Sander van Kasteren
Professor Molecular Immunology
- Name
- Prof.dr. S.I. van Kasteren
- Telephone
- +31 71 527 2727
- s.i.van.kasteren@chem.leidenuniv.nl
- ORCID iD
- 0000-0003-3733-818X
Sander van Kasteren works on the interface between chemistry and immunology. He uses his background in organic synthesis and dendritic cell biology to study and manipulate the uptake and routing of antigen in dendritic cells.
More information about Sander van Kasteren
PhD candidates
News
-
Four NWO Open Competition grants for Leiden researchers -
Proof of Concept grants for four Leiden researchers -
Scouring the brain for causes of psychiatric illnesses -
Gravitation funding for five projects with Leiden researchers -
Making the invisible visible with ‘click chemistry’ -
Sander van Kasteren: from molecule builder to Professor of Chemical Immunology -
Leiden researchers join forces against tuberculosis -
Improving therapeutic vaccines -
ERC Consolidator Grants for four Leiden researchers -
Unraveling the mysteries of Multiple Sclerosis -
Scientists have morals too -
NWO grants two IBL-proposals by interdisciplinary research consortia -
Two NWO ECHO grants for Leiden Chemistry -
A chemical connection that affects your immune system
Teaching
Former PhD candidates
Curriculum Vitae
Personal information
Nationality: Dutch
Date of birth: 18 June 1978
Education
2007 PhD, Faculty of Chemistry, University of Oxford, United Kingdom
Thesis title: ‘Probes for the in Vivo visualisation of cerebral inflammation’
Advisor: Prof. B.G. Davis
2001 MSc Chemistry & Medicinal Chemistry, Faculty of Chemistry, University of Edinburgh, Scotland
Current and previous research positions
2022 - now Full Professor in Molecular Immunology, Leiden Institute of Chemistry, Leiden University, The Netherlands
2018 - 2022 Associate Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2012 – 2018 Tenure Track Assistant Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2010 – 2012 Post-doctoral researcher (Veni), Netherlands Cancer Institute, The Netherlands
2007 – 2010 Sir Henry Wellcome Postdoctoral Fellow, University of Dundee, Scotland
Grants, awards, recognitions since 2010
2021 Zon-MW Grant (with Jolanda de Vries and Geert van den Bogaart)
2020 ERC Consolidator Grant
2019 MS Motion Grant (with Wia Baron)
2017 NWO-BBoL Grant (with Ariane Briegel and Annemarie Meijer)
2017 NWO-CW ECHO Grant
2016 NWO-CW ECHO Grant (k€ 260)
2015 Reumafonds Fundamental Research Grant (k€ 157)
2014 EU ERC Starting Grant (k€ 1,500)
2014 Gravitation ICI (k€ 153)
2010 NWO-CW Veni (k€ 250)
Contribution to teaching and supervision
- One undergraduate course for BSc Life Science and Technology (Leiden/Delft): Immunology
- One course for MSc Chemistry and MSc Life Science and Technology at Leiden University: Chemical Immunology
- University College Leiden - Chemistry
Other responsibilities
2020 - 2021 NWO-Rubicon Panel Member
2020 - now Associate Editor BSI – Immunotherapy Advances
2019 - 2023 Faculty Council FWN Leiden University
2019 - now Board Member of the Institute of Chemical Immunology
2017 - now Organiser of the Annual Institute of Chemical Immunology Conference Series
2017 - now Scientific advisor and columnist of the ICI-magazine
2017 Member of ERC Advisory Panel ‘The future of the ERC’
2016 - 2019 NWO Veni-Fellowship Scientific Panel Member
2015 Organising panel of the 1st international chemical immunology conference in Oxford
2014 - 2020 Secretary of the Society of ‘Vernieuwingsimpuls’-researchers
2011 - 2016 Member of Backer prize committee (for selection of best organic chemistry thesis in Netherlands)
2013 - 2023 Organiser of the Leiden/LED3 Chemical Biology Lecture Series
2007 - now Reviewer for, amongst others, Nature Communications, Nature Catalysis, Scientific Reports, ACS Central Science, Chemical Science, Journal of Medicinal Chemistry, ACS Chemical Biology, Journal of the American Chemical Society, Bioconjugate Chemistry, Frontiers in Chemical Biology, Frontiers in Immunology, and others.
