Reinaldus Toes
Professor Experimental Rheumatology
- Name
- Prof.dr. R.E.M. Toes
- Telephone
- +31 71 526 1946
- r.e.m.toes@lumc.nl
- ORCID iD
- 0000-0002-9618-6414
René E.M. Toes is professor of experimental rheumatology and has been the head of the Laboratory for Experimental Rheumatology at the LUMC since 2001. In 2018, he received the Carol Nachmann Prize for Rheumatology, and was awarded the Van Loghem Career Prize by the Dutch Society for Immunology in 2022. In 2021, he was appointed as a member of Academia Europaea. In 2020, he was granted an ERC Advanced Grant. Additionally, he serves as the chair of the scientific advisory board of foundation MS research and is a member of several scientific councils/boards. He is also chairing the Graduate School Council at the LUMC. Professor Toes' research focuses on various aspects of the immunological response underlying rheumatic conditions, such as rheumatoid arthritis.
More information about Reinaldus Toes
René E.M. Toes is professor of experimental rheumatology and has been the head of the Laboratory for Experimental Rheumatology at the LUMC since 2001. In 2018, he received the Carol Nachmann Prize for Rheumatology, and was awarded the Van Loghem Career Prize by the Dutch Society for Immunology in 2022. In 2021, he was appointed as a member of Academia Europaea. In 2020, he was granted an ERC Advanced Grant. Additionally, he serves as the chair of the scientific advisory board of foundation MS research and is a member of several scientific councils/boards. He is also chairing the Graduate School Council at the LUMC. Professor Toes' research focuses on various aspects of the immunological response underlying rheumatic conditions, such as rheumatoid arthritis.
Autoimmune disease
The immune system is crucial for protecting against infections caused by viruses and bacteria. However, sometimes the immune system does not function properly and targets the body's own tissues. This can lead to autoimmune diseases such as rheumatoid arthritis, scleroderma, or Systemic Lupus Erythematosus.
Despite significant improvements in the treatment of many of these diseases in recent times, they still cannot be fully cured or prevented. Patients often suffer greatly from their chronic illness, impacting the way they can lead their lives. The research conducted by Professor Toes' research group focuses on understanding how and why the immune system derails and turns against the body's own tissues, leading to the development of autoimmune diseases. The group also develops methods that specifically target and/or eradicate the auto-reactive immune response. The goal of the research is to comprehend the origins and perpetuation of the autoimmune response underlying (rheumatic) autoimmune conditions. By identifying the causes of disease, the research aims to contribute to earlier and better treatments for rheumatic diseases, with the ultimate objective of curing or even preventing them in the future.
Academic career
René Toes completed his studies in Medical Biology at the Vrije Universiteit in Amsterdam in 1989. In 1991, he began his doctoral research, and in 1996, he earned his Ph.D. from Leiden University. The title of his dissertation was "Modulation of tumoricidal T cell responses against adenovirus-induced tumors." Following this, he worked as a Postdoc at the Leiden University Medical Centre, where he further specialized in the fundamental aspects involved in the generation of T-cell responses. In 1998, he became a Fellow of the Royal Netherlands Academy of Arts and Sciences and worked as a researcher in the department of immunology at the University of Tübingen for a year and a half.
Since 2001, he has been the head of the Laboratory for Experimental Rheumatology at the LUMC. His inaugural lecture took place in 2011 and was titled “Experimentele reumatologie uitgelicht”.
Prizes and honourable appointments
1997 CJ Kok Prize for Innovative basic research, Medical faculty University of Leiden
1998 Fellow of the Royal Netherlands Academy of Arts and Sciences: ““Mechanisms of exogenous antigen-processing for induction of MHC class I-restricted T cell responses”
2003 VIDI-Laureate Dutch Organization for Scientific Research: “T cell-mediated immune regulation in rheumatoid arthritis”
2008 VICI-Laureate Dutch Organization for Scientific Research: “Rheumatoid Arthritis and the Human Leukocyte Antigens: How do they connect?
Professor Experimental Rheumatology
- Faculteit Geneeskunde
- Divisie 2
- Reumatologie
- Neppelenbroek, S.; Blomberg, N.J.; Kampstra, A.S.B.; Hem, J.G.K. van der; Huizinga, T.W.J. & Scherer, H.U. (2024), Autoreactive B cells remain active despite clinical disease control in rheumatoid arthritis, Journal of Autoimmunity 149.
- Stork, E.M.; Rijswijck, D.M.H. van; Schie, K.A. van; Hoek, M.; Kissel, T.; Scherer, H.U.; Huizinga, T.W.J.; Heck, A.J.R.; Toes, R.E.M. & Bondt, A. (2024), Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis, Nature Communications 15(1).
- Volkov, M.; Kampstra, A.S.B.; Schie, K.A.J. van; Mourik, A.G. van; Kwekkeboom, J.C.; Ru, A. de; Veelen, P.A. van; Huizinga, T.W.J.; Toes, R.E.M. & Woude, D. van der (2024), Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response, RMD Open: Rheumatic and Musculoskeletal Diseases 10(3).
- Steiner, G. & Toes, R.E.M. (2024), Autoantibodies in rheumatoid arthritis - rheumatoid factor, anticitrullinated protein antibodies and beyond, Current Opinion in Rheumatology 36(3): 217-224.
- Khidir, S.J.H.; Toes, R.E.M.; Mulligen, E. van & Helm-van Mil, A.H.M. van der (2024), Is tooth extraction as proxy for periodontal disease related to the development of RA? Lessons from a longitudinal study in the at-risk stage of clinically suspect arthralgia, Annals of the Rheumatic Diseases.
- Yaykasli, K.O.; Schie, K.A. van; Toes, R.E.M.; Wuhrer, M.; Koeleman, C.A.M.; Bila, G.; Negrych, N.; Schett, G.; Knopf, J.; Herrmann, M. & Bilyy, R. (2024), Neutrophil depletion changes the N-glycosylation pattern of IgG in experimental murine sepsis, International Journal of Molecular Sciences 25(12).
- Hegedus, J.H. von; Jong, A.J. de; Hoekstra, A.T.; Spronsen, E.; Zhu, W.H.; Cabukusta, B.; Kwekkeboom, J.C.; Heijink, M.; Bos, E.; Berkers, C.R.; Giera, M.A.; Toes, R.E.M. & Ioan-Facsinay, A. (2024), Oleic acid enhances proliferation and calcium mobilization of CD3/CD28 activated CD4+ T cells through incorporation into membrane lipids, European Journal of Immunology.
- Kissel, T.; Derksen, V.F.A.M.; Bentlage, A.E.H.; Koeleman, C.; Hafkenscheid, L.; Woude, D. van der; Wuhrer, M.; Vidarsson, G. & Toes, R.E.M. (2024), N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line, Nature Communications 15(1).
- Woude, D. van der & Toes, R.E.M. (2024), Immune response to post-translationally modified proteins in rheumatoid arthritis, Annals of the Rheumatic Diseases.
- Cope, A.P.; Jasenecova, M.; Vasconcelos, J.C.; Filer, A.; Raza, K.; Qureshi, S.; D'Agostino, M.A.; Mcinnes, I.B.; Isaacs, J.; Pratt, A.G.; Fisher, B.A.; Buckley, C.; Emery, P.; Ho, P.L.E.; Buch, M.H.; Ciurtin, C.; Schaardenburg, D. van; Huizinga, T.; Toes, R.; Georgiou, E.; Kelly, J.; Murphy, C.; Prevost, A.T. & APIPPRA study investigators (2024), Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA), The Lancet 403(10429): 838-849.
- Blomberg, N.; Kwekkeboom, J.; Böhringer, S.; Huizinga, T.; Toes, R. & Scherer, H.U. (2023), ABATACEPT TO SILENCE ANTI-CITRULLINATED PROTEIN ANTIBODY-EXPRESSING B CELLS IN RHEUMATOID ARTHRITIS: THE ASCARA TRIAL, Annals of the Rheumatic Diseases 82: 11-11.
- Beukel, M.D. van den; Wesemael, T.J. van; Hoogslag, A.T.W.; Borggreven, N.; Huizinga, T.W.J.; Helm-van Mil, A.H.M. van der; Toes, R.E.M.; Woude, D. van der & Trouw, L.A. (2023), Antibodies against advanced glycation end-products and malondialdehyde-acetaldehyde adducts identify a new specific subgroup of hitherto patients with seronegative arthritis with a distinct clinical phenotype and an HLA class II association, RMD Open 9(4).
- Holborough-Kerkvliet, M.D.; Mucignato, G.; Moons, S.J.; Psomiadou, V.; Konada, R.S.R.; Pedowitz, N.J.; Pratt, M.R.; Kissel, T.; Koeleman, C.A.M.; Tjokrodirijo, R.T.N.; Veelen, P.A. van; Huizinga, T.; Schie, K.A.J. van; Wuhrer, M.; Kohler, J.J.; Bonger, K.M.; Boltje, T.J. & Toes, R.E.M. (2023), A photoaffinity glycan-labeling approach to investigate immunoglobulin glycan-binding partners, Glycobiology 33(9): 732-744.
- Volkov, M.; Brinkhaus, M.; Schie, K.A. van; Bondt, A.; Kissel, T.; Kooi, E.J. van der; Bentlage, A.E.H.; Koeleman, C.A.M.; Taeye, S.W. de; Derksen, N.I.; Dolhain, R.J.E.M.; Braig-Scherer, U.; Huizinga, T.W.J.; Wuhrer, M.; Toes, R.E.M.; Vidarsson, G. & Woude, D. van der (2023), IgG Fab glycans hinder FcRn-mediated placental transport, The Journal of Immunology 210(2): 158-167.
- Blöchl, C.; Gstöttner, C.; Sénard, T.; Stork, E.M.; Scherer, H.U.; Toes, R.E.M.; Wuhrer, M. & Domínguez-Vega, E. (2023), A robust nanoscale RP HPLC-MS approach for sensitive Fc proteoform profiling of IgG allotypes, Analytica Chimica Acta 1279.
- Reijm, S.; Kwekkeboom, J.C.; Blomberg, N.J.; Suurmond, J.; Woude, D. van der; Toes, R.E.M. & Scherer, H.U. (2023), Autoreactive B cells in rheumatoid arthritis include mainly activated CXCR3+memory B cells and plasmablasts, JCI Insight 8(20).
- Liem, S.I.E.; Neppelenbroek, S.; Fehres, C.M.; Wevers, B.A.; Toes, R.E.M.; Allaart, C.F.; Huizinga, T.W.J.; Scherer, H.U. & Vries-Bouwstra, J.K. de (2023), Progression from suspected to definite systemic sclerosis and the role of anti-topoisomerase I antibodies, RMD Open 9(1).
- Reijm, S.; Kwekkeboom, J.C.; Blomberg, N.J.; Suurmond, J.; Woude, D. van der; Toes, R.E.M. & Scherer, H.U. (2023), Autoreactive B cells in rheumatoid arthritis consist of activated CXCR3+ memory B cells and plasmablasts, bioRxiv .
- Kroos, S.; Halima, M.; Kroon, J.; Woude, D. van der; Meijer, O.C.; Wal, M.D. van de; Verhave, P.S.; Schaaf, M.J.M.; Toes, R.E.M. & Kampstra, A.S.B. (2023), Tramadol/paracetamol treatment attenuates the development of collagen antibody-induced arthritis and interferes with prednisolone treatment in mice, Laboratory Animals.
- He, Y.B.; Ge, C.R.; Moreno-Giro, A.; Xu, B.Z.; Beusch, C.M.; Sandor, K.; Su, J.; Cheng, L.; Lonnblom, E.; Lundqvist, C.; Slot, L.M.; Tong, D.M.; Urbonaviciute, V.; Liang, B.B.; Li, T.T.; Lahore, G.F.; Aoun, M.; Malmstrom, V.; Rispens, T.; Ernfors, P.; Svensson, C.I.; Scherer, H.U.; Toes, R.E.M.; Gjertsson, I.; Ekwall, O.; Zubarev, R.A. & Holmdahl, R. (2023), A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis, Nature Communications 14(1).
- Moel, E.C. de; Trouw, L.A.; Terao, C.; Govind, N.; Tikly, M.; El-Gabalawy, H.; Smolik, I.; Bang, H.; Huizinga, T.W.J.; Toes, R.E.M. & Woude, D. van der (2023), Geo-epidemiology of autoantibodies in rheumatoid arthritis, Arthritis Research and Therapy 25(1).
- Holborough-Kerkvliet, M.D.; Kroos, S.; Wetering, R. van de & Toes, R.E.M. (2023), Addressing the key issue: Antigen-specific targeting of B cells in autoimmune diseases, Immunology Letters 259: 37-45.
- Koers, J.; Sciarrillo, R.; Derksen, N.I.L.; Vletter, E.M.; Fillie-Grijpma, Y.E.; Raveling-Eelsing, E.; Graca, N.A.G.; Leijser, T.; Pas, H.H.; Nijen-Vos, L.L. van; Braham, M.V.J.; Buisman, A.M.; Jong, J. de; Schriek, A.I.; Tio-Gillen, A.P.; Teng, Y.K.O.; Steenhuis, M.; Swaneveld, F.H.; Taeye, S.W. de; Gils, M.J. van; Verschuuren, J.J.G.M.; Rutgers, B.; Heeringa, P.; Horvath, B.; Jacobs, B.C.; Leeuw, K. de; Franssen, C.F.M.; Veyradier, A.; Coppo, P.; Gelderman, K.A.; Ham, D.H.S.M. van; Els, C.A.C.M. van; Woude, D. van der; Huizinga, R.; Huijbers, M.G.; Kuijpers, T.W.; Toes, R.E.M.; Bos, N.A.; Rispens, T. & T2B Consortium (2023), Differences in IgG autoantibody Fab glycosylation across autoimmune diseases, Journal of Allergy and Clinical Immunology 151(6): 1646-1654.
- Wesemael, T.J. van; Reijm, S.; Kawakami, A.; Dorjee, A.L.; Stoeken, G.; Maeda, T.; Kawashiri, S.Y.; Huizinga, T.W.J.; Tamai, M.; Toes, R.E.M. & Woude, D. van der (2023), IgM antibodies against acetylated proteins as a possible starting point of the anti-modified protein antibody response in rheumatoid arthritis, Annals of the Rheumatic Diseases 83(2).
- Koppejan, H.; Beyrend, G.; Hameetman, M.; Abdelaal, T.; Toes, R.E.M. & Gaalen, F.A. van (2023), Spondyloarthritis mass cytometry immuno-monitoring, Clinical Rheumatology 42(9): 2387-2396.
- Liem, S.I.E.; Hoekstra, E.M.; Levarht, E.W.N.; Dorjee, A.L.; Scherer, H.U.; Toes, R.E.M.; Huizinga, T.W.J.; Vries-Bouwstra, J.K. de & Fehres, C.M. (2023), Anti-carbamylated protein antibodies in systemic sclerosis, Arthritis Research and Therapy 25(1).
- Weijsten, M.J. van; Venrooij, K.R.; Lelieveldt, L.P.W.M.; Kissel, T.; Buijtenen, E. van; Dalen, F.J. van; Verdoes, M.; Toes, R.E.M. & Bonger, K.M. (2023), Effect of antigen valency on autoreactive B-cell targeting, Molecular Pharmaceutics 21(2).
- Wortel, C.M.; Liem, S.I.; Leeuwen, N.M. van; Boonstra, M.; Fehres, C.M.; Stoeger, L.; Huizinga, T.W.; Toes, R.E.M.; Vries-Bouwstra, J. de & Scherer, H.U. (2023), Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis, RMD Open 9(3).
- Hughes, C.D.; Ryan, S.E.; Steel, K.J.A.; Beukel, M.D. van den; Trouw, L.A.; Schie, K.A.J. van; Toes, R.E.M.; Menon, B.; Kirkham, B.W. & Taams, L.S. (2023), Type 17-specific immune pathways are active in early spondyloarthritis, RMD Open 9(4).
- Liem, S.I.E.; Neppelenbroek, S.; Fehres, C.M.; Wortel, C.; Toes, R.E.M.; Huizinga, T.W.J.; Scherer, H.U. & Vries-Bouwstra, J.K.D. (2023), Autoreactive B cell responses targeting nuclear antigens in systemic sclerosis, Seminars in Arthritis and Rheumatism 58.
- Reijm, S.; Kwekkeboom, J.; Blomberg, N.; Suurmond, J.; Woude, D. van der; Toes, R. & Scherer, H.U. (2023), AUTOREACTIVE B CELLS IN RHEUMATOID ARTHRITIS ARE RECENTLY ACTIVATED AND SHOW LARGE EXPANSIONS OF CXCR3+ANTIBODY-SECRETING CELLS, Annals of the Rheumatic Diseases 82: 208-208.
- Bierling, T.; Gumann, A.; Ottmann, S.; Schulz, S.; Schie, K. van; Weckwerth, L.; Wichert, M.; Kuwert, F.; Hauke, M.; Freudenreich, T.; Toes, R.; Mielenz, D.; Jack, H. & Pracht, K. (2023), Regulation of the humoral immune response by glucose, European Journal of Immunology 53: 138-138.
- Wesemael, T. van; Borgers, J.; Gelderman, K.; Verdegaal, E.; Korse, C.M.; Welters, M.J.P.; Kapiteijn, E.; Houdt, W.J. van; Burg, S. van der; Toes, R.; Thienen, J.V.; Haanen, J. & Woude, D. van der (2023), Autoantibody-positivity Before Treatment Is Associated with Immune-related Adverse Events in Melanoma Patients Treated with anti-PD-1, Arthritis & Rheumatology 75: 4977-4979.
- Cope, A.; Jasenecova, M.; Vasconcelos, J.; Filer, A.; Raza, K.; Qureshi, S.; D'Agostino, M.A.; McInnes, I.; Isaacs, J.; Pratt, A.; Fisher, B.A.; Buckley, C.; Emery, P.; Ho, P.; Buch, M.; Ciurtin, C.; Toes, R.; Huizinga, T.; Schaardenburg, D. van; Caroline, C. & Prevost, T. (2023), Abatacept in Individuals at Risk of Developing Rheumatoid Arthritis: Results from the Arthritis Prevention in the Pre-clinical Phase of RA with Abatacept (APIPPRA) Trial, Arthritis & Rheumatology 75: 1672-1674.
- Volkov, M.; Kampstra, A.; Schie, K. van; Kwekkeboom, J.; Ru, A. de; Veelen, P. van; Huizinga, T.; Toes, R. & Woude, D. van der (2023), Acetylated Bacterial Proteins as Potent Antigens Inducing an Anti-modified Protein Antibody Response, Arthritis & Rheumatology 75: 4820-4822.
- Wesemael, T. van; Svärd, A.; Dorjee, A.; Huizinga, T.; Toes, R. & Woude, D. van der (2023), Smoking as a Risk Factor for Rheumatoid Arthritis: Exclusive Association with IgA Autoantibodies, Arthritis & Rheumatology 75: 3475-3477.
- Kissel, T.; Hafkenscheid, L.; Wesemael, T.J.; Tamai, M.; Kawashiri, S.Y.; Kawakami, A.; El-Gabalawy, H.S.; Schaardenburg, D.; Rantapaa-Dahlqvist, S.; Wuhrer, M.; Mil, A.H.M.V.V.; Allaart, C.F.; Woude, D.; Scherer, H.U.; Toes, R.E.M. & Huizinga, T.W.J. (2022), IgG Anti-Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ∼1,500 Samples, Arthritis & Rheumatology 74(7): 1147-1158.
- Liem, S.I.E.; Boonstra, M.; Cessie, S. le; Riccardi, A.; Airo, P.; Distler, O.; Matucci-Cerinic, M.; Caimmi, C.; Siegert, E.; Allanore, Y.; Huizinga, T.W.J.; Toes, R.E.M.; Scherer, H.U.; Vries-Bouwstra, J.K. de & EUSTAR Collaborators (2022), Sex-specific risk of anti-topoisomerase antibodies on mortality and disease severity in systemic sclerosis, The Lancet Rheumatology 4(10): E699-E709.
- Wesemael, T.J. van; Reijm, S.; Kawakami, A.; Maeda, T.; Kawashiri, S.Y.; Huizinga, T.; Tamai, M.; Toes, R. & Woude, D. van der (2022), ANTI-ACETYLATED PROTEIN IGM-ANTIBODIES AS THE STARTING POINT OF AUTOANTIBODY FORMATION IN RHEUMATOID ARTHRITIS?, Annals of the Rheumatic Diseases 81: 1168-1168.
- Scherer, H.U.; Woude, D. van der & Toes, R.E.M. (2022), From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis, Nature Reviews Rheumatology 18(7): 371-383.
- Wesemael, T.J. van; Huizinga, T.W.J.; Toes, R.E.M. & Woude, D. van der (2022), From phenotype to pathophysiology-placing rheumatic diseases in an immunological perspective, The Lancet Rheumatology 4(3): E166-E167.
- Reijm, S.; Brehler, A.S.; Rantapaa-Dahlqvist, S.; Kawakami, A.; Maeda, T.; Kawashiri, S.Y.; Tamai, M.; Woude, D. van der & Toes, R.E.M. (2022), Cross-reactivity of anti-modified protein antibodies is also present in predisease and individuals without rheumatoid arthritis, Annals of the Rheumatic Diseases 81(9): 1332-1334.
- Kissel, T.; Toes, R.E.M.; Huizinga, T.W.J. & Wuhrer, M. (2022), Glycobiology of rheumatic diseases, Nature Reviews Rheumatology 19.
- Schaik, M. van; Arends, E.J.; Soonawala, D.; Ommen, E. van; Leeuw, K. de; Limper, M.; Paassen, P. van; Huizinga, T.W.J.; Toes, R.E.M.; Kooten, C. van; Rotmans, J.I.; Rabelink, T.J. & Teng, Y.K.O. (2022), Efficacy of belimumab combined with rituximab in severe systemic lupus erythematosus: , Trials 23(1).
- Derksen, V.; Huizinga, T.; Toes, R. & Woude, D. van der (2022), AMPA CANNOT BE DETECTED IN FAECES OF SEROPOSITIVE RA PATIENTS: NO EVIDENCE FOR LOCAL AMPA PRODUCTION IN THE LOWER GASTRO-INTESTINAL TRACT, Annals of the Rheumatic Diseases 81: 1165-1165.
- Oskam, N.; Ooijevaar-de Heer, P.; Derksen, N.I.L.; Kruithof, S.; Taeye, S.W. de; Vidarsson, G.; Reijm, S.; Kissel, T.; Toes, R.E.M. & Rispens, T. (2022), At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity, The Journal of Immunology 209(1): 16-25.
- Wesemael, T.J. van; Beukel, M.D. van den; Hoogslag, A.T.W.; Huizinga, T.; Toes, R.; Trouw, L.A. & Woude, D. van der (2022), ANTIBODIES AGAINST ADVANCED GLYCATION END-PRODUCTS (ANTI-AGE) DISTINGUISH PATIENTS WITH A MORE INFLAMMATORY PROFILE AND WORSE OUTCOME IN SERONEGATIVE RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 81: 57-57.
- Merriman, T.; Matsuo, H.; Takei, R.; Leask, M.; Topless, R.; Shirai, Y.; Li, Z.Q.; Cadzow, M.; Reynolds, R.; Saag, K.; Fadason, T.; O'Sullivan, J.; Dalbeth, N.; Stamp, L.; Abhishek, A.; Doherty, M.; Roddy, E.; Jacobsson, L.; Kapetanovic, M.; Andres, M.; Perez-Ruiz, F.; Jimenez, R.T.; Radstake, T.; Jansen, T.; Janssen, M.; Joosten, L.; Crisan, T.O.; Huizinga, T.; Liote, F.; Richette, P.; Bardin, T.; Pascart, T.; McCarthy, G.; Stiburkova, B.; Tausche, A.; Uhlig, T.; Vitart, V.; Riches, P.; Ralston, S.; MacDonald, T.; Nakayama, A.; Nakatochi, M.; Ichida, K.; Takada, T.; Lee, C.; Brown, M.; Robinson, P.; Hill, C.; Choi, H.; Sumpter, N.; Merriman, M.; Phipps-Green, A.; Wei, W.H.; McCormick, S.; Melander, O.; Toes, R.; Ea, H.K.; Kurreeman, F.; Helbert, L.; Boutin, T.; Shinomiya, N.; Bradbury, L.; Buchanan, R.; Lester, S.; Smith, M.; Rischmueller, M.; Stahl, E.; Miner, J.; Solomon, D.; Cui, J.; Giacomini, K.; Brackman, D.; Jorgenson, E.; Shringapure, S.; So, A.; Okada, Y.; Li, C.G.; Shi, Y.Y.; Major, T.; Japan Gout Genomics Consortium J G; Japan Multiinstl Collab Cohort Stu & 23andme Res Team (2022), A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout, Arthritis & Rheumatology 74: 3338-3341.
- Kroos, S.; Kampstra, A.S.B.; Toes, R.E.M.; Slot, L.M. & Scherer, H.U. (2022), Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis, Arthritis Research and Therapy 24(1).
- Andreani, T.; Slot, L.M.; Gabillard, S.; Strubing, C.; Reimertz, C.; Yaligara, V.; Bakker, A.M.; Olfati-Saber, R.; Toes, R.E.M.; Scherer, H.U.; Auge, F. & Simaite, D. (2022), Benchmarking computational methods for B-cell receptor reconstruction from single-cell RNA-seq data, NAR Genomics and Bioinformatics 4(3).
- Sonigra, A.; Nel, H.J.; Wehr, P.; Ramnoruth, N.; Patel, S.; Schie, K.A. van; Bladen, M.W.; Mehdi, A.M.; Tesiram, J.; Talekar, M.; Rossjohn, J.; Reid, H.H.; Stuurman, F.E.; Roberts, H.; Vecchio, P.; Gourley, I.; Rigby, M.; Becart, S.; Toes, R.E.; Scherer, H.U.; Cao, K.A.L.; Campbell, K. & Thomas, R. (2022), Randomized phase I trial of antigen- specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA plus rheumatoid arthritis, JCI Insight 7(20).
