Thomas Ottenhoff
Professor Emeritus Immunology, in particular the immunity against mycobacteria
- Name
- Prof.dr. T.H.M. Ottenhoff
- t.h.m.ottenhoff@lumc.nl
- ORCID iD
- 0000-0003-3706-3403
Professor Ottenhof is full Professor in Immunology, in particular the immunology and Immunogenetics of mycobacterial infectious diseases. He is also Head Laboratory of the Dept. of Infectious Diseases and Head of the Group Immunology and Immunogenetics of Bacterial Infectious Diseases.
More information about Thomas Ottenhoff
Professor Ottenhof is full Professor in Immunology, in particular the immunology and Immunogenetics of mycobacterial infectious diseases. He is also Head Laboratory of the Dept. of Infectious Diseases and Head of the Group Immunology and Immunogenetics of Bacterial Infectious Diseases.
Brief research profile and mission statement
My mission is to dissect immunological and host-genetic mechanisms of protective and pathologic immunity to mycobacterial infections, in order to design more effective intervention strategies, including novel vaccination strategies, innovative diagnostics and anti-microbial treatments.
Tuberculosis
Tuberculosis research is a major theme in my research programs. Its TB research is fundamental, preclinical, translational as well as clinical in nature and includes partly humanized animal models of TB. Research efforts aim to develop better vaccines, as well as diagnostic, immunologic, transcriptomic and metabolic “biomarker signatures”. This work has led to a number of first-in-man clinical studies with new, molecularly defined synthetic TB vaccines. Systems biology, chemical genetics, transcriptomics, metabolomics and immunomics approaches are used to identify key cellular signalling pathways in host defense to intracellular pathogens in general, and M. tuberculosis and Salmonellae in particular. Correlates of protection and prospective correlates of risk of developing TB are being identified. Moreover, there is strong interest in co-infections (Helminth-infections; HIV) and co-morbidities including type-2 diabetes, a major TB-risk factor. Using technologies developed in the TB research program, recent work also enabled identification of biomarkers of Ebola-vaccine induced human responses. Extensive international collaborative networks have been established, which include leading partners from EU, US and TB endemic areas/countries (SA, Gambia, Gabon, Ethiopia, Indonesia, Brazil, China, etc.). The group has a strong international reputation, and an extensive portfolio of external competitive projects.
Some contributions
We have established an internationally esteemed research programme in the field of human immunology, cell biology and immunogenetics of mycobacterial infectious diseases. Amongst some of our scientific contributions, we discovered the first specific antigens for mycobacterium reactive T-cells in humans, were involved in identifying the first Thelper-1 cells in humans, discovered a new human immunodeficiency due to genetic mutations in the receptor for interleukin-12, cloned the first monoclonal T-regulatory cells in humans, have been involved in many human genetic studies that identified, with excellent collaborators, multiple new genetic variants impacting on risk of tuberculosis and leprosy, together with prof. Jacques Neefjes identified a new human PKB/Akt1 controlled signaling pathway that is manipulated by Salmonella and Mtb to inhibit phagosomal-lysosomal fusion, identified receptor tyrosine kinasese to be new targets for host directed therapy in TB (Nat Comm, in press), and executed several clinical phase I/IIa trials testing safety and long-term immunogenicity of new TB subunit vaccines. Our scientific mission is to dissect immunological and host-genetic mechanisms of protective and pathologic immunity to mycobacterial infections and related infectious diseases, in order to design more effective intervention strategies. One focus is on the role of T cell subsets (T-helper, T-regulatory), macrophage subsets, intracellular signaling networks, cellular function and systems biology. A second, more translation-oriented focus is on Mtb antigen discovery, TB vaccine design, novel TB diagnostic test development and TB biomarker discovery.
I have been a member of the advisory board of a LUMC Biotech spin off company, ISA Pharmaceuticals.
Training of postdocs and PhD students
I have had the privilege of working with many excellent students and researchers in the lab over the years. I have supervised 18 PhD students theses, have been and am involved as adviser in others. I have supervised >20 postdoctoral fellows.
Training and Degrees
- 1982 MD degree, Leiden University Medical Center (LUMC)
- 1986 PhD (cum laude), Leiden University (“HLA class II immune response genes in leprosy”
Academic appointments
- 1982-1986 PhD training and Clinical Blood Bank Consultant in Transfusion Medicine at LUMC
- 1986-1988 Senior Scientist at Armauer Hansen Research Institute, Addis Ababa, Ethiopia
- 1989-1993 Honorary Huygens Fellowship Award (Netherlands Organization for Scientific Research); based at LUMC
- 1991-1993 Visiting Professor at the Cell Biology and Metabolism Branch, NICHD, NIH, Bethesda, MD
- 1994 Assistant Professor at LUMC
- 1998 Associate Professor at LUMC
- 2001 Full Professor at LUMC and Leiden University (Dept. Infectious Diseases, Center)
- 2008 Visiting Professor at Stanford University (Dept Microbiology and Immunology, prof. Gary Schoolnik, Stanford University School of Medicine), Palo Alto, CA.
Academic Honors and Indicators of Esteem
General
- Several personal awards (Eijkman Medal, Swierenga Medal, American Acad. Microbiology distinction).
- Regular presentations as invited speaker on international, national congresses and public meetings.
- Member of many large projects’ Steering Committees
- Participation in advisory boards (monitoring- and evaluation committees)
- Member Senior Management Team TBVI (since 2015)
Specific
- 1989-1993 C. and C. Huygens Fellowship Award (Netherlands Organization for Scientific Research)
- 1996 C.J. Kok Award, Leiden University
- 1999-2005 Member various Review Panels of Deutsche Forschungsgemeinschaft on Vaccine Projects
- 2002-2008 Member of the NWO-VENI Research Committee (Netherlands Organisation for Scientific Research, Innovation Research program) for promising young scientists
- 2003-2013 Member of the "Gezondheidsraad" (Netherlands Government Council of Health), Section Infection and Immunity.
- 2003-present Member Scientific Advisory Panel TB Vaccines for the World 2004, 2006, 2008, 2012
- 2003-2006 Member Editorial Board Infection and Immunity
- 2004-present Member Editorial Board Current Immunology Reviews.
- 2004 Guest Editor Current Opin. Immunol. (with Michael Bevan) on "Host Pathogen interactions".
- 2005 Guest Editor Microb. Infect. Issue on "Host Genetics and Mycobacterial Infectious Diseases"
- 2006-2010 Member of the "Gezondheidsraad" (Netherlands Government Council of Health), Expert Advisory Committee on BCG Vaccination.
- 2006-present Member Review Panel Deutsche Forschungsgemeinschaft on “Initiative for new German Centers of Excellence and Master Schools”.
- 2007-present Member Editorial Board The Open Microbiology Journal
- 2007-present Member of Stop TB Core Working Group on New Vaccines- Task Force Laboratory Assays
- 2007-2010 Member Working Group on Use of Infected Target Cells for Assessing Protective Efficacy of new TB Vaccines. Organiser of the International Workshop/Symposium on Discovery of New Mtb Antigens Expressed on Infected Cells (WHO, Geneva).
- 2008 Co-founding Member Tuberculosis Vaccine Initiative (see www.tbvi.eu)
- 2008, 2012 Advisor to the Gates Foundation on TB Biomarkers
- 2008-2009 Member of the European Academies Science Advisory Council (EASAC)(on behalf of the Dutch Government), Working Group on Drug-resistant Tuberculosis
- 2008 Adviser to WHO and EC at "TDR-EC joint expert consultation meeting to evaluate the role of bio-surrogate markers in the management of HIV-infected and -uninfected TB patients
- 2010 Eurolife Distinguished Faculty Speaker, Trinity College, Dublin, Ireland
- 2011-present Member of the “Decade for Vaccines” R&D Working Group
- 2012-present Member Editorial Board American Journal of Clinical and Experimental Immunology
- 2013 Eijkman medal awarded
- 2012 Member of the Biomarker Core Working group, Aeras Foundation, Rockville USA
- 2014 Elected Fellow American Academy of Microbiology (an honorific society of microbiologists who have distinguished themselves in research, education, clinical science, or administration).
- 2014 J Swierenga medal awarded
- 2011-2018 Elected member of ERC starting grant evaluation panel LS6 (Infection and Immunity)
- 2018 Adviser to WHO at TDR consultation on TB Vaccines development.
Professor Emeritus Immunology, in particular the immunity against mycobacteria
- Faculteit Geneeskunde
- Divisie 2
- Infectious Diseases
- Neustrup M.A., Ottenhoff T.H.M., Jiskoot W., Bouwstra J.A. & Maaden K. van der (2024), A Versatile, Low-Cost Modular Microfluidic System to Prepare Poly(Lactic-co-Glycolic Acid) Nanoparticles With Encapsulated Protein, Pharmaceutical Research : .
- Szachniewicz M.M., Meijgaarden K.E.V., Kavrik E., Jiskoot W., Bouwstra J.A., Haks M.C., Geluk A. & Ottenhoff T.H.M. (2024), Cationic pH-sensitive liposomes as tuberculosis subunit vaccine delivery systems: Effect of liposome composition on cellular innate immune responses, International Immunopharmacology 145: 113782.
- Voogd, L.; Wolfswinkel, M. van; Satti, I.; White, A.D.; Dijkman, K.; Gela, A.; Meijgaarden, K.E. van; Franken, K.L.M.C.; Marshall, J.L.; Ottenhoff, T.H.M.; Scriba, T.J.; Mcshane, H.; Sharpe, S.A.; Verreck, F.A.W. & Joosten, S.A. (2024), Mtb-specific HLA-E-restricted T cells are Induced during Mtb infection but not after BCG administration in non-human primates and humans, Vaccines 12(10).
- Biggelaar, R.H.G.A. van den; Walburg, K.V.; Eeden, S.J.F. van den; Doorn, C.L.R. van; Meiler, E.; Ries, A.S. de; Meijer, A.H.; Ottenhoff, T.H.M. & Saris, A. (2024), Identification of kinase modulators as host-directed therapeutics against intracellular methicillin-resistant Staphylococcus aureus, Frontiers in Cellular and Infection Microbiology 14.
- Martinez-Murillo, P.A.; Huttner, A.; Lemeille, S.; Medaglini, D.; Ottenhoff, T.H.M.; Harandi, A.M.; Didierlaurent, A.M.; Siegrist, C.A.; VEBCON; VSV-EBOVAC & VSV-EBOPLUS Consortia (2024), Refined innate plasma signature after rVSVΔG-ZEBOV-GP immunization is shared among adult cohorts in Europe and North America, Frontiers in Immunology 14.
- Alonso-Rodríguez, N.; Vianello, E.; Veen, S. van; Jenum, S.; Tonby, K.; Riessen, R. van; Lai, X.R.; Mortensen, R.; Ottenhoff, T.H.M. & Dyrhol-Riise, A.M. (2024), Whole blood RNA signatures in tuberculosis patients receiving H56:IC31 vaccine as adjunctive therapy, Frontiers in Immunology 15.
- Dirks, R.P.; Ordas, A.; Jong-Raadsen, S.; Brittijn, S.A.; Haks, M.C.; Henkel, C.V.; Oravcova, K.; Racz, P.I.; Tuinhof-Koelma, N.; Wiweger, M.I.K.N.; Gillespie, S.H.; Meijer, A.H.; Ottenhoff, T.H.M.; Jansen, H.J. & Spaink, H.P. (2024), The Human Pathogen Mycobacterium tuberculosis and the Fish Pathogen Mycobacterium marinum trigger a core set of late innate immune response genes in zebrafish larvae, Biology 13(9).
- Barclay, A.M.; Ninaber, D.K.; Limpens, R.W.A.L.; Walburg, K.; Bárcena, M.; Hiemstra, P.S.; Ottenhoff, T.H.M.; Does, A.M. van der & Joosten, S.A. (2024), Mycobacteria develop biofilms on airway epithelial cells and promote mucosal barrier disruption, iScience 27(11).
- Meijgaarden, K.E. van; Veen, S. van; Tsonaka, R.; Ruibal, P.; Roukens, A.H.E.; Arbous, S.M.; Manniën, J.; Cannegieter, S.C.; Ottenhoff, T.H.M.; Joosten, S.A.; BEAT-COVID Grp & COVID-19 LUMC Grp (2024), Longitudinal soluble marker profiles reveal strong association between cytokine storms resulting from macrophage activation and disease severity in COVID-19 disease, Scientific Reports 14(1).
- Biggelaar, R.H.G.A. van den; Walburg, K.V.; Eeden, S.J.F. van den; Doorn, C.L.R. van; Meiler, E.; Ries, A.S. de; Fusco, M.C.; Meijer, A.H.; Ottenhoff, T.H.M. & Saris, A. (2024), Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria, Scientific Reports 14(1).
- Kilinc, G.; Boland, R.; Heemskerk, M.T.; Spaink, H.P.; Haks, M.C.; Vaart, M. van der; Ottenhoff, T.H.M.; Meijer, A.H. & Saris, A. (2024), Host-directed therapy with amiodarone in preclinical models restricts mycobacterial infection and enhances autophagy, Microbiology Spectrum 12(8).
- Szachniewicz, M.M.; Neustrup, M.A.; Eeden, S.J.F. van den; Meijgaarden, K.E. van; Franken, K.L.M.C.; Veen, S. van; Koning, R.I.; Limpens, R.W.A.L.; Geluk, A.; Bouwstra, J.A. & Ottenhoff, T.H.M. (2024), Evaluation of PLGA, lipid-PLGA hybrid nanoparticles, and cationic pH-sensitive liposomes as tuberculosis vaccine delivery systems in a Mycobacterium tuberculosis challenge mouse model , International Journal of Pharmaceutics 666.
