Sjoerd van der Burg
Full professor
- Name
- Prof.dr. S.H. van der Burg
- Telephone
- +31 71 526 1180
- s.h.van_der_burg@lumc.nl
- ORCID iD
- 0000-0002-6556-0354
Sjoerd van der Burg is full professor in the Immunotherapy of solid tumors with emphasis on immunomonitoring. He heads the laboratory of Medical Oncology and leads the group of Experimental Cancer Immunology and Therapy. He is also appointed as senior investigator at the Oncode Institute. In addition, he is appointed as member of the management team of the research profile area Cancer Pathogenesis and Therapy.
More information about Sjoerd van der Burg
See also
The immune system and tumors
The immune system plays an essential but dual role in the development of cancer. Studies on the interaction between tumors and the immune system both in animal models as in patients with (pre-)cancers result in a better understanding on the role of different components of the immune system which may foster tumor growth or prevent it. An improved insight is the basis for the development of several forms of immunotherapy, aiming to reinforce tumor-reactive immunity as treatment for cancer. This work makes an important contribution to answer cluster questions 85, 96 and 99 of the Dutch National Research Agenda.
Academic career
Van der Burg received his PhD on April 1, 1998 for his thesis on the Identification and evaluation of cytotoxic T-cell epitopes in HIV-1 and tumour associated proteins, from the Leiden University.
In 2003 he was appointed as staff member (LUMC) end assistant professor (Leiden University) at the department of Immunohematology and Blood Transfusion.
In 2006 he was appointed as staff member (LUMC) and associate professor (Leiden University) and leader of the group Experimental cancer immunology and therapy at the department of Medical Oncology, LUMC
In 2010 he was promoted to full professor at the department of Medical Oncology, LUMC. He gave his public speech “Op zoek naar een éénarmige immunoloog” on May 9, 2011.
In 2019 he was also appointed as Senior Investigator at the Oncode Institute.
Full professor
- Faculteit Geneeskunde
- Divisie 4
- Klinische Oncologie
- Klinische Oncologie algemeen
- Poelgeest, M.I.E. van; Kortekaas, K.E.; Doorn, H.C. van; Oonk, M.; Nijman, H.W.; Boere, I.; Eerkens, A.L.; Reyners, A.; Ewing-Graham, P.C.; Bart, J.; Welters, M.J.P.; Bosse, T.; Kroep, J.R. & Burg, S.H. van der (2024), APOLLO: neo-adjuvant pembrolizumab for primary vulvar squamous cell carcinoma, International Journal of Gynecological Cancer.
- Lei, X.; Groot, D.C. de; Welters, M.J.P.; Wit, T. de; Schrama, E.; Eenennaam, H. van; Santegoets, S.J.; Oosenbrug, T.; Veen, A. van der; Vos, J.L.; Zuur, C.L.; Miranda, N.F.C.C. de; Jacobs, H.; Burg, S.H. van der; Borst, J. & Xiao, Y.L. (2024), CD4+T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors, Cellular & Molecular Immunology.
- Santegoets, S.J.; Stolk, A.; Welters, M.J.P. & Burg, S.H. van der (2023), The combined HPV16-E2/E6/E7 T cell response in oropharyngeal cancer predicts superior survival, Cell Reports Medicine 4(11).
- Eijck, C.W.F. van; Koning, W. de; Sijde, F. van der; Moskie, M.; Koerkamp, B.G.; Homs, M.Y.V.; Burg, S.H. van der; Eijck, C.H.J. van & Mustafa, D.A.M. (2023), A multigene circulating biomarker to predict the lack of FOLFIRINOX response after a single cycle in patients with pancreatic ductal adenocarcinoma, European Journal of Cancer 181: 119-134.
- Verdegaal, E.M.E.; Santegoets, S.J.; Welters, M.J.P.; Bruin, L. de; Visser, M.; Minne, C.E. van der; Kok, P.M. de; Loof, N.M.; Boekestijn, S.; Roozen, I.; Westra, I.M.; Meij, P.; Burg, S.H. van der & Kroep, J.R. (2023), Timed adoptive T cell transfer during chemotherapy in patients with recurrent platinum-sensitive epithelial ovarian cancer, Journal for ImmunoTherapy of Cancer 11(11).
- Middelburg, J.; Ghaffari, S.; Schoufour, T.A.W.; Sluijter, M.; Schaap, G.; Göynük, B.; Sala, B.M.; Al-Tamimi, L.; Scheeren, F.; Franken, K.L.M.C.; Akkermans, J.J.L.L.; Cabukusta, B.; Joosten, S.A.; Derksen, I.; Neefjes, J.; Burg, S.H. van der; Achour, A.; Wijdeven, R.H.M.; Weidanz, J. & Hall, T. van (2023), The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent, Cell Reports 42(12).