- Kristyanto, H.; Holborough-Kerkvliet, M.D.; Lelieveldt, L.; Bartels, Y.; Hammink, R.; Schie, K.A.J. van; Toes, R.E.M.; Bonger, K.M. & Scherer, H.U. (2022), Multifunctional, Multivalent PIC Polymer Scaffolds for Targeting Antigen-Specific, Autoreactive B Cells, ACS Biomaterials Science & Engineering 8(4): 1486-1493.
- Derksen, V.F.A.M.; Allaart, C.F.; Helm-Van Mil, A.H.M. van der; Huizinga, T.W.J.; Toes, R.E.M. & Woude, D. van der (2022), In rheumatoid arthritis patients, total IgA1 and IgA2 levels are elevated, Rheumatology.
- Derksen, V.; Allaart, C.; Helm-Van Mil, A. van der; Huizinga, T.; Toes, R. & Woude, D. van der (2022), In rheumatoid arthritis patients, total IgA1 and IgA2 levels are elevated: implications for the mucosal origin hypothesis, Annals of the Rheumatic Diseases 81: 1170-1171.
- Wesemael, T.J. van; Verstappen, M.; Knevel, R.; Helm-Van Mil, A. van der; Huizinga, T.; Toes, R. & Woude, D. van der (2022), IN RHEUMATOID ARTHRITIS, THE ASSOCIATION BETWEEN ANTI-MODIFIED PROTEIN ANTIBODIES AND LONG-TERM OUTCOMES IS DOMINATED BY THE EFFECT OF ANTI-CITRULLINATED PROTEIN ANTIBODIES, Annals of the Rheumatic Diseases 81: 274-274.
- Blomberg, N.; Kristyanto, H.; Verstappen, M.; Neppelenbroek, S.; Kampstra, A.S.B.; Helm-van Mil, A. van der; Toes, R. & Scherer, H.U. (2022), DYNAMIC CHANGES IN AUTOREACTIVE MEMORY B CELLS IN RHEUMATOID ARTHRITIS: KEY TO UNDERSTANDING IMMUNOLOGICAL DISEASE ACTIVITY, Annals of the Rheumatic Diseases 81: 457-457.
- Wesemael, T.J. van; Verstappen, M.; Knevel, R.; Helm-van Mil, A.H.M. van der; Toes, R.E.M. & Woude, D. van der (2022), Anti-citrullinated protein antibodies dominate the association of long-term outcomes and anti-modified protein antibodies in rheumatoid arthritis.
- Bierling, T.; Gumann, A.; Schie, K. van; Wittner, J.; Wichert, M.; Hauke, M.; Toes, R.E.; Mielenz, D.; Jack, H.M. & Pracht, K. (2022), Glucose transporter type 1: metabolic player in antibody-secreting plasma cells, European Journal of Immunology 52: 94-94.
- Wortel, C.; Wetering, R. van de; Dooren, H. van; Stork, E.M.; Bakker, A.M.; Brehler, A.S.; Kissel, T.; Reijm, S.; Stoeken-Rijsbergen, G.; Schie, K. van; Rutgers, A.; Trouw, L.A.; Huizinga, T.; Teng, Y.K.O.; Kooten, C. van; Heeringa, P.; Toes, R. & Scherer, H.U. (2022), EXPANSION OF MYELOPEROXIDASE (MPO)-SPECIFIC IGM B CELLS IN ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS, Annals of the Rheumatic Diseases 81: 61-61.
- Brouwers, H.; Hegedus, J.H. von; Linden, E. van der; Mahdad, R.; Kloppenburg, M.; Toes, R.; Giera, M. & Ioan-Facsinay, A. (2022), Hyaluronidase treatment of synovial fluid is required for accurate detection of inflammatory cells and soluble mediators, Arthritis Research and Therapy 24(1).
- Volkov, M.; Coppola, M.; Huizinga, R.; Eftimov, F.; Huizinga, T.W.J.; Kooi, A.J. van der; Oosten, L.E.M.; Raaphorst, J.; Rispens, T.; Sciarrillo, R.; Titulaer, M.J.; Wieske, L.; Toes, R.E.M.; Huijbers, M.G.M.; Schie, K.A. van; Woude, D. van der & T2B Consortium (2022), Comprehensive overview of autoantibody isotype and subclass distribution, Journal of Allergy and Clinical Immunology 150(5): 999-1010.
- Kissel, T.; Ge, C.R.; Hafkenscheid, L.; Kwekkeboom, J.C.; Slot, L.M.; Cavallari, M.; He, Y.B.; Schie, K.A. van; Vergroesen, R.D.; Kampstra, A.S.B.; Reijm, S.; Stoeken-Rijsbergen, G.; Koeleman, C.; Voortman, L.M.; Heitman, L.H.; Xu, B.Z.; Pruijn, G.J.M.; Wuhrer, M.; Rispens, T.; Huizinga, T.W.J.; Scherer, H.U.; Reth, M.; Holmdahl, R. & Toes, R.E.M. (2022), Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation, Science Advances 8(6).
- Maurits, M.; Alcazar, L.A.; Akker, E. van den; Askling, J.; Barton, A.; Bluml, S.; Bohringer, S.; Cope, A.; Emery, P.; Eyre, S.; Gaddi, P.; Gonzalez, I.; Goodyear, C.; Helm-van Mil, A. van der; Hu, X.L.; Huizinga, T.; Isaacs, J.D.; Jelinsky, S.; Johannesson, M.; Zapata, S.J.; Ke, C.L.; Klareskog, L.; Lendrem, D.; Lewis, M.; Liu, M.D.; Martin, P.; McInnes, I.B.; Micheroli, R.; Morgan, A.; Morton, F.; Naamane, N.; Orozco, G.; Ospelt, C.; Padyukov, L.; Paterson, C.; Plant, D.; Porter, D.; Pratt, A.; Raychaudhuri, S.; Reynard, L.; Rodriguez-Rodriguez, L.; Sieghart, D.; Studenic, P.; Taylor, J.; Toes, R.; Verstappen, M.; Verstappen, S.; Westerlind, H.; Winkler, A. & Knevel, R. (2022), GWAS Identified New Genes in Synovial Fibroblasts Linked to Early Remission in RA, Arthritis and Rheumatology 74: 2265-2269.
- Gagestein, B.; Hegedus, J.H. von; Kwekkeboom, J.C.; Heijink, M.; Blomberg, N.; Wel, T. van der; Florea, B.I.; Elst, H.V.; Wals, K.; Overkleeft, H.S.; Giera, M.; Toes, R.E.M.; Ioan-Facsinay, A. & Stelt, M. van der (2022), Comparative photoaffinity profiling of omega-3 signaling lipid probes reveals prostaglandin reductase 1 as a metabolic hub in human macrophages, Journal of the American Chemical Society 144(41): 18938-18947.
- Derksen, V.; Allaart, C.F.; Helm-van Mil, A.H.M. van der; Huizinga, T.W.J.; Toes, R. & Woude, D. van der (2021), Elevated IgA Subclass Levels in Rheumatoid Arthritis Patients: Indications of a Mucosal Origin?, Arthritis and Rheumatology 73: 64-66.
- Wortel, C.; Leeuwen, N. van; Liem, S.; Boonstra, M.; Fehres, C.; Huizinga, T.; Toes, R.; Vries-Bouwstra, J. de & Scherer, H.U. (2021), PHENOTYPE AND FUNCTIONAL CHARACTERISTICS OF ANTIGEN-SPECIFIC, AUTO-REACTIVE B CELL RESPONSES REVEAL DIFFERENTIAL IMMUNOLOGICAL ACTIVITY IN PATIENTS WITH SYSTEMIC SCLEROSIS, Annals of the Rheumatic Diseases 80: 203-203.
- Volkov, M.; Kampstra, A.S.B.; Schie, K. van; Kwekkeboom, J.; Huizinga, T.; Toes, R. & Woude, D. van der (2021), A novel mechanism linking mucosal bacteria with autoantibody responses in RA: acetylated bacterial lysate as a model antigen, Annals of the Rheumatic Diseases 80: 422-422.
- Reijm, S.; Kissel, T.; Stoeken-Rijsbergen, G.; Slot, L.M.; Wortel, C.M.; Dooren, H.J. van; Levarht, N.E.W.; Kampstra, A.S.B.; Derksen, V.F.A.M.; Ooijevaar-de Heer, P.; Bang, H.; Drijfhout, J.W.; Trouw, L.A.; Huizinga, T.W.J.; Rispens, T.; Scherer, H.U. & Toes, R.E.M. (2021), Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load, Arthritis Research and Therapy 23(1).
- Volkov, M.; Kampstra, A.S.B.; Schie, K. van; Kawakami, A.; Tamai, M.; Kawashiri, S.Y.; Maeda, T.; Huizinga, T.; Toes, R. & Woude, D. van der (2021), Evolution of anti-modified protein antibody responses can be driven by consecutive exposure to different post-translational modifications, Annals of the Rheumatic Diseases 80: 423-423.
- Leeuwen, N.M. van; Boonstra, M.; Bakker, J.A.; Grummels, A.; Jordan, S.; Liem, S.; Distler, O.; Hoffmann-Vold, A.M.; Melsens, K.; Smith, V.; Truchetet, M.E.; Scherer, H.U.; Toes, R.; Huizinga, T.W.J. & Vries-Bouwstra, J.K. de (2021), Anticentromere antibody levels and isotypes and the development of systemic sclerosis, Arthritis and Rheumatology.
- Blomberg, N.; Kristyantol, H.; Huizinga, T.; Toes, R. & Scherer, H.U. (2021), Y autoreactive B cells in rheumatoid arthritis display an activated phenotype of recent antigen exposure, Annals of the Rheumatic Diseases 80(Suppl 1): 1045-1045.
- Wouters, F.; Maurits, M.; Boheemen, L. van; Verstappen, M.; Matthijssen, X.; Niemantsverdriet, E.; Knevel, R.; Schaardenburg, D. van; Toes, R. & Helm-van Mil, A. van der (2021), Determining in which preclinical stage HLA-shared epitope alleles and smoking exert their effect in the development of rheumatoid arthritis, Annals of the Rheumatic Diseases 80: 420-420.
- Wouters, F.; Maurits, M.P.; Boheemen, L. van; Verstappen, M.; Mankia, K.; Matthijssen, X.M.E.; Dorjee, A.L.; Emery, P.; Knevel, R.; Schaardenburg, D. van; Toes, R.E.M. & Helm-van Mil, A.H.M. van der (2021), Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis, Annals of the Rheumatic Diseases 81(1).
- Koppejan, H.; Hameetman, M.; Beyrend, G.; Unen, V. van; Kwekkeboom, J.C.; Helm-van Mil, A.H. van der; Toes, R.E.M. & Gaalen, F.A. van (2021), Immunoprofiling of early, untreated rheumatoid arthritis using mass cytometry reveals an activated basophil subset inversely linked to ACPA status, Arthritis Research and Therapy 23(1).
- Volkov, M.; Kampstra, A.S.B.; Schie, K.A.J. van; Huizinga, T.W.J.; Toes, R.E.M. & Woude, D. van der (2021), A novel mechanism linking mucosal bacteria with autoantibody response in RA: acetylated bacterial lysate as a model antigen, European Journal of Immunology 51: 256-256.
- Volkov, M.; Kampstra, A.; Schie, K. van; Kwekkeboom, J.; Huizinga, T.W.J.; Toes, R. & Woude, D. van der (2021), A Novel Mechanism Linking Mucosal Bacteria with Autoantibody-Responses in RA: Acetylated Bacterial Lysate as a Model Antigen, Arthritis and Rheumatology 73: 15-17.
- Volkov, M.; Schie, K.A.J. van; Bondt, A.; Kissel, T.; Brinkhaus, M.; Bentlage, A.; Koeleman, C.; Taeye, S. de; Dolhain, R.J.E.M.; Wuhrer, M.; Huizinga, T.W.J.; Toes, R.E.M.; Vidarsson, G. & Woude, D. van der (2021), Impact of IgG Fab-glycosylation on transplacental transfer of antibodies and their binding to the neonatal Fc-receptor (FcRn), European Journal of Immunology 51: 134-134.
- Volkov, M.; Schie, K. van; Bondt, A.; Kissel, T.; Brinkhaus, M.; Bentlage, A.; Koeleman, C.; Taeye, S. de; Dolhain, R.; Wuhrer, M.; Toes, R.; Vidarsson, G. & Woude, D. van der (2021), ACPA illustrating the impact of ICG fabglycosylation on transplacental transfer of antibodies and their binding to the neonatal FC-Receptor (FCRN), Annals of the Rheumatic Diseases 80(1): 1044-1044.
- Kissel, T.; Wesemael, T.J. van; Lundquist, A.; Kokkonen, H.; Kawakami, A.; Tamai, M.; Schaardenburg, D. van; Wuhrer, M.; Huizinga, T.W.J.; Scherer, H.U.; Woude, D. van der; Rantapaa-Dahlqvist, S. & Toes, R.E.M. (2021), Genetic predisposition (HLA-SE) is associated with ACPA-IgG variable domain glycosylation in the predisease phase of RA, Annals of the Rheumatic Diseases.
- Wesemael, T.J. van; Dorjee, A.L.; Huizinga, T.W.J.; Helm-van Mil, A.H.M. van der; Toes, R. & Woude, D. van der (2021), Lessons Learnt from Associations Between Anti-modified Protein -Antibodies and Risk Factors: Human Leukocyte Antigen -Shared Epitope Alleles Solely Associate with Anti-citrullinated Protein Antibodies, Arthritis and Rheumatology 73: 23-25.
- Wortel, C.; Leeuwen, N. van; Liem, S.; Boonstra, M.; Fehres, C.; Huizinga, T.; Toes, R.; Vries-Bouwstra, J. de & Scherer, H.U. (2021), Phenotype and functional characteristics of antigen-specific, auto-reactive B cell responses reveal differential immunological activity in patients with systemic sclerosis, Annals of the Rheumatic Diseases 80(Suppl 1): 203-203.
- Derksen, V.F.A.M.; Kissel, T.; Lamers-Karnebeek, F.B.G.; Bijl, A.E. van der; Venhuizen, A.C.; Huizinga, T.W.J.; Toes, R.E.M.; Roukens, A.H.E. & Woude, D. van der (2021), Onset of rheumatoid arthritis after COVID-19: coincidence or connected?
- Derksen, V.; Kissel, T.; Lamers-Karnebeek, F.; Bijl, A. van der; Venhuizen, C.; Huizinga, T.; Toes, R.; Roukens, A.H.E. & Woude, D. van der (2021), The onset of rheumatoid arthritis after Covid-19: coincedence or connected?, Annals of the Rheumatic Diseases 80(Suppl 1): 1366-1366.
- Westra, J.; Brouwer, E.; Raveling-Eelsing, E.; Arends, S.; Abdulle, A.E.; Roozendaal, C.; Delft, M.A.M. van; Toes, R.E.M.; Trouw, L.A.; Vissink, A. & Smit, M.J. de (2021), Arthritis autoantibodies in individuals without rheumatoid arthritis, Rheumatology 60(2): 658-666.
- Leeuwen, T. van; Araman, C.; Pournara, L.P.; Kampstra, A.S.B.; Bakkum, T.; Marqvorsen, M.H.S.; Nascimento, C.R.; Groenewold, G.J.M.; Wulp, W. van der; Camps, M.G.M.; Janssen, G.M.C.; Veelen, P.A. van; Westen, G.J.P. van; Janssen, A.P.A.; Florea, B.I.; Overkleeft, H.S.; Ossendorp, F.A.; Toes, R.E.M. & Kasteren, S.I. van (2021), Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens, RSC Chemical Biology 2(3): 855-862.
- Leeuwen, N.M. van; Wortel, C.M.; Fehres, C.M.; Bakker, J.A.; Scherer, H.U.; Toes, R.E.M.; Huizinga, T.W.J. & Vries-Bouwstra, J.K. de (2021), Association Between Centromere- and Topoisomerase-specific Immune Responses and the Degree of Microangiopathy in Systemic Sclerosis, The Journal of Rheumatology 48(3): 402-409.
- Fehres, C.M.; Koolmoes, B.; Levarth, N.W.N.; Sijben, H.J.; Heitman, L.H.; Postma, R.J.; Duinen, V. van; Zonneveld, A.J. van; Riemekasten, G.; Toes, R.E.M. & Bouwstra, J.K.D.V. (2021), Autoantibodies isolated from systemic sclerosis patients targeting the angiotensin II type 1 and endothelin-1 type A receptor induce endothelial cell activation and pro-fibrotic cellular responses, European Journal of Immunology 51: 50-50.
- Verheul, M.K.; Janssen, G.M.C.; Ru, A. de; Stoeken-Rijsbergen, G.; Levarht, E.W.N.; Kwekkeboom, J.C.; Bomer, N.; Ioan-Facsinay, A.; Meulenbelt, I.; Cordfunke, R.A.; Drijfhout, J.W.; Toes, R.E.M.; Veelen, P.A. van & Trouw, L.A. (2021), Mass-spectrometric identification of carbamylated proteins present in the joints of rheumatoid arthritis patients and controls, Clinical and Experimental Rheumatology 39(3): 570-577.
- Toes, R.E.M. & Raza, K. (2021), The autoimmune response as a potential target for tolerance induction before the development of rheumatoid arthritis, The Lancet Rheumatology 3(3): E214-E223.
- Slot, L.M.; Vergroesen, R.D.; Kerkman, P.F.; Staudinger, E.; Reijm, S.; Dooren, H.J. van; Voort, E.I.H. van der; Huizinga, T.W.J.; Toes, R.E.M. & Scherer, H.U. (2021), Light chain skewing in autoantibodies and B-cell receptors of the citrullinated antigen-binding B-cell response in rheumatoid arthritis, PLoS ONE 16(3).
- Wouters, F.; Niemantsverdriet, E.; Salioska, N.; Dorjee, A.L.; Toes, R.E.M. & Helm-van Mil, A.H.M. van der (2021), Do autoantibody-responses mature between presentation with arthralgia suspicious for progression to rheumatoid arthritis and development of clinically apparent inflammatory arthritis? A longitudinal serological study.
- Kawashiri, S.Y.; Endo, Y.; Nishino, A.; Shimizu, T.; Ueki, Y.; Eiraku, N.; Okada, A.; Matsuoka, N.; Yoshitama, T.; Nakamura, H.; Tamai, M.; Origuchi, T.; Toes, R.; Huizinga, T. & Kawakami, A. (2020), Association between the serologic status of isotype-specific autoantibodies and therapeutic efficacy in rheumatoid arthritis patients treated with abatacept: a prospective ultrasound cohort study in Japan, Annals of the Rheumatic Diseases 79: 624-624.
- Boonstra, M.; Bakker, J.A.; Grummels, A.; Ninaber, M.K.; Marsan, N.A.; Wortel, C.M.; Huizinga, T.W.J.; Jordan, S.; Hoffman-Vold, A.M.; Distler, O.; Toes, R.E.M.; Scherer, H.U. & Vries-Bouwstra, J.K. de (2020), Association of anti-topoisomerase I antibodies of the IgM isotype with disease progression in anti-topoisomerase I-positive systemic sclerosis, Arthritis and Rheumatology 72(11): 1897-1904.
- Kissel, T.; Reijm, S.; Slot, L.M.; Cavallari, M.; Wortel, C.M.; Vergroesen, R.D.; Stoeken-Rijsbergen, G.; Kwekkeboom, J.C.; Kampstra, A.S.B.; Levarht, E.W.N.; Drijfhout, J.W.; Bang, H.; Bonger, K.M.; Janssen, G.M.C.; Veelen, P.A. van; Huizinga, T.W.J.; Scherer, H.U.; Reth, M. & Toes, R.E.M. (2020), Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications, Annals of the Rheumatic Diseases 79(4): 472-480.
- Wortel, C.; Leeuwen, N. van; Boonstra, M.; Toes, R.; Huizinga, T.; Vries-Bouwstra, J. de & Scherer, H.U. (2020), Differential phenotypes of disease-specific auto-reactive B cell responses in patients with systemic sclerosis , Annals of the Rheumatic Diseases 79: 1089-1090.
- Hegedus, J.H. von; Kahnt, A.S.; Ebert, R.; Heijink, M.; Toes, R.E.M.; Giera, M. & Ioan-Facsinay, A. (2020), Toll-like receptor signaling induces a temporal switch towards a resolving lipid profile in monocyte-derived macrophages, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1865(9).
- Toes, R. & Pisetsky, D.S. (2020), Response to: "How to communicate in science" by Klareskog et al.
- Toes, R. & Pisetsky, D.S. (2020), Response to: 'Comment on editorial 'Pathogenic effector functions of ACPA: where do we stand'' by Holmdahl.
- Koning, M.T.; Vletter, E.M.; Rademaker, R.; Vergroesen, R.D.; Trollmann, I.J.M.; Parren, P.; Bergen, C.A.M. van; Scherer, H.U.; Kielbasa, S.M.; Toes, R.E.M. & Veelken, H. (2020), Templated insertions at VD and DJ junctions create unique B-cell receptors in the healthy B-cell repertoire, European Journal of Immunology 50(12).
- Kristyanto, H.; Blomberg, N.J.; Slot, L.M.; Voort, E.I.H. van der; Kerkman, P.F.; Bakker, A.; Burgers, L.E.; Brinck, R.M. ten; Helm-van Mil, A.H.M. van der; Spits, H.; Baeten, D.L.; Huizinga, T.W.J.; Toes, R.E.M. & Scherer, H.U. (2020), Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis, Science Translational Medicine 12(570).
- Fousert, E.; Toes, R. & Desai, J. (2020), Neutrophil extracellular traps (NETs) take the central stage in driving autoimmune responses, Cells 9(4).
- Moel, E.C. de; Derksen, V.; Trouw, L.A.; Terao, C.; Tikly, M.; El-Gabalawy, H.; Bang, H.; Huizinga, T.; Toes, R. & Woude, D. van der (2020), Geo-epidemiology of autoantibobies in Ra: different prevalences in four ethnically diverse Ra populations , Annals of the Rheumatic Diseases 79: 1247-1248.
- Reijm, S.; Kissel, T. & Toes, R.E.M. (2020), Checkpoints controlling the induction of B cell mediated autoimmunity in human autoimmune diseases, European Journal of Immunology 50(12).
- Wesemael, T. van; Salioska, N.; Dorjee, A.; Huizinga, T.; Helm-van Mil, A. van der; Toes, R. & Woude, D. van der (2020), Anti-acetylated Protein Antibodies in Rheumatoid Arthritis (RA): Clues for the Starting Point of Autoantibody Responses in RA, Arthritis and Rheumatology 72.
- Wouters, F.; Niemantsverdriet, E.; Salioska, N.; Dorjee, A.; Toes, R. & Helm-van Mil, A. van der (2020), Does the Autoantibody-Response Mature Between Presentation with Arthralgia and Development of Rheumatoid Arthritis? - a Longitudinal Serological Study, Arthritis and Rheumatology 72.
- Wouters, F.; Niemantsverdriet, E.; Salioska, N.; Dorjee, A.L.; Toes, R. & Helm-van Mil, A. van der (2020), Antibody-response maturation in the phase of clinically suspect arthralgia and its relation with progression to rheumatoid arthritis, Annals of the Rheumatic Diseases 79: 240-241.
- Lubbers, R.; Schaarenburg, R.A. van; Kwekkeboom, J.C.; Levarht, E.W.N.; Bakker, A.M.; Mahdad, R.; Monteagudo, S.; Cherifi, C.; Lories, R.J.; Toes, R.E.M.; Ioan-Facsinay, A. & Trouw, L.A. (2020), Complement component C1q is produced by isolated articular chondrocytes, Osteoarthritis and Cartilage 28(5): 675-684.
- Leeuwen, N. van; Bakker, J.; Grummels, A.; Wortel, C.; Jordan, S.; Liem, S.; Distler, O.; Hoffmann-Vold, A.M.; Melsens, K.; Smith, V.; Truchetet, M.E.; Scherer, H.U.; Toes, R.; Huizinga, T. & Vries-Bouwstra, J. de (2020), Anti-centromere antibody isotype levels as biomarker for disease progression in subjects at risk to develop systemic sclerosis, Annals of the Rheumatic Diseases 79: 1096-1096.
- Brouwers, H.; Jonasdottir, H.S.; Kuipers, M.E.; Kwekkeboom, J.C.; Auger, J.L.; Gonzalez-Torres, M.; Lopez-Vicario, C.; Claria, J.; Freysdottir, J.; Hardardottir, I.; Garrido-Mesa, J.; Norling, L.V.; Perretti, M.; Huizinga, T.W.J.; Kloppenburg, M.; Toes, R.E.M.; Binstadt, B.; Giera, M. & Ioan-Facsinay, A. (2020), Anti-inflammatory and proresolving effects of the omega-6 polyunsaturated fatty acid adrenic acid, Journal of Immunology 205(10): 2840-2849.
- Vletter, E.M.; Koning, M.T.; Scherer, H.U.; Veelken, H. & Toes, R.E.M. (2020), A comparison of immunoglobulin variable region N-linked glycosylation in healthy donors, autoimmune disease and lymphoma, Frontiers in Immunology 11.
- Kissel, T.; Ge, C.R.; Hafkenscheid, L.; Slot, L.; Cavallari, M.; Kwekkeboom, J.; Wuhrer, M.; Huizinga, T.; Scherer, H.; Reth, M.; Holmdahl, R. & Toes, R. (2020), N-linked Glycosylation of the Immunoglobulin Variable Domain Affects Antigen Binding and Autoreactive B Cell Activation, Arthritis and Rheumatology 72.
- Hafkenscheid, L.; Moel, E. de; Smolik, I.; Tanner, S.; Meng, X.B.; Jansen, B.C.; Bondt, A.; Wuhrer, M.; Huizinga, T.W.J.; Toes, R.E.M.; El-Gabalawy, H. & Scherer, H.U. (2019), N-Linked Glycans in the Variable Domain of IgG Anti-Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis, Arthritis and Rheumatology.
