Marie-José Goumans
Professor Molecular Cardiovascular Cell Biology
- Name
- Prof.dr. M.J.T.H. Goumans
- Telephone
- +31 71 526 9277
- m.j.t.h.goumans@lumc.nl
- ORCID iD
- 0000-0001-9344-6746
Marie-José Goumans is professor of cardiovascular cell biology at the department of cell and chemical biology at the LUMC. In 2009 Marie-José Goumans was accepted as a member of the Young Academie, the junior section of the Dutch Royal Academy of Sciences, consisting of the 50 most prominent scientist under 45 years of age). In 2004, she received a prestigious VIDI fellowship of the Netherlands Organisation of Science
More information about Marie-José Goumans
See also
Cardiovascular regenerative medicine
The focus of the research is cardiovascular regeneration. We focus on cardiac (progenitor) cells and signal transduction pathways to develop new approaches to improve cardiovascular recovery upon injury or disease. Cells respond to growth signals from their environment and interaction between cells and the extracellular matrix is important for proper differentiation. We aim to unravel the signals that the embryo uses and translated that knowledge to ‘tissue engineer’ heart and vessels in a dish, improve (stem) cell transplantation, and stimulate endogenous repair.
The development of heart and blood vessels is a highly coordinated process. Optimal regulation of growth factor signalling is crucial for normal embryonic development, as well as normal physiology in adult life. Transforming growth factor beta (TGF-β) is one of the growth factor families important for the differentiation of stem cells into the building blocks of heart and blood vessels, both in a dish and in real life. Furthermore, mutations in the TGF-β signal transduction pathway underlie the hereditary cardiovascular disorders pulmonary arterial hypertensions and Rendu Osler Weber’s disease. Disturbed TGF-β signalling also contributes to fibrosis of the heart and the development of heart failure.
For our study of cardiac tissue repair we make use of (stem) cells present in the human heart. Cardiac progenitor cells, isolated from human heart biopsies, are able to differentiate into all cell types present in the heart, and improve heartfunction when transplanted into the myocardial wall after myocardial infarction. Epicardial derived cells (EPDCs) are also important for cardiac repair. EPDCs will not differentiate into new cardiomyoctes but will support the newly formed cells and provide instructive signals to the healing heart wall. These two human cardiac cell populations offer the possibility to generate ‘heart tissues’ to study their behaviour in 3D. Growth factors and exosomes secreted by cardiac cells have a positive effect on healing of cardiac tissue. Therefore, CPCs and EPDCs are an excellent cell model to explore the impact of paracrine signalling, such as TGF-β, on cardiovascular regeneration. One of the research themes is therefore if, by activating endogenous repair mechanisms or in vitro tissue engineering, we can improve the regenerative capacity of the heart.
Academic career
Marie-José Goumans, did her PhD in cardiovascular development at the Hubrecht Laboratory, investigating the role of TGFβ in cardiovascular development under the supervision of Christine Mummery. She received her PhD in 1999 with a thesis entitled: Functional analysis of TGFβsignalling in early mouse development. She started her postdoctoral training at the Ludwig Institute for Cancer research in Uppsala, Sweden and the Netherlands Cancer Institute where she made important contributions on how TGFβ affects endothelial cell behaviour. In 2003, Marie Jose was appointed assistant professor at the dept of cardiology, Utrecht UMC, where she initiated studies on cardiac progenitor cells. In 2004, she was awarded a prestigious NWO VIDI grant to unravel the role of cardiac progenitor cells in heart regeneration. In 2008, Marie - José Goumans moved to the department of Molecular Cell Biology, at the Leiden UMC and continued her studies on cardiac progenitor cell biology, in particular the role of the TGFβ superfamily. In 2009, she became a member of the Young Academy of the Royal Dutch Academy of Science. In February 2012, she was appointed professor of molecular cardiovascular cell biology at the University of Leiden, which she accepted with her inaugural lecture entitled “hart voor de wetenschap” on November 2nd 2012.
Prizes and honourable appointments
- 2004: Bekalis award for young scientists
- 2004: VIDI ZonMW, Career Development Awardee
- 2009: Member of the young academy of science of the royal Dutch academy of art and science
Professor Molecular Cardiovascular Cell Biology
- Faculteit Geneeskunde
- Divisie 4
- Cel en Chemische biologie
- Mercnik, M.H.; Schliefsteiner, C.; Fluhr, H.; Sanchez-Duffhues, G.; Goumans, M.J. & Wadsack, C. (2023), A PARACRINE CROSSTALK BETWEEN HOFBAUER CELLS (HBCS) AND FETO-PLACENTAL ENDOTHELIAL CELLS (FPECS) CONTRIBUTES TO THE ENDOTHELIAL TO MESENCHYMAL TRANSITION (ENDOMT) IN EARLY ONSET PREECLAMPSIA (EO PE), Placenta 140: E88-E88.
- Mercnik, M.H.; Telebar, F.; Schaffer, S.; Fluhr, H.; Sanchez-Duffhues, G.; Goumans, M.J.E. & Wadsack, C. (2023), ACTIVIN RECEPTOR-LIKE-KINASE-2 (ALK2)-SNAIL PATHWAY DRIVES ENDOTHELIAL TO MESENCHYMAL TRANSITION (ENDOMT) IN FETOPLACENTAL ENDOTHELIAL CELLS (FPEC) OF EARLY ONSET PREECLAMPSIA (EO-PE), Placenta 140: E77-E77.
- Streef, T.J.; Groeneveld, E.J.; Herwaarden, T. van; Hjortnaes, J.; Goumans, M.J. & Smits, A.M. (2023), Single-cell analysis of human fetal epicardium reveals its cellular composition and identifies CRIP1 as a modulator of EMT, Stem Cell Reports 18(7): 1421-1435.
- Wits, M.; Becher, C.; Man, F. de; Sanchez-Duffhues, G. & Goumans, M.J. (2023), Sex-biased TGFβ signalling in pulmonary arterial hypertension, Cardiovascular Research 119(13): 2262-2277.
- Peters, M.C.; Kruithof, B.P.T.; Bouten, C.V.C.; Voets, I.K.; Bogaerdt, A. van den; Goumans, M.J. & Wijk, A. van (2023), Preservation of human heart valves for replacement in children with heart valve disease, Cell and Tissue Banking.
- Bekedam, F.T.; Goumans, M.J.; Bogaard, H.J.; Man, F.S. de & Lluciá-Valldeperas, A. (2023), Molecular mechanisms and targets of right ventricular fibrosis in pulmonary hypertension, Pharmacology and Therapeutics 244.
- Mostert, D.; Jorba, I.; Groenen, B.G.W.; Passier, R.; Goumans, M.J.T.H.; Boxtel, H.A. van; Kurniawan, N.A.; Bouten, C.V.C. & Klouda, L. (2023), Methacrylated human recombinant collagen peptide as a hydrogel for manipulating and monitoring stiffness-related cardiac cell behavior, iScience 26(4).
- Wessels, J.N.; Wezenbeek, J. van; Rover, J. de; Smal, R.; Llucià-Valldeperas, A.; Celant, L.R.; Marcus, J.T.; Meijboom, L.J.; Groeneveldt, J.A.; Oosterveer, F.P.T.; Winkelman, T.A.; Niessen, H.W.M.; Goumans, M.J.; Bogaard, H.J.; Noordegraaf, A.V.; Strijkers, G.J.; Handoko, M.L.; Westerhof, B.E. & Man, F.S. de (2023), Right atrial adaptation to precapillary pulmonary hypertension, Journal of the American College of Cardiology 82(8).
- Braams, N.J.; Kianzad, A.; Wezenbeek, J. van; Wessels, J.N.; Jansen, S.M.A.; Andersen, S.; Boonstra, A.; Nossent, E.J.; Marcus, J.T.; Bayoumy, A.A.; Becher, C.; Goumans, M.J.; Andersen, A.; Noordegraaf, A.V.; Man, F.S. de; Bogaard, H.J. & Meijboom, L.J. (2023), Long-term effects of pulmonary endarterectomy on right ventricular stiffness and fibrosis in chronic thromboembolic pulmonary hypertension, Circulation: Heart Failure 16(10).
- Gartner, T.C.L.B.; Wang, Y.; Leiteris, L.; Adrichem, I. van; Marsman, J.; Goumans, M.J.; Bouten, C.V.C.; Sluijter, J.P.G.; Toonder, J.M.J.D.; Suyker, W.J.L. & Hjortnaes, J. (2023), Cyclic strain has antifibrotic effects on the human cardiac fibroblast transcriptome in a human cardiac fibrosis-on-a-chip platform, Journal of the Mechanical Behavior of Biomedical Materials 144.
- Harlaar, N.; Dekker, S.O.; Zhang, J.; Snabel, R.R.; Veldkamp, M.W.; Verkerk, A.O.; Fabres, C.C.; Schwach, V.; Lerink, L.J.S.; Rivaud, M.R.; Mulder, A.A.; Corver, W.E.; Goumans, M.J.T.H.; Dobrev, D.; Klautz, R.J.M.; Schalij, M.J.; Veenstra, G.J.C.; Passier, R.; Brakel, T.J. van; Pijnappels, D.A. & Vries, A.A.F. de (2022), Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation, Nature Biomedical Engineering 6.
- Lodrini, A.M.; Bogunovic, N.; Kruithof, B.P.; Smits, A.; Vries, A.A. de & Goumans, M.J. (2022), Developing regenerative therapies targeting cardiomyocytes using organotypic slice culture from human adult ventricular myocardium, Cardiovascular Research 118(SUPPL 1).
- Mostert, D.; Groenen, B.; Klouda, L.; Passier, R.; Goumans, M.J.; Kurniawan, N.A. & Bouten, C.V.C. (2022), Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts, APL BIOENGINEERING 6(4).
- Wezenbeek, J. van; Llucia-Valldeperas, A.; Groeneveldt, J.A.; Sanchez-Duffhues, G.; Smal, R.; Pan, X.; Noordegraaf, A.V.; Bogaard, H.J.; Goumans, M. & Man, F.S. de (2022), Increased Bone Morphogenetic Protein 10 Activity Is Associated with Increased Right Atrial Wall Stress and Disease Severity in Pulmonary Hypertension, American Journal of Respiratory and Critical Care Medicine 205.
- Jong, A. de; Sier, V.Q.; Peters, H.A.B.; Schilder, N.K.M.; Jukema, J.W.; Goumans, M.J.T.H.; Quax, P.H.A. & Vries, M.R. de (2022), Interfering in the ALK1 pathway results in macrophage-driven outward remodeling of murine vein grafts, Frontiers in Cardiovascular Medicine 8.
