Rolf Boot
Assistant professor
- Name
- Dr. R.G. Boot
- Telephone
- +31 71 527 4213
- r.g.boot@lic.leidenuniv.nl
- ORCID iD
- 0000-0002-7031-3390
Curriculum Vitae
Personal information
Nationality: Dutch
Date of birth: 4 April 1963
Education
1997 PhD, Medical Biochemistry AMC Amsterdam, University of Amsterdam, 16 October 1997. Thesis title: “Gaucher Disease and Chitotriosidase, Biochemical Investigations”
Advisors: Prof. H.F. Tabak and Dr. J.M.F.G. Aerts
1992 MSc in Biology, University of Amsterdam, The Netherlands
Current and previous research positions
2015 – now Assistant Professor, Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, The Netherlands
2003 – 2014 Assistant Professor, Medical Biochemistry, AMC Amsterdam, University of Amsterdam, The Netherlands
1997 – 2003 Postdoctoral researcher, AMC Amsterdam, University of Amsterdam, The Netherlands
Contribution to teaching and supervision
- Courses for MSc Chemistry and MSc Life Science and Technology
- Courses for BSc Chemistry and Life Science and Technology
- Courses for Pre-University College at Leiden University
Co-supervision of 7 PhD students and 2 postdoctoral fellows since 2010.
Other responsibilities
- Reviewer several journals
Publication record including five recent representative publications
H-index 46 (Web of Science)
Full publication record: Leiden University
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Lelieveld LT, Gerhardt S, Maas S, Zwiers KC, de Wit C, Beijk EH, Ferraz MJ, Artola M, Meijer AH, Tudorache C, Salvatori D, Boot RG, Aerts JMFG. Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish. J Lipid Res. 2022, 63(5). DOI: 10.1016/j.jlr.2022.100199
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Aerts JMFG, Artola M, van Eijk M, Ferraz MJ, Boot RG. Glycosphingolipids and Infection. Potential New Therapeutic Avenues. Front Cell Dev Biol. 2019;7:324. DOI: 10.3389/fcell.2019.00324
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Lelieveld LT, Mirzaian M, Kuo CL, Artola M, Ferraz MJ, Peter REA, Akiyama H, Greimel P, van den Berg RJBHN, Overkleeft HS, Boot RG, Meijer AH, Aerts JMFG. Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish. J Lipid Res. 2019;60(11):1851-1867. DOI: 10.1194/jlr.ra119000154
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Boer DE, Mirzaian M, Ferraz MJ, Zwiers KC, Baks MV, Hazeu MD, Ottenhoff R, Marques ARA, Meijer R, Roos JCP, Cox TM, Boot RG, Pannu N, Overkleeft HS, Artola M, Aerts JM. Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions. J Lipid Res. 2021;62:100018. DOI: 10.1194/jlr.RA120001043
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Artola M, Kuo CL, Lelieveld LT, Rowland RJ, van der Marel GA, Codée JDC, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS. Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish. J Am Chem Soc. 2019 Mar 13;141(10):4214-4218. DOI: 10.1021/jacs.9b00056
Assistant professor
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- Kuo C.L., Su Q., Nieuwendijk A.M.C.H. van den, Beenakker T.J.M., Offen W.A., Willems L.I., Boot R.G., Sarris A.J.C., Rosa Alcalde Marques A.R.A., Codée J.D.C., Marel G.A. van der, Florea B.I., Davies G.J., Overkleeft H.S. & Aerts J.M.F.G. (2023), The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe, Organic and Biomolecular Chemistry 21(38): 7813-7820.
- Cabasso O., Kuppuramalingam A., Lelieveld L.T., Lienden M.J.C. van der, Boot R.G., Aerts J.M.F.G. & Horowitz M. (2023), Animal models for the study of Gaucher disease, International Journal of Molecular Sciences 24(22): 16035.
- Su Q., Schroder S.P., Lelieveld L.T., Guimaraes Da Lomba Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola Perez de Azanza M.E. & Kuo C.L. (2023), Corrigendum: Xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase, ChemBioChem 24(3): e202300728.
- Lelieveld L.T., Gerhardt S., Maas S., Zwiers K.C., Wit C. de, Beijk E.H., Guimaraes Da Lomba Ferraz M.J., Artola Perez de Azanza M.E., Meijer A.H., Tudorache C., Salvatori D., Boot R.G. & Aerts J.M.F.G. (2022), Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish, Journal of Lipid Research 63(5): 100199.
- Lienden M.J.C. van der, Aten J., Boot R.G., Eijk M.C. van, Aarts J.M.F.G. & Kuo C.L. (2022), HEPES‐buffering of bicarbonate‐containing culture medium perturbs lysosomal glucocerebrosidase activity, Journal of Cellular Biochemistry 123(5): 893-905.
- Kok K., Zwiers K.C., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Artola M. (2021), Fabry disease: molecular basis, pathophysiology, diagnostics and potential therapeutic directions, Biomolecules 11(2): 271.
- Boer D.E., Mirzaian M., Ferraz M.J., Zwiers K.C., Baks M.V., Hazeu M.D., Ottenhoff R., Marques A.R.A., Meijer R., Roos J.C.P., Cox T.M., Boot R.G., Pannu N., Overkleeft H.S., Artola M. & Aerts J.M.F.G. (2021), Human glucocerebrosidase mediates formation of xylosyl-cholesterol by beta-xylosidase and transxylosidase reactions, Journal of Lipid Research 62: 100018.
- Su Q., Schröder S.P., Lelieveld L.T., Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola M. & Kuo C.L. (2021), Xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase, ChemBioChem 22(21): 3090-3098.