- Kissel, T.; Schie, K.A. van; Hafkenscheid, L.; Lundquist, A.; Kokkonen, H.; Wuhrer, M.; Huizinga, T.W.J.; Scherer, H.U.; Toes, R. & Rantapaa-Dahlqvist, S. (2019), On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis, Annals of the Rheumatic Diseases 78(12): 1616-1620.
- van Leeuwen N, Bakker J, Grummels A, Wortel C, Jordan S, Distler O, Fretheim H, Mann-Vold AMH, Scherer HU, Toes R, Huizinga T & de Vries-Bouwstra J (2019), Anticentromere Antibody Levels and Isotypes Associate with Disease Severity in Systemic Sclerosis, Arthritis and Rheumatology 71.
- Toes R, Lehman T, Bryson J, Kim AM, Balachandar S, Mukherjee S, Maldonado M, Connolly S & Huizinga T (2019), Change in Rheumatoid Arthritis (RA)-Related Autoantibody Profile and Risk of Disease Flare After Withdrawal of Therapy in Patients with Early RA Treated with Abatacept and MTX, Arthritis and Rheumatology 71.
- Moel, E.C. de; Rech, J.; Mahler, M.; Roth, J.; Vogl, T.; Schouffoer, A.; Goekoop, R.J.; Huizinga, T.W.J.; Allaart, C.F.; Toes, R.E.M.; Schett, G. & Woude, D. van der (2019), Circulating calprotectin (S100A8/A9) is higher in rheumatoid arthritis patients that relapse within 12 months of tapering anti-rheumatic drugs, Arthritis Research and Therapy 21(1).
- Huizinga T, Toes R, Weinblatt M, Schiff M, Fleischmann R, Elbez Y, Connolly S, Maldonado M & Gao S (2019), Effect of ACPA IgM Serostatus on Efficacy Outcomes Following Treatment with Abatacept or Adalimumab: A Post Hoc Analysis of a Phase III Head-to-Head Trial, Arthritis and Rheumatology 71.
- de Moel E, Teeuwisse W, Huizinga T, Toes R, Webb A & van der Woude D (2019), Increased Sodium Accumulation Detected by(23)Na-Magnetic Resonance Imaging in Inflamed Knees of Patients with Autoimmune Joint Disease, Arthritis and Rheumatology 71.
- de Moel E, Rech J, Mahler M, Roth J, Schouffoer A, Ronday K, Huizinga T, Allaart CF, Toes R, Schett G & van der Woude D (2019), Serum Calprotectin Is a Prognostic Marker for Drug-Free Remission in RA, Arthritis and Rheumatology 71.
- Vergroesen, R.D.; Slot, L.M.; Schaik, B.D.C. van; Koning, M.T.; Rispens, T.; Kampen, A.H.C. van; Toes, R.E.M. & Scherer, H.U. (2019), N-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell Development, Frontiers in Immunology 10.
- Kampstra, A.S.B.; Dekkers, J.S.; Volkov, M.; Dorjee, A.L.; Hafkenscheid, L.; Kempers, A.C.; Delft, M. van; Kissel, T.; Reijm, S.; Janssen, G.M.C.; Veelen, P.A. van; Bang, H.; Huizinga, T.W.J.; Trouw, L.A.; Woude, D. van der & Toes, R.E.M. (2019), Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification, Annals of the Rheumatic Diseases 78(7): 908-916.
- Germar, K.; Fehres, C.M.; Scherer, H.U.; Uden, N. van; Pollastro, S.; Yeremenko, N.; Hansson, M.; Kerkman, P.F.; Voort, E.I.H. van der; Reed, E.; Maassen, H.; Kwakkenbos, M.J.; Bakker, A.Q.; Klareskog, L.; Malmstrom, V.; Vries, N. de; Toes, R.E.M.; Lundberg, K.; Spits, H. & Baeten, D.L. (2019), Generation and Characterization of Anti-Citrullinated Protein Antibody-Producing B Cell Clones From Rheumatoid Arthritis Patients, Arthritis and Rheumatology 71(3): 340-350.
- Moel, E.C. de; Derksen, V.F.A.M.; Trouw, L.A.; Bang, H.; Collee, G.; Lard, L.R.; Ramiro, S.; Huizinga, T.W.J.; Allaart, C.F.; Toes, R.E.M. & Woude, D. van der (2019), In rheumatoid arthritis, changes in autoantibody levels reflect intensity of immunosuppression, not subsequent treatment response, Arthritis Research and Therapy 21.
- Boeters Debbie, Burgers Leonie, Toes Rene & van der Helm-van Mil Annette (2019), DOES IMMUNOLOGICAL REMISSION, DEFINED AS DISAPPEARANCE OF AUTOANTIBODIES, OCCUR WITH CURRENT TREATMENT STRATEGIES? A LONG-TERM FOLLOW-UP STUDY IN RHEUMATOID ARTHRITIS PATIENTS WHO ACHIEVED A SUSTAINED DMARD-FREE STATUS, Annals of the Rheumatic Diseases 78: 256-257.
- Toes, R. & Pisetsky, D.S. (2019), Pathogenic effector functions of ACPA: Where do we stand?, Annals of the Rheumatic Diseases 78(6): 716-721.
- Slot L. M., Vergroesen R. D., Schonkeren J. J. M., van Schaik B. D. C., van Kampen A. H. C., Rispens T., Kurreeman B. A. S., Toes R. E. M. & Scherer H. U. (2019), Molecular analysis of the anti-citrullinated protein B-cell response indicates aberrant selection processes during autoreactive B-cell development, European Journal of Immunology 49: 763-763.
- Wortel, C.M.; Leeuwen, N.M. van; Boonstra, M.; Bakker, J.A.; Toes, R.E.; Huizinga, T.W.; Vries-Bouwstra, J.K. de & Scherer, H.U. (2019), CHARACTERIZATION OF THE ANTI-CENTROMERE ANTIBODY RESPONSE IN SYSTEMIC SCLEROSIS PATIENTS SUGGESTS A BROAD AND ACTIVE B CELL RESPONSE, Annals of the Rheumatic Diseases 78: A22-A22.
- Kampstra, A.S.B.; Heemst, J. van; Janssen, G.M.; Ru, A.H. de; Lummel, M. van; Veelen, P.A. van & Toes, R.E.M. (2019), Ligandomes obtained from different HLA-class II-molecules are homologous for N- and C-terminal residues outside the peptide-binding cleft, Immunogenetics 71(8-9): 519-530.
- Ge, C.R.; Xu, B.Z.; Liang, B.B.; Lonnblom, E.; Lundstrom, S.L.; Zubarev, R.A.; Ayoglu, B.; Nilsson, P.; Skogh, T.; Kastbom, A.; Malmstrom, V.; Klareskog, L.; Toes, R.E.M.; Rispens, T.; Dobritzsch, D. & Holmdahl, R. (2019), Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies, Arthritis and Rheumatology 71(2): 210-221.
- van Leeuwen Nina, Bakker Jaap, Wortel Corrie, Scherer Hans Ulrich, Toes Rene, Huizinga Thomas & de Vries-Bouwstra Jeska (2019), ASSOCIATION BETWEEN CENTROMERE AND TOPOISOMERASE SPECIFIC IMMUNE RESPONSES AND THE DEGREE OF MICROANGIOPATHY IN SYSTEMIC SCLEROSIS, Annals of the Rheumatic Diseases 78: 1568-1568.
- Kissel Theresa, van Schie Karin, Hafkenscheid Lise, Lundquist Anders, Scherer Hans Ulrich, Kokkonen Heidi, Toes Rene & Dahlqvist Solbritt Rantapaa (2019), RISING ACPA IGG VARIABLE DOMAIN GLYCOSYLATION PRE-DISEASE ASSOCIATES WITH AN INCREASE IN AUTOANTIBODY LEVELS AND THE DEVELOPMENT OF RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 78: 249-250.
- Lubbers, R.; Schaarenburg, R.A. van; Kwekkeboom, J.C.; Levarht, E.W.N.; Bakker, A.M.; Mahdad, R.; Monteagudo, S.; Cherifi, C.; Lories, R.J.; Toes, R.E.M.; Ioan, A. & Trouw, L.A. (2019), Complement component C1q is produced by isolated articular chondrocytes, Osteoarthritis and Cartilage.
- Kissel, T.; Schie, K.A. van; Hafkenscheid, L.; Lundquist, A.; Kokkonen, H.; Wuhrer, M.; Huizinga, T.W.J.; Scherer, H.U.; Toes, R. & Rantapaa-Dahlqvist, S. (2019), On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis, Annals of the Rheumatic Diseases 78(12): 1616-1620.
- Koppejan, H.; Jansen, D.T.S.L.; Hameetman, M.; Thomas, R.; Toes, R.E.M. & Gaalen, F.A. van (2019), Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis, Arthritis Research and Therapy 21.
- Boeters, D.M.; Burgers, L.E.; Toes, R.E.M. & Helm-van Mil, A. van der (2019), Does immunological remission, defined as disappearance of autoantibodies, occur with current treatment strategies? A long-term follow-up study in rheumatoid arthritis patients who achieved sustained DMARD-free status, Annals of the Rheumatic Diseases 78(11): 1497-1504.
- Delft, M.A.M. van; Woude, D. van der; Toes, R.E.M. & Trouw, L.A. (2019), Secretory form of rheumatoid arthritis-associated autoantibodies in serum are mainly of the IgM isotype, suggesting a continuous reactivation of autoantibody responses at mucosal surfaces, Annals of the Rheumatic Diseases 78(1): 146-+.
- Moel, E.C. de; Rozeman, E.A.; Kapiteijn, E.H.; Verdegaal, E.M.E.; Grummels, A.; Bakker, J.A.; Huizinga, T.W.J.; Haanen, J.B.; Toes, R.E.M. & Woude, D. van der (2019), Autoantibody Development under Treatment with Immune-Checkpoint Inhibitors, Cancer Immunology Research 7(1): 6-11.
- Toes Rene (2019), POST-TRANSLATIONAL MODIFICATIONS OF ANTIBODIES: WHERE THERE'S SMOKE THERE'S FIRE, Annals of the Rheumatic Diseases 78: 53-53.
- Kristyanto Hendy, van der Voort Ellen, Kerkman Priscilla, Burgers Leonie, Ten Brinck Robin, van der Helm-van Mil Annette, Baeten Dominique, Huizinga Thomas, Toes Rene & Scherer Hans Ulrich (2019), THE IMMUNE-PATHOGENIC CHARACTERISTICS OF AUTOREACTIVE B CELLS AGAINST CITRULLINATED ANTIGENS IN RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 78: 1079-1079.
- Hafkenscheid Lise, de Moel Emma C., Smolik Irene, Meng Xiaobo, Tanner Stacy, Jansen Bas C., Bondt Albert, Wuhrer Manfred, Huizinga Thomas, Toes Rene, El-Gabalawy Hani & Scherer Hans Ulrich (2019), N-LINKED GLYCANS IN THE VARIABLE DOMAIN OF ACPA-IGG IN THE DEVELOPMENT OF RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 78: 228-229.
- Leeuwen, N. van; Boonstra, M.; Bakker, J.; Wortel, C.; Scherer, H.U.; Toes, R.; Huizinga, T. & Vries-Bouwstra, J. de (2019), AN ONGOING ANTICENTROMERE ANTIBODY RESPONSE ASSOCIATES WITH PROGRESSION TOWARDS SYSTEMIC SCLEROSIS, Annals of the Rheumatic Diseases 78: 2111-2111.
- Simaite Deimante, Slot Linda, Yaligara Veeranagouda, Savova Virginia, Reimertz Claus, Struebing Carsten, Dietrich Axel, de Rinaldis Emanuele, Didier Michel, Herrmann Matthias, Nestle Frank, Scherer Hans Ulrich & Toes Rene (2019), TRANSCRIPTOMIC CHARACTERIZATION OF SINGLE PATHOGENIC MEMORY B CELLS IN RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 78: 1475-1475.
- Jansen, D.T.S.L.; Emery, P.; Smolen, J.S.; Westhovens, R.; Bars, M. le; Connolly, S.E.; Ye, J.; Toes, R.E.M. & Huizinga, T.W.J. (2018), Conversion to seronegative status after abatacept treatment in patients with early and poor prognostic rheumatoid arthritis is associated with better radiographic outcomes and sustained remission: post hoc analysis of the AGREE study, RMD Open: Rheumatic and Musculoskeletal Diseases 4(1).
- Kempers, A.C.; Hafkenscheid, L.; Dorjee, A.L.; Moutousidou, E.; Bovenkamp, F.S. van de; Rispens, T.; Trouw, L.A.; Oosterhout, M. van; Huizinga, T.W.J.; Toes, R. & Scherer, H.U. (2018), The extensive glycosylation of the ACPA variable domain observed for ACPA-IgG is absent from ACPA-IgM.
- Moel, E.C. de; Derksen, V.F.A.M.; Stoeken, G.; Trouw, L.A.; Bang, H.; Goekoop, R.J.; Speyer, I.; Huizinga, T.W.J.; Allaart, C.F.; Toes, R.E.M. & Woude, D. van der (2018), Baseline autoantibody profile in rheumatoid arthritis is associated with early treatment response but not long-term outcomes, Arthritis Research and Therapy 20.
- Boonstra, M.; Bakker, J.A.; Grummels, A.; Ninaber, M.K.; Marsan, N.A.; Scherer, H.U.; Toes, R.E.; Huizinga, T.W. & Vries-Bouwstra, J.K. de (2018), CONTINUOUS PRESENCE OF IGM ANTI-TOPOISOMERASE I ANTIBODIES INDICATES AN ONGOING IMMUNE RESPONSE IN SYSTEMIC SCLEROSIS, Annals of the Rheumatic Diseases 77: 755-755.
- Boeters Debbie M., Burgers Leonie E., Toes Rene E. M. & van der Helm-van Mil Annette H. M. (2018), Disappearance of Autoantibodies in RA: Does It Occur with Current Treatment Strategies? a Long-Term Follow-up Study in Patients That Achieved DMARD-Free Sustained Remission, Arthritis and Rheumatology 70.
- Moel, E.C. de; Derksen, V.F.; Trouw, L.A.; Bang, H.; Goekoop-Ruiterman, Y.P.; Steup-Beekman, G.M.; Huizinga, T.W.; Allaart, C.F.; Toes, R.E. & Woude, D. van der (2018), IN RA, BECOMING SERONEGATIVE OVER THE 1ST YEAR OF DMARD TREATMENT DOES NOT TRANSLATE TO BETTER CHANCES OF DRUG-FREE REMISSION IN THE LONG-TERM, Annals of the Rheumatic Diseases 77: A16-A17.
- Jonasdottir, H.S.; Brouwers, H.; Toes, R.E.M.; Ioan-Facsinay, A. & Giera, M. (2018), Effects of anticoagulants and storage conditions on clinical oxylipid levels in human plasma, Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863(12): 1511-1522.
- Vergroesen R. D., Slot L. M., van de Bovenkamp F. S., Koning M. T., Huizinga T. W., Rispens T., Toes R. E. M. & Scherer H. U. (2018), MOLECULAR ANALYSIS OF ANTI-CITRULLINATED PROTEIN ANTIBODY VARIABLE REGIONS INDICATES ABERRANT SELECTION PROCESSES DURING ACPA B-CELL DEVELOPMENT, Annals of the Rheumatic Diseases 77: 203-203.
- Kraaij, T.; Kamerling, S.W.A.; Dam, L.S. van; Bakker, J.A.; Bajema, I.M.; Page, T.; Brunini, F.; Pusey, C.D.; Toes, R.E.M.; Scherer, H.U.; Rabelink, T.J.; Kooten, C. van & Teng, Y.K.O. (2018), Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA, Kidney International 94(1): 139-149.
- Rochelle D. Vergroesen, Linda M. Slot, Lise Hafkenscheid, Theresa Kissel, Fleur S. van de Bovenkamp, Marvyn T. Koning, Tom W.J. Huizinga, Theo Rispens, Hans U. Scherer & René E.M. Toes (2018), Introduction of N-glycosylation sites in B-cell receptors of anti-citrullinated protein antibody (ACPA-) expressing B cells indicate selective advantages in B-cell development.
- Rochelle D. Vergroesen, Linda M. Slot, Fleur S. van de Bovenkamp, Marvyn T. Koning, Theo Rispens, René E.M. Toes & Hans U. Scherer (2018), Aberrant selection processes during ACPA B-cell development.
- Verheul, M.K.; Bohringer, S.; Delft, M.A.M. van; Jones, J.D.; Rigby, W.F.C.; Gan, R.W.; Holers, V.M.; Edison, J.D.; Deane, K.D.; Janssen, K.M.J.; Westra, J.; Brink, M.; Rantapaa-Dahlqvist, S.; Huizinga, T.W.J.; Helm-van Mil, A.H.M. van der; Woude, D. van der; Toes, R.E.M. & Trouw, L.A. (2018), Triple Positivity for Anti-Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti-Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis: Implications for Very Early Identification of At-Risk Individuals, Arthritis and Rheumatology 70(11): 1721-1731.
- Volkov, M.; Dekkers, J.; Loos, B.G.; Bizzarro, S.; Huizinga, T.W.J.; Praetorius, H.A.; Toes, R.E.M. & Woude, D. van der (2018), Comment on "Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis", Science Translational Medicine 10(433).
- Delft, M.A.M. van; Verheul, M.K.; Burgers, L.E.; Rantapaa-Dahlqvist, S.; Helm-van Mil, A.H.M. van der; Huizinga, T.W.J.; Toes, R.E.M. & Trouw, L.A. (2018), The anti-carbamylated protein antibody response is of overall low avidity despite extensive isotype switching, Rheumatology 57(9): 1583-1591.
- Brouwers H., von Hegedus J. H., Toes R. E. M., Huizinga T. W. J., Giera M. A., Kloppenburg M. & Ioan-Facsinay A. (2018), THE IMPORTANCE OF PROPER HANDLING OF HUMAN SYNOVIAL FLUID FOR ARTHRITIS RESEARCH, Annals of the Rheumatic Diseases 77: 880-880.
- Kempers, A.C.; Hafkenscheid, L.; Dorjee, A.L.; Moutousidou, E.; Bovenkamp, F.S. van de; Rispens, T.; Trouw, L.A.; Oosterhout, M. van; Huizinga, T.W.J.; Toes, R. & Scherer, H.U. (2018), The extensive glycosylation of the ACPA variable domain observed for ACPA-IgG is absent from ACPA-IgM, Annals of the Rheumatic Diseases 77(7): 1087-+.
- Rivellese, F.; Mauro, D.; Nerviani, A.; Pagani, S.; Fossati-Jimack, L.; Messemaker, T.; Kurreeman, F.A.S.; Toes, R.E.M.; Ramming, A.; Rauber, S.; Schett, G.; Jones, G.W.; Jones, S.A.; Rossi, F.W.; Paulis, A. de; Marone, G.; Shikh, M.E.M. el; Humby, F. & Pitzalis, C. (2018), Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production, Annals of the Rheumatic Diseases 77(12): 1773-1781.
- Kraaij, T.; Kamerling, S.W.A.; Rooij, E.N.M. de; Daele, P.L.A. van; Bredewold, O.W.; Bakker, J.A.; Bajema, I.M.; Scherer, H.U.; Toes, R.E.M.; Huizinga, T.J.W.; Rabelink, T.J.; Kooten, C. van & Teng, Y.K.O. (2018), The NET-effect of combining rituximab with belimumab in severe systemic lupus erythematosus, Journal of Autoimmunity 91: 45-54.
- Verheul, M.K.; Veelen, P.A. van; Delft, M.A.M. van; Ru, A. de; Janssen, G.M.C.; Rispens, T.; Toes, R.E.M. & Trouw, L.A. (2018), Pitfalls in the detection of citrullination and carbamylation, Autoimmunity Reviews 17(2): 136-141.
- de Moel Emma, Rozeman Elisa, Kapiteijn Ellen, Verdegaal Els, Grummels Annette, Bakker Jaap A., Huizinga Tom W. J., Haanen John, Toes Rene E. M. & van der Woude Diane (2018), Treatment with Immune Checkpoint Inhibitors and the Development of Autoantibodies, Arthritis and Rheumatology 70.
- Bovenkamp, F.S. van de; Derksen, N.I.L.; Ooijevaar-de Heer, P.; Schie, K.A. van; Kruithof, S.; Berkowska, M.A.; Schoot, C.E. van der; IJspeert, H.; Burg, M. van der; Gils, A.; Hafkenscheid, L.; Toes, R.E.M.; Rombouts, Y.; Plomp, R.; Wuhrer, M.; Ham, S.M. van; Vidarsson, G. & Rispens, T. (2018), Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region, Proceedings of the National Academy of Sciences 115(8): 1901-1906.
- Falkenburg, W.J.J.; Kempers, A.C.; Dekkers, G.; Ooijevaar-de Heer, P.; Bentlage, A.E.H.; Vidarsson, G.; Schaardenburg, D. van; Toes, R.E.M.; Scherer, H.U. & Rispens, T. (2018), Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation (vol 56, pg 2025, 2017), Rheumatology 57(4): 771-771.
- de Moel E. G., Rozeman L., Grummels A., Verdegaal E. M. E., Bakker J. A., Kapiteijn E. H., Huizinga T. W. J., Haanen J. B., Toes R. E. M. & van der Woude D. (2018), TREATMENT WITH IMMUNE CHECKPOINT INHIBITORS AND THE BREAK OF B-CELL TOLERANCE TO AUTOANTIGENS, Annals of the Rheumatic Diseases 77: 240-240.
- Jong, A.J. de; Klein-Wieringa, I.R.; Kwekkeboom, J.C.; Toes, R.E.M.; Kloppenburg, M. & Ioan-Facsinay, A. (2018), Inflammatory features of infrapatellar fat pad in rheumatoid arthritis versus osteoarthritis reveal mostly qualitative differences, Annals of the Rheumatic Diseases 77(7): 1088-+.
- Kempers, A.C.; Nejadnik, M.R.; Rombouts, Y.; Ioan-Facsinay, A.; Oosterhout, M. van; Jiskoot, W.; Huizinga, T.W.J.; Toes, R.E.M. & Scherer, H.U. (2018), Fc gamma receptor binding profile of anti-citrullinated protein antibodies in immune complexes suggests a role for Fc gamma RI in the pathogenesis of synovial inflammation, Clinical and Experimental Rheumatology 36(2): 284-293.
- Moel, E.C. de; Derksen, V.F.; Trouw, L.A.; Bang, H.; Goekoop, R.J.; Speyer, I.; Huizinga, T.W.; Allaart, C.F.; Toes, R.E. & Woude, D. van der (2018), BASELINE AUTOANTIBODY PROFILE IN RHEUMATOID ARTHRITIS ASSOCIATES WITH EARLY TREATMENT RESPONSE BUT NOT LONG-TERM OUTCOMES, Annals of the Rheumatic Diseases 77: A25-A25.
- Knopf, J.; Magorivska, I.; Maier, J.M.; Spitzer, P.; Bilyy, R.; Biermann, M.H.C.; Hychka, K.; Bondt, A.; Wuhrer, M.; Toes, R.E.M.; Schett, G.; Herrmann, M. & Munoz, L.E. (2018), Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG, Journal of Neuroimmunology 320: 19-24.
- Slutter B., Depuydt M., van Duijn J., Bot I., Wezel A., Koppejan H., Toes R. & Kuiper J. (2018), MASSCYTOMETRY IDENTIFIES CD8 T-CELL DIVERSITY IN HUMAN ATHEROSCLEROTIC LESIONS, Atherosclerosis 275: E8-E8.
- Vergroesen, R.D.; Slot, L.M.; Hafkenscheid, L.; Koning, M.T.; Scherer, H.U. & Toes, R.E.M. (2018), Response to: 'Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases' by Visser et al, Annals of the Rheumatic Diseases 77(10).
- Lelieveldt, L.P.W.M.; Kristyanto, H.; Pruijn, G.J.M.; Scherer, H.U.; Toes, R.E.M. & Bonger, K.M. (2018), Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells, Molecular Pharmaceutics 15(12): 5565-5573.
- Jong, A.J. de; Pollastro, S.; Kwekkeboom, J.C.; Andersen, S.N.; Dorjee, A.L.; Bakker, A.M.; Alzaid, F.; Soprani, A.; Nelissen, R.G.H.H.; Mullers, J.B.; Venteclef, N.; Vries, N. de; Kloppenburg, M.; Toes, R.E.M. & Ioan-Facsinay, A. (2018), Functional and phenotypical analysis of IL-6-secreting CD4(+) Tcells in human adipose tissue, European Journal of Immunology 48(3): 471-481.
- Kempers, A.C.; Hafkenscheid, L.; Scherer, H.U. & Toes, R.E.M. (2018), Variable domain glycosylation of ACPA-IgG: A missing link in the maturation of the ACPA response?, Clinical Immunology 186: 34-37.
- Baecklund, E.; Backlin, C.; Ronnelid, J.; Toes, R.; Huizinga, T.W.J.; Ahlin, E.; Askling, J.; Hochberg, F.H.; Klareskog, L.; Kay, J. & Smedby, K.E. (2018), Anti-cyclic citrullinated peptide antibodies, other common autoantibodies, and smoking as risk factors for lymphoma in patients with rheumatoid arthritis, Scandinavian Journal of Rheumatology 47(4): 270-275.
- Moel, E. de; Derksen, V.; Trouw, L.A.; Bang, H.; Collee, G.; Lard, L.R.; Huizinga, T.W.J.; Allaart, C.E.; Toes, R.E.M. & Woude, D. van der (2018), In Rheumatoid Arthritis, Changes in Autoantibody Levels Do Not Associate with Treatment Response, but Are a Reflection of Treatment Intensity, Arthritis and Rheumatology 70.
- Molhoek A., Hafkenscheid L., Toes R., van Vliet S. & van Kooyk Y. (2018), HOW DO GLYCANS AFFECT IMMUNE CELLS IN RHEUMATOID ARTHRITIS?, Annals of the Rheumatic Diseases 77: A14-A15.
- Vergroesen, R.D.; Slot, L.M.; Hafkenscheid, L.; Koning, M.T.; Voort, E.I.H. van der; Grooff, C.A.; Zervakis, G.; Veelken, H.; Huizinga, T.W.J.; Rispens, T.; Scherer, H.U. & Toes, R.E.M. (2018), B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutation, Annals of the Rheumatic Diseases 77(6): 955-+.