Publication record including five recent representative publications
Full publication record: Google Scholar
- Pelgrom L.R., Davis G.M., O’Shaughnessy S., Wezenberg E.J., van Kasteren S.I., Finlay D.K., Sinclair L.V., ‘QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations’, Cell Reports 2023, 42 (8). DOI: 10.1016/j.celrep.2023.112828
- Bertheussen K., van de Plassche M.A.T., Bakkum T., Gagestein B., Ttofi I., Sarris A., Overkleeft H.S., Van Der Stelt M., van Kasteren S.I., ‘Employing Sterculic Acid–a naturally occurring 1, 2-cyclopropene fatty acid–for live-cell imaging of lipids by inverse electron-demand Diels-Alder reaction’. Angewandte Chemie International Edition 2022, 134 (38), e202207640. DOI: 10.1002/anie.202207640
- van der Leun A.M., Hoekstra M., Reinalda L., Scheele C.L., Toebes M., Van De Graaff M.J., Chen L.Y., Li H., Bercovich A., Lubling Y.A.M., Daivd E, Thommen D.S., Tanay A., Van Rheenen J., Amit I., van Kasteren S.I., Schumacher T.N., ‘Single-cell analysis of regions of interest (SCARI) using a photosensitive tag’, Nature Chemical Biology 2021, 17 (11), 1139-1147. DOI: 10.1038/s41589-021-00839-x
- Riera R., Hogervorst T.P., Doelman W., Ni Y., Pujals S., Bolli E., Codée J.D.C., van Kasteren S.I., Albertazzi L., ‘Single-molecule imaging of glycan–lectin interactions on cells with Glyco-PAINT. Nature Chemical Biology 2021, 17 (12), 1281-1288. DOI: 10.1038/s41589-021-00896-2
- Bakkum T., Heemskerk M.T., Bos E., Groenewold G.J.M., Oikonomeas-Koppasis N., Walburg K.V., V, van Veen S., van der Lienden M.J., van Leeuwen T., Haks M.C., Ottenhoff T.H.M., Koster A.J., van Kasteren S.I., ‘Bioorthogonal correlative light-electron microscopy of Mycobacterium tuberculosis in macrophages reveals the effect of antituberculosis drugs on subcellular bacterial distribution’ ACS Central Science 2020, 6 (11), 1997-2007. DOI: 10.1021/acscentsci.0c00539
Professor Molecular Immunology
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Chemische Biologie & Immunologie
- Wulp W. van der, Remst D.F.G., Kester M.G.D., Hagedoorn R.S., Parren P.W.H.I., Kasteren S.I. van, Schuurman J., Hoeben R.C., Ressing M.E., Bleijlevens B. & Heemskerk M.H.M. (2024), Antibody-mediated delivery of viral epitopes to redirect EBV-specific CD8+ T-cell immunity towards cancer cells, Cancer Gene Therapy 31: 58-68.
- Doelman W., Ligthart N.A.M., Plassche M.A.T. van de, Geus M.A.R. de, Reinalda L., Isendoorn M.M.E., Filippov D.V. & Kasteren S.I. van (2024), Synthesis of peptides containing a combination of free and 2-trans-cyclooctene carbamate protected lysine residues, ChemBioChem 25(4): e202300786.
- Doelman W., Reijnen R.C., Dijksman N., Janssen A.P.A., Driel N. van, Hart B.A., Philippens I., Araman C., Baron W. & Kasteren S.I. van (2023), Citrullinated human and murine MOG35-55 display distinct biophysical and biochemical behavior, The Journal of Biological Chemistry 299(4): 103065.
