Sasha Chikunova
Guest researcher
- Name
- Dr. A. Chikunova
- Telephone
- +31 71 527 2727
- a.chikunova@lic.leidenuniv.nl
Guest researcher
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Macromolecular Biochemistry
- Chikunova A., Manley M.P., Heijjer C.N., Drenth C.S., Cramer‐Blok A.J., Ahmad M. Ud Din, Perrakis A. & Ubbink M. (2024), Conserved proline residues prevent dimerization and aggregation in the β‐lactamase BlaC, Protein Science 33(4): e4972.
- Sun J., Chikunova A., Boyle A.L., Voskamp P., Timmer M. & Ubbink M. (2023), Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase, International Journal of Biological Macromolecules 250: 126160.
- Alen I. van, Chikunova A., Zanten D.B. van, Block A.A. de, Timmer M., Brünle S. & Ubbink M. (2023), Asp179 in the class A β‐lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis, FEBS Journal 290: 4933-4949.
- Chikunova A. (31 May 2022), Essentiality of conserved amino acid residues in β-lactamase (PhD thesis. Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University). Supervisor(s): Ubbink M. & Perrakis A.
- Chikunova A. & Ubbink M. (2022), The roles of highly conserved, non‐catalytic residues in class A β‐lactamases, Protein Science 31(6): e4328.
- Elings W., Chikunova A., Zanten D.B. van, Drenth R., Ahmad M.U.D., Blok A.J., Timmer M., Perrakis A. & Ubbink M. (2021), Two β-lactamase variants with reduced clavulanic acid inhibition display different millisecond dynamics, Antimicrobial Agents and Chemotherapy 65(8): e02628-20.
- Alen I. van, Chikunova A., Safeer A.A., Ahmad M.U.D., Perrakis A. & Ubbink M. (2021), The G132S mutation enhances the resistance of mycobacterium tuberculosis β-lactamase against sulbactam, Biochemistry 60(28): 2236-2245.
- Chikunova A., Manley M.P., Ahmad M.U.D., Bilman T., Perrakis A. & Ubbink M. (2021), Conserved residues Glu37 and Trp229 play an essential role in protein folding of β‐lactamase, FEBS Journal 288(19): 5708-5722.