- Brinck, R.M. ten; Toes, R.E.M. & Helm-van Mil, A.H.M. van der (2018), Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia, Arthritis Research and Therapy 20.
- Moel, E.C. de; Derksen, V.F.A.M.; Trouw, L.A.; Bang, H.; Goekoop-Ruiterman, Y.P.M.; Steup-Beekman, G.M.; Huizinga, T.W.J.; Allaart, C.F.; Toes, R.E.M. & Woude, D. van der (2018), In RA, becoming seronegative over the first year of treatment does not translate to better chances of drug-free remission, Annals of the Rheumatic Diseases 77(12): 1836-+.
- Moel, E.C. de; Derksen, V.F.A.M.; Trouw, L.A.; Bang, H.; Goekoop-Ruiterman, Y.P.; Steup-Beekman, G.M.; Huizinga, T.W.J.; Allaart, C.F.; Toes, R.E.M. & Woude, D. van der (2018), IN RA, BECOMING SERONEGATIVE OVER THE 1ST YEAR OF DMARD TREATMENT DOES NOT TRANSLATE TO BETTER CHANCES OF SUSTAINED DRUG-FREE REMISSION IN THE LONG-TERM, Annals of the Rheumatic Diseases 77: 258-259.
- Messemaker, T.C.; Chadli, L.; Cai, G.S.; Goelela, V.S.; Boonstra, M.; Dorjee, A.L.; Andersen, S.N.; Mikkers, H.M.M.; Van't Hof, P.; Mei, H.L.; Distler, O.; Draisma, H.H.M.; Johnson, M.E.; Orzechowski, N.M.; Simms, R.W.; Toes, R.E.M.; Aarbiou, J.; Huizinga, T.W.; Whitfield, M.L.; DeGroot, J.; Vries-Bouwstra, J. de & Kurreeman, F. (2018), Antisense Long Non-Coding RNAs Are Deregulated in Skin Tissue of Patients with Systemic Sclerosis, Journal of Investigative Dermatology 138(4): 826-835.
- Manivel, V.A.; Woude, D. van der; Toes, R.; Filer, A.; Raza, K. & Ronnelid, J. (2018), Antibodies against collagen type II are not a general marker of acute arthritis onset, Annals of the Rheumatic Diseases 77(6): 954-+.
- Scherer, H.U.; Huizinga, T.W.J.; Kronke, G.; Schett, G. & Toes, R.E.M. (2018), The B cell response to citrullinated antigens in the development of rheumatoid arthritis, Nature Reviews Rheumatology 14(3): 157-169.
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- Falkenburg, W.J.J.; Kempers, A.C.; Dekkers, G.; Heer, P.O.D.; Bentlage, A.E.H.; Vidarsson, G.; Schaardenburg, D. van; Toes, R.E.M.; Scherer, H.U. & Rispens, T. (2017), Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation, Rheumatology 56(11): 2025-2030.
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- Molhoek, A.K.; Lubbers, J.; Garcia-Vellejo, J.J.; Vliet, S.J. van; Toes, R.E.M. & Kooyk, Y. van (2017), HOW DO GLYCANS AFFECT IMMUNE CELLS IN RA?, Annals of the Rheumatic Diseases 76: A76-A77.
- Dekkers, J.S.; Schoones, J.W.; Huizinga, T.W.; Toes, R.E. & Helm-van Mil, A.H. van der (2017), Possibilities for preventive treatment in rheumatoid arthritis? Lessons from experimental animal models of arthritis: a systematic literature review and meta-analysis, Annals of the Rheumatic Diseases 76(2): 458-467.
- Hegedus, J.H. von; Madari, Q.S.R.; Muller, P.C.E.H.; Kloppenburg, M.; Toes, R.E.M.; Giera, M.; Huizinga, T.W.J.; Cate, R. ten & Ioan-Facsinay, A. (2017), Characterisation of Lipid Mediator Profile and Immune Cells in Synovial Fluid of Juvenile Idiopathic Arthritis, Arthritis and Rheumatology 69.
- Ajeganova, S.; Steenbergen, H.W. van; Verheul, M.K.; Forslind, K.; Hafstrom, I.; Toes, R.E.M.; Huizinga, T.W.J.; Svensson, B.; Trouw, L.A. & Helm-van Mil, A.H.M. van der (2017), The association between anti-carbamylated protein (anti-CarP) antibodies and radiographic progression in early rheumatoid arthritis: a study exploring replication and the added value to ACPA and rheumatoid factor, Annals of the Rheumatic Diseases 76(1): 112-118.
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- Messemaker, T.; Chadli, L.; Cal, G.; Goelela, V.; Boonstra, M.; Dorjee, A.; Andersen, S.; Mikkers, H.; Huizinga, T.; Li, Z.; Distler, O.; Whitfield, M.; Toes, R.; Aarbiou, J.; Groot, J. de; Vries-Bouwstra, J. de & Kurreeman, F. (2017), ANTISENSE LONG NONCODING RNAS ARE DEREGULATED IN SKIN TISSUE OF SSC PATIENTS, Annals of the Rheumatic Diseases 76: 621-621.
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- Koning, M.T.; Bergen, C.A.M. van; Trollmann, I.J.M.; Scherer, H.U.; Attikum, H. van; Toes, R.E.M.; Kielbasa, S.M.; Tijsterman, M. & Veelken, H. (2016), Prevalence, structure and putative mechanism for large genetic insertions in VDJ recombination, European Journal of Immunology 46: 1136-1136.
- Heemst, J. van; Hensvold, A.H.; Jiang, X.; Steenbergen, H. van; Klareskog, L.; Huizinga, T.W.J.; Helm-van Mil, A. van der; Catrina, A.I.; Toes, R.E.M.; Lundberg, K. & Woude, D. van der (2016), Protective effect of HLA-DRB1*13 alleles during specific phases in the development of ACPA-positive RA, Annals of the Rheumatic Diseases 75(10): 1891-1898.
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- Krabben, A.; Wilson, A.G.; Rooy, D.P.C. de; Zhernakova, A.; Brouwer, E.; Lindqvist, E.; Saxne, T.; Stoeken, G.; Nies, J.A.B. van; Knevel, R.; Huizinga, T.W.J.; Toes, R.; Gregersen, P.K. & Helm-van Mil, A.H.M. van der (2013), Association of Genetic Variants in the IL4 and IL4R Genes With the Severity of Joint Damage in Rheumatoid Arthritis: A Study in Seven Cohorts, Arthritis and Rheumatism 65(12): 3051-3057.
- Liu, B.; Stoop, J.N.; Huizinga, T.W. & Toes, R. (2013), IL-21 synergistically enhances TLR-MyD88-STAT3 pathway but not the conventional TLR-MyD88-NF-kappa B pathway in human B cells, resulted in increased antibody production, Immunology 140: 63-63.
- Scally, S.W.; Petersen, J.; Law, S.C.; Dudek, N.L.; Nel, H.J.; Loh, K.L.; Wijeyewickrema, L.C.; Eckle, S.B.G.; Heemst, J. van; Pike, R.N.; McCluskey, J.; Toes, R.E.; Gruta, N.L. la; Purcell, A.W.; Reid, H.H.; Thomas, R. & Rossjohn, J. (2013), A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis, Journal of Experimental Medicine 210(12): 2569-2582.
- Beers, J.J.B.C. van; Willemze, A.; Jansen, J.J.; Engbers, G.H.M.; Salden, M.; Raats, J.; Drijfhout, J.W.; Helm-van Mil, A.H.V. van der; Toes, R.E.M. & Pruijn, G.J.M. (2013), ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression.
- Shi, J.; Stadt, L.A. van de; Levarht, E.W.N.; Huizinga, T.W.J.; Toes, R.E.M.; Trouw, L.A. & Schaardenburg, D. van (2013), ANTI CARBAMYLATED PROTEIN ANTIBODIES (ANTI-CARP) ARE PRESENT IN ARTHRALGIA PATIENTS AND PREDICT THE DEVELOPMENT OF RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 72: A31-A31.
- Liu, B.; Huizinga, T. & Toes, R. (2013), TLR7/8 agonists and type I IFN induce the differentiation of human IL-10-producing B cells into antibody-producing B cells via the TLR-MyD88-STAT(3) pathway, Immunology 140: 61-61.
- Suurmond, J.; Heemst, J. van; Heiningen, J. van; Dorjee, A.L.; Schilham, M.W.; Beek, F.B. van der; Huizinga, T.W.J.; Schuerwegh, A.J.M. & Toes, R.E.M. (2013), Communication between human mast cells and CD4(+) T cells through antigen-dependent interactions, European Journal of Immunology 43(7): 1758-1768.
- Shi, J.; Willemze, A.; Janssen, G.M.C.; Veelen, P.A. van; Drijfhout, J.W.; Cerami, A.; Huizinga, T.W.J.; Trouw, L.A. & Toes, R.E. (2013), Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the 'AMC-Senshu' method, Annals of the Rheumatic Diseases 72(1): 148-150.
- Rica, L. de la; Urquiza, J.M.; Gomez-Cabrero, D.; Islam, A.B.M.M.K.; Lopez-Bigas, N.; Tegner, J.; Toes, R.E.M. & Ballestar, E. (2013), Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression, Journal of Autoimmunity 41: 6-16.
- Rooy, D. de; Tsonaka, R.; Andersson, M.; Forslind, K.; Zhernakova, A.; Kovel, C. de; Koeleman, B.; Heijde, D. van der; Huizinga, T.; Toes, R.; Houwing-Duistermaat, J.; Svensson, B. & Helm-van Mil, A. van der (2013), GENETIC FACTORS FOR THE SEVERITY OF ACPA-NEGATIVE RHEUMATOID ARTHRITIS IN TWO COHORTS OF EARLY DISEASE: A GENOME-WIDE STUDY, Annals of the Rheumatic Diseases 72: 55-55.
- Scherer, H.U.; Rombouts, Y.; Ewing, E.; Stadt, L.A. van de; Selman, M.H.; Deelder, A.M.; Huizinga, T.W.; Wuhrer, M.; Schaardenburg, D. van & Toes, R.E. (2013), ANTI-CITRULLINATED PROTEIN ANTIBODY SPECIFIC FC GLYCOSYLATION PATTERNS IN PATIENTS WITH ARTHRALGIA, Annals of the Rheumatic Diseases 72: 116-117.
- Muhammad, A.; Wesemael, T. van; Kochi, Y.; Mjaavatten, M.; Wevers-de Boer, K.; Allaart, C.; Trouw, L.; Suzuki, A.; Yamamoto, K.; Huizinga, T.; Toes, R. & Woude, D. van der (2013), SMOKING IS NOT PRIMARILY ASSOCIATED WITH ACPA, BUT WITH THE PRESENCE OF MULTIPLE AUTOANTIBODIES IN RA, Annals of the Rheumatic Diseases 72: 117-117.
- Klein-Wieringa, I.; Andersen, S.; Herb-van Toorn, L.; Kwekkeboom, J.; Helm-van Mil, A.; Meulenbelt, I.; Huizinga, T.; Kloppenburg, M.; Toes, R. & Loan-Facsinay, A. (2013), DO HIGH MOLECULAR WEIGHT ADIPONECTIN LEVELS ASSOCIATE WITH RADIOGRAPHIC PROGRESSION IN RHEUMATOID ARTHRITIS AND HAND OSTEOARTHRITIS?, Annals of the Rheumatic Diseases 72: 202-203.
- Klein-Wieringa, I.R.; Andersen, S.N.; Kwekkeboom, J.C.; Giera, M.; Lange-Brokaar, B.J.E. de; Osch, G.J.V.M. van; Zuurmond, A.M.; Stojanovic-Susulic, V.; Nelissen, R.G.H.H.; Huizinga, T.W.J.; Kloppenburg, M.; Toes, R.E.M. & Ioan-Facsinay, A. (2013), Adipocytes Modulate the Phenotype of Macrophages Through Secreted Lipids, Annals of the Rheumatic Diseases 72: A24-A24.
- Bossini-Castillo, L.; Kovel, C. de; Kallberg, H.; Coenen, M.J.H.; Tak, P.P.; Posthumus, M.D.; Wijmenga, C.; Huizinga, T.W.J.; Helm-van Mil,AHM van der; Rodriguez-Rodriguez, L.; Gonzalez-Alvaro, I.; Gonzalez-Gay, M.A.; Horst-Bruinsma, I.E. van der; Dijkmans, B.A.C.; Wolbink, G.J.; Ophoff, R.A.; Riel, P.L.C.M. van; Klareskog, L.; Crusius, J.B.A.; Brouwer, E.; Martin, J.; Vries, N. de; Toes, R.E.M.; Padyukov, L. & Koeleman, B.P.C. (2013), A Genome Wide Association Study Of Rheumatoid Arthritis Without Antibodies Against Citrullinated Peptides, Arthritis and Rheumatism 65: S343-S343.
- Suurmond, J.; Stoop, J.N.; Bakker, A.M.; Huizinga, T.W.J.; Toes, R.E.M. & Schuerwegh, A.J.M. (2013), Toll-Like Receptor Triggering of Human Basophils May Synergise with IgE-Mediated Activation in ACPA plus RA, Annals of the Rheumatic Diseases 72: A79-A79.
- Kerkman, P.F.; Rombouts, Y.; Voort, E.I.H. van der; Trouw, L.A.; Huizinga, T.W.J.; Toes, R.E.M. & Scherer, H.U. (2013), SPONTANEOUS PRODUCTION OF ANTI-CITRULLINATED PROTEIN ANTIBODIES IN CULTURES OF PERIPHERAL BLOOD MONONUCLEAR CELLS AND SYNOVIAL FLUID MONONUCLEAR CELLS ISOLATED FROM PATIENTS WITH RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 72: A41-A41.
- Woude, D. van der; Scherer, H.U.; Huizinga, T.W.J. & Toes, R.E.M. (2013), Pathogenic relevance of anti-citrullinated vimentin antibodies: comment on the article by Montes et al, Arthritis and Rheumatism 65(2): 541-542.
- Rooy, D.P.C. de; Zhernakova, A.; Tsonaka, R.; Willemze, A.; Kurreeman, B.A.S.; Toes, R.E.M.; Huizinga, T.W.J.; Houwing-Duistermaat, J.J.; Gregersen, P.K. & Helm-van Mil, A.H.M. van der (2013), A GENETIC VARIANT IN THE REGION OF MMP-9 IS ASSOCIATED WITH SERUM LEVELS AND PROGRESSION OF JOINT DAMAGE IN RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 72: A48-A48.
- Klein-Wieringa, I.R.; Andersen, S.N.; Kwekkeboom, J.C.; Herb-van Toorn, L.; Helm-van Mil, A. van der; Meulenbelt, I.; Huizinga, T.J.; Kloppenburg, M.; Toes, R.E. & Ioan-Facsinay, A. (2013), DO HIGH MOLECULAR WEIGHT ADIPONECTIN LEVELS ASSOCIATE WITH RADIOGRAPHIC PROGRESSION IN EARLY RHEUMATIOD ARTHRITIS AND HAND OSTEOARTHRITIS?, Osteoarthritis and Cartilage 21: S136-S136.
- Klein-Wieringa, I.R.; Andersen, S.N.; Kwekkeboom, J.C.; Herb-van Toorn, L.; Helm-van Mil, A.H.M. van der; Meulenbelt, I.; Huizinga, T.W.J.; Kloppenburg, M.; Toes, R.E.M. & Ioan-Facsinay, A. (2013), DO HIGH MOLECULAR WEIGHT ADIPONECTIN LEVELS ASSOCIATE WITH RADIOGRAPHIC PROGRESSION IN EARLY RHEUMATOID ARTHRITIS AND HAND OSTEOARTHRITIS?, Annals of the Rheumatic Diseases 72: A25-A25.
- Cui, J.; Stahl, E.A.; Saevarsdottir, S.; Miceli, C.; Diogo, D.; Trynka, G.; Raj, T.; Mirkov, M.U.; Canhao, H.; Ikari, K.; Terao, C.; Okada, Y.; Wedren, S.; Askling, J.; Yamanaka, H.; Momohara, S.; Taniguchi, A.; Ohmura, K.; Matsuda, F.; Mimori, T.; Gupta, N.; Kuchroo, M.; Morgan, A.W.; Isaacs, J.D.; Wilson, A.G.; Hyrich, K.L.; Herenius, M.; Doorenspleet, M.E.; Tak, P.P.; Crusius, J.B.A.; Horst-Bruinsma, I.E. van der; Wolbink, G.J.; Riel, P.L.C.M. van; Laar, M. van de; Guchelaar, H.J.; Shadick, N.A.; Allaart, C.F.; Huizinga, T.W.J.; Toes, R.E.M.; Kimberly, R.P.; Bridges, S.L.; Criswell, L.A.; Moreland, L.W.; Fonseca, J.E.; Vries, N. de; Stranger, B.E.; Jager, P.L. de; Raychaudhuri, S.; Weinblatt, M.E.; Gregersen, P.K.; Mariette, X.; Barton, A.; Padyukov, L.; Coenen, M.J.H.; Karlson, E.W. & Plenge, R.M. (2013), Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis, PLoS Genetics 9(3).
- Bannoudi, H. el; Han, W.G.H.; Stoop, J.N.; Louis-Plence, P.; Huizinga, T.W.J. & Toes, R.E.M. (2013), DX5+CD4+T cells modulate CD4+T-cell response via inhibition of IL-12 production by DCs, European Journal of Immunology 43(2): 439-446.
- Shi, J.; Stadt, L.A. van de; Levarht, E.W.N.; Huizinga, T.W.J.; Toes, R.E.M.; Trouw, L.A. & Schaardenburg, D. van (2013), Brief Report: AntiCarbamylated Protein Antibodies Are Present in Arthralgia Patients and Predict the Development of Rheumatoid Arthritis, Arthritis and Rheumatism 65(4): 911-915.
- Trouw, L.A.; Huizinga, T.W.J. & Toes, R.E.M. (2013), Autoimmunity in rheumatoid arthritis: different antigens-common principles, Annals of the Rheumatic Diseases 72: 132-136.
- Knevel, R.; Krabben, A.; Wilson, A.G.; Brouwer, E.; Leijsma, M.K.; Lindqvist, E.; Rooy, D.P.C. de; Daha, N.A.; Linden, M.P.M. van der; Tsonaka, S.; Zhernakova, A.; Westra, H.J.; Franke, L.; Houwing-Duistermaat, J.J.; Toes, R.E.M.; Huizinga, T.W.J.; Saxne, T. & Helm-van Mil, A.H.M. van der (2013), A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis, Arthritis and Rheumatism 65(3): 582-589.
- Ioan-Facsinay, A.; Kwekkeboom, J.C.; Westhoff, S.; Giera, M.; Rombouts, Y.; Huizinga, T.W.J.; Deelder, A.; Kloppenburg, M. & Toes, R.E.M. (2013), ADIPOCYTES MODULATE T CELL FUNCTION THROUGH RELEASE OF LIPIDS, Annals of the Rheumatic Diseases 72: A24-A24.
- Ewing, M.M.; Karper, J.C.; Abdul, S.; Jong, R.C.M. de; Peters, H.A.B.; Vries, M.R. de; Redeker, A.; Kuiper, J.; Toes, R.E.M.; Arens, R.; Jukema, J.W. & Quax, P.H.A. (2013), T-cell co-stimulation by CD28-CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development, International Journal of Cardiology 168(3): 1965-1974.
- Krabben, A.; Wilson, A.G.; Rooy, D.P.C. de; Zhernakova, A.; Brouwer, E.; Lindqvist, E.; Saxne, T.; Stoeken, G.; Nies, J.A.B. van; Knevel, R.; Huizinga, T.W.J.; Koeleman, B.; Toes, R.; Gregersen, P.K. & Helm-van Mil, A.H.M. van der (2013), Genetic Variants in the IL-4 and IL-4 Receptor Genes in Association with the Severity of Joint Damage in Rheumatoid Arthritis: A Study in Seven Cohorts, Annals of the Rheumatic Diseases 72: A51-A51.
- Rooy, D.P.C. de; Yeremenko, N.G.; Wilson, A.G.; Knevel, R.; Lindqvist, E.; Saxne, T.; Krabben, A.; Leijsma, M.K.; Daha, N.A.; Tsonaka, S.; Zhernakova, A.; Houwing-Duistermaat, J.J.; Huizinga, T.W.J.; Toes, R.E.M.; Baeten, D.L.P.; Brouwer, E. & Helm-van Mil, A.H.M. van der (2013), Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis, Annals of the Rheumatic Diseases 72(5): 769-775.
- Morree, A. de; Flix, B.; Bagaric, I.; Wang, J.; Boogaard, M. van den; Moursel, L.G.; Frants, R.R.; Illa, I.; Gallardo, E.; Toes, R. & Maarel, S.M. van der (2013), Dysferlin Regulates Cell Adhesion in Human Monocytes, Journal of Biological Chemistry 288(20): 14147-14157.
- Vries, M.R. de; Seghers, L.; Bergen, J. van; Peters, H.A.B.; Jong, R.C.M. de; Hamming, J.F.; Toes, R.E.M.; Hinsbergh, V.W.M. van & Quax, P.H.A. (2013), C57BL/6 NK cell gene complex is crucially involved in vascular remodeling, Journal of Molecular and Cellular Cardiology 64: 51-58.
- Humphreys, J.H.; Verstappen, S.M.; Hyrich, K.L.; Marshall, T.; Barton, A.; Toes, R.E.M.; Trouw, L.A. & Symmons, D.P. (2013), Anti-Carbamylated Antibody Positivity Is Associated With More Severe Radiological Progression In Patients With Recent Onset ACPA Negative Rheumatoid Arthritis: Results From The Norfolk Arthritis Register (NOAR), Arthritis and Rheumatism 65: S551-S551.
- Jonasdottir, H.S.; Nicolardi, S.; Jonker, W.; Derks, R.; Palmblad, M.; Ioan-Facsinay, A.; Toes, R.; Burgt, Y.E.M. van der; Deelder, A.M.; Mayboroda, O.A. & Giera, M. (2013), Detection and Structural Elucidation of Esterified Oxylipids in Human Synovial Fluid by Electrospray Ionization-Fourier Transform Ion-Cyclotron Mass Spectrometry and Liquid Chromatography-Ion Trap-MS3: Detection of Esterified Hydroxylated Docosapentaenoic Acid Containing Phospholipids, Analytical Chemistry 85(12): 6003-6010.
- Kempers, A.C.; Scherer, H.U.; Rombouts, Y.; Ewing, E.; Stadt, L.A. van de; Selman, M.H.J.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M.; Schaardenburg, D. van & Toes, R.E.M. (2013), ANTI-CITRULLINATED PROTEIN ANTIBODY SPECIFIC FC GLYCOSYLATION PATTERNS IN ARTHRALGIA PATIENTS, Annals of the Rheumatic Diseases 72: A1-A1.
- Willemze, A.; Shi, J.; Mulder, M.; Stoeken-Rijsbergen, G.; Drijfhout, J.W.; Huizinga, T.W.J.; Trouw, L.A. & Toes, R.E.M. (2013), The concentration of anticitrullinated protein antibodies in serum and synovial fluid in relation to total immunoglobulin concentrations, Annals of the Rheumatic Diseases 72(6): 1059-1063.
- Habets, K.L.L.; Huizinga, T.W.J. & Toes, R.E.M. (2013), Platelets and autoimmunity, European Journal of Clinical Investigation 43(7): 746-757.
- Muhammad, A.; Wesemael, T. van; Kochi, Y.; Mjaavatten, M.; Wevers-de-Boer, K.; Allaart, C.F.; Trouw, L.A.; Suzuki, A.; Yamamoto, K.; Helm-van Mil, A.H.M. van der; Huizinga, T.W.J.; Toes, R.E.M. & Woude, D. van der (2013), In Rheumatoid Arthritis, Smoking Is Not Primarily Associated With Anti-Citrullinated Protein Antibodies, But With The Presence Of Multiple Autoantibodies, Arthritis and Rheumatism 65: S1024-S1024.
- Liu, B.S.; Stoop, J.N.; Huizinga, T.W. & Toes, R.E.M. (2013), IL-21 Enhances the Activity of the TLR-MyD88-STAT3 Pathway but Not the Classical TLR-MyD88-NF-kappa B Pathway in Human B Cells To Boost Antibody Production, Journal of Immunology 191(8): 4086-4094.
- Trouw, L.A.; Daha, N.; Kurreeman, F.A.S.; Bohringer, S.; Goulielmos, G.N.; Westra, H.J.; Zhernakova, A.; Franke, L.; Stahl, E.A.; Levarht, E.W.N.; Stoeken-Rijsbergen, G.; Verduijn, W.; Roos, A.; Li, Y.; Houwing-Duistermaat, J.J.; Huizinga, T.W.J. & Toes, R.E.M. (2013), Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis, Clinical and Experimental Immunology 173(1): 76-83.
- Gaalen, F.A. van; Verduijn, W.; Roelen, D.L.; Bohringer, S.; Huizinga, T.W.J.; Heijde, D.M. van der & Toes, R.E.M. (2013), Epistasis between two HLA antigens defines a subset of individuals at a very high risk for ankylosing spondylitis, Annals of the Rheumatic Diseases 72(6): 974-978.
- Bouwens, T.; Suwannalai, P.; Scherer, U.; Helm-van Mil, A. van der; Schaardenburg, D. van; Huizinga, T.; Toes, R. & Trouw, L. (2013), Enhanced complement activation by low-avidity anti-citrullinated protein antibodies (ACPA) possibly explains the association with enhanced joint destruction in rheumatoid arthritis, Molecular Immunology 56(3): 252-253.
- Trouw, L.A.; Liu, B.S.; Shi, J.; Jansen, D.T.S.L.; Hegen, M.; Huizinga, T.W.J.; Stoop, J.N. & Toes, R.E.M. (2013), Development Of Antibodies Specific For Carbamylated Protein Precedes Disease Onset In Mice With Collagen-Induced Arthritis, Arthritis and Rheumatism 65: S543-S543.