- Bakker, A.T.; Kotsogianni, I.; Avalos, M.; Punt, J.M.; Liu, B.; Piermarini, D.; Gagestein, B.; Slingerland, C.J.; Zhang, L.; Willemse, J.J.; Ghimire, L.B.; Berg, R.J.H.B.N. van den; Janssen, A.P.A.; Ottenhoff, T.H.M.; Boeckel, C.A.A. van; Wezel, G.P. van; Ghilarov, D.; Martin, N.I. & Stelt, M. van der (2024), Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria, NATURE CHEMISTRY 16(9).
- Voogd, L.; Drittij, A.M.H.F.; Dingenouts, C.K.E.; Franken, K.L.M.C.; Unen, V. van; Meijgaarden, K.E. van; Ruibal, P.; Hagedoorn, R.S.; Leitner, J.A.; Steinberger, P.; Heemskerk, M.H.M.; Davis, M.M.; Scriba, T.J.; Ottenhoff, T.H.M. & Joosten, S.A. (2024), MtbHLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire, iScience 27(3).
- Szachniewicz, M.M.; Eeden, S.J.F. van den; Meijgaarden, K.E. van; Franken, K.L.M.C.; Veen, S. van; Geluk, A.; Bouwstra, J.A. & Ottenhoff, T.H.M. (2024), Cationic pH-sensitive liposome-based subunit tuberculosis vaccine induces protection in mice challenged with Mycobacterium tuberculosis, European Journal of Pharmaceutics and Biopharmaceutics 203.
- Davies, L.R.L.; Wang, C.Q.; Steigler, P.; Bowman, K.A.; Fischinger, S.; Hatherill, M.; Fisher, M.; Mbandi, S.K.; Rodo, M.; Ottenhoff, T.H.M.; Dockrell, H.M.; Sutherland, J.S.; Mayanja-Kizza, H.; Boom, W.H.; Walzl, G.; Kaufmann, S.H.E.; Nemes, E.; Scriba, T.J.; Lauffenburger, D.; Alter, G. & Fortune, S.M. (2024), Age and sex influence antibody profiles associated with tuberculosis progression, Nature Microbiology.
- Meijgaarden, K.E. van; Li, W.C.; Moorlag, S.J.C.F.M.; Koeken, V.A.C.M.; Koenen, H.J.P.M.; Joosten, L.A.B.; Vyakarnam, A.; Ahmed, A.; Rakshit, S.; Adiga, V.; Ottenhoff, T.H.M.; Li, Y.; Netea, M.G. & Joosten, S.A. (2024), BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination, Nature Communications 15(1).
- Niewold, P.; Dijkstra, D.J.; Cai, Y.; Goletti, D.; Palmieri, F.; Meijgaarden, K.E. van; Verreck, F.A.W.; Akkerman, O.W.; Hofland, R.W.; Delemarre, E.M.; Nierkens, S.; Verheul, M.K.; Pollard, A.J.; Dissel, J.T. van; Ottenhoff, T.H.M.; Trouw, L.A. & Joosten, S.A. (2023), Identification of circulating monocytes as producers of tuberculosis disease biomarker C1q, Scientific Reports 13(1).
- Musvosvi, M.; Huang, H.; Wang, C.L.; Xia, Q.; Rozot, V.; Krishnan, A.; Acs, P.; Cheruku, A.; Obermoser, G.; Leslie, A.; Behar, S.M.; Hanekom, W.A.; Bilek, N.; Fisher, M.; Kaufmann, S.H.E.; Walzl, G.; Hatherill, M.; Davis, M.M.; Scriba, T.J.; Adolescent Cohort Study Team & GC6-74 Consortium (2023), T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection, Nature Medicine 29(1): 258-+.
- Tang, H.Q.; Ali, A.; Abdelazem, E.; Ottenhoff, T.H.M.; Heeren, R.M.A. & Mashaghi, A. (2023), Random forest and live single-cell metabolomics reveal metabolic profiles of human macrophages upon polarization, Biotechnology and Bioengineering 120(8).
- Barclay, A.M.; Ninaber, D.K.; Veen, S. van; Hiemstra, P.S.; Ottenhoff, T.H.M.; Does, A.M. van der & Joosten, S.A. (2023), Airway epithelial cells mount an early response to mycobacterial infection, Frontiers in Cellular and Infection Microbiology 13.
- Carvalho, P.C.G.D.; Hirata, T.D.C.; Alves, L.Y.M.; Moscardini, I.F.; Nascimento, A.P.B. do; Costa-Martins, A.G.; Sorgi, S.; Harandi, A.M.; Ferreira, D.M.; Vianello, E.; Haks, M.C.; Ottenhoff, T.H.M.; Santoro, F.; Martinez-Murillo, P.; Huttner, A.; Siegrist, C.A.; Medaglini, D.; Nakaya, H.I.; VSV-EBOVAC Consortia & VSV-EBOPLUS Consortia (2023), Baseline gene signatures of reactogenicity to Ebola vaccination, Frontiers in Immunology 14.
- Ahmed, A.; Tripathi, H.; Meijgaarden, K.E.V.; Kumar, N.C.; Adiga, V.; Rakshit, S.; Parthiban, C.; Eveline, J.S.; D'Souza, G.; Dias, M.; Ottenhoff, T.H.M.; Netea, M.G.; Joosten, S.A. & Vyakarnam, A. (2023), BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways, iScience 26(10).
- Nziza, N.; Cizmeci, D.; Davies, L.; Irvine, E.B.; Jung, W.Y.; Fenderson, B.A.; Kock, M. de; Hanekom, W.A.; Franken, K.L.M.C.; Day, C.L.; Ottenhoff, T.H.M. & Alter, G. (2023), Defining discriminatory antibody fingerprints in active and latent tuberculosis (vol 13, 856906, 2022), Frontiers in Immunology 14.
- Eckold, C.; Doorn, C.L.R. van; Ruslami, R.; Ronacher, K.; Riza, A.L.; Veen, S. van; Lee, J.S.; Kumar, V.; Kerry-Barnard, S.; Malherbe, S.T.; Kleynhans, L.; Stanley, K.; Joosten, S.A.; Critchley, J.A.; Hill, P.C.; Crevel, R. van; Wijmenga, C.; Haks, M.C.; Ioana, M.; Alisjahbana, B.; Walzl, G.; Ottenhoff, T.H.M.; Dockrell, H.M.; Vianello, E.; Cliff, J.M. & TANDEM Consortium (2023), Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity, Clinical and Translational Medicine 13(9).
- Tang, H.Q.; Abouleila, Y.; Saris, A.; Shimizu, Y.; Ottenhoff, T.H.M. & Mashaghi, A. (2023), Ebola virus-like particles reprogram cellular metabolism, Journal of Molecular Medicine 101(5): 557-568.
- Wolfswinkel, M. van; Meijgaarden, K.E. van; Ottenhoff, T.H.M.; Niewold, P. & Joosten, S.A. (2023), Extensive flow cytometric immunophenotyping of human PBMC incorporating detection of chemokine receptors, cytokines and tetramers, Cytometry Part A 103(7): 600-610.
- Afkhami, S.; D'Agostino, M.R.; Vaseghi-Shanjani, M.; Lepard, M.; Yang, J.X.; Lai, R.; Choi, M.W.Y.; Chacon, A.; Zganiacz, A.; Franken, K.L.M.C.; Ertl, H.C.; Ottenhoff, T.H.M.; Jeyanathan, M.; Gillgrass, A. & Xing, Z. (2023), Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice, npj Vaccines 8(1).
- Nziza, N.; Jung, W.Y.; Mendu, M.; Chen, T.A.; McNamara, R.P.; Fortune, S.M.; Franken, K.L.M.C.; Ottenhoff, T.H.M.; Bryson, B.; Ngonzi, J.; Bebell, L.M. & Alter, G. (2023), Maternal HIV infection drives altered placental Mtb-specific antibody transfer, Frontiers in Microbiology 14.
- Vianello, E.; Gonzalez-Dias, P.; Veen, S. van; Engele, C.G.; Quinten, E.; Monath, T.P.; Medaglini, D.; Santoro, F.; Huttner, A.; Dubey, S.; Eichberg, M.; Ndungu, F.M.; Kremsner, P.G.; Essone, P.N.; Agnandji, S.T.; Siegrist, C.A.; Nakaya, H.I.; Ottenhoff, T.H.M.; Haks, M.C.; VSV-EBOVAC Consortium & VSV-EBOPLUS Consortium (2022), Transcriptomic signatures induced by the Ebola virus vaccine rVSV Delta G-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study, The Lancet Microbe 3(2): E113-E123.
- Straat, M.E.; Martinez-Tellez, B.; Eyk, H.J. van; Bizino, M.B.; Veen, S. van; Vianello, E.; Stienstra, R.; Ottenhoff, T.H.M.; Lamb, H.J.; Smit, J.W.A.; Jazet, I.M.; Rensen, P.C.N. & Boon, M.R. (2022), Differences in inflammatory pathways between Dutch South Asians vs Dutch Europids with type 2 diabetes, The Journal of Clinical Endocrinology & Metabolism 108(4).
- Uzorka, J.W.; Bakker, J.A.; Meijgaarden, K.E. van; Leyten, E.M.S.; Delfos, N.M.; Hetem, D.J.; Kerremans, J.; Zwarts, M.; Cozijn, S.; Ottenhoff, T.H.M.; Joosten, S.A. & Arend, S.M. (2022), Biomarkers to identify Mycobacterium tuberculosis infection among borderline QuantiFERON results, European Respiratory Journal 60(2).
- Rakshit, S.; Adiga, V.; Ahmed, A.; Parthiban, C.; Kumar, N.C.; Dwarkanath, P.; Shivalingaiah, S.; Rao, S.S.; D'Souza, G.; Dias, M.; Maguire, T.J.A.; Doores, K.J.; Zoodsma, M.; Geckin, B.; Dasgupta, P.; Babji, S.; Meijgaarden, K.E. van; Joosten, S.J.; Ottenhoff, T.H.M.; Li, Y.; Netea, M.G.; Stuart, K.D.; Rosa, S.C. de; McElrath, M.J. & Vyakarnam, A. (2022), Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD (TM) vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults, Frontiers in Immunology 13.
- Ruibal, P.; Franken, K.L.M.C.; Meijgaarden, K.E.V.; Wolfswinkel, M. van; Derksen, I.; Scheeren, F.A.; Janssen, G.M.C.; Veelen, P.A. van; Sarfas, C.; White, A.D.; Sharpe, S.A.; Palmieri, F.; Petrone, L.; Goletti, D.; Abeel, T.; Ottenhoff, T.H.M. & Joosten, S.A. (2022), Identification of HLA-E binding Mycobacterium tuberculosis-derived epitopes through improved prediction models, The Journal of Immunology 209(8): 1555-1565.
- Boland, R.; Heemskerk, M.T.; Forn-Cuni, G.; Korbee, C.J.; Walburg, K.V.; Esselink, J.J.; Santos, C.C. dos; Waal, A.M. de; Hoeven, D.C.M. van der; Sar, E. van der; Ries, A.S. de; Xie, J.J.; Spaink, H.P.; Vaart, M. van der; Haks, M.C.; Meijer, A.H. & Ottenhoff, T.H.M. (2022), Repurposing tamoxifen as potential host-directed therapeutic for tuberculosis, mBio 14(1).
- Ruibal, P.; Derksen, I.; Wolfswinkel, M. van; Voogd, L.; Franken, K.L.M.C.; Hebieshy, A.F. el; Hall, T. van; Schoufour, T.A.W.; Wijdeven, R.H.; Ottenhoff, T.H.M.; Scheeren, F.A. & Joosten, S.A. (2022), Thermal-exchange HLA-E multimers reveal specificity in HLA-E and NKG2A/CD94 complex interactions, Immunology 168(3).
- Doorn, C.L.R. van; Eckold, C.; Ronacher, K.; Ruslami, R.; Veen, S. van; Lee, J.S.; Kumar, V.; Kerry-Barnard, S.; Malherbe, S.T.; Kleynhans, L.; Stanley, K.; Hill, P.C.; Joosten, S.A.; Crevel, R. van; Wijmenga, C.; Critchley, J.A.; Walzl, G.; Alisjahbana, B.; Haks, M.C.; Dockrell, H.M.; Ottenhoff, T.H.M.; Vianello, E.; Cliff, J.M. & TANDEM Consortium (2022), Transcriptional profiles predict treatment outcome in patients with tuberculosis and diabetes at diagnosis and at two weeks after initiation of anti-tuberculosis treatment, EBioMedicine 82.
- Eckold, C.; Doorn, C.L.R. van; Ruslami, R.; Ronacher, K.; Riza, A.L.; Veen, S. van; Lee, J.S.; Kumar, V.; Kerry-Barnard, S.; Malherbe, S.T.; Kleynhans, L.; Stanley, K.; Joosten, S.A.; Critchley, J.A.; Hill, P.C.; Crevel, R. van; Wijmenga, C.; Haks, M.C.; Ioana, M.; Alisjahbana, B.; Walzl, G.; Ottenhoff, T.H.M.; Dockrell, H.M.; Vianello, E.; Cliff, J.M. & TANDEM Consortium (2022), Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity.
- Bahrami, F.; Masoudzadeh, N.; Veen, S. van; Persson, J.; Lari, A.; Sarvnaz, H.; Taslimi, Y.; Ostensson, M.; Andersson, B.; Sharifi, I.; Goyonlo, V.M.; Ottenhoff, T.H.; Haks, M.C.; Harandi, A.M. & Rafati, S. (2022), Blood transcriptional profiles distinguish different clinical stages of cutaneous leishmaniasis in humans, Molecular Immunology 149: 165-173.