- Armstrong Z., Kuo C.L., Lahav D., Liu B., Johnson R., Beenakker T.J.M., Boer C. de, Wong C.S., Rijssel E.R. van, Debets M.F., Florea B.I., Hissink C., Boot R.G., Geurink P.P., Ovaa H., Stelt M. van der, Marel G.A. van der, Codée J.D.C., Aerts J.M.F.G., Wu L., Overkleeft H.S. & Davies G.J. (2020), Manno-epi-cyclophellitols enable activity-based protein profiling of human α-mannosidases and discovery of new golgi mannosidase II inhibitors, Journal of the American Chemical Society 142(30): 13021-13029.
- Boer D.E.C., Mirzaian M., Ferraz M.J., Zwiers K.C., Baks M.V., Hazeu M.D., Ottenhoff R., Marques A.R.A., Meijer R., Roos J.P.C., Cox T.M., Boot R.G., Pannu N., Overkleeft H.S., Artola M. & Aerts J.M.F.G. (2020), Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions, Journal of Lipid Research 61(12): jlr.RA120001043.
- Eijk M. van, Ferraz M.J., Boot R.G. & Aerts J.M.F.G. (2020), Lyso-glycosphingolipids: presence and consequences, Essays in Biochemistry 64(3): 565-578.
- Artola M., Kuo C.L., Lelieveld L.T., Rowland R.J., Marel G.A. van der, Codée J.D.C., Boot R.G., Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2019), Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish, Journal of the American Chemical Society 141(10): 4214-4218.
- Lelieveld L.T., Mirzaian M., Kuo C.L., Artola Perez de Azanza M.E., Guimaraes da Lomba Ferraz M.J., Peter R.E.A., Akiyama H., Greimel P., Berg R.J.B.H.N. van den, Overkleeft H.S., Boot R.G., Meijer A. & Aerts J.M.F.G. (2019), Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish, Journal of Lipid Research 60(11): 1851-1867.
- Moro Chao D.H., Wang Y., Foppen E., Ottenhoff R., Roomen C. van, Parlevliet E.T., Eijk M.C. van, Verhoek M., Boot R.G., Marques A.R., Scheij S., Mirzaian M., Kooijman S., Jansen K., Wang D., Mergen C., Seeley R.J., Tschöp M.H., Overkleeft H.S., Rensen P.C.N., Kalsbeek A., Aerts J.M.F.G. & Yi C.X. (2019), The iminosugar AMP-DNM improves satiety and activates brown adipose tissue through GLP1, Diabetes 68(12): 2223-2234.
- Aerts J.M.F.G., Artola M.E., Eijk M.C. van, Ferraz M.J. & Boot R.G. (2019), Glycosphingolipids and infection. Potential new therapeutic avenues, Frontiers in Cell and Developmental Biology 7: 324.
- Rooden E.J. van, Esbroeck A.C.M. van, Baggelaar M.P., Deng H., Florea B.I., Rosa Alcalde Marques A., Ottenhoff R., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Stelt M. van der (2018), Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain, Frontiers in Neuroscience 12: 440.
- Lienden M.J.C. van der, Gaspar P., Boot R.G., Aerts J.M.F.G. & Eijk M.C. van (2018), Glycoprotein Non-Metastatic Protein B: An Emerging Biomarker for Lysosomal Dysfunction in Macrophages, International Journal of Molecular Sciences 20(1): 66.
- Marques A.R., Willems L.I., Herrera Moro D., Florea B.I., Scheij S., Ottenhof R., Roomen C. van, Verhoek M., Nelson J.K., Kallemeijn W.W., Biela-Banas A., Martin O.R., Cachón-González M.B., Kim N.N., Cox T.M., Boot R.G., Overkleeft H.S. & Aerts J.M.F.G. (2017), A specific activity-based probe to monitor family GH59 galactosylceramidase - the enzyme deficient in Krabbe disease, ChemBioChem 18(4): 402-412.
- Kytidou K., Beenakker T.J.M., Westerhof L.B., Hokke C.H., Moolenaar G.F., Goosen N., Mirzaian M., Guimaraes da Lomba Ferraz M.J., Geus M.A.R. de, Kallemeijn W.W., Overkleeft H.S., Boot R.G., Schots A., Bosch D. & Aerts J.M.F.G. (2017), Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease, Frontiers in Plant Science 8: 1026.
- Lahav D., Liu B., Berg R.J.B.H.N. van den, Nieuwendijk A.M.C.H. van den, Wennekes T., Ghisaidoobe A.T., Breen I., Ferraz M.J., Kuo C.L., Wu L., Geurink P.P., Ovaa H., Marel G.A. van der, Stelt M. van der, Boot R.G., Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2017), A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase, Journal of the American Chemical Society 138(40): 14192-14197.
- Ben Bdira F., Kallemeijn W.W., Oussoren S.V., Scheij S., Bleijlevens B., Florea B.I., Roomen C.P.A.A. van, Ottenhoff R., Kooten M.J.F.M. van, Walvoort M.T.C., Witte M.D., Boot R.G., Ubbink M., Overkleeft H.S. & Aerts J.M.F.G. (2017), Stabilization of Glucocerebrosidase by Active Site Occupancy, ACS Chemical Biology 12(7): 1830-1841.
- Jiang J., Kuo C.L., Wu L., Franke C., Kallemeijn W.W., Florea B.I., Meel H.M.M. van, Marel G.A. van der, Codee J.D.C., Boot R.G., Davies G.J., Overkleeft H.S. & Aerts J.M.F.G. (2017), Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes", ACS Central Science 3(6): 673.
- Kallemeijn W.W., Scheij S., Hoogendoorn S., Witte M.D., Herrera Moro Chao D., Roomen C.P.A.A. van, Ottenhoff R., Overkleeft H.S., Boot R.G. & Aerts J.M.F.G. (2017), Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes, PLoS ONE 12(2): e0170268.