- Gulijk, M. van; Krimpen, A. van; Schetters, S.; Eterman, M.; Elsas, M. van; Mankor, J.; Klaase, L.; Bruijn, M. de; Nimwegen, M. van; Tienhoven, T. van; Ijcken, W. van; Boon, L.; Schoot, J. van der; Verdoes, M.; Scheeren, F.; Burg, S.H. van der; Lambrecht, B.N.; Stadhouders, R.; Dammeijer, F.; Aerts, J. & Hall, T. van (2023), PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance, Science Immunology 8(83).
- Lybaert, L.; Thielemans, K.; Feldman, S.A.; Burg, S.H. van der; Bogaert, C. & Ott, P.A. (2023), Neoantigen-directed therapeutics in the clinic: where are we?, TRENDS IN CANCER 98(6): 503-519.
- Groeneveldt, C.; Ginkel, J.Q.; Kinderman, P.; Sluijter, M.; Griffioen, L.; Labrie, C.; Wollenberg, D.J.M. van den; Hoeben, R.C.; Burg, S.H. van der; Dijke, P. ten; Hawinkels, L.J.A.C.; Hall, T. van & Montfoort, N. van (2023), Intertumoral differences dictate the outcome of TGF-β blockade on the efficacy of viro-immunotherapy, Cancer Research Communications 3(2): 325-337.
- Eijck, C.W.F. van; Mustafa, D.A.M.; Vadgama, D.; Miranda, N.F.C.C. de; Koerkamp, B.G.; Tienhoven, G. van; Burg, S.H. van der; Malats, N.; Eijck, C.H.J. van & Dutch Pancreatic Canc Grp DPCG (2023), Enhanced antitumour immunity following neoadjuvant chemoradiotherapy mediates a favourable prognosis in women with resected pancreatic cancer, Gut 73.
- Lybaert, L.; Lefever, S.; Fant, B.; Smits, E.; Geest, B. de; Breckpot, K.; Dirix, L.; Feldman, S.A.; Criekinge, W. van; Thielemans, K.; Burg, S.H. van der; Ott, P.A. & Bogaert, C. (2023), Challenges in neoantigen-directed therapeutics, Cancer Cell 41(1): 15-40.
- Haake, M.; Haack, B.; Schäfer, T.; Harter, P.N.; Mattavelli, G.; Eiring, P.; Vashist, N.; Wedekink, F.; Genssler, S.; Fischer, B.; Dahlhoff, J.; Mokhtari, F.; Kuzkina, A.; Welters, M.J.P.; Benz, T.M.; Sorger, L.; Thiemann, V.; Almanzar, G.; Selle, M.; Thein, K.; Späth, J.; Gonzalez, M.C.; Reitinger, C.; Ipsen-Escobedo, A.; Wistuba-Hamprecht, K.; Eichler, K.; Filipski, K.; Zeiner, P.S.; Beschorner, R.; Goedemans, R.; Gogolla, F.H.; Hackl, H.; Rooswinkel, R.W.; Thiem, A.; Roche, P.R.; Joshi, H.; Pühringer, D.; Wöckel, A.; Diessner, J.E.; Rüdiger, M.; Leo, E.; Cheng, P.F.; Levesque, M.P.; Goebeler, M.; Sauer, M.; Nimmerjahn, F.; Schuberth-Wagner, C.; Felten, S. von; Mittelbronn, M.; Mehling, M.; Beilhack, A.; Burg, S.H. van der; Riedel, A.; Weide, B.; Dummer, R. & Wischhusen, J. (2023), Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment, Nature Communications 14(1).
- Elsas, M.J. van; Labrie, C.; Etzerodt, A.; Charoentong, P.; Thans, J.J.C.V.; Hall, T. van & Burg, S.H. van der (2023), Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy, Journal for ImmunoTherapy of Cancer 11(3).
- Bulk, J. van den; Ploeg, M. van der; Ijsselsteijn, M.E.; Ruano, D.; Breggen, R. van der; Duhen, R.; Peeters, K.C.M.J.; Farina-Sarasqueta, A.; Verdegaal, E.M.E.; Burg, S.H. van der; Duhen, T. & Miranda, N.F.C.C. de (2023), CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden, Journal for ImmunoTherapy of Cancer 11(2).
- Abdulrahman, Z.; Santegoets, S.J.; Sturm, G.; Charoentong, P.; Ijsselsteijn, M.E.; Somarakis, A.; Hollt, T.; Finotello, F.; Trajanoski, Z.; Egmond, S.L. van; Mustafa, D.A.M.; Welters, M.J.P.; Miranda, N.F.C.C. de & Burg, S.H. van der (2022), Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival, Journal for ImmunoTherapy of Cancer 10(2).
- Lau, S.P.; Land, F.R. van 't; Burg, S.H. van der; Homs, M.Y.V.; Lolkema, M.P.; Aerts, J.G.J.V. & Eijck, C.H.J. van (2022), Safety and tumour-specific immunological responses of combined dendritic cell vaccination and anti-CD40 agonistic antibody treatment for patients with metastatic pancreatic cancer, BMJ Open 12(6).