- Kerkman, P.F.; Rombouts, Y.; Voort, E.I.H. van der; Trouw, L.A.; Huizinga, T.W.J.; Toes, R.E.M. & Scherer, H.U. (2013), Circulating plasmablasts/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis, Annals of the Rheumatic Diseases 72(7): 1259-1263.
- Knevel, R.; Rooy, D.P.C. de; Zhernakova, A.; Grondal, G.; Krabben, A.; Steinsson, K.; Wijmenga, C.; Cavet, G.; Toes, R.E.M.; Huizinga, T.W.J.; Gregersen, P.K. & Helm-van Mil, A.H.M. van der (2013), Association of Variants in IL2RA With Progression of Joint Destruction in Rheumatoid Arthritis, Arthritis and Rheumatism 65(7): 1684-1693.
- Gan, R.W.; Trouw, L.A.; Shi, J.; Toes, R.E.M.; Huizinga, T.W.J.; Zerbe, G.O.; Deane, K.D.; Edison, J.; Gilliland, W.R.; Norris, J.M. & Holers, V.M. (2013), Anti-Carbamylated Protein Antibodies Are Present Prior To The Diagnosis Of Rheumatoid Arthritis and Predict Future Disease Onset, Arthritis and Rheumatism 65: S371-S372.
- Shi, J.; Stadt, L.A. van de; Levarht, E.W.N.; Huizinga, T.W.J.; Hamann, D.; Schaardenburg, D. van; Toes, R.E.M. & Trouw, L.A. (2013), Anti-Carbamylated Protein Antibodies (Anti-CarP) Precede The Onset Of Rheumatoid Arthritis, Arthritis and Rheumatism 65: S391-S391.
- Ioan-Facsinay, A.; Kwekkeboom, J.C.; Westhoff, S.; Giera, M.; Rombouts, Y.; Harmelen, V. van; Huizinga, T.W.J.; Deelder, A.; Kloppenburg, M. & Toes, R.E.M. (2013), Adipocyte-derived lipids modulate CD4(+) T-cell function, European Journal of Immunology 43(6): 1578-1587.
- Klein-Wieringa, I.R.; Andersen, S.N.; Kwekkeboom, J.C.; Giera, M.; Lange-Brokaar, B.J.E. de; Osch, G.J.V.M. van; Zuurmond, A.M.; Stojanovic-Susulic, V.; Nelissen, R.G.H.H.; Pijl, H.; Huizinga, T.W.J.; Kloppenburg, M.; Toes, R.E.M. & Ioan-Facsinay, A. (2013), Adipocytes Modulate the Phenotype of Human Macrophages through Secreted Lipids, Journal of Immunology 191(3): 1356-1363.
- Trouw, L.; Schonkeren, J.; Daha, N.; Levarht, N.; Roos, A.; Ernst-Kruis, M.; Huizinga, T.; Lankester, A. & Toes, R. (2012), A novel non-coding mutation in C1q that causes C1q deficiency associated with recurrent infections, Immunobiology 217(11): 1132-1132.
- Shi, J.; Janssen, G.; Veelen, P. van; Drijfhout, J.; Cerami, A.; Huizinga, T.; Trouw, L.A. & Toes, R.E.M. (2012), Recognition of Citrullinated and Carbamylated Proteins by Human Antibodies: Specificity, Cross-Reactivity and the "AMC-Senshu" Method., Arthritis and Rheumatism 64(10): S757-S757.
- Kerkman, P.F.; Voort, E.I. van der; Trouw, L.A.; Huizinga, T.W.; Toes, R.E. & Scherer, H.U. (2012), PRODUCTION OF ANTI-CITRULLINATED PROTEIN ANTIBODIES BY B CELL SUBSETS ISOLATED FROM PERIPHERAL BLOOD OF PATIENTS WITH RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 71: 312-312.
- Scherer, H.U.; Rombouts, Y.; Ewing, E.; Stadt, L. van de; Selman, M.H.J.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M.; Schaardenburg, D. van & Toes, R.E.M. (2012), Anti-Citrullinated Protein Antibody Specific Fc Glycosylation Patterns in Arthralgia Patients., Arthritis and Rheumatism 64(10): S514-S514.
- Krabben, A.; Wilson, A.G.; Knevel, R.; Zhernakova, A.; Brouwer, E.; Lindqvist, E.; Saxne, T.; Stoeken-Rijsbergen, G.; Nies, J.A.B. van; Rooy, D.P.C. de; Huizinga, T.W.J.; Koeleman, B.P.C.; Toes, R.E.M.; Gregersen, P.K. & Helm-van Mil, A.H.M. van der (2012), Genetic Variants in the IL-4 and IL-4 Receptor Genes in Association with the Severity of Joint Damage in Rheumatoid Arthritis: A Study in Seven Cohorts, Arthritis and Rheumatism 64(10): S389-S389.
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- Klein-Wieringa, I.R.; Kloppenburg, M.; Bastiaansen-Jenniskens, Y.M.; Yusuf, E.; Kwekkeboom, J.C.; El-Bannoudi, H.; Nelissen, R.G.H.H.; Zuurmond, A.; Stojanovic-Susulic, V.; Osch, G.J.V.M. van; Toes, R.E.M. & Ioan-Facsinay, A. (2011), THE INFRAPATELLAR FAT PAD OF OSTEOARTHRITIC PATIENTS HAS AN INFLAMMATORY PHENOTYPE, Annals of the Rheumatic Diseases 70: -.
- Suwannalai, P.; Scherer, H.U.; Woude, D. van der; Ioan-Facsinay, A.; Jol-van der Zijde, C.M.; Tol, M.J.D. van; Drijfhout, J.W.; Huizinga, T.W.J.; Toes, R.E.M. & Trouw, L.A. (2011), Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens., Annals of the Rheumatic Diseases 70(2): 373-9.
- Meeuwisse, C.M.; Linden, M.P. van der; Rullmann, T.A.; Allaart, C.F.; Nelissen, R.; Huizinga, T.W.; Garritsen, A.; Toes, R.E.; Schaik, R. van & Helm-van Mil, A.H. van der (2011), Identification of CXCL13 as a Marker for Rheumatoid Arthritis Outcome Using an In Silico Model of the Rheumatic Joint, Arthritis and Rheumatism 63(5): 1265-1273.
- Klein-Wieringa, I.R.; Kloppenburg, M.; Bastiaansen-Jenniskens, Y.M.; Yusuf, E.; Kwekkeboom, J.C.; El-Bannoudi, H.; Nelissen, R.G.H.H.; Zuurmond, A.; Stojanovic-Susulic, V.; Osch, G.J.V.M. van; Toes, R.E.M. & Ioan-Facsinay, A. (2011), The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype., Annals of the Rheumatic Diseases.
- Willemze, A.; Woude, D. van der; Ghidey, W.; Levarht, E.W.N.; Stoeken-Rijsbergen, G.; Verduyn, W.; Vries, R.R.P. de; Houwing-Duistermaat, J.J.; Huizinga, T.W.J.; Trouw, L.A. & Toes, R.E.M. (2011), The Interaction Between HLA Shared Epitope Alleles and Smoking and Its Contribution to Autoimmunity Against Several Citrullinated Antigens, Arthritis and Rheumatism 63(7): 1823-1832.
- Korotkova, M.; Daha, N.A.; Seddighzadeh, M.; Ding, B.; Catrina, A.I.; Lindblad, S.; Huizinga, T.W.J.; Toes, R.E.M.; Alfredsson, L.; Klareskog, L.; Jakobsson, P.J. & Padyukov, L. (2011), Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis, European Journal of Human Genetics 19(8): 908-914.
- Heemst, J. van; Feitsma, A.L.; Voort, E.I.H. van der; Toes, R.E. & Ioan-Facsinay, A. (2011), IDENTIFICATION OF CITRULLINATED FIBRINOGEN PEPTIDES AS T CELL EPITOPES IN HUMANISED HLA-DR4 TRANSGENIC MICE, Annals of the Rheumatic Diseases 70.
- Vazgiourakis, V.; Zervou, M.; Choulaki, C.; Bertsias, G.; Plant, D.; Trouw, L.A.; Toes, R.E.; Kabouraki, E.; Worthington, J.; Sidiropoulos, P.; Boumpas, D.T. & Goulielmos, G.N. (2011), GENETIC ASSOCIATION AND FUNCTIONAL CONSEQUENCES OF A COMMON SNP IN THE CD40 REGION WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND RHEUMATOID ARTHRITIS IN A HOMOGENEOUS GREEK POPULATION, Annals of the Rheumatic Diseases 70.
- Westerhuis, G.; Pel, M. van; Toes, R.E.M.; Staal, F.J.T. & Fibbe, W.E. (2011), Chimerism levels after stem cell transplantation are primarily determined by the ratio of donor to host stem cells, Blood 117(16): 4400+.
- Samsom, J.N.; Ham, S.M. van; Toes, R.E.M.; Bos, N.A.; Damoiseaux, J.; Baarle, D. van; Loosdrecht, A.A.V. de & Nolte, M.A. (2011), Guiding the action of the immune system: Interactions between the immune system and non-immune tissues NVVI-Dutch society for Immunology Course, Lunteren, March 31st-April 1st, 2010, Immunology Letters 138(1): 1-3.
- Klein-Wieringa, I.R.; Linden, M.P.M. van der; Knevel, R.; Kwekkeboom, J.C.; Beelen, E. van; Huizinga, T.W.J.; Helm-van Mil,A van der; Kloppenburg, M.; Toes, R.E.M. & Ioan-Facsinay, A. (2011), Baseline Serum Adipokine Levels Predict Radiographic Progression in Early Rheumatoid Arthritis, Arthritis and Rheumatism 63(9): 2567-2574.
- Daha, N.A. & Toes, R.E.M. (2011), RHEUMATOID ARTHRITIS Are ACPA-positive and ACPA-negative RA the same disease?, Nature Reviews Rheumatology 7(4): 203-204.
- Toes, R. (2011), THE EVOLUTION OF THE DISEASE-SPECIFIC IMMUNE RESPONSE IN (PRE)-ARTHRITIS: CAN WE IDENTIFY A MASTERSWITCH DETERMINING THE ONSET OF IMMUNE MEDIATED INFLAMMATORY DISEASES?, Inflammation Research 60: 14-14.
- Willemze, A.; Bohringer, S.; Knevel, R.; Levarht, E.W.N.; Stoeken-Rijsbergen, G.; Houwing-Duistermaat, J.J.; Helm-van Mil, A.H.M. van der; Huizinga, T.W.J.; Toes, R.E.M. & Trouw, L.A. (2011), The ACPA Recognition Profile and Sub-Grouping of APCA Positive Rheumatoid Arthritis Patients., Arthritis and Rheumatism 63(10): S849-S850.
- Kollias, G.; Papadaki, P.; Apparailly, F.; Vervoordeldonk, M.J.; Holmdahl, R.; Baumans, V.; Desaintes, C.; Santo, J. di; Distler, J.; Garside, P.; Hegen, M.; Huizinga, T.W.J.; Jungel, A.; Klareskog, L.; McInnes, I.; Ragoussis, I.; Schett, G.; Hart, B. 't; Tak, P.P.; Toes, R.; Berg, W. van den; Wurst, W. & Gay, S. (2011), Animal models for arthritis: innovative tools for prevention and treatment, Annals of the Rheumatic Diseases 70(8): 1357-1362.
- Linden, M.P.M. van der; Batstra, M.R.; Bakker-Jonges, L.E.; Detert, J.; Bastian, H.; Scherer, H.U.; Toes, R.E.M.; Burmester, G.R.; Mjaavatten, M.D.; Kvien, T.K.; Huizinga, T.W.J.; Helm-van Mil, A.H.M. van der & Fdn Quality Med Lab (2011), Toward a Data-Driven Evaluation of the 2010 American College of Rheumatology/European League Against Rheumatism Criteria for Rheumatoid Arthritis Is It Sensible to Look at Levels of Rheumatoid Factor?, Arthritis and Rheumatism 63(5): 1190-1199.
- Wang, J.; Balog, C.I.A.; Stavenhagen, K.; Koeleman, C.A.M.; Scherer, H.U.; Selman, M.H.J.; Deelder, A.M.; Huizinga, T.W.J.; Toes, R.E.M. & Wuhrer, M. (2011), Fc-Glycosylation of IgG1 is Modulated by B-cell Stimuli, Molecular and Cellular Proteomics 10(5).
- Knevel, R.; Krabben, A.; Brouwer, E.; Posthumus, M.D.; Saxne, T.; Lindqvist, E.; Wilson, A.G.; Rooy, D.P.C. de; Daha, N.; Linden, M.P.M. van der; Toes, R.E.M.; Huizinga, T.W.J. & Helm-van Mil, A.H.M. van der (2011), Polymorfisms In IL15 Associate with Progression of Joint Destruction In Rheumatoid Arthritis; A Multi Cohort Study, Arthritis and Rheumatism 63(10): S132-S132.
- Vazgiourakis, V.M.; Zervou, M.I.; Choulaki, C.; Bertsias, G.; Melissourgaki, M.; Yilmaz, N.; Sidiropoulos, P.; Plant, D.; Trouw, L.A.; Toes, R.E.; Kardassis, D.; Yavuz, S.; Boumpas, D.T. & Goulielmos, G.N. (2011), A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis, Annals of the Rheumatic Diseases 70(12): 2184-2190.
- Toes, R.E.M. & Woude, D. van der (2011), ACPA [ANTI-CITRULLINATED PROTEIN ANTIBODIES) AND RHEUMATOID ARTHRITIS, Acta Reumatologica Portuguesa 36(3): 205-207.
- Toes, R. (2011), The evolution of the disease-specific immune response in (pre)-arthritis: can we identify a Masterswitch determining the onset of rheumatoid arthritis?, Immunology 135: 32-32.
- Zervou, M.I.; Vazgiourakis, V.M.; Yilmaz, N.; Kontaki, E.; Trouw, L.A.; Toes, R.E.; Bicakcigil, M.; Boumpas, D.T.; Yavuz, S. & Goulielmos, G.N. (2011), TRAF1/C5, eNOS, C1q, but not STAT4 and PTPN22 gene polymorphisms are associated with genetic susceptibility to systemic lupus erythematosus in Turkey, Human Immunology 72(12): 1210-1213.
- Suwannalai, P.; Trouw, L.A.; Toes, R.E.M. & Huizinga, T.W.J. (2011), Anti-citrullinated protein antibodies (ACPA) in early rheumatoid arthritis.
- Willemze, A.; Bohringer, S.; Knevel, R.; Levarht, E.W.N.; Stoeken-Rijsbergen, G.; Houwing-Duistermaat, J.J.; Helm-van Mil, A.H.M. van der; Huizinga, T.W.J.; Toes, R.E.M. & Trouw, L.A. (2011), The ACPA recognition profile and subgrouping of ACPA-positive RA patients., Annals of the Rheumatic Diseases.
- Trouw, L.A.; Bohringer, S.; Daha, N.A.; Stahl, E.A.; Raychaudhuri, S.; Kurreeman, F.A.; Stoeken-Rijsbergen, G.; Houwing-Duistermaat, J.J.; Huizinga, T.W. & Toes, R.E. (2011), The major risk alleles of age-related macular degeneration (AMD) in CFH do not play a major role in rheumatoid arthritis (RA)., Clinical and Experimental Immunology 166(3): 333-7.
- Linden, M.P.M. van der; Batstra, M.R.; Bakker-Jonges, L.E.; Detert, J.; Bastian, H.; Scherer, H.U.; Toes, R.E.M.; Burmester, G.R.; Mjaavatten, M.D.; Kvien, T.K.; Huizinga, T.W.J.; Helm-van Mil, A.H.M. van der & Fdn Quality Med Lab (2011), Toward a data-driven evaluation of the 2010 American College of Rheumatology/European League Against Rheumatism criteria for rheumatoid arthritis: is it sensible to look at levels of rheumatoid factor?, Arthritis and Rheumatism 63(5): 1190-9.
- Scherer, H.U.; Woude, D. van der; Willemze, A.; Trouw, L.A.; Knevel, R.; Syversen, S.W.; Linden, M.P.M. van der; Lie, B.; Huizinga, T.W.J.; Heijde, D.M.F.M. van der; Helm-van Mil, A.H.M. van der; Kvien, T.K. & Toes, R.E.M. (2011), Distinct ACPA fine specificities, formed under the influence of HLA shared epitope alleles, have no effect on radiographic joint damage in rheumatoid arthritis, Annals of the Rheumatic Diseases 70(8): 1461-1464.
- Vries, R.R.P. de; Woude, D. van der; Houwing, J.J. & Toes, R.E.M. (2011), Genetics of ACPA-positive rheumatoid arthritis: the beginning of the end?, Annals of the Rheumatic Diseases 70: I51-I54.
- Kooi, E. van der; Klarenbeek, N.B.; Guler-Yuksel, M.; Kerstens, P.J.S.M.; Lubbe, P.A.H.M. van der; Westedt, M.L.; Wolde, S. ten; Huizinga, T.W.J.; Dijkmans, B.A.C. & Allaart, C.F. (2011), A decrease in disease activity score (DAS) level is associated with a decrease in health assessment questionnaire (HAQ) score, independent of follow-up duration, during 5 years of tightly controlled treatment: results from the BeSt study, Annals of the Rheumatic Diseases 70(1): 168-171.
- Vries, R.R.P. de; Woude, D. van der; Houwing, J.J. & Toes, R.E.M. (2011), Genetics of ACPA-positive rheumatoid arthritis: the beginning of the end?, Annals of the Rheumatic Diseases 70 Suppl 1: i51-4.
- Suwannalai, P.; Scherer, H.U.; Woude, D. van der; Ioan-Facsinay, A.; Jol-van der Zijde, C.M.; Tol, M.J.D. van; Drijfhout, J.W.; Huizinga, T.W.J.; Toes, R.E.M. & Trouw, L.A. (2011), Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens, Annals of the Rheumatic Diseases 70(2): 373-379.
- Wang J., Han W.G., Foks A.C., Huizinga T.W.J. & Toes R.E.M. (2010), Neutralization of IL-4 reverses the nonresponsiveness of CD4+ T cells to regulatory T-cell induction in non-responder mouse strains, Molecular Immunology 48(1-3): 137-146.
- Vries, B. de; Steup-Beekman, G.M.; Haan, J.; Bollen, E.L.; Luyendijk, J.; Frants, R.R.; Terwindt, G.M.; Buchem, M.A. van; Huizinga, T.W.J.; Maagdenberg, A.M.J.M. van den & Ferrari, M.D. (2010), TREX1 gene variant in neuropsychiatric systemic lupus erythematosus, Annals of the Rheumatic Diseases 69(10): 1886-1887.
- Nies, J.A.B. van; Knevel, R.; Daha, N.; Linden, M.P.M. van der; Gregersen, P.K.; Kern, M.; Cessie, S.; Houwing-Duistermaat, J.J.; Huizinga, T.W.J.; Toes, R.E.M. & Helm-van Mil, A.H.M. van der (2010), The PTPN22 susceptibility risk variant is not associated with the rate of joint destruction in anti-citrullinated protein antibody-positive rheumatoid arthritis, Annals of the Rheumatic Diseases 69(9): 1730U24.
- Kurreeman, F.A.S.; Goulielmos, G.N.; Alizadeh, B.Z.; Rueda, B.; Houwing-Duistermaat, J.; Sanchez, E.; Bevova, M.; Radstake, T.R.; Vonk, M.C.; Galanakis, E.; Ortego, N.; Verduyn, W.; Zervou, M.I.; Roep, B.O.; Dema, B.; Espino, L.; Urcelay, E.; Boumpas, D.T.; Berg, L.H. van den; Wijmenga, C.; Koeleman, B.P.C.; Huizinga, T.W.J.; Toes, R.E.M.; Martin, J.; AADEA Grp & SLEGEN Consortium (2010), The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases, Annals of the Rheumatic Diseases 69(4): 696-699.
- Damjanovska, L.; Thabet, M.M.; Levarth, E.W.N.; Stoeken-Rijsbergen, G.; Voort, E.I. van der; Toes, R.E.M.; Huizinga, T.W.J. & Helm-van Mil, A.H.M. van der (2010), Diagnostic value of anti-MCV antibodies in differentiating early inflammatory arthritis, Annals of the Rheumatic Diseases 69(4): 730-732.
- Yusuf, E.; Marijt, K.A.; Osch, G.J.V.M. van; Zuurmond, A.; Stoianovic-Susulic, V.; Toes, R.E.M.; Kloppenburg, M. & Ioan-Facsinay, A. (2010), IMMUNOLOGICAL CHARACTERISATION OF HOFFA'S FAT PAD IN OSTEOARTHRITIS, Annals of the Rheumatic Diseases 69.
- Charbonnier, L.M.; Han, W.G.H.; Quentin, J.; Huizinga, T.W.J.; Zwerina, J.; Toes, R.E.M.; Jorgensen, C. & Louis-Plence, P. (2010), Adoptive transfer of IL-10-secreting CD4(+)CD49b(+) regulatory T cells suppresses ongoing arthritis, Journal of Autoimmunity 34(4): 390-399.
- Hitchon, C.A.; Chandad, F.; Ferucci, E.D.; Willemze, A.; Ioan-Facsinay, A.; Woude, D. van der; Markland, J.; Robinson, D.; Elias, B.; Newkirk, M.; Toes, R.M.; Huizinga, T.W.J. & El-Gabalawy, H.S. (2010), Antibodies to Porphyromonas gingivalis Are Associated with Anticitrullinated Protein Antibodies in Patients with Rheumatoid Arthritis and Their Relatives, Journal of Rheumatology 37(6): 1105-1112.
- Snir, O.; Widhe, M.; Hermansson, M.; Spee, C. von; Lindberg, J.; Hensen, S.; Lundberg, K.; Engstrom, A.; Venables, P.J.W.; Toes, R.E.M.; Holmdahl, R.; Klareskog, L. & Malmstrom, V. (2010), Antibodies to Several Citrullinated Antigens Are Enriched in the Joints of Rheumatoid Arthritis Patients, Arthritis and Rheumatism 62(1): 44-52.
- Han, W.G.H.; Voort, E.I.H. van der; Bannoudi, H. el; Louis-Plence, P.; Huizinga, T.W.J. & Toes, R.E.M. (2010), DX5(+) CD4(+) T cells modulate cytokine production by CD4(+) T cells towards IL-10 via the production of IL-4, European Journal of Immunology 40(10): 2731-2740.
- Woude, D. van der; Dahlqvist, S.R.; Ioan-Facsinay, A.; Onnekink, C.; Schwarte, C.M.; Verpoort, K.N.; Drijfhout, J.W.; Huizinga, T.W.J.; Toes, R.E.M. & Pruijn, G.J.M. (2010), Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis, Annals of the Rheumatic Diseases 69(8): 1554-1561.
- Seddighzadeh, M.; Korotkova, M.; Kallberg, H.; Ding, B.; Daha, N.; Kurreeman, F.A.S.; Toes, R.E.M.; Huizinga, T.W.; Catrina, A.I.; Alfredsson, L.; Klareskog, L. & Padyukov, L. (2010), Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis, European Journal of Human Genetics 18(7): 821-826.
- Habets, K.L.L.; Frodermann, V.; Foks, A.C.; Puijvelde, G.H.M. van; Toes, R.E.M.; Berkel, T.J.C. van & Kuiper, J. (2010), Foam cell formation affects MHCI processing and presentation in vitro while hypercholesteremia induces a DC-like phenotype in macrophages in vivo, Atherosclerosis 213(1): E18E18.
- Helm-van Mil, A.H.M. van der; Toes, R.E.M. & Huizinga, T.W.J. (2010), Genetic variants in the prediction of rheumatoid arthritis, Annals of the Rheumatic Diseases 69(9): 1694-1696.
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- Scherer, H.U.; Woude, D. van der; Ioan-Facsinay, A.; Bannoudi, H. el; Trouw, L.A.; Wang, J.; Haupl, T.; Burmester, G.R.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M. & Toes, R.E.M. (2010), Glycan Profiling of Anti-Citrullinated Protein Antibodies Isolated From Human Serum and Synovial Fluid, Arthritis and Rheumatism 62(6): 1620-1629.
- Woude, D. van der; Lie, B.A.; Lundstrom, E.; Balsa, A.; Feitsma, A.L.; Houwing-Duistermaat, J.J.; Verduijn, W.; Nordang, G.B.N.; Alfredsson, L.; Klareskog, L.; Pascual-Salcedo, D.; Gonzalez-Gay, M.A.; Lopez-Nevot, M.A.; Valero, F.; Roep, B.O.; Huizinga, T.W.J.; Kvien, T.K.; Martin, J.; Padyukov, L.; Vries, R.R.P. de & Toes, R.E.M. (2010), Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: a meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in four European populations., Arthritis and Rheumatism 62(5): 1236-45.
- Feitsma, A.L.; Voort, E.I.H. van der; Franken, K.L.M.C.; Bannoudi, H. el; Elferink, B.G.; Drijfhout, J.W.; Huizinga, T.W.J.; Vries, R.R.P. de; Toes, R.E.M. & Ioan-Facsinay, A. (2010), Identification of Citrullinated Vimentin Peptides as T Cell Epitopes in HLA-DR4-Positive Patients With Rheumatoid Arthritis, Arthritis and Rheumatism 62(1): 117-125.
- Scherer, H.U.; Pel, M. van & Toes, R.E.M. (2010), Mesenchymal stem cells in autoimmune diseases: hype or hope?, Arthritis Research and Therapy 12(3).
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- Habets, K.L.L.; Puijvelde, G.H.M. van; Duivenvoorde, L.M. van; Wanrooij, E.J.A. van; Vos, P. de; Tervaert, J.W.C.; Berkel, T.J.C. van; Toes, R.E.M. & Kuiper, J. (2010), Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice, Cardiovascular Research 85(3): 622-630.
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- Kooloos, W.M.; Wessels, J.A.M.; Straaten, T. van der; Allaart, C.F.; Huizinga, T.W.J. & Guchelaar, H.J. (2010), Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis, Pharmacogenomics 11(2): 163-175.
