioinformatics 28(4).
- Sampietro, M.L.; Pons, D.; Knijff, P. de; Slagboom, P.E.; Zwinderman, A.H. & Jukema, J.W. (2012), A genome wide association analysis in the GENDER study, Netherlands Heart Journal 20: 56-58.
- Talens, R.P.; Jukema, J.W.; Trompet, S.; Kremer, D.; Westendorp, R.G.J.; Lumey, L.H.; Sattar, N.; Putter, H.; Slagboom, P.E.; Heijmans, B.T. & PROSPER Grp (2012), Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction, International Journal of Epidemiology 41(1): 106-115.
- Noordam, R.; Gunn, D.A.; Tomlin, C.C.; Rozing, M.P.; Maier, A.B.; Slagboom, P.E.; Westendorp, R.G.J.; Heemst, D. van; Craen, A.J.M. de & Leiden Longevity Study Grp (2012), Cortisol serum levels in familial longevity and perceived age: The Leiden Longevity Study, Psychoneuroendocrinology 37(10): 1669-1675.
- Huffman, D.M.; Deelen, J.; Ye, K.; Bergman, A.; Slagboom, E.P.; Barzilai, N. & Atzmon, G. (2012), Distinguishing Between Longevity and Buffered-Deleterious Genotypes for Exceptional Human Longevity: The Case of the MTP Gene, Journals of Gerontology, Series A 67(11): 1153-1160.
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- Hogervorst, T.; Eilander, W.; Fikkers, J.T. & Meulenbelt, I. (2012), Hip Ontogenesis: How Evolution, Genes, and Load History Shape Hip Morphotype and Cartilotype, Clinical Orthopaedics and Related Research 470(12): 3284-3296.
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- Passtoors, W.M.; Boer, J.M.; Goeman, J.J.; Akker, E.B. van den; Deelen, J.; Zwaan, B.J.; Scarborough, A.; Breggen, R. van der; Vossen, R.H.A.M.; Houwing-Duistermaat, J.J.; Ommen, G.J.B. van; Westendorp, R.G.J.; Heemst, D. van; Craen, A.J.M. de; White, A.J.; Gunn, D.A.; Beekman, M. & Slagboom, P.E. (2012), Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R, PLoS ONE 7(1): -.
- Obermann-Borst, S.A.; Slagboom, P.E.; Eilers, P.H.C.; Tobi, E.W.; Jong, F.H. de; Steegers, E.A.P.; Heijmans, B.T. & Steegers-Theunissen, R.P.M. (2011), Duration of Breastfeeding Is Associated with the Methylation of LEP in Young Children, Journal of Developmental Origins of Health and Disease 2: S118-S119.
- Waarsing, J.H.; Kloppenburg, M.; Slagboom, P.E.; Kroon, H.M.; Houwing-Duistermaat, J.J.; Weinans, H. & Meulenbelt, I. (2011), Osteoarthritis Susceptibility Genes Influence the Association Between Hip Morphology and Osteoarthritis, Arthritis and Rheumatism 63(5): 1349-1354.
- Yusuf, E.; Ioan-Facsinay, A.; Bijsterbosch, J.; Klein-Wieringa, I.; Kwekkeboom, J.; Slagboom, P.E.; Huizinga, T.W.J. & Kloppenburg, M. (2011), Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis, Annals of the Rheumatic Diseases 70(7): 1282-1284.
- Yusuf, E.; Bijsterbosch, J.; Slagboom, P.E.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2011), Body mass index and alignment and their interaction as risk factors for progression of knees with radiographic signs of osteoarthritis, Osteoarthritis and Cartilage 19(9): 1117-1122.
- Panoutsopoulou, K.; Southam, L.; Elliott, K.S.; Wrayner, N.; Zhai, G.; Beazley, C.; Thorleifsson, G.; Arden, N.K.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Ollier, W.E.R.; Ralston, S.H.; Spector, T.D.; Valdes, A.M.; Wallis, G.A.; Wilkinson, J.M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F.J.; Bumpstead, S.; Cupples, L.A.; Day-Williams, A.G.; Dixon, K.; Doherty, S.A.; Esko, T.; Evangelou, E.; Felson, D.; Gomez-Reino, J.J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Halldorsson, B.V.; Hauksson, V.B.; Hofman, A.; Hunt, S.E.; Ioannidis, J.P.A.; Ingvarsson, T.; Jonsdottir, I.; Jonsson, H.; Keen, R.; Kerkhof, H.J.M.; Kloppenburg, M.G.; Koller, N.; Lakenberg, N.; Lane, N.E.; Lee, A.T.; Metspalu, A.; Meulenbelt, I.; Nevitt, M.C.; O'Neill, F.; Parimi, N.; Potter, S.C.; Rego-Perez, I.; Riancho, J.A.; Sherburn, K.; Slagboom, P.E.; Stefansson, K.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Thorsteinsdottir, U.; Tsezou, A.; Uitterlinden, A.G.; Meurs, J.B.J. van; Watkins, B.; Wheeler, M.; Mitchell, S.; Zhu, Y.; Zmuda, J.M.; Zeggini, E.; Loughlin, J. & arcOGEN Consortium (2011), Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study, Annals of the Rheumatic Diseases 70(5): 864-867.
- Kerkhof, H.J.M.; Doherty, M.; Arden, N.K.; Abramson, S.B.; Attur, M.; Bos, S.D.; Cooper, C.; Dennison, E.M.; Doherty, S.A.; Evangelou, E.; Hart, D.J.; Hofman, A.; Javaid, K.; Kerna, I.; Kisand, K.; Kloppenburg, M.; Krasnokutsky, S.; Maciewicz, R.A.; Meulenbelt, I.; Muir, K.R.; Rivadeneira, F.; Samuels, J.; Sezgin, M.; Slagboom, E.; Smith, A.J.P.; Spector, T.D.; Tamm, A.; Tamm, A.; Uitterlinden, A.G.; Wheeler, M.; Zhai, G.; Zhang, W.; Meurs, J.B.J. van & Valdes, A.M. (2011), Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis, Osteoarthritis and Cartilage 19(3): 265-271.
- Evangelou, E.; Valdes, A.M.; Kerkhof, H.J.M.; Styrkarsdottir, U.; Zhu, Y.Y.; Meulenbelt, I.; Lories, R.J.; Karassa, F.B.; Tylzanowski, P.; Bos, S.D.; Akune, T.; Arden, N.K.; Carr, A.; Chapman, K.; Cupples, L.A.; Dai, J.; Deloukas, P.; Doherty, M.; Doherty, S.; Engstrom, G.; Gonzalez, A.; Halldorsson, B.V.; Hammond, C.L.; Hart, D.J.; Helgadottir, H.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Kaprio, J.; Kawaguchi, H.; Kisand, K.; Kloppenburg, M.; Kujala, U.M.; Lohmander, L.S.; Loughlin, J.; Luyten, F.P.; Mabuchi, A.; McCaskie, A.; Nakajima, M.; Nilsson, P.M.; Nishida, N.; Ollier, W.E.R.; Panoutsopoulou, K.; Putte, T. van de; Ralston, S.H.; Rivadeneira, F.; Saarela, J.; Schulte-Merker, S.; Shi, D.Q.; Slagboom, P.E.; Sudo, A.; Tamm, A.; Tamm, A.; Thorleifsson, G.; Thorsteinsdottir, U.; Tsezou, A.; Wallis, G.A.; Wilkinson, J.M.; Yoshimura, N.; Zeggini, E.; Zhai, G.J.; Zhang, F.; Jonsdottir, I.; Uitterlinden, A.G.; Felson, D.T.; Meurs, J.B. van; Stefansson, K.; Ioannidis, J.P.A.; Spector, T.D.; ArcOGEN Consortium & Translation Res Europe Appl (2011), Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22, Annals of the Rheumatic Diseases 70(2): 349-355.
- Kerkhof, H.J.M.; Meulenbelt, I.; Akune, T.; Arden, N.K.; Aromaa, A.; Bierma-Zeinstra, S.M.A.; Carr, A.; Cooper, C.; Dai, J.; Doherty, M.; Doherty, S.A.; Felson, D.; Gonzalez, A.; Gordon, A.; Harilainen, A.; Hart, D.J.; Hauksson, V.B.; Heliovaara, M.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Jonsdottir, I.; Kawaguchi, H.; Kloppenburg, M.; Kujala, U.M.; Lane, N.E.; Leino-Arjas, P.; Lohmander, L.S.; Luyten, F.P.; Malizos, K.N.; Nakajima, M.; Nevitt, M.C.; Pols, H.A.P.; Rivadeneira, F.; Shi, D.; Slagboom, E.; Spector, T.D.; Stefansson, K.; Sudo, A.; Tamm, A.; Tamm, A.E.; Tsezou, A.; Uchida, A.; Uitterlinden, A.G.; Wilkinson, J.M.; Yoshimura, N.; Valdes, A.M. & Meurs, J.B.J. van (2011), Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium, Osteoarthritis and Cartilage 19(3): 254-264.
- Wijsman, C.A.; Heemst, D. van; Rozing, M.P.; Slagboom, P.E.; Beekman, M.; Craen, A.J.M. de; Maier, A.B.; Westendorp, R.G.J.; Blom, H.J. & Mooijaart, S.P. (2011), Homocysteine and Familial Longevity: The Leiden Longevity Study, PLoS ONE 6(3).
- Geus, E. de; Snieder, H.; Kupper, N.; Suchiman, E.; Slagboom, E.; Bartels, M.; Willemsen, G. & Boomsma, D. (2011), Heritability of cardiac sympathetic control at rest and during stress and the contribution of the Gln27Glu beta-2-adrenergic receptor polymorphism, Behavior Genetics 41(6): 899-899.
- Beijsterveldt, C.E.M. van; Middeldorp, C.M.; Landt, M.C.T.S.O.; Bartels, M.; Hottenga, J.J.; Suchiman, H.E.D.; Slagboom, P.E. & Boomsma, D.I. (2011), Influence of Candidate Genes on Attention Problems in Children: A Longitudinal Study, Behavior Genetics 41(1): 155-164.
- Pons, D.; Trompet, S.; Craen, A.J.M. de; Thijssen, P.E.; Quax, P.H.A.; Vries, M.R. de; Wierda, R.J.; Elsen, P.J. van den; Monraats, P.S.; Ewing, M.M.; Heijmans, B.T.; Slagboom, P.E.; Zwinderman, A.H.; Doevendans, P.A.F.M.; Tio, R.A.; Winter, R.J. de; Maat, M.P.M. de; Iakoubova, O.A.; Sattar, N.; Shepherd, J.; Westendorp, R.G.J.; Jukema, J.W.; PROSPER Study Grp; WOSCOPS Study Grp & GENDER Study Grp (2011), Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies, Heart 97(2): 143-150.
- Slagboom, P.E.; Beekman, M.; Passtoors, W.M.; Deelen, J.; Vaarhorst, A.A.M.; Boer, J.M.; Akker, E.B. van den; Heemst, D. van; Craen, A.J.M. de; Maier, A.B.; Rozing, M.; Mooijaart, S.P.; Heijmans, B.T. & Westendorp, R.G.J. (2011), Genomics of human longevity, Philosophical Transactions B: Biological Sciences 366(1561): 35-42.
- Meulenbelt, I.; Bos, S.D.; Chapman, K.; Breggen, R. van der; Houwing-Duistermaat, J.J.; Kremer, D.; Kloppenburg, M.; Carr, A.; Tsezou, A.; Gonzalez, A.; Loughlin, J. & Slagboom, E. (2011), Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility, Annals of the Rheumatic Diseases 70(1): 164-167.
- Rozing, M.P.; Mooijaart, S.P.; Beekman, M.; Wijsman, C.A.; Maier, A.B.; Bartke, A.; Westendorp, R.G.J.; Slagboom, E.P. & Heemst, D. van (2011), C-reactive protein and glucose regulation in familial longevity., AGE.
- Tobi, E.W.; Heijmans, B.T.; Kremer, D.; Putter, H.; Delemarre-van de Waal, H.A.; Finken, M.J.J.; Wit, J.M. & Slagboom, P.E. (2011), DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age., Epigenetics 6(2).