- Groeneveldt, C.; Kinderman, P.; Thans, J.J.C.V.; Labrie, C.; Griffioen, L.; Sluijter, M.; Wollenberg, D.J.M. van den; Hoeben, R.C.; Haan, J.M.M. den; Burg, S.H. van der; Hall, T. van & Montfoort, N. van (2022), Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy, United European Gastroenterology Journal 10.
- Elsas, M.J. van; Schoot, J.M.S. van der; Bartels, A.; Steuten, K.; Dalen, D. van; Wijfjes, Z.; Figdor, C.G.; Hall, T. van; Burg, S.H. van der; Verdoes, M. & Scheeren, F.A. (2022), Regulatory T Cell Depletion Using a CRISPR Fc-Optimized CD25 Antibody, International Journal of Molecular Sciences 23(15).
- Lau, S.P.; Land, F.R. van 't; Burg, S.H. van der; Homs, M.Y.V.; Lolkema, M.P.; Aerts, J.G.J.V. & Eijck, C.H.J. van (2022), Safety and tumour-specific immunological responses of combined dendritic cell vaccination and anti-CD40 agonistic antibody treatment for patients with metastatic pancreatic cancer, BMJ Open 12(6).
- Speetjens, F.M.; Welters, M.J.P.; Slingerland, M.; Poelgeest, M.I.E. van; Steenwijk, P.J.D. van; Roozen, I.; Boekestijn, S.; Loof, N.M.; Zom, G.G.; Valentijn, A.R.P.M.; Krebber, W.J.; Meeuwenoord, N.J.; Janssen, C.A.H.; Melief, C.J.M.; Marel, G.A. van der; Filippov, D.V.; Burg, S.H. van der; Gelderblom, H. & Ossendorp, F. (2022), Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions, Journal for ImmunoTherapy of Cancer 10(10).
- Abdulrahman, Z.; Hendriks, N.; Kruse, A.J.; Somarakis, A.; Sande, A.J.M. van de; Beekhuizen, H.J. van; Piek, J.M.J.; Miranda, N.F.C.C. de; Kooreman, L.F.S.; Slangen, B.F.M.; Burg, S.H. van der; Steenwijk, P.J.D. van & Esch, E.M.G. van (2022), Immune-based biomarker accurately predicts response to imiquimod immunotherapy in cervical high-grade squamous intraepithelial lesions, Journal for ImmunoTherapy of Cancer 10(11).
- Gruil, N. de; Pijl, H.; Burg, S.H. van der & Kroep, J.R. (2022), Short-term fasting synergizes with solid cancer therapy by boosting antitumor immunity, Cancers 14(6).
- Santegoets, S.J.; Welters, M.J.P.; Schrikkema, D.S.; Freriks, M.R.; Kok, H.; Weissbrich, B.; Branden, A. van den; Linnemann, C.; Schumacher, T.N.; Adhikary, S.; Bendle, G. & Burg, S.H. van der (2022), The common HLA class I-restricted tumor-infiltrating T cell response in HPV16-induced cancer, Cancer Immunology, Immunotherapy 72.
- Gezgin, G.; Visser, M.; Ruano, D.; Santegoets, S.J.; Miranda, N.F.C.C. de; Velden, P.A. van der; Luyten, G.P.M.; Burg, S.H. van der; Verdegaal, E.M. & Jager, M.J. (2022), Tumor-infiltrating T cells can be expanded successfully from primary uveal melanoma after separation from their tumor environment, OPHTHALMOLOGY SCIENCE 2(2).
- Borst, L.; Sluijter, M.; Sturm, G.; Charoentong, P.; Santegoets, S.J.; Gulijk, M.; Elsas, M.J. van; Groeneveldt, C.; Montfoort, N. van; Finotello, F.; Trajanoski, Z.; Kielbasa, S.M.; Burg, S.H. van der & Hall, T. van (2022), NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division, International Journal of Cancer 150(4): 688-704.
- Duurland, C.L.; Santegoets, S.J.; Abdulrahman, Z.; Loof, N.M.; Sturm, G.; Wesselink, T.H.; Arens, R.; Boekestijn, S.; Ehsan, I.; Poelgeest, M.I.E. van; Finotello, F.; Hackl, H.; Trajanoski, Z.; Dijke, P. ten; Braud, V.M.; Welters, M.J.P. & Burg, S.H. van der (2022), CD161 expression and regulation defines rapidly responding effector CD4+T cells associated with improved survival in HPV16-associated tumors, Journal for ImmunoTherapy of Cancer 10(1).
- Wu, S.D.; Rietveld, M.; Hogervorst, M.; Gruijl, F. de; Burg, S. van der; Vermeer, M.; Doorn, R. van; Welters, M. & Ghalbzouri, A. el (2022), Human papillary and reticular fibroblasts show distinct functions on tumor behavior in 3D-organotypic cultures mimicking melanoma and HNSCC, International Journal of Molecular Sciences 23(19).