- Aerts J.M.F.G., Guimaraes da Lomba Ferraz M.J., Mirzaian M., Gaspar P., Oussoren S.V., Wisse P., Kuo C.L., Lelieveld L.T., Kytidou K., Hazeu M.D., Boer D.E.C., Meijer R., Lienden M.J.C. van der, Herrera D., Gabriel T.L., Aten J., Overkleeft H.S., Eijk M.C. van, Boot R.G. & Rosa Alcalde Marques A. (2017), Lysosomal Storage Diseases. For Better or Worse: Adapting to Defective Lysosomal Glycosphingolipid Breakdown. In: , eLS. eLS: John Wiley & Sons, Ltd.. 1-13.
- James A.J., Reinius L.E., Verhoek M., Gomes A., Kupczyk M., Hammar U., Ono J., Ohta S., Izuhara K., Bel E., Kere J., Soderhall C., Dahlen B., Boot R.G. & Dahlen S.-E. (2016), Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease, American Journal of Respiratory and Critical Care Medicine 193(2): 131-142.
- Marques A.R., Mirzaian M., Akiyama H., Wisse P., Ferraz M.J., Gaspar P., Ghauharali-Van der Vlugt K., Meijer R., Giraldo P., Alfonso P., Irún P., Dahl M., Karlsson S., Pavlova E.V., Cox T.M., Scheij S., Verhoek M., Ottenhoff R., Roomen C.P. van, Pannu N.S., Van Eijk M., Dekker N., Boot R.G., Overkleeft H.S., Blommaart E., Hirabayashi Y. & Aerts J.M. (2016), Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases, 57: 451-463.
- Kallemeijn W.W., Scheij S., Voorn-Brouwer T.M., Witte M.D., Verhoek M., Overkleeft H.S., Boot R.G. & Aerts J.M. (2016), Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement, ChemBioChem 17(18): 1698-1704.
- Guimaraes da Lomba Ferraz M.J., Marques A.R., Appelman M.D., Verhoek M., Strijland A., Mirzaian M., Scheij S., Ouairy C.M.J., Lahav D., Wisse P., Overkleeft H.S., Boot R.G. & Aerts J.M.F.G. (2016), Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases, FEBS Letters 590(6): 716-725.
- Kramer G., Wegdam W., Donker-Koopman W., Ottenhoff R., Gaspar P., Verhoek M., Nelson J., Gabriel T., Kallemeijn W.W., Boot R.G., Laman J.D., Vissers J.P., Cox T., Pavlova E., Moran M.T., Aerts J.M.F.G. & Eijk M.C. van (2016), Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models, FEBS Open Bio 6(9): 902-913.
- Jiang J., Kuo C.L., Wu L., Franke C., Kallemeijn W.W., Florea B.I., Meel H.M.M. van, Marel G.A. van der, Codée J.D.C., Boot R.G., Davies G.J., Overkleeft H.S. & Aerts J.M.F.G. (2016), Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes, ACS Central Science 2(5): 351-358.
- Herrera Moro Chao D., Argmann C., Eijk M. van, Boot R.G., Ottenhoff R., Roomen C. van, Foppen E., Siljee J.E., Unmehopa U.A., Kalsbeek A. & Aerts J.M.F.G. (2016), Impact of obesity on taste receptor expression in extra-oral tissues: emphasis on hypothalamus and brainstem, Scientific Reports 6: 29094.
- Ben Bdira F., Jiang J., Kallemeijn W.W., Haan A. de, Florea B.I., Bleijlevens B., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Ubbink M. (2016), Hydrophobic interactions contribute to conformational stabilization of endoglycoceramidase II by mechanism-based probes, Biochemistry 55(34): 4823-4835.
- Ouairy C.M.J., Ferraz M.J., Boot R.G., Baggelaar M.P., Stelt M. van der, Appelman M., Marel G.A. van der, Florea B.I., Aerts J.M.F.G. & Overkleeft H.S. (2015), Development of an acid ceramidase activity-based probe, Chemical Communications 51(28): 6161-6163.
- Mirzaian M., Wisse P., Ferraz M.J., Gold H., Donker-Koopman W.E., Verhoek M., Overkleeft H.S., Boot R.G., Kramer G., Dekker N. & Aerts J.M.F.G. (2015), Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard, Blood Cells, Molecules and Diseases 54(4): 307-314.
- Chao D.H.M., Kallemeijn W.W., Marques A.R.A., Orre M., Ottenhoff R., Roomen C. van, Foppen E., Renner M.C., Moeton M., Eijk M. van, Boot R.G., Kamphuis W., Hol E.M., Aten J., Overkleeft H.S., Kalsbeek A. & Aerts J.M.F.G. (2015), Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes, PLoS ONE 10(9): e0138107.
- Marques A.R.A., Aten J., Ottenhoff R., Roomen C.P.A.A. van, Moro D.H., Claessen N., Veloz M.F.V., Zhou K., Lin Z., Mirzaian M., Boot R.G., Zeeuw C.I. de, Overkleeft H.S., Yildiz Y. & Aerts J.M.F.G. (2015), Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice, PLoS ONE 10(8): e0135889.
- Jiang J., Kallemeijn W.W., Wright D.W., Nieuwendijk A.M.C.H. van den, Coco Rohde V., Folch E.C., Elst H. van den, Florea B.I., Scheij S., Donker-Koopman W.E., Verhoek M., Li N., Schürmann M., Mink D., Boot R.G., Codée J.D.C., Marel G.A. van der, Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2015), In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 alpha-L-fucosidases, Chemical Science 6(5): 2782-2789.
- Jebbink J.M., Boot R.G., Keijser R., Moerland P.D., Aten J., Veenboer G.J.M., Wely M. van, Buimer M., Ver Loren van Themaat E., Aerts J.M.F.G., Post J.A.M. van der, Afink G.B. & Ris-Stalpers C. (2015), Increased glucocerebrosidase expression and activity in preeclamptic placenta, Placenta 36(2): 160-169.