- Smith, N.L.; Huffman, J.E.; Strachan, D.P.; Huang, J.; Dehghan, A.; Trompet, S.; Lopez, L.M.; Shin, S.Y.; Baumert, J.; Vitart, V.; Bis, J.C.; Wild, S.H.; Rumley, A.; Yang, Q.; Uitterlinden, A.G.; Stott, D.J.; Davies, G.; Carter, A.M.; Thorand, B.; Polasek, O.; McKnight, B.; Campbell, H.; Rudnicka, A.R.; Chen, M.H.; Buckley, B.M.; Harris, S.E.; Peters, A.; Pulanic, D.; Lumley, T.; Craen, A.J.M. de; Liewald, D.C.; Gieger, C.; Campbell, S.; Ford, I.; Gow, A.J.; Luciano, M.; Porteous, D.J.; Guo, X.Q.; Sattar, N.; Tenesa, A.; Cushman, M.; Slagboom, P.E.; Visscher, P.M.; Spector, T.D.; Illig, T.; Rudan, I.; Bovill, E.G.; Wright, A.F.; McArdle, W.L.; Tofler, G.; Hofman, A.; Westendorp, R.G.J.; Starr, J.M.; Grant, P.J.; Karakas, M.; Hastie, N.D.; Psaty, B.M.; Wilson, J.F.; Lowe, G.D.O.; O'Donnell, C.J.; Witteman, J.C.M.; Jukema, J.W.; Deary, I.J.; Soranzo, N.; Koenig, W. & Hayward, C. (2011), Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults, Circulation 123(17): 1864+.
- Deelen, J.; Beekman, M.; Uh, H.W.; Helmer, Q.; Kuningas, M.; Christiansen, L.; Kremer, D.; Breggen, R. van der; Suchiman, H.E.D.; Lakenberg, N.; Akker, E.B. van den; Passtoors, W.M.; Tiemeier, H.; Heemst, D. van; Craen, A.J. de; Rivadeneira, F.; Geus, E.J. de; Perola, M.; Ouderaa, F.J. van der; Gunn, D.A.; Boomsma, D.I.; Uitterlinden, A.G.; Christensen, K.; Duijn, C.M. van; Heijmans, B.T.; Houwing-Duistermaat, J.J.; Westendorp, R.G.J. & Slagboom, P.E. (2011), Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited, Aging Cell 10(4): 686-698.
- Ling, C.H.Y.; Craen, A.J.M. de; Slagboom, P.E.; Gunn, D.A.; Stokkel, M.P.M.; Westendorp, R.G.J. & Maier, A.B. (2011), Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population., Clinical Nutrition 30(5): 610-5.
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- Noordam, R.; Gunn, D.A.; Tomlin, C.C.; Maier, A.B.; Mooijaart, S.P.; Slagboom, P.E.; Westendorp, R.G.J.; Craen, A.J.M. de; Heemst, D. van & Leiden Longevity Study Grp (2011), High serum glucose levels are associated with a higher perceived age., AGE.
- Trompet, S.; Craen, A.J.M. de; Postmus, I.; Ford, I.; Sattar, N.; Caslake, M.; Stott, D.J.; Buckley, B.M.; Sacks, F.; Devlin, J.J.; Slagboom, P.E.; Westendorp, R.G.J.; Jukema, J.W. & PROSPER Study Grp (2011), Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses., BMC Medical Genetics 12: 131.
- Trompet, S.; Pons, D.; Kanse, S.M.; Craen, A.J. de; Ikram, M.A.; Verschuren, J.J.; Zwinderman, A.H.; Doevendans, P.A.; Tio, R.A.; Winter, R.J. de; Slagboom, P.E.; Westendorp, R.G. & Jukema, J.W. (2011), Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality., Stroke Research and Treatment 2011: 424759.
- Ling, C.H.Y.; Craen, A.J.M. de; Slagboom, P.E.; Westendorp, R.G.J. & Maier, A.B. (2011), Handgrip strength at midlife and familial longevity : The Leiden Longevity Study., AGE.
- Waaijer, M.E.C.; Gunn, D.A.; Catt, S.D.; Ginkel, M. van; Craen, A.J.M. de; Hudson, N.M.; Heemst, D. van; Slagboom, P.E.; Westendorp, R.G.J. & Maier, A.B. (2011), Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study., AGE.
- Rius-Ottenheim, N.; Kromhout, D.; Craen, A.J.M. de; Geleijnse, J.M.; Mast, R.C. van der; Zitman, F.G.; Westendorp, R.G.; Slagboom, P.E. & Giltay, E.J. (2011), Parental longevity correlates with offspring's optimism in two cohorts of community-dwelling older subjects., AGE.
- Dekker, P.; Baalen, L.M. van; Dirks, R.W.; Slagboom, P.E.; Heemst, D. van; Tanke, H.J.; Westendorp, R.G.J. & Maier, A.B. (2011), Chronic Inhibition of the Respiratory Chain in Human Fibroblast Cultures: Differential Responses Related to Subject Chronological and Biological Age., Journals of Gerontology, Series A.
- Slagboom, P.E.; Beekman, M.; Passtoors, W.M.; Deelen, J.; Vaarhorst, A.A.M.; Boer, J.M.; Akker, E.B. van den; Heemst, D. van; Craen, A.J.M. de; Maier, A.B.; Rozing, M.; Mooijaart, S.P.; Heijmans, B.T. & Westendorp, R.G.J. (2011), Genomics of human longevity., Philosophical Transactions B: Biological Sciences 366(1561): 35-42.
- Sampietro, M.L.; Trompet, S.; Verschuren, J.J.W.; Talens, R.P.; Deelen, J.; Heijmans, B.T.; Winter, R.J. de; Tio, R.A.; Doevendans, P.A.F.M.; Ganesh, S.K.; Nabel, E.G.; Westra, H.J.; Franke, L.; Akker, E.B. van den; Westendorp, R.G.J.; Zwinderman, A.H.; Kastrati, A.; Koch, W.; Slagboom, P.E.; Knijff, P. de & Jukema, J.W. (2011), A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention., Human Molecular Genetics 20(23): 4748-57.
- Derhovanessian, E.; Maier, A.B.; Hahnel, K.; Beck, R.; Craen, A.J.M. de; Slagboom, E.P.; Westendorp, R.G.J. & Pawelec, G. (2011), Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4(+) and CD8(+) T-cells in humans.
- Martella, F.; Vermunt, J.K.; Beekman, M.; Westendorp, R.G.J.; Slagboom, P.E. & Houwing-Duistermaat, J.J. (2011), A mixture model with random-effects components for classifying sibling pairs, Statistics in Medicine 30(27): 3252-3264.
- Yusuf, E.; Bijsterbosch, J.; Slagboom, P.E.; Kroon, H.M.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2011), Association between Several Clinical and Radiological Determinants with Long-Term Clinical Progression and Good Prognosis of Lower Limb Osteoarthritis, PLoS ONE 6(10): -.
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- van den Akker EB, Verbruggen B, Heijmans BT, Beekman M, Kok JN, Slagboom PE & Reinders MJ (2011), Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis., Journal of Integrative Bioinformatics 8(2): 188.
- Landt, M.C.T.S.O. 't; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C.M.; Houwing-Duistermaat, J.J.; Trier, J. van; Onkenhout, E.J.; Vink, J.M.; Beijsterveldt, C.E.M. van; Brandys, M.K.; Sanders, N.; Zipfel, S.; Herzog, W.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; Zwaan, M. de; Herpertz, S.; Ehrlich, S.; Elburg, A.A. van; Adan, R.A.H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D.I.; Furth, E.F. van & Slagboom, P.E. (2011), Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting, Genes, Brain and Behavior 10(2): 236-243.
- Finken, M.J.J.; Meulenbelt, I.; Dekker, F.W.; Frolich, M.; Walther, F.J.; Romijn, J.A.; Slagboom, P.E.; Wit, J.M. & Dutch POPS-19 Collaborative Study (2011), Abdominal Fat Accumulation in Adults Born Preterm Exposed Antenatally to Maternal Glucocorticoid Treatment Is Dependent on Glucocorticoid Receptor Gene Variation, Journal of Clinical Endocrinology and Metabolism 96(10): E1650-E1655.
- Saviouk, V.; Hottenga, J.J.; Slagboom, E.P.; Distel, M.A.; Geus, E.J.C. de; Willemsen, G. & Boomsma, D.I. (2011), ADHD in Dutch Adults: Heritability and Linkage Study, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(3): 352-362.
- Yusuf, E.; Bijsterbosch, J.; Slagboom, P.E.; Kroon, H.M.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2011), Association between Several Clinical and Radiological Determinants with Long-Term Clinical Progression and Good Prognosis of Lower Limb Osteoarthritis., PLoS ONE 6(10): e25426.
- Skytthe, A.; Valensin, S.; Jeune, B.; Cevenini, E.; Balard, F.; Beekman, M.; Bezrukov, V.; Blanche, H.; Bolund, L.; Broczek, K.; Carru, C.; Christensen, K.; Christiansen, L.; Collerton, J.C.; Cotichini, R.; Craen, A.J.M. de; Dato, S.; Davies, K.; Benedictis, G. de; Deiana, L.; Flachsbart, F.; Gampe, J.; Gilbault, C.; Gonos, E.S.; Haimes, E.; Hervonen, A.; Hurme, M.A.; Janiszewska, D.; Jylha, M.; Kirkwood, T.B.L.; Kristensen, P.; Laiho, P.; Leon, A.; Marchisio, A.; Masciulli, R.; Nebel, A.; Passarino, G.; Pelicci, G.; Peltonen, L.; Perola, M.; Poulain, M.; Rea, I.M.; Remade, J.; Robine, J.M.; Schreiber, S.; Scurti, M.; Sevini, F.; Sikora, E.; Skouteri, A.; Slagboom, P.E.; Spazzafumo, L.; Stazi, M.A.; Toccaceli, V.; Toussaint, O.; Tornwall, O.; Vaupel, J.W.; Voutetakis, K.; Franceschi, C. & GEHA Consortium (2011), Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project, Experimental Gerontology 46(11): 934-945.
- Wijsman, C.A.; Rozing, M.P.; Streefland, T.C.M.; Cessie, S. le; Mooijaart, S.P.; Slagboom, P.E.; Westendorp, R.G.J.; Pijl, H.; Heemst, D. van & Leiden Longevity Study Grp (2011), Familial longevity is marked by enhanced insulin sensitivity., Aging Cell 10(1): 114-21.
- Talens, R.P.; Jukema, J.W.; Trompet, S.; Kremer, D.; Westendorp, R.G.J.; Lumey, L.H.; Sattar, N.; Putter, H.; Slagboom, P.E.; Heijmans, B.T. & PROSPER Grp (2011), Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction., International Journal of Epidemiology.
- Obermann-Borst, S.A.; Heijmans, B.T.; Slagboom, E.P.; Eilers, P.H.C.; Wildhagen, M.F.; Steegers, E.A.P. & Steegers-Theunissen, R.P.M. (2010), Periconception Maternal Risk Factors Affect DNA Methylation Profiles in Very Young Children, with Gender Effects., Reproductive Sciences 17(3): 223A-223A.
- Reiling, E.; Jafar-Mohammadi, B.; van't Riet, E.; Weedon, M.N.; Vliet-Ostaptchouk, J.V. van; Hansen, T.; Saxena, R.; Haeften, T.W. van; Arp, P.A.; , S. das; Nijpels, G.; Groenewoud, M.J.; Hove, E.C. van; Uitterlinden, A.G.; Smit, J.W.A.; Morris, A.D.; Doney, A.S.F.; Palmer, C.N.A.; Guiducci, C.; Hattersley, A.T.; Frayling, T.M.; Pedersen, O.; Slagboom, P.E.; Altshuler, D.M.; Groop, L.; Romijn, J.A.; Maassen, J.A.; Hofker, M.H.; Dekker, J.M.; McCarthy, M.I. & Hart, L.M. 't (2010), Genetic association analysis of LARS2 with type 2 diabetes, Diabetologia 53(1): 103-110.