- Harryvan, T.J.; Visser, M.; Bruin, L. de; Plug, L.; Griffioen, L.; Mulder, A.; Veelen, P.A. van; Noort, G.J.V. van; Jongsma, M.L.; Meeuwsen, M.H.; Wiertz, E.J.; Santegoets, S.J.; Hardwick, J.C.; Hall, T. van; Neefjes, J.; Burg, S.H. van der; Hawinkels, L.J.A.C. & Verdegaal, E.M.E. (2022), Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S, Journal for ImmunoTherapy of Cancer 10(3).
- Cuburu, N.; Finn, O.J. & Burg, S.H. van der (2022), Editorial: Cancer Prevention: Targeting Premalignant Epithelial Neoplasms in the Era of Cancer Immunotherapy and Vaccines, Frontiers in Immunology 13.
- Stingl, C.; Lau, S.P.; Burg, S.H. van der; Aerts, J.G.; Eijck, C.H.J. van & Luider, T.M. (2022), Dataset from a proteomics analysis of tumor antigens shared between an allogenic tumor cell lysate vaccine and pancreatic tumor tissue., Data in Brief 44.
- Duijn, A. van; Burg, S.H. van der & Scheeren, F.A. (2022), CD47/SIRPα axis: bridging innate and adaptive immunity, Journal for ImmunoTherapy of Cancer 10(7).
- Pasmans, H.; Berkowska, M.A.; Diks, A.M.; Mooij, B. de; Groenland, R.J.; Rond, L. de; Nicolaie, M.A.; Burg, S.H. van der; Dongen, J.J.M. van; Klis, F.R.M. van der & Buisman, A.M. (2022), Characterization of the early cellular immune response induced by HPV vaccines, Frontiers in Immunology 13.
- Duijn, A. van; Burg, S.H. van der & Scheeren, F.A. (2022), CD47/SIRP alpha axis: bridging innate and adaptive immunity, Journal for ImmunoTherapy of Cancer 10(7).
- Paaso, A.; Koskimaa, H.M.; Welters, M.J.P.; Kero, K.; Rautava, J.; Syrjanen, K.; Burg, S.H. van der & Syrjanen, S. (2021), Interferon-gamma and IL-5 associated cell-mediated immune responses to HPV16 E2 and E6 distinguish between persistent oral HPV16 infections and noninfected mucosa, Clinical and Experimental Dental Research 7(5).
- Saxena, M.; Burg, S.H. van der; Melief, C.J.M. & Bhardwaj, N. (2021), Therapeutic cancer vaccines, Nature Reviews Cancer 21(6): 360-378.
- Otterhaug, T.; Janetzki, S.; Welters, M.J.P.; Hakerud, M.; Nedberg, A.G.; Edwards, V.T.; Boekestijn, S.; Loof, N.M.; Selbo, P.K.; Olivecrona, H.; Burg, S.H. van der & Hogset, A. (2021), Photochemical internalization enhanced vaccination is safe, and gives promising cellular immune responses to an HPV peptide-based vaccine in a phase I clinical study in healthy volunteers, Frontiers in Immunology 11.
- Marijt, K.A.; Griffioen, L.; Blijleven, L.; Burg, S.H. van der & Hall, T. van (2021), Cross-presentation of a TAP-independent signal peptide induces CD8 T immunity to escaped cancers but necessitates anchor replacement, Cancer Immunology, Immunotherapy 71.
- Melssen, M.M.; Lindsay, R.S.; Stasiak, K.; Rodriguez, A.B.; Briegel, A.M.; Cyranowski, S.; Rutkowski, M.R.; Conaway, M.R.; Melief, C.J.M.; Burg, S.H. van der; Eyo, U.; Slingluff, C.L. & Engelhard, V.H. (2021), Differential expression of CD49a and CD49b determines localization and function of tumor-infiltrating CD8(+) T cells, Cancer Immunology Research 9(5): 583-597.
- Nejad, E.B.; Labrie, C.; Elsas, M.J. van; Kleinovink, J.W.; Mittrucker, H.W.; Franken, K.L.M.C.; Heink, S.; Korn, T.; Arens, R.; Hall, T. van & Burg, S.H. van der (2021), IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors, Journal for ImmunoTherapy of Cancer 9(4).
- Burg, S.H. van der (2021), IL11: A Specific Repressor of Tumor-Specific CD4(+) T Cells, Cancer Immunology Research 9(7): 724-724.
- Corbeau, A.; Nout, R.A.; Mens, J.W.M.; Horeweg, N.; Godart, J.; Kerkhof, E.M.; Kuipers, S.C.; Poelgeest, M.I.E. van; Kroep, J.R.; Boere, I.A.; Doorn, H.C. van; Hoogeman, M.S.; Heide, U.A. van der; Putter, H.; Welters, M.J.P.; Burg, S.H. van der; Creutzberg, C.L. & Boer, S.M. de (2021), PROTECT: prospective phase-II-trial evaluating adaptive proton therapy for cervical cancer to reduce the impact on morbidity and the immune system, Cancers 13(20).