- Kallemeijn W.W., Witte M.D., Voorn-Brouwer T.M., Walvoort M.T.C., Li K.Y., Codee J.D.C., Marel G.A. van der, Boot R.G., Overkleeft H.S. & Aerts J.M.F.G. (2014), A Sensitive Gel-Based Method Combining Distinct Cyclophellitol-Based Probes for the Identification of Acid/Base Residues in Human Retaining Beta-Glucosidases, Journal of Biological Chemistry 289(51): 35351-35362.
- Guimaraes da Lomba Ferraz M.J., Kallemeijn W.W., Mirzaian M., Herrera Moro D., Marques A., Wisse P., Boot R.G., Willems L.I., Overkleeft H.S. & Aerts J.M.F.G. (2014), Gaucher disease and Fabry disease: New markers and insights in pathophysiology for two distinct glycosphingolipidoses, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841(5): 811-825.
- Duivenvoorden B.A., Ghauharali K., Scheij S., Boot R.G., Aerts J.M.F.G., Marel G.A. van der, Overkleeft H.S. & Codee J.D.C. (2014), Design and synthesis of 4 '-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates, Carbohydrate Research 399: 26-37.
- Li K.Y., Jiang J., Witte M.D., Kallemeijn W.W., Donker-Koopman W.E., Boot R.G., Aerts J.M.F.G., Codee J.D.C., Marel G.A. van der & Overkleeft H.S. (2014), Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors, 12(39): 7786-7791.
- Willems L.I., Beenakker T.J.M., Murray B., Scheij S., Kallemeijn W.W., Boot R.G., Verhoek M., Donker-Koopman W.E., Guimaraes da Lomba Ferraz M.J., Rijssel E.R. van, Florea B.I., Codee J.D.C., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2014), Potent and Selective Activity-Based Probes for GH27 Human Retaining alpha-Galactosidases, Journal of the American Chemical Society 136(33): 11622-11625.
- Li K.-Y., Kallemeijn W.W., Jiang J., Walvoort M.T.C., Willems L.I., Beenakker T., Elst H. van den, Marel G.A. van der, Codée J.D.C., Aerts J.M.F.G., Florea B.I., Boot R.G., Witte M.D. & Overkleeft H.S. (2014), Rational Design of Activity-Based Retaining β-Exoglucosidase Probes. In: Waldmann H. & Janning P. (Eds.), Concepts and Case Studies in Chemical Biology: Wiley. 191-206.
- Dussen L. van, Hendriks E.J., Groener J.E.M., Boot R.G., Hollak C.E.M. & Aerts J.M.F.G. (2014), Value of plasma chitotriosidase to assess non-neuronopathic Gaucher disease severity and progression in the era of enzyme replacement therapy, Journal of Inherited Metabolic Disease 37(6): 991-1001.
- Aerts J.M.F.G., Guimaraes da Lomba Ferraz M.J., Boot R.G., Breemen M.J. van, Dekker N., Kramer G., Hollak C.E.M., Maas M., Linthorst G.E., Smid B., Rombach S.M., Dussen L. van, Poorthuis B. & Groener J.E.M. (2013), Biomarkers for lysosomal storage disorders. In: Surendran S. (Ed.), Neurochemistry of metabolic diseases: lysosomal storage diseases, phenylketonuria, and Canavan disease. Hauppage, NY: Nova Science Publishers. 169-202.
- Konradsen J.R., James A., Nordlund B., Reinius L.E., Söderhäll C., Melén E., Wheelock A.M., Lödrup C.K.C., Lidegran M., Verhoek M., Boot R.G., Dahlén B., Dahlén S.E. & Hedlin G. (2013), The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma, Journal of Allergy and Clinical Immunology 132(2): 328-35.e5.
- Nieuwendijk A.M.C.H. van den, Berg R.J.B.H.N. van den, Ruben M., Witte M.D., Brussee J., Boot R.G., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2012), Synthesis of Eight 1-Deoxynojirimycin Isomers from a Single Chiral Cyanohydrin, European Journal of Organic Chemistry 2012(18): 3437-3446.
- Lo S.M., Choi M., Liu J., Jain D., Boot R.G., Kallemeijn W.W., Aerts J.M.F.G., Pashankar F., Kupfer G.M., Mane S., Lifton R.P. & Mistry P.K. (2012), Phenotype diversity in type 1 Gaucher disease: discovering the genetic basis of Gaucher disease/hematologic malignancy phenotype by individual genome analysis, Blood 119(20): 4731-4740.
- Kallemeijn W.W., Li K.Y., Witte M.D., Marques A.R.A., Aten J., Scheij S., Jiang J., Willems L.I., Voorn-Brouwer T.M., Roomen C.P.A.A. van, Ottenhoff R., Boot R.G., Elst H. van den, Walvoort M.T.C., Florea B.I., Codee J.D.C., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2012), Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie (International Edition) 51(50): 12529-12533.
- Aureli M., Bassi R., Loberto N., Regis S., Prinetti A., Chigorno V., Aerts J.M.F.G., Boot R.G., Filocamo M. & Sonnino S. (2012), Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts, Journal of Inherited Metabolic Disease 35(6): 1081-1091.
- Witte M.D., Walvoort M.T.C., Li K.Y., Kallemeijn W.W., Donker-Koopman W.E., Boot R.G., Aerts J.M.F.G., Codee J.D.C., Marel G.A. van der & Overkleeft H.S. (2011), Activity-Based Profiling of Retaining beta-Glucosidases: A Comparative Study, ChemBioChem 12(8): 1263-1269.
- Ghisaidoobe A., Bikker P., Bruijn A.C.J. de, Godschalk F.D., Rogaar E., Guijt M.C., Hagens P., Halma J.M., Hart S.M. van 't, Luitjens S.B., Rixel V.H.S. van, Wijzenbroek M., Zweegers T., Donker-Koopman W.E., Strijland A., Boot R.G., Marel G.A. van der, Overkleeft H.S., Aerts J.M.F.G. & Berg R.J.B.H.N. van den (2011), Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars, ACS Medicinal Chemistry Letters 2(2): 119-123.