- Meulenbelt, I.; Bos, S.D.; Kloppenburg, M.; Lakenberg, N.; Houwing-Duistermaat, J.J.; Watt, I.; Craen, A.J. de; Duijn, C.M. van & Slagboom, P.E. (2010), Interleukin-1 Gene Cluster Variants With Innate Cytokine Production Profiles and Osteoarthritis in Subjects From the Genetics, Osteoarthritis and Progression Study, Arthritis and Rheumatism 62(4): 1119-1126.
- Kuningas, M.; Bodegom, D. van; May, L.; Meij, J.J.; Slagboom, P.E. & Westendorp, R.G.J. (2010), Common CFTR gene variants influence body composition and survival in rural Ghana.
- Reiling, E.; Jafar-Mohammadi, B.; van't Riet, E.; Weedon, M.N.; Vliet-Ostaptchouk, J.V. van; Hansen, T.; Saxena, R.; Haeften, T.W. van; Arp, P.A.; , S. das; Nijpels, G.; Groenewoud, M.J.; Hove, E.C. van; Uitterlinden, A.G.; Smit, J.W.A.; Morris, A.D.; Doney, A.S.F.; Palmer, C.N.A.; Guiducci, C.; Hattersley, A.T.; Frayling, T.M.; Pedersen, O.; Slagboom, P.E.; Altshuler, D.M.; Groop, L.; Romijn, J.A.; Maassen, J.A.; Hofker, M.H.; Dekker, J.M.; McCarthy, M.I. & Hart, L.M. 't (2010), Genetic association analysis of LARS2 with type 2 diabetes., Diabetologia 53(1): 103-10.
- May, L.; Kuningas, M.; Bodegom, D. van; Meij, H.J.; Frolich, M.; Slagboom, P.E.; Mantovani, A. & Westendorp, R.G.J. (2010), Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women.
- Bijsterbosch, J.; Bemmel, J.M. van; Watt, I.; Meulenbelt, I.; Rosendaal, F.R.; Huizinga, T.W. & Kloppenburg, M. (2010), CARTILAGE LOSS AND PAIN ARE INDEPENDENT RISK FACTORS IN THE EVOLUTION OF EROSIVE HAND OSTEOARTHRITIS, Osteoarthritis and Cartilage 18: S126S126.
- Yusuf, E.; Bijsterbosch, J.; Slagboom, P.E.; Kroon, H.; Rosendaal, F.R.; Huizinga, T.W. & Kloppenburg, M. (2010), DETERMINANTS OF CLINICAL PROGRESSION OF LOWER EXTREMITY OSTEOARTHRITIS, Osteoarthritis and Cartilage 18: S159S159.
- Rozing, M.P.; Westendorp, R.G.J.; Craen, A.J.M. de; Frolich, M.; Goeij, M.C.M. de; Heijmans, B.T.; Beekman, M.; Wijsman, C.A.; Mooijaart, S.P.; Blauw, G.J.; Slagboom, P.E.; Heemst, D. van & Leiden Longevity Study Grp (2010), Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study, Journal of the American Geriatrics Society 58(3): 564-569.
- Landt, M.C.T.S.O.; Dolan, C.V.; Rebollo-Mesa, I.; Bartels, M.; Furth, E.F. van; Beijsterveldt, C.E.M. van; Meulenbelt, I.; Slagboom, P.E. & Boomsma, D.I. (2010), Sex differences in sum scores may be hard to interpret: The importance of measurement invariance. (vol 16, pg 415, 2010), Assessment 17(2): 278-278.
- Bos, S.D.; Lakenberg, N.; Breggen, R. van der; Houwing-Duistermaat, J.J.; Kloppenburg, M.; Craen, A.J.M. de; Beekman, M.; Meulenbelt, I. & Slagboom, P.E. (2010), A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels, European Journal of Human Genetics 18(8): 953-959.
- Callegaro, A.; Meulenbelt, I.; Kloppenburg, M.; Slagboom, P.E. & Houwing-Duistermaat, J.J. (2010), Allele-Sharing Statistics Using Information on Family History, Annals of Human Genetics 74: 547-554.
- Ruhaak, L.R.; Uh, H.W.; Beekman, M.; Koeleman, C.A.M.; Hokke, C.H.; Westendorp, R.G.J.; Wuhrer, M.; Houwing-Duistermaat, J.J.; Slagboom, P.E. & Deelder, A.M. (2010), Decreased Levels of Bisecting GlcNAc Glycoforms of IgG Are Associated with Human Longevity, PLoS ONE 5(9).
- Rozing, M.P.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Beekman, M.; Frolich, M.; Craen, A.J.M. de; Westendorp, R.G.J. & Heemst, D. van (2010), Familial Longevity Is Associated with Decreased Thyroid Function, Journal of Clinical Endocrinology and Metabolism 95(11): 4979-4984.
- Beekman, M.; Nederstigt, C.; Suchiman, H.E.D.; Kremer, D.; Breggen, R. van der; Lakenberg, N.; Alemayehu, W.G.; Craen, A.J.M. de; Westendorp, R.G.J.; Boomsma, D.I.; Geus, E.J.C. de; Houwing-Duistermaat, J.J.; Heijmans, B.T. & Slagboom, P.E. (2010), Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity, Proceedings of the National Academy of Sciences 107(42): 18046-18049.
- Landt, M.C.T.S.O. 't; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C.M.; Houwing-Duistermaat, J.J.; Trier, J. van; Onkenhout, E.J.; Vink, J.M.; Beijsterveldt, C.E.M. van; Brandys, M.K.; Sanders, N.; Zipfel, S.; Herzog, W.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; Zwaan, M. de; Herpertz, S.; Ehrlich, S.; Elburg, A.A. van; Adan, R.A.H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D.I.; Furth, E.F. van & Slagboom, P.E. (2010), Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting., Genes, Brain and Behavior.
- Vaarhorst, A.A.M.; Beekman, M.; Suchiman, E.H.D.; Heemst, D. van; Houwing-Duistermaat, J.J.; Westendorp, R.G.J.; Slagboom, P.E.; Heijmans, B.T.; Project Grp & Leiden Longevity Study LLS Grp (2010), Lipid metabolism in long-lived families: the Leiden Longevity Study., AGE.
- Talens, R.P.; Boomsma, D.I.; Tobi, E.W.; Kremer, D.; Jukema, J.W.; Willemsen, G.; Putter, H.; Slagboom, P.E. & Heijmans, B.T. (2010), Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology, FASEB Journal 24(9): 3135-3144.
- Kerkhof, H.J.M.; Lories, R.J.; Meulenbelt, I.; Jonsdottir, I.; Valdes, A.M.; Arp, P.; Ingvarsson, T.; Jhamai, M.; Jonsson, H.; Stolk, L.; Thorleifsson, G.; Zhai, G.J.; Zhang, F.; Zhu, Y.Y.; Breggen, R. van der; Carr, A.; Doherty, M.; Doherty, S.; Felson, D.T.; Gonzalez, A.; Halldorsson, B.V.; Hart, D.J.; Hauksson, V.B.; Hofman, A.; Ioannidis, J.P.A.; Kloppenburg, M.; Lane, N.E.; Loughlin, J.; Luyten, F.P.; Nevitt, M.C.; Parimi, N.; Pols, H.A.P.; Rivadeneira, F.; Slagboom, E.P.; Styrkarsdottir, U.; Tsezou, A.; Putte, T. van de; Zmuda, J.; Spector, T.D.; Stefansson, K.; Uitterlinden, A.G. & Meurs, J.B.J. van (2010), A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22, Arthritis and Rheumatism 62(2): 499-510.
- Moxley, G.; Meulenbelt, I.; Chapman, K.; Diujn, C.M. van; Slagboom, P.E.; Neale, M.C.; Smith, A.J.P.; Carr, A.J. & Loughlin, J. (2010), Interleukin-1 region meta-analysis with osteoarthritis phenotypes, Osteoarthritis and Cartilage 18(2): 200-207.
- Newman, A.B.; Walter, S.; Lunetta, K.L.; Garcia, M.E.; Slagboom, P.E.; Christensen, K.; Arnold, A.M.; Aspelund, T.; Aulchenko, Y.S.; Benjamin, E.J.; Christiansen, L.; D'Agostino, R.B.; Fitzpatrick, A.L.; Franceschini, N.; Glazer, N.L.; Gudnason, V.; Hofman, A.; Kaplan, R.; Karasik, D.; Kelly-Hayes, M.; Kiel, D.P.; Launer, L.J.; Marciante, K.D.; Massaro, J.M.; Miljkovic, I.; Nalls, M.A.; Hernandez, D.; Psaty, B.M.; Rivadeneira, F.; Rotter, J.; Seshadri, S.; Smith, A.V.; Taylor, K.D.; Tiemeier, H.; Uh, H.W.; Uitterlinden, A.G.; Vaupel, J.W.; Walston, J.; Westendorp, R.G.J.; Harris, T.B.; Lumley, T.; Duijn, C.M. van & Murabito, J.M. (2010), A Meta-analysis of Four Genome-Wide Association Studies of Survival to Age 90 Years or Older: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium, Journals of Gerontology, Series A 65(5): 478-487.
- Middeldorp, C.M.; Slof-Op 't Landt, M.C.T.; Medland, S.E.; Beijsterveldt, C.E.M. van; Bartels, M.; Willemsen, G.; Hottenga, J.J.; Geus, E.J.C. de; Suchiman, H.E.D.; Dolan, C.V.; Neale, M.C.; Slagboom, P.E. & Boomsma, D.I. (2010), Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?, Genes, Brain and Behavior 9(7): 808-816.
- Yusuf, E.; Ioan-Facsinay, A.; Bijsterbosch, J.; Kwekkeboom, J.C.; Slagboom, P.E.; Huizinga, T.W. & Kloppenburg, M. (2010), ASSOCIATION BETWEEN ADIPOKINES AND PROGRESSION OF HAND OSTEOARTHRITIS, Osteoarthritis and Cartilage 18: S58S59.
- Kerkhof, H.J.M.; Meulenbelt, I.; Carr, A.; Gonzalez, A.; Hart, D.; Hofman, A.; Kloppenburg, M.; Lane, N.E.; Loughlin, J.; Nevitt, M.C.; Pols, H.A.P.; Rivadeneira, F.; Slagboom, E.P.; Spector, T.D.; Stolk, L.; Tsezou, A.; Uitterlinden, A.G.; Valdes, A.M. & Meurs, J.B.J. van (2010), Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis, BMC Medical Genetics 11.
- Lu, Y.C.; Feskens, E.J.M.; Boer, J.M.A.; Imholz, S.; Verschuren, W.M.M.; Wijmenga, C.; Vaarhorst, A.; Slagboom, E.; Muller, M. & Dolle, M.E.T. (2010), Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study, Atherosclerosis 213(1): 200-205.
- Terracciano, A.; Sanna, S.; Uda, M.; Deiana, B.; Usala, G.; Busonero, F.; Maschio, A.; Scally, M.; Patriciu, N.; Chen, W.M.; Distel, M.A.; Slagboom, E.P.; Boomsma, D.I.; Villafuerte, S.; Sliwerska, E.; Burmeister, M.; Amin, N.; Janssens, A.C.J.W.; Duijn, C.M. van; Schlessinger, D.; Abecasis, G.R. & Costa, P.T. (2010), Genome-wide association scan for five major dimensions of personality, Molecular Psychiatry 15(6): 647-656.
- Derhovanessian, E.; Maier, A.B.; Beck, R.; Jahn, G.; Hahnel, K.; Slagboom, P.E.; Craen, A.J.M. de; Westendorp, R.G.J. & Pawelec, G. (2010), Hallmark Features of Immunosenescence Are Absent in Familial Longevity, Journal of Immunology 185(8): 4618-4624.