- Roukens, A.H.E.; Pothast, C.R.; Konig, M.; Huisman, W.; Dalebout, T.; Tak, T.; Azimi, S.; Kruize, Y.; Hagedoorn, R.S.; Zlei, M.; Staal, F.J.T.; Bie, F.J. de; Dongen, J.J.M. van; Arbous, S.M.; Zhang, J.L.H.; Verheij, M.; Prins, C.; Does, A.M. van der; Hiemstra, P.S.; Vries, J.J.C. de; Janse, J.J.; Roestenberg, M.; Myeni, S.K.; Kikkert, M.; Yazdanbakhsh, M.; Heemskerk, M.H.M.; Smits, H.H.; Jochems, S.P.; Collaboration BEAT-COVID Grp & Collaboration COVID-19 LUMC Grp (2022), Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8(+) T cell responses following COVID-19, Nature Immunology 23.
- Jacobs, R.; Awoniyi, D.O.; Baumann, R.; Stanley, K.; McAnda, S.; Kaempfer, S.; Malherbe, S.T.; Singh, M.; Walzl, G.; Chegou, N.N. & AE-TBC Consortium (2022), Concurrent evaluation of cytokines improves the accuracy of antibodies against Mycobacterium tuberculosis antigens in the diagnosis of active tuberculosis, Tuberculosis 133.
- Waal, A.M. de; Hiemstra, P.S.; Ottenhoff, T.H.M.; Joosten, S.A. & Does, A.M. van der (2022), Lung epithelial cells interact with immune cells and bacteria to shape the microenvironment in tuberculosis, Thorax 77.
- Vianello, E.; Gonzalez-Dias, P.; Veen, S. van; Engele, C.G.; Quinten, E.; Monath, T.P.; Medaglini, D.; Santoro, F.; Huttner, A.; Dubey, S.; Eichberg, M.; Ndungu, F.M.; Kremsner, P.G.; Essone, P.N.; Agnandji, S.T.; Siegrist, C.A.; Nakaya, H.I.; Ottenhoff, T.H.M.; Haks, M.C.; VSV-EBOVAC Consortium & VSV-EBOPLUS Consortium (2022), Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America, The Lancet Microbe 3(2): E113-E123.
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- Huang, W.; Qi, Y.J.; Diao, Y.J.; Yang, F.; Zha, X.D.; Ren, C.P.; Huang, D.K.; Franken, K.L.M.C.; Ottenhoff, T.H.M.; Wu, Q.S. & Shen, J.J. (2014), Use of Resuscitation-Promoting Factor Proteins Improves the Sensitivity of Culture-based Tuberculosis Testing in Special Samples, American Journal of Respiratory and Critical Care Medicine 189(5): 612-614.
- Geluk Annemieke, van Meijgaarden Krista E., Joosten Simone A., Commandeur Susanna & Ottenhoff Tom H. M. (2014), Innovative strategies to identify M. tuberculosis antigens and epitopes using genome-wide analyses, Frontiers in Immunology 5.
- Bobosha, K.; Fat, E.M.T.K.; Eeden, S.J.F. van den; Bekele, Y.; Ploeg-van Schip, J.J. van der; Dood, C.J. de; Dijkman, K.; Franken, K.L.M.C.; Wilson, L.; Aseffa, A.; Spencer, J.S.; Ottenhoff, T.H.M.; Corstjens, P.L.A.M. & Geluk, A. (2014), Field-Evaluation of a New Lateral Flow Assay for Detection of Cellular and Humoral Immunity against Mycobacterium leprae, PLoS Neglected Tropical Diseases 8(5).
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- Vaart, M. van der; Korbee, C.J.; Lamers, G.E.M.; Tengeler, A.C.; Hosseini, R.; Haks, M.C.; Ottenhoff, T.H.M.; Spaink, H.P. & Meijer, A.H. (2014), The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense, Cell Host and Microbe 15(6): 753-767.
- Commandeur, S.; Eeden, S.J.F. van den; Dijkman, K.; Clark, S.O.; Meijgaarden, K.E. van; Wilson, L.; Franken, K.L.M.C.; Williams, A.; Christensen, D.; Ottenhoff, T.H.M. & Geluk, A. (2014), The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4(+) T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs, Vaccine 32(29): 3580-3588.
- Ivanyi, J. & Ottenhoff, T.H.M. (2014), Significance of antigen and epitope specificity in tuberculosis, Frontiers in Immunology 5.
- Dissel, J.T. van; Joosten, S.A.; Hoff, S.T.; Soonawala, D.; Prins, C.; Hokey, D.A.; O'Dee, D.M.; Graves, A.; Thierry-Carstensen, B.; Andreasen, L.V.; Ruhwald, M.; Visser, A.W. de; Agger, E.M.; Ottenhoff, T.H.M.; Kromann, I. & Andersen, P. (2014), A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human, Vaccine 32(52): 7098-7107.
- Hur, Y.G.; Gorak-Stolinska, P.; Ben-Smith, A.; Lalor, M.K.; Chaguluka, S.; Dacombe, R.; Doherty, T.M.; Ottenhoff, T.H.; Dockrell, H.M. & Crampin, A.C. (2013), Combination of Cytokine Responses Indicative of Latent TB and Active TB in Malawian Adults, PLoS ONE 8(11).
- Sutherland, J.S.; Lalor, M.K.; Black, G.F.; Ambrose, L.R.; Loxton, A.G.; Chegou, N.N.; Kassa, D.; Mihret, A.; Howe, R.; Mayanja-Kizza, H.; Gomez, M.P.; Donkor, S.; Franken, K.; Hanekom, W.; Klein, M.R.; Parida, S.K.; Boom, W.H.; Thiel, B.A.; Crampin, A.C.; Ota, M.; Walzl, G.; Ottenhoff, T.H.M.; Dockrell, H.M.; Kaufmann, S.H.E. & GCGH Biomarkers TB Consortium (2013), Analysis of Host Responses to Mycobacterium tuberculosis Antigens in a Multi-Site Study of Subjects with Different TB and HIV Infection States in Sub-Saharan Africa, PLoS ONE 8(9).
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- Boer, M.C.; Meijgaarden, K.E. van; Bastid, J.; Ottenhoff, T.H.M. & Joosten, S.A. (2013), CD39 is involved in mediating suppression by Mycobacterium bovis BCG-activated human CD8+CD39+regulatory T cells, European Journal of Immunology 43(7): 1925-1932.
- Paus, R.A. de; Crevel, R. van; Beek, R. van; Sahiratmadja, E.; Alisjahbana, B.; Marzuki, S.; Rimmelzwaan, G.F.; Dissel, J.T. van; Ottenhoff, T.H.M. & Vosse, E. van de (2013), The influence of influenza virus infections on the development of tuberculosis.
- Boer, M.C.; Meijgaarden, K.E. van; Bastid, J.; Ottenhoff, T.H.M. & Joosten, S.A. (2013), CD39 is involved in mediating suppression by Mycobacterium bovis BCG-activated human CD8(+) CD39(+) regulatory T cells., European Journal of Immunology 43(7): 1925-32.
- Kaforou, M.; Wright, V.J.; Oni, T.; French, N.; Anderson, S.T.; Bangani, N.; Banwell, C.; Brent, A.J.; Crampin, A.C.; Dockrell, H.M.; Eley, B.; Heyderman, R.S.; Hibberd, M.L.; Kern, F.; Langford, P.R.; Ling, L.; Mendelson, M.; Ottenhoff, T.H.; Zgambo, F.; Wilkinson, R.J.; Coin, L.J. & Levin, M. (2013), Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study.
- Huang, W.; Qi, Y.J.; Ren, C.P.; Wen, H.; Franken, K.L.M.C.; Ottenhoff, T.H.M. & Shen, J.J. (2013), Interferon-γ responses to Mycobacterium tuberculosis Rpf proteins in contact investigation., Tuberculosis 93(6): 612-7.
- Laarhoven, A. van; Mandemakers, J.J.; Kleinnijenhuis, J.; Enaimi, M.; Lachmandas, E.; Joosten, L.A.B.; Ottenhoff, T.H.M.; Netea, M.G.; Soolingen, D. van & Crevel, R. van (2013), Low Induction of Proinflammatory Cytokines Parallels Evolutionary Success of Modern Strains within the Mycobacterium tuberculosis Beijing Genotype, Infection and Immunity 81(10): 3750-3756.
- Jackson-Sillah, D.; Cliff, J.M.; Mensah, G.I.; Dickson, E.; Sowah, S.; Tetteh, J.K.A.; Addo, K.K.; Ottenhoff, T.H.M.; Bothamley, G. & Dockrell, H.M. (2013), Recombinant ESAT-6-CFP10 Fusion Protein Induction of Th1/Th2 Cytokines and FoxP3 Expressing Treg Cells in Pulmonary TB, PLoS ONE 8(6).
- Legesse, M.; Ameni, G.; Medhin, G.; Mamo, G.; Franken, K.L.M.C.; Ottenhoff, T.H.M.; Bjune, G. & Abebe, F. (2013), IgA Response to ESAT-6/CFP-10 and Rv2031 Antigens Varies in Patients With Culture-Confirmed Pulmonary Tuberculosis, Healthy Mycobacterium tuberculosis-Infected and Non-Infected Individuals in a Tuberculosis Endemic Setting, Ethiopia, Scandinavian Journal of Immunology 78(3): 266-274.
- Joosten, S.A.; Fletcher, H.A. & Ottenhoff, T.H.M. (2013), A Helicopter Perspective on TB Biomarkers: Pathway and Process Based Analysis of Gene Expression Data Provides New Insight into TB Pathogenesis, PLoS ONE 8(9).
- Commandeur, S.; Meijgaarden, K.E. van; Prins, C.; Pichugin, A.V.; Dijkman, K.; Eeden, S.J.F. van den; Friggen, A.H.; Franken, K.L.M.C.; Dolganov, G.; Kramnik, I.; Schoolnik, G.K.; Oftung, F.; Korsvold, G.E.; Geluk, A. & Ottenhoff, T.H.M. (2013), An Unbiased Genome-Wide Mycobacterium tuberculosis Gene Expression Approach To Discover Antigens Targeted by Human T Cells Expressed during Pulmonary Infection, Journal of Immunology 190(4): 1659-1671.
- Greco, E.; Quintiliani, G.; Santucci, M.B.; Serafino, A.; Ciccaglione, A.R.; Caccamo, N.; Nisini, R.; Dieli, F.; Ottenhoff, T.H. & Fraziano, M. (2012), Janus-faced liposomes as a novel immunotherapeutic strategy to enhance anti-microbial innate immune response, Immunology 137: 150-150.
- Geluk, A.; Eeden, S.J.F. van den; Meijgaarden, K.E. van; Dijkman, K.; Franken, K.L.M.C. & Ottenhoff, T.H.M. (2012), A multistage-polyepitope vaccine protects against Mycobacterium tuberculosis infection in HLA-DR3 transgenic mice, Vaccine 30(52): 7513-7521.
- Bobosha, K.; Tang, S.T.; Ploeg-van Schip, J.J. van der; Bekele, Y.; Martins, M.V.S.B.; Lund, O.; Franken, K.L.M.C.; Khadge, S.; Pontes, M.A.D.; Goncalves, H.D.; Hussien, J.; Thapa, P.; Kunwar, C.B.; Hagge, D.A.; Aseffa, A.; Pessolani, M.C.V.; Pereira, G.M.B.; Ottenhoff, T.H.M. & Geluk, A. (2012), Mycobacterium leprae virulence-associated peptides are indicators of exposure to M. leprae in Brazil, Ethiopia and Nepal, Mem�rias do Instituto Oswaldo Cruz. 107: 112-123.
- Joosten, S.A.; Goeman, J.J.; Sutherland, J.S.; Opmeer, L.; Boer, K.G. de; Jacobsen, M.; Kaufmann, S.H.E.; Finos, L.; Magis-Escurra, C.; Ota, M.O.C.; Ottenhoff, T.H.M. & Haks, M.C. (2012), Identification of biomarkers for tuberculosis disease using a novel dual-color RT-MLPA assay, Genes and Immunity 13(1): 71-82.
- Png, E.; Alisjahbana, B.; Sahiratmadja, E.; Marzuki, S.; Nelwan, R.; Balabanova, Y.; Nikolayevskyy, V.; Drobniewski, F.; Nejentsev, S.; Adnan, I.; Vosse, E. van de; Hibberd, M.L.; Crevel, R. van; Ottenhoff, T.H.M. & Seielstad, M. (2012), A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians, BMC Medical Genetics 13: -.
- Romano, M.; Aryan, E.; Korf, H.; Bruffaerts, N.; Franken, C.L.M.C.; Ottenhoff, T.H.M. & Huygen, K. (2012), Potential of Mycobacterium tuberculosis resuscitation-promoting factors as antigens in novel tuberculosis sub-unit vaccines.
- Riano, F.; Arroyo, L.; Paris, S.; Rojas, M.; Friggen, A.H.; Meijgaarden, K.E. van; Franken, K.L.M.C.; Ottenhoff, T.H.M.; Garcia, L.F. & Barrera, L.F. (2012), T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia.
- Kassa, D.; Ran, L.; Geberemeskel, W.; Tebeje, M.; Alemu, A.; Selase, A.; Tegbaru, B.; Franken, K.L.M.C.; Friggen, A.H.; Meijgaarden, K.E. van; Ottenhoff, T.H.M.; Wolday, D.; Messele, T. & Baarle, D. van (2012), Analysis of Immune Responses against a Wide Range of Mycobacterium tuberculosis Antigens in Patients with Active Pulmonary Tuberculosis.
- Geluk, A.; Bobosha, K.; Ploeg-van Schip, J.J. van der; Spencer, J.S.; Banu, S.; Martins, M.V.S.B.; Cho, S.N.; Franken, K.L.M.C.; Kim, H.J.; Bekele, Y.; Uddin, M.K.M.; Hadi, S.A.; Aseffa, A.; Pessolani, M.C.V.; Pereira, G.M.B.; Dockrell, H.M. & Ottenhoff, T.H.M. (2012), New Biomarkers with Relevance to Leprosy Diagnosis Applicable in Areas Hyperendemic for Leprosy, Journal of Immunology 188(10): 4782-4791.