- Leeuwen T. van, Doelman W., Kieboom R.W.R. van den, Florea B.I. & Kasteren S.I. van (2023), Bioorthogonal peptide enrichment from complex samples using a rink-amide-based catch-and-release strategy, ChemBioChem 24(8): e202300082.
- Ligthart N.A.M., Geus M.A.R. de, Plassche M.A.T. van de, Torres Garcia D., Isendoorn M.M.E., Reinalda L., Ofman D.E., Leeuwen T. van & Kasteren S.I. van (2023), A lysosome-targeted tetrazine for organelle-specific click-to-release chemistry in antigen presenting cells, Journal of the American Chemical Society 145(23): 12630-12640.
- Wulp W. van der, Gram A.M., Bleijlevens B., Hagedoorn R.S., Araman M.C., Kim R.Q., Drijfhout J.W., Parren P.W.H.I., Hibbert R.G., Hoeben R.C., Kasteren S.I. van, Schuurman J., Ressing M.E. & Heemskerk M.H.M. (2023), Comparison of methods generating antibody-epitope conjugates for targeting cancer with virus-specific T cells, Frontiers in Immunology 14: 1183914.
- Fan B.W., Torres Garcia D., Salehi M., Webber M.J., Kasteren S.I. van & Eelkema R. (2023), Dynamic covalent dextran hydrogels as injectable, self-adjuvating peptide vaccine depots, ACS Chemical Biology 18(3): 652-659.
- Pelgrom L.R., Davis G.M., O'Shaughnessy S., Wezenberg E.J.M., Kasteren S.I. van, Finlay D.K. & Sinclair L.V. (2023), QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations, Cell Reports 42(8): 112828.
- Kasteren S.I. van & Rozen D.E. (2023), Using click chemistry to study microbial ecology and evolution, ISME Communications 3: 9.
- Bertheussen K., Plassche M.A.T. van de, Bakkum T., Gagestein B., Ttofi I., Sarris A.J.C., Overkleeft H.S., Stelt M. van der & Kasteren S.I. van (2022), Live-cell imaging of sterculic acid - a naturally occurring 1,2-cyclopropene fatty acid - by bioorthogonal reaction with turn-on tetrazine-fluorophore conjugates, Angewandte Chemie (International Edition) 61(38): e202207640.
- Doelman W. & Kasteren S.I. van (2022), Synthesis of glycopeptides and glycopeptide conjugates, Organic and Biomolecular Chemistry 20(33): 6487-6507.
- Torres-Garcia D., Plassche M.A.T. van de, Boven E. van, Leeuwen T. van, Groenewold M.G.J., Sarris A.J.C., Klein L., Overkleeft H.S. & Kasteren S.I. van (2022), Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activities in situ, RSC Chemical Biology 3(11): 1325-1330.
- Doelman W., Marqvorsen M.H.S., Chiodo F., Bruijns S.C.M., Marel G.A. van der, Kooyk Y. van, Kasteren S.I. van & Araman C. (2021), Synthesis of asparagine derivatives harboring a Lewis X type DC-SIGN ligand and evaluation of their impact on immunomodulation in multiple sclerosis, Chemistry: a European Journal 27(8): 2742-2752.
- Dalen F.J. van, Bakkum T., Leeuwen T. van, Groenewold G.J.M., Deu E., Koster A.J., Kasteren S.I. van & Verdoes M. (2021), Application of a highly selective cathepsin S two-step activity-based probe in multicolor bio-orthogonal correlative light-electron microscopy, Frontiers in Chemistry 8: 628433.
- Ignacio B.J., Bakkum T., Bonger K.M., Martin N.I. & Kasteren S.I. van (2021), Metabolic labeling probes for interrogation of the host-pathogen interaction, Organic and Biomolecular Chemistry 19(13): 2856-2870.
