Sander van Kasteren works on the interface between chemistry and immunology. He uses his background in organic synthesis and dendritic cell biology to study and manipulate the uptake and routing of antigen in dendritic cells.

More information about Sander van Kasteren

Curriculum Vitae

Personal information

Nationality:   Dutch
Date of birth:   18 June 1978

Education

2007   PhD, Faculty of Chemistry, University of Oxford, United Kingdom
Thesis title: ‘Probes for the in Vivo visualisation of cerebral inflammation’
Advisor: Prof. B.G. Davis
2001   MSc Chemistry & Medicinal Chemistry, Faculty of Chemistry, University of Edinburgh, Scotland

Current and previous research positions

2022 - now     Full Professor in Molecular Immunology, Leiden Institute of Chemistry, Leiden University, The Netherlands
2018 - 2022    Associate Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2012 – 2018   Tenure Track Assistant Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2010 – 2012   Post-doctoral researcher (Veni), Netherlands Cancer Institute, The Netherlands
2007 – 2010   Sir Henry Wellcome Postdoctoral Fellow, University of Dundee, Scotland

Grants, awards, recognitions since 2010

2021   Zon-MW Grant (with Jolanda de Vries and Geert van den Bogaart)
2020   ERC Consolidator Grant
2019   MS Motion Grant (with Wia Baron)
2017   NWO-BBoL Grant (with Ariane Briegel and Annemarie Meijer)
2017   NWO-CW ECHO Grant
2016   NWO-CW ECHO Grant (k€ 260)
2015   Reumafonds Fundamental Research Grant (k€ 157)
2014   EU ERC Starting Grant (k€ 1,500)
2014   Gravitation ICI (k€ 153)
2010   NWO-CW Veni (k€ 250)

Contribution to teaching and supervision

• One undergraduate course for BSc Life Science and Technology (Leiden/Delft): Immunology
• One course for MSc Chemistry and MSc Life Science and Technology at Leiden University: Chemical Immunology
• University College Leiden - Chemistry

Other responsibilities

2020 - 2021     NWO-Rubicon Panel Member
2020 - now     Associate Editor BSI – Immunotherapy Advances
2019 - 2023     Faculty Council FWN Leiden University
2019 - now     Board Member of the Institute of Chemical Immunology
2017 - now     Organiser of the Annual Institute of Chemical Immunology Conference Series
2017 - now     Scientific advisor and columnist of the ICI-magazine
2017                  Member of ERC Advisory Panel ‘The future of the ERC’
2016 - 2019     NWO Veni-Fellowship Scientific Panel Member
2015                  Organising panel of the 1st international chemical immunology conference in Oxford
2014 - 2020     Secretary of the Society of ‘Vernieuwingsimpuls’-researchers
2011 - 2016     Member of Backer prize committee (for selection of best organic chemistry thesis in Netherlands)
2013 - 2023     Organiser of the Leiden/LED3 Chemical Biology Lecture Series
2007 - now     Reviewer for, amongst others, Nature Communications, Nature Catalysis, Scientific Reports, ACS Central Science, Chemical Science, Journal of Medicinal Chemistry, ACS Chemical Biology, Journal of the American Chemical Society, Bioconjugate Chemistry, Frontiers in Chemical Biology, Frontiers in Immunology, and others.

Publication record including five recent representative publications

Full publication record: Google Scholar

• Pelgrom L.R., Davis G.M., O’Shaughnessy S., Wezenberg E.J., van Kasteren S.I., Finlay D.K., Sinclair L.V., ‘QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations’, Cell Reports 2023, 42 (8). DOI: 10.1016/j.celrep.2023.112828
• Bertheussen K., van de Plassche M.A.T., Bakkum T., Gagestein B., Ttofi I., Sarris A., Overkleeft H.S., Van Der Stelt M., van Kasteren S.I., ‘Employing Sterculic Acid–a naturally occurring 1, 2-cyclopropene fatty acid–for live-cell imaging of lipids by inverse electron-demand Diels-Alder reaction’. Angewandte Chemie International Edition 2022, 134 (38), e202207640. DOI: 10.1002/anie.202207640
• van der Leun A.M., Hoekstra M., Reinalda L., Scheele C.L., Toebes M., Van De Graaff M.J., Chen L.Y., Li H., Bercovich A., Lubling Y.A.M., Daivd E, Thommen D.S., Tanay A., Van Rheenen J., Amit I., van Kasteren S.I., Schumacher T.N., ‘Single-cell analysis of regions of interest (SCARI) using a photosensitive tag’, Nature Chemical Biology 2021, 17 (11), 1139-1147. DOI: 10.1038/s41589-021-00839-x
• Riera R., Hogervorst T.P., Doelman W., Ni Y., Pujals S., Bolli E., Codée J.D.C., van Kasteren S.I., Albertazzi L., ‘Single-molecule imaging of glycan–lectin interactions on cells with Glyco-PAINT. Nature Chemical Biology 2021, 17 (12), 1281-1288. DOI: 10.1038/s41589-021-00896-2
• Bakkum T., Heemskerk M.T., Bos E., Groenewold G.J.M., Oikonomeas-Koppasis N., Walburg K.V., V, van Veen S., van der Lienden M.J., van Leeuwen T., Haks M.C., Ottenhoff T.H.M., Koster A.J., van Kasteren S.I., ‘Bioorthogonal correlative light-electron microscopy of Mycobacterium tuberculosis in macrophages reveals the effect of antituberculosis drugs on subcellular bacterial distribution’ ACS Central Science 2020, 6 (11), 1997-2007. DOI: 10.1021/acscentsci.0c00539

Publications

Activities