- Kortekaas, K.E.; Santegoets, S.J.; Tas, L.; Ehsan, I.; Charoentong, P.; Doorn, H.C. van; Poelgeest, M.I.E. van; Mustafa, D.A.M. & Burg, S.H. van der (2021), Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy, Journal for ImmunoTherapy of Cancer 9(10).
- Baltussen, J.C.; Welters, M.J.P.; Verdegaal, E.M.E.; Kapiteijn, E.; Schrader, A.M.R.; Slingerland, M.; Liefers, G.J.; Burg, S.H. van der; Portielje, J.E.A. & Glas, N.A. de (2021), Predictive biomarkers for outcomes of immune checkpoint inhibitors (ICIs) in melanoma: a systematic review, Cancers 13(24).
- Verdegaal, E.; Kooij, M.K. van der; Visser, M.; Minne, C. van der; Bruin, L. de; Meij, P.; Scheltinga, A.T. van; Welters, M.J.; Santegoets, S.; Miranda, N. de; Roozen, I.; Liefers, G.J.; Kapiteijn, E. & Burg, S.H. van der (2020), Low-dose interferon-alpha preconditioning and adoptive cell therapy in patients with metastatic melanoma refractory to standard (immune) therapies, Journal for ImmunoTherapy of Cancer 8(1).
- Groeneveldt, C.; Kinderman, P.; Wollenberg, D.J.M. van den; Oever, R.L. van den; Middelburg, J.; Mustafa, D.A.M.; Hoeben, R.C.; Burg, S.H. van der; Hall, T. van & Montfoort, N. van (2020), Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy, Journal for ImmunoTherapy of Cancer 8(2).
- Kortekaas, K.E.; Bastiaannet, E.; Doorn, H.C. van; Steenwijk, P.J.D. van; Ewing-Graham, P.C.; Creutzberg, C.L.; Akdeniz, K.; Nooij, L.S.; Burg, S.H. van der; Bosse, T. & Poelgeest, M.I.E. van (2020), Vulvar cancer subclassification by HPV and p53 status results in three clinically distinct subtypes, Gynecologic Oncology 159(3): 649-656.
- Welters, M.J.P.; Santegoets, S.J. & Burg, S.H. van der (2020), The tumor microenvironment and immunotherapy of oropharyngeal squamous cell carcinoma, Frontiers in Oncology 10.
- Ende, T.C. van den; Heuts, J.M.M.; Gential, G.P.P.; Visser, M.; Graaff, M.J. van de; Ho, N.I.; Jiskoot, W.; Valentijn, A.R.P.M.; Meeuwenoord, N.J.; Overkleeft, H.S.; Codee, J.D.C.; Burg, S.H. van der; Verdegaal, E.M.E.; Marel, G.A. van der; Ossendorp, F. & Filippov, D.V. (2020), Simplified monopalmitoyl toll-like receptor 2 ligand mini-U pam for self-adjuvanting neoantigen-based synthetic cancer vaccines, ChemBioChem 22(7).
- Kooij, M.K. van der; Verdegaal, E.M.E.; Visser, M.; Bruin, L. de; Minne, C.E. van der; Meij, P.M.; Roozen, I.C.F.M.; Jonker, M.A.; Bosch, S. van den; Liefers, G.J.; Speetjens, F.M.; Burg, S.H. van der & Kapiteijn, E. (2020), Phase I/II study protocol to assess safety and efficacy of adoptive cell therapy with anti-PD-1 plus low-dose pegylated-interferon-alpha in patients with metastatic melanoma refractory to standard of care treatments: the ACTME trial, BMJ Open 10(11).
- Hurkmans, D.P.; Verdegaal, E.M.E.; Hogan, S.A.; Wijn, R. de; Hovestad, L.; Heuvel, D.M.A. van den; Ruijtenbeek, R.; Welters, M.J.P.; Brakel, M. van; Basak, E.A.; Pinedo, H.M.; Lamers, C.H.J.; Werken, H.J.G. van de; Groten, J.P.; Debets, R.; Levesque, M.P.; Dummer, R.; Kapiteijn, E.; Mathijssen, R.H.J.; Aerts, J.G.J.V. & Burg, S.H. van der (2020), Blood-based kinase activity profiling, Journal for ImmunoTherapy of Cancer 8(2).
- Borst, L.; Burg, S.H. van der & Hall, T. van (2020), The NKG2A-HLA-E Axis as a Novel Checkpoint in the Tumor Microenvironment, Clinical Cancer Research 26(21): 5549-5556.
- Jong, G. de; Bartels, L.; Kedde, M.; Verdegaal, E.M.E.; Gillissen, M.A.; Levie, S.E.; Cercel, M.G.; Hal-van Veen, S.E. van; Fatmawati, C.; Berg, D. van de; Yasuda, E.; Claassen, Y.B.; Bakker, A.Q.; Burg, S.H. van der; Schotte, R.; Villaudy, J.; Spits, H.; Hazenberg, M.D.; Helden, P.M. van & Wagner, K. (2020), Melanoma cells can be eliminated by sialylated CD43 x CD3 bispecific T cell engager formats in vitro and in vivo, Cancer Immunology, Immunotherapy.