- Thye, T.; Owusu-Dabo, E.; Vannberg, F.O.; Crevel, R. van; Curtis, J.; Sahiratmadja, E.; Balabanova, Y.; Ehmen, C.; Muntau, B.; Ruge, G.; Sievertsen, J.; Gyapong, J.; Nikolayevskyy, V.; Hill, P.C.; Sirugo, G.; Drobniewski, F.; Vosse, E. van de; Newport, M.; Alisjahbana, B.; Nejentsev, S.; Ottenhoff, T.H.M.; Hill, A.V.S.; Horstmann, R.D. & Meyer, C.G. (2012), Common variants at 11p13 are associated with susceptibility to tuberculosis, Nature Genetics 44(3): 257-259.
- Greco, E.; Quintiliani, G.; Santucci, M.B.; Serafino, A.; Ciccaglione, A.R.; Marcantonio, C.; Papi, M.; Maulucci, G.; Delogu, G.; Martino, A.; Goletti, D.; Sarmati, L.; Andreoni, M.; Altieri, A.; Alma, M.; Caccamo, N.; Liberto, D. di; Spirito, M. de; Savage, N.D.; Nisini, R.; Dieli, F.; Ottenhoff, T.H. & Fraziano, M. (2012), Janus-faced liposomes enhance antimicrobial innate immune response in Mycobacterium tuberculosis infection, Proceedings of the National Academy of Sciences 109(21): E1360-E1368.
- Chegou, N.N.; Black, G.F.; Loxton, A.G.; Stanley, K.; Essone, P.N.; Klein, M.R.; Parida, S.K.; Kaufmann, S.H.E.; Doherty, T.M.; Friggen, A.H.; Franken, K.L.; Ottenhoff, T.H. & Walzl, G. (2012), Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting, BMC Infectious Diseases 12: -.
- Png, E.; Alisjahbana, B.; Sahiratmadja, E.; Marzuki, S.; Nelwan, R.; Adnan, I.; Vosse, E. van de; Hibberd, M.; Crevel, R. van; Ottenhoff, T.H.M. & Seielstad, M. (2012), Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians.
- Ottenhoff, T.H.M. (2012), The knowns and unknowns of the immunopathogenesis of tuberculosis.
- Oni, T.; Gideon, H.P.; Bangani, N.; Tsekela, R.; Seldon, R.; Wood, K.; Wilkinson, K.A.; Goliath, R.T.; Ottenhoff, T.H.M. & Wilkinson, R.J. (2012), Smoking, BCG and Employment and the Risk of Tuberculosis Infection in HIV-Infected Persons in South Africa, PLoS ONE 7(10): -.
- Ottenhoff, T.H.M. (2012), New pathways of protective and pathological host defense to mycobacteria, Trends in Microbiology 20(9): 419-428.
- Houben, E.N.G.; Bestebroer, J.; Ummels, R.; Wilson, L.; Piersma, S.R.; Jimenez, C.R.; Ottenhoff, T.H.M.; Luirink, J. & Bitter, W. (2012), Composition of the type VII secretion system membrane complex, Molecular Microbiology 86(2): 472-484.
- Does, A.M. van der; Joosten, S.A.; Vroomans, E.; Bogaards, S.J.P.; Meijgaarden, K.E. van; Ottenhoff, T.H.M.; Dissel, J.T. van & Nibbering, P.H. (2012), The Antimicrobial Peptide hLF1-11 Drives Monocyte-Dendritic Cell Differentiation toward Dendritic Cells That Promote Antifungal Responses and Enhance Th17 Polarization, Journal of Innate Immunity 4(3): 284-292.
- Parsons, S.D.C.; Warren, R.M.; Ottenhoff, T.H.M.; Gey van Pittius, N.C. & Helden, P.D. van (2012), Detection of Mycobacterium tuberculosis infection in dogs in a high-risk setting, Research in Veterinary Science 92(3): 414-419.
- Steenwinkel, J.E.M. de; Knegt, G.J. de; Kate, M.T. ten; Verbrugh, H.A.; Ottenhoff, T.H.M. & Bakker-Woudenberg, I.A.J.M. (2012), Dynamics of interferon-gamma release assay and cytokine profiles in blood and respiratory tract specimens from mice with tuberculosis and the effect of therapy, European Journal of Clinical Microbiology and Infectious Diseases 31(6): 1195-1201.
- Chegou, N.N.; Essone, P.N.; Loxton, A.G.; Stanley, K.; Black, G.F.; Spuy, G.D. van der; Helden, P.D. van; Franken, K.L.; Parida, S.K.; Klein, M.R.; Kaufmann, S.H.E.; Ottenhoff, T.H.M. & Walzl, G. (2012), Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area, PLoS ONE 7(6): -.
- Ottenhoff, T.H.M.; Ellner, J.J. & Kaufmann, S.H.E. (2012), Ten challenges for TB biomarkers.
- Ottenhoff, T.H.M. & Kaufmann, S.H.E. (2012), Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?, PLoS Pathogens 8(5): -.
- Oni, T.; Gideon, H.P.; Bangani, N.; Tsekela, R.; Seldon, R.; Wood, K.; Wilkinson, K.A.; Goliath, R.T.; Ottenhoff, T.H.M. & Wilkinson, R.J. (2012), Risk Factors Associated with Indeterminate Gamma Interferon Responses in the Assessment of Latent Tuberculosis Infection in a High-Incidence Environment.
- Songane, M.; Kleinnijenhuis, J.; Alisjahbana, B.; Sahiratmadja, E.; Parwati, I.; Oosting, M.; Plantinga, T.S.; Joosten, L.A.B.; Netea, M.G.; Ottenhoff, T.H.M.; Vosse, E. van de & Crevel, R. van (2012), Polymorphisms in Autophagy Genes and Susceptibility to Tuberculosis, PLoS ONE 7(8): -.
- Ottenhoff, T.H.M.; Dass, R.H.; Yang, N.H.; Zhang, M.Z.M.; Wong, H.E.E.; Sahiratmadja, E.; Khor, C.C.; Alisjahbana, B.; Crevel, R. van; Marzuki, S.; Seielstad, M.; Vosse, E. van de & Hibberd, M.L. (2012), Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis, PLoS ONE 7(9): -.
- Britten, C.M.; Janetzki, S.; Butterfield, L.H.; Ferrari, G.; Gouttefangeas, C.; Huber, C.; Kalos, M.; Levitsky, H.I.; Maecker, H.T.; Melief, C.J.M.; O'Donnell-Tormey, J.; Odunsi, K.; Old, L.J.; Ottenhoff, T.H.M.; Ottensmeier, C.; Pawelec, G.; Roederer, M.; Roep, B.O.; Romero, P.; Burg, S.H. van der; Walter, S.; Hoos, A. & Davis, M.M. (2012), T Cell Assays and MIATA: The Essential Minimum for Maximum Impact, Immunity 37(1): 1-2.
- Dissel, J.T. van; Soonawala, D.; Joosten, S.A.; Prins, C.; Arend, S.M.; Bang, P.; Tingskov, P.N.; Lingnau, K.; Nouta, J.; Hoff, S.T.; Rosenkrands, I.; Kromann, I.; Ottenhoff, T.H.M.; Doherty, T.M. & Andersen, P. (2011), Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection., Vaccine 29(11): 2100-9.
- Carstens, M.G.; Camps, M.G.M.; Henriksen-Lacey, M.; Franken, K.; Ottenhoff, T.H.M.; Perrie, Y.; Bouwstra, J.A.; Ossendorp, F. & Jiskoot, W. (2011), Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines., Vaccine 29(29-30): 4761-70.
- Carstens, M.G.; Maaden, K. van der; Velden, D. van der; Ottenhoff, T.H.M.; Melief, C.J.; Ossendorp, F.; Bouwstra, J.A. & Jiskoot, W. (2011), Evaluation of the high-pressure extrusion technique as a method for sizing plasmid DNA-containing cationic liposomes., Journal of Liposome Research.
- Reece, S.T.; Nasser-Eddine, A.; Dietrich, J.; Stein, M.; Zedler, U.; Schommer-Leitner, S.; Ottenhoff, T.H.M.; Andersen, P. & Kaufmann, S.H.E. (2011), Improved long-term protection against Mycobacterium tuberculosis Beijing/W in mice after intra-dermal inoculation of recombinant BCG expressing latency associated antigens., Vaccine 29(47): 8740-4.
- Corstjens, P.L.A.M.; Dood, C.J. de; Ploeg-van Schip, J.J. van der; Wiesmeijer, K.C.; Riuttamaki, T.; Meijgaarden, K.E. van; Spencer, J.S.; Tanke, H.J.; Ottenhoff, T.H.M. & Geluk, A. (2011), Lateral flow assay for simultaneous detection of cellular- and humoral immune responses., Clinical Biochemistry.
- Geluk, A.; Eeden, S.J.F. van den; Dijkman, K.; Wilson, L.; Kim, H.J.; Franken, K.L.M.C.; Spencer, J.S.; Pessolani, M.C.V.; Pereira, G.M.B. & Ottenhoff, T.H.M. (2011), ML1419c Peptide Immunization Induces Mycobacterium leprae-Specific HLA-A*0201-Restricted CTL In Vivo with Potential To Kill Live Mycobacteria.
- Abdallah, A.M.; Bestebroer, J.; Savage, N.D.L.; Punder, K. de; Zon, M. van; Wilson, L.; Korbee, C.J.; Sar, A.M. van der; Ottenhoff, T.H.M.; Wel, N.N. van der; Bitter, W. & Peters, P.J. (2011), Mycobacterial Secretion Systems ESX-1 and ESX-5 Play Distinct Roles in Host Cell Death and Inflammasome Activation., The Journal of Immunology 187(9): 4744-53.
- Tchilian, E.Z.; Ronan, E.O.; Lara, C. de; Lee, L.N.; Franken, K.L.M.C.; Vordermeier, M.H.; Ottenhoff, T.H.M. & Beverley, P.C.L. (2011), Simultaneous Immunization against Tuberculosis., PLoS ONE 6(11): e27477.
- Carvalho, R.; Sonneville, J. de; Stockhammer, O.W.; Savage, N.D.L.; Veneman, W.J.; Ottenhoff, T.H.M.; Dirks, R.P.; Meijer, A.H. & Spaink, H.P. (2011), A High-Throughput Screen for Tuberculosis Progression, PLoS ONE 6(2).
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- Commandeur, S.; Meijgaarden, K.E. van; Lin, M.Y.; Franken, K.L.M.C.; Friggen, A.H.; Drijfhout, J.W.; Oftung, F.; Korsvold, G.E.; Geluk, A. & Ottenhoff, T.H.M. (2011), Identification of Human T-Cell Responses to Mycobacterium tuberculosis Resuscitation-Promoting Factors in Long-Term Latently Infected Individuals, Clinical and Vaccine Immunology 18(4): 676-683.
- Geluk, A.; Eeden, S.J.F. van den; Dijkman, K.; Wilson, L.; Kim, H.J.; Franken, K.L.M.C.; Spencer, J.S.; Pessolani, M.C.V.; Pereira, G.M.B. & Ottenhoff, T.H.M. (2011), ML1419c Peptide Immunization Induces Mycobacterium leprae-Specific HLA-A*0201-Restricted CTL In Vivo with Potential To Kill Live Mycobacteria, Journal of Immunology 187(3): 1393-1402.
- Bobosha, K.; Ploeg-Van Schip, J.J. van der; Zewdie, M.; Sapkota, B.R.; Hagge, D.A.; Franken, K.L.M.C.; Inbiale, W.; Aseffa, A.; Ottenhoff, T.H.M. & Geluk, A. (2011), Immunogenicity of Mycobacterium leprae unique antigens in leprosy endemic populations in Asia and Africa, Leprosy Review 82(4): 445-458.
- Lee, L.N.; Ronan, E.O.; Lara, C. de; Franken, K.L.M.C.; Ottenhoff, T.H.M.; Tchilian, E.Z. & Beverley, P.C.L. (2011), CXCR6 Is a Marker for Protective Antigen-Specific Cells in the Lungs after Intranasal Immunization against Mycobacterium tuberculosis, Infection and Immunity 79(8): 3328-3337.
- Oni, T.; Burke, R.; Tsekela, R.; Bangani, N.; Seldon, R.; Gideon, H.P.; Wood, K.; Wilkinson, K.A.; Ottenhoff, T.H.M. & Wilkinson, R.J. (2011), High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB screening, Thorax 66(8): 669-673.
- Carstens, M.G.; Camps, M.G.M.; Henriksen-Lacey, M.; Franken, K.; Ottenhoff, T.H.M.; Perrie, Y.; Bouwstra, J.A.; Ossendorp, F. & Jiskoot, W. (2011), Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines, Vaccine 29(29-30): 4761-4770.
- Dissel, J.T. van; Soonawala, D.; Joosten, S.A.; Prins, C.; Arend, S.M.; Bang, P.; Tingskov, P.N.; Lingnau, K.; Nouta, J.; Hoff, S.T.; Rosenkrands, I.; Kromann, I.; Ottenhoff, T.H.M.; Doherty, T.M. & Andersen, P. (2011), Ag85B-ESAT-6 adjuvanted with IC31 (R) promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection, Vaccine 29(11): 2100-2109.
- Steenwinkel, J.E.M. de; Knegt, G.J. de; Kate, M.T. ten; Verbrugh, H.A.; Ottenhoff, T.H.M. & Bakker-Woudenberg, I.A.J.M. (2011), Dynamics of interferon-gamma release assay and cytokine profiles in blood and respiratory tract specimens from mice with tuberculosis and the effect of therapy., European Journal of Clinical Microbiology and Infectious Diseases.