- Andrian T., Bakkum T., Elsland D.M. van, Bos E., Koster A.J., Albertazzi L., Kasteren S.I. van & Pujals S. (2021), Super-resolution correlative light-electron microscopy using a click-chemistry approach for studying intracellular trafficking. In: Müller-Reichert T. & Verkade P. (Eds.), Correlative Light and Electron Microscopy IV. Methods in Cell Biology no. 162: Elsevier. 303-331.
- Leeuwen T. van, Araman C., Pournara L.P., Kampstra A.S.B., Bakkum T., Marqvorsen M.H.S., Nascimento C.R., Groenewold G.J.M., Wulp W. van der, Camps M.G.M., Janssen G.M.C., Veelen P.A. van, Westen G.J.P. van Janssen A.P.A., Florea B.I., Overkleeft H.S., Ossendorp F.A., Toes R.E.M. & Kasteren S.I. van (2021), Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens, RSC Chemical Biology 2(3): 855-862.
- Leun A.M. van der, Hoekstra M.E., Reinalda L., Scheele C.L.G.J., Toebes M., Graaff M.J. van de, Chen L.Y.Y., Li H., Bercovich A., Lubling Y., David E., Thommen D.S., Tanay A., Rheenen J. van, Amit I., Kasteren S.I. van & Schumacher T.N. (2021), Single-cell analysis of regions of interest (SCARI) using a photosensitive tag, Nature Chemical Biology 17: 1139-1147.
- Riera R., Hogervorst T.P., Doelman W., Ni Y., Pujals S., Bolli E., Codee J.D.C., Kasteren S.I. van & Albertazzi L. (2021), Single-molecule imaging of glycan-lectin interactions on cells with Glyco-PAINT, Nature Chemical Biology 17: 1281-1288.
- Dou Y., Jansen D.T.S.L., Bosch A. van den, Man R.A. de, Montfoort N. van, Araman C., Kasteren S.I. van, Zom G.G., Krebber W.J., Melief C.J.M., Woltman A.M. & Buschow S.I. (2020), Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients, Antiviral Research 178: 104746.
- Geus M.A.R. de, Maurits E., Sarris A.J.C., Hansen T., Kloet M.S., Kamphorst K., Hoeve W. ten, Robillard M.S., Pannwitz A., Bonnet S.A., Codée J.D.C., Filippov D.V., Overkleeft H.S. & Kasteren S.I. van (2020), Fluorogenic Bifunctional Trans-cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics, Chemistry: a European Journal 26(44): 9900-9904.
- Maurits E., Graaff M.J. van de, Maiorana S., Wander D.P.A., Dekker P.M., Zanden S.Y. van der, Florea B.I., Neefjes J.J.C., Overkleeft H.S. & Kasteren S.I. van (2020), Immunoproteasome inhibitor-doxorubicin conjugates target multiple myeloma cells and release doxorubicin upon low-dose photon irradiation, Journal of the American Chemical Society 142(16): 7250-7253.
- Brevé T.G., Filius M., Araman C., Helm M.P. van der, Hagedoorn P.L., Joo C., Kasteren S.I. van & Eelkema R. (2020), Conditional Copper-Catalyzed Azide-Alkyne Cycloaddition by Catalyst Encapsulation, Angewandte Chemie (International Edition) 59(24): 9340-9344.
- Busemann A. Araman M.C. Flaspohler I. Pratesi A. Zhou X.Q. Rixel V.H.S. van Siegler M.A. Messori L. Kasteren S.I. van Bonnet S.A. (2020), Alkyne Functionalization of a Photoactivated Ruthenium Polypyridyl Complex for Click-Enabled Serum Albumin Interaction Studies, Journal of Inorganic Chemistry 59(11): 7710-7720.