- Wezenbeek, J. van; Groeneveldt, J.A.; Llucia-Valldeperas, A.; Bruggen, C.E. van der; Jansen, S.M.A.; Smits, A.J.; Smal, R.; Leeuwen, J.W. van; Remedios, C. dos; Keogh, A.; Humbert, M.; Dorfmuller, P.; Mercier, O.; Guignabert, C.; Niessen, H.W.M.; Handoko, M.L.; Marcus, J.T.; Meijboom, L.J.; Oosterveer, F.P.T.; Westerhof, B.E.; Heijboer, A.C.; Bogaard, H.J.; Noordegraaf, A.V.; Goumans, M.J. & Man, F.S. de (2022), Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort, Journal of Heart and Lung Transplantation 41(4): 445-457.
- Llucia-Valldeperas, A.; Smal, R.; Wijnker, P.J.M.; Velden, J. van der; Bogaard, H.J.; Vonk-Noordegraaf, A.; Goumans, M.J. & Man, F.S. de (2022), ONGOING DEVELOPMENT OF A HUMAN 3-DIMENSIONAL TISSUE-ENGINEERED MODEL TO STUDY RIGHT HEART FAILURE, Tissue Engineering Part A 28: S172-S173.
- Gartner, T.C.L.B.; Crnko, S.; Leiteris, L.; Adrichem, I. van; Laake, L.W. van; Bouten, C.V.C.; Goumans, M.J.; Suyker, W.J.L.; Sluijter, J.P.G. & Hjortnaes, J. (2022), Pirfenidone has anti-fibrotic effects in a tissue-engineered model of human cardiac fibrosis, Frontiers in Cardiovascular Medicine 9.
- Wezenbeek, J.; Wessels, J.N.; Niessen, H.W.M.; Marcus, T.; Meijboom, L.J.; Noordegraaf, A.V.; Goumans, M.; Bogaard, H.J. & Man, F.S. de (2022), Right Atrial Adaptation to Pressure-Overload in Pulmonary Arterial Hypertension, American Journal of Respiratory and Critical Care Medicine 205.
- Wezenbeek, J. van; Kianzad, A.; Bovenkamp, A. van de; Wessels, J.; Mouratoglou, S.A.; Braams, N.J.; Jansen, S.M.A.; Meulblok, E.; Meijboom, L.J.; Marcus, J.T.; Noordegraaf, A.V.; Goumans, M.J.; Bogaard, H.J.; Handoko, M.L. & Man, F.S. de (2022), Right ventricular and right atrial function are less compromised in pulmonary hypertension secondary to heart failure with preserved ejection fraction, Circulation: Heart Failure 15(2).
- Luyckx, I.; Verstraeten, A.; Goumans, M.J. & Loeys, B. (2022), SMAD6-deficiency in human genetic disorders, npj Genomic Medicine 7(1).
- Kohela, A.; Kampen, S.J. van; Moens, T.; Wehrens, M.; Molenaar, B.; Boogerd, C.J.; Monshouwer-Kloots, J.; Perini, I.; Goumans, M.J.; Smits, A.M.; Tintelen, J.P. van & Rooij, E. van (2021), Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy, Science Translational Medicine 13(612).
- Ebeid, D.E.; Khalafalla, F.G.; Broughton, K.M.; Monsanto, M.M.; Esquer, C.Y.; Sacchi, V.; Hariharan, N.; Korski, K.I.; Moshref, M.; Emathinger, J.; Cottage, C.T.; Quijada, P.J.; Nguyen, J.H.; Alvarez, R.; Volkers, M.; Konstandin, M.H.; Wang, B.Y.J.; Firouzi, F.; Navarrete, J.M.; Gude, N.A.; Goumans, M.J. & Sussman, M.A. (2021), Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGF beta signalling, Cardiovascular Research 117(1): 201-211.
- Smolders, V.F.E.D.; Lodder, K.; Rodriguez, C.; Tura-Ceide, O.; Barbera, J.A.; Jukema, J.W.; Quax, P.H.A.; Goumans, M.J. & Kurakula, K. (2021), The inflammatory profile of CTEPH-derived endothelial cells is a possible driver of disease progression, Cells 10(4).
- Kruithof, B.P.T.; Pol, V. van de; , T. los; Lodder, K.; Gourabi, B.M.; DeRuiter, M.C.; Goumans, M.J. & Marsan, N.A. (2021), New calcification model for intact murine aortic valves, Journal of Molecular and Cellular Cardiology 156: 95-104.
- Llucia-Valldeperas, A.; Wezenbeek, J. van; Goumans, M.J. & Man, F.S. de (2021), The battle of new biomarkers for right heart failure in pulmonary hypertension: is the queen of hearts NT-proBNP defeated at last?, European Respiratory Journal 57(4).
- Vegh, A.M.D.; Verkerk, A.O.; Ortega, L.C.; Wang, J.A.; Geerts, D.; Klerk, M.; Lodder, K.; Nobel, R.; Tijsen, A.J.; Devalla, H.D.; Christoffels, V.M.; Medina-Ramirez, M.; Smits, A.M.; Tan, H.L.; Wilders, R.; Goumans, M.J.T.H. & Boink, G.J.J. (2021), Toward biological pacing by cellular delivery of Hcn2/SkM1, Frontiers in Physiology 11.
- Hagdorn, Q.A.J.; Kurakula, K.; Koop, A.M.C.; Bossers, G.P.L.; Mavrogiannis, E.; Leusden, T. van; Feen, D.E. van der; Boer, R.A. de; Goumans, M.J.T.H. & Berger, R.M.F. (2021), Volume load-induced right ventricular failure in rats is not associated with myocardial fibrosis, Frontiers in Physiology 12.
- Bakker, D.E.M. de; Bouwman, M.; Dronkers, E.; Simoes, F.C.; Riley, P.R.; Goumans, M.J.; Smits, A.M. & Bakkers, J. (2021), Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration, DEVELOPMENT 148(19).
- Peterson, J.C.; Kelder, T.P.; Goumans, M.J.T.H.; Jongbloed, M.R.M. & DeRuiter, M.C. (2021), The role of cell tracing and fate mapping experiments in cardiac outflow tract development, new opportunities through emerging technologies, Journal of Cardiovascular Development and Disease 8(5).
- Zwanenburg, F.; DeRuiter, M.C.; Wisse, L.J.; Munsteren, C.J. van; Bartelings, M.M.; Goumans, M.J.; Harkel, A.D.J. ten; Jongbloed, M.R.M. & Haak, M.C. (2021), Deficient myocardial organization and pathological fibrosis in fetal aortic stenosis-association of prenatal ultrasound with postmortem histology, Journal of Cardiovascular Development and Disease 8(10).
- Bakker, W.; Dingenouts, C.K.E.; Lodder, K.; Wiesmeijer, K.C.; Jong, A. de; Kurakula, K.; Mager, H.J.J.; Smits, A.M.; Vries, M.R. de; Quax, P.H.A. & Goumans, M.J.T.H. (2021), BMP receptor inhibition enhances tissue repair in endoglin heterozygous mice, International Journal of Molecular Sciences 22(4).
- Sier, V.Q.; Vorst, J.R. van der; Quax, P.H.A.; Vries, M.R. de; Zonoobi, E.; Vahrmeijer, A.L.; Dekkers, I.A.; Geus-Oei, L.F. de; Smits, A.M.; Cai, W.B.; Sier, C.F.M.; Goumans, M.J.T.H. & Hawinkels, L.J.A.C. (2021), Endoglin/CD105-based imaging of cancer and cardiovascular diseases, International Journal of Molecular Sciences 22(9).
- Dronkers, E.; Herwaarden, T. van; Brakel, T.J. van; Sanchez-Duffhues, G.; Goumans, M.J. & Smits, A.M. (2021), Activin A and ALK4 identified as novel regulators of Epithelial to Mesenchymal Transition (EMT) in human epicardial cells, Frontiers in Cell and Developmental Biology 9.
- Ge, Y.; Smits, A.M.; Liu, J.; Zhang, J.; Brakel, T.J. van; Goumans, M.J.T.H.; Jongbloed, M.R.M. & Vries, A.A.F. de (2021), Generation, characterization, and application of inducible proliferative adult human epicardium-derived cells, Cells 10(8).
- Llucia-Valldeperas, A.; Wezenbeek, J. van; Groeneveldt, J.A.; Sanchez-Duffhues, G.; Smal, R.; Pan, X.; Noordegraaf, A.V.; Bogaard, H.J.; Goumans, M. & Man, F.S. de (2021), Increased BMP10 Levels Are Associated with Pulmonary Hypertension, American Journal of Respiratory and Critical Care Medicine 203(9).
- Lodrini, A.M. & Goumans, M.J. (2021), Cardiomyocytes cellular phenotypes after myocardial infarction, Frontiers in Cardiovascular Medicine 8.
- Tura-Ceide, O.; Smolders, V.F.E.D.; Aventin, N.; Moren, C.; Guitart-Mampel, M.; Blanco, I.; Piccari, L.; Osorio, J.; Rodriguez, C.; Rigol, M.; Solanes, N.; Malandrino, A.; Kurakula, K.; Goumans, M.J.; Quax, P.H.A.; Peinado, V.I.; Castella, M. & Barbera, J.A. (2021), Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension, Scientific Reports 11(1).
- Llucia-Valldeperas, A.; Smal, R.; Bekedam, F.T.; Ce, M.; Pan, X.K.; Manz, X.D.; Wijnker, P.J.M.; Vonk-Noordegraaf, A.; Bogaard, H.J.; Goumans, M.J. & Man, F.S.D. (2021), Development of a 3-dimensional model to study right heart dysfunction in pulmonary arterial hypertension, Cells 10(12).
- Karkampouna, S.; Helm, D. van der; Scarpa, M.; Hoek, B. van; Verspaget, H.W.; Goumans, M.J.; Coenraad, M.J.; Kruithof, B.P.T. & Julio, M.K.D. (2021), Oncofetal protein CRIPTO is involved in wound healing and fibrogenesis in the regenerating liver and is associated with the initial stages of cardiac fibrosis, Cells 10(12).
- Sanada, T.J.; Sun, X.Q.; Happe, C.; Guignabert, C.; Tu, L.; Schalij, I.; Bogaard, H.J.; Goumans, M.J. & Kurakula, K. (2021), Altered TGF beta/SMAD signaling in human and rat models of pulmonary hypertension, Cells 10(1).
- Ventura, F.; Williams, E.; Ikeya, M.; Bullock, A.N.; Dijke, P. ten; Goumans, M.J. & Sanchez-Duffhues, G. (2021), Challenges and opportunities for drug repositioning in fibrodysplasia ossificans progressiva, Biomedicines 9(2).