- Dekker N., Dussen L. van, Hollak C.E.M., Overkleeft H., Scheij S., Ghauharali K., Breemen M.J. van, Ferraz M.J., Groener J.E.M., Maas M., Wijburg F.A., Speijer D., Tylki-Szymanska A., Mistry P.K., Boot R.G. & Aerts J.M.F.G. (2011), Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response, Blood 118(16): e118-27.
- Smid B.E., Aerts J.M.F.G., Boot R.G., Linthorst G.E. & Hollak C.E. (2011), Pharmacological small molecules for the treatment of lysosomal storage disorders, Expert Opinion on Investigational Drugs 19(11): 1367-1379.
- Dekker N., Voorn-Brouwer T., Verhoek M., Wennekes T., Narayan R.S., Speijer D., Hollak C.E.M., Overkleeft H.S., Boot R.G. & Aerts J.M.F.G. (2011), The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation, Blood Cells, Molecules and Diseases 46(1): 19-26.
- Aerts J.M.F.G., Boot R.G., Eijk M.C. van, Groener J., Bijl N., Lombardo E., Bietrix F.M., Dekker N., Groen A.K., Ottenhoff R., Roomen C. van, Aten J., Serlie M., Langeveld M., Wennekes T. & Overkleeft H.S. (2011), Glycosphingolipids and insulin resistance. In: Cowart L.A. (Ed.), Sphingolipids and Metabolic Disease. Advances in Experimental Medicine and Biology no. 721. New York, NY, U.S.A.: Springer. 20-41.
- Berg R.J.B.H.N. van den, Wennekes T., Ghisaidoobe A., Donker-Koopman W.E., Strijland A., Boot R.G., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2011), Assessment of Partially Deoxygenated Deoxynojirimycin Derivatives as Glucosylceramide Synthase Inhibitors, ACS Medicinal Chemistry Letters 2(7): 519-522.
- Aerts J.M.F.G., Kallemeijn W.W., Wegdam W., Joao Ferraz M., Van Breemen M.J., Dekker N., Kramer G., Poorthuis B.J., Groener J.E.M., Cox-Brinkman J., Rombach S.M., Hollak C.E.M., Linthorst G.E., Witte M.D., Gold H., Marel G.A. van der, Overkleeft H.S. & Boot R.G. (2011), Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies, Journal of Inherited Metabolic Disease 34(3): 605-619.
- Gold H., Boot R.G., Aerts J.M.F.G., Overkleeft H.S., Codee J.D.C. & Marel G.A. van der (2011), A Concise Synthesis of Globotriaosylsphingosine, European Journal of Organic Chemistry (9): 1652-1663.
- Aerts J.M.F.G., Boot R.G., Eijk M.C. van, Groener J., Bijl N., Lombardo E., Bietrix F.M., Dekker N., Groen A.K., Ottenhoff R., Roomen C. van, Aten J., Serlie M., Langeveld M., Wennekes T. & Overkleeft H.S. (2011), Glycosphingolipids and insulin resistance, Advances in Experimental Medicine and Biology 721: 99-119.
- Smid B.E., Aerts J. M.F.G., Boot R.G., Linthorst G.E. & Hollak C.E.M. (2010), Pharmacological small molecules for the treatment of lysosomal storage disorders, Expert Opinion on Investigational Drugs 19(11): 1367-1379.
- Eijk M.C. van, Aust G., Brouwer M.S.M., Meurs M. van, Voerman J.S.A., Dijke I.E., Pouwels W., Saendig I., Wandel E., Aerts J.M.F.G., Boot R.G., Laman J.D. & Hamann J. (2010), Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease, Immunology Letters 129(2): 64-71.
- Eijk M.C. van, Voorn-Brouwer T., Scheij S.S., Verhoeven A.J., Boot R.G. & Aerts J.M.F.G. (2010), Curdlan-mediated regulation of human phagocyte-specific chitotriosidase, FEBS Letters 584(14): 3165-3169.
- Wennekes T., Meijer A.J., Groen A.K., Boot R.G., Groener J.E., Eijk M.C. van, Ottenhoff R., Bijl N., Ghauharali K., Song H., O'Shea T.J., Liu H., Yew N., Copeland D., Berg R.J.B.H.N. van den, Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2010), Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation, Journal of Medicinal Chemistry 53(2): 689-698.
- Witte M.D., Kallemeijn W.W., Aten J., Li K.Y., Strijland A., Donker-Koopman W.E., Nieuwendijk A.M.C.H. van den, Bleijlevens B., Kramer G., Florea B.I., Hooibrink B., Hollak C.E.M., Ottenhoff R., Boot R.G., Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2010), Ultrasensitive in situ visualization of active glucocerebrosidase molecules, Nature Chemical Biology 6(12): 907-913.
- Boot R.G., Hollak C.E.M., Verhoek M., Alberts C., Jonkers R.E. & Aerts J.M.F.G. (2010), Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis, Clinica Chimica Acta 411(1-2): 31-36.
- Dinkelaar J., Duivenvoorden B.A., Wennekes T., Overkleeft H.S., Boot R.G., Aerts J.M.F.G., Codee J.D.C. & Van der Marel G.A. (2010), A Preparative Synthesis of Human Chitinase Fluorogenic Substrate (4'-Deoxychitobiosyl)-4-methylumbelliferone, European Journal of Organic Chemistry (13): 2565-2570.
- Nieuwendijk A.M.C.H. van, Ruben M., Engelsma S.E., Risseeuw M.D.P., Berg R.J.B.H.N. van den, Boot R.G., Aerts J.M.F.G., Brussee J., Marel G.A. van der & Overkleeft H.S. (2010), Synthesis of L-altro-1-Deoxynoprimycin, D-allo-1-Deoxynoprimycin, and D-galacto-1-Deoxynojirimycin from a Single Chiral Cyanohydrin, 12(17): 3957-3959.
