Niki Antypa
Associate professor
- Name
- Dr. N. Antypa
- Telephone
- +31 71 527 6677
- nantypa@fsw.leidenuniv.nl
- ORCID iD
- 0000-0001-9343-8842
Niki Antypa is an Associate Professor at the unit of Clinical Psychology at the Institute of Psychology. In her research, Antypa focuses on the chronobiology of depression and suicide.
More information about Niki Antypa
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Niki Antypa is an Associate Professor at the unit of Clinical Psychology at the Institute of Psychology. In her research, Antypa focuses on the chronobiology of depression and suicide.
Research on biological clock and depression
Antypa is particularly interested in how the internal biological clock (chronotype) interacts with other psychological and environmental influences and subsequently influences people’s vulnerability to depression and suicide.
Depression is a complex disorder with multiple potential causes. Through understanding the role of the biological clock, Antypa hopes to provide insights into the factors that contribute to the development or maintenance of depressive states. She also investigates interventions (e.g. light therapy, e-health) that help promote a healthier functioning of the clock and improve sleep, in different populations including depressed patients, students, and other. Depending on the population studied, these interventions aim to prevent disease or improve treatment.
Short CV
Niki Antypa was born on the island of Chios, Greece. Between 2000-2004, she studied Psychology at the American College of Greece where she obtained the degree Bachelor of Arts in Psychology with High Distinction.
She then moved to the Netherlands to study Clinical Psychology and at the end of 2006 she obtained her MSc in Psychology (cum laude) from Leiden University. From 2007 until 2011, she worked at the department of Clinical Psychology as a PhD student and in June 2011 she obtained her PhD degree. Her dissertation focused on cognitive vulnerability to depression, including the influence of genetic, environmental and nutritional factors.
With a Rubicon Grant awarded by NWO. (Dutch Scientific Organization), she carried out post-doctoral research at the Institute of Psychiatry, at the University of Bologna, in Italy.
In 2022, Antypa became an Associate Professor at the unit of Clinical Psychology at Leiden University.
Teaching
- Supervision of bachelor and master theses
- Clinical Internship supervision
- Internal Practice Internship co-ordinator, instructor and supervisor Instructor of Master’s courses such as Basic Therapeutic Skills and Clinical Interviewing and Assessment
- Research internship supervisor
Basic Teaching Qualification (Basiskwalificatie Onderwijs; BKO) obtained: 6 October 2017.
Grants
- N.W.A. (Dutch Research Agenda) Grant BioClock Consortium (2020 – 2026)
Project PI: Developing an E-health intervention for improving the biological clock and sleep of University students (“i-sleep & BioClock”): PhD candidate Laura Pape.
- Project PI: “A healthy clock, a healthy mind: restoring 24-h rhythms to combat mood disorders”: postdoc Georgiana Rus-Oswald. - EUniWell Grant: (2021-2022) Collaborative project between 7 European Universities entitled “The Mental Health Symposium: Exploring and Enhancing Mental Health Initiatives and Resources”. Co-applicant (Leiden representative).
- N.W.O. (Dutch Scientific Organization) Onderzoekstalent Grant / Research Talent grant - Principal Investigator – Leiden University (2019- 2023) “Title: 'Rise and fall: Daily fluctuations in suicidal ideation'”: PhD candidate Liia Kivela.
- N.W.O. (Dutch Scientific Organization) Rubicon Grant – Principal Investigator - (2011-2013) post-doctoral research at the Institute of Psychiatry, at the University of Bologna, in Italy. Research focus of the post-doctoral work: “Genetic and environmental pathways to personalized treatment in depression”.
Memberships
- Board member and Head of the Educational committee of the Dutch Association of Sleep-Wake Research.
- Board member and Cluster leader of cluster 2: “Clocks in Health Care” of the BioClock Consortium.
Clinical training
- Emotion Focused Therapy training – Levell I, Level II, and Level III completed
- Masterclasses: Emotion Focused Therapy for Complex Trauma; Empathy and Empathic Attunement in EFT.
- In possession of: LOGO declaration for psychologists.
In the media
Quest Magazine | Wat bepaalt of je een ochtend- of avondmens bent?
EOS Wetenschap | Wat bepaalt of je een ochtend- of avondmens bent?