- Kerkhof, H.J.; Doherty, M.; Abramson, S.B.; Arden, N.K.; Attur, M.; Bos, S.; Cooper, C.; Doherty, S.A.; Evangelou, E.; Kerna, I.; Kisand, K.; Kloppenburg, M.; Maciewicz, R.A.; Meulenbelt, I.; Sezgin, M.; Slagboom, E.; Smith, A.; Spector, T.D.; Tamm, A.; Tamm, A.; Uitterlinden, A.G.; Wheeler, M.; Zhang, W.; Meurs, J.B. van & Valdes, A.M. (2010), LARGE SCALE META-ANALYSIS OF INTERLEUKIN-1 BETA AND INTERLEUKIN-1 RECEPTOR ANTAGONIST POLYMORPHISMS ON RISK OF RADIOGRAPHIC HIP AND KNEE OSTEOARTHRITIS AND SEVERITY OF KNEE OSTEOARTHRITIS, Osteoarthritis and Cartilage 18: S166S166.
- Caliebe, A.; Kleindorp, R.; Blanche, H.; Christiansen, L.; Puca, A.A.; Rea, I.M.; Slagboom, E.; Flachsbart, F.; Christensen, K.; Rimbach, G.; Schreiber, S. & Nebel, A. (2010), No or only population-specific effect of PON1 on human longevity: A comprehensive meta-analysis, Ageing Research Reviews 9(3): 238-244.
- May, L.; Bodegom, D. van; Frolich, M.; Lieshout, L. van; Slagboom, P.E.; Westendorp, R.G.J. & Kuningas, M. (2010), Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana, European Journal of Human Genetics 18(4): 490-495.
- Kerkhof, H.J.; Meulenbelt, I.; Arden, N.; Cooper, C.; Doherty, M.; Felson, D.; Gonzalez, A.; Ikegawa, S.; Jiang, Q.; Jonsdottir, I.; Kujala, U.; Lane, N.; Leino-Arjas, P.; Lohmander, S.; Luyten, F.; Nevitt, M.; Slagboom, E.; Spector, T.; Stefansson, K.; Tamm, A.; Tsezou, A.; Wilkinson, J.; Yoshimura, N.; Valdes, A. & Meurs, J. van (2010), RECOMMENDATIONS FOR STANDARDIZATION AND PHENOTYPE DEFINITIONS IN GENETIC STUDIES OF OSTEOARTHRITIS: THE TREAT-OA CONSORTIUM, Osteoarthritis and Cartilage 18: S160S160.
- Panoutsopoulou, K.; Southam, L.; Rayner, W.; Zhai, G.; Beazley, C.; Arden, N.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Olher, W.; Ralston, S.; Spector, T.; Valdes, A.; Wallis, G.; Wilkinson, M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F.; Bumpstead, S.; Cupples, A.; Day-Williams, A.; Dixon, K.; Dohertys, S.; Elliott, K.; Evangelou, E.; Felson, D.; Gomez-Reino, J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Hofman, A.; Hunt, S.; Ioannidis, J.; Jonsdottir, I.; Keen, R.; Kerkhof, H.; Kloppenburg, M.; Koller, N.; Lakenberg, N.; Lane, N.; Lee, A.; Meulenbelt, I.; Nevitt, M.; O'Neill, F.; Parimi, N.; Potter, S.; Rego-Perez, I.; Riancho, J.; Sherburn, K.; Slagboom, E.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Tsezou, A.; Uitterlinden, A.; Meurs, J. van; Watkins, B.; Wheeler, M.; Mitchelle, S.; Zhu, Y.; Zmuda, J.; Zeggini, E.; Loughlin, J. & ArcOGEN Consortium (2010), THE arcOGEN CONSORTIUM: STAGE 1 OF A GENOME-WIDE ASSOCIATION SCAN FOR OSTEOARTHRITIS, Osteoarthritis and Cartilage 18: S166S167.
- Middeldorp, C.M.; Geus, E.J.C. de; Willemsen, G.; Hottenga, J.J.; Slagboom, P.E. & Boomsma, D.I. (2010), The Serotonin Transporter Gene Length Polymorphism (5-HTTLPR) and Life Events: No Evidence for an Interaction Effect on Neuroticism and Anxious Depressive Symptoms, Twin Research and Human Genetics 13(6): 544-549.
- Mooijaart, S.P.; Heemst, D. van; Noordam, R.; Rozing, M.P.; Wijsman, C.A.; Craen, A.J.M. de; Westendorp, R.G.J.; Beekman, M. & Slagboom, P.E. (2010), Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study., Aging.
- Trompet, S.; Craen, A.J.M. de; Jukema, J.W.; Pons, D.; Slagboom, P.E.; Kremer, D.; Bonen, E.L.E.M. & Westendorp, R.G.J. (2010), Variation in the CBP gene involved in epigenetic control associates with cognitive function.
- Bos, S.D.; Lakenberg, N.; Breggen, R. van der; Houwing-Duistermaat, J.J.; Kloppenburg, M.; Craen, A.J.M. de; Beekman, M.; Meulenbelt, I. & Slagboom, P.E. (2010), A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels, European Journal of Human Genetics 18(8): 953-959.
- Derhovanessian, E.; Maier, A.B.; Beck, R.; Jahn, G.; Hahnel, K.; Slagboom, P.E.; Craen, A.J.M. de; Westendorp, R.G.J. & Pawelec, G. (2010), Hallmark Features of Immunosenescence Are Absent in Familial Longevity, Journal of Immunology 185(8): 4618-4624.
- Rozing, M.P.; Westendorp, R.G.J.; Craen, A.J.M. de; Frolich, M.; Heijmans, B.T.; Beekman, M.; Wijsman, C.; Mooijaart, S.P.; Blauw, G.J.; Slagboom, P.E.; Heemst, D. van & LLS Grp (2010), Low Serum Free Triiodothyronine Levels Mark Familial Longevity: The Leiden Longevity Study, Journals of Gerontology, Series A 65(4): 365-368.
- Bijsterbosch, J.; Wassenaar, M.J.E.; Cessie, S. le; Slagboom, P.E.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2010), Doyle Index is a valuable additional pain measure in osteoarthritis, Osteoarthritis and Cartilage 18(8): 1046-1050.
- Hart, L.M. 't; Simonis-Bik, A.M.; Nijpels, G.; Haeften, T.W. van; Schafer, S.A.; Houwing-Duistermaat, J.J.; Boomsma, D.I.; Groenewoud, M.J.; Reiling, E.; Hove, E.C. van; Diamant, M.; Kramer, M.H.H.; Heine, R.J.; Maassen, J.A.; Kirchhoff, K.; Machicao, F.; Haring, H.U.; Slagboom, P.E.; Willemsen, G.; Eekhoff, E.M.; Geus, E.J. de; Dekker, J.M. & Fritsche, A. (2010), Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.
- Ruhaak, L.R.; Uh, H.W.; Beekman, M.; Hokke, C.H.; Westendorp, R.G.J.; Houwing-Duistermaat, J.; Wuhrer, M.; Deelder, A.M. & Sagboom, P.E. (2010), Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health., Journal of Proteome Research.
- Willemsen, G.; Geus, E.J.C. de; Bartels, M.; Beijsterveldt, C.E.M.T. van; Brooks, A.I.; Estourgie-van Burk, G.F.; Fugman, D.A.; Hoekstra, C.; Hottenga, J.J.; Kluft, K.; Meijer, P.; Montgomery, G.W.; Rizzu, P.; Sondervan, D.; Smit, A.B.; Spijker, S.; Suchiman, H.E.D.; Tischfield, J.A.; Lehner, T.; Slagboom, P.E. & Boomsma, D.I. (2010), The Netherlands Twin Register Biobank: A Resource for Genetic Epidemiological Studies, Twin Research and Human Genetics 13(3): 231-245.
- Reiling E, van Vliet-Ostaptchouk JV, van 't Riet E, van Haeften TW, Arp PA, Hansen T, Kremer D, Groenewoud MJ, van Hove EC, Romijn JA, Smit JW, Nijpels G, Heine RJ, Uitterlinden AG, Pedersen O, Slagboom PE, Maassen JA, Hofker MH, 't Hart LM & Dekker JM (2009), Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study., European Journal of Human Genetics 17(8): 1056-62.
- Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gomez-Reino JJ & Gonzalez A (2009), Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand, Arthritis and Rheumatism 60(6): 1710-1721.
- Dieguez-Gonzalez R, Calaza M, Shi D, Meulenbelt I, Loughlin J, Tsezou A, Dai J, Malizos KN, Slagboom EP & Kloppenburg M (2009), Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections, Annals of the Rheumatic Diseases 68(6): 1017-1021.
- Bos SD, Kloppenburg M, Suchiman E, van Beelen E, Slagboom PE & Meulenbelt I (2009), The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA, Osteoarthritis and Cartilage 17(5): 621-626.
- Vink JM, Smit AB, de Geus EJC, Sullivan P, Willemsen G, Hottenga JJ, Smit JH, Hoogendijk WJ, Zitman FG, Peltonen L, Kaprio J, Pedersen NL, Magnusson PK, Spector TD, Kyvik KO, Morleyis KI, Heath AC, Martin NG, Westendorp RGJ, Slagboom PE, Tiemeier H, Hofman A, Uitterlinden AG, Aulchenko YS, Amin N, van Duijn C, Penninx BW & Boomsma DI (2009), Genome-wide Association Study of Smoking Initiation and Current Smoking, American Journal of Human Genetics 84(3): 367-379.
- Westendorp RGJ, van Heemst D, Rozing MP, Frolich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJM & Slagboom PE (2009), Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study, Journal of the American Geriatrics Society 57(9): 1634-1637.
- Kuningas M, May L, Tamm R, van Bodegom D, van den Biggelaar AHJ, Meij JJ, Frolich M, Ziem JB, Suchiman HED, Metspalu A, Slagboom PE & Westendorp RGJ (2009), Selection for Genetic Variation Inducing Pro-Inflammatory Responses under Adverse Environmental Conditions in a Ghanaian Population, PLoS ONE 4(11): A174A180.
- Kuningas M, Mooijaart SP, Jolles J, Slagboom PE, Westendorp RGJ & van Heemst D (2009), VDR gene variants associate with cognitive function and depressive symptoms in old age, Neurobiology of Aging 30(3): 466-473.
- Houwing-Duistermaat JJ, Callegaro A, Beekman M, Westendorp RG, Slagboom PE & van Houwelingen JC (2009), Weighted statistics for aggregation and linkage analysis of human longevity in selected families: The Leiden Longevity Study, Statistics in Medicine 28(1): 140-151.
- Rozing MP, Westendorp RG, Frölich M, de Craen AJ, Beekman M, Heijmans BT, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D & Group OB (2009), Human insulin/IGF-1 and familial longevity at middle age., Aging 1(8): 714-22.
- Reiling E, van Vliet-Ostaptchouk JV, van't Riet E, van Haeften TW, Arp PA, Hansen T, Kremer D, Groenewoud MJ, van Hove EC & Romijn JA (2009), Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study, European Journal of Human Genetics 17(8): 1056-1062.
- Finken MJJ, Meulenbelt I, Dekker FW, Frolich M, Romijn J, Slagboom E & Wit JM (2009), Adverse body composition in adult life after perinatal glucocorticoid therapy in prematurely born individuals carrying the 363S variant of the N363S polymorphism in the glucocorticoid receptor gene, Hormone Research 72: 426-426.
- Slof-Op 't Landt MCT, van Furth EF, Rebollo-Mesa I, Bartels M, van Beijsterveldt CEM, Slagboom PE, Boomsma DI, Meulenbelt I & Dolan CV (2009), Sex Differences in Sum Scores May Be Hard to Interpret The Importance of Measurement Invariance, Assessment 16(4): 415-423.
- Rodriguez-Lopez J, Pombo-Suarez M, Loughlin J, Tsezou A, Blanco FJ, Meulenbelt I, Slagboom PE, Valdes AM, Spector TD & Gomez-Reino JJ (2009), Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes, Osteoarthritis and Cartilage 17(3): 321-327.
- Steegers-Theunissen RP, Borst SA, Kremer D, Lindemans J, Siebel C, Steegers EA, Slagboom E & Heijmans BT (2009), Epigenetic Changes after Periconception Folic Acid Supplementation in Humans, Reproductive Sciences 16(3): 97A97A.