- Kurakula, K.; Hagdorn, Q.A.J.; Feen, D.E. van der; Noordegraaf, A.V.; Dijke, P. ten; Boer, R.A. de; Bogaard, H.J.; Goumans, M.J. & Berger, R.M.F. (2021), Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-beta signalling, Angiogenesis 25.
- Kenswil, K.J.G.; Pisterzi, P.; Sanchez-Duffhues, G.; Dijk, C. van; Lolli, A.; Knuth, C.; Vanchin, B.; Jaramillo, A.C.; Hoogenboezem, R.M.; Sanders, M.A.; Feyen, J.; Cupedo, T.; Costa, I.G.; Li, R.H.; Bindels, E.M.J.; Lodder, K.; Blom, B.; Bos, P.K.; Goumans, M.J.; Dijke, P. ten; Farrell, E.; Krenning, G. & Raaijmakers, M.H.G.P. (2021), Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation, Cell Stem Cell 28(4): 653-+.
- Vinuesa, A.G. de; Sanchez-Duffhues, G.; Blaney-Davidson, E.; Caam, A. van; Lodder, K.; Ramos, Y.; Kloppenburg, M.; Meulenbelt, I.; Kraan, P. van der; Goumans, M.J. & Dijke, P. ten (2021), Cripto favors chondrocyte hypertrophy via TGF-beta SMAD1/5 signaling during development of osteoarthritis, The Journal of Pathology 255(3).
- Sun, X.Q.; Peters, E.L.; Schalij, I.; Axelsen, J.B.; Andersen, S.; Kurakula, K.; Gomez-Puerto, M.C.; Szulcek, R.; Pant, X.K.; Bos, D.D.G.; Schiepers, R.E.J.; Andersen, A.; Goumans, M.J.; Noordegraaf, A.V.; Laarse, W.J. van der; Man, F.S. de & Bogaard, H.J. (2021), Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension, American Journal of Respiratory Cell and Molecular Biology 64(3): 331-343.
- Kurakula, K.; Smolders, V.F.E.D.; Tura-Ceide, O.; Jukema, J.W.; Quax, P.H.A. & Goumans, M.J. (2021), Endothelial dysfunction in pulmonary hypertension: cause or consequence?, Biomedicines 9(1).
- Schoonderwoerd, M.J.A.; Goumans, M.J.T.H. & Hawinkels, L.J.A.C. (2020), Endoglin: beyond the Endothelium, Biomolecules 10(2).
- Dronkers, E.; Wauters, M.M.M.; Goumans, M.J. & Smits, A.M. (2020), Epicardial TGF beta and BMP signaling in cardiac regeneration: what lesson can we learn from the developing heart?, Biomolecules 10(3).
- Szulcek, R.; Sanchez-Duffhues, G.; Rol, N.; Pan, X.K.; Tsonaka, R.; Dickhoff, C.; Yung, L.M.; Manz, X.D.; Kurakula, K.; Kielbasa, S.M.; Mei, H.L.; Timens, W.; Yu, P.B.; Bogaard, H.J. & Goumans, M.J. (2020), Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells, Angiogenesis 23(4): 699-714.
- Costa, A.; Balbi, C.; Lodder, K.; Garbati, P.; Herwaarden, T. van; Moimas, S.; Palmeri, A.; Biasio, P. de; Goumans, M.J.; Giacca, M.; Moccia, F.; Smits, A.M.; Barile, L. & Bollini, S. (2020), Exploiting the human amniotic fluid stem cell secretome for myocardial renewal, Vascular Pharmacology 132.
- Dijk, C.G.M. van; Louzao-Martinez, L.; Mulligen, E. van; Boermans, B.; Demmers, J.A.A.; Bosch, T.P.P. van den; Goumans, M.J.; Duncker, D.J.; Verhaar, M.C. & Cheng, C. (2020), Extracellular matrix analysis of human renal arteries in both quiescent and active vascular state, International Journal of Molecular Sciences 21(11).
- Ge, Y.; Smits, A.M.; Munsteren, J.C. van; Gittenberger-de Groot, A.C.; Poelmann, R.E.; Brakel, T.J. van; Schalij, M.J.; Goumans, M.J.; DeRuiter, M.C. & Jongbloed, M.R.M. (2020), Human epicardium-derived cells reinforce cardiac sympathetic innervation, Journal of Molecular and Cellular Cardiology 143: 26-37.
- Pol, V. van de; Vos, M.; DeRuiter, M.C.; Goumans, M.J.; Vries, C.J.M. de & Kurakula, K. (2020), LIM-only protein FHL2 attenuates inflammation in vascular smooth muscle cells through inhibition of the NF kappa B pathway, Vascular Pharmacology 125.
- Kroone, C.; Vos, M.; Rademakers, T.; Kuijpers, M.; Hoogenboezem, M.; Buul, J. van; Heemskerk, J.W.M.; Ruf, W.; Vlieg, A.V.; Versteeg, H.H.; Goumans, M.J.; Vries, C.J.M. de; Kurakula, K. & INVENT Consortium (2020), LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis, Haematologica 105(6): 1677-1685.
- Gomez-Puerto, M.C.; Sun, X.Q.; Schalij, I.; Orriols, M.; Pan, X.K.; Szulcek, R.; Goumans, M.J.; Bogaard, H.J.; Zhou, Q. & Dijke, P. ten (2020), MnTBAP reverses pulmonary vascular remodeling and improves cardiac function in experimentally induced pulmonary arterial hypertension, International Journal of Molecular Sciences 21(11).
- Provencher, S.; Boucherat, O.; Berger, R.M.F.; Goumans, M.J. & Bonnet, S. (2020), More insights into the association between RVX-208 and pulmonary arterial hypertension reply.
- Turaihi, A.H.; Serne, E.H.; Molthoff, C.F.M.; Koning, J.J.; Knol, J.; Niessen, H.W.; Goumans, M.J.T.H.; Poelgeest, E.M. van; Yudkin, J.S.; Smulders, Y.M.; Jimenez, C.R.; Hinsbergh, V.W.M. van & Eringa, E.C. (2020), Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression, and Glucose Uptake in Muscle Through Adipomuscular Arterioles, Diabetes 69(4): 603-613.
- Ma, J.; Sanchez-Duffhues, G.; Goumans, M.J. & Dijke, P. ten (2020), TGF-beta-induced endothelial to mesenchymal transition in disease and tissue engineering, Frontiers in Cell and Developmental Biology 8.
- Happe, C.; Kurakula, K.; Sun, X.Q.; Bos, D.D.G.; Rol, N.; Guignabert, C.; Tu, L.; Schalij, I.; Wiesmeijer, K.C.; Tura-Ceide, O.; Noordegraaf, A.V.; Man, F.S. de; Bogaard, H.J. & Goumans, M.J. (2020), The BMP receptor 2 in pulmonary arterial hypertension, Cells 9(6).
- Botros, L.; Szulcek, R.; Jansen, S.M.A.; Kurakula, K.; Goumans, M.J.T.H.; Kuilenburg, A.B.P. van; Noordegraaf, A.V.; Man, F.S. de; Aman, J. & Bogaard, H.J. (2020), The Effects of Mercaptopurine on Pulmonary Vascular Resistance and BMPR2 Expression in Pulmonary Arterial Hypertension.
- Costa, A.; Balbi, C.; Garbati, P.R.; Lodder, K.; Herwaarden, T. van; Turturo, S.; Palmeri, A.; Biasio, P. de; Barile, L.; Goumans, M.; Smits, A.M. & Bollini, S. (2020), The human amniotic fluid stem cell secretome exerts cardio-active paracrine potential for myocardial repair and regeneration, Cytotherapy 22(5): S171-S171.
- Kruithof, B.P.T.; Paardekooper, L.; Hiemstra, Y.L.; Goumans, M.J.; Palmen, M.; Delgado, V.; Klautz, R.J.M. & Marsan, N.A. (2020), Stress-induced remodelling of the mitral valve: a model for leaflet thickening and superimposed tissue formation in mitral valve disease, Cardiovascular Research 116(5): 931-943.
- Kurakula, K.B.; Sung, X.Q.; Feen, D.E. van der; Hagdorn, Q.A.J.; Bogaard, H.J.; Berger, R.M. & Goumans, M.J. (2020), Selective inhibition of Histone deacetylases reverses vascular remodelling and improves right ventricle function in pulmonary hypertension, European Heart Journal 41: 3807-3807.
- Kruithof, B.; Pol, V. van de; , T. los; Lodder, K.; Ruiter, M.C. de; Goumans, M.J.; Schalij, M.J. & Marsan, N.A. (2020), New ex vivo calcification model for intact murine aortic valves, European Heart Journal 41: 3718-3718.
- Jong, A. de; Sier, V.Q.; Peters, H.A.B.; Jukema, J.W.; Goumans, M.J.; Quax, P.A.H. & Vries, M.R. de (2020), Inhibition of BMP9 and BMP10 signalling by the ALK1-Fc Ligand Trap enhances systemic inflammation and increases vein graft atherosclerosis, European Heart Journal 41: 3828-3828.
- Driessen, H.E.; Fontes, M.S.; Stuijvenberg, L. van; Brans, M.A.; Goumans, M.J.; Vos, M.A. & Veen, T.A. van (2020), A combined CaMKII inhibition and mineralocorticoid receptor antagonism via eplerenone inhibits functional deterioration in chronic pressure overloaded mice, Journal of Cellular and Molecular Medicine 24(15): 8417-8429.
- Botros, L.; Szulcek, R.; Jansen, S.; Smits, J.; Phelp, P.; Kurakula, K.; Goumans, M.; Nossent, E.J.; Boonstra, A.; Noordegraaf, A.V.; Man, F. de; Aman, J. & Bogaard, H.J. (2020), Anti-Proliferative Therapy with 6-Mercaptopurine Improves Hemodynamics and BMPR2 Expression in Pulmonary Arterial Hypertension, American Journal of Respiratory and Critical Care Medicine 201.
- Streef, T.J.; Herwaarden, T. van; Smits, A.M. & Goumans, M.J. (2020), Single-cell RNA sequencing of human fetal epicardium reveals novel markers and regulators of EMT, European Heart Journal 41: 3574-3574.
- Provencher, S.; Boucherat, O.; Berger, R.M.F.; Goumans, M.J. & Bonnet, S. (2020), BET signaling: a novel therapeutic target for pulmonary hypertension? reply.