Invited guest in theater performance “60 In Real Time”, Zuiderstrand Theater, Den Haag (October 2020).
Helan Magazine | Ben jij een ochtend- of een avondmens?
Mare Online | Zondag voelt Leiden de voordelen van de duisternis
Mare Online | Hoe spookstudenten verstrikt raken in hun eigen leugens
Associate professor
- Faculteit der Sociale Wetenschappen
- Instituut Psychologie
- Klinische Psychologie
- Hoeber C.M. Kullberg M.-L.J. Oprel D.A.C. Schoorl M. Van Minnen A. Antypa N. Mouthaan J. De Kleine R.A. Van der Does A.J.W. (2024), Impact of three variants of prolonged exposure therapy on comorbid diagnoses in patients with childhood abuse-related PTSD, Cognitive Behaviour Therapy : .
- Kivelä L.M.M., Mouthaan J., Does A.J.W. van der & Antypa N. (2024), Student mental health during the COVID-19 pandemic: are international students more affected?, Journal of American College Health 72(2): 414-422.
- Pape L.M. van Straten A.Struijs S.Y. Spinhoven P. Antypa N. (2024), Effectiveness of a guided digital self-help intervention to improve sleep and the biological clock in university students – Study protocol for a randomized controlled trial, Internet Interventions 37: 1-10 (100763).
- Kivelä L.M.M. Van der Does A.J.W. Antypa N. (2024), Sleep, hopelessness, and suicidal ideation : An ecological momentary assessment and actigraphy study, Journal of Psychiatric Research 177: 46-52.
- Kivelä L.M.M.,Van der Does A.J.W., Gilissen R. & Antypa N. (2024), Digital phenotypes of real-time suicidal ideation: correlates and consequences, Acta Psychiatrica Scandinavica : 1-13.
- Kivelä L.M.M., Fried E.I., Does A.J.W. van der & Antypa N. (2024), Examining contemporaneous and temporal associations of real-time suicidal ideation using network analysis, Psychologie Magazine : 1-9.
- Lamprou E., Kivelä L.M.M., Rohling J.H.T., Van der Does A.J.W. & Antypa N. (2024), Chronotype, sleep quality, depression and pre-sleep rumination: a diary and actigraphy study, European Journal of Neuroscience : 1-12.
- Kivelä L.M.M., Antypa N., Fried E.I., Schoevers R., Hemert A.M. van, Penninx B.W.J.H. & Does A.J.W. van der (2023), Suicidal ideation across depressive episodes: 9-year longitudinal cohort study, BJPsych Open 9(6): 1-8 (e218).
- Kivelä M.M. Fiß F. Van der Does W. Antypa N. (2023), Examination of Acceptability, Feasibility, and Iatrogenic Effects of Ecological Momentary Assessment (EMA) of Suicidal Ideation, Assessment : .
- Kivelä L.M.M., Riese H., Fakkel T.G., Verkuil B., Penninx B.W.J.H., Lamers F., Does A.J.W. van der & Antypa N. (2022), Chronotype, daily affect and social contact: an ecological momentary assessment study, Psychiatry Research 309: 1-7 (114386).
- Kivelä L.M.M., Mouthaan J., Van der Does A.J.W. & Antypa N. (2022), Student mental health during the COVID-19 pandemic: are international students more affected?, Journal of American College Health : 1-9.
- Kivelä L.M.M., Van der Does A.J.W., Riese H. & Antypa N. (2022), Don't miss the moment: a systematic review of ecological momentary assessment in suicide research, Frontiers in Digital Health 4: 876595.
- Druiven S.J.M., Riese H., Kamphuis J., Haarman B.C.M., Antypa N., Penninx B.W.J.H., Schoevers R.A. & Meesters Y. (2021), Chronotype changes with age: seven-year follow-up from the Netherlands study of depression and anxiety cohort, Journal of Affective Disorders 295: 1118-1121.
- Henrich L.C., Antypa N. & Berg J.F. van den (2021), Sleep quality in students: associations with psychological and lifestyle factors, Current Psychology : 1-8.
- Difrancesco S., Riese H., Merikangas K.R., Shou H.C., Zipunnikov V., Antypa N., Hemert A.M. van, Schoevers R.A., Penninx B.W.J.H. & Lamers F. (2021), Sociodemographic, health and lifestyle, sampling, and mental health determinants of 24-hour motor activity patterns: observational study, Journal of Medical Internet Research 23(2): 1-14 (e20700 ).