- Nejad, E.B.; Labrie, C.; Abdulrahman, Z.; Elsas, M.J. van; Rademaker, E.; Kleinovink, J.W.; Sluis, T.C. van der; Duikeren, S. van; Teunisse, A.F.A.S.; Jochemsen, A.G.; Oosting, J.; Miranda, N.F.C.C. de; Hall, T. van; Arens, R. & Burg, S.H. van der (2020), Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy, Journal for ImmunoTherapy of Cancer 8(2).
- Elsas, M. van; Kleinovink, J.W.; Moerland, M.; Feiss, G.; Beyrend, G.; Arens, R.; Mei, H.L.; Nibbering, P.H.; Jirka, S.M.; Hall, T. van & Burg, S.H. van der (2020), Host genetics and tumor environment determine the functional impact of neutrophils in mouse tumor models, Journal for ImmunoTherapy of Cancer 8(2).
- Kortekaas, K.E.; Santegoets, S.J.; Sturm, G.; Ehsan, I.; Egmond, S.L. van; Finotello, F.; Trajanoski, Z.; Welters, M.J.P.; Poelgeest, M.I.E. van & Burg, S.H. van der (2020), CD39 Identifies the CD4(+) Tumor-Specific T-cell Population in Human Cancer, Cancer Immunology Research 8(10): 1311-1321.
- Hurkmans, D.P.; Kuipers, M.E.; Smit, J.; Marion, R. van; Mathijssen, R.H.J.; Postmus, P.E.; Hiemstra, P.S.; Aerts, J.G.J.V.; Thusen, J.H. von der & Burg, S.H. van der (2020), Tumor mutational load, CD8(+) T cells, expression of PD-L1 and HLA class I to guide immunotherapy decisions in NSCLC patients, Cancer Immunology, Immunotherapy 69(5): 771-777.
- Melief, C.J.M.; Welters, M.J.P.; Vergote, I.; Kroep, J.R.; Kenter, G.G.; Ottevanger, P.B.; Tjalma, W.A.A.; Denys, H.; Poelgeest, M.I.E. van; Nijman, H.W.; Reyners, A.K.L.; Velu, T.; Goffin, F.; Lalisang, R.I.; Loof, N.M.; Boekestijn, S.; Krebber, W.J.; Hooftman, L.; Visscher, S.; Blumenstein, B.A.; Stead, R.B.; Gerritsen, W. & Burg, S.H. van der (2020), Strong vaccine responses during chemotherapy are associated with prolonged cancer survival, Science Translational Medicine 12(535).
- Nejad, E.B.; Labrie, C.; Sluis, T.C. van der; Duikeren, S. van; Franken, K.L.M.C.; Roosenhoff, R.; Arens, R.; Hall, T. van & Burg, S.H. van der (2020), Interleukin-6-mediated resistance to immunotherapy is linked to impaired myeloid cell function, International Journal of Cancer 148(1).
- Bidmon, N.; Gouttefangeas, C.; Burg, S.H. van der; Galluzzi, L. & Rudqvist, N.P. (2020), Generation of TCR-engineered reference cell samples to control T-cell assay performance, Methods in Enzymology 631: 195-221.
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- Scholten, K.B.J.; Turksma, A.W.; Ruizendaal, J.J.; Hende, M. van den; Burg, S.H. van der; Heemskerk, M.H.M.; Meijer, C.J.L.M. & Hooijberg, E. (2011), Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer, Journal of Translational Medicine 9.
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- Oliveira, C.C.; Querido, B.; Sluijter, M.; Derbinski, J.; Burg, S.H. van der & Hall, T. van (2011), Peptide transporter TAP mediates between competing antigen sources generating distinct surface MHC class I peptide repertoires, European Journal of Immunology 41(11): 3114-3124.
- Speetjens, F.M.; Zeestraten, E.C.M.; Kuppen, P.J.K.; Melief, C.J.M. & Burg, S.H. van der (2011), Colorectal cancer vaccines in clinical trials, Expert Review of Vaccines 10(6): 899-921.
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- Woo, Y.L.; Hende, M. van den; Sterling, J.C.; Coleman, N.; Crawford, R.A.F.; Kwappenberg, K.M.C.; Stanley, M.A. & Burg, S.H. van der (2010), A prospective study on the natural course of low-grade squamous intraepithelial lesions and the presence of HPV16 E2-, E6-and E7-specific T-cell responses, International Journal of Cancer 126(1): 133-141.
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- Weterings JJ, Khan S, van Noort GJV, Melief CJM, Overkleeft HS, van der Burg SH, Ossendorp F, van der Marel GA & Filippov DV (2009), 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation, Bioorganic and Medicinal Chemistry Letters 19(8): 2249-2251.