- Ottenhoff, T.H.M. (2011), New insights and tools to combat leprosy nerve damage, Leprosy Review 82(4): 334-337.
- Commandeur, S.; Lin, M.Y.; Meijgaarden, K.E. van; Friggen, A.H.; Franken, K.L.M.C.; Drijfhout, J.W.; Korsvold, G.E.; Oftung, F.; Geluk, A. & Ottenhoff, T.H.M. (2011), Double- and monofunctional CD4(+) and CD8(+) T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals, European Journal of Immunology 41(10): 2925-2936.
- Corstjens, P.L.A.M.; Dood, C.J. de; Ploeg-van Schip, J.J. van der; Wiesmeijer, K.C.; Riuttamaki, T.; Meijgaarden, K.E. van; Spencer, J.S.; Tanke, H.J.; Ottenhoff, T.H.M. & Geluk, A. (2011), Lateral flow assay for simultaneous detection of cellular- and humoral immune responses, Clinical Biochemistry 44(14-15): 1241-1246.
- Sutherland, J.S.; Hill, P.C.; Adetifa, I.M.; Jong, B.C. de; Donkor, S.; Joosten, S.A.; Opmeer, L.; Haks, M.C.; Ottenhoff, T.H.M.; Adegbola, R.A. & Ota, M.O.C. (2011), Identification of Probable Early-Onset Biomarkers for Tuberculosis Disease Progression, PLoS ONE 6(9): -.
- Carstens, M.G.; Maaden, K. van der; Velden, D. van der; Ottenhoff, T.H.M.; Melief, C.J.; Ossendorp, F.; Bouwstra, J.A. & Jiskoot, W. (2011), Evaluation of the high-pressure extrusion technique as a method for sizing plasmid DNA-containing cationic liposomes, Journal of Liposome Research 21(4): 286-295.
- Chiacchio, T.; Petruccioli, E.; Vanini, V.; Butera, O.; Cuzzi, G.; Petrone, L.; Matteucci, G.; Lauria, F.N.; Franken, K.L.M.C.; Girardi, E.; Ottenhoff, T.H.M. & Goletti, D. (2011), Higher Frequency of T-Cell Response to M. tuberculosis Latency Antigen Rv2628 at the Site of Active Tuberculosis Disease than in Peripheral Blood, PLoS ONE 6(11): -.
- Reece, S.T.; Nasser-Eddine, A.; Dietrich, J.; Stein, M.; Zedler, U.; Schommer-Leitner, S.; Ottenhoff, T.H.M.; Andersen, P. & Kaufmann, S.H.E. (2011), Improved long-term protection against Mycobacterium tuberculosis Beijing/W in mice after intra-dermal inoculation of recombinant BCG expressing latency associated antigens, Vaccine 29(47): 8740-8744.
- Abdallah, A.M.; Bestebroer, J.; Savage, N.D.L.; Punder, K. de; Zon, M. van; Wilson, L.; Korbee, C.J.; Sar, A.M. van der; Ottenhoff, T.H.M.; Wel, N.N. van der; Bitter, W. & Peters, P.J. (2011), Mycobacterial Secretion Systems ESX-1 and ESX-5 Play Distinct Roles in Host Cell Death and Inflammasome Activation, Journal of Immunology 187(9): 4744-4753.
- Tchilian, E.Z.; Ronan, E.O.; Lara, C. de; Lee, L.N.; Franken, K.L.M.C.; Vordermeier, M.H.; Ottenhoff, T.H.M. & Beverley, P.C.L. (2011), Simultaneous Immunization against Tuberculosis, PLoS ONE 6(11): -.
- Dissel, J.T. van; Arend, S.M.; Prins, C.; Bang, P.; Tingskov, P.N.; Lingnau, K.; Nouta, J.; Klein, M.R.; Rosenkrands, I.; Ottenhoff, T.H.M.; Kromann, I.; Doherty, T.M. & Andersen, P. (2010), Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers., Vaccine 28(20): 3571-81.
- Joosten, S.A.; Meijgaarden, K.E. van; Weeren, P.C. van; Kazi, F.; Geluk, A.; Savage, N.D.L.; Drijfhout, J.W.; Flower, D.R.; Hanekom, W.A.; Klein, M.R. & Ottenhoff, T.H.M. (2010), Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity., PLoS Pathogens 6(2): e1000782.
- Dongen, M. van; Savage, N.D.L.; Jordanova, E.S.; Briaire-de Bruijn, I.H.; Walburg, K.V.; Ottenhoff, T.H.M.; Hogendoorn, P.C.W.; Burg, S.H. van der; Gelderblom, H. & Hall, T. van (2010), Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors, International Journal of Cancer 127(4): 899-909.
- Parwati, I.; Alisjahbana, B.; Apriani, L.; Soetikno, R.D.; Ottenhoff, T.H.; Zanden, A.G.M. van der; Meer, J. van der; Soolingen, D. van & Crevel, R. van (2010), Mycobacterium tuberculosis Beijing genotype is an independent risk factor for tuberculosis treatment failure in Indonesia., Journal of Infectious Diseases 201(4): 553-7.
- Dissel, J.T. van; Arend, S.M.; Prins, C.; Bang, P.; Tingskov, P.N.; Lingnau, K.; Nouta, J.; Klein, M.R.; Rosenkrands, I.; Ottenhoff, T.H.M.; Kromann, I.; Doherty, T.M. & Andersen, P. (2010), Ag85B-ESAT-6 adjuvanted with IC31 (R) promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naive human volunteers, Vaccine 28(20): 3571-3581.
- Ottenhoff, T.H.; Doherty, T.M.; Dissel, J.T. van; Bang, P.; Lingnau, K.; Kromann, I. & Andersen, P. (2010), First in humans: A new molecularly defined vaccine shows excellent safety and strong induction of long-lived Mycobacterium tuberculosis-specific Th1-cell like responses, Human Vaccines 6(12): 1007-1015.
- Ottenhoff, T.H.; Doherty, T.M.; Dissel, J.T. van; Bang, P.; Lingnau, K.; Kromann, I. & Andersen, P. (2010), First in humans: a new molecularly defined vaccine shows excellent safety and strong induction of long-lived Mycobacterium tuberculosis-specific Th1-cell like responses., Human Vaccines 6(12): 1007-15.
- Does, A.M. van der; Beekhuizen, H.; Ravensbergen, B.; Vos, T.; Ottenhoff, T.H.M.; Dissel, J.T. van; Drijfhout, J.W.; Hiemstra, P.S. & Nibbering, P.H. (2010), LL-37 Directs Macrophage Differentiation toward Macrophages with a Proinflammatory Signature, Journal of Immunology 185(3): 1442-1449.
- Vosse, E. van de; Ottenhoff, T.H.M.; Paus, R.A. de; Verhard, E.M.; Boer, T. de; Dissel, J.T. van & Kuijpers, T.W. (2010), Mycobacterium bovis BCG-itis and cervical lymphadenitis due to Salmonella enteritidis in a patient with complete interleukin-12/-23 receptor beta1 deficiency.
- Hall, T. van; Oliveira, C.C.; Joosten, S.A. & Ottenhoff, T.H.M. (2010), The other Janus face of Qa-1 and HLA-E diverse peptide repertoires in times of stress, Microbes and Infection 12(12-13): 910-918.
- Parwati, I.; Alisjahbana, B.; Apriani, L.; Soetikno, R.D.; Ottenhoff, T.H.; Zanden, A.G.M. van der; Meer, J. van der; Soolingen, D. van & Crevel, R. van (2010), Mycobacterium tuberculosis Beijing Genotype Is an Independent Risk Factor for Tuberculosis Treatment Failure in Indonesia, Journal of Infectious Diseases 201(4): 553-557.
- Geluk, A.; Ploeg-van Schip, J.J. van der; Meijgaarden, K.E. van; Commandeur, S.; Drijfhout, J.W.; Benckhuijsen, W.E.; Franken, K.L.M.C.; Naafs, B. & Ottenhoff, T.H.M. (2010), Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assays.
- Fears, R.; Kaufmann, S.; Meulen, V. ter; Zumla, A. & EASAC Working Grp (2010), Drug-resistant tuberculosis in the European Union: Opportunities and challenges for control, Tuberculosis 90(3): 182-187.
- Vosse, E. van de; Ottenhoff, T.H.M.; Paus, R.A. de; Verhard, E.M.; Boer, T. de; Dissel, J.T. van & Kuijpers, T.W. (2010), Mycobacterium bovis BCG-itis and Cervical Lymphadenitis due to Salmonella enteritidis in a Patient with Complete Interleukin-12/-23 Receptor beta 1 Deficiency, Infection 38(2): 128-130.
- Nemec, A. & Dijkshoorn, L. (2010), Variations in colistin susceptibility among different species of the genus Acinetobacter, Journal of Antimicrobial Chemotherapy 65(2): 367-369.
- Joosten, S.A.; Meijgaarden, K.E. van; Weeren, P.C. van; Kazi, F.; Geluk, A.; Savage, N.D.L.; Drijfhout, J.W.; Flower, D.R.; Hanekom, W.A.; Klein, M.R. & Ottenhoff, T.H.M. (2010), Mycobacterium tuberculosis Peptides Presented by HLA-E Molecules Are Targets for Human CD8(+) T-Cells with Cytotoxic as well as Regulatory Activity, PLoS Pathogens 6(2).
- Parwati, I.; Alisjahbana, B.; Apriani, L.; Soetikno, R.D.; Ottenhoff, T.H.; Zanden, A.G.M. van der; Meer, J. van der; Soolingen, D. van & Crevel, R. van (2010), Mycobacterium tuberculosis Beijing Genotype Is an Independent Risk Factor for Tuberculosis Treatment Failure in Indonesia, Journal of Infectious Diseases 201(4): 553-557.
- Joosten, S.A. & Ottenhoff, T.H.M. (2010), Comment on "CCR5 Dictates the Equilibrium of Proinflammatory IL-17(+) and Regulatory Foxp3(+) T Cells in Fungal Infections", Journal of Immunology 185(3): 1351-1351.
- Mattos, A.M.M.; Almeida, C.D.; Franken, K.L.M.C.; Alves, C.C.D.; Abramo, C.; Souza, M.A. de; L'Hotellier, M.; Alves, M.J.M.; Ferreira, A.P.; Oliveira, S.C.; Ottenhoff, T.H.M. & Teixeira, H.C. (2010), Increased IgG1, IFN-gamma, TNF-alpha and IL-6 responses to Mycobacterium tuberculosis antigens in patients with Tuberculosis are lower after chemotherapy, International Immunology 22(9): 775-782.
- Kraaij, M.D.; Savage, N.D.L.; Kooij, S.W. van der; Koekkoek, K.; Wang, J.; Berg, J.M. van den; Ottenhoff, T.H.M.; Kuijpers, T.W.; Holmdahl, R.; Kooten, C. van & Gelderman, K.A. (2010), Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species, Proceedings of the National Academy of Sciences 107(41): 17686-17691.
- Caccamo, N.; Guggino, G.; Joosten, S.A.; Gelsomino, G.; Carlo, P. di; Titone, L.; Galati, D.; Bocchino, M.; Matarese, A.; Salerno, A.; Sanduzzi, A.; Franken, W.P.J.; Ottenhoff, T.H.M. & Dieli, F. (2010), Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection, European Journal of Immunology 40(8): 2211-2220.
- Goletti, D.; Butera, O.; Vanini, V.; Lauria, F.N.; Lange, C.; Franken, K.L.M.C.; Angeletti, C.; Ottenhoff, T.H.M. & Girardi, E. (2010), Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection, European Respiratory Journal 36(1): 135-142.
- Caccamo N, Guggino G, Meraviglia S, Gelsomino G, Di Carlo P, Titone L, Bocchino M, Galati D, Matarese A, Nouta J, Klein MR, Salerno A, Sanduzzi A, Dieli F & Ottenhoff TH (2009), Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection, PLoS ONE 4(5).
- Doherty M, Wallis RS, Zumla A, WHO-Tropical Diseases Research/Euroepan Commission joint expert consultation group (Akuffo H, Aseffa A, Klein N, Lang H, Locht C, Mitchison D, Narayanan P, Nunn A, Olesen O, Onyebujoh P, Ottenhoff TH, Parida S, Vahedi M & van Soolingen D (2009), Biomarkers for tuberculosis disease status and diagnosis, Current Opinion in Pulmonary Medicine 15(3): 181-187.
- Verreck FAW, Vervenne RAW, Kondova I, van Kralingen KW, Remarque EJ, Braskamp G, van der Werff NM, Kersbergen A, Ottenhoff THM, Heidt PJ, Gilbert SC, Gicquel B, Hill AV, Martin C, McShane H & Tomas AW (2009), MVA.85A Boosting of BCG and an Attenuated, phoP Deficient M. tuberculosis Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques, PLoS ONE 4(4).
- Schuck SD, Mueller H, Kunitz F, Neher A, Hoffmann H, Franken KLCM, Repsilber D, Ottenhoff THM, Kaufmann SHE & Jacobsen M (2009), Identification of T-Cell Antigens Specific for Latent Mycobacterium Tuberculosis Infection, PLoS ONE 4(5).
- Kleinnijenhuis J, Joosten LAB, van de Veerdonk FL, Savage N, van Crevel R, Kullberg BJ, van der Ven A, Ottenhoff THM, Dinarello CA, van der Meer JWM & Netea MG (2009), Transcriptional and inflammasome-mediated pathways for the induction of IL-1 beta production by Mycobacterium tuberculosis, European Journal of Immunology 39(7): 1914-1922.