- Difrancesco S., Penninx B.W.J.H., Antypa N., Hemert A.M. van, Riese H. & Lamers F. (2021), The day-to-day bidirectional longitudinal association between objective and self-reported sleep and affect: an ambulatory assessment study, Journal of Affective Disorders 283: 165-171.
- Kocevska D., Lysen T.S., Dotinga A., Koopman-Verhoeff M.E., Luijk M.P.C.M., Antypa N., Tiemeier H. & et al. (2021), Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis, Nature Human Behaviour 5(1): 113-122.
- Minaeva O. Riese H. Lamers F. Antypa N. Wichers M. Booij S. (2020), ), Screening for Depression in Daily Life: Development and External Validation of a Prediction Model Based on Actigraphy and Experience Sampling Method, Journal of Medical Internet Research 22(12): e22634.
- Druiven S. J. M. Hovenkamp‐Hermelink J. H. M. Knapen S. E. Kamphuis J. Haarman B. C. M. Penninx B. W. J. H. Antypa N. Meesters Y. Schoevers R. A. Riese H. (2020), Stability of chronotype over a 7‐year follow‐up period and its association with severity of depressive and anxiety symptoms, Depression and Anxiety 37(5): 466–474.
- Minaeva O. Booij S.H. Lamers F. Antypa N. Schoevers R.A. Wichers M. & Riese H. (2020), Level and timing of physical activity during normal daily life in depressed and non-depressed individuals, Translational Psychiatry 10: 1-11 (259).
- Minaeva O., Riese H., Lamers F., Antypa N., Wichers M. & Booij S. (2020), Screening for depression in daily life: development and external validation of a prediction model based on actigraphy and experience sampling method, Journal of Medical Internet Research 22(12): e22634.
- Kivelä L., Krause-Utz A., Mouthaan J., Schoorl M., Kleine R. de, Elzinga B., Eikelenboom M., Penninx B.W.J.H., Does W. van der & Antypa N. (2019), Longitudinal course of suicidal ideation and predictors of its persistence – A NESDA study, Journal of Affective Disorders 257: 365-375.
- Druiven S.J.M., Knapen S.E., Penninx B.W.J.H., Antypa N., Schoevers R.A., Riese H. & Meesters Y. (2019), Can chronotype function as predictor of a persistent course of depressive and anxiety disorder?, Journal of Affective Disorders 242: 159-164.
- Knapen S.E., Riemersma-Van der Lek R.F., Antypa N., Meesters Y., Penninx .B.W.J.H. & Schoevers R.A. (2018), Social jetlag and depression status: Results obtained from the Netherlands Study of Depression and Anxiety, Chronobiology International 35(1): 1-7.
- Kerpershoek M.L., Antypa N. & Van den Berg J.F. (2018), Evening use of caffeine moderates the relationship between caffeine consumption and subjective sleep quality in students, Journal of Sleep Research 27(5): e12670.
- Van den Berg J.F., Kivelä L. & Antypa N. (2018), Chronotype and depressive symptoms in students: An investigation of possible mechanisms, Chronobiology International 35(9): 1248-1261.
- Kivelä L., Papadopoulos M. & Antypa N. (2018), Chronotype and Psychiatric Disorders, Current Sleep Medicine Reports 4(2): 94-103.
- Solis E., Antypa N., Conijn J.M., Kelderman H. & Does A.J.W. van der (2017), Psychometric Properties of the Leiden Index of Depression Sensitivity (LEIDS), Psychological Assessment 29(2): 158-171.
- Antypa N., Verkuil B., Molendijk M.L., Schoevers R., Penninx B.W.J.H. & Van der Does A.J.W. (2017), Associations between chronotypes and psychological vulnerability factors of depression, Chronobiology International 34(8): 1125-1135.
- Tollenaar M.S., Molendijk M.L., Penninx B.W., Milaneschi Y. & Antypa N. (2017), The association of childhood maltreatment with depression and anxiety is not moderated by the oxytocin receptor gene, European Archives of Psychiatry and Clinical Neuroscience 267(6): 517–526.