- Bijl N., Sokolovic M., Vrins C., Langeveld M., Moerland P.D., Ottenhoff R., Roomen C.P.A.A. van, Claessen N., Boot R.G., Aten J., Groen A.K., Aerts J.M.F.G. & Eijk M.C. van (2009), Modulation of Glycosphingolipid Metabolism Significantly Improves Hepatic Insulin Sensitivity and Reverses Hepatic Steatosis in Mice, Hepatology 50(5): 1431-1441.
- Boot R.G., Breemen M.J. van, Wegdam W., Sprenger R.R., Jong S. de, Speijer D., Hollak C.E.M., Dussen L. van, Hoefsloot H.C.J., Smilde A.K., Koster C.G. de, Vissers J.P.C. & Aerts J.M.F.G. (2009), Gaucher disease: a model disorder for biomarker discovery, 6(4): 411-419.
- Bussink A.P., Verhoek M., Vreede J., Ghauharali-Van der Vlugt K., Donker-Koopman W.E., Sprenger R.R., Hollak C.E., Aerts J.M.F.G. & Boot R.G. (2009), Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates, FEBS Journal 276(19): 5678-5688.
- Ghauharali-Van der Vlugt K., Bussink A.P., Groener J.E.M., Boot R.G. & Aerts J.M.F.G. (2009), Detection of chitinase activity by 2-aminobenzoic acid labeling of chito-oligosaccharides, Analytical Biochemistry 384(1): 191-193.
- Wennekes T., Berg R.J.B.H.N. van den, Boot R.G., Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2009), Glycosphingolipids-Nature, Function, and Pharmacological Modulation, Angewandte Chemie (International Edition) 48(47): 8848-8869.
- Bijl N., Roomen C.P.A.A. van, Triantis V., Sokolovic M., Ottenhoff R., Scheij S., Eijk M. van, Boot R.G., Aerts J.M.F.G. & Groen A.K. (2009), Reduction of Glycosphingolipid Biosynthesis Stimulates Biliary Lipid Secretion In Mice, Hepatology 49(2): 637-645.
- Breemen M.J. van, Fost M. de, Maas M., Wiersma M.G., Hollak C.E.M., Poll L.W., Vom Dahl S., Boot R.G. & Aerts J.M.F.G. (2009), Different dose-dependent correction of MIP-1 beta and chitotriosidase during initial enzyme replacement therapy, Journal of Inherited Metabolic Disease 32(2): 274-279.
- Seibold M.A., Reese T.A., Choudhry S., Salam M.T., Beckman K., Eng C., Atakilit A., Meade K., Lenoir M., Watson H.G., Thyne S., Kumar R., Weiss K.B., Grammer L.C., Avila P., Schleimer R.P., Fahy J.V., Rodriguez-Santana J., Rodriguez-Cintron W., Boot R.G., Sheppard D., Gilliland F.D., Locksley R.M. & Burchard E.G. (2009), Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein, Journal of Biological Chemistry 284(29): 19650-19658.
- Boot R.G., Speijer D., Bussink A.P. & Aerts J.M.F.G. (2009), The origin and genetics of human chitinases. In: Musumeci S. & Paoletti M.G. (Eds.), Binomium chitin-chitinase : recent issues. Hauppage, NY: Nova Science Publishers. 77-99.
- Aerts J.M.F.G. & Boot R.G. (2009), The Gaucher cell and chitotriosidase, the phagocyte chitinase. In: Musumeci S. & Paoletti M.G. (Eds.), Binomium Chitin-Chitinase: recent issues. Hauppage, NY: Nova Science Publishers. 113-128.
- Bussink A.P., Vreede J., Aerts J.M.F.G. & Boot R.G. (2008), A single histidine residue modulates enzymatic activity in acidic mammalian chitinase, FEBS Letters 582(6): 931-935.
- Seibold M.A., Donnelly S., Solon M., Innes A., Woodruff P.G., Boot R.G., Burchard E.G. & Fahy J.V. (2008), Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit, Journal of Allergy and Clinical Immunology 122(5): 944-950.
- Fost M. de, Out T.A., Wilde F.A. de, Tjin E.P.M., Pals S.T., Oers M.H.J. van, Boot R.G., Aerts J.F.M.G., Maas M., Dahl S. vom & Hollak C.E.M. (2008), Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature, Annals of Hematology 87(6): 439-449.
- Aerts J.M.F.G., Breemen M.J. van, Bussink A.P., Ghauharali K., Sprenger R., Boot R.G., Groener J.E., Hollak C.E., Maas M., Smit S., Hoefsloot H.C., Smildel A.K., Vissers J.P.C., Jong S. de, Speijer D. & Koster C.G. de (2008), Biomarkers for lysosomal storage disorders: identification and application as exemplified by chitotriosidase in Gaucher disease, Acta Paediatrica: Nurturing the Child 97(s457): 7-14.
- Bijl N., Scheij S., Houten S., Boot R.G., Groen A.K. & Aerts J.M.F.G. (2008), The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells, Journal of Pharmacology and Experimental Therapeutics 326(3): 849-855.
- Aerts J.M.F.G., Groener J.E., Kuiper S., Donker-Koopman W.E., Strijland A., Ottenhoff R., Roomen C. van, Mirzaian M., Wijburg F.A., Linthorst G.E., Vedder A.C., Rombach S.M., Cox-Brinkman J., Somerharju P., Boot R.G., Hollak C.E., Brady R.O. & Poorthuis B.J. (2008), Elevated globotriaosylsphingosine is a hallmark of Fabry disease, Proceedings of the National Academy of Sciences 105(8): 2812-2817.
- Eijk M.C. van, Scheij S.S., Roomen C.P.A.A. van, Speijer D., Boot R.G. & Aerts J.M.F.G. (2007), TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase, FEBS Letters 581(28): 5389-5395.