- Graaff M.J. van de Oosenbrug T. Marqvorsen M.H.S. Nascimento C.R. Geus M.A.R. de Manoury B. Ressing M.E. Kasteren S.I. van (2020), Conditionally controlling human TLR2 activity via Trans-Cyclooctene Caged Ligands, Bioconjugate Chemistry 31(6): 1685-1692.
- Voorneveld J., Florea B.I., Bakkum T., Mendowicz R.J., Veer M.S. van der, Gagestein B., Kasteren S.I. van, Stelt M. van der, Overkleeft H.S. & Filippov D.V. (2020), Olaparib-Based Photoaffinity Probes for PARP-1 Detection in Living Cells, ChemBioChem 21: 1-5.
- Oosenbrug T., Graaff M.J. van de, Haks M.C., Kasteren S.I. van & Ressing M.E. (2020), An alternative model for type I interferon induction downstream of human TLR2, Journal of Biological Chemistry 295: 14325-14342.
- Bakkum T., Heemskerk M.T., Bos E., Groenewold G.J.M., Oikonomeas-Koppasis N., Walburg K.V., Veen S. van, Lienden M.J.C. van der, Leeuwen T. van, Haks M.C., Ottenhoff T.H.M., Koster A.J. & Kasteren S.I. van (2020), Bioorthogonal correlative light-electron microscopy of mycobacterium tuberculosis in macrophages reveals the effect of antituberculosis drugs on subcellular bacterial distribution, ACS Central Science 6(11): 1997-2007.
- Geus M.A.R. de, Groenewold G.J.M., Maurits E., Araman C. & Kasteren S.I. van (2020), Synthetic methodology towards allylic trans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of the lac repressor, Chemical Science 11(37): 10175-10179.
- Meel E. van, Bos E., Lienden M.J.C. van der, Overkleeft H.S., Kasteren S.I. van, Koster A.J. & Aerts J.M.F.G. (2019), Localization of Active Endogenous and Exogenous GBA by Correlative Light-Electron Microscopy in Human Fibroblasts, Traffic 20(5): 346-356.
- Marqvorsen M.H.S., Paramasivam S., Doelman W., Fairbanks A.J. & Kasteren S.I. van (2019), Efficient synthesis and enzymatic extension of an N-GlcNAz asparagine building block, Chemical Communications 55(36): 5287-5290.
- Marqvorsen M.H.S., Araman C. & Kasteren S.I. van (2019), Going Native: Synthesis of Glycoproteins and Glycopeptides via Native Linkages To Study Glycan-Specific Roles in the Immune System, Bioconjugate Chemistry 30(11): 2715-2726.
- Araman C., Gent M. van, Meeuwenoord N.J., Heijmans N., Marqvorsen M.H.S., Faber B.W., Hart B.A. 't & Kasteren S.I. van (2019), Amyloid-like behavior of site-specifically citrullinated myelin oligodendrocyte protein (MOG) peptide fragments inside EBV infected B-cells influences their cytotoxicity and autoimmunogenicity, Biochemistry 58(6): 763-775.
- Gracht A.M.F. van der, Geus M.A.R. de, Camps M.G.M., Ruckwardt T.J., Sarris A.J.C., Bremmers J., Maurits E., Pawlak J.B., Posthoorn M.M., Bonger K.M., Filippov D.V., Overkleeft H.S., Robillard M.S., Ossendorp F. & Kasteren S.I. van (2018), Chemical control over T-cell activation in vivo using deprotection of trans-cyclooctene-modified epitopes, ACS Chemical Biology 13(6): 1569-1576.
- Soethoudt M., Stolze S.C., Westphal M.V., Stralen L. van, Martella A., Rooden E.J. van, Guba W., Varga Z.V., Deng H., Kasteren S.I. van, Grether U., IJzerman A.P., Pacher P., Carreira E.M., Overkleeft H.S., Heitman L.H., Ioan-Facsinay A. & Stelt M. van der (2018), A selective photoaffinity probe that enables assessment of cannabinoid CB2 receptor expression and ligand engagement in human cells, Journal of the American Chemical Society 140(19): 6067-6075.