- Balestri M., Crisafulli C., Donato L., Giegling I., Calati R, Antypa N., Schneider B., Marusic D., Tarozzi M.E., Marusic D, Paragi M., Hartmann A.M., Konte B., Marsano A., Serretti A. & Rujescu D. (2017), Nine differentially expressed genes from a post mortem study and their association with suicidal status in a sample of suicide completers, attempters and controls, Journal of Psychiatric Research 91: 98-104.
- Antypa N., Vogelzangs N., Meesters Y., Schoevers R. & Penninx B.W. (2016), Chronotype associations with depression and anxiety disorders in a large cohort study, Depression and Anxiety 33(1): 75-83.
- Antypa N., Souery D., Tomasini M., Albani D., Fusco F., Mendlewicz J. & Serretti A. (2016), Clinical and genetic factors associated with suicide in mood disorder patients, European Archives of Psychiatry and Clinical Neuroscience 266(2): 181–193.
- Drago A., Winding T.N. & Antypa N. (2016), Videoconferencing in psychiatry, a meta-analysis of assessment and treatment, European Psychiatry 36: 29-37.
- Antypa N., Calati R. & Serretti A. (2014), The neuropsychological hypothesis of antidepressant drug action revisited. CNS Neurol Disord Drug Targets, CNS & Neurological Disorders - Drug Targets 13(10): 1722-1739.
- Antypa N., Drago A. & Serretti A. (2013), The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes, Neuroscience & Biobehavioral Reviews 37(8): 1597-1610.
- Verhoeven F.E.A., Booij L., Kruijt A.-W., Cerit H., Antypa N. & Does A.J.W. van der (2012), The effects of MAOA genotype, childhood trauma, and sex on trait and state-dependent aggression, Brain and Behavior 2(6): 806-813.
- Antypa N., Smelt A.H.M., Strengholt A. & Does A.J.W. van der (2012), Effects of omega-3 fatty acid supplementation on mood and emotional information processing in recovered depressed individuals, Journal of Psychopharmacology 26(5): 738-743.
- Mandelli F., Antypa N., Nearchou F.A., Valopoulos C., Stefanis C.N., Serretti A. & Stefanis N.C. (2012), The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism, Journal of Affective Disorders 142(1-3): 82-89.
- Antypa N., Mandelli L., Nearchou F.A., Vaiopoulos C., Stefanis C.N., Serretti A. & Stefanis N.C. (2012), The 3111T/C polymorphism interacts with stressful life events to influence patterns of sleep in females, Chronobiology International 29(7): 891-897.
- Drost J., Does A.J.W. van der, Antypa N., Zitman F.G., Dyck R. van & Spinhoven P. (2012), General, Specific and Unique Cognitive Factors Involved in Anxiety and Depressive Disorders, Cognitive Therapy and Research 36(6): 621-633.
- Antypa N. (21 June 2011), Cognitive vulnerability to depression : genetic and environmental influences (Dissertatie. Psychology, Faculty of Social and Behavioural Sciences, Leiden University). Supervisor(s): Does A.J.W. van der.
- Klok M.D., Giltay E.J., Does A.J.W. van der, Geleijnse J.M., Antypa N., Penninx B.W.J.H., Geus E.J.C. de, Willemsen F., Boomsma D.I., Leeuwen N. van, Zitman F.G., Kloet E.R. de & Rijk R.H. de (2011), A common and functional mineralocorticoid receptor haplotype enhances optimism and protects against depression in females, Translational Psychiatry 1: e62.
- Antypa N., Cerit H., Kruijt A.-W., Verhoeven F.E.A. & Van der Does A.J.W. (2011), Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions, Neuroscience 172(1): 303-313.
- Antypa N. & Does A.J.W. van der (2010), Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression, Genes Brain and Behavior 9: 615-620.
- Antypa N., Does A.J.W. van der & Penninx B.W. (2010), Cognitive reactivity: Investigation of a potentially treatable marker of suicide risk in depression, Journal of Affective Disorders 122: 46-52.
- Putman P., Antypa N., Crysovergi P. & Does A.J.W. van der (2010), Exogenous cortisol acutely influences motivated decision making in healthy young men, 208: 257-263.
- Antypa N., Does A.J.W. van der, Smelt A.H.M. & Rogers R.D. (2009), Omega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteers, Journal of Psychopharmacology 23: 831-840.
- psychotherapy