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- Wang, J.; Han, W.G.H.; Foks, A.C.; Huizinga, T.W.J. & Toes, R.E.M. (2010), Neutralization of IL-4 reverses the nonresponsiveness of CD4(+) T cells to regulatory T-cell induction in non-responder mouse strains, Molecular Immunology 48(1-3): 137-146.
- Scherer, H.U.; Woude, D. van der; Ioan-Facsinay, A.; Bannoudi, H. el; Trouw, L.A.; Wang, J.; Haupl, T.; Burmester, G.R.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M. & Toes, R.E.M. (2010), Glycan profiling of anti-citrullinated protein antibodies (ACPA) isolated from human serum and synovial fluid., Arthritis and Rheumatism.
- Emmer, B.J.; Osch, M.J. van; Wu, O.; Steup-Beekman, G.M.; Steens, S.C.; Huizinga, T.W.; Buchem, M.A. van & Grond, J. van der (2010), Perfusion MRI in Neuro-Psychiatric Systemic Lupus Erthemathosus, Journal of Magnetic Resonance Imaging 32(2): 283-288.
- Han, W.G.H.; Voort, E.I.H. van der; Bannoudi, H. el; Louis-Plence, P.; Huizinga, T.W.J. & Toes, R.E.M. (2010), DX5(+)CD4(+) T cells modulate cytokine production by CD4(+) T cells towards IL-10 via the production of IL-4., European Journal of Immunology 40(10): 2731-40.
- Wang, J.; Han, W.G.H.; Foks, A.C.; Huizinga, T.W.J. & Toes, R.E.M. (2010), Neutralization of IL-4 reverses the nonresponsiveness of CD4+ T cells to regulatory T-cell induction in non-responder mouse strains.
- Linden, M.P.M. van der; Batstra, M.R.; Bakker-Jonges, L.E.; Detert, J.; Bastian, H.; Scherer, H.U.; Toes, R.E.M.; Burmester, G.R.; Mjaavatten, M.D.; Kvien, T.K.; Huizinga, T.W.J.; Helm-van Mil, A.H.M. van der & Fdn Quality Med Lab (2010), Towards a data-driven evaluation of the 2010 ACR/EULAR criteria for rheumatoid arthritis: Is it sensible to look at levels of rheumatoid factor?, Arthritis and Rheumatism.
- Wauben, M.H.M.; Toes, R.E.M.; Bos, N.A.; Damoiseaux, J.; Ham, S.M. van; Loosdrecht, A.A. van de & Samsom, J.N. (2010), Sensing and signaling by the immune system NVVI-Dutch Society for Immunology Course, Lunteren, April 2-3, 2009, Immunology Letters 128(1): 1-3.
- Klein-Wieringa, I.R.; Kloppenburg, M.; Bastiaansen-Jenniskens, Y.M.; Yusuf, E.; Kwekkeboom, J.C.; El-Bannoudi, H.; Nelissen, R.G.; Zuurmond, A.M.; Stojanovic-Susulic, V.; Osch, G.J. van; Toes, R.E. & Ioan-Facsinay, A. (2010), THE INFRAPATELLAR FAT PAD OF OSTEOARTHRITIC PATIENTS HAS AN INFLAMMATORY PHENOTYPE, Osteoarthritis and Cartilage 18: S14S15.
- Kurreeman, F.A.S.; Goulielmos, G.N.; Alizadeh, B.Z.; Rueda, B.; Houwing-Duistermaat, J.; Sanchez, E.; Bevova, M.; Radstake, T.R.; Vonk, M.C.; Galanakis, E.; Ortego, N.; Verduyn, W.; Zervou, M.I.; Roep, B.O.; Dema, B.; Espino, L.; Urcelay, E.; Boumpas, D.T.; Berg, L.H. van den; Wijmenga, C.; Koeleman, B.P.C.; Huizinga, T.W.J.; Toes, R.E.M.; Martin, J.; AADEA Grp & SLEGEN Consortium (2010), The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases., Annals of the Rheumatic Diseases 69(4): 696-699.
- Guler-Yuksel, M.; Allaart, C.F.; Watt, I.; Goekoop-Ruiterman, Y.P.M.; Vries-Bouwstra, J.K. de; Schaardenburg, D. van; Krugten, M.V. van; Dijkmans, B.A.C.; Huizinga, T.W.J.; Lems, W.F. & Kloppenburg, M. (2010), Treatment with TNF-alpha inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis, Osteoarthritis and Cartilage 18(10): 1256-1262.
- Goekoop-Ruiterman, Y.P.M.; Vries-Bouwstra, J.K. de; Kerstens, P.J.S.M.; Nielen, M.M.J.; Vos, K.; Schaardenburg, D. van; Speyer, I.; Seys, P.E.H.; Breedveld, F.C.; Allaart, C.F. & Dijkmans, B.A.C. (2010), DAS-driven therapy versus routine care in patients with recent-onset active rheumatoid arthritis, Annals of the Rheumatic Diseases 69(1): 65-69.
- Scherer, H.U.; Linden, M.P.M. van der; Kurreeman, F.A.S.; Stoeken-Rijsbergen, G.; Cessie, S. le; Huizinga, T.W.J.; Helm-van Mil, A.H. van der & Toes, R.E.M. (2010), Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis, Annals of the Rheumatic Diseases 69(3): 567-570.
- Scherer, H.U.; Linden, M.P.M. van der; Kurreeman, F.A.S.; Stoeken-Rijsbergen, G.; Cessie, S. le; Huizinga, T.W.J.; Helm-van Mil, A.H. van der & Toes, R.E.M. (2010), Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis., Annals of the Rheumatic Diseases 69(3): 567-70.
- Woude, D. van der; Alemayehu, W.G.; Daha, N.A.; Verduyn, W.; Vries, R.R.P. de; Houwing-Duistermaat, J.J.; Huizinga, T.W.J. & Toes, R.E.M. (2010), A GENE - ENVIRONMENT INTERACTION BETWEEN HLA SE ALLELES AND SMOKING AFFECTS THE REACTIVITY OF ACPA TO VARIOUS CITRULLINATED ANTIGENS, Annals of the Rheumatic Diseases 69.
- Emmer, B.J.; Veer, I.M.; Steup-Beekman, G.M.; Huizinga, T.W.J.; Grond, J. van der & Buchem, M.A. van (2010), Tract-Based Spatial Statistics on Diffusion Tensor Imaging in Systemic Lupus Erythematosus Reveals Localized Involvement of White Matter Tracts, Arthritis and Rheumatism 62(12): 3716-3721.
- Guler-Yuksel, M.; Klarenbeek, N.B.; Goekoop-Ruiterman, Y.P.M.; Vries-Bouwstra, J.K. de; Kooij, S.M. van der; Gerards, A.H.; Ronday, H.K.; Huizinga, T.W.J.; Dijkmans, B.A.C.; Allaart, C.F. & Lems, W.F. (2010), Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis, Arthritis Research and Therapy 12(3).
- Visser, K.; Goekoop-Ruiterman, Y.P.M.; Vries-Bouwstra, J.K. de; Ronday, H.K.; Seys, P.E.H.; Kerstens, P.J.S.M.; Huizinga, T.W.J.; Dijkmans, B.A.C. & Allaart, C.F. (2010), A matrix risk model for the prediction of rapid radiographic progression in patients with rheumatoid arthritis receiving different dynamic treatment strategies: post hoc analyses from the BeSt study, Annals of the Rheumatic Diseases 69(7): 1333-1337.
- Klarenbeek, N.B.; Kooij, S.M. van der; Huizinga, T.J.W.; Goekoop-Ruiterman, Y.P.M.; Hulsmans, H.M.J.; Krugten, M.V. van; Speyer, I.; Vries-Bouwstra, J.K. de; Kerstens, P.J.S.M.; Huizinga, T.W.J.; Dijkmans, B.A.C. & Allaart, C.F. (2010), Blood pressure changes in patients with recent-onset rheumatoid arthritis treated with four different treatment strategies: a post hoc analysis from the BeSt trial, Annals of the Rheumatic Diseases 69(7): 1342-1345.
- Woude, D. van der; Alemayehu, W.G.; Verduijn, W.; Vries, R.R.P. de; Houwing-Duistermaat, J.J.; Huizinga, T.W.J. & Toes, R.E.M. (2010), Gene-environment interaction influences the reactivity of autoantibodies to citrullinated antigens in rheumatoid arthritis, Nature Genetics 42(10): 814-816.
- Bijl, A.E. van der & Allaart, C.F. (2010), Efficacy of intraarticular infliximab administration in patients with recurrent gonarthritis: comment on the article by van der Bijl et al Reply, ARTHRITIS CARE & RESEARCH 62(2): 291-292.
- Cui, J.; Saevarsdottir, S.; Thomson, B.; Padyukov, L.; Helm-van Mil, A.H.M. van der; Nititham, J.; Hughes, L.B.; Vries, N. de; Raychaudhuri, S.; Alfredsson, L.; Askling, J.; Wedren, S.; Ding, B.; Guiducci, C.; Wolbink, G.J.; Crusius, J.B.A.; Horst-Bruinsma, I.E. van der; Herenius, M.; Weinblatt, M.E.; Shadick, N.A.; Worthington, J.; Batliwalla, F.; Kern, M.; Morgan, A.W.; Wilson, A.G.; Isaacs, J.D.; Hyrich, K.; Seldin, M.F.; Moreland, L.W.; Behrens, T.W.; Allaart, C.F.; Criswell, L.A.; Huizinga, T.W.J.; Tak, P.P.; Bridges, S.L.; Toes, R.E.M.; Barton, A.; Klareskog, L.; Gregersen, P.K.; Karlson, E.W.; Plenge, R.M. & Biol Rheumatoid Arthrit Genet & Ge (2010), Rheumatoid Arthritis Risk Allele PTPRC Is Also Associated With Response to Anti-Tumor Necrosis Factor alpha Therapy, Arthritis and Rheumatism 62(7): 1849-1861.
- Allaart, C.F. (2010), When to start which DMARDs in rheumatoid arthritis?, Scandinavian Journal of Rheumatology 39: 13-13.
- Ioan-Facsinay, A.; El-Bannoudi, H.; Scherer, H.U.; Woude, D. van der; Menard, H.A.; Lora, M.; Trouw, L.A.; Huizinga, T.W.J. & Toes, R.E.M. (2010), ANTI-CCP ANTIBODIES ARE A COLLECTION OF ACPA THAT ARE CROSS-REACTIVE TO MULTIPLE CITRULLINATED ANTIGENS, Annals of the Rheumatic Diseases 69.
- Marques, R.B.; Thabet, M.M.; White, S.J.; Houwing-Duistermaat, J.J.; Bakker, A.M.; Hendriks, G.J.; Zhernakova, A.; Huizinga, T.W.; Helm-van Mil, A.H. van der & Toes, R.E. (2010), Genetic Variation of the Fc Gamma Receptor 3B Gene and Association with Rheumatoid Arthritis, PLoS ONE 5(10).
- Woude, D. van der; Lie, B.A.; Lundstrom, E.; Balsa, A.; Feitsma, A.L.; Houwing-Duistermaat, J.J.; Verduijn, W.; Nordang, G.B.N.; Alfredsson, L.; Klareskog, L.; Pascual-Salcedo, D.; Gonzalez-Gay, M.A.; Lopez-Nevot, M.A.; Valero, F.; Roep, B.O.; Huizinga, T.W.J.; Kvien, T.K.; Martin, J.; Padyukov, L.; Vries, R.R.P. de & Toes, R.E.M. (2010), Protection Against Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis Is Predominantly Associated With HLA-DRB1*1301 A Meta-Analysis of HLA-DRB1 Associations With Anti-Citrullinated Protein Antibody-Positive and Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis in Four European Populations, Arthritis and Rheumatism 62(5): 1236-1245.
- Cohen, D.; Berger, S.P.; Steup-Beekman, G.M.; Bloemenkamp, K.W.M. & Bajema, I.M. (2010), Diagnosis and management of the antiphospholipid syndrome., BMJ 340: c2541.
- Seghers L, van Weel V, van Bergen J, Toes R, Hellingman A, de Vries M, van Hinsbergh V & Quax P (2009), C57BL/6 NK Cell Gene Complex Crucially Involved in General Vascular Remodelling, Circulation 120(18): S1146S1146.
- Toes RE & Huizinga TW (2009), Autoimmune responses in the rheumatoid synovium.
- van der Woude D, Houwing-Duistermaat JJ, Toes REM, Huizinga TWJ, Thomson W, Worthington J, van der Helm-van Mil AHM & de Vries RRP (2009), Quantitative Heritability of Anti-Citrullinated Protein Antibody-Positive and Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis, Arthritis and Rheumatism 60(4): 916-923.
- Lebrec JJ, Huizinga TW, Toes RE, Houwing-Duistermaat JJ & van Houwelingen HC (2009), Integration of gene ontology pathways with North American Rheumatoid Arthritis Consortium genome-wide association data via linear modeling., BMC Proceedings 3 Suppl 7: S94.
- Westerhuis G, Maas WGE, Toes REM & Fibbe WE (2009), Persisting NK cell alloreactivity in the presence of long-term stable hematopoietic chimerism, Experimental Hematology 37(6): 739-743.
- van der Woude D, Houwing-Duistermaat JJ, Toes REM, Huizinga TWJ, Thomson W, Worthington J, van der Helm-van Mil AHM & de Vries RRP (2009), Quantitative Heritability of Anti-Citrullinated Protein Antibody-Positive and Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis, Arthritis and Rheumatism 60(4): 916-923.
- Trouw LA, Haisma EM, Levarht EWN, van der Woude D, Ioan-Facsinay A, Daha VR, Huizinga TWJ & Toes RE (2009), Anti-Cyclic Citrullinated Peptide Antibodies From Rheumatoid Arthritis Patients Activate Complement via Both the Classical and Alternative Pathways, Arthritis and Rheumatism 60(7): 1923-1931.
- Trouw LA, Haisma EM, Levarht EW, van der Woude D, Ioan-Facsinay A, Daha MR, Huizinga TW & Toes RE (2009), Human anti-citrullinated protein antibodies (ACPA) not only activate the classical- but also the alternative complement pathway, Molecular Immunology 46(14): 2828-2828.
- van der Woude D, Young A, Jayakumar K, Mertens BJ, Toes REM, van der Heijde D, Huizinga TWJ & van der Helm-van Mil AHM (2009), Prevalence of and Predictive Factors for Sustained Disease-Modifying Antirheumatic Drug-Free Remission in Rheumatoid Arthritis Results From Two Large Early Arthritis Cohorts, Arthritis and Rheumatism 60(8): 2262-2271.
- van der Woude D, Young A, Jayakumar K, Mertens BJ, Toes REM, van der Heijde D, Huizinga TWJ & van der Helm-van Mil AHM (2009), Prevalence of and Predictive Factors for Sustained Disease-Modifying Antirheumatic Drug-Free Remission in Rheumatoid Arthritis Results From Two Large Early Arthritis Cohorts, Arthritis and Rheumatism 60(8): 2262-2271.
- van der Linden MPM, van der Woude D, Ioan-Facsinay A, Levarht EWN, Stoeken-Rijsbergen G, Huizinga TWJ, Toes REM & van der Helm-van Mil AHM (2009), Value of Anti-Modified Citrullinated Vimentin and Third-Generation Anti-Cyclic Citrullinated Peptide Compared With Second-Generation Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor in Predicting Disease Outcome in Undifferentiated Arthritis and Rheumatoid Arthritis, Arthritis and Rheumatism 60(8): 2232-2241.
- van der Woude D, Young A, Jayakumar K, Mertens BJ, Toes REM, van der Heijde D, Huizinga TWJ & van der Helm-van Mil AHM (2009), Prevalence of and Predictive Factors for Sustained Disease-Modifying Antirheumatic Drug-Free Remission in Rheumatoid Arthritis Results From Two Large Early Arthritis Cohorts, Arthritis and Rheumatism 60(8): 2262-2271.
- Albers HM, Kurreeman FA, Stoeken-Rijsbergen G, Brinkman DM, Kamphuis SS, van Rossum MA, Girschick HJ, Wouters C, Saurenmann RK, Hoppenreijs E, Slagboom P, Houwing-Duistermaat JJ, Verduijn W, Huizinga TW, Ten Cate R, Toes RE & Schilham MW (2009), Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis., Arthritis and Rheumatism 60(3): 901-4.
- van der Woude D, Houwing-Duistermaat JJ, Toes REM, Huizinga TWJ, Thomson W, Worthington J, van der Helm-van Mil AHM & de Vries RRP (2009), Quantitative Heritability of Anti-Citrullinated Protein Antibody-Positive and Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis, Arthritis and Rheumatism 60(4): 916-923.
- Scherer HU, van der Linden MP, Kurreeman FA, Stoeken-Rijsbergen G, le Cessie S, Huizinga TW, van der Helm-van Mil AH & Toes RE. (2009), Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis., Annals of the Rheumatic Diseases.
- van der Woude D, Young A, Jayakumar K, Mertens BJ, Toes REM, van der Heijde D, Huizinga TWJ & van der Helm-van Mil AHM (2009), Prevalence of and Predictive Factors for Sustained Disease-Modifying Antirheumatic Drug-Free Remission in Rheumatoid Arthritis Results From Two Large Early Arthritis Cohorts, Arthritis and Rheumatism 60(8): 2262-2271.
- van der Woude D, Houwing-Duistermaat JJ, Toes RE, Huizinga TW, Thomson W, Worthington J, van der Helm-van Mil AH & de Vries RR (2009), Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis., Arthritis and Rheumatism 60(4): 916-23.
- Westerhuis G, Maas WG, Toes RE & Fibbe WE (2009), Persisting NK cell alloreactivity in the presence of long-term stable hematopoietic chimerism.
- Scherer HU, Wang J, Toes REM, van der Woude D, Koeleman CAM, de Boer AR, Huizinga TWJ, Deelder AM & Wuhrer M (2009), Immunoglobulin 1 (IgG1) Fc-glycosylation profiling of anti-citrullinated peptide antibodies from human serum, PROTEOMICS - Clinical Applications 3(1): 106-115.
- Han WG, Schuurhuis DH, Fu N, Camps M, van Duivenvoorde LM, Louis-Plence P, Franken KL, Huizinga TW, Melief CJ, Toes RE & Ossendorp F (2009), DC-induced CD8(+) T-cell response is inhibited by MHC class II-dependent DX5(+)CD4(+) Treg., European Journal of Immunology 39(7): 1765-73.
- Daha NA, Kurreeman FAS, Marques RB, Stoeken-Rijsbergen G, Verduijn W, Huizinga TWJ & Toes REM (2009), Confirmation of STAT4, IL2/IL21, and CTLA4 Polymorphisms in Rheumatoid Arthritis, Arthritis and Rheumatism 60(5): 1255-1260.
- Han, W.G.H.; Schuurhuis, D.H.; Fu, N.; Camps, M.; Duivenvoorde, L.M. van; Louis-Plence, P.; Franken, K.L.M.C.; Huizinga, T.W.J.; Melief, C.J.M.; Toes, R.E.M. & Ossendorp, F. (2009), DC-induced CD8(+) T-cell response is inhibited by MHC class II-dependent DX5(+)CD4(+) Treg, European Journal of Immunology 39(7): 1765-1773.
- Teng YKO, Levarht EWN, Toes REM, Huizinga TWJ & van Laar JM (2009), Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation, Annals of the Rheumatic Diseases 68(6): 1011-1016.
- Toes REM & Huizinga TWJ (2009), Autoimmune Responses in the Rheumatoid Synovium, PLoS Medicine 6(1): 15-16.
- Kurreeman FAS, Daha NA, Chang M, Catanese JJ, Begovich AB, Huizinga TWJ & Toes REM (2009), Association of IL2RA and IL2RB with rheumatoid arthritis: a replication study in a Dutch population, Annals of the Rheumatic Diseases 68(11): 1789-1790.
- Thabet MM, Huizinga TWJ, Marques RB, Stoeken-Rijsbergen G, Bakker AM, Kurreeman FA, White SJ, Toes REM & van der Helm-van Mil AHM (2009), Contribution of Fc gamma receptor IIIA gene 158V/F polymorphism and copy number variation to the risk of ACPA-positive rheumatoid arthritis, Annals of the Rheumatic Diseases 68(11): 1775-1780.
- Albers HM, Kurreeman FAS, Stoeken-Rijsbergen G, Brinkman DMC, Kamphuis SSM, van Rossum MAJ, Girschick HJ, Wouters C, Saurenmann RK, Hoppenreijs E, Slagboom P, Houwing-Duistermaat JJ, Verduijn W, Huizinga TWJ, ten Cate R, Toes REM & Schilham MW (2009), Association of the Autoimmunity Locus 4q27 With Juvenile Idiopathic Arthritis, Arthritis and Rheumatism 60(3): 901-904.
- van der Linden MPM, Feitsma AL, le Cessie S, Kern M, Olsson LM, Raychaudhuri S, Begovich AB, Chang M, Catanese JJ, Kurreeman FAS, van Nies J, van der Heijde DM, Gregersen PK, Huizinga TWJ, Toes REM & van der Helm-van Mil AHM (2009), Association of a Single-Nucleotide Polymorphism in CD40 With the Rate of Joint Destruction in Rheumatoid Arthritis, Arthritis and Rheumatism 60(8): 2242-2247.
- Teng YKO, Levarht EWN, Toes REM, Huizinga TWJ & van Laar JM (2009), Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation, Annals of the Rheumatic Diseases 68(6): 1011-1016.
- Teng, Y.K.O.; Levarht, E.W.N.; Toes, R.E.M.; Huizinga, T.W.J. & Laar, J.M. van (2009), Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation, Annals of the Rheumatic Diseases 68(6): 1011-1016.
- van Bergen J, Kooy-Winkelaar EMC, van Dongen H, van Gaalen FA, Thompson A, Huizinga TWJ, Feltkamp MCW, Toes REM & Koning F (2009), Functional Killer Ig-Like Receptors on Human Memory CD4(+) T Cells Specific for Cytomegalovirus, Journal of Immunology 182(7): 4175-4182.
- van der Linden MP, Feitsma AL, le Cessie S, Kern M, Olsson LM, Raychaudhuri S, Begovich AB, Chang M, Catanese JJ, Kurreeman FA, van Nies J, van der Heijde DM, Gregersen PK, Huizinga TW, Toes RE & van der Helm-Van Mil AH (2009), Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis., Arthritis and Rheumatism 60(8): 2242-7.
- Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JBA, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TWJ, Kastner DL, Ke XY, Kurreeman FAS, Lee AT, Liu XD, Li YH, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AHM, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG & Wolbink GJ (2009), Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk, Nature Genetics 41(12): 1313U76.
- Damjanovska L, Thabet MM, Levarht EW, Stoeken-Rijsbergen G, van der Voort EI, Toes RE, Huizinga TW & van der Helm-van Mil AH. (2009), The diagnostic value of anti-MCV antibodies in differentiating early inflammatory arthritis. , Annals of the Rheumatic Diseases.
- Wang J, Huizinga TWJ & Toes REM (2009), De Novo Generation and Enhanced Suppression of Human CD4(+)CD25(+) Regulatory T Cells by Retinoic Acid, Journal of Immunology 183(6): 4119-4126.
- van der Woude D, Young A, Jayakumar K, Mertens BJ, Toes RE, van der Heijde D, Huizinga TW & van der Helm-van Mil AH (2009), Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: results from two large early arthritis cohorts., Arthritis and Rheumatism 60(8): 2262-71.
- Wang J, Huizinga TW & Toes RE (2009), De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid.
- Trouw LA, Haisma EM, Levarht EW, van der Woude D, Ioan-Facsinay A, Daha MR, Huizinga TW & Toes RE (2009), Human anti-citrullinated protein antibodies (ACPA) not only activate the classical- but also the alternative complement pathway, Molecular Immunology 46(14): 2828-2828.
- Trouw LA, Haisma EM, Levarht EW, van der Woude D, Ioan-Facsinay A, Daha MR, Huizinga TW & Toes RE (2009), Human anti-citrullinated protein antibodies (ACPA) not only activate the classical- but also the alternative complement pathway, Molecular Immunology 46(14): 2828-2828.
- Thabet MM, Huizinga TW, Marques RB, Stoeken-Rijsbergen G, Bakker AM, Kurreeman FA, White SJ, Toes RE & van der Helm-van Mil AH (2009), Contribution of Fcgamma receptor IIIA gene 158V/F polymorphism and copy number variation to the risk of ACPA-positive rheumatoid arthritis., Annals of the Rheumatic Diseases 68(11): 1775-80.
- Albers H, Kurreeman F, Houwing-Duistermaat J, Brinkman D, Kamphuis S, Girschick H, Wouters C, van Rossum M, Verduyn W, Toes R, Huizinga T, Schilham M & ten Cate R (2008), The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis, Arthritis and Rheumatism 58(9).
- van der Woude D, Holiwing-Duistermak JJ, Toes REM, Huizinga TWJ, Thomson W, Worthington J, van der Helm-van Mil AHM & de Vries RRP (2008), Quantitative heritability and contribution of predisposing HLA Alleles to ACPA-positive and ACPA-negative rheumatoid arthritis, Arthritis and Rheumatism 58(9).
- Kurreeman FAS, Rocha D, Houwing-Duistermaat J, Vrijmoet S, Teixeira VH, Migliorini P, Balsa A, Westhovens R, Barrera P, Alves H, Vaz C, Fernandes M, Pascual-Saicedo D, Michou L, Bombardieri S, Radstake T, van Riel P, van de Putte L, Lopes-Vaz A, Prum B, Bardin T, Gut I, Cornelis F, Huizinga TWJ, Petit-Teixeira E & Toes REM (2008), Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study, Arthritis and Rheumatism 58(9).
- Mil AHMVDHV, Padyukov L, Toes RM, Klareskog L & Huizinga TWJ (2008), Genome-wide single-nucleotide polymorphism studies in rheumatology: Hype or hope?, Arthritis and Rheumatism 58(9).
- Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FAS, Chang M, Catanese JJ, Ding B, Wong S, Mil AHMV, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JBA, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TWJ, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes REM, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ & Plenge RM (2008), Common variants at CD40 and other loci confer risk of rheumatoid arthritis, Nature Genetics 40(10).