- Elsland D.M. van, Pujals S., Bakkum T., Bos E., Oikonomeas-Koppasis N., Berlin I., Neefjes J., Meijer A.H., Koster A.J., Albertazzi L. & Kasteren S.I. van (2018), Ultrastructural Imaging of Salmonella-Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens, ChemBioChem 19(16): 1766-1770.
- Bakkum T., Leeuwen T. van, Sarris A.J.C., Elsland D.M. van, Poulcharidis D., Overkleeft H.S. & Kasteren S.I. van (2018), Quantification of Bioorthogonal Stability in Immune Phagocytes Using Flow Cytometry Reveals Rapid Degradation of Strained Alkynes, ACS Chemical Biology 13(5): 1173-1179.
- Sarris A.J.C., Hansen T., Geus M.A.R. de, Maurits E., Doelman W., Overkleeft H.S., Codée J.D.C., Filippov D.V. & Kasteren S.I. van (2018), Fast and pH-Independent Elimination of trans-Cyclooctene by Using Aminoethyl-Functionalized Tetrazines, Chemistry: a European Journal 24(68): 18075-18081.
- Hos B.J., Tondini E., Kasteren S.I. van & Ossendorp F.A. (2018), Approaches to Improve Chemically Defined Synthetic Peptide Vaccines, Frontiers in Immunology 9: 884.
- Martínez-Fábregas J., Prescott A., Kasteren S.I. van, Pedrioli D.L., McLean I., Moles A., Reinheckel T., Poli V. & Watts C. (2018), Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis, Nature Communications 9(1): 5343.
- Stathopoulou C., Gangaplara A., Mallett G., Flomerfelt F.A., Liniany L.P., Knight D., Samsel L.A., Berlinguer-Palmini R., Yim J.J., Felizardo T.C., Eckhaus M.A., Edgington-Mitchell L., Martinez-Fabregas J., Zhu J., Fowler D.H., Laurence A., Kasteren S.I. van, Watts C., Bogyo M., Amarnath S. & Shevach E.M. (2018), PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells, Immunity 49(2): 247-263.e7.
- Kasteren S.I. van, Neefjes J.J.C. & Ovaa H. (2018), Creating molecules that modulate immune responses, Nature Reviews Chemistry 2: 184-193.
- Pawlak J.B. & Kasteren S.I. van (2017), Antigen Processing and Cross-Presentation, eLS : 1-11.
- Poulcharidis D., Belfor K., Kros A. & Kasteren S.I. van (2017), A flow cytometry assay to quantify intercellular exchange of membrane components, Chemical Science - hard copy 8(8): 5585-5590.
- Kasteren S.I. van, Florea B.I. & Overkleeft H.S. (2017), Activity-Based Protein Profiling: From Chemical Novelty to Biomedical Stalwart. In: Florea B.I. & Overkleeft H.S. (Eds.), Activity-based Proteomics: Methods and Protocols. Methods in Molecular Biology. New York: Humana Press. 1-8.
- Oosenbrug T., Graaff M.J. van de, Ressing M.E. & Kasteren S.I. van (2017), Chemical Tools for Studying TLR Signaling Dynamics, Cell chemical biology 24(7): 801-812.
- Perez-Balderas F., Kasteren S.I. van, Aljabali A.A., Wals K., Serres S., Jefferson A., Sarmiento Soto M., Khrapitchev A.A., Larkin J.R., Bristow C., Lee S.S., Bort G., De Simone F., Campbell S.J., Choudhury R.P., Sibson N.R., Anthony D.C. & Davis B.G. (2017), Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI, Nature Communications 8: 1-10.