- Bons, L.R.; Geenen, L.W.; Hoven, A.T. van den; Dik, W.A.; Bosch, A.E. van den; Duijnhouwer, A.L.; Siebelink, H.M.J.; Budde, R.P.J.; Boersma, E.; Wessels, M.W.; Laar, I.M.B.H. van de; DeRuiter, M.C.; Goumans, M.J.; Loeys, B.L. & Roos-Hesselink, J.W. (2020), Blood biomarkers in patients with bicuspid aortic valve disease, Journal of Cardiology 76(3): 287-294.
- Sanchez-Duffhues, G.; Williams, E.; Goumans, M.J.; Heldin, C.H. & Dijke, P. ten (2020), Bone morphogenetic protein receptors: structure, function and targeting by selective small molecule kinase inhibitors, Bone 138.
- Feen, D.E. van der; Bossers, G.P.L.; Hagdorn, Q.A.J.; Moonen, J.R.; Kurakula, K.; Szulcek, R.; Chappell, J.; Vallania, F.; Donato, M.; Kok, K.; Kohli, J.S.; Petersen, A.H.; Leusden, T. van; Demaria, M.; Goumans, M.J.T.H.; Boer, R.A. de; Khatri, P.; Rabinovitch, M.; Berger, R.M.F. & Bartelds, B. (2020), Cellular senescence impairs the reversibility of pulmonary arterial hypertension, Science Translational Medicine 12(554).
- Peterson, J.C.; Wisse, L.J.; Wirokromo, V.; Herwaarden, T. van; Smits, A.M.; Groot, A.C.G.; Goumans, M.J.T.H.; VanMunsteren, J.C.; Jongbloed, M.R.M. & DeRuiter, M.C. (2020), Disturbed nitric oxide signalling gives rise to congenital bicuspid aortic valve and aortopathy, Disease Models and Mechanisms 13(9).
- Dronkers, E.; Herwaarden, T. van; Goumans, M.J. & Smits, A.M. (2020), A small molecule screen identifies novel inducers of EMT that may increase epicardium-driven repair of the heart, European Heart Journal 41: 3651-3651.
- Vries, M.R. de; Parma, L.; Peters, H.A.B.; Schepers, A.; Hamming, J.F.; Jukema, J.W.; Goumans, M.J.T.H.; Guo, L.; Finn, A.V.; Virmani, R.; Ozaki, C.K. & Quax, P.H.A. (2019), Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels, Journal of Internal Medicine 285(1): 59-74.
- Nikolic, I.; Yung, L.M.; Yang, P.R.; Malhotra, R.; Paskin-Flerlage, S.D.; Dinter, T.; Bocobo, G.A.; Tumelty, K.E.; Faugno, A.J.; Troncone, L.; McNeil, M.E.; Huang, X.L.; Coser, K.R.; Lai, C.S.C.; Upton, P.D.; Goumans, M.J.; Zamanian, R.T.; Elliott, C.G.; Lee, A.; Zheng, W.; Berasi, S.P.; Huard, C.; Morrell, N.W.; Chung, R.T.; Channick, R.W.; Roberts, K.E. & Yu, P.B. (2019), Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension, American Journal of Respiratory and Critical Care Medicine 199(7): 891-902.
- Vegh, A.M.D.; Haan, A.D. den; Ortega, L.C.; Verkerk, A.O.; Sluijter, J.P.G.; Bakker, D.; Amersfoorth, S. van; Veen, T.A.B. van; Klerk, M.; Seppen, J.; Bakker, J.M.T. de; Christoffels, V.M.; Geerts, D.; Goumans, M.J.T.H.; Tan, H.L. & Boink, G.J.J. (2019), Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing, Molecules 24(1).
- Pol, V. van de; Bons, L.R.; Lodder, K.; Kurakula, K.B.; Sanchez-Duffhues, G.; Siebelink, H.M.J.; Roos-Hesselink, J.W.; DeRuiter, M.C. & Goumans, M.J. (2019), Endothelial Colony Forming Cells as an Autologous Model to Study Endothelial Dysfunction in Patients with a Bicuspid Aortic Valve, International Journal of Molecular Sciences 20(13).
- Maring, J.A.; Lodder, K.; Mol, E.; Verhage, V.; Wiesmeijer, K.C.; Dingenouts, C.K.E.; Moerkamp, A.T.; Deddens, J.C.; Vader, P.; Smits, A.M.; Sluijter, J.P.G. & Goumans, M.J. (2019), Cardiac Progenitor Cell-Derived Extracellular Vesicles Reduce Infarct Size and Associate with Increased Cardiovascular Cell Proliferation, Journal of Cardiovascular Translational Research 12(1): 5-17.
- Ge, Y.; Smits, A.M.; Munsteren, J.C. van; Herwaarden, T. van; Vegh, A.M.D.; Goumans, M.J.T.H.; Schalij, M.J.; Ruiter, M.C. de & Jongbloed, M.R.M. (2019), Epicardium derived cells promote sympathetic ganglionic outgrowth towards myocardium in vitro, European Heart Journal 40: 3280-3280.
- Sanchez-Duffhues, G.; Mikkers, H.; Jong, D. de; Szuhai, K.; Vries, T.J. de; Freund, C.; Bravenboer, N.; Es, R.J.J. van; Netelenbos, J.C.; Goumans, M.J.; Eekhoff, E.M.W. & Dijke, P. ten (2019), Generation of Fibrodysplasia ossificans progressiva and control integration free iPSC lines from periodontal ligament fibroblasts, Stem Cell Research 41.
- Smits, A.M.; Vegh, A.M.D.; Herwaarden, T. van; Dronkers, E.; Moerkamp, A.T.; Lodder, K. & Goumans, M.J. (2019), Harnessing epicardial-derived cells for myocardial repair: the importance of epithelial-to-mesenchymal transition, European Heart Journal 40: 3910-3910.
- Ouwerkerk, A.F. van; Bosada, F.M.; Duijvenboden, K. van; Hill, M.C.; Montefiori, L.E.; Scholman, K.T.; Liu, J.; Vries, A.A.F. de; Boukens, B.J.; Ellinor, P.T.; Goumans, M.J.T.H.; Efimov, I.R.; Nobrega, M.A.; Barnett, P.; Martin, J.F. & Christoffels, V.M. (2019), Identification of atrial fibrillation associated genes and functional non-coding variants, Nature Communications 10.
- Bax, N.A.M.; Duim, S.N.; Kruithof, B.P.T.; Smits, A.M.; Bouten, C.V.C. & Goumans, M.J. (2019), In vivo and in vitro Approaches Reveal Novel Insight Into the Ability of Epicardium-Derived Cells to Create Their Own Extracellular Environment, Frontiers in Cardiovascular Medicine 6.
- Feen, D.E. van der; Kurakula, K.; Tremblay, E.; Boucherat, O.; Bossers, G.P.L.; Szulcek, R.; Bourgeois, A.; Lampron, M.C.; Habbout, K.; Martineau, S.; Paulin, R.; Kulikowski, E.; Jahagirdar, R.; Schalij, I.; Bogaard, H.J.; Barteld, B.; Provencher, S.; Berger, R.M.F.; Bonnet, S. & Goumans, M.J. (2019), Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension, American Journal of Respiratory and Critical Care Medicine 200(7): 910-920.
- Pol, V. van de; Bons, L.R.; Lodder, K.; Kurakula, K.B.; Sanchez-Duffhues, G.; Siebelink, H.M.J.; Roos-Hesselink, J.W.; DeRuiter, M.C. & Goumans, M.J. (2019), Endothelial colony forming cells as an autologous model to study endothelial dysfunction in patients with a bicuspid aortic valve, International Journal of Molecular Sciences.
- Rol, N.; Raaf, M.A. de; Sun, X.Q.Q.; Kuiper, V.P.; Bos, D.D.G.; Happe, C.; Kurakula, K.; Dickhoff, C.; Thuillet, R.; Tu, L.; Guignabert, C.; Schalij, I.; Lodder, K.; Pan, X.K.; Herrmann, F.E.; Amerongen, G.P.V.; Koolwijk, P.; Vonk-Noordegraaf, A.; Man, F.S. de; Wollin, L.; Goumans, M.J.; Szulcek, R. & Bogaard, H.J. (2019), Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension, Cardiovascular Research 115(2): 432-439.
- Cozijnsen, L.; Plomp, A.S.; Post, J.G.; Pals, G.; Bogunovic, N.; Yeung, K.K.; Niessen, H.W.M.; Goumans, M.J.T.H.; Barge-Schaapveld, D.Q.C.M. & Micha, D. (2019), Pathogenic effect of a TGFBR1 mutation in a family with Loeys-Dietz syndrome, Molecular Genetics and Genomic Medicine 7(10).
- Turaihi AH, Serne EH, Molthoff C, Koning JJ, Niessen HW, Goumans MJTH, Jimenez CJ, Van Poelgeest EM, Yudkin JS, Smulders YM, van Hinsbergh VWM & Eringa EC (2019), Perivascular adipose tissue controls vasodilatation and tissue perfusion in vivo, Acta Ophthalmologica 97: 11-11.
- Balbi, C.; Lodder, K.; Costa, A.; Moimas, S.; Moccia, F.; Herwaarden, T. van; Rosti, V.; Campagnoli, F.; Palmeri, A.; Biasio, P. de; Santini, F.; Giacca, M.; Goumans, M.J.; Barile, L.; Smits, A.M. & Bollini, S. (2019), Reactivating endogenous mechanisms of cardiac regeneration via paracrine boosting using the human amniotic fluid stem cell secretome, International Journal of Cardiology 287: 87-95.
- Kurakula, K.; Boucherat, O.; Feen, D.E. van der; Bogaard, H.J.; Kulikowski, E.; Bartelds, B.; Provencher, S.; Berger, R.M.F.; Bonnet, S. & Goumans, M.J. (2019), Reply to Piquereau and Perros and to Pullamsetti and de Jesus Perez.
- Balbi, C.; Lodder, K.; Costa, A.; Moimas, S.; Moccia, F.; Herwaarden, T. van; Rosti, V.; Campagnoli, F.; Palmeri, A.; Biasio, P. de; Santini, F.; Giacca, M.; Goumans, M.J.; Barile, L.; Smits, A.M. & Bollini, S. (2019), Supporting data on in vitro cardioprotective and proliferative paracrine effects by the human amniotic fluid stem cell secretome, Data in Brief 25.
- Grewal, N.; Girdauskas, E.; DeRuiter, M.; Goumans, M.J.; Poelmann, R.E.; Klautz, R.J.M. & Gittenberger-de Groot, A.C. (2019), The role of hemodynamics in bicuspid aortopathy: a histopathologic study, Cardiovascular Pathology 41: 29-37.