- Bivas-Benita M, Lin MY, Bal SM, van Meijgaarden KE, Franken KLMC, Friggen AH, Junginger HE, Borchard G, Klein MR & Ottenhoff THM (2009), Pulmonary delivery of DNA encoding Mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA-PEI nanoparticles enhances T cell responses in a DNA prime/protein boost vaccination regimen in mice, Vaccine 27(30): 4010-4017.
- Ottenhoff THM (2009), Overcoming the global crisis: "Yes, we can", but also for TB ... ?, European Journal of Immunology 39(8): 2014-2020.
- van Crevel R, Parwati I, Sahiratmadja E, Marzuki S, Ottenhoff THM, Netea MG, van der Ven A, Nelwan RH, van der Meer JW, Alisjahbana B & van de Vosse E (2009), Infection with Mycobacterium tuberculosis Beijing Genotype Strains Is Associated with Polymorphisms in SLC11A1/NRAMP1 in Indonesian Patients with Tuberculosis.
- Black GF, Thiel BA, Ota MO, Parida SK, Adegbola R, Boom WH, Dockrell HM, Franken KLMC, Friggen AH, Hill PC, Klein MR, Lalor MK, Mayanja H, Schoolnik G, Stanley K, Weldringh K, Kaufmann SH, Waltzl G & Ottenhof THM (2009), Immunogenicity of Novel DosR Regulon-Encoded Candidate Antigens of Mycobacterium tuberculosis in Three High-Burden Populations in Africa, Clinical and Vaccine Immunology 16(8): 1203-1212.
- Smith SG, Joosten SA, Verscheure V, Pathan AA, McShane H, Ottenhoff THM, Dockrell HM & Mascart F (2009), Identification of Major Factors Influencing ELISpot-Based Monitoring of Cellular Responses to Antigens from Mycobacterium tuberculosis, PLoS ONE 4(11).
- van de Vosse E, van Dissel JT & Ottenhoff THM (2009), Genetic deficiencies of innate immune signalling in human infectious disease, Lancet Infectious Diseases 9(11): 688-698.
- Arend SM, van Soolingen D & Ottenhoff THM (2009), Diagnosis and treatment of lung infection with nontuberculous mycobacteria, Current Opinion in Pulmonary Medicine 15(3): 201-208.
- Lin MY, Reddy TBK, Arend SM, Friggen AH, Franken KLMC, van Meijgaarden KE, Verduyn MJC, Schoolnik GK, Klein MR & Ottenhoff THM (2009), Cross-Reactive Immunity to Mycobacterium tuberculosis DosR Regulon-Encoded Antigens in Individuals Infected with Environmental, Nontuberculous Mycobacteria, Infection and Immunity 77(11): 5071-5079.
- Spencer JS, Kim HJ, Roa RL, Marques MAM, da Silva R, Groathouse NA, Williams DL, Ottenhoff THM, Geluk A, Cho SN, Gelber R, Dockrell HM, Cole ST, Britton WJ, Duthie MS, Ireton G, Pessolani MCV, Slayden RA & Brennan PJ (2008), The use of proteomics and bioinformatics to identify novel antigens of Mycobacterium leprae towards the development of a rapid diagnostic test for the early detection of leprosy, Infection, Genetics and Evolution 8(4).
- Portugal MI, Todeschini AR, de Lima CS, Silva CAM, Mohana-Borges R, Ottenhoff THM, Mendonca-Previato L, Previato JO & Pessolani MCV (2008), Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp, BMC Microbiology 8.
- Savage NDL, de Boer T, Walburg KV, Joosten SA, van Meijgaarden K, Geluk A & Ottenhoff THM (2008), Human anti-inflammatory macrophages induce Foxp3(+)GITR(+)CD25(+) regulatory T cells, which suppress via membrane-bound TGF beta-1, Journal of Immunology 181(3).
- Geluk, A.; Ploeg, J. van der; Teles, R.O.B.; Franken, K.L.M.C.; Prins, C.; Drijfhout, J.W.; Sarno, E.N.; Sampaio, E.P. & Ottenhoff, T.H.M. (2008), Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for Immunodiagnosis of M-leprae infection, Clinical and Vaccine Immunology 15(3).
- Hanekom WA, Dockrell HM, Ottenhoff THM, Doherty TM, Fletcher H, McShane H, Weichold FF, Hoft DF, Parida SK & Fruth UJ (2008), Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations, PLoS Medicine 5(7).
- Schuck, S.D.; Kunitz, F.; Mueller, H.; Franken, K.L.; Ottenhoff, T.H.; Kaufmann, S.H. & Jacobsen, M. (2008), T-cell responses against subdominant antigens indicate latent M. tuberculosis infection, Wiener Klinische Wochenschrift 120.
- de Boer T, van Dissel JT, Kuijpers TWJ, Rimmelzwaan GF, Kroon FP & Ottenhoff THM (2008), Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I, Clinical and Vaccine Immunology 15(8).
- Lin MY & Ottenhoff THM (2008), Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection, Biological Chemistry 389(5).
- Abdallah AM, Savage NDL, van Zon M, Wilson L, Vandenbroucke-Grauls CMJE, van der Wel NN, Ottenhoff THM & Bitter W (2008), The ESX-5 Secretion System of Mycobacterium marinum Modulates the Macrophage Response, Journal of Immunology 181(10).
- Corstjens PLAM, Zuiderwijk M, Tanke HJ, Schip JJVV, Ottenhoff THM & Geluk A (2008), A user-friendly, highly sensitive assay to detect the IFN-gamma secretion by T cells, Clinical Biochemistry 41(6).
- Amim L, Pacheco A, Fonseca-Costa J, Loredo C, Rabahi M, Melo M, Ribeiro F, Mello F, Oliveira M, Silva JRLE, Ottenhoff T, Kritski A & Santos A (2008), Role of IFN-gamma+874 T/A single nucleotide polymorphism in the tuberculosis outcome among Brazilians subjects, Molecular Biology Reports 35(4).
- Davila S, Hibberd ML, Dass RH, Wong HEE, Sahiratmadja E, Bonnard C, Alisjahbana B, Szeszko JS, Balabanova Y, Drobniewski F, van Crevel R, van de Vosse E, Nejentsev S, Ottenhoff THM & Seielstad M (2008), Genetic Association and Expression Studies Indicate a Role of Toll-Like Receptor 8 in Pulmonary Tuberculosis, PLoS Genetics 4(10).
- Nejentsev S, Thye T, Szeszko JS, Stevens H, Balabanova Y, Chinbuah AM, Hibberd M, van de Vosse E, Alisjahbana B, Van Crevel R, Ottenhoff THM, Png E, Drobniewski F, Todd JA, Seielstad M & Horstmann RD (2008), Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations, Nature Genetics 40(3).
- Joosten SA & Ottenhoff THM (2008), Human CD4 and CD8 regulatory T cells in infectious diseases and vaccination, Human Immunology 69(11).
- Stalenhoef JE, Alisjahbana B, Nelwan EJ, van der Ven-Jongekrijg J, Ottenhoff THM, van der Meer JWM, Nelwan RH, Netea MG & van Crevel R (2008), The role of interferon-gamma in the increased tuberculosis risk in type 2 diabetes mellitus, European Journal of Clinical Microbiology and Infectious Diseases 27(2).
- Ottenhoff T (2007), Lack of immune responses to Mycobacterium tuberculosis: DosR regulon proteins following BCG vaccination, Tropical Medicine and International Health 12.
- Ferwerda G, de Jong DJ, van Crevel R, Ottenhoff THM, van der Meer JWM, Kullberg BJ & Netea MG (2007), Impaired immune recognition of M. tuberculosis and M. paratuberculosis in Crohn patients homozygous for the NOD2 3020insC mutation, European Journal of Gastroenterology and Hepatology 19(10).
- Kuijl C, Savage NDL, Marsman M, Tuin AW, Janssen L, Egan DA, Ketema M, van den Nieuwendijk R, van den Eeden SJF, Geluk A, Poot A, van der Marel G, Beijersbergen RL, Overkleeft H, Ottenhoff THM & Neefjes J (2007), Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1, Nature 450(7170).
- Vordermeier HM, Brown J, Cockle PJ, Franken WPJ, Drijfhout JW, Arend SM, Ottenhoff THM, Jahans K & Hewinson RG (2007), Assessment of cross-reactivity between Mycobacterium bovis and M. kansasii ESAT-6 and CFP-10 at the T-Cell epitope level (vol 14, pg 1203, 2007).
- Sahiratmadja E, Wieringa FT, van Crevel R, de Visser AW, Adnan I, Alisjahbana B, Slagboom E, Marzuki S, Ottenhoff THM, van de Vosse E & Marx JJA (2007), Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3/UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population, British Journal of Nutrition 98(4).
- Parkash, O.; Kumar, A.; Pandey, R.; Girdhar, B.K.; Franken, K.L.M.C. & Ottenhoff, T.H.M. (2007), Serological heterogeneity against various Mycobacterium leprae antigens and its use in serodiagnosis of leprosy patients, Journal of Medical Microbiology 56(9).
- Ferwerda G, Kullberg BJ, de Jong DJ, Girardin SE, Langenberg DML, van Crevel R, Ottenhoff THM, van der Meer JWM & Netea MG (2007), Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2, Journal of Leukocyte Biology 82(4).
- Vordermeier HM, Brown J, Cockle PJ, Franken WPJ, Arend SM, Ottenhoff THM, Jahans K & Hewinson RG (2007), Assessment of cross-re activity between Mycobacterium bovis and M-kansasii ESAT-6 and CFP-10 at the T-Cell epitope level, Clinical and Vaccine Immunology 14(9).
- Martinez V, Carcelain G, Badell E, Jouan M, Mauger I, Sellier P, Truffot C, Bricaire F, Arend SM, Ottenhoff T, Autran B & Gicquel B (2007), T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals, BMC Infectious Diseases 7.
- Noordzij JG, Hartwig NG, Verreck FAW, de Bruin-Versteeg S, de Boer T, van Dissel JT, de Groot R, Ottenhoff THM & van Dongen JJM (2007), Two patients with complete defects in interferon gamma receptor-dependent signaling, Journal of Clinical Immunology 27(5).
- Parkash, O.; Kumar, A.; Pandey, R.; Franken, K.L.M.C. & Ottenhoff, T.H.M. (2007), Detection of Mycobacterium leprae infection employing a combinatorial approach of anti-45 kDa and modified anti-PGL-I antibody detection assays, Journal of Medical Microbiology 56(8).
- Sahiratmadja E, Alisjahbana B, Buccheri S, Di Liberto D, de Boer T, Adnan I, van Crevel R, Klein MR, van Meijgaarden KE, Nelwan RHH, van de Vosse E, Dieli F & Ottenhoff THM (2007), Plasma granulysin levels and cellular interferon-gamma production correlate with curative host responses in tuberculosis, while plasma interferon-gamma levels correlate with tuberculosis disease activity in adults, Tuberculosis 87(4).
- Sahiratmadja E, Baak-Pablo R, Visser AW, Alisjahbana B, Adnan I, van Crevel R, Marzuki S, van Dissel JT, Ottenhoff THM & van de Vosse E (2007), Association of polymorphisms in IL-12/IFN-gamma pathway genes with susceptibility to pulmonary tuberculosis in Indonesia, Tuberculosis 87(4).
- Alisjahbana B, Sahiratmadja E, Nelwan EJ, Purwa AM, Ahmad Y, Ottenhoff THM, Nelwan RHH, Parwati I, van der Meer JWM & van Crevel R (2007), The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis, Clinical Infectious Diseases 45(4).
- Leyten EMS, Arend SM, Prins C, Cobelens FGJ, Ottenhoff THM & van Dissel JT (2007), Discrenancy between Mycobacterium tuberculosis-specific gamma interferon release assays using short and prolonged in vitro incubation, Clinical and Vaccine Immunology 14(7).
- Lin, M.Y.; Geluk, A.; Smith, S.G.; Stewart, A.L.; Friggen, A.H.; Franken, K.L.M.C.; Verduyn, M.J.C.; Meijgaarden, K.E. van; Voskuil, M.I.; Dockrell, H.M.; Huygen, K.; Ottenhoff, T.H.M. & Klein, M.R. (2007), Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination, Infection and Immunity 75(7).
- Leyten EMS, Prins C, Bossink AWJ, Thijsen S, Ottenhoff THM, van Dissel JT & Arend SM (2007), Effect of tuberculin skin testing on a Mycobacterium tuberculosis-specific interferon-gamma assay, European Respiratory Journal 29(6).
- Geluk, A.; Lin, M.Y.; Meijgaarden, K.E. van; Leyten, E.A.S.; Franken, K.L.M.C.; Ottenhoff, T.H.M. & Klein, M.R. (2007), T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M-tuberculosis infection but not with M-bovis BCG vaccination, Infection and Immunity 75(6).
- Sahiratmadja E, Alisjahbana B, de Boer T, Adnan I, Maya A, Danusantoso H, Danusantoso R, Nelwan RHH, Marzuki S, van der Meer JWM, van Crevel R, van de Vosse E & Ottenhoff THM (2007), Dynamic changes in pro- and anti-inflammatory cytokine profiles and gamma interferon receptor signaling integrity correlate with tuberculosis disease activity and response to curative treatment, Infection and Immunity 75(2).
- Roupie, V.; Romano, M.; Zhang, L.; Korf, H.; Lin, M.Y.; Franken, K.L.M.C.; Ottenhoff, T.H.M.; Klein, M.R. & Huygen, K. (2007), Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice, Infection and Immunity 75(2).
- Joosten SA, van Meijgaarden KE, Savage NDL, de Boert T, Triebel F, van der Wal A, de Heer E, Klein MR, Geluk A & Ottenhoff THM (2007), Identification of a human CD8(+) regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4, Proceedings of the National Academy of Sciences 104(19).