- Sampietro ML, Pons D, de Knijff P, Slagboom PE, Zwinderman AH & Jukema JW (2009), A genome wide association analysis in the GENDER study, Netherlands Heart Journal 17(6): 262-264.
- Kerkhof HJM, Jonsdottir I, Meulenbelt I, Stolk L, Valdes AM, Zhai G, Zhu Y, Doherty M, Doherty S, Tsezou A, Gonzalez A, Carr A, Felson DT, Styrkarsdottir U, Slagboom EP, Loughlin J, Rivadeneira F, Hofman A, Pols HAP, Spector TD, Uitterlinden AG & van Meurs JBJ (2009), A genome-wide association study identifies a common variant near the GRP22 gene as a new locus involved in prevalence and progression of osteoarthritis, BONE 44(2): S224S224.
- Tobi EW, Lumey L, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE & Heijmans BT (2009), DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific, Human Molecular Genetics 18(21): 4046-4053.
- Lescai F, Blanche H, Nebel A, Beekman M, Sahbatou M, Flachsbart F, Slagboom E, Schreiber S, Sorbi S, Passarino G & Franceschi C (2009), Human longevity and 11p15.5: a study in 1321 centenarians, European Journal of Human Genetics 17(11): 1515-1519.
- Kettunen J, Perola M, Martin NG, Cornes BK, Wilson SG, Montgomery GW, Benyamin B, Harris JR, Boomsma D, Willemsen G, Hottenga JJ, Slagboom PE, Christensen K, Kyvik KO, Sorensen TIA, Pedersen NL, Magnusson PKE, Andrew T, Spector TD, Widen E, Silventoinen K, Kaprio J, Palotie A & Peltonen L (2009), Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci, International Journal of Obesity 33(11): 1235-1242.
- Middeldorp CM, Sullivan PF, Wray NR, Hottenga JJ, de Geus EJC, van den Berg M, Montgomery GW, Coventry WL, Statham DJ, Andrews G, Slagboom PE, Boomsma DI & Martin NG (2009), Suggestive Linkage on Chromosome 2, 8, and 17 for Lifetime Major Depression.
- Uh HW, Beekman M, Slagboom PE & Houwing-Duistermaat JJ (2009), Testing for genetic association using family data: incorporating phenotypic information of un-genotyped relatives, Annals of Human Genetics 73: 662-662.
- Heijmans BT, Tobi EW, Lumey LH & Slagboom PE (2009), The epigenome Archive of the prenatal environment, Epigenetics 4(8): 526-531.
- Botha-Scheepers S, Riyazi N, Watt I, Rosendaal FR, Slagboom E, Bellamy N, Breedveld FC & Kloppenburg M (2009), Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study., Annals of the Rheumatic Diseases 68(8): 1260-4.
- null
- Heijmans BT, Tobi EW, Lumey LH & Slagboom PE (2009), The epigenome: archive of the prenatal environment., Epigenetics 4(8): 526-31.
- Steegers-Theunissen RP, Obermann-Borst SA, Kremer D, Lindemans J, Siebel C, Steegers EA, Slagboom PE & Heijmans BT (2009), Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child., PLoS ONE 4(11): e7845.
- Meulenbelt I, Chapman K, Dieguez-Gonzalez R, Shi DQ, Tsezou A, Dai J, Malizos KN, Kloppenburg M, Carr A & Nakajima M (2009), Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations, Human Molecular Genetics 18(8): 1518-1523.
- Tobi EW, Lumey LH, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE & Heijmans BT (2009), DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific., Human Molecular Genetics 18(21): 4046-53.
- Westendorp RG, van Heemst D, Rozing MP, Frölich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJ, Slagboom PE & (2009), Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study., Journal of the American Geriatrics Society 57(9): 1634-7.
- May L, van Bodegom D, Frölich M, van Lieshout L, Slagboom PE, Westendorp RG & Kuningas M (2009), Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana., European Journal of Human Genetics.
- Kuningas M, May L, Tamm R, van Bodegom D, van den Biggelaar AH, Meij JJ, Frölich M, Ziem JB, Suchiman HE, Metspalu A, Slagboom PE & Westendorp RG (2009), Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population., PLoS ONE 4(11): e7795.
- Albers HM, Kurreeman FAS, Stoeken-Rijsbergen G, Brinkman DMC, Kamphuis SSM, van Rossum MAJ, Girschick HJ, Wouters C, Saurenmann RK, Hoppenreijs E, Slagboom P, Houwing-Duistermaat JJ, Verduijn W, Huizinga TWJ, ten Cate R, Toes REM & Schilham MW (2009), Association of the Autoimmunity Locus 4q27 With Juvenile Idiopathic Arthritis, Arthritis and Rheumatism 60(3): 901-904.
- Sampietro ML, Pons D, de Knijff P, Slagboom PE, Zwinderman A & Jukema JW (2009), A genome wide association analysis in the GENDER study., Netherlands Heart Journal 17(6): 262-4.
- Zhai G, van Meurs JBJ, Livshits G, Meulenbelt I, Valdes AM, Soranzo N, Hart D, Zhang F, Kato BS, Richards JB, Williams FM, Inouye M, Kloppenburg M, Deloukas P, Slagboom E, Uitterlinden A & Spector TD (2009), A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium, Journal of Medical Genetics 46(9): 614-616.
- Albers HM, Kurreeman FA, Stoeken-Rijsbergen G, Brinkman DM, Kamphuis SS, van Rossum MA, Girschick HJ, Wouters C, Saurenmann RK, Hoppenreijs E, Slagboom P, Houwing-Duistermaat JJ, Verduijn W, Huizinga TW, Ten Cate R, Toes RE & Schilham MW (2009), Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis., Arthritis and Rheumatism 60(3): 901-4.
- Houwing-Duistermaat JJ, Callegaro A, Beekman M, Westendorp RG, Slagboom PE & van Houwelingen JC (2009), Weighted statistics for aggregation and linkage analysis of human longevity in selected families: the Leiden Longevity Study., Statistics in Medicine 28(1): 140-51.
- Meulenbelt I, Chapman K, Dieguez-Gonzalez R, Shi D, Tsezou A, Dai J, Malizos KN, Kloppenburg M, Carr A, Nakajima M, van der Breggen R, Lakenberg N, Gomez-Reino JJ, Jiang Q, Ikegawa S, Gonzalez A, Loughlin J & Slagboom EP (2009), Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations., Human Molecular Genetics 18(8): 1518-23.
- Botha-Scheepers S, Riyazi N, Watt I, Rosendaal FR, Slagboom E, Bellamy N, Breedveld FC & Kloppenburg M (2009), Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study, Annals of the Rheumatic Diseases 68(8): 1260-1264.
- Bos SD, Kloppenburg M, Suchiman E, van Beelen E, Slagboom PE & Meulenbelt I (2009), The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA., Osteoarthritis and Cartilage 17(5): 621-6.
- Ghidey W, Stijnen T, Houwing-Duistermaat JJ, Heijmans BT, Beekman M, Westendorp RGJ, Slagboom PE & van Houwelingen HC (2008), Prediction models for SNP data, Annals of Human Genetics 72.
- Bos SD, Slagboom PE & Meulenbelt I (2008), New insights into osteoarthritis: early developmental features of an ageing-related disease, Current Opinion in Rheumatology 20(5).
- Bos SD, Suchiman HED, Kloppenburg M, Houwing-Duistermaat JJ, le Graverand MPH, Seymour AB, Kroon HM, Slagboom PE & Meulenbelt I (2008), Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study, Annals of the Rheumatic Diseases 67(6).
- Trompet, S.; Craen, A.J.M. de; Slagboom, P.; Shepherd, J.; Blauw, G.J.; Murphy, M.B.; Bollen, E.L.E.M.; Buckley, B.M.; Ford, I.; Gaw, A.; Macfarlane, P.W.; Packard, C.J.; Stott, D.J.; Westendorp, R.G.J.; Jukema, J.W. & PROSPER Grp (2008), Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study, Experimental Gerontology 43(8).
- Uh HW, Beekman M, Slagboom PE & Duistermaat JJH (2008), Testing for genetic association in an affected sibling pair - control design taking into account phenotypic information of relatives, Genetic Epidemiology 32(7).
- Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, Susser ES, Slagboom PE & Lumey LH (2008), Persistent epigenetic differences associated with prenatal exposure to famine in humans, Proceedings of the National Academy of Sciences 105(44).
- Meulenbelt I, Min JL, Bos S, Riyazi N, Houwing-Duistermaat JJ, van der Wijk HJ, Kroon HM, Nakajima M, Ikegawa S, Uitterlinden AG, van Meurs JBJ, van der Deure WM, Visser TJ, Seymour AB, Lakenberg N, van der Breggen R, Kremer D, van Duijn CM, Kloppenburg M, Loughlin J & Slagboom PE (2008), Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis, Human Molecular Genetics 17(12).
- Middeldorp CM, Hottenga JJ, Slagboom PE, Sullivan PF, de Geus EJC, Posthuma D, Willemsen G & Boomsma DI (2008), Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype, Molecular Psychiatry 13(1).
- Trompet S, de Craen AJM, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Bollen ELEM, Buckley BM, Ford I, Gaw A, Macfarlane PW, Packard CJ, Stott DJ, Jukema JW & Westendorp RGJ (2008), Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study, Brain 131.
- 't Landt MCTSO, Bartels M, van Furth EF, van Beijsterveldt CEM, Meulenbelt I, Slagboom PE & Boomsma DI (2008), Genetic influences on disordered eating behaviour are largely independent of body mass index.
- Wray NR, Middeldorp CM, Birley AJ, Gordon SD, Sullivan PF, Visscher PM, Nyholt DR, Willemsen G, de Geus EJC, Slagboom PE, Montgomery GW, Martin NG & Boomsma DI (2008), Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands, Archives of General Psychiatry 65(6).
- Slagboom E & Meulenbelt I (2008), Genetics of osteoarthritis: early developmental clues to an old disease, Nature Clinical Practice Rheumatology 4(11).
- Colas F, Meulenbelt I, Houwing-Duistermaat JJ, Slagboom PE & Kok JN (2008), A comparison of two methods for finding groups using heat maps and model based clustering, APPLICATIONS AND INNOVATIONS IN INTELLIGENT SYSTEMS XV: 119-131.
- Colas F, Meulenbelt I, Houwing-Duistermaat JJ, Kloppenburg M, Watt I, van Rooden SA, Visser M, Marinus J, Cannon EO, Bender A, van Hilten JJ, Slagboom PE & Kok JN (2008), A Scenario Implementation in R for SubtypeDiscovery Examplified on Chemoinformatics Data, LEVERAGING APPLICATIONS OF FORMAL METHODS, VERIFICATION AND VALIDATION, PROCEEDINGS 17: 669-683.
- Colas F, Meulenbelt I, Houwing-Duistermaat JJ, Kloppenburg M, Watt I, van Rooden SM, Visser M, Marinus J, van Hilten JJ, Slagboom PE & Kok JN (2008), Reliability of Cluster Results for Different Types of Time Adjustments in Complex Disease Research, 2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8: 4601-4604.
- Macgregor S, Hottenga JJ, Lind PA, Suchiman HED, Willemsen G, Slagboom PE, Montgomery GW, Martin NG, Visscher PM & Boomsma DI (2008), Vitamin D Receptor Gene Polymorphisms Have Negligible Effect on Human Height, Twin Research and Human Genetics 11(5).
- Botha-Scheepers S, Watt I, Slagboom E, de Craen AJM, Meulenbelt I, Rosendaal FR, Breedveld FC, Huizinga TWJ & Kloppenburg M (2008), Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis, Annals of the Rheumatic Diseases 67(8).
- Riyazi N, Rosendaal FR, Slagboom E, Kroon HM, Breedveld FC & Kloppenburg M (2008), Risk factors in familial osteoarthritis: the GARP sibling study, Osteoarthritis and Cartilage 16(6).
- Passtoors WM, Beekman M, Gunn D, Boer JM, Heijmans BT, Westendorp RGJ, Zwaan BJ & Slagboom PE (2008), Genomic studies in ageing research: the need to integrate genetic and gene expression approaches, Journal of Internal Medicine 263(2).