- Albers HM, Kurreeman FAS, Houwing-Duistermaat JJ, Brinkman DMC, Kamphuis SSM, Girschick HJ, Wouters C, Van Rossum MAJ, Verduijn W, Toes REM, Huizinga TWJ, Schilham MW & ten Cate R (2008), The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis, Annals of the Rheumatic Diseases 67(11).
- Ioan-Facsinay A, Willemze A, Robinson DB, Peschken CA, Markland J, van der Woude D, Elias B, Menard HA, Newkirk M, Fritzler MJ, Toes REM, Huizinga TWJ & El-Gabalawy HS (2008), Marked Differences in Fine Specificity and Isotype Usage of the Anti-Citrullinated Protein Antibody in Health and Disease, Arthritis and Rheumatism 58(10).
- Verpoort KN, Loan A, Pruijn GJM & Toes REM (2008), An intriguing relationship between the immune response to citrullinated vimentin and the HLA shared epitope: comment on the article by Verpoort et al Reply, Arthritis and Rheumatism 58(10).
- Chang M, Rowland CM, Garcia VE, Schrodi SJ, Catanese JJ, Mil AHMVDHV, Ardlie KG, Amos CI, Criswell LA, Kastner DL, Gregersen PK, Kurreeman FAS, Toes REM, Huizinga TWJ, Seldin MF & Begovich AB (2008), A Large-Scale Rheumatoid Arthritis Genetic Study Identifies Association at Chromosome 9q33.2, PLoS Genetics 4(6).
- van der Woude D, Young A, Brand R, Toes REM, Huizinga TWJ & Mil AHMVDHV (2008), Prevalence and predictive factors for DMARD-free remission in RA: Lessons from two large early arthritis cohorts, Arthritis and Rheumatism 58(9).
- Raychaudhuri S, Remmers EF, Lee AT, Korman BD, Padyukov L, Kurreeman FAS, Mil AHMVDHV, Coblyn J, Criswell LA, Amos CI, Seldins MF, Kastner DL, Alfredsson L, Huzinga TWJ, Shadick NA, Weinblatt ME, Worthington J, Seielstad M, Toes REM, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ & Plenge RM (2008), A common variant at the CD40 locus confers risk of rheumatoid, Arthritis and Rheumatism 58(9).
- van der Woude D, Ioan-Facsinay A, Schwarte C, Stoeken-Rijsbergen G, Onnekink C, Drijfhout JW, Huizinga TWJ, Toes REM & Pruijn GJM (2008), Fine specificity of the anti-citrullinated protein antibody response in relationship to the disease course of rheumatoid arthritis, Arthritis and Rheumatism 58(9).
- Scherer HU, van der Woude D, Koeleman CA, de Boer AR, Huizinga TWJ, Deelder AM, Wuhrer M & Toes REM (2008), Glycan profiling of anti-citrullinated protein antibodies (ACPA) reveals profound differences in glycosylation between ACPA and serum, Arthritis and Rheumatism 58(9).
- Feitsma A, Worthington J, Var der Helm-Van Mil A, Plant D, Thomson W, Ursum J, Van Schaardenburg D, Van Der Horst-Bruinsma I, Van Rood J, Huizinga T, Toes R & De Vries R (2008), Protective effect of non-inherited maternal HLA-DR antigens on rheumatoid arthritis development, Annals of the Rheumatic Diseases 67.
- Kurreeman F, Padyukov L, Marques R, Schrodi S, Seddighzadeh M, Stoeken-Rijsbergen G, Van der Helm-Van Mil A, Allaart C, Verduyn W, Housing-Duistermaat J, Alsfredsson L, Begovich A, Petit-Texeira E, Cornelis F, Klareskog L, Huizinga T & Toes R (2008), Association and linkage of the TRAF1/C5 region with specific subsets of rheumatoid arthritis, Annals of the Rheumatic Diseases 67.
- Thabet M, Van der Helm-Van Mil A, Marques R, Bakker A, White S, Houwing-Duistermaat J, Toes R & Huizinga T (2008), Lower copy number of FC gamma receptor 3B gene is associated with rheumatoid arthritis, Annals of the Rheumatic Diseases 67.
- Charbonnier LM, Han W, Quentin J, Huizinga T, Toes R, Jorgensen C & Louis-Plence P (2008), Adoptive transfer of CD4+CD49b+ regulatory T cells expanded by immature dendritic cells reverse symptoms of established arthritis, Annals of the Rheumatic Diseases 67.
- Scherer H, Van Mierlo G, Hameetman M, Morgan M, Flierman R, Huizinga T & Toes R (2008), CD4+CD25+ regulatory T cells directly inhibit inflammation by shedding of sTNFRII, Annals of the Rheumatic Diseases 67.
- Van der Woude D, Stoeken-Rijsbergen G, Verpoort KN, Huizing TW, Pruijn GJ & Toes RE (2008), Fine specificity of the anti-citrullinated protein antibody response at different stages of the disease course of rheumatoid arthritis, Annals of the Rheumatic Diseases 67.
- Ioan-Facsinay A, Willemze A, Robinson D, Peschken C, Markland J, Elias B, Menard H, Newkirk M, Fritzler M, Toes R, Huizinga T & El-Gabalawy H (2008), Marked differences in fine-specificity and isotype usage of the anti-citrulline response in health and disease, Annals of the Rheumatic Diseases 67.
- van Puijvelde GH, Habets KL, Litjens RE, van Duivenvoorde LM, van Wanrooij EJ, de Vos P, van der Marel GA, Overkleeft HS, Cohen-Tervaert JW, van Berkel TJ, Toes RE & Kuiper J (2008), Modulation of NKT cell activity reduces atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology 28(6).
- Wang J, van Dongen H, Scherer HU, Huizinga TWJ & Toes REM (2008), Suppressor activity among CD4+,CD25++ T cells is discriminated by membrane-bound tumor necrosis factor alpha, Arthritis and Rheumatism 58(6).
- van der Helm-van Mil AHM, Huizinga TWJ, de Vries RRP & Toes REM (2008), Tic-tac-toe does not provide lessons for appreciating the HLA-rheumatoid arthritis relationship: comment on the editorial by Bridges et al, Arthritis and Rheumatism 58(11).
- Visser K, Verpoort KN, van Dongen H, van der Kooij SM, Allaart CF, Toes REM, Huizinga TWJ & Mil AHMVDHV (2008), Pretreatment serum levels of anti-cyclic citrullinated peptide antibodies are associated with the response to methotrexate in recent-onset arthritis, Annals of the Rheumatic Diseases 67(8).
- van Oosterhout M, Bajema I, Levarht EWN, Toes REM, Huizinga TWJ & van Laar JM (2008), Differences in synovial tissue infiltrates between anti-cyclic citrullinated peptide-positive rheumatoid arthritis and anti-cyclic citrullinated peptide-negative rheumatoid arthritis, Arthritis and Rheumatism 58(1).
- van Mierlo GJD, Scherer HU, Hameetman M, Morgan ME, Flierman R, Huizinga TWJ & Toes REM (2008), Cutting edge: TNFR-Shedding by CD4(+)CD25(+) regulatory T cells inhibits the induction of inflammatory mediators, Journal of Immunology 180(5).
- Willemze A, Ioan-Facsinay A, Robinson D, Peschken C, Markland J, Fritzler M, Newkirk M, Menard H, Elias B, Toes R, Huizinga T & El-Gabalawy H (2008), Isotype usage and fine specificity of anti-citrullunated protein antibodies and rheumatoid factor in first nations RA patients and their first degree relatives: New insights into RA onset, Journal of Rheumatology 35(6).
- Heemstra KA, Toes RE, Sepers J, Pereira AM, Corssmit EP, Huizinga TWJ, Romijn JA & Smit JW (2008), Rituximab in relapsing Graves' disease, a phase II study, European Journal of Endocrinology 159(5).
- Salazar L, Aravena O, Abello P, Escobar A, Contreras-Levicoy J, Rojas-Colonelli N, Catalan D, Aguirre A, Zuniga R, Pesce B, Gonzalez C, Cepeda R, Cuchacovich M, Molina MC, Salazar-Onfray F, Delgado M, Toes RE & Aguillon JC (2008), Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cells, Annals of the Rheumatic Diseases 67(9).
- Houwing-Duistermaat JJ, van der Woude D, Toes REM, Huizinga TWJ, van der Helm-van Mil AHM & de Vries RRP (2008), Estimation of the heritability and the contribution of known genetic factors from twin data applied to Rheumatoid Arthritis, Genetic Epidemiology 32(7).
- Feitsma AL, van der Helm-van Mil AHM, Huizinga TWJ, de Vries RRP & Toes REM (2008), Protection against rheumatoid arthritis by HLA: nature and nurture, Annals of the Rheumatic Diseases 67.
- Wang J & Toes REM (2008), Mechanisms of oral tolerance revisited, Arthritis Research and Therapy 10(2).
- van der Helm-van Mil AHM, van der Kooij SM, Allaart CF, Toes REM & Huizinga TWJ (2008), A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis, Annals of the Rheumatic Diseases 67(6).
- de Vries-Bouwstra JK, Goekoop-Ruiterman YPM, Verpoort KN, Schreuder GMT, Ewals JAPM, Terwiel JP, Ronday HK, Kerstens PJSM, Toes REM, de Vries RRP, Breedveld FC, Dijkmans BAC, Huizinga TWJ & Allaart CF (2008), Progression of joint damage in early rheumatoid arthritis, Arthritis and Rheumatism 58(5).
- Chang M, Saiki RK, Cantanese JJ, Lew D, van der Helm-van Mil AHM, Toes REM, Huizinga TWJ, Ardlie KG, Criswell LA, Seldin MF, Amos CI, Kastner DL, Gregersen PK, Schrodi SJ & Begovich AB (2008), The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis, Arthritis and Rheumatism 58(6).
- Steenvoorden MMC, Toes REM, Ronday HK, Huizinga TWJ & DeGroot J (2007), RAGE activation induces invasiveness of RA fibroblast-like synoviocytes in vitro, Clinical and Experimental Rheumatology 25(5).
- Verpoort KN, Cheung K, Ioan-Facsinay A, van der Helm-van Mil AHM, de Vries-Bouwstra JK, Allaart CF, Drijfhout JW, de Vries RRP, Breedveld FC, Huizinga TWJ, Pruijn GJM & Toes REM (2007), Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles, Arthritis and Rheumatism 56(12).
- van Dongen H, van Aken J, Lard LR, Visser K, Ronday HK, Hulsmans HMJ, Speyer I, Westedt ML, Peeters AJ, Allaart CF, Toes REM, Breedveld FC & Huizinga TWJ (2007), Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis - A double-blind, randomized, placebo-controlled trial, Arthritis and Rheumatism 56(5).
- van Weel V, Seghers L, Toes R, van Bockel H & Quax P (2007), Natural killer and CD4+T lymphocytes play a dominant role in collateral artery development, Inflammation Research 56.
- Kurreeman FAS, Verpoort KN, Ioan-Facsinay A, Schonkeren JJM, Uh HW, Slagboom E, Westendorp RG, Toes REM & Huizinga TWJ (2007), The association between IL10 and joint destruction in RA can be attributed to enhanced autoantibody responses, Annals of the Rheumatic Diseases 66.
- Verpoort KN, Voort EAMP, Mil AHMV, Zijde CMJ, van Tol MJD, Drijfhout JW, Breedveld FC, de Vries RRP, Huizinga TWJ & Toes REM (2007), Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles, Arthritis and Rheumatism 56(9).
- Teng, Y.; Levarht, N.; Bajema, I.; Toes, R.; Huizinga, T. & Laar, J. van (2007), Recruitment of B lymphocytes into the periphery is associated with disease activity in patients with refractory rheumatoid arthritis, Annals of the Rheumatic Diseases 66.
- Teng, Y.; Hashemi, M.; Levarht, N.; Bajema, I.; Toes, R.; Huizinga, T. & Laar, J. van (2007), Depleting effects of anti-CD20 monoclonal antibodies in blood, bone marrow and synovium of patients with refractory rheumatoid arhtritis, Annals of the Rheumatic Diseases 66.
- Steenvoorden MMC, Bank RA, Ronday HK, Toes REM, Huizinga TWJ & DeGroot J (2007), Fibroblast-like synoviocyte-chondrocyte interaction in cartilage degradation, Clinical and Experimental Rheumatology 25(2).
- van Oosterhout M, Bajema IM, Levarht NWN, Toes REM, Huizinga TJ & van Laar JM (2007), Synovial differences between anti-CCP positive, Annals of the Rheumatic Diseases 66.
- Feitsma A, Worthington J, van der Helm-van Mil AHM, Plant D, van der Horst-Bruinsma IE, Hulzinga TWH, Toes REM & de Vries RRP (2007), Protective effect on rheumatoid arthritis of non-inherited maternal HLA-DR antigens, Annals of the Rheumatic Diseases 66.
- van der Helm - van Mil AHM, Verpoort KN, Pruijn GJM, de Vries RRP, Allaart C, Huizinga TWJ & Toes REM (2007), The HLA-DBR1 shared epitope allieles influence both the magnitude and specificity of the ACPA-response in ACPA-positive rheumatoid arthritis patients, Annals of the Rheumatic Diseases 66.
- Kurreeman FAS, Verpoort KN, Ioan-Facsinay A, Schonkeren JJM, Uh H, Slagboom E, Westendorp R, Toes REM & Huizinga TWJ (2007), The association between IL10 and joint destruction in RA can be attributed to enhanced autoantibody responses, Annals of the Rheumatic Diseases 66.
- Verpoort KN, Cheung K, Ioan-Facsinay A, Mil AVHV, de Vries R, Breedveld FC, Huizinga TWJ, Pruijn GJM & Toes REM (2007), Fine-specificity of the antibodies against citrullinated protein response is influenced by shared epitope alleles, Arthritis Research and Therapy 9.
- van der Helm-van Mil AH, Kurreeman FA, Toes RE & Huizinga TW (2007), Association of tumor necrosis factor alpha polymorphism and radiographic progression in rheumatoid arthritis: comment on the article by Khanna et al, Arthritis and Rheumatism 56(3).
- Feitsma AL, Worthington J, Mil AHMVDHV, Plant D, Thomson W, Ursum J, van Schaardenburg D, van der Horst-Bruinsma IE, van Rood IJ, Huizinga TWJ, Toes REM & de Vries RRP (2007), Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development, Proceedings of the National Academy of Sciences 104(50).
- Huizinga T, van der Helm-van Mil A, Verpoort KN, Kurreeman F, Thabet M, Schonkeren J & Toes REM (2007), Progress in understanding the pathogenesis of RA by identifying genetic risk factors, Inflammation Research 56.
- Wang J, Scherer HU, Van Dongen H, Huizinga TW & Toes REM (2007), Membrane-bound TNF discriminates suppressor activity among CD4+CD25++ T cells, Zeitschrift f�r Rheumatologie 66.
- Teng YKO, Verburg RJ, Verpoort KN, Diepenhorst GMP, Bajema IM, Tol MJD, Jol-van der zijde ECM, Toes REM, Huizinga TW & van Laar JM (2007), Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study, Arthritis Research and Therapy 9(5).
- Kurreeman FAS, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, Stoeken-Rijsbergen G, van der Helm-van Mil AHM, Allaart CF, Verduyn W, Houwing-Duistermaat J, Alfredsson L, Begovich AB, Klareskog L, Huizinga TWJ & Toes REM (2007), A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis, PLoS Medicine 4(9).
- van Weel V, Toes REM, Seghers L, Deckers MML, de Vries MR, Eilers PH, Sipkens J, Schepers A, Eefting D, van Hinsbergh VWM, van Bockel JH & Quax PHA (2007), Natural killer cells and CD4(+) T-Cells modulate collateral artery development, Arteriosclerosis, Thrombosis, and Vascular Biology 27(11).
- Teng, Y.K.O.; Levarht, E.W.N.; Hashemi, M.; Bajema, I.M.; Toes, R.E.A.; Huizinga, T.W.J. & Laar, J.M. van (2007), Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment, Arthritis and Rheumatism 56(12).
- Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, van der Helm-van Mil AHM, Toes REM, Huizinga TW, Klareskog L & Alfredsson L (2007), Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis, American Journal of Human Genetics 80(5).
- van Duivenvoorde LM, Han WGH, Bakker AM, Louis-Plence P, Charbonnier LM, Apparailly F, van der Voort EIH, Jorgensen C, Huizinga TWJ & Toes REM (2007), Immunomodulatory dendritic cells inhibit Th1 responses and arthritis via different mechanisms, Journal of Immunology 179(3).
- Filerman R, Westerhuis G, Hameetman M, van Dulvenvoorde LM, van Hall T, van Lear JM, Fibbe WE & Toes REM (2007), Targeting host B-cell immune responses by persistent donor NK-cell alloreactivity following nonmyeloablative allogeneic stem cell transplantation, Blood 109(12).
- van der Helm-van Mil AHM, Huizinga TWJ, de Vries RRP & Toes REM (2007), Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritis, Arthritis and Rheumatism 56(6).
- van der Helm-van Mil AHM, Verpoort KN, le Cessie S, Huizinga TWJ, de Vries RRP & Toes REM (2007), The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide, Arthritis and Rheumatism 56(2).
- van der Helm-van Mil AHM, le Cessie S, van Dongen H, Breedveld FC, Toes REM & Huizinga TWJ (2007), A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis - How to guide individual treatment decisions, Arthritis and Rheumatism 56(2).
- Wang J, Ioan-Facsinay A, Van der Voort EIH, Huizinga TWJ & Toes REM (2007), Transient expression of FOXP3 in human activated nonregulatory CD4(+) T cells, European Journal of Immunology 37(1).
- Montfoort, N. van; Jong, J.M.H. de; Schuurhuis, D.H.; Voort, E.I.H. van der; Camps, M.G.M.; Huizinga, T.W.J.; Kooten, C. van; Daha, M.R.; Verbeek, J.S.; Ossendorp, F. & Toes, R.E.M. (2007), A novel role of complement factor C1q in augmenting the presentation of antigen captured in immune complexes to CD8+T lymphocytes, Journal of Immunology 178(12).
- Feitsma AL, Toes REM, Begovich AB, Chokkalingam AP, de Vries RRP, Huizinga TWJ & van der Helm-van Mil AHM (2007), Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients, Rheumatology 46(7).
- van der Helm-van Mil AHM, Verpoort KN, Pruijn GJM, de Vries RRP, Allaart C, Huizinga TWJ & Toes REM (2007), The HLA-DBR1 shared epitope alleles influence both the magnitude and specificity of the ACPA-response in ACPA-positive rheumatoid arthritis patients, Annals of the Rheumatic Diseases 66.
- van Dongen H, van Aken J, Lard LR, Visser K, Ronday HK, Hulsmans HMJ, Speyer I, Westedt ML, Peeters AJ, Allaart CF, Toes REM, Breedveld FC & Huizinga TWJ (2007), The probable rheumatoid arthritis: Methotrexate versus placebo treatment (the prompt) study: A double-blind randomized controlled trial, Annals of the Rheumatic Diseases 66.
- Teng YKO, Hashemi M, Levahrt NL, Toes REM, Huizinga TWJ & van Laar JM (2007), Recruitment of B lymphocytes into the periphery is associated with disease activity in patients with refractory rheumatoid arthritis, Annals of the Rheumatic Diseases 66.
- Feitsma AL, Worthington J, van der Helm-van Mil AHM, Plant D, van der Horst-Bruinsma IE, Huizinga TWJ, Toes REM & de Vries RRP (2007), Protective effect on rheumatoid arthritis of non-inherited maternal HLA-DR antigens, Annals of the Rheumatic Diseases 66.
- Wang J, van Dongen H, Scherer HU, Huizinga TWJ & Toes REM (2007), Suppressor activity among CD4+CD25++ T cells is discriminated by membrane-bound TNF, Annals of the Rheumatic Diseases 66.
- Thabet MM, Wesoly J, Slagboom PE, Toes REM & Huizinga TWJ (2007), FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians, Annals of the Rheumatic Diseases 66(6).
- Wang J, Ioan-Facsinay A, Scherer HU, van der Voort EIH, Huizinga TWJ & Toes REM (2007), Transient expression of FOXP3 in human activated nonregulatory CD4+T cells, Annals of the Rheumatic Diseases 66.
- van der Helm-van Mil AHM, Verpoort KN, Huizinga TWJ, de Vries RRP & Toes REM (2007), Refinement of the contribution of smoking to the ACPA response, Annals of the Rheumatic Diseases 66.
- Charbonnier LM, Apparailly F, Han W, Van Duivenvoorde LM, Toes REM, Jorgensen C & Plence PL (2007), CD49B+ regulatory T cells are able to cure arthritis, Annals of the Rheumatic Diseases 66.
- van Duivenvoorde L, Han W, Bakker A, Louis-Plence P, Charbonnier LM, Apparailly F, van der Voort E, Jorgenson C, Huizinga T & Toes R (2007), Protection against collagen-induced arthritis with differentially modulated dendritic cells, Annals of the Rheumatic Diseases 66.
- Wesoly J, Hu X, Thabet MM, Chang M, Uh H, Allaart CF, Toes REM, Houwing-Duistermaat JJ, Begovich AB & Huizinga TWJ (2007), The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population, Rheumatology 46(4).
- Sigurdsson S, Padyukov L, Kurreeman FAS, Liljedahl U, Wiman AC, Alfredsson L, Toes R, Ronnelid J, Klareskog L, Huizinga TWJ, Alm G, Syvanen AC & Ronnblom L (2007), Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis, Arthritis and Rheumatism 56(7).
- Kuiper J, Halbets KLL, van Puijvelde GHM, van Wanrooij EJA, Toes RE & van Berkel TJC (2007), OxLDL-pulsed dendritic cells: An immunotherapy in atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology 27(6).
- Remans PHJ, Wijbrandts CA, Sanders ME, Toes RE, Breedveld FC, Tak PP, van Laar JM & Reedquist KA (2006), CTLA-4Ig suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPase mediator of oxidative stress in rheumatoid arthritis T cells, Arthritis and Rheumatism 54(10).
- de Vries RRP, Huizinga TWJ & Toes REM (2006), HLA and RA revisited: Citrullinated food for the SE hypothesis, the DR6 effect, and NIMA, Human Immunology 67(6).
- Flierman R, Westerhuis G, Fibbe W, Van Laar J & Toes R (2006), Alloreactive NK cells in the control of systemic autoimmune disease after allogeneic bone marrow transplantation, Annals of the Rheumatic Diseases 65.
- Steenvoorden MMC, Huizinga TWJ, Verzijl N, Bank RA, Ronday HK, Luning HAF, Lafeber FPJG, Toes REM & DeGroot J (2006), Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes, Arthritis and Rheumatism 54(1).
- de Jong JMH, Schuurhuis DH, Ioan-Facsinay A, van der Voort EIH, Huizinga TWJ, Ossendorp F, Toes REM & Verbeek JS (2006), Murine Fc receptors for IgG are redundant in facilitating presentation of immune complex derived antigen to CD8(+) T cells in vivo, Molecular Immunology 43(13).
- Steenvoorden MMC, Tolboom TCA, van der Pluijm G, Lowik C, Visser CPJ, DeGroot J, Gittenberger-DeGroot AC, DeRuiter MC, Wisse BJ, Huizinga TWJ & Toes REM (2006), Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics, Arthritis Research and Therapy 8(6).
- Steenvoorden MMC, van der Helm-van Mil AHM, Stoeken G, Bank RA, DeVries RRP, Huizinga TWJ, DeGroot J & Toes REM (2006), The RAGE G82S polymorphism is not associated with rheumatoid arthritis independently of HLA-DRB1*0401, Rheumatology 45(4).
- Tolboom TCA, Zhang YH, Henriquez NV, Nelissen RGHH, Toes REM, Noteborn MHM & Huizinga TWJ (2006), Fibroblast-like synoviocytes from patients with rheumatoid arthritis are more sensitive to apoptosis induced by the viral protein, apoptin, than fibroblast-like synoviocytes from trauma patients, Clinical and Experimental Rheumatology 24(2).
- Linn-Rasker SP, van der Helm-van Mil AHM, van Gaalen FA, Kloppenburg M, de Vries RRP, le Cessie S, Breedveld FC, Toes REM & Huizinga TWJ (2006), Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles, Annals of the Rheumatic Diseases 65(3).
- de Jong JMH, Schuurhuis DH, Ioan-Facsinay A, Welling MM, Camps MGM, van der Voort EIH, Huizinga TWJ, Ossendorp F, Verbeek JS & Toes REM (2006), Dendritic cells, but not macrophages or B cells, activate major histocompatibility complex class II-restricted CD4(+) T cells upon immune-complex uptake in vivo, Immunology 119(4).
- van der Helm-van Mil AHM, Verpoort KN, Breedveld FC, Huizinga TWJ, Toes REM & de Vries RRP (2006), The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis, Arthritis and Rheumatism 54(4).
- Boonman ZFHM, Schurmans LRHM, van Rooijen N, Melief CJM, Toes REM & Jager MJ (2006), Macrophages are vital in spontaneous intraocular tumor eradication, Investigative Ophthalmology & Visual Science 47(7).
- Ossevoort M, Zaldumbide A, Cramer SJ, van der Voort EIH, Toes REM & Hoeben RC (2006), Characterization of an immuno 'stealth' derivative of the herpes simplex virus thymidine-kinase gene, Cancer Gene Therapy 13(6).
- Verpoort KN, Jol-van der Zijde CM, Papendrecht-van der Voort EAM, Ioan-Facsinay A, Drijfhout JW, van Tol MJD, Breedveld FC, Huizinga TWJ & Toes REM (2006), Isotype distribution of anti-cyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response, Arthritis and Rheumatism 54(12).
- Charbonnier LM, van Duivenvoorde LM, Apparailly F, Cantos C, Han WGH, Noel D, Duperray C, Huizinga TWJ, Toes REM, Jorgensen C & Louis-Plence P (2006), Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b(+) regulatory T cells, Journal of Immunology 177(6).