- van de Vosse E & Ottenhoff THM (2006), Human host genetic factors in mycobacterial and Salmonella infection: lessons from single gene disorders in IL-12/IL-23-dependent signaling that affect innate and adaptive immunity, Microbes and Infection 8(4).
- Alisjahbana B, van Crevel R, Sahiratmadja E, den Heijer M, Maya A, Istriana E, Danusantoso H, Ottenhoff THM, Nelwan RHH & van der Meer JWM (2006), Diabetes mellitus is strongly associated with tuberculosis in Indonesia, International Journal of Tuberculosis and Lung Disease 10(6).
- Geluk A & Ottenhoff THM (2006), HLA and leprosy in the pre and postgenomic eras, Human Immunology 67(6).
- Sanal O, Turul T, De Boer T, Van de Vosse E, Yalcin I, Tezcan I, Sun C, Memis L, Ottenhoff THM & Ersoy F (2006), Presentation of interleukin-12/-23 receptor beta 1 deficiency with various clinical symptoms of salmonella infections, Journal of Clinical Immunology 26(1).
- Demissie A, Leyten EMS, Abebe M, Wassie L, Aseffa A, Abate G, Fletcher H, Owiafe P, Hill PC, Brookes R, Ottenhoff THM, Andersen P & Doherty TM (2006), Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis, Clinical and Vaccine Immunology 13(2).
- Netea MG, Azam T, Lewis EC, Joosten LAB, Wang MR, Langenberg D, Chan ED, Yoon DY, Ottenhoff T, Kim SH & Dinarello CA (2006), Mycobacterium tuberculosis induces interleukin-32 production through a caspase1/IL-18/interferon-gamma-dependent mechanism, PLoS Medicine 3(8).
- Parkash O, Kumar A, Nigam A, Franken KLMC & Ottenhoff THM (2006), Evaluation of recombinant serine-rich 45-kDa antigen (ML0411) for detection of antibodies in leprosy patients, Scandinavian Journal of Immunology 64(4).
- Leyten, E.M.S.; Lin, M.Y.; Franken, K.L.M.C.; Friggen, A.H.; Prins, C.; Meijgaarden, K.E. van; Voskuil, M.I.; Weldingh, K.; Andersen, P.; Schoolnik, G.K.; Arend, S.M.; Ottenhoff, T.H.M. & Klein, M.R. (2006), Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis, Microbes and Infection 8(8).
- Leyten EMS, Mulder B, Prins C, Weldingh K, Andersen P, Ottenhoff THM, van Dissel JT & Arend SM (2006), Use of enzyme-linked immunospot assay with Mycobacterium tuberculosis-specific peptides for diagnosis of recent infection with m. tuberculosis after accidental laboratory exposure, Journal of Clinical Microbiology 44(3).
- Hoeve MA, Savage NDL, de Boer T, Langenberg DML, Malefyt RD, Ottenhoff THM & Verreck FAW (2006), Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells, European Journal of Immunology 36(3).
- Verreck FAW, de Boer T, Langenberg DML, van der Zanden L & Ottenhoff THM (2006), Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation, Journal of Leukocyte Biology 79(2).
- Wood PMD, Fieschi C, Picard C, Ottenhoff THM, Casanova JL & Kumararatne DS (2005), Inherited defects in the interferon-gamma receptor or interleukin-12 signalling pathways are not sufficient to cause allergic disease in children, European Journal of Pediatrics 164(12).
- Bivas-Benita M, Ottenhoff THM, Junginger HE & Borchard G (2005), Pulmonary DNA vaccination: Concepts, possibilities and perspectives, Journal of Controlled Release 107(1).
- de Lima CS, Zulianello L, Marques MAD, Kim H, Portugal MI, Antunes SL, Menozzi FD, Ottenhoff THM, Brennan PJ & Pessolani MCV (2005), Mapping the laminin-binding and adhesive domain of the cell surface-associated Hlp/LBP protein from Mycobacterium leprae, Microbes and Infection 7(9-10).
- Geluk, A.; Klein, M.R.; Franken, K.L.M.C.; Meijgaarden, K.E. van; Wieles, B.; Pereira, K.C.; Buhrer-Sekula, S.; Klatser, P.R.; Brennan, P.J.; Spencer, J.S.; Williams, D.L.; Pessolani, M.C.V.; Sampaio, E.P. & Ottenhoff, T.H.M. (2005), Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection, Infection and Immunity 73(9).
- Antas, P.R.Z.; Cardoso, F.L.L.; Pereira, K.C.; Franken, K.L.M.C.; Cunha, K.S.; Klatser, P.; Sarno, E.N.; Ottenhoff, T.H.M. & Sampaio, E.P. (2005), T cell immune responses to mycobacterial antigens in Brazilian tuberculosis patients and controls, Transactions of The Royal Society of Tropical Medicine and Hygiene 99(9).
- Fortes A, Pereira K, Antas PRZ, Franken CLMC, Dalcolmo M, Ribeiro-Carvalho MM, Cunha KS, Geluk A, Kritski A, Kolk A, Klatser P, Sarno EN, Ottenhoff THM & Sampaio EP (2005), Detection of in vitro interferon-gamma and serum tumour necrosis factor-alpha in multidrug-resistant tuberculosis patients, Clinical and Experimental Immunology 141(3).
- Hill, P.C.; Jackson-Sillah, D.; Fox, A.; Franken, K.L.M.C.; Lugos, M.D.; Jeffries, D.J.; Donkor, S.A.; Hammond, A.S.; Adegbola, R.A.; Ottenhoff, T.H.M.; Klein, M.R. & Brookes, R.H. (2005), ESAT-6/CFP-10 fusion protein and peptides for optimal diagnosis of Mycobacterium tuberculosis infection by ex vivo enzyme-linked immunospot assay in The Gambia, Journal of Clinical Microbiology 43(5).
- Ressing, M.E.; Leeuwen, D. van; Verreck, F.A.W.; Keating, S.; Gomez, R.; Franken, K.L.M.C.; Ottenhoff, T.H.M.; Spriggs, M.; Schumacher, T.N.; Hutt-Fletcher, L.M.; Rowe, M. & Wiertz, E.J.H.J. (2005), Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion, Journal of Virology 79(2).
- Morgan ME, van Bilsen JHM, Bakker AM, Heemskerk B, Schilham MW, Hartgers FC, Elferink BG, van der Zanden L, de Vries RRP, Huizinga TWJ, Ottenhoff THM & Toes REM (2005), Expression of FOXP3 mRNA is not confined to CD4(+)CD25(+) T regulatory cells in humans, Human Immunology 66(1).
- Ottenhoff THM, Verreck FAW, Hoeve MA & van de Vosse E (2005), Control of human host immunity to mycobacteria, Tuberculosis 85(1-2).
- Williams, A.; Hatch, G.J.; Clark, S.O.; Gooch, K.E.; Hatch, K.A.; Hall, G.A.; Huygen, K.; Ottenhoff, T.H.M.; Franken, K.L.M.C.; Andersen, P.; Doherty, T.M.; Kaufmann, S.H.E.; Grode, L.; Seiler, P.; Martin, C.; Gicquel, B.; Cole, S.T.; Brodin, P.; Pym, A.S.; Dalemans, W.; Cohen, J.; Lobet, Y.; Goonetilleke, N.; McShane, H.; Hill, A.; Parish, T.; Smith, D.; Stoker, N.G.; Lowrie, D.B.; Kallenius, G.; Svenson, S.; Pawowski, A.; Blake, K. & Marsh, P.D. (2005), Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis, Tuberculosis 85(1-2).
- Aagaard C, Brock I, Olsen A, Ottenhoff THM, Weldingh K & Andersen P (2004), Mapping immune reactivity toward Rv2653 and Rv2654: Two novel low-molecular-mass antigens found specifically in the Mycobacterium tuberculosis complex, Journal of Infectious Diseases 189(5).
- Ottenhoff THM (2004), Genetics of type-I cytokines in human intracellular infectious diseases: a spectrum of novel genetic deficiencies demonstrates the essential role of type-I cytokines in immunity against nontuberculous mycobacteria, M-bovis BCG and salmonellae, Netherlands Journal of Medicine 62(3).
- Verreck FAW, de Boer T, Langenberg DML, Hoeve MA, Kramer M, Vaisberg E, Kastelein R, Kolk A, de Waal-Malefyt R & Ottenhoff THM (2004), Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2, macrophages subvert, immunity to (myco)bacteria, Proceedings of the National Academy of Sciences 101(13).
- Bivas-Benita, M.; Meijgaarden, K.E. van; Franken, K.L.M.C.; Junginger, H.E.; Borchard, G.; Ottenhoff, T.H.M. & Geluk, A. (2004), Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis, Vaccine 22(13-14).
- Romano M, Denis O, D'Souza S, Wang XM, Ottenhoff THM, Brulet JM & Huygen K (2004), Induction of in vivo functional D-b-restricted cytolytic T cell activity against a putative phosphate transport receptor of Mycobacterium tuberculosis, Journal of Immunology 172(11).
- Geluk, A.; Meijgaarden, K.E. van; Franken, K.L.M.C.; Wieles, B.; Arend, S.M.; Faber, W.R.; Naafs, B. & Ottenhoff, T.H.M. (2004), Immunological crossreactivity of the Mycobacterium leprae CFP-10 with its homologue in Mycobacterium tuberculosis, Scandinavian Journal of Immunology 59(1).
- Bayley JP, Ottenhoff THM & Verweij CL (2004), Is there a future for TNF promoter polymorphisms?, Genes and Immunity 5(5).
- Ottenhoff THM & Bevan MJ (2004), Host-pathogen interactions - Editorial overview, Current Opinion in Immunology 16(4).
- Vanderborght PR, Matos HJ, Salles AM, Vasconcellos SE, Silva VF, Huizinga TWJ, Ottenhoff THM, Sampaio EP, Sarno EN, Santos AR & Moraes MO (2004), Single nucleoticle polymorphisms (SNPs) at -238 and -308 positions in the TNF alpha promoter: Clinical and bacteriological evaluation in leprosy, International Journal of Leprosy and Other Mycobacterial Diseases 72(2).
- Arend SM, de Palou EC, de Haas P, Janssen R, Hoeve MA, Verhard EM, Ottenhoff THM, van Soolingen D & van Dissel JT (2004), Pneumonia caused by Mycobacterium kansasii in a series of patients without recognised immune defect, Clinical Microbiology and Infection 10(8).
- Janssen R, van Wengen A, Hoeve MA, ten Dam M, van der Burg M, van Dongen J, van de Vosse E, van Tol M, Bredius R, Ottenhoff TH, Weemaes C, van Dissel JT & Lankester A (2004), The same I kappa KB alpha mutation in two related individuals leads to completely different clinical syndromes, Journal of Experimental Medicine 200(5).
- MacLennan C, Fieschi C, Lammas DA, Picard C, Dorman SE, Sanal O, MacLennan JM, Holland SM, Ottenhoff THM, Casanova JL & Kumararatne DS (2004), Interleukin (IL)-12 and IL-23 are key cytokines for immunity against salmonella in humans, Journal of Infectious Diseases 190(10).
- Moraes MO, Pacheco AG, Schonkeren JJM, Vanderborght PR, Nery JAC, Santos AR, Moraes ME, Moraes JR, Ottenhoff THM, Sampaio EP, Huizinga TWJ & Sarno EN (2004), Interleukin-10 promoter single-nucleotide polymorphisms as markers for disease susceptibility and disease severity in leprosy, Genes and Immunity 5(7).
- Bivas-Benita M, Oudshoorn M, Romeijn S, van Meijgaarden K, Koerten H, van der Meulen H, Lambert G, Ottenhoff T, Benita S, Junginger H & Borchard G (2004), Cationic submicron emulsions for pulmonary DNA immunization, Journal of Controlled Release 100(1).
- van Bergen J, Thompson A, van der Slik A, Ottenhoff THM, Gussekloo J & Koning F (2004), Phenotypic and functional characterization of CD4 T cells expressing killer Ig-like receptors, Journal of Immunology 173(11).
- van de Vosse E, Hoeve MA & Ottenhoff THM (2004), Human genetics of intracellular infectious diseases: molecular and cellular immunity against mycobacteria and salmonellae, Lancet Infectious Diseases 4(12).
- van de Vosse E, Lichtenauer-Kaligis EGR, van Dissel JT & Ottenhoff THM (2003), Genetic variations in the interleukin-12/interleukin-23 receptor (beta 1) chain, and implications for IL-12 and IL-23 receptor structure and function, Immunogenetics 54(12).
- Moraes MO, Santos AR, Schonkeren JJM, Vanderborght PR, Ottenhoff THM, Moraes ME, Moraes JR, Sampaio EP, Sarno EN & Huizinga TWJ (2003), Interleukin-10 promoter haplotypes are differently distributed in the Brazilian versus the Dutch population, Immunogenetics 54(12).
- Hoeve MA, de Boer T, Langenberg DML, Sanal O, Verreck FAW & Ottenhoff THM (2003), IL-12 receptor deficiency revisited: IL-23-mediated signaling is also impaired in human genetic IL-12 receptor beta 1 deficiency, European Journal of Immunology 33(12).
- Okkels LM, Brock I, Follmann F, Agger EM, Arend SM, Ottenhoff THM, Oftung F, Rosenkrands I & Andersen P (2003), PPE protein (Rv3873) from DNA segment RD1 of Mycobacterium tuberculosis: Strong recognition of both specific T-cell epitopes and epitopes conserved within the PPE family, Infection and Immunity 71(11).
- Ressing ME, van Leeuwen D, Verreck FAW, Gomez R, Heemskerk B, Toebes M, Mullen MM, Jardetzky TS, Longnecker R, Schilham MW, Ottenhoff THM, Neefjes J, Schumacher TN, Hutt-Fletcher LM & Wiertz EJHJ (2003), Interference with T cell receptor-HLA-DR interactions by Epstein-Barr virus gp42 results in reduced T helper cell recognition, Proceedings of the National Academy of Sciences 100(20).