- Gomez-Puerto, M.C.; Zuijen, I. van; Huang, C.J.Z.; Szulcek, R.; Pan, X.K.; Dinther, M.A.H. van; Kurakula, K.; Wiesmeijer, C.C.; Goumans, M.J.; Bogaard, H.J.; Morrell, N.W.; Rana, A.A. & Dijke, P. ten (2019), Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension, Journal of Pathology 249(3): 356-367.
- Sanchez-Duffhues, G.; Vinuesa, A.G. de; Pol, V. van de; Geerts, M.E.; Vries, M.R. de; Janson, S.G.T.; Dam, H. van; Lindeman, J.H.; Goumans, M.J. & Dijke, P. ten (2019), Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2, Journal of Pathology 247(3): 333-346.
- Quinn, P.M.; Buck, T.M.; Mulder, A.A.; Ohonin, C.; Alves, C.H.; Vos, R.M.; Bialecka, M.; Herwaarden, T. van; Dijk, E.H.C. van; Talib, M.; Freund, C.; Mikkers, H.M.M.; Hoeben, R.C.; Goumans, M.J.; Boon, C.J.F.; Koster, A.J.; Lopes, S.M.C.D.; Jost, C.R. & Wijnholds, J. (2019), Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Muller Glia Are Targets of AAV5, Stem Cell Reports 12(5): 906-919.
- Kurakula, K.; Sun, X.Q.; Happe, C.; Bos, D.D.G.; Szulcek, R.; Schalij, I.; Wiesmeijer, K.C.; Lodder, K.; Tu, L.; Guignabert, C.; Vries, C.J.M. de; Man, F.S. de; Noordegraaf, A.V.; Dijke, P. ten; Goumans, M.J. & Bogaard, H.J. (2019), Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling, European Respiratory Journal 54(3).
- Mol, E.A.; Lei, Z.Y.; Roefs, M.T.; Bakker, M.H.; Goumans, M.J.; Doevendans, P.A.; Dankers, P.Y.W.; Vader, P. & Sluijter, J.P.G. (2019), Injectable Supramolecular Ureidopyrimidinone Hydrogels Provide Sustained Release of Extracellular Vesicle Therapeutics, Advanced Healthcare Materials 8(20).
- Dronkers, E.; Herwaarden, T. van; Goumans, M.J. & Smits, A.M. (2018), High throughput screen to identify EMT-inducing compounds in human epicardial cells, Cardiovascular Research 114: S72-S73.
- Kurakula, K.B.; Sun, X.; Happe, C.; Goumans, M.J. & Bogaard, H.J. (2018), Pharmacological activation of nuclear receptor Nur77 decreases endothelial cell dysfunction and reduces experimental pulmonary hypertension, Cardiovascular Research 114: S139-S140.
- Kurakula, K.B.; Sun, X.Q.; Happe, C.; Goumans, M.J. & Bogaard, H.J. (2018), Pharmacological activation of Nur77 enhances BMP signalling and inhibits vascular remodelling in pulmonary arterial hypertension, European Respiratory Journal 52.
- Mol, E.; Lei, Z.; Bakker, M.H.; Vader, P.; Schiffelers, R.M.; Dankers, P.Y.W.; Chamuleau, S.A.J.; Doevendans, P.A.; Goumans, M.J. & Sluijter, J.P. (2018), Slow release of cardiac progenitor cell-derived extracellular vesicles from a pH-switchable hydrogel, Cardiovascular Research 114: S53-S53.
- Kurakula, K.; Koenis, D.S.; Herzik, M.A.; Liu, Y.Y.; Craft, J.W.; Loenen, P.B. van; Vos, M.; Tran, M.K.; Versteeg, H.H.; Goumans, M.J.T.H.; Ruf, W.; Vries, C.J.M. de & Sen, M. (2018), Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity, Haematologica 103(6): 1073-1082.
- Moursel, L.G.; Munting, L.P.; Graaf, L.M. van der; Duinen, S.G. van; Goumans, M.J.T.H.; Ueberham, U.; Natte, R.; Buchem, M.A. van; Roon-Mom, W.M.C. van & Weerd, L. van der (2018), TGF beta pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type, Brain Pathology 28(4): 495-506.
- Balbi, C.; Barile, L.; Moimas, S.; Moccia, F.; Smits, A.; Santini, F.; Coviello, D.; Goumans, M.J.; Giacca, M. & Bollini, S. (2018), The human amniotic fluid stem cell secretome as new paracrine source to unlock endogenous cardiac regeneration, Vascular Pharmacology 103: 47-48.
- Balbi, C.; Lodder, K.; Moimas, S.; Moccia, F.; Rosti, V.; Herwaarden, T. van; Giacca, M.; Goumans, M.J.; Smits, A.M. & Bollini, S. (2018), The human amniotic fluid stem cell secretome as new promising tool to restore cardiac regeneration by paracrine therapy, Cardiovascular Research 114: S28-S28.
- Wesseling, M.; Sakkers, T.R.; Jager, S.C.A. de; Pasterkamp, G. & Goumans, M.J. (2018), The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis, Vascular Pharmacology 106: 1-8.
- Dronkers, E.; Moerkamp, A.T.; Herwaarden, T. van; Goumans, M.J. & Smits, A.M. (2018), The Isolation and Culture of Primary Epicardial Cells Derived from Human Adult and Fetal Heart Specimens, Journal of Visualized Experiments.
- Smits, A.M.; Dronkers, E. & Goumans, M.J. (2018), The epicardium as a source of multipotent adult cardiac progenitor cells: Their origin, role and fate, Pharmacological Research 127: 129-140.
- Goumans, M.J. & Dijke, P. ten (2018), TGF-beta Signaling in Control of Cardiovascular Function, Cold Spring Harbor perspectives in biology 10(2).
- Moursel, L.G.; Munting, L.P.; Graaf, L.M. van der; Duinen, S.G. van; Goumans, M.J.T.H.; Ueberham, U.; Natte, R.; Buchem, M.A. van; Roon-Mom, W.M.C. van & Weerd, L. van der (2018), TGF beta pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type, Brain Pathology 28(4): 495-506.
- Rol, N.; Kurakula, K.B.; Happe, C.; Bogaard, H.J. & Goumans, M.J. (2018), TGF-beta and BMPR2 Signaling in PAH: Two Black Sheep in One Family, International Journal of Molecular Sciences 19(9).
- Kurakula, K.; Koenis, D.S.; Herzik, M.A.; Liu, Y.Y.; Craft, J.W.; Loenen, P.B. van; Vos, M.; Tran, M.K.; Versteeg, H.H.; Goumans, M.J.T.H.; Ruf, W.; Vries, C.J.M. de & Sen, M. (2018), Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity, Haematologica 103(6): 1073-1082.
- Vorselaars, V.M.M.; Hosman, A.E.; Westermann, C.J.J.; Snijder, R.J.; Mager, J.J.; Goumans, M.J. & Post, M.C. (2018), Pulmonary Arterial Hypertension and Hereditary Haemorrhagic Telangiectasia, International Journal of Molecular Sciences 19(10).
- Verjans, R.; Peters, T.; Beaumont, F.J.; Leeuwen, R. van; Herwaarden, T. van; Verhesen, W.; Munts, C.; Bijnen, M.; Henkens, M.; Diez, J.; Windt, L.J. de; Nieuwenhoven, F.A. van; Bilsen, M. van; Goumans, M.J.; Heymans, S.; Gonzalez, A. & Schroen, B. (2018), MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure, Hypertension 71(2): 280-288.
- Dummer, A.; Rol, N.; Szulcek, R.; Kurakula, K.; Pan, X.K.; Visser, B.I.; Bogaard, H.J.; DeRuiter, M.C.; Goumans, M.J. & Hierck, B.P. (2018), Endothelial dysfunction in pulmonary arterial hypertension: loss of cilia length regulation upon cytokine stimulation, Pulmonary Circulation 8(2).
- Bos, D.D.G.; Bruggen, C.E.E. van der; Kurakula, K.; Sun, X.Q.; Casali, K.R.; Casali, A.G.; Rol, N.; Szulcek, R.; Remedios, C. dos; Guignabert, C.; Tu, L.; Dorfmuller, P.; Humbert, M.; Wijnker, P.J.M.; Kuster, D.W.D.; Velden, J. van der; Goumans, M.J.; Bogaard, H.J.; Vonk-Noordegraaf, A.; Man, F.S. de & Handoko, M.L. (2018), Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Circulation 137(9): 910-924.
- Goumans, M.J.; Zwijsen, A.; Dijke, P. ten & Bailly, S. (2018), Bone Morphogenetic Proteins in Vascular Homeostasis and Disease, Cold Spring Harbor perspectives in biology 10(2).
- Peterson, J.C.; Chughtai, M.; Wisse, L.J.; Gittenberger-de Groot, A.C.; Feng, Q.P.; Goumans, M.J.T.H.; VanMunsteren, J.C.; Jongbloed, M.R.M. & DeRuiter, M.C. (2018), Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart field, Disease Models and Mechanisms 11(10).
- Boas, S.E.M.; Carvalhol, J.; Broek, M. van den; Weijers, E.M.; Goumans, M.J.; Koolwijk, P. & Merks, R.M.H. (2018), A local uPAR-plasmin-TGF beta 1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants, PLoS Computational Biology 14(7).
- Ellenbroek, G.H.J.M.; Haan, J.J. de; Klarenbosch, B.R. van; Brans, M.A.D.; Weg, S.M.V. de; Smeets, M.B.; Jong, S. de; Arslan, F.; Timmers, L.; Goumans, M.J.T.H.; Hoefer, I.E.; Doevendans, P.A.; Pasterkamp, G.; Meyaard, L. & Jager, S.C.A. de (2017), Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice, Scientific Reports 7.
- Bao, X.P.; Lian, X.J.; Hacker, T.A.; Schmuck, E.G.; Qian, T.C.; Bhute, V.J.; Han, T.X.; Shi, M.X.; Drowley, L.; Plowright, A.T.; Wang, Q.D.; Goumans, M.J. & Palecek, S.P. (2017), Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions, Nature Biomedical Engineering 1(1).
- Spreeuwel, A.C.C. van; Bax, N.A.M.; Nierop, B.J. van; Aartsma-Rus, A.; Goumans, M.J.T.H. & Bouten, C.V.C. (2017), Mimicking Cardiac Fibrosis in a Dish: Fibroblast Density Rather than Collagen Density Weakens Cardiomyocyte Function, Journal of Cardiovascular Translational Research 10(2): 116-127.
- Paunovic, A.I.; Drowley, L.; Nordqvist, A.; Ericson, E.; Mouchet, E.; Jonebring, A.; Gronberg, G.; Kvist, A.J.; Engkvist, O.; Brown, M.R.; Gedda, K.; Goumans, M.J.; Wang, Q.D. & Plowright, A.T. (2017), Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts, ACS Chemical Biology 12(1): 132-141.
