Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.
The research is aimed at understanding peptide, protein & nucleic acid structure, function and interactions. Particular interests comprise protein-protein interactions & enzyme function (Prof. Ubbink), biophysical aspects of protein - DNA interactions (Prof. Dame), peptide/protein-metal interactions, application of designed metallo-peptides and proteins (Dr. Boyle), protein - nanoparticle interactions for applicationd in light-driven redox catalysis (Prof. Jeuken) and protein aggregation in neurodegenerative diseases (Dr. Wentink).
The section houses equipment for recombinant protein production and a variety biophysical characterisation methods.
News
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Grants for fundamental research in Leiden -
Leiden chemists discover new ways in which single-celled organisms organise their DNA -
Not wrapping but folding: Bacteria also organise their DNA (but they do it a bit differently) -
How cells determine the fate of proteins (and can we do it too?) -
Caught in living cells: how bacteria regulate their genes to defend themselves