- Lichtenauer-Kaligis EGR, de Boer T, Verreck FAW, van Voorden S, Hoeve MA, van de Vosse E, Ersoy F, Tezcan H, van Dissel JT, Sanal O & Ottenhoff THM (2003), Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor beta 1 deficient patients and evidence for the existence of partial IL-12 receptor beta 1 deficiency, European Journal of Immunology 33(1).
- Ottenhoff THM, De Boer T, van Dissel JT & Verreck FAW (2003), Human deficiencies in type-1 cytokine receptors reveal the essential role of type-1 cytokines in immunity to intracellular bacteria, Advances in Experimental Medicine and Biology 531.
- Subronto, Y.W.; Meijgaarden, K.E. van; Geluk, A.; Arend, S.M.; Sunardi, T.; Franken, K.L.M.C.; Hisyam, B.; Vries, R.R.P. de; Ottenhoff, T.H.M.; Marzuki, S.; Verhoef, J. & Snippe, H. (2003), Interferon-gamma production in response to M-tuberculosis antigens in TB patients in Indonesia, Advances in Experimental Medicine and Biology 531.
- Kriek NMAJ, van der Hout E, Kelly P, van Meijgaarden KE, Geluk A, Ottenhoff THM, van der Marel GA, Overhand M, van Boom JH, Valentijn ARPM & Overkleeft HS (2003), Synthesis of novel tetrahydropyran-based dipeptide isosters by Overman rearrangement of 2,3-didehydroglycosides, European Journal of Organic Chemistry.
- Koscielniak E, de Boer T, Dupuis S, Naumann L, Casanova JL & Ottenhoff THM (2003), Disseminated Mycobacterium peregrinum infection in a child with complete interferon-gamma receptor-1 deficiency, Pediatric Infectious Disease Journal 22(4).
- Skjot RLV, Brock I, Arend SM, Munk ME, Theisen M, Ottenhoff THM & Andersen P (2002), Epitope mapping of the immunodominant antigen TB10.4 and the two homologous proteins TB10.3 and TB12.9, which constitute a subfamily of the esat-6 gene family, Infection and Immunity 70(10).
- Cardoso FLL, Antas PRZ, Milagres AS, Geluk A, Franken KLMC, Oliveira EB, Teixeira HC, Nogueira SA, Sarno EN, Klatser P, Ottenhoff THM & Sampaio EP (2002), T-cell responses to the Mycobacterium tuberculosis- specific antigen ESAT-6 in Brazilian tuberculosis patients, Infection and Immunity 70(12).
- Arend SM, van Meijgaarden KE, de Boer K, de Palou EC, van Soolingen D, Ottenhoff THM & van Dissel JT (2002), Tuberculin skin testing and in vitro T cell responses to ESAT-6 and culture filtrate protein 10 after infection with Mycobacterium marinum or M-kansasii, Journal of Infectious Diseases 186(12).
- Ottenhoff THM, Verreck FAW, Lichtenauer-Kaligis EGR, Hoeve MA, Sanal O & van Dissel JT (2002), Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae, Nature Genetics 32(1).
- Ottenhoff THM (2002), Mycobacterium leprae and demyelination, Science 297(5586).
- Brahmbhatt S, Hussain R, Zafar S, Dawood G, Ottenhoff THM, Drijfhout JW, Bothamley G, Smith S, Lopez FV & Dockrell HM (2002), Human T cell responses to peptides of the Mycobacterium leprae 45-kD serine-rich antigen, Clinical and Experimental Immunology 128(1).
- Geluk A, Ottenhoff THM, Arend SM, Andersen P & Doherty TM (2002), ESAT-6 and CFP-10: What is the diagnosis? Authors' reply, Infection and Immunity 70(11).
- Verreck FAW, de Boer T, Hoeve M, van Dissel JT, Sanal O, Kurimoto M & Ottenhoff THM (2002), Human host defense and cytokines in mycobacterial infectious diseases: Interleukin-18 cannot compensate for genetic defects in the interleukin-12 system, Clinical Infectious Diseases 35(2).
- Santos AR, Suffys PN, Vanderborght PR, Moraes MO, Vieira LMM, Cabello PH, Bakker AM, Matos HJ, Huizinga TWJ, Ottenhoff THM, Sampaio EP & Sarno EN (2002), Role of tumor necrosis factor-alpha and interleukin-10 promoter gene polymorphisms in leprosy, Journal of Infectious Diseases 186(11).
- Lammas DA, De Heer E, Edgar JD, Novelli V, Ben-Smith A, Baretto R, Drysdale P, Binch J, MacLennan C, Kumararatne DS, Panchalingam S, Ottenhoff THM, Casanova JL & Emile JF (2002), Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production pathway, International Journal of Experimental Pathology 83(1).
- Geluk, A.; Meijgaarden, K.E. van; Franken, K.L.M.C.; Subronto, Y.W.; Wieles, B.; Arend, S.M.; Sampaio, E.P.; Boer, T. de; Faber, W.R.; Naafs, B. & Ottenhoff, T.H.M. (2002), Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis, Infection and Immunity 70(5).
- van Crevel R, Ottenhoff THM & van der Meer JWM (2002), Innate immunity to Mycobacterium tuberculosis, Clinical Microbiology Reviews 15(2).
- Janssen R, van Wengen A, Verhard E, de Boer T, Zomerdijk T, Ottenhoff THM & van Dissel JT (2002), Divergent role for TNF-alpha in IFN-gamma-induced killing of Toxoplasma gondii and Salmonella typhimurium contributes to selective susceptibility of patients with partial IFN-gamma receptor 1 deficiency, Journal of Immunology 169(7).
- Schuller S, Neefjes J, Ottenhoff T, Thole J & Young D (2001), Coronin is involved in uptake of Mycobacterium bovis BCG in human macrophages but not in phagosome maintenance, Cellular Microbiology 3(12).
- Munk ME, Arend SM, Brock I, Ottenhoff THM & Andersen P (2001), Use of ESAT-6 and CFP-10 antigens for diagnosis of extrapulmonary tuberculosis, Journal of Infectious Diseases 183(1).
- van der Burg SH, Ressing ME, Kwappenberg KMC, de Jong A, Straathof K, de Jong J, Geluk A, van Meijgaarden KE, Franken KLMC, Ottenhoff THM, Fleuren GJ, Kenter G, Melief CJM & Offringa R (2001), Natural T-HELPER immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: Identification of 3 human leukocyte antigen class II-restricted epitopes, International Journal of Cancer 91(5).
- Arend SM, van Soolingen D, Ottenhoff THM & van Dissel JT (2001), Repeatedly negative tuberculin skin tests followed by active tuberculosis in an immunocompetent individual, Netherlands Journal of Medicine 58(2).
- Tanghe A, D'Souza S, Rosseels V, Denis O, Ottenhoff THM, Dalemans W, Wheeler C & Huygen K (2001), Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting, Infection and Immunity 69(5).
- Macfarlane A, Mondragon-Gonzalez R, Vega-Lopez F, Wieles B, de Pena J, Rodriguez O, de la Torre RS, de Vries RRP, Ottenhoff THM & Dockrell HM (2001), Presence of human T-cell responses to the Mycobacterium leprae 45-kilodalton antigen reflects infection with or exposure to M-leprae, Clinical and Diagnostic Laboratory Immunology 8(3).
- Arend SM, Ottenhoff THM, Andersen P & van Dissel JT (2001), Uncommon presentations of tuberculosis: the potential value of a novel diagnostic assay based on the Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10, International Journal of Tuberculosis and Lung Disease 5(7).
- Spierings E, de Boer T, Wieles B, Adams LB, Marani E & Ottenhoff THM (2001), Mycobacterium leprae-specific, HLA class II-restricted killing of human Schwann cells by CD4(+) Th1 cells: A novel immunopathogenic mechanism of nerve damage in leprosy, Journal of Immunology 166(10).
- Charo J, Sundback M, Geluk A, Ottenhoff T & Kiessling R (2001), DNA immunization of HLA transgenic mice with a plasmid expressing mycobacterial heat shock protein 65 results in HLA class I- and II-restricted T cell responses that can be augmented by cytokines, Human Gene Therapy 12(14).
- van Dissel JT, Arend SM & Ottenhoff THM (2001), Infections with non-tuberculous mycobacteria and salmonellae in patients with genetic defects in the interleukin-12/interferon-gamma-mediated pathway of macrophage activation, Netherlands Journal of Medicine 59(3).
- Arend SM, Janssen R, Gosen JJ, Waanders H, de Boer T, Ottenhoff THM & van Dissel JT (2001), Multifocal osteomyelitis caused by nontuberculous mycobacteria in patients with a genetic defect of the interferon-gamma receptor, Netherlands Journal of Medicine 59(3).
- Charo J, Geluk A, Sundback M, Mirzai B, Diehl AD, Malmberg KJ, Achour A, Huriguchi S, van Meijgaarden KE, Drijfhout JW, Beekman N, van Veelen P, Ossendorp F, Ottenhoff THM & Kiessling R (2001), The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65, European Journal of Immunology 31(12).
- Arend SM, Engelhard ACF, Groot G, de Boer K, Andersen P, Ottenhoff THW & van Dissel JT (2001), Tuberculin skin testing compared with T-cell responses to Mycobacterium tuberculosis-specific and nonspecific antigens for detection of latent infection in persons with recent tuberculosis contact, Clinical and Diagnostic Laboratory Immunology 8(6).
- Arend SM, Andersen P, van Meijgaarden KE, Skjot RLV, Subronto YW, van Dissel JT & Ottenhoff THM (2000), Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10.
- Arend SM, Geluk A, van Meijgaarden KE, van Dissel JT, Theisen M, Andersen P & Ottenhoff THM (2000), Antigenic equivalence of human T-cell responses to Mycobacterium tuberculosis-specific RD1-encoded protein antigens ESAT-6 and culture filtrate protein 10 and to mixtures of synthetic peptides.
- Geluk, A.; Meijgaarden, K.E. van; Franken, K.L.M.C.; Drijfhout, J.W.; D'Souza, S.; Necker, A.; Huygen, K. & Ottenhoff, T.H.M. (2000), Identification of major epitopes of Mycobacterium tuberculosis AG85B that are recognized by HLA-A*0201-restricted CD8(+) T cells in HLA-transgenic mice and humans, Journal of Immunology 165(11).
- Rea D, van Kooten C, van Meijgaarden KE, Ottenhoff THM, Melief CJM & Offringa R (2000), Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10.
- Ottenhoff THM, de Boer T, Verhagen CE, Verreck FAW & van Dissel JT (2000), Human deficiencies in type 1 cytokine receptors reveal the essential role of type 1 cytokines in immunity to intracellular bacteria, Microbes and Infection 2(13).
- van Ham M, van Lith M, Lillemeier B, Tjin E, Gruneberg U, Rahman D, Pastoors L, van Meijgaarden K, Roucard C, Trowsdale J, Ottenhoff T, Pappin D & Neefjes J (2000), Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO.
- Vos K, Miltenburg AMM, van Meijgaarden KE, van den Heuvel M, Elferink DG, van Galen PJM, van Hogezand RA, van Vliet-Daskalopoulou E, Ottenhoff THM, Breedveld FC, Boots AMH & de Vries RRP (2000), Cellular immune response to human cartilage glycoprotein-39 (HC gp-39)-derived peptides in rheumatoid arthritis and other inflammatory conditions, Rheumatology 39(12).
- Spierings E, De Boer T, Zulianello L & Ottenhoff THM (2000), Novel mechanisms in the immunopathogenesis of leprosy nerve damage: The role of Schwann cells, T cells and Mycobacterium leprae.
- Verhagen CE, de Boer T, Smits HH, Verreck FAW, Wierenga EA, Kurimoto M, Lammas DA, Kumararatne DS, Sanal O, Kroon FP, van Dissel JT, Sinigaglia F & Ottenhoff THM (2000), Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta 1 (IL-12R beta 1): Evidence for an IL-12R beta 1-independent pathway of IL-12 responsiveness in human T cells.
- Spierings E, Vleggeert-Lankamp CLAM, Marani E, Thomeer RTWM & Ottenhoff THM (2000), Allorecognition of artificial nerve guides filled with human Schwann cells - An in vitro pilot study.
- Franken KLMC, Hiemstra HS, van Meijgaarden KE, Subronto Y, den Hartigh J, Ottenhoff THM & Drijfhout JW (2000), Purification of His-tagged proteins by immobilized chelate affinity chromatography: The benefits from the use of organic solvent.
- Spierings E, De Boer T, Zulianello L & Ottenhoff THM (2000), The role of Schwann cells, T cells and Mycobacterium leprae in the immunopathogenesis of nerve damage in leprosy, Leprosy Review 71.
- Hiemstra HS, van Veelen PA, Geluk A, Schloot NC, de Vries RRP, Ottenhoff THM, Roep BO & Drijfhout JW (1999), Limitations of homology searching for identification of T-cell antigens with library derived mimicry epitopes, Vaccine 18(3-4): 204-208.
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- Hiemstra HS, van Veelen PA, Schloot NC, Geluk A, van Meijgaarden KE, Willemen SJM, Leunissen JAM, Benckhuijsen WE, Amons R, de Vries RRP, Roep BO, Ottenhoff THM & Drijfhout JW (1998), Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries, Journal of Immunology 161(8): 4078-4082.
- Mr. Horizon2020
- Member Board ‘s-Gravenhaagse
- Permanent Senior Management Team Member
- Member
- Member Editorial Board
- Member
- Member Editorial Board
- Member of the Steering Committee
- Member review panel
- permanent member
- Member Editorial Board
- Member
- Member of the Foundation Board