- Jager, S.C.A. de; Meeuwsen, J.A.L.; Pijpen, F.M. van; Zoet, G.A.; Barendrecht, A.D.; Franx, A.; Pasterkamp, G.; Rijn, B.B. van; Goumans, M.J. & Ruijter, H.M. den (2017), Preeclampsia and coronary plaque erosion: Manifestations of endothelial dysfunction resulting in cardiovascular events in women, European Journal of Pharmacology 816: 129-137.
- Mauretti, A.; Rossi, F.; Bax, N.A.M.; Miano, C.; Miraldi, F.; Goumans, M.J.; Messina, E.; Giacomello, A.; Bouten, C.V.C. & Sahlgren, C. (2017), Spheroid three-dimensional culture enhances Notch signaling in cardiac progenitor cells, MRS Communications 7(3): 496-501.
- Caam, A. van; Madej, W.; Vinuesa, A.G. de; Goumans, M.J.; Dijke, P. ten; Davidson, E.B. & Kraan, P. van der (2017), TGF beta 1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity, Arthritis Research and Therapy 19.
- Pasterkamp, G. & Goumans, M.J. (2017), The Microvasculature The Next Battlefield Where Transforming Growth Factor-beta and Endoglin Draw Their Double-Edged Swords?, Arteriosclerosis, Thrombosis, and Vascular Biology 37(1): 10-12.
- Breitkopf-Heinlein, K.; Meyer, C.; Konig, C.; Gaitantzi, H.; Addante, A.; Thomas, M.; Wiercinska, E.; Cai, C.; Li, Q.; Wan, F.Q.; Hellerbrand, C.; Valous, N.A.; Hahnel, M.J.; Ehlting, C.; Bode, J.G.; Mueller-Bohl, S.; Klingmuller, U.; Altenoder, J.; Ilkavets, I.; Goumans, M.J.; Hawinkels, L.J.A.C.; Lee, S.J.; Wieland, M.; Mogler, C.; Ebert, M.P.; Herrera, B.; Augustin, H.G.; Sanchez, A.; Dooley, S. & Dijke, P. ten (2017), BMP-9 interferes with liver regeneration and promotes liver fibrosis, Gut 66(5): 939-954.
- Chen, X.; Orriols, M.; Walther, F.J.; Laghmani, E.H.; Hoogeboom, A.M.; Hogen-Esch, A.C.B.; Hiemstra, P.S.; Folkerts, G.; Goumans, M.J.T.H.; Dijke, P. ten; Morrell, N.W. & Wagenaar, G.T.M. (2017), Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation, Frontiers in Physiology 8.
- Chen, X.; Orriols, M.; Laghmani, E.; Hoogeboom, A.; Hogen-Esch, A.; Hiemstra, P.; Folkerts, G.; Goumans, M.J.; Dijke, P.; Morrell, N.; Walther, F. & Wagenaar, G. (2017), Bone Morphogenetic Protein 9 Protects Against Neonatal Hyperoxia-Induced Lung Injury By Improving Alveolarization And Reducing Pulmonary Inflammation, American Journal of Respiratory and Critical Care Medicine 195.
- Tiburcy, M.; Hudson, J.E.; Balfanz, P.; Schlick, S.; Meyer, T.; Liao, M.L.C.; Levent, E.; Raad, F.; Zeidler, S.; Wingender, E.; Riegler, J.; Wang, M.; Gold, J.D.; Kehat, I.; Wettwer, E.; Ravens, U.; Dierickx, P.; Laake, L.W. van; Goumans, M.J.; Khadjeh, S.; Toischer, K.; Hasenfuss, G.; Couture, L.A.; Unger, A.; Linke, W.A.; Araki, T.; Neel, B.; Keller, G.; Gepstein, L.; Wu, J.C. & Zimmermann, W.H. (2017), Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair, Circulation 135(19): 1832-+.
- Moerkamp, A.T.; Leung, H.W.; Bax, N.A.M.; Holst, S.; Lodder, K.; Berends, T.; Dingenouts, C.K.E.; Choo, A.; Smits, A.M. & Goumans, M.J. (2017), Glycosylated Cell Surface Markers for the Isolation of Human Cardiac Progenitors, Stem Cells and Development 26(21): 1552-1565.
- Mol, E.A.; Goumans, M.J.; Doevendans, P.A.; Sluijter, J.P.G. & Vader, P. (2017), Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation, Nanomedicine: Nanotechnology, Biology and Medicine 13(6): 2061-2065.
- Dingenouts, C.K.E.; Bakker, W.; Lodder, K.; Wiesmeijer, K.C.; Moerkamp, A.T.; Maring, J.A.; Arthur, H.M.; Smits, A.M. & Goumans, M.J. (2017), Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction, PLoS ONE 12(12).
- Moerkamp, A.T.; Leung, H.W.; Bax, N.A.M.; Holst, S.; Lodder, K.; Berends, T.; Dingenouts, C.K.E.; Choo, A.; Smits, A.M. & Goumans, M.J. (2017), Glycosylated cell surface markers for the isolation of human cardiac progenitors., Stem Cells and Development.
- Mol, E.A.; Goumans, M.J.; Sluijter, J.P.G.; Xiao, J. & Cretoiu, S. (2017), Cardiac Progenitor-Cell Derived Exosomes as Cell-Free Therapeutic for Cardiac Repair.
- Mol, E.A.; Goumans, M.J.; Doevendans, P.A.; Sluijter, J.P.G. & Vader, P. (2017), Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation.
- Pol, V.V. de; Kurakula, K.; DeRuiter, M.C. & Goumans, M.J. (2017), Thoracic aortic aneurysm development in patients with bicuspid aortic valve: what is the role of endothelial cells?, Frontiers in Physiology.
- Zwetsloot, Peter Paul Végh, Anna Maria Dorothea Jansen Of Lorkeers, Sanne Johanna van Hout, Gerardus P J Currie, Gillian L Sena, Emily S Gremmels, Hendrik Buikema, Jan Willem Goumans, Marie-Jose Macleod, Malcolm R Doevendans, Pieter a Chamuleau, Steven A J Sluijter & Joost P G (2016), Cardiac Stem Cell Treatment in Myocardial Infarction: A Systematic Review and Meta-Analysis of Preclinical Studies., Circulation Research 118(8).
- Hawinkels, L.J.A.C.; Vinuesa, A.G. de; Paauwe, M.; Kruithof-de Julio, M.; Wiercinska, E.; Pardali, E.; Mezzanotte, L.; Keereweer, S.; Braumuller, T.M.; Heijkants, R.C.; Jonkers, J.; Lowik, C.W.; Goumans, M.J.; Hagen, T.L. ten & Dijke, P. ten (2016), Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors, Clinical Cancer Research 22(1): 96-106.
- Caam, A. van; Madej, W.; Thijssen, E.; Vinuesa, A.G. de; Berg, W. van den; Goumans, M.J.; Dijke, P. ten; Davidson, E.B. & Kraan, P.M. van der (2016), Expression of TGF beta-family signalling components in ageing cartilage: age-related loss of TGF beta and BMP receptors, Osteoarthritis and Cartilage 24(7): 1235-1245.
- Karkampouna, S.; Goumans, M.J.; Dijke, P. ten; Dooley, S. & Kruithof-de Julio, M. (2016), Inhibition of TGF beta type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice, Archives of Toxicology 90(2): 347-357.
- Morrell, N.W.; Bloch, D.B.; Dijke, P. ten; Goumans, M.J.T.H.; Hata, A.; Smith, J.; Yu, P.B. & Bloch, K.D. (2016), Targeting BMP signalling in cardiovascular disease and anaemia, Nature Reviews Cardiology 13(2): 106-120.
- Ribeiro, M.C.; Tertoolen, L.G.; Guadix, J.A.; Bellin, M.; Kosmidis, G.; D'Aniello, C.; Monshouwer-Kloots, J.; Goumans, M.J.; Wang, Y.L.; Feinberg, A.W.; Mummery, C.L. & Passier, R. (2015), Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro - Correlation between contraction force and electrophysiology, Biomaterials 51: 138-150.
- Leung, H.W.; Moerkamp, A.T.; Padmanabhan, J.; Ng, S.W.; Goumans, M.J. & Choo, A. (2015), mAb C19 targets a novel surface marker for the isolation of human cardiac progenitor cells from human heart tissue and differentiated hESCs, Journal of Molecular and Cellular Cardiology 82.
- Dingenouts CKE & Goumans M-J and Bakker W (2015), Mononuclear cells and vascular repair in HHT, Frontiers in Genetics 6(114).
- Bertoli-Avella, A.M.; Gillis, E.; Morisaki, H.; Verhagen, J.M.A.; Graaf, B.M. de; Beek, G. van de; Gallo, E.; Kruithof, B.P.T.; Venselaar, H.; Myers, L.A.; Laga, S.; Doyle, A.J.; Oswald, G.; Cappellen, G.W.A. van; Yamanaka, I.; Helm, R.M. van der; Beverloo, B.; Klein, A. de; Pardo, L.; Lammens, M.; Evers, C.; Devriendt, K.; Dumoulein, M.; Timmermans, J.; Bruggenwirth, H.T.; Verheijen, F.; Rodrigus, I.; Baynam, G.; Kempers, M.; Saenen, J.; Craenenbroeck, E.M. van; Minatoya, K.; Matsukawa, R.; Tsukube, T.; Kubo, N.; Hofstra, R.; Goumans, M.J.; Bekkers, J.A.; Roos-Hesselink, J.W.; Laar, I.M.B.H. van de; Dietz, H.C.; Laer, L. van; Morisaki, T.; Wessels, M.W. & Loeys, B.L. (2015), Mutations in a TGF-beta Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections, Journal of the American College of Cardiology 65(13): 1324-1336.
- Leung, H.W.; Moerkamp, A.T.; Padmanabhan, J.; Ng, S.W.; Goumans, M.J. & Choo, A. (2015), mAb C19 targets a novel surface marker for the isolation of human cardiac progenitor cells from human heart tissue and differentiated hESCs, Journal of Molecular and Cellular Cardiology 82: 228-237.
- Marion, M.H. van; Bax, N.A.M.; Turnhout, M.C. van; Mauretti, A.; Schaft, D.W.J. van der; Goumans, M.J.T.H. & Bouten, C.V.C. (2015), Behavior of CMPCs in unidirectional constrained and stress-free 3D hydrogels, Journal of Molecular and Cellular Cardiology 87: 79-91.
- Clunie-O'Connor C, Smits AM, Antoniades C, Russell AJ, Yellon DM, Goumans MJ & Riley PR. (2015), The Derivation of Primary Human Epicardium-Derived Cells.