- Kuningas, M.; Mooijaart, S.P.; Heemst, D. van; Zwaan, B.J.; Slagboom, P.E. & Westendorp, R.G.J. (2008), Genes encoding longevity: from model organisms to humans, Aging Cell 7(2).
- Ghidey W, Stijnen T, Houwing-Duistermaat J, Heijmans B, Beekman M, Westendorp R, Slagboom E & van Houwelingen HC (2008), Predicting a binary outcome using SNPs: a case study on prediction of longevity, Genetic Epidemiology 32(7).
- Shifman S, Bhomra A, Smiley S, Wray NR, James MR, Martin NG, Hettema JM, An SS, Neale MC, Van den Oord EJCG, Kendler KS, Chen X, Boomsma DI, Middeldorp CM, Hottenga JJ, Slagboom PE & Flint J (2008), A whole genome association study of neuroticism using DNA pooling, Molecular Psychiatry 13(3).
- Chapman K, Takahashi A, Meulenbelt I, Watson C, Rodriguez-Lopez J, Egli R, Tsezou A, Malizos KN, Kloppenburg M, Shi DQ, Southam L, van der Breggen R, Donn R, Qin JH, Doherty M, Slagboom PE, Wallis G, Kamatani N, Jiang Q, Gonzalez A, Loughlin J & Ikegawa S (2008), A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5 ' UTR of GDF5 with osteoarthritis susceptibility, Human Molecular Genetics 17(10).
- Slagboom PE, Heijmans BT, Beekman M & Meulenbelt I (2007), Molecular epidemiology, candidate genes versus genome-wide scans, Genes and Nutrition 2(1).
- Botha-Scheepers S, Watt I, Slagboom E, Craen AJM, Meulenbelt I, Rosendaal F, Breedveld FC, Huizinga TWJ & Kloppenburg M (2007), Innate production of tumor necrosis factor-alpha and interleukin-10 is associated with radiological progression of knee osteoarthritis, Annals of the Rheumatic Diseases 66.
- Loughlin J, Meulenbelt I, Min J, Mustafa Z, Sinsheimer JS, Carr A & Slagboom PE (2007), Genetic association analysis of RHOB and TXNDC3 in osteoarthritis, American Journal of Human Genetics 80(2).
- Heijmans BT, Kremer D, Tobi EW, Boomsma DI & Slagboom PE (2007), Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus, Human Molecular Genetics 16(5).
- Middeldorp CM, de Geus EJC, Beem AL, Lakenberg N, Hottenga JJ, Slagboom PE & Boomsma DI (2007), Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression, Behavior Genetics 37(2).
- Kuningas, M.; Rijk, R.H. de; Westendorp, R.G.J.; Jolles, J.; Slagboom, P.E. & Heemst, D. van (2007), Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors, Neuropsychopharmacology 32(6).
- Trompet S, Pons D, De Craen AJM, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen ELEM, Buckley BM, Ford I, Hyland M, Gaw A, Macfarlane PW, Packard CJ, Norrie J, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RGJ & Jukema JW (2007), Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events - The PROSPER study, Annals of the New York Academy of Sciences 1100.
- Mooijaart, S.P.; Kuningas, M.; Westendorp, R.G.J.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Rensen, P.C.N. & Heemst, D. van (2007), Liver X receptor alpha associates with human life span, The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences 62(4).
- Bakaysa SL, Mucci LA, Slagboom PE, Boomsma DI, McClearn GE, Johansson B & Pedersen NL (2007), Telomere length predicts survival independent of genetic influences, Aging Cell 6(6).
- Kurreeman FAS, Verpoort KN, Ioan-Facsinay A, Schonkeren JJM, Uh H, Slagboom E, Westendorp R, Toes REM & Huizinga TWJ (2007), The association between IL10 and joint destruction in RA can be attributed to enhanced autoantibody responses, Annals of the Rheumatic Diseases 66.
- Botha-Scheepers S, Riyazi N, Watt I, Rosendaal FR, Slagboom E, Bellamy N, Breedveld FC & Kloppenburg M (2007), Progression of hand osteoarthritis over two years: A clinical and radiological follow-up study, Annals of the Rheumatic Diseases 66.
- Thabet MM, Wesoly J, Slagboom PE, Toes REM & Huizinga TWJ (2007), FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians, Annals of the Rheumatic Diseases 66(6).
- Botha-Scheepers SA, Watt I, Slagboom E, Meulenbelt I, Rosendaal FR, Breedveld FC & Kloppenburg M (2007), Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: A prospective longitudinal cohort study, Arthritis and Rheumatism 57(4).
- Kurreeman FAS, Verpoort KN, Ioan-Facsinay A, Schonkeren JJM, Uh HW, Slagboom E, Westendorp RG, Toes REM & Huizinga TWJ (2007), The association between IL10 and joint destruction in RA can be attributed to enhanced autoantibody responses, Annals of the Rheumatic Diseases 66.
- Margarita, C.T.; Landt, S.O.T.; Bartels, M.; Furth, E.F. van; Meulenbelt, I.; Slagboom, E. & Boomsma, D.I. (2007), Genetic influences on disordered eating behavior are largely independent of BMI, Behavior Genetics 37(6): 794-794.
- Hottenga JJ, Suchiman E, Willemsen G, Slagboom E & Boomsma DI (2007), The vitamin D receptor gene is not strongly associated with stature: Results from the Netherlands twin register, Behavior Genetics 37(6): 763-763.
- Trompet, S.; Pons, D.; Craen, A.J.M. de; Slagboom, P.; Shepherd, J.; Blauw, G.J.; Murphy, M.B.; Cobbe, S.M.; Bollen, E.L.E.M.; Buckley, B.M.; Ford, I.; Hyland, M.; Gaw, A.; Macfarlane, P.W.; Packard, C.J.; Norrie, J.; Perry, I.J.; Stott, D.J.; Sweeney, B.J.; Twomey, C.; Westendorp, R.G.J.; Jukema, J.W.; PROSPER Grp; Rattan, S.I.S. & Akman, S. (2007), Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study., Annals of the New York Academy of Sciences 1100: 189-98.
- Houwing-Duistermaat JJ, Callegaro A, Beekman M, Westendorp RGJ, Slagboom E & van Houwelingen JC (2007), A score statistic for linkage analysis of censored outcomes applied to a candidate region at chromosome 4 for human longevity, Genetic Epidemiology 31(5).
- Sahiratmadja E, Wieringa FT, van Crevel R, de Visser AW, Adnan I, Alisjahbana B, Slagboom E, Marzuki S, Ottenhoff THM, van de Vosse E & Marx JJA (2007), Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3/UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population, British Journal of Nutrition 98(4).
- Houwing-Duistermaat JJ, Helmer Q, Heijmans BT, Beekman M & Slagboom PE (2007), Selection of informative SNPs for sibling pair linkage analysis from large SNP arrays, Genetic Epidemiology 31(6).
- Kuningas, M.; Magi, R.; Westendorp, R.G.J.; Slagboom, P.E.; Remm, M. & Heemst, D. van (2007), Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age, European Journal of Human Genetics 15(3).
- Lambert JC, Ferreira S, Gussekloo J, Christiansen L, Brysbaert G, Slagboom E, Cottel D, Petit T, Hauw J, DeKosky ST, Richard F, Berr C, Lendon C, Kamboh MI, Mann D, Christensen K, Westendorp R & Amouyel P (2007), Evidence for the association of the S100 beta gene with low cognitive performance and dementia in the elderly, Molecular Psychiatry 12(9).
- Finken MJJ, Meulenbelt I, Dekker FW, Frolich M, Romijn JA, Slagboom PE & Wit JM (2007), The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth, Journal of Clinical Endocrinology and Metabolism 92(12).
- Pons D, Monraats PS, de Vries FR, de Maat MP, Zwinderman AH, de Winter RJ, Doevendans PAFM, Tio RA, Frants RR, Heijmans BT, Slagboom PE, van der Laarse A, van der Wall EE & Jukema JW (2007), Involvement of EPIgenetic variation in restenosis after PCI, Journal of the American College of Cardiology 49(9).
- Alizadeh BZ, Njajou OT, Hazes JMW, Hofman A, Slagboom PE, Pols HAP & van Duijn CM (2007), The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis, Annals of the Rheumatic Diseases 66(11).
- Ali S, Vollaard AM, Kremer D, de Visser AW, Martina CAE, Widjaja S, Surjadi C, Slagboom E, van de Vosse E & Van Dissel JT (2007), Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever, Journal of Interferon and Cytokine Research 27(4).
- Min JL, Meulenbelt I, Kloppenburg M, van Duijn CM & Slagboom PE (2007), Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis, European Journal of Human Genetics 15(7).
- Meulenbelt I, Kloppenburg M, Kroon HM, Houwing-Duistermaat JJ, Garnero P, Hellio-Le Graverand MP, DeGroot J & Slagboom PE (2007), Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study, Osteoarthritis and Cartilage 15(4).
- Mooijaart, S.P.; Berbee, J.F.P.; Heemst, D. van; Havekes, L.M.; Craen, A.J.M. de; Slagboom, P.E.; Rensen, P.C.N. & Westendorp, R.G.J. (2006), ApoE plasma levels and risk of cardiovascular mortality in old age, PLoS Medicine 3(6): 874-883.
- Kuningas, M.; Mooijaart, S.P.; Slagboom, P.E.; Westendorp, R.G.J. & Heemst, D. van (2006), Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study, Biogerontology 7(4).
- Wessels JAM, de Vries-Bouwstra JK, Heijmans BT, Slagboom PE, Goekoop-Ruiterman YPM, Allaart CF, Kerstens PJSM, van Zeben D, Breedveld FC, Dijkmans BAC, Huizinga TWJ & Guchelaar HJ (2006), Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes, Arthritis and Rheumatism 54(4).
- Posthuma D, Visscher PM, Willemsen G, Zhu G, Martin NG, Slagboom PE, de Geus EJC & Boomsma DI (2006), Replicated linkage for eye color on 15q using comparative ratings of sibling pairs, Behavior Genetics 36(1).
- Beem AL, de Geus EJC, Hottenga JJ, Sullivan PF, Willemsen G, Slagboom PE & Boomsma DI (2006), Combined linkage and association analyses of the 124-bp allele of marker D2S2944 with anxiety, depression, neuroticism and major depression, Behavior Genetics 36(1).
- Boomsma DI, Cacioppo JT, Slagboom PE & Posthuma D (2006), Genetic linkage and association analysis for loneliness in Dutch twin and sibling pairs points to a region on chromosome 12q23-24, Behavior Genetics 36(1).
- Beekman M, Blauw GJ, Houwing-Duistermaat JJ, Brandt BW, Westendorp RGJ & Slagboom PE (2006), Chromosome 4q25, microsomal transfer protein gene, and human longevity: Novel data and a meta-analysis of association studies, Journals of Gerontology, Series A 61(4).
- Valle A, O'Connor DT, Taylor P, Zhu G, Montgomery GW, Slagboom PE, Martin NG & Whitfield JB (2006), Butyrylcholinesterase: Association with the metabolic syndrome and identification of 2 gene loci affecting activity, Clinical Chemistry 52(6).
- Min JL, Lakenberg N, Bakker-Verweij M, Suchiman E, Boomsma DI, Slagboom PE & Meulenbelt I (2006), High microsatellite and SNP genotyping success rates established in a large number of genomic DNA samples extracted from mouth swabs and genotypes, Twin Research and Human Genetics 9(4).
- Min J, Meulenbelt I & Slagboom E (2006), Replication in genetic association studies: comment on the editorial by Spector et al, Arthritis and Rheumatism 54(9).
- Botha-Scheepers S, Watt I, Slagboom E, de Craen T, Meulenbelt I, Rosendaal FR, Breedveld FC, Huizinga TWJ & Kloppenburg M (2006), Innate production of tumor necrosis factor-alpha and interleukin-10 upon lipopolysaccharide stimulation are associated with radiological progression of knee osteoarthritis., Arthritis and Rheumatism 54(9).