- Elsland D.M. van, Bos E., Pawlak J.B., Overkleeft H.S., Koster A.J. & Kasteren S.I. van (2017), Correlative light and electron microscopy reveals discrepancy between gold and fluorescence labelling, Journal of Microscopy 267(3): 309-317.
- Elsland D.M. van & Kasteren S.I. van (2016), Imaging Bioorthogonal Groups in Their Ultrastructural Context with Electron Microscopy, Angewandte Chemie (International Edition) 55(33): 9472-9473.
- Versluis F., Elsland D.M. van, Mytnyk S., Perrier D.L., Trausel F., Poolman J.M., Maity C., Sage V.A. le, Kasteren S.I. van, Esch J.H. & Eelkema R. (2016), Negatively Charged Lipid Membranes Catalyze Supramolecular Hydrogel Formation, Journal of the American Chemical Society 138(28): 8670-8673.
- Poolman J.M., Maity C., Boekhoven J., Mee L. van der, Sage V.A.A. le, Groenewold G.J.M., Kasteren S.I. van, Versluis F., Esch J.H. van & Eelkema R. (2016), A toolbox for controlling the properties and functionalisation of hydrazone-based supramolecular hydrogels, Journal of Materials Chemistry B 4(5): 852-858.
- Pawlak J.B., Hos B.J., Graaff M.J. van de, Megantari O.A., Meeuwenoord N., Overkleeft H.S., Filippov D.V., Ossendorp F. & Kasteren S.I. van. (2016), The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes, ACS Chemical Biology : .
- Elsland D.M. van, Bos E., Boer W. de, Overkleeft H.S., Koster A.J. & Kasteren S.I. van (2016), Detection of bioorthogonal groups by correlative light and electron microscopy allows imaging of degraded bacteria in phagocytes, Chemical Science 7(1): 752-758.
- Jagessar S.A., Holtman I.R., Hofman S., Morandi E., Heijmans N., Laman J.D., Gran B., Faber B.W., Kasteren S.I. van, Eggen B.J. & t Hart B.A. (2016), Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein, Journal of Immunology 197(4): 1074-1088.
- Elsland D.M. van, Bos E., Overkleeft H.S., Koster A.J. & Kasteren S.I. van (2015), The potential of bioorthogonal chemistry for correlative light and electron microscopy: a call to arms, Journal of Chemical Biology 8(4): 1-5.
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- Pawlak J.B., Gential G.P.P., Ruckwardt T.J., Bremmers J.S., Meeuwenoord N.J., Ossendorp F.A., Overkleeft H.S., Filippov D.V. & Kasteren S.I. (2015), Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation, Angewandte Chemie (International Edition) 54(19): 5628-5631.
- Kasteren S.I. van, Overkleeft H.S., Ovaa H. & Neefjes J.J.C. (2014), Chemical biology of antigen presentation by MHC molecules, Current Opinion in Immunology 26: 21-31.
- Engelsma Sander B., Willems Lianne I., Van Paaschen Claudia E., Van Kasteren Sander I., Van der Marel Gijsbert A., Overkleeft Herman S. & Filippov Dmitri V. (2014), Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels-Alder Ligation, 16(10): 2744-2747.
- Willems Lianne I., Overkleeft Herman S. & Van Kasteren Sander I. (2014), Current Developments in Activity-Based Protein Profiling, Bioconjugate Chemistry 25(7): 1181-1191.
- Burkhard C., Verheije M.H., Wicht O., Kasteren S.I. van, Kuppeveld F.J. van, Haagmans B.L., Pelkmans L., Rottier P.J.M., Bosch B.J. & Haan C.A.M. de (2014), Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner, PLoS Pathogens 10(11): .
- Kasteren S.I. van & Overkleeft H.S. (2014), Endo-lysosomal proteases in antigen presentation , Current Opinion in Chemical Biology 23(0): 8 - 15.