- Duim, S.N.; Kurakula, K.; Goumans, M.J. & Kruithof, B.P.T. (2015), Cardiac endothelial cells express Wilms' tumor-1 Wt1 expression in the developing, adult and infarcted heart, Journal of Molecular and Cellular Cardiology 81: 127-135.
- P. P. Zwetsloot, S. J. Jansen of Lorkeers, A. M. D. Végh, G. P. J. van Hout, G. L. Currie, M. J. Goumans & S. A. J. Chamuleau andJ. P. G. Sluijter (2015), Cardiac stem cell treatment in myocardial infarction: protocol for a systematic review and meta-analysis of preclinical studies, Evidence-based Preclinical Medicine.
- Kelder, T.P.; Duim, S.N.; Vicente-Steijn, R.; Vegh, A.M.D.; Kruithof, B.P.T.; Smits, A.M.; Bavel, T.C. van; Bax, N.A.M.; Schalij, M.J.; Gittenberger-de Groot, A.C.; DeRuiter, M.C.; Goumans, M.J. & Jongbloed, M.R.M. (2015), The epicardium as modulator of the cardiac autonomic response during early development, Journal of Molecular and Cellular Cardiology 89: 251-259.
- Caam, A. van; Davidson, E.B.; Vinuesa, A.G. de; Geffen, E. van; Berg, W. van den; Goumans, M.J.; Dijke, P. ten & Kraan, P. van der (2015), The high affinity ALK1-ligand BMP9 induces a hypertrophy-like state in chondrocytes that is antagonized by TGF beta 1, Osteoarthritis and Cartilage 23(6): 985-995.
- Sanchez-Duffhues, G.; Vinuesa, A.G. de; Lindeman, J.H.; Mulder-Stapel, A.; DeRuiter, M.C.; Munsteren, C. van; Goumans, M.J.; Hierck, B.P. & Dijke, P. ten (2015), SLUG Is Expressed in Endothelial Cells Lacking Primary Cilia to Promote Cellular Calcification, Arteriosclerosis, Thrombosis, and Vascular Biology 35(3): 616-627.
- Kurakula, K.; Goumans, M.J. & Dijke, P. ten (2015), REGULATORY RNAs CONTROLLING VASCULAR (DYS)FUNCTION BY AFFECTING TGF-beta FAMILY SIGNALLING, EXCLI Journal : Experimental and Clinical Sciences 14: 832-850.
- Vicente-Steijn, R.; Scherptong, R.W.C.; Kruithof, B.P.T.; Duim, S.N.; Goumans, M.J.T.H.; Wisse, L.J.; Zhou, B.; Pu, W.T.; Poelmann, R.E.; Schalij, M.J.; Tallquist, M.D.; Gittenberger-de Groot, A.C. & Jongbloed, M.R.M. (2015), Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction.
- Kruithof, B.P.T.; Lieber, S.C.; Kruithof-de Julio, M.; Gaussin, V. & Goumans, M.J. (2015), Culturing Mouse Cardiac Valves in the Miniature Tissue Culture System, Journal of Visualized Experiments.
- Jansen Lorkeers, S.J.; Gho, J.M.I.H.; Koudstaal, S.; Hout, G.P.J. van; Zwetsloot, P.P.M.; Oorschot, J.W.M. van; Eeuwijk, E.C.M. van; Leiner, T.; Hoefer, I.E.; Goumans, M.J.; Doevendans, P.A.; Sluijter, J.P.G. & Chamuleau, S.A.J. (2015), Xenotransplantation of Human Cardiomyocyte Progenitor Cells Does Not Improve Cardiac Function in a Porcine Model of Chronic Ischemic Heart Failure. Results from a Randomized, Blinded, Placebo Controlled Trial.
- Tijsen, A.J.; Made, I. van der; Hoogenhof, M.M. van den; Wijnen, W.J.; Deel, E.D. van; Groot, N.E. de; Alekseev, S.; Fluiter, K.; Schroen, B.; Goumans, M.J.; Velden, J. van der; Duncker, D.J.; Pinto, Y.M. & Creemers, E.E. (2014), The microRNA-15 family inhibits the TGF beta-pathway in the heart, Cardiovascular Research 104(1): 61-71.
- Grewal, N.; Gittenberger-de Groot, A.C.; Poelmann, R.E.; Klautz, R.J.M.; Lindeman, J.H.N.; Goumans, M.J.; Palmen, M.; Mohamed, S.A.; Sievers, H.H.; Bogers, A.J.J.C. & DeRuiter, M.C. (2014), Ascending aorta dilation in association with bicuspid aortic valve: A maturation defect of the aortic wall, Journal of Thoracic and Cardiovascular Surgery 148(4): 1583-1590.
- Grewal, N.; Gittenberger-de Groot, A.C.; DeRuiter, M.C.; Klautz, R.J.M.; Poelmann, R.E.; Duim, S.; Lindeman, J.H.N.; Koenraadt, W.M.C.; Jongbloed, M.R.M.; Mohamed, S.A.; Sievers, H.H.; Bogers, A.J.J.C. & Goumans, M.J. (2014), Bicuspid aortic valve: phosphorylation of c-Kit and downstream targets are prognostic for future aortopathy, European Journal of Cardio-Thoracic Surgery 46(5): 831-839.
- Pagliari, S.; Tirella, A.; Ahluwalia, A.; Duim, S.; Goumans, M.J.; Aoyagi, T. & Forte, G. (2014), A multistep procedure to prepare pre-vascularized cardiac tissue constructs using adult stem sells, dynamic cell cultures, and porous scaffolds, Frontiers in Physiology 5.
- Karkampouna, S.; Kruithof, B.P.T.; Kloen, P.; Obdeijn, M.C.; Laan, A.M.A. van der; Tanke, H.J.; Kemaladewi, D.U.; Hoogaars, W.M.H.; Hoen, P.A.C. 't; Aartsma-Rus, A.; Clark, I.M.; Dijke, P. ten; Goumans, M.J. & Kruithof-de Julio, M. (2014), Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGF beta Type 1 Receptor Modulation by Antisense Oligonucleotides, Molecular Therapy - Nucleic Acids 3.
- Liu, Z.; Lebrin, F.; Maring, J.A.; Driesche, S. van den; Brink, S. van der; Dinther, M. van; Thorikay, M.; Martin, S.; Kobayashi, K.; Hawinkels, L.J.A.C.; Meeteren, L.A. van; Pardali, E.; Korving, J.; Letarte, M.; Arthur, H.M.; Theuer, C.; Goumans, M.J.; Mummery, C. & Dijke, P. ten (2014), ENDOGLIN Is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-Induced Angiogenesis, PLoS ONE 9(1).
- Goumans, M.J.; Maring, J.A. & Smits, A.M. (2014), A straightforward guide to the basic science behind cardiovascular cell-based therapies, Heart 100(15): 1153-1157.
- Grewal, N.; DeRuiter, M.C.; Jongbloed, M.R.M.; Goumans, M.J.; Klautz, R.J.M.; Poelmann, R.E. & Gittenberger-de Groot, A.C. (2014), Normal and abnormal development of the aortic wall and valve: correlation with clinical entities, Netherlands Heart Journal 22(9): 363-369.
- Mosqueira, D.; Pagliari, S.; Uto, K.; Ebara, M.; Romanazzo, S.; Escobedo-Lucea, C.; Nakanishi, J.; Taniguchi, A.; Franzese, O.; Nardo, P. di; Goumans, M.J.; Traversa, E.; Pinto-do-O, P.; Aoyagi, T. & Forte, G. (2014), Hippo Pathway Effectors Control Cardiac Progenitor Cell Fate by Acting as Dynamic Sensors of Substrate Mechanics and Nanostructure, ACS Nano 8(3): 2033-2047.
- Zhou, F.F.; Drabsch, Y.; Dekker, T.J.A.; Vinuesa, A.G. de; Li, Y.H.; Hawinkels, L.J.A.C.; Sheppard, K.A.; Goumans, M.J.; Luwor, R.B.; Vries, C.J. de; Mesker, W.E.; Tollenaar, R.A.E.M.; Devilee, P.; Lu, C.X.; Zhu, H.J.; Zhang, L. & Dijke, P. ten (2014), Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-beta signalling, Nature Communications 5.
- Haverslag, R.T.; Groot, D. de; Grundmann, S.; Meder, B.; Goumans, M.J.; Pasterkamp, G.; Hoefer, I.E. & Kleijn, D.P.V. de (2013), CD26 Inhibition Enhances Perfusion Recovery in ApoE-/-Mice, Current Vascular Pharmacology 11(1): 21-28.
- Moerkamp, A.T.; Paca, A.; Goumans, M.J.; Kunath, T.; Kruithof, B.P.T. & Kruithof-de Julio, M. (2013), Extraembryonic Endoderm cells as a model of endoderm development, Development, Growth and Differentiation 55(3): 301-308.
- Teraa, M.; Sprengers, R.W.; Westerweel, P.E.; Gremmels, H.; Goumans, M.J.T.H.; Teerlink, T.; Moll, F.L.; Verhaar, M.C. & JUVENTAS Study Grp (2013), Bone Marrow Alterations and Lower Endothelial Progenitor Cell Numbers in Critical Limb Ischemia Patients, PLoS ONE 8(1).
- Anderberg, C.; Cunha, S.I.; Zhai, Z.H.; Cortez, E.; Pardali, E.; Johnson, J.R.; Franco, M.; Paez-Ribes, M.; Cordiner, R.; Fuxe, J.; Johansson, B.R.; Goumans, M.J.; Casanovas, O.; Dijke, P. ten; Arthur, H.M. & Pietras, K. (2013), Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination.
- Mil, A. van; Vrijsen, K.R.; Goumans, M.J.; Metz, C.H.; Doevendans, P.A. & Sluijter, J.P. (2013), microRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells, Journal of Molecular Medicine 91(8): 1001-1012.
- Veer, E.P. van der; Bruin, R.G. de; Kraaijeveld, A.O.; Vries, M.R. de; Bot, I.; Pera, T.; Segers, F.M.; Trompet, S.; Gils, J.M. van; Roeten, M.K.; Beckers, C.M.; Santbrink, P.J. van; Janssen, A.; Solingen, C. van; Swildens, J.; Boer, H.C. de; Peters, E.A.; Bijkerk, R.; Rousch, M.; Doop, M.; Kuiper, J.; Schalij, M.J.; Wal, A.C. van der; Richard, S.; Berkel, T.J.C. van; Pickering, J.G.; Hiemstra, P.S.; Goumans, M.J.; Rabelink, T.J.; Vries, A.A.F. de; Quax, P.H.A.; Jukema, J.W.; Biessen, E.A.L. & Zonneveld, A.J. van (2013), Quaking, an RNA-Binding Protein, Is a Critical Regulator of Vascular Smooth Muscle Cell Phenotype, Circulation Research 113(9): 1065-1075.