- Veltrop-Duits, L.A.; Heemskerk, B.; Sombroek, C.C.; Vreeswijk, T. van; Gubbels, S.; Toes, R.E.M.; Melief, C.J.M.; Franken, K.L.M.C.; Havenga, M.; Tol, M.J.D. van & Schilham, M.W. (2006), Human CD4(+) T cells stimulated by conserved adenovirus 5 hexon peptides recognize cells infected with different species of human adenovirus, European Journal of Immunology 36(9).
- Verpoort K, Van der Helm-Van Mil AHM, de Vries RRP, Huizinga TWJ & Toes REM (2006), The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-citrullinated protein antibodies and not for the development of rheumatoid arthritis, Annals of the Rheumatic Diseases 65: A39-A39.
- Heemskerk, B.; Vreeswijk, T. van; Veltrop-Duits, L.A.; Sombroek, C.C.; Franken, K.; Verhoosel, R.M.; Hiemstra, P.S.; Leeuwen, D. van; Ressing, M.E.; Toes, R.E.M.; Tol, M.J.D. van & Schilham, M.W. (2006), Adenovirus-specific CD4(+) T cell clones recognizing endogenous antigen inhibit viral replication in vitro through cognate interaction, Journal of Immunology 177(12).
- Van der Helm-van Mil AHM, Verpoort KN, Breedveld FC, Huizinga TWJ, Toes REM & De Vries RRP (2006), The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-CCP antibodies and are not an independent risk factor to develop rheumatoid arthritis, Annals of the Rheumatic Diseases 65: 74-74.
- De Vries-Bouwstra JK, Goekoop-Ruiterman YPM, Verpoort KN, Schreuder GMT, De Bois MHW, Mallee C, Toes REM, De Vries RRP, Breedveld FC, Dijkmans BAC, Huizinga TWJ & Allaart CF (2006), The association of HLA class II antigens and anti-CCP antibodies with progression of joint damage is affected by early and targeted treatment of rheumatoid arthritis, Annals of the Rheumatic Diseases 65: 88-89.
- van Duivenvoorde LM, Bakker AM, van Mierlo GJD, Huizinga TWJ & Toes REM (2006), Protection against collagen induced arthritis with differentially modulated dendritic cells, Annals of the Rheumatic Diseases 65: A10-A10.
- Teng, Y.K.O.; Verburg, R.J.; Verpoort, K.N.; Zijde, E.C.J.J.V.D.; Huizinga, T.W.J.; Toes, R.E.M.; Breedveld, F.C. & Laar, J.M. van (2006), Proliferating short-lived antibody secreting cells in patients with rheumatoid arthritis are mainly responsible for autoantibody production, Annals of the Rheumatic Diseases 65: 101-102.
- Van Dongen H, Van Aken J, Lard LR, Ronday HK, Speyer I, Westedt ML, Allaart CF, Toes REM, Breedveld FC & Huizinga TWJ (2006), Probable rheumatoid arthritis methotrexate versus placebo therapy (PROMPT)-study: Indications for a window of opportunity in the treatment of patients with undifferentiated arthritis, Annals of the Rheumatic Diseases 65: 54-54.
- van Duivenvoorde LM, van Mierlo GJD, Boonman ZFHM & Toes REM (2006), Dendritic cells: Vehicles for tolerance induction and prevention of autoimmune diseases, Immunobiology 211(6-8).
- Verpoort, K.N.; Jol-van Der Zijde, C.M.; Papendrecht-van der Voort, E.A.M.; Ioan-Facsinay, A.; Drijfhout, J.W.; Tol, M.J.D. van; Breedveld, F.C.; Huizinga, T.W.J. & Toes, R.E.M. (2006), Isotypes of anti-citrullinated peptide antibodies (ACPA) in undifferentiated arthritis and rheumatoid arthritis suggest an ongoing immune response, Annals of the Rheumatic Diseases 65: 102-102.
- Huizinga T, Verpoort KN, Van der Helm-van Mil AH, Toes REM, Mckay J, Weiser S, Zhong J & Freimuth W (2006), Distinct genetic and environmental risk factors, distinct disease outcome and distinct responses to anti-B cell therapy (lymphostat-B) indicate that anti-CCP-positive RA is a distinct disease entity, Annals of the Rheumatic Diseases 65: 59-59.
- Wesoly J, Dillingh MR, De Vries RRP, Toes REM & Huizinga TWJ (2006), DEK gene and susceptibility to rheumatoid arthitis, Annals of the Rheumatic Diseases 65: A40-A40.
- Huizinga TWJ, Amos CI, van der Helm-van Mil AHM, Chen W, van Gaalen FA, Jawaheer D, Schreuder GMT, Wener M, Breedveld FC, Ahmad N, Lum RF, de Vries RRP, Gregersen PK, Toes REM & Criswell LA (2005), Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins, Arthritis and Rheumatism 52(11).
- Wesoly J, Toes REM, Slagboom PE & Huizinga TWJ (2005), RUNX1 intronic SNP is not associated with rheumatoid arthritis susceptibility in Dutch Caucasians, Rheumatology 44(9).
- Flierman R, Witteveen HJ, van der Voort EIH, Huizinga TWJ, de Vries RRP, Fibbe WE, Toes REM & van Laar JM (2005), Control of systemic B cell-mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex-mismatched allogeneic bone marrow transplantation, Blood 105(7).
- Verburg RJ, Flierman R, Sont JK, Ponchel F, van Dreunen L, Levarht EW, Welling MM, Toes REM, Isaacs JD & van Laar JM (2005), Outcome of intensive immunosuppression and autologous stem cell transplantation in patients with severe rheumatoid arthritis is associated with the composition of synovial T cell infiltration, Annals of the Rheumatic Diseases 64(10).
- Verpoort KN, van Gaalen FA, van der Helm-van Mil AHM, Schreuder GMT, Breedveld FC, Huizinga TWJ, de Vries RRP & Toes REM (2005), Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis, Arthritis and Rheumatism 52(10).
- Westerhuis G, Maas WGE, Willemze R, Toes REM & Fibbe WE (2005), Long-term mixed chimerism after immunologic conditioning and MHC-mismatched stem-cell transplantation is dependent on NK-cell tolerance, Blood 106(6).
- Westerhuis G, Maas WE, Willemze R, Toes REM & Fibbe W (2005), NK-cell tolerance in major mismatched stem cell transplantation, Bone Marrow Transplantation 35.
- van Oosterhout M, Levarht EWN, Sont JK, Huizinga TWJ, Toes REM & van Laar JM (2005), Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNF alpha and IL18 but not CXCL12, Annals of the Rheumatic Diseases 64(4).
- Dumortier H, van Mierlo GJD, Egan D, van Ewijk W, Toes REM, Offringa R & Melief CJM (2005), Antigen presentation by an immature myeloid dendritic cell line does not cause CTL deletion in vivo, but generates CD8(+) central memory-like T cells that can be rescued for full effector function, Journal of Immunology 175(2).
- van Gaalen F, Ioan-Facsinay A, Huizinga TWJ & Toes REM (2005), The devil in the details: The emerging role of anticitrulline autoimmunity in rheumatoid arthritis, Journal of Immunology 175(9).
- van der Helm-van Mil AHM, Verpoort KN, Breedveld FC, Toes REM & Huizinga TWJ (2005), Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis, Arthritis Research and Therapy 7(5).
- Boonman ZFHM, van Mierlo GJD, Fransen MF, de Keizer RJW, Jager MJ, Melief CJM & Toes REM (2005), Maintenance of immune tolerance depends on normal tissue homeostasis, Journal of Immunology 175(7).
- Verpoort KN, van Gaalen FA, van der Helm-van Mil A, Schreuder GMT, Breedveld FC, Huizinga TWJ, de Vries RRP & Toes REM (2005), Hla-dr3 is associated with anti-ccp antibody negative rheumatoid arthritis., Arthritis and Rheumatism 52(9): S150-S150.
- Kurreeman FAS, De Vries J, Westendorp R, Van Den Biggelaar AH, SChonkeren JJM, Toes REM & Huzinga TWJ (2005), Role of IL-10 as a susceptibility factor for rheumatoid arthritis and cardiovascular disease, Arthritis Research and Therapy 7: S41-S41.
- Verpoort KN, van Gaalen FA, Helm-Van Mil AHMVD, Schreuder GMT, de Vries RRP, Breedveld FC, Huizinga TWJ & Toes REM (2005), HLA DR3 is associated with anti-CCP negative rheumatoid arthritis, Annals of the Rheumatic Diseases 64: 120-120.
- Morgan ME, van Bilsen JHM, Bakker AM, Heemskerk B, Schilham MW, Hartgers FC, Elferink BG, van der Zanden L, de Vries RRP, Huizinga TWJ, Ottenhoff THM & Toes REM (2005), Expression of FOXP3 mRNA is not confined to CD4(+)CD25(+) T regulatory cells in humans, Human Immunology 66(1).
- den Boer AT, van Mierlo GJD, Fransen MF, Melief CJM, Offringa R & Toes REM (2005), CD4(+) T cells are able to promote tumor growth through inhibition of tumor-specific CD8(+) T-cell responses in tumor-bearing hosts, Cancer Research 65(15).
- van der Helm-van Mil AHM, Huizinga TWJ, Schreuder GMT, Breedveld FC, de Vries RRP & Toes REM (2005), An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility, Arthritis and Rheumatism 52(9).
- de Jong JMH, Schuurhuis DH, Ioan-Facsinay A, van der Voort EIH, Huzinga TJW, Ossendorp F, Verbeek JS & Toes REM (2005), Fc gamma R-mediated uptake and processing of antigen-immunoglobulin complexes by professional antigen-presenting cells, Arthritis Research and Therapy 7.
- Wesoly J, van der Helm-van Mil AHM, Toes RE, Chokkalingam AP, Carlton VEH, Begovich AB & Huizinga TWJ (2005), Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort, Arthritis and Rheumatism 52(9).
- Morgan ME, Flierman R, van Duivenvoorde LM, Witteveen HJ, van Ewijk W, van Laar JA, de Vries RRP & Toes REM (2005), Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells, Arthritis and Rheumatism 52(7).
- Tolboom TCA, Mil AHMVDV, Nelissen RGHH, Breedveld FC, Toes REM & Huizinga TWJ (2005), Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis, Arthritis and Rheumatism 52(7).
- de Jong JMH, Schuurhuis DH, Ioan A, Van der Voort EIH, Huizinga TWJ, Ossendorp F, Verbeek JS & Toes REM (2005), Fc gamma R-mediated uptake and processing of antigen-immunoglobulin complexes by professional antigen presenting cells., Arthritis and Rheumatism 52(9).
- Flierman R, Witteveen H, Van Der Voort E, Huizinga T, De Vries R, Fibbe W, Toes R & Van Laar J (2005), Control of systemic B cell-mediated autoimmune disease by nonmyeloablative conditioning and MHC-mismatched allogeneic bone marrow transplantation, Annals of the Rheumatic Diseases 64.
- Fournel S, Wieckowski S, Sun WM, Trouche N, Dumortier H, Bianco A, Chaloin O, Habib M, Peter JC, Schneider P, Vray B, Toes RE, Offringa R, Melief CJM, Hoebeke J & Guichard G (2005), C-3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L, Nature Chemical Biology 1(7).
- Kurreeman FAS, Schonkeren JJM, Heijmans BT, Toes REM & Huizinga TWJ (2004), Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level, Human Molecular Genetics 13(16).
- Flierman R, Morgan L, van Dulvenvoorde L, de Vries RRP, Fibbe WE, Huizinga TJW, Toes REM & van Laar JM (2004), Allogeneic bone marrow transplantation can suppress established and otherwise chronic collagen-induced arthritis after a nonmyeloablative conditioning regimen employing anti-CD40 ligand monoclonal antibody, Arthritis Research and Therapy 6.
- van Gaalen FA, Toes REM, Ditzel HJ, Schaller M, Breedveld FC, Verweij CL & Huizinga TWJ (2004), Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis, Arthritis and Rheumatism 50(2): 395-399.
- van Bilsen JHM, van Dongen H, Lard LR, van der Voort EIH, Elferink DG, Bakker AM, Miltenburg AMM, Huizinga TWJ, de Vries RRP & Toes REM (2004), Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis, Proceedings of the National Academy of Sciences 101(49).
- Lard LR, Roep BO, Toes REM & Huizinga TWJ (2004), Enhanced concentrations of interleukin 16 are associated with joint destruction in patients with rheumatoid arthritis, Journal of Rheumatology 31(1).
- Morgan ME, Witteveen HJ, Sutmuller RPM, de Vries RRP & Toes REM (2004), CD25(+) regulatory cells from HLA-DQ8 transgenic mice are capable of modulating collagen-induced arthritis, Human Immunology 65(11).
- Westerhuis G, Maas WG, Willemze R, Toes RE & Fibbe WE (2004), Hematopoietic chimerism following non-myeoloablative stem cell transplantation is dependent on NK cell tolerance., Blood 104(11).
- Boonman, Z.F.H.M.; Mierlo, G.J.D. van; Fransen, M.F.; Franken, K.L.M.C.; Offringa, R.; Melief, C.J.M.; Jager, M.J. & Toes, R.E.M. (2004), Intraocular tumor antigen drains specifically to submandibular lymph nodes, resulting in an abortive cytotoxic T cell reaction, Journal of Immunology 172(3).
- Mierlo, G.J.D. van; Boonman, Z.F.H.M.; Dumortier, H.M.H.; Boer, A.T. den; Fransen, M.F.; Nouta, J.; Voort, E.I.H. van der; Offringa, R.; Toes, R.E.M. & Melief, C.J.M. (2004), Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8(+) CTL to cause tumor eradication, The Journal of Immunology 173(11).
- van Gaalen FA, Linn-Rasker SP, van Venrooij WJ, de Jong BA, Breedveld FC, Verweij CL, Toes REM & Huizinga TWJ (2004), Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis - A prospective cohort study, Arthritis and Rheumatism 50(3): 709-715.
- Hofmann M, Radsak M, Rechtsteiner G, Wiemann K, Gunder M, Bien-Grater U, Offringa R, Toes REM, Rammensee HG & Schild H (2004), T cell avidity determines the level of CTL activation, European Journal of Immunology 34(7).
- van Gaalen FA, van Aken J, Huizinga TW, Schreuder GM, Breedveld FC, Zanelli E, van Venrooij WJ, Verweij C, Toes RE & de Vries R (2004), Association between Hla class Ii genes and autoantibodies to cyclic citrullinated peptides (Ccp) affects severity of rheumatoid arthritis., Arthritis and Rheumatism 50(9): S359-S359.
- Schagen FHE, Ossevoort M, Toes REM & Hoeben RC (2004), Immune responses against adenoviral vectors and their transgene products: a review of strategies for evasion, Critical Reviews in Oncology/Hematology 50(1).
- den Boer AT, van Mierlo GJD, Fransen MF, Melief CJM, Offringa R & Toes REM (2004), The tumoricidal activity of memory CD8(+) T cells is hampered by persistent systemic antigen, but full functional capacity is regained in an antigen-free environment, Journal of Immunology 172(10).
- van Gaalen FA, van Aken J, Huizinga TWJ, Schreuder GMT, Breedveld FC, Zanelli E, van Venrooij WJ, Verweij CL, Toes REM & de Vries RRP (2004), Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis, Arthritis and Rheumatism 50(7).
- Flierman R, Witteveen H, van der Voort E, Huizinga T, de Vries R, Fibbe W, Toes R & van Laar J (2004), Effective treatment of collagen-induced arthritis with nonmyeloablative conditioning and MHC-mismatched allogeneic bone marrow transplantation., Arthritis and Rheumatism 50(9).
- Flierman R, Morgan ME, Van Duivenvoorde LM, De Vries RRP, Fibbe WE, Toes REM & Van Laar JM (2004), Nonmyeloablative conditioning with anti-CD40L monoclonal antibody and low-dose total body irradiation followed by allogeneic bone marrow transplantation is effective as treatment for collagen-induced arthritis, Annals of the Rheumatic Diseases 63.
- Huizinga T, Schonkeren J, Kurreeman F, van Gaalen F, Westendorp R, Breedveld FC & Toes R (2003), Analysis of IL-10 gene variants in rheumatoid arthritis, Arthritis Research and Therapy 5: S25-S25.
- Offringa R, de Jong A, Toes REM, van der Burg SH & Melief CJM (2003), Interplay between human papillomaviruses and dendritic cells, Current Topics in Microbiology and Immunology 276.
- Lard LR, van Gaalen FA, Schonkeren JJM, Pieterman EJ, Stoeken G, Vos K, Nelissen RGHH, Westendorp RGJ, Hoeben RC, Breedveld FC, Toes REM & Huizinga TWJ (2003), Association of the-2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis, Arthritis and Rheumatism 48(7).
- van Gaalen FA, Lard L, Schonkeren J, Pieterman E, Stoeken G, Vos K, Nelissen R, Westendorp R, Hoeben R, Breedveld FC, Toes R & Huizinga TWJ (2003), A polymorphism in the IL-10 promoter affects autoantibody production and subsequent joint destruction in rheumatoid arthritis, Arthritis Research and Therapy 5: S18-S19.
- Boonman Z, Wang S, Schurmans LRHM, Melief CJM, Niederkorn JY, Toes REM & Jager MJ (2003), CD4+ T cells, IFN gamma and macrophages play an important role in the spontaneous eradication of an intraocular tumor, Investigative Ophthalmology & Visual Science 44.
- Wang S, Boonman ZFH, Jager MJ, Toes REM, Li HC, He YG, Mayhew E & Niederkorn JY (2003), Role of interferon-gamma and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in the immune rejection of syngenic intraocular tumors, Investigative Ophthalmology & Visual Science 44.
- Wang SX, Boonman ZFHM, Li HC, He YG, Jager MJ, Toes REM & Niederkorn JY (2003), Role of TRAIL and IFN-gamma in CD4(+) T cell-dependent tumor rejection in the anterior chamber of the eye, Journal of Immunology 171(6).
- Ossevoort M, Visser BMJ, van den Wollenberg DJM, van der Voort EIH, Offringa R, Melief CJM, Toes REM & Hoeben RC (2003), Creation of immune 'stealth' genes for gene therapy through fusion with the Gly-Ala repeat of EBNA-1, Gene Therapy 10(24).
- van Gaalen FA, Linn-Rasker SP, van Venrooij WJ, de Jong BA, Breedveld FC, Verweij CL, Toes REM & Huizinga TWJ (2003), Autoantibodies predict progression to rheumatoid arthritis in undifferentiated arthritis: a prospective cohort study, Arthritis Research and Therapy 5: S9-S9.
- van Gaalen FA, Toes REM, Ditzel HJ, Schaller M, Verweij CL & Huizinga TWJ (2003), Autoantibodies to GPI are predominantly present in extra-articular complications of human rheumatoid arthritis, Arthritis Research and Therapy 5: S9-S9.
- Tolboom TCA, Medema JP, van Gaalen FA, Huizinga TJ & Toes REM (2003), Fibroblast-like synoviocytes from rheumatoid arthritis patients express less FLICE-inhibitory protein than fibroblast-like synoviocytes from trauma patients: comment on the article by Schedel et al, Arthritis and Rheumatism 48(3).
- Morgan ME, Sutmuller RPM, Witteveen HJ, van Duivenvoorde LM, Zanelli E, Melief CJM, Snijders A, Offringa R, de Vries RRP & Toes REM (2003), CD25+cell depletion hastens the onset of severe disease in collagen-induced arthritis, Arthritis and Rheumatism 48(5).
- Heemskerk B, Veltrop-Duits LA, van Vreeswijk T, ten Dam MM, Heidt S, Toes REM, van Tol MJD & Schilham MW (2003), Extensive cross-reactivity of CD4(+) adenovirus-specific T cells: Implications for immunotherapy and gene therapy, Journal of Virology 77(11).
- Tolboom TCA, Pieterman E, van der Laan WH, Toes REM, Huidekoper AL, Nelissen RGHH, Breedveld FC & Huizinga TWJ (2002), Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10, Annals of the Rheumatic Diseases 61(11).
- Schilham MW, Claas EC, van Zaane W, Heemskerk B, Vossen JM, Lankester AC, Toes RE, Echavarria M, Kroes AC & van Tol MJ (2002), High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation, Clinical Infectious Diseases 35(5).
- Melief CJM, van der Burg SH, Toes REM, Ossendorp F & Offringa R (2002), Effective therapeutic anticancer vaccines based on precision guiding of cytolytic T lymphocytes, Immunological Reviews 188.
- van Mierlo GJD, den Boer AT, Medema JP, van der Voort EIH, Fransen MF, Offringa R, Melief CJM & Toes REM (2002), CD40 stimulation leads to effective therapy of CD40(-)tumors through induction of strong systemic cytotoxic T lymphocyte immunity, Proceedings of the National Academy of Sciences 99(8).
- Diehl L, van Mierlo GJD, den Boer AT, van der Voort E, Fransen M, van Bostelen L, Krimpenfort P, Melief CJM, Mittler R, Toes REM & Offringa R (2002), In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulatory pathway, Journal of Immunology 168(8).
- van Gaalen FA, Pieterman J, Aten E, Nelissen RGH, Hoeben RC, Toes REM & Huizinga TWJ (2002), Invasive behavior of rheumatoid synoviocytes and IL-10 promoter polymorphisms., Arthritis and Rheumatism 46(9): S552-S552.
- Verburg RJ, Toes REM, Fibbe WE, Breedveld FC & van Laar JM (2002), High dose chemotherapy and autologous hematopoietic stem cell transplantation for rheumatoid arthritis: A review, Human Immunology 63(8).
- Ugolini S, Arpin C, Anfossi N, Walzer T, Cambiaggi A, Forster R, Lipp M, Toes REM, Melief CJ, Marvel J & Vivier E (2001), Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8(+) T cells, Nature Immunology 2(5).
- Ludewig B, McCoy K, Pericin M, Ochsenbein AF, Dumrese T, Odermatt B, Toes REM, Melief CJM, Hengartner H & Zinkernagel RM (2001), Rapid peptide turnover and inefficient presentation of exogenous antigen critically limit the activation of self-reactive CTL by dendritic cells, Journal of Immunology 166(6).
- Sutmuller RPM, van Dulvenvoorde LM, van Elsas A, Schumacher TNM, Wildenberg ME, Allison JP, Toes REM, Offringa R & Melief CJM (2001), Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses, Journal of Experimental Medicine 194(6).
- Schurmans LRHM, Diehl L, den Boer AT, Sutmuller RPM, Boonman ZFHM, Medema JP, van der Voort EIH, Laman J, Melief CJM, Jager MJ & Toes REM (2001), Rejection of intraocular tumors by CD4(+) T cells without induction of phthisis, Journal of Immunology 167(10).
- den Boer AT, Diehl L, van Mierlo GJD, van der Voort EIH, Fransen MF, Krimpenfort P, Melief CJM, Offringa R & Toes REM (2001), Longevity of antigen presentation and activation status of APC are decisive factors in the balance between CTL immunity versus tolerance, Journal of Immunology 167(5).
- Toes REM, Nussbaum AK, Degermann S, Schirle M, Emmerich NPN, Kraft M, Laplace C, Zwinderman A, Dick TP, Muller J, Schonfisch B, Schmid C, Fehling HJ, Stevanovic S, Rammensee HG & Schild H (2001), Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products, Journal of Experimental Medicine 194(1).
- Medema JP, Schuurhuis DH, Rea D, van Tongeren J, de Jong J, Bres SA, Laban S, Toes REM, Toebes M, Schumacher TNM, Bladergroen BA, Ossendorp F, Kummer JA, Melief CJM & Offringa R (2001), Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: Differential modulation by T helper type 1 and type 2 cells, Journal of Experimental Medicine 194(5).
- Ossendorp F, Toes REM, Offringa R, van der Burg SH & Melief CJM (2000), Importance of CD4(+) T helper cell responses in tumor immunity, Immunology Letters 74(1).
- Diehl L, Den Boer AT, van der Voort EIH, Melief CJM, Offringa R & Toes REM (2000), The role of CD40 in peripheral T cell tolerance and immunity, Journal of Molecular Medicine 78(7).
- Offringa R, van der Burg SH, Ossendorp F, Toes REM & Melief CJM (2000), Design and evaluation of antigen-specific vaccination strategies against cancer, Current Opinion in Immunology 12(5).
- Singh-Jasuja H, Scherer HU, Hilf N, Arnold-Schild D, Rammensee HG, Toes REM & Schild H (2000), The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor.
- Emmerich NPN, Nussbaum AK, Stevanovic S, Priemer M, Toes REM, Rammensee HG & Schild H (2000), The human 26 S and 20 S proteasomes generate overlapping but different sets of peptide fragments from a model protein substrate.
- Schuurhuis DH, Laban S, Toes REM, Ricciardi-Castagnoli P, Kleijmeer MJ, van der Voort EIH, Rea D, Offringa R, Geuze HJ, Melief CJM & Ossendorp F (2000), Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli.
- Sijts AJAM, Standera S, Toes REM, Ruppert T, Beekman NJCM, van Veelen PA, Ossendorp FA, Melief CJM & Kloetzel PM (2000), MHC class I antigen processing of an Adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells.
- Zanelli E & Toes REM (2000), A dual function for CD40 agonists.
- Melief CJM, Toes REM, Medema JP, Van der Burg SH, Ossendorp F & Offringa R (2000), Strategies for immunotherapy of cancer, Advances in Immunology 75.
- Sutmuller RPM, Schurmans LRHM, van Duivenvoorde LM, Tine JA, van der Voort EIH, Toes REM, Melief CJM, Jager MJ & Offringa R (2000), Adaptive T cell immunotherapy of human uveal melanoma targeting gp100, Journal of Immunology 165(12).
- Singh-Jasuja H, Toes REM, Spee P, Munz C, Hilf N, Schoenberger SP, Ricciardi-Castagnoli P, Neefjes J, Rammensee HG, Arnold-Schild D & Schild H (2000), Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis.
- Lid wetenschappelijk adviesraad
- Member of the Immunology Scientific Reflection Panel
- Member Senior fellowship selection panel
- Voorzitter Wetenschappelijke raad
- Lid commissie ZonMW open competitie
- Bestuurslid