- Aerts J.M.F.G. & Boot R.G. (2007), Beyond the primary biochemical defect in type 1 Gaucher disease, Clinical Therapeutics 29(Supplement C): S77-S78.
- Bussink A.P., Swieten P.F. van, Ghauharali K., Scheij S., Eijk M.C. van, Wennekes T., Marel G.A. van der, Boot R.G., Aerts J.M.F.G. & Overkleeft H.S. (2007), N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides, Journal of Lipid Research 48(6): 1417-1421.
- Bussink A.P., Speijer D., Aerts J.M.F.G. & Boot R.G. (2007), Evolution of mammalian chitinase (-like) members of family 18 glycosyl hydrolases, Genetics 177(2): 959-970.
- Breemen M.J. van, Fost M. de, Voerman J.S.A., Laman J.D., Boot R.G., Maas M., Hollak C.E.M., Aerts J.M.F.G. & Rezaee F. (2007), Increased plasma macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta levels in type 1 Gaucher disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1772(7): 788-796.
- Boot R.G., Verhoek M., Donker-Koopman W., Strijland A., Marle J. van, Overkleeft H.S., Wennekes T. & Aerts J.M.F.G. (2007), Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2, Journal of Biological Chemistry 282(2): 1305-1312.
- Boot R.G., Verhoek M., Langeveld M., Renkema G.H., Hollak C.E.M., Weening J.J., Donker-Koopman W.E., Groener J.E. & Aerts J.M.F.G. (2006), CCL18: A urinary marker of Gaucher cell burden in Gaucher patients, Journal of Inherited Metabolic Disease 29(4): 564-571.
- Aerts J.M.F.G., Hollak C.E.M., Boot R.G., Groener J.E.M. & Maas M. (2006), Substrate reduction therapy of glycosphingolipid storage disorders, Journal of Inherited Metabolic Disease 29(2-3): 449-456.
- Bussink A.P., Eijk M. van, Renkema G.H., Aerts J.M.F.G. & Boot R.G. (2006), The biology of the Gaucher cell: The cradle of human chitinases, International Review of Cytology 252: 71-128.
- Boven L.A., Meurs M. van, Zwam M. van, Wierenga-Wolf A., Hintzen R.Q., Boot R.G., Aerts J.M.F.G., Amor S., Nieuwenhuis E.E. & Laman J.D. (2006), Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis, Brain 129((Part 2)): 517-526.
- Rao F.V., Houston D.R., Boot R.G., Aerts J.M.F.G., Hodkinson M., Adams D.J., Shiomi K., Omura S. & Aalten D.M.F. van (2005), Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases, Chemistry & Biology 12(1): 65-76.
- Boot R.G., Bussink A.P., Verhoek M., Boer P.A.J. de, Moorman A.F.M. & Aerts J.M.F.G. (2005), Marked differences in tissue-specific expression of chitinases in mouse and man, Journal of Histochemistry and Cytochemistry 53(10): 1283-1292.
- Aerts J.M.F.G., Hollak C.E.M., Breemen M. van, Maas M., Groener J.E.M. & Boot R.G. (2005), Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases, Acta Paediatrica: Nurturing the Child 94(s447): 43-46.
- Boot R.G., Bussink A.P. & Aerts J.M.F.G. (2005), Human acidic mammalian chitinase erroneously known as eosinophil chemotactic cytokine is not the ortholog of mouse YM1, Journal of Immunology 175(4): 2041-2042.
- Deegan P.B., Moran M.T., McFarlane I., Schofield J.P., Boot R.G., Aerts J.M.F.G. & Cox T.M. (2005), Clinical evaluation of chemokine and enzymatic biomarkers of Gaucher disease, Blood Cells, Molecules and Diseases 35(2): 259-267.
- Eijk M.C. van, Roomen C.P.A.A. van, Renkema G.H., Bussink A.P., Andrews L., Blommaart E.F.C., Sugar A., Verhoeven A.J., Boot R.G. & Aerts J.M.F.G. (2005), Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity, International Immunology 17(11): 1505-1512.
- Dimitriou E., Verhoek M., Altun S., Karabatsos F., Moraitou M., Youssef J., Boot R.G., Sarafidou J., Karagiorga M., Aerts J.M.F.G. & Michelakakis H. (2005), Elevated plasma chemokine CCL18/PARC in beta-thalassemia, Blood Cells, Molecules and Diseases 35(3): 328-331.
- Brinkman J., Wijburg F.A., Hollak C.E., Groener J.E., Verhoek M., Scheij S., Aten J., Boot R.G. & Aerts J.M.F.G. (2005), Plasma chitotriosidase and CCL18: Early biochemical surrogate markers in type B Niemann-Pick disease, Journal of Inherited Metabolic Disease 28(1): 13-20.
- Hollak C.E.M., Boot R.G., Poorthuis B.J.H.M. & Aerts J.M.F.G. (2005), Van gen naar ziekte; de ziekte van Gaucher, Nederlands Tijdschrift voor Geneeskunde 149: 2163-2166.
- Boot R.G., Verhoek M., Fost M. de, Hollak C.E.M., Maas M., Bleijlevens B., Breemen M.J. van, Meurs M. van, Boven L.A., Laman J.D., Moran M.T., Cox T.M. & Aerts J.M.F.G. (2004), Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention, Blood 103(1): 33-39.
- Boven L.A., Meurs M. van, Boot R.G., Mehta A., Boon L., Aerts J.M.F.G. & Laman J.D. (2004), Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages, American Journal of Clinical Pathology 122(3): 359-369.
- Rao F.V., Houston D.R., Boot R.G., Aerts J.M.F.G., Sakuda S. & Aalten D.M.F. van (2003), Crystal structures of allosamidin derivatives in complex with human macrophage chitinase, Journal of Biological Chemistry 278(22): 20110-20116.