- Meulenbelt I, Kloppenburg M, Houwing-Duistermaat JJ, Garnero P, Le Graverand MH, DeGroot J & Slagboom PE (2006), Biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial oa at multiple sites. The GARP study, Annals of the Rheumatic Diseases 65: 589-589.
- Heijmans BT, Beekman M, Houwing-Duistermaat JJ, Cobain MR, Powell J, Blauw GJ, van der Ouderaa F, Westendorp RGJ & Slagboom PE (2006), Lipoprotein particle profiles mark familial and sporadic human longevity, PLoS Medicine 3(12): 2317-2323.
- Pons D, Monraats PS, de Vries FR, Zwinderman AH, de Maat MPM, Slagboom PE, Agema WRR, Doevendans PAFM, de Winter RJ, Tio RA, Waltenberger J, Frants RR, van der Laarse A, van der Wall EE & Jukema JW (2006), Different genetic make-up of the anti-inflammatory II10-gene contributes to the development of restenosis after PCI, Journal of the American College of Cardiology 47(4): 317A-317A.
- Min JL, Meulenbelt I, Riyazi N, Putter H, Seymour A, Lakenberg N, Van Duijn C, Kloppenburg M & Slagboom E (2006), Genetic linkage analysis of osteoarthritis at multiple joint sites in Dutch sibpairs, Annals of the Rheumatic Diseases 65: 75-75.
- Dahaghin S, Alizadeh B, Bierma-Zeinstra S, Koes B, Slagboom P, Pols H, Van Duijn C, Njajou O & Hazes J (2006), Should patients with osteoarthritis of the metacarpophalangeal joints be screened for hereditary hemochromatosis gene (HFE) mutations?, Annals of the Rheumatic Diseases 65: 228-228.
- Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, van Duijn CM & Slagboom PE (2006), Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand, Annals of the Rheumatic Diseases 65(8).
- Schoenmaker M, de Craen AJM, de Meijer PHEM, Beekman M, Blauw GJ, Slagboom PE & Westendorp RGJ (2006), Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study, European Journal of Human Genetics 14(1).
- Meulenbelt I, Kloppenburg M, Kroon HM, Houwing-Duistermaat JJ, Garnero P, Le Graverand MPH, DeGroot J & Slagboom PE (2006), Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study, Annals of the Rheumatic Diseases 65(3).
- Meulenbelt I, Min JL, van Duijn CM, Kloppenburg M, Breedveld FC & Slagboom PE (2006), Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes, European Journal of Human Genetics 14(12).
- Botha-Scheepers S, Riyazi N, Kroon HM, Scharloo M, Houwing-Duistermaat JJ, Slagboom E, Rosendaal FR, Breedveld FC & Kloppenburg M (2006), Activity limitations in the lower extremities in patients with osteoarthritis: the modifying effects of illness perceptions and mental health, Osteoarthritis and Cartilage 14(11).
- Kuningas, M.; Slagboom, P.E.; Westendorp, R.G.J. & Heemst, D. van (2006), Impact of genetic variations in the WRN gene on age related pathologies and mortality, Mechanisms of Ageing and Development 127(3).
- Posthuma D, Meulenbelt I, de Craen AJM, de Geus EJC, Slagboom PE, Boomsma DI & Westendorp RGJ (2005), Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors, Twin Research and Human Genetics 8(2).
- Botha-Scheepers SA, Kroon HM, Slagboom E, Rosendaal FR, Breedveld FC & Klopppenburg M (2005), The natural history and determinants of lower extremity functioning over two years in osteoarthritis, Annals of the Rheumatic Diseases 64.
- Riyazi N, Botha-Scheepers SA, Houwing-Duistermaat JJ, Kroon HM, Rosendaal FR, Slagboom E, Breedveld FC & Kloppenburg M (2005), Why is there a discrepancy between disease and disability in osteoarthritis in the hands?, Annals of the Rheumatic Diseases 64.
- Wesoly J, Toes REM, Slagboom PE & Huizinga TWJ (2005), RUNX1 intronic SNP is not associated with rheumatoid arthritis susceptibility in Dutch Caucasians, Rheumatology 44(9).
- Mooijaart, S.P.; Brandt, B.W.; Baldal, E.A.; Pijpe, J.; Kuningas, M.; Beekman, M.; Zwaan, B.J.; Slagboom, P.E.; Westendorp, R.G.J. & Heemst, D. van (2005), C-elegans DAF-12, nuclear hormone receptors and human longevity and disease at old age, Ageing Research Reviews 4(3).
- Heijmans BT, Beekman M, Putter H, Lakenberg N, van der Wijk HJ, Whitfield JB, Posthuma D, Pedersen NL, Martin NG, Boomsma DI & Slagboom PE (2005), Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions, European Journal of Human Genetics 13(10).
- Botha-Scheepers SA, Watt I, Rosendaal FR, Breedveld FC, Slagboom E & Kloppenburg M (2005), Familial aggregation of radiological progression in siblings with symptomatic osteoarthritis at multiple sites: The GARP study, Arthritis and Rheumatism 52(9).
- Slof-Op 't Landt MCT, van Furth EF, Meulenbelt I, Slagboom RE, Bartels M, Boomsma DI & Bulik CM (2005), Eating disorders: From twin studies to candidate genes and beyond, Twin Research and Human Genetics 8(5).
- Posthuma D, Gosso F, Luciano M, de Geus EJC, Wright MJ, Montgomery GW, van Belzen M, Heutink P, Slagboom PE, Boomsma DI & Martin NG (2005), Gene finding for intelligence, Behavior Genetics 35(6): 817-818.
- Boomsma DI, Beem AL, Willemsen G, Hottenga JJ, de Geus EJC, Middeldor CM, Sullivan P, Suchiman E, Lakenberg N & Slagboom PE (2005), Genetic association tests of RGS genes on chromosome 1q for depression and correlated traits in the Netherlands Twin-family Study of Anxious Depression (NETSAD), Behavior Genetics 35(6): 794-795.
- Vink JM, Willemsen G, Posthuma D, Slagboom PE, Chen X, Neale M, Kendler K & Boonasma DL (2005), Genetics of smoking and nicotine dependence, Nicotine and Tobacco Research 7(4): 655-656.
- Monraats PS, de Vries FR, Slagboom EP, Zwinderman AH, de Maat MP, Agema WR, Hart LMT, de Winter R, Doevendans PA, Waltenberger J, Frants RR, van der Laarse A, Vandewall E & Jukema JW (2005), Inflammation and apoptosis genes and the risk of restenosis after percutaneous coronary intervention, Circulation 112(17): U57-U57.
- Monraats PS, Sewgobind VD, de Vries FR, Zwinderman AH, de Maat MP, Agema WR, Slagboom EP, Doevendans PA, de Winter R, Tio R, Waltenberger J, Frants RR, van der Laarse A, Vandewall E & Jukema JW (2005), MMP9, an important mediator of vascular remodelling, and risk of restenosis after percutaneous coronary intervention, Circulation 112(17): U166-U166.
- Riyazi N, Rosendaal FR, Slagboom E, Breedveld FC & Kloppenburg M (2005), Risk factors in familial osteoarthritis. The GARP Sibling Study, Annals of the Rheumatic Diseases 64: 67-67.
- Legraverand MPH, Pickering E, Redifer P, Totterman S, Tamez J, Slagboom E, Kornaat P, Riyazi N, Sheepers S & Kloppenburg M (2005), The prevalence of bone marrow edema in sibling pairs with familial osteoarthritis at multiple sites. The GARP study., Arthritis and Rheumatism 52(9): S69-S70.
- Leroi AM, Bartke A, De Benedictis G, Franceschi C, Gartner A, Gonos ES, Fedei ME, Kivisild T, Lee S, Kartaf-Ozer N, Schumacher M, Sikora E, Slagboom E, Tatar M, Yashin AI, Vijg J & Zwaan B (2005), What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? (vol 126, pg 421, 2005), Mechanisms of Ageing and Development 126(8): 906-906.
- Riyazi N, Slagboom E, de Craen AJ, Meulenbelt I, Houwing-Duistermaat JJ, Kroon HM, van Schaardenburg D, Rosendaal FR, Breedveld FC, Huizinga TW & Kloppenburg M (2005), Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation., Arthritis and Rheumatism 52(5): 1443-50.
- Mooijaart SP, Brandt BW, Baldal EA, Pijpe J, Kuningas M, Beekman M, Zwaan BJ, Slagboom PE, Westendorp RG & van Heemst D (2005), C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age., Ageing Research Reviews 4(3): 351-71.
- Brandt BW, Zwaan BJ, Beekman M, Westendorp RG & Slagboom PE (2005), Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?, BioEssays 27(3): 339-46.
- de Geus EJC, Posthuma D, Kupper N, van den Berg M, Willemsen G, Beem AL, Slagboom PE & Boomsma DI (2005), A whole-genome scan for 24-hour respiration rate: A major locus at 10q26 influences respiration during sleep, American Journal of Human Genetics 76(1).
- Heemst, D. van; Mooijaart, S.P.; Beekman, M.; Schreuder, J.; Craen, A.J.M. de; Brandt, B.W.; Slagboom, P.E.; Westendorp, R.G.J. & Long Life study grp (2005), Variation in the human TP53 gene affects old age survival and cancer mortality, Experimental Gerontology 40(1-2).
- Meulenbelt I, Slagboom PE & van Duijn CM (2005), Accuracy of haplotype association studies is enhanced by increasing number of polymorphic loci examined: comment on the article by Meulenbelt et al - Reply, Arthritis and Rheumatism 52(2).
- Leroi AM, Bartke A, De Benedictis G, Franceschi C, Gartner A, Gonos E, Feder ME, Kivisild T, Lee S, Kartal-Ozer N, Schumacher M, Sikora E, Slagboom E, Tatar M, Yashin AI, Vijg J & Zwaan B (2005), What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?, Mechanisms of Ageing and Development 126(3).
- Riyazi N, Meulenbelt I, Kroon HM, Ronday KH, le Graverand MPH, Rosendaal FR, Breedveld FC, Slagboom PE & Kloppenburg M (2005), Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study, Annals of the Rheumatic Diseases 64(3).
- Heemst, D. van; Beekman, M.; Mooijaart, S.P.; Heijmans, B.T.; Brandt, B.W.; Zwaan, B.J.; Slagboom, P.E. & Westendorp, R.G.J. (2005), Reduced insulin/IGF-1 signalling and human longevity, Aging Cell 4(2).
- Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, Pols HA, van Duijn CM & Slagboom PE (2005), Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites, Arthritis and Rheumatism 52(4).
- Alizadeh BZ, Njajou OT, Bijkerk C, Meulenbelt I, De Wildt SC, Hofman A, Pols HAP, Slagboom PE & van Duijn CM (2005), Evidence for a role of the genomic region of the gene encoding for the alpha 1 chain of type IX collagen (COL9A1) in hip osteoarthritis - A population-based study, Arthritis and Rheumatism 52(5).
- Riyazi N, Slagboom E, de Craen AJM, Meulenbelt I, Houwing-Duistermaat JJ, Kroon HM, van Schaardenburg D, Rosendaal FR, Breedveld FC, Huizinga TWJ & Kloppenburg M (2005), Association of the risk of osteoarthritis with high innate production of interleukin-1 beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation, Arthritis and Rheumatism 52(5).
- Posthuma D, Luciano M, de Geus EJC, Wright MJ, Slagboom PE, Montgomery GW, Boomsma DI & Martin NG (2005), A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p, American Journal of Human Genetics 77(2).
- Meulenbelt I, Kloppenburg M, Min JL, Kroon HM, Houwing-Duistermaat JJ, Le Graverand MH, De Groot J & Slagboom E (2005), UCTX-II levels are influenced by radiographic osteoarthritis (OA) in hip, knee, hand, and facet joints in sibling pairs with familial OA at multiple sites. The GARP study, Annals of the Rheumatic Diseases 64.
- Brandt BW, Zwaan BJ, Beekman M, Westendorp RGJ & Slagboom PE (2005), Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?, BioEssays 27(3).
- Willemsen G, Boomsma DI, Beem AL, Vink JM, Slagboom PE & Posthuma D (2004), QTLs for height: results of a full genome scan in Dutch sibling pairs, European Journal of Human Genetics 12(10).
