Macromolecular Biochemistry

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.

The research is aimed at understanding peptide, protein & nucleic acid structure, function and interactions. Particular interests comprise protein-protein interactions & enzyme function (Prof. Ubbink), biophysical aspects of protein - DNA interactions (Prof. Dame), peptide/protein-metal interactions, application of designed metallo-peptides and proteins (Dr. Boyle), protein - nanoparticle interactions for applicationd in light-driven redox catalysis (Prof. Jeuken) and protein aggregation in neurodegenerative diseases (Dr. Wentink).

The section houses equipment for recombinant protein production and a variety biophysical characterisation methods.