- van der Burg SH & Palefsky JM (2009), Human immunodeficiency virus and human papilloma virus - why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful, Journal of Translational Medicine 7.
- Khan S, Weterings JJ, Britten CM, de Jong AR, Graafland D, Melief CJM, van der Burg SH, van der Marel G, Overkleeft HS, Filippov DV & Ossendorp F (2009), Chirality of TLR-2 ligand Pam(3)CysSK(4) in fully synthetic peptide conjugates critically influences the induction of specific CD8(+) T-cells, Molecular Immunology 46(6): 1084-1091.
- Karim R, Jordanova ES, Piersma SJ, Kenter GG, Chen LP, Boer JM, Melief CJM & van der Burg SH (2009), Tumor-Expressed B7-H1 and B7-DC in Relation to PD-1+T-Cell Infiltration and Survival of Patients with Cervical Carcinoma, Clinical Cancer Research 15(20): 6341-6347.
- Speetjens FM, Kuppen PK, Welters MJP, Essahsah F, van den Brink AMEGV, Lantrua MGK, Valentijn ARPM, Oostendorp J, Fathers LM, Nijman HW, Pander J, Drijfhout JW, Van de Velde CJH, Melief CJM & Van der Burg SH (2009), Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer, Clinical Cancer Research 15(3): 1086-1095.
- Lauwen MM, Zwaveling S, de Quartel L, Mota SCF, Grashorn JAC, Melief CJM, van der Burg SH & Offringa R (2008), Self-tolerance does not restrict the CD4+T-helper response against the p53 tumor antigen, Cancer Research 68(3).
- Kenter GG, Welters MJP, Valentijn ARPM, Lowik MJG, Berends-van der Meer DMA, Vloon APG, Drijfhout JW, Wafelman AR, Oostendorp J, Fleuren GJ, Offringa R, van der Burg SH & Melief CJM (2008), Phase I immunotherapeutic trial with long peptides spanning the E6 and E7 sequences of high-risk human papillomavirus 16 in end-stage cervical cancer patients shows lowtoxicity and robust immunogenicity, Clinical Cancer Research 14(1).
- Woo YL, Sterling J, Crawford R, van der Burg SH, Coleman N & Stanley M (2008), FOXP3 immunohistochemistry on formalin-fixed paraffin-embedded tissue: poor correlation between different antibodies, Journal of Clinical Pathology 61(8).
- Welters MJP, Kenter GG, Piersma SJ, Vloon APG, Lowik MJG, Berends-van der Meer DMA, Drijfhout JW, Valentijn ARPM, Wafelman AR, Oostendorp J, Fleuren GJ, Offringa R, Melief CJM & van der Burg SH (2008), Induction of tumor-specific CD4+ and CD8+ T-Cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine, Clinical Cancer Research 14(1).
- Bijker, M.S.; Eeden, S.J.E. van den; Franken, K.L.; Melief, C.J.M.; Burg, S.H. van der & Offringa, R. (2008), Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation, European Journal of Immunology 38(4).
- Melief CJM & van der Burg SH (2008), Immunotherapy of established (pre) malignant disease by synthetic long peptide vaccines, Nature Reviews Cancer 8(5).
- Piersma SJ, Welters MJP & van der Burg SH (2008), Tumor-specific regulatory T cells in cancer patients, Human Immunology 69(4-5).
- van Steenwijk PJD, Piersma SJ, Welters MJP, van der Hulst JM, Fleuren G, Hellebrekers BWJ, Kenter GG & van der Burg SH (2008), Surgery followed by Persistence of High-Grade Squamous Intraepithelial Lesions Is Associated with the Induction of a Dysfunctional HPV16-Specific T-Cell Response, Clinical Cancer Research 14(22).
- Jordanova ES, Gorter A, Ayachi O, Prins F, Durrant LG, Kenter GG, van der Burg SH & Fleuren GJ (2008), Human leukocyte antigen class I, MHC class I chain-related molecule A, and CD8(+)/regulatory T-cell ratio: Which variable determines survival of cervical cancer patients?, Clinical Cancer Research 14(7).
- van den Hende M, van Poelgeest MIE, van der Hulst JM, de Jong J, Drijfhout JW, Fleuren GJ, Valentijn ARPM, Wafelman AR, Slappendel GM, Melief CJM, Offringa R, van der Burg SH & Kenter GG (2008), Skin reactions to human papillomavirus (HPV) 16 specific antigens intradermally injected in healthy subjects and patients with cervical neoplasia, International Journal of Cancer 123(1).
- Britten CM, Gouttefangeas C, Welters MJP, Pawelec G, Koch S, Ottensmeier C, Mander A, Walter S, Paschen A, Muller-Berghaus J, Haas I, Mackensen A, Kollgaard T, Thor Straten P, Schmitt M, Giannopoulos K, Maier R, Veelken H, Bertinetti C, Konur A, Huber C, Stevanovic S, Wolfel T & van der Burg SH (2008), The CIMT-monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8(+) T lymphocytes by structural and functional assays, Cancer Immunology, Immunotherapy 57(3).