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- Ekkebus R., Kasteren S.I. van, Kulathu Y., Scholten A., Berlin I., Geurink P.P., Jong A. de, Goerdayal S., Neefjes J.J.C., Heck A.J.R., Komander D. & Ovaa H. (2013), On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases, Journal of the American Chemical Society 135(8): 2867-2870.
- Kasteren S. van (2012), Synthesis of post-translationally modified proteins, Biochemical Society Transactions 40: 929-944.
- Kasteren S.I. van, Berlin I., Colbert J.D., Keane D., Ovaa H. & Watts C. (2011), A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function, ACS Chemical Biology 6(11): 1198-1204.
- Sibson N.R., Anthony D.C., Kasteren S. van, Dickens A., Perez-Balderas F., McAteer M.A., Choudhury R.P. & Davis B.G. (2011), Molecular MRI Approaches to the Detection of CNS Inflammation. In: , Magnetic Resonance Neuroimaging no. 711: Humana Press. 379-396.
- Kujala P., Raymond C.R., Romeijn M., Godsave S.F., Kasteren S.I. van, Wille H., Prusiner S.B., Mabbott N.A. & Peters P.J. (2011), Prion Uptake in the Gut: Identification of the First Uptake and Replication Sites, PLoS Pathogens 7(12): e1002449.
- Garnier P., Wang X.T., Robinson M.A., Kasteren S. van, Perkins A.C., Frier M., Fairbanks A.J. & Davis B.G. (2010), Lectin-directed enzyme activated prodrug therapy (LEAPT): Synthesis and evaluation of rhamnose-capped prodrugs, Journal of Drug Targeting 18(10): 794-802.
- Kasteren S.I. van, Garnier P. & Davis B.G. (2009), Chemical Methods for Mimicking Post-Translational Modifications. In: , Protein Engineering no. 22: Springer Berlin Heidelberg. 97-125.
- Kasteren S.I. van, Campbell S.J., Serres S., Anthony D.C., Sibson N.R. & Davis B.G. (2009), Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease, Proceedings of the National Academy of Sciences 106(1): 18-23.
- Serres S., Anthony D.C., Jiang Y., Broom K.A., Campbell S.J., Tyler D.J., Kasteren S.I. van, Davis B.G. & Sibson N.R. (2009), Systemic Inflammatory Response Reactivates Immune-Mediated Lesions in Rat Brain, Journal of Neuroscience 29(15): 4820-4828.
- Gamblin D.P., Kasteren S. van, Bernardes G.J.L., Chalker J.M., Oldham N.J., Fairbanks A.J. & Davis B.G. (2008), Chemical site-selective prenylation of proteins, Molecular Biosystems 4(6): 558-561.
- Gamblin D.P., Kasteren S.I. van, Chalker J.M. & Davis B.G. (2008), Chemical approaches to mapping the function of post-translational modifications, FEBS Journal 275(9): 1949-1959.
- Davis B., Kasteren S. van, Anthony D. & Sibson N. (2007), Imaging agent comprising iron containing colloidal particle conjugated to oligosaccharides (patent no. 2,007,020,450). WO. [patent].
- Kasteren S.I. van, Kramer H.B., Jensen H.H., Campbell S.J., Kirkpatrick J., Oldham N.J., Anthony D.C. & Davis B.G. (2007), Expanding the diversity of chemical protein modification allows post-translational mimicry, 446(7139): 1105-1109.
- Kasteren S.I. van, Kramer H.B., Gamblin D.P. & Davis B.G. (2007), Site-selective glycosylation of proteins: creating synthetic glycoproteins, Nature Protocols 2(12): 3185-3194.
- Gamblin D.P., Garnier P., Kasteren S. van, Oldham N.J., Fairbanks A.J. & Davis B.G. (2004), Glyco-SeS: Selenenylsulfide-mediated protein glycoconjugation - A new strategy in post-translational modification, Angewandte Chemie (International Edition) 43(7): 828-833.
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