- Alizadeh BZ, Njajou OT, Hazes JMW, Hofman A, Slagboom PE, Pols HAP & van Duijn CM (2004), The H63D mutation in the HFE gene predisposes to arthralgia, chondrocalcinosis, and osteoarthritis., Arthritis and Rheumatism 50(9).
- Meulenbelt I, Kloppenburg G, Min J, Pickering E, Le Graverand MPH, Groot J & Slagboom PE (2004), Cross sectional evaluation of biochemical markers of bone and cartilage metabolism in sibling pairs with familial OA at multiple sites. The GARP study, Osteoarthritis and Cartilage 12: S92-S93.
- Meulenbelt I, Min J, Kloppenburg M, Van Duijn CM & Slagboom E (2004), Genome wide scan in early onset generalized OA; Mutation analysis of a candidate gene, Annals of the Rheumatic Diseases 63: 120-120.
- Min J, Meulenbelt I, Kloppenburg M, Van Duijn CM & Slagboom E (2004), Genome wide scan in early onset generalized OA; Mutation and association analysis of candidate genes within the region of linkage, Annals of the Rheumatic Diseases 63: 120-120.
- Riyazi N, Rosendaal FR, Slagboom E, Breedveld FC & Kloppenburg M (2004), Risk factors in familial osteoarthritis. The GARP sibling study, Osteoarthritis and Cartilage 12: S112-S112.
- Alizadeh BZ, Njajou OT, Hazes JMW, Hofman A, Slagboom PE, Pols HAR & van Duijn CM (2004), The H63D mutation in the HFE gene predisposes to arthralgia, chondrocalcinosis, and osteoarthritis, Annals of the Rheumatic Diseases 63: 71-71.
- Mooijaart, S.P.; Heemst, D. van; Schreuder, J.; Gerwen, S. van; Beekman, M.; Brandt, B.W.; Slagboom, P.E.; Westendorp, R.G.J. & Long Life Study Grp (2004), Variation in the SHC1 gene and longevity in humans, Experimental Gerontology 39(2).
- Meulenbelt I, Seymour AB, Nieuwland M, Huizinga TWJ, van Duijn CM & Slagboom PE (2004), Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip, Arthritis and Rheumatism 50(4).
- Beekman M, Posthuma D, Heijmans BT, Lakenberg N, Suchiman HED, Snieder H, de Knijff P, Frants RR, van Ommen GJB, Kluft C, Vogler GP, Slagboom PE & Boomsma DI (2004), Combined association and linkage analysis applied to the APOE locus, Genetic Epidemiology 26(4).
- Heijmans BT, Beem AL, Willemsen G, Posthuma D, Slagboom PE & Boomsma DI (2004), Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families, Twin Research 7(2).
- Vink JM, Beem AL, Posthuma D, Neale MC, Willemsen G, Kendler KS, Slagboom PE & Boomsma DI (2004), Linkage analysis of smoking initiation and quantity in Dutch sibling pairs, Pharmacogenomics Journal 4(4).
- Botha-Scheepers SA, Riyazi N, Kroon HM, Slagboom E, Meulebelt I, Rosendaal FR, Breedveld FC & Kloppenburg M (2004), Pain and disability in the lower extremities in patients with osteoarthritis (OA) at multiple sites are associated with lumbar spine OA, the number of oa joints, range of motion and psychological factors, Annals of the Rheumatic Diseases 63.
- Riyazi N, Huizinga TJ, de Craen AR, Meulenbelt I, Kroon HM, Rosendaal R, Breedveld FC, Slagboom E & Kloppenburg M (2004), Identification of three new genetically determined risk factors for osteoarthritis (OA): High levels of interleukin (IL)-1 beta and IL-receptor antagonist (IL-1Ra) and low IL-10 production, Annals of the Rheumatic Diseases 63.
- Riyazi N, Hulzinga TWJ, De Craen AJM, Meulenbelt I, Kroon HM, Rosendaal FR, Breedveld FC, Slagboom E & Kloppenburg M (2004), Identification of three new genetically determined risk factors for osteoarthritis (OA): High levels of interleukin (IL)-1beta and IL-receptor antagonist (IL-1Ra) and low IL-10 production, Annals of the Rheumatic Diseases 63.
- Zhai G, Rivadeneira F, Houwing-Duistermat JJ, Meulenbelt I, Bijkerk C, Hofman A, van Meurs JBJ, Uitterlinden AG, Pols HAP, Slagboom PE & van Duijn CM (2004), Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha 1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study, Annals of the Rheumatic Diseases 63(5).
- Riyazi N, Meulenbelt I, Kroon HM, le Graverand MPH, Woodworth T, Rosendaal FR, Breedveld FC, Slagboom PE & Kloppenburg M (2003), Evidence for familial aggregation of hip, hand and spine osteoarthritis (OA) in siblings with clinical and radiological OA. The GARP study., Arthritis and Rheumatism 48(9).
- Houwing-Duistermaat JJ, Bijkerk C, Hsu L, Stijnen T, Slagboom EP & van Duijn CM (2003), A unified approach to modelling linkage to quantitative and qualitative traits, Annals of Human Genetics 67.
- Beekman M, Heijmans BT, Martin NG, Whitfield JB, Pedersen NL, DeFaire U, Snieder H, Lakenberg N, Knijff PC, Frants RR, van Ommen GJB, Kluft C, Vogler GR, Slagboom RE & Boomsma DI (2003), Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels, Twin Research 6(4).
- Heijmans BT, Boer JMA, Suchiman HED, Cornelisse CJ, Westendorp RGJ, Kromhout D, Feskens EJM & Slagboom PE (2003), A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer, Cancer Research 63(6).
- Beekman M, Heijmans BT, Martin NG, Whitfield JB, Pedersen NL, DeFaire U, Snieder H, Lakenberg N, Eka H, Suchiman D, de Knijff P, Frants RR, van Ommen GJB, Kluft C, Vogler GP, Boomsma DI & Slagboom PE (2003), Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population, European Journal of Human Genetics 11(11).
- Heijmans BT, Beekman M, Martin NG, Whitfield JB, Pedersen NI, DeFaire U, Snieder H, Lakenberg N, de Knijff P, Frants RR, van Ommen GJE, Kluft C, Vogler GP, Slagboom PE & Boomsma DI (2002), No evidence for a locus influencing Lp(a) levels cn chromosome, American Journal of Human Genetics 71(4): 454-454.
- van Aken MO, de Craen AJM, Gussekloo J, Moghaddam PH, Vandenbroucke JP, Heijmans BT, Slagboom PE & Westendorp RGJ (2002), No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus Study, European Journal of Clinical Investigation 32(10).
- Slagboom PE & Meulenbelt I (2002), Organisation of the human genome and our tools for identifying disease genes, Biological Psychology 61(1-2).
- Heijmans BT, Westendorp RGJ, Droog S, Kluft C, Knook D & Slagboom PE (2002), Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort, Genes and Immunity 3(4).
- Beekman M, Heijmans BT, Martin NG, Pedersen NL, Whitfield JB, DeFaire U, van Baal GCM, Snieder H, Vogler GP, Slagboom PE & Boomsma DI (2002), Heritabilities of apolipoprotein and lipid levels in three countries, Twin Research 5(2).
- Heijmans BT, Slagboom PE, Gussekloo J, Droog S, Lagaay AM, Kluft C, Knook DL & Westendorp RGJ (2002), Association of APOE epsilon 2/epsilon 3/epsilon 4 and promoter gene variants with dementia but not cardiovascular mortality in old age, American Journal of Medical Genetics 107(3).
- Meulenbelt I, Seymour A, Nieuwland M, Bijkerk C, Gabel CA, Huizinga T, van Duijn CM & Slagboom PE (2002), Interleukin-1 polymorphism significantly associated with increased risk for hip osteoarthritis in females., American Journal of Human Genetics 71(4): 347-347.
- Heijmans BT, Beekman M, Lakenberg N, Suchiman HED, Vogler GP, DeFaire U, Whitfield JB, de Knijff P, Kluft C, van Ommen GJB, Frants RR, Pedersen NL, Martin NG, Boomsma DI & Slagboom PE (2001), Genome scan for cardiovascular risk factors in three populations., American Journal of Human Genetics 69(4): 502-502.
- Beekman M, Heijmans BT, Lakenberg N, Suchiman E, Vogler GP, Martin NG, Whitfield JB, Pedersen NL, Kluft C, van Ommen GJB, Frants RR, de Knijff P, Slagboom E & Boomsma DI (2001), Genome scan for quantitative traits involved in cardiovascular disease in three independent populations., Behavior Genetics 31(5): 447-447.
- Beekman M, Lakenburg N, Cherny SS, De Knijff P, Kluft CC, Van Ommen GJB, Vogler GP, Frants RR, Boomsma DI & Slagboom PE (2001), A powerful and rapid approach to human genome scanning using small quantities of genomic DNA, Genetics Research 77(2).
- Feskens EJM, Heijmans BT, Slagboom PE & Kromhout D (2001), Insulin gene VNTR associated with type 2 diabetes: Interactions with age, body fatness and height, Diabetologia 44: A87-A87.
- Duffy D, Montgomery G, Treloar S, Birley A, Kirk K, Boomsma D, Beem L, de Geus E, Slagboom E, Knighton J, Reed P & Martin N (2001), IBD sharing around the PPARG locus is not increased in dizygotic twins or their mothers, Nature Genetics 28(4).
- Meulenbelt I, Slagboom PE & van Duijn C (2000), Analysis of the association of the matrillin-1 gene (CRTM) with osteoarthritis: comment on the article by Meulenbelt et al - Reply.
- Heijmans BT, Westendorp RGJ, Lagaay AM, Knook DL, Kluft C & Slagboom PE (2000), Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects.
- Slagboom PE, Heijmans BT, Beekman M, Westendorp RGJ & Meulenbelt I (2000), Genetics of human aging - The search for genes contributing to human longevity and diseases of the old.
- Heijmans BT, Westendorp RGJ & Slagboom PE (2000), Common gene variants, mortality and extreme longevity in humans, Experimental Gerontology 35(6-7).
- van Meurs JBJ, Arp PP, Fang Y, Slagboom PE, Meulenbelt I, van Leeuwen JPTM, Pols HAP & Uitterlinden AG (2000), Detection of sequence variability of the collagen type II alpha 1 3 ' variable number of tandem repeat, ELECTROPHORESIS 21(17).
- Meulenbelt I, Bijkerk C, Houwing-Duistermaat JJ, Breedveld FC, van Duijn CM & Slagboom PE (1999), Genetic studies on osteoarthritis., American Journal of Human Genetics 65(4): A435-A435.
- Bijkerk C, Houwing-Duistermaat JJ, Valkenburg HA, Meulenbelt I, Hofman A, Breedveld FC, Pols HAP, van Duijn CM & Slagboom PE (1999), Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine, Arthritis and Rheumatism 42(8): 1729-1735.
- Slagboom PE, Bijkerk C, Houwing-Duistermaat JJ, Valkenburg HA, Meulenbelt I, Hofman A, Breedveld FC, Pols HAP & van Duijn CM (1999), Heritability and candidate gene studies in Osteoarthritis, Zeitschrift f�r Gerontologie und Geriatrie 32(2): 127-127.
- Gussekloo J, Heijmans BT, Lagaay AM, Slagboom PE, Knook DL & Westendorp RGJ (1999), A common Methylenetetrahydrofolate Reductase polymorphism and cognitive decline in the oldest old., Zeitschrift f�r Gerontologie und Geriatrie 32(2): 120-120.
- Heijmans BT, Westendorp RGJ, Knook DL, Kluft C & Slagboom PE (1999), Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: Risk of mortality and fatal cardiovascular disease in an elderly population-based cohort, Journal of the American College of Cardiology 34(4): 1176-1183.
- Beekman M, Boomsma DI, De Knijff P, Vogler GP, Kluft CC, Van Ommen GJB, Frants RR & Slagboom PE (1999), Genome scan for quantitative traits involved in cardiovascular disease., American Journal of Human Genetics 65(4): A243-A243.
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