- Britten CM, Janetzki S, van der Burg SH, Gouttefangeas C & Hoos A (2008), Toward the harmonization of immune monitoring in clinical trials: Quo vadis?, Cancer Immunology, Immunotherapy 57(3).
- Speetjens FM, Kuppen PJK, Morreau H & van der Burg SH (2008), Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers, Gastroenterology 135(2).
- Welters MJP, Piersma SJ & van der Burg SH (2008), T-regulatory cells in tumour-specific vaccination strategies, Expert Opinion on Biological Therapy 8(9).
- van der Burg SH (2008), Therapeutic vaccines in cancer: moving from immunomonitoring to immunoguiding, Expert Review of Vaccines 7(1).
- Woo YL, Sterling J, Damay I, Coleman N, Crawford R, van der Burg SH & Stanley M (2008), Characterising the local immune responses in cervical intraepithelial neoplasia: a cross-sectional and longitudinal analysis, BJOG: An International Journal of Obstetrics and Gynaecology 115(13).
- Welters, M.J.P.; Bijker, M.S.; Eeden, S.J.F. van den; Franken, K.L.M.C.; Melief, C.J.M.; Offringa, R. & Burg, S.H. van der (2007), Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists, Vaccine 25(8).
- van der Burg SH, Piersma SJ, de Jong A, van der Hulst JM, Kwappenberg KMC, van den Hende M, Welters MJP, Van Rood JJ, Fleuren GJ, Melief CJM, Kenter GG & Offringa R (2007), Association of cervical cancer with the presence of CD4(+) regulatory T cells specific for human papillornavirus antigens, Proceedings of the National Academy of Sciences 104(29).
- Loeser S, Loser K, Bijker MS, Rangachari M, van der Burg SH, Wada T, Beissert S, Melief CJM & Penninger JM (2007), Spontaneous tumor rejection by cbl-b-deficient CD8(+) T cells, Journal of Experimental Medicine 204(4).
- de Boer MA, Jordanova ES, van Poelgeest MIE, van den Akker BE, van der Burg SH, Kenter GG & Fleuren GJ (2007), Circulating human papillomavirus Type 16 specific T-cells are associated with HLA Class I expression on tumor cells, but not related to the amount of viral oncogene transcripts, International Journal of Cancer 121(12).
- Bijker MS, Melief CJ, Offringa R & van der Burg SH (2007), Design and development of synthetic peptide vaccines: past, present and future, Expert Review of Vaccines 6(4).
- Weterings JJ, Khan S, Kriek NMA, van der Marel GA, Overkleeft HS, Ossendorp F, van der Burg SH, Drijfhout JW & Filippov DV (2007), Synthesis of modified and hybrid protein derived biopolymers, Biopolymers 88(4).
- Bijker, M.S.; Eeden, S.J.F. van den; Franken, K.L.; Melief, C.J.M.; Offringa, R. & Burg, S.H. van der (2007), CD8(+) CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity, Journal of Immunology 179(8).
- Bos R, Van Duikeren S, Van Hall T, Lauwen MM, Parrington M, Berinstein NL, McNeil B, Melief CJM, Verbeek JS, Van der Burg SH & Offringa R (2007), Characterization of antigen-specific immune responses induced by Canarypox virus Vaccines, Journal of Immunology 179(9).
- Khan S, Bijker MS, Weterings JJ, Tanke HJ, Adema GJ, van Hall T, Drijfhout JW, Melief CJM, Overkleeft HS, van der Marel GA, Filippov DV, van der Burg SH & Ossendorp F (2007), Distinct uptake mechanisms but similar intracellular processing of two different Toll-like receptor ligand-peptide conjugates in dendritic cells, Journal of Biological Chemistry 282(29).
- Mehta AM, Jordanova ES, van Wezel T, Uh HW, Corver WE, Kwappenberg KMC, Verduijn W, Kenter GG, van der Burg SH & Fleuren GJ (2007), Genetic variation of antigen processing machinery components and association with cervical carcinoma, Genes, Chromosomes and Cancer 46(6).
- Welters, M.J.P.; Bijker, M.S.; Eeden, S.J.F. van den; Franken, K.L.M.C.; Melief, C.J.M.; Offringa, R. & Burg, S.H. van der (2007), Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists (vol 25, pg 1379, 2007), Vaccine 25(41).
- Piersma SJ, Jordanova ES, van Poelgeest MIE, Kwappenberg KMC, van der Hulst JM, Drijfhout JW, Melief CJM, Kenter GG, Fleuren GJ, Offringa R & van der Burg SH (2007), High number of intraepithelial CD8(+) tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer, Cancer Research 67(1).
- Advies mbt investeringen in immunologische therapien ter bestrijding kanker
- Strategie advisory board