- Aguilera B., Ghauharali-Van der Vlugt K., Helmond M.T.J., Out J.M.M., Donker-Koopman W.E., Groener J.E.M., Boot R.G., Renkema G.H., Marel G.A. van der, Boom J.H. van, Overkleeft H.S. & Aerts J.M.F.G. (2003), Transglycosidase activity of chitotriosidase - Improved enzymatic assay for the human macrophage chitinase, Journal of Biological Chemistry 278(42): 40911-40916.
- Groener J.E.M., Hollak C.E.M., Bakker H.D., Boot R.G. & Aerts J.M.F.G. (2003), Behandeling van patiënten met de ziekte van Gaucher aan de hand van chemische ziektemarkers, Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde 28: 352-355.
- Aerts J.M.F.G., Hollak C., Boot R.G. & Groener A. (2003), Biochemistry of glycosphingolipid storage disorders: implications for therapeutic intervention, Philosophical Transactions of the Royal Society B: Biological Sciences 358(1433): 905-914.
- Aerts J.M.F.G., Hollak C.E.M., Boot R.G. & Groener A. (2003), Macrophages as therapeutic targets in lysosomal storage disorders. In: Gordon S. (Ed.), The macrophage as therapeutic target. Handbook of Experimental Pharmacology no. 158. Berlin, Heidelberg: Springer. 193-208.
- Fusetti F., Moeller H. von, Houston D., Rozeboom H.J., Dijkstra B.W., Boot R.G., Aerts J.M.F.G. & Aalten D.M.F. van (2002), Structure of human chitotriosidase - Implications for specific inhibitor design and function of mammalian chitinase-like lectins, Journal of Biological Chemistry 277(28): 25537-25544.
- Boot R.G., Blommaart E.F.C., Swart E., Ghauharali-Van der Vlugt K., Bijl N., Moe C., Place A. & Aerts J.M.F.G. (2001), Identification of a novel acidic mammalian chitinase distinct from chitotriosidase, Journal of Biological Chemistry 276(9): 6770-6778.
- Boot R.G., Achterberg T.A.E. van, Aken B.E. van, Renkema G.H., Jacobs M.J.H.M., Aerts J.M.F.G. & Vries C.J.M. de (1999), Strong induction of members of the chitinase family of proteins in atherosclerosis - Chitotriosidase and human cartilage gp-39 expressed in lesion macrophages, Arteriosclerosis, Thrombosis, and Vascular Biology 19(3): 687-694.
- Boot R.G., Renkema G.H., Verhoek M., Strijland A., Bliek J., Meulemeester T.M.A.M.O. de, Mannens M.M.A.M. & Aerts J.M.F.G. (1998), The human chitotriosidase gene - Nature of inherited enzyme deficiency, Journal of Biological Chemistry 273(40): 25680-25685.
- Renkema G.H., Boot R.G., Au F.L., Donker-Koopman W.E., Strijland A., Muijsers A.O., Hrebicek M. & Aerts J.M.F.G. (1998), Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages, European Journal of Biochemistry 251(1-2): 504-509.
- Renkema G.H., Boot R.G., Strijland A., Donker-Koopman W.E., Berg M. van den, Muijsers A.O. & Aerts J.M.F.G. (1997), Synthesis, sorting, and processing into distinct isoforms of human macrophage chitotriosidase, European Journal of Biochemistry 244(2): 279-285.
- Boot R.G., Hollak C.E.M., Verhoek M., Sloof P., Poorthuis B.J.H.M., Kleijer W.J., Wevers R.A., Oers M.H.J. van, Mannens M.M.A.M., Aerts J.M.F.G. & Weely S. van (1997), Glucocerebrosidase genotype of Gaucher patients in The Netherlands: Limitations in prognostic value, Human Mutation 10(5): 348-358.
- Aerts J.M.F.G., Boot R.G., Renkema G.H., Weely S. van, Hollak C.E.M., Donker-Koopman W.E., Strijland A. & Verhoek M. (1996), Chitotriosidase: a human macrophage chitinase that is a marker for Gaucher disease manifestation. Muzzarelli R.A.A. (Ed.), Chitin Enzymology. 2nd International Symposium on Chitin Enzymology 8 May 1996 - 11 May 1996 no. 2. Ancona: Atec. 3-10.
- Renkema G.H., Boot R.G., Muijsers A.O., Donker-Koopman W.E. & Aerts J.M.F.G. (1995), Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins, Journal of Biological Chemistry 270(5): 2198-2202.
- Aerts J.M.F.G., Boot R.G., Renkema G.H., Weely S. van, Jones S., Hollak C.E.M. & Oers M.H.J. van (1995), Molecular and biochemical abnormalities of Gaucher disease. Chitotriosidase, a newly identified biochemical marker, Seminars in Hematology 32: 10-13.
- Michelakakis H., Dimitriou E., Weely S. van, Boot R.G., Mavridou I., Verhoek M. & Aerts J.M.F.G. (1995), Characterization of glucocerebrosidase in Greek Gaucher disease patients - mutation analysis and biochemical studies, Journal of Inherited Metabolic Disease 18(5): 609-615.
- Boot R.G., Renkema G.H., Strijland A., Zonneveld A.J. van & Aerts J.M.F.G. (1995), Cloning of a cDNA Encoding Chitotriosidase, a Human Chitinase Produced by Macrophages, Journal of Biological Chemistry 270(44): 26252-26256.
- Aerts J.M.F.G., Weely S. van, Boot R., Hollak C.E.M. & Tager J.M. (1993), Pathogenesis of lysosomal storage disorders as illustrated by Gaucher disease, Journal of Inherited Metabolic Disease 16(2): 288-291.
- Leij I. van der, Berg M. van den, Boot R.G., Franse M., Distel B. & Tabak H.F. (1992), Isolation of peroxisome assembly mutants from Saccharomyces cereviseae with differnt morphologies using a novel positive selection procedure, Journal of Cell Biology 119(1): 153-162.