- Moerkamp, A.T. & Goumans, M.J. (2012), Cardiac Regeneration: Stem Cells and Beyond, Current Medicinal Chemistry 19(35): 5993-6002.
- Kruithof, B.P.T.; Duim, S.N.; Moerkamp, A.T. & Goumans, M.J. (2012), TGFβ and BMP signaling in cardiac cushion formation: lessons from mice and chicken., Differentiation 84(1): 89-102.
- Post, S.; Broek, A.J. van den; Rensing, B.J.; Pasterkamp, G.; Goumans, M.J. & Doevendans, P.A. (2012), Reduced CD26 expression is associated with improved cardiac function after acute myocardial infarction: insights from the REPERATOR study., Journal of Molecular and Cellular Cardiology 53(6): 899-905.
- Smits AM, van Oorschot AA & Goumans MJ (2012), Isolation and differentiation of human cardiomyocyte progenitor cells into cardiomyocytes., Methods in Molecular Biology 879: 339-49.
- Gittenberger-de Groot, A.C.; Winter, E.M.; Bartelings, M.M.; Goumans, M.J.; DeReuiter, M.C. & Poelmann, R.E. (2012), The arterial and cardiac epicardium in development, disease and repair, Differentiation 84(1): -.
- Meeteren, L.A. van; Thorikay, M.; Bergqvist, S.; Pardali, E.; Stampino, C.G.; Hu-Lowe, D.; Goumans, M.J. & Dijke, P. ten (2012), Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting, Journal of Biological Chemistry 287(22): 18551-18561.
- Meeteren, L.A. van; Thorikay, M.; Bergqvist, S.; Pardali, E.; Stampino, C.G.; Hu-Lowe, D.; Goumans, M.J. & Dijke, P. ten (2012), An anti-human ALK1 antibody attenuates BMP9 induced ALK1 signaling and interferes with endothelial cell sprouting., Journal of Biological Chemistry.
- Dijke, P. ten; Egorova, A.D.; Goumans, M.J.T.H.; Poelmann, R.E. & Hierck, B.P. (2012), TGF-β signaling in endothelial-to-mesenchymal transition: the role of shear stress and primary cilia., Science Signaling 5(212): pt2.
- Post, S.; Post, M.C.; Branden, B.J. van den; Eefting, F.D.; Goumans, M.J.; Stella, P.R.; Es, H.W. van; Wildbergh, T.X.; Rensing, B.J. & Doevendans, P.A. (2012), Early statin treatment prior to primary PCI for acute myocardial infarction: REPERATOR, a randomized placebo-controlled pilot trial.
- Vliet, P. van; Goumans, M.J.; Doevendans, P.A. & Sluijter, J.P.G. (2012), Human cardiomyocyte progenitor cells: a short history of nearly everything, Journal of Cellular and Molecular Medicine 16(8): 1669-1673.
- Bax, N.A.M.; Marion, M.H. van; Shah, B.; Goumans, M.J.; Bouten, C.V.C. & Schaft, D.W.J. van der (2012), Matrix production and remodeling capacity of cardiomyocyte progenitor cells during in vitro differentiation, Journal of Molecular and Cellular Cardiology 53(4): 497-508.
- Mil, A. van; Grundmann, S.; Goumans, M.J.; Lei, Z.Y.; Oerlemans, M.I.; Jaksani, S.; Doevendans, P.A. & Sluijter, J.P. (2012), MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release, Cardiovascular Research 93(4): 655-665.
- Post, S.; Broek, A.J. van den; Rensing, B.J.; Pasterkamp, G.; Goumans, M.J. & Doevendans, P.A. (2012), Reduced CD26 expression is associated with improved cardiac function after acute myocardial infarction Insights from the REPERATOR study, Journal of Molecular and Cellular Cardiology 53(6): 899-905.
- Kruithof, B.P.T.; Duim, S.N.; Moerkamp, A.T. & Goumans, M.J. (2012), TGF beta and BMP signaling in cardiac cushion formation: Lessons from mice and chicken, Differentiation 84(1): -.
- Kraan, P.M. van der; Goumans, M.J.; Davidson, E.B. & Dijke, P. ten (2012), Age-dependent alteration of TGF-beta signalling in osteoarthritis, Cell and Tissue Research 347(1): 257-265.
- Ramkisoensing, A.A.; Pijnappels, D.A.; Swildens, J.; Goumans, M.J.; Fibbe, W.E.; Schalij, M.J.; Vries, A.A.F. de & Atsma, D.E. (2012), Gap Junctional Coupling with Cardiomyocytes is Necessary but Not Sufficient for Cardiomyogenic Differentiation of Cocultured Human Mesenchymal Stem Cells, STEM CELLS 30(6): 1236-1245.
- Haan, M.C. den; Grauss, R.W.; Smits, A.M.; Winter, E.M.; Tuyn, J. van; Pijnappels, D.A.; Steendijk, P.; Gittenberger-De Groot, A.C.; Laarse, A. van der; Fibbe, W.E.; Vries, A.A.F. de; Schalij, M.J.; Doevendans, P.A.; Goumans, M.J. & Atsma, D.E. (2012), Cardiomyogenic differentiation-independent improvement of cardiac function by human cardiomyocyte progenitor cell injection in ischaemic mouse hearts, Journal of Cellular and Molecular Medicine 16(7): 1508-1521.
- Seghers, L.; Vries, M.R. de; Pardali, E.; Hoefer, I.E.; Hierck, B.P.; Dijke, P. ten; Goumans, M.J. & Quax, P.H.A. (2012), Shear induced collateral artery growth modulated by endoglin but not by ALK1, Journal of Cellular and Molecular Medicine 16(10): 2440-2450.
- Smits AM, van Oorschot AA & Goumans MJ. (2012), Isolation and differentiation of human cardiomyocyte progenitor cells into cardiomyocytes.
- Dijke, P. ten; Egorova, A.D.; Goumans, M.J.T.H.; Poelmann, R.E. & Hierck, B.P. (2012), TGF-beta Signaling in Endothelial-to-Mesenchymal Transition: The Role of Shear Stress and Primary Cilia, Science Signaling 5(212): -.
- Bax NA, van Oorschot AA, Maas S, Braun J, van Tuyn J, de Vries AA, Groot AC & Goumans MJ (2011), In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1., Basic Research in Cardiology 106(5): 829-47.
- Bot PT, Grundmann S, Goumans MJ, de Kleijn D, Moll F, de Boer O, van der Wal AC, van Soest A, de Vries JP, van Royen N, Piek JJ, Pasterkamp G & Hoefer IE (2011), Forkhead box protein P1 as a downstream target of transforming growth factor-β induces collagen synthesis and correlates with a more stable plaque phenotype.
- van Meeteren LA, Goumans MJ & Ten Dijke P (2011), TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy., Current Pharmaceutical Biotechnology.
- Egorova, A.D.; Khedoe, P.P.S.J.; Goumans, M.J.T.H.; Nauli, S.M.; Dijke, P. ten; Poelmann, R.E. & Hierck, B.P. (2011), Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition, Circulation Research 108(9): 1093U142.
- Kraan, P.M. van der; Goumans, M.J.; Davidson, E.B. & Dijke, P. ten (2011), Age-dependent alteration of TGF-β signalling in osteoarthritis., Cell and Tissue Research.
- Egorova, A.D.; Heiden, K. van der; Pas, S. van de; Vennemann, P.; Poelma, C.; DeRuiter, M.C.; Goumans, M.J.T.H.; Gittenberger-de Groot, A.C.; Dijke, P. ten; Poelmann, R.E. & Hierck, B.P. (2011), Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells., Developmental Dynamics.
- Timmers, L.; Lim, S.K.; Hoefer, I.E.; Arslan, F.; Lai, R.C.; Oorschot, A.A.M. van; Goumans, M.J.; Strijder, C.; Sze, S.K.; Choo, A.; Piek, J.J.; Doevendans, P.A.; Pasterkamp, G. & Kleijn, D.P.V. de (2011), Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction, Stem Cell Research 6(3): 206-214.
- Sluijter, J.P.; Doevendans, P.A. & Goumans, M.J. (2011), Letter by Sluijter et al Regarding Article, "Human Cardiac Stem Cell Differentiation Is Regulated by a Mircrine Mechanism", Circulation 124(17): E456-E456.
- Meeteren, L.A. van; Goumans, M.J. & Dijke, P. ten (2011), TGF-beta Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy, Current Pharmaceutical Biotechnology 12(12): 2108-2120.
- Oorschot, A.A.M. van; Smits, A.M.; Pardali, E.; Doevendans, P.A. & Goumans, M.J. (2011), Low oxygen tension positively influences cardiomyocyte progenitor cell function, Journal of Cellular and Molecular Medicine 15(12): 2723-2734.
- Bax, N.A.M.; Pijnappels, D.A.; Oorschot, A.A.M. van; Winter, E.M.; Vries, A.A.F. de; Tuyn, J. van; Braun, J.; Maas, S.; Schalij, M.J.; Atsma, D.E.; Goumans, M.J. & Gittenberger-de Groot, A.C. (2011), Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells, Journal of Cellular and Molecular Medicine 15(12): 2675-2683.
- Orlova, V.V.; Liu, Z.; Goumans, M.J. & Dijke, P. ten (2011), Controlling angiogenesis by two unique TGF-beta type I receptor signaling pathways, Histology and Histopathology 26(9): 1219-1230.
- Egorova, A.D.; Heiden, K. van der; Pas, S. van de; Vennemann, P.; Poelma, C.; DeRuiter, M.C.; Goumans, M.J.T.H.; Gittenberger-de Groot, A.C.; Dijke, P. ten; Poelmann, R.E. & Hierck, B.P. (2011), Tgf beta/Alk5 Signaling Is Required for Shear Stress Induced Klf2 Expression in Embryonic Endothelial Cells, Developmental Dynamics 240(7): 1670-1680.
- Liu, J.; Mil, A. van; Vrijsen, K.; Zhao, J.J.; Gao, L.; Metz, C.H.G.; Goumans, M.J.; Doevendans, P.A. & Sluijter, J.P.G. (2011), MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1, Journal of Cellular and Molecular Medicine 15(7): 1474-1482.
- Mummery, C. & Goumans, M.J. (2011), Shedding New Light on the Mechanism Underlying Stem Cell Therapy for the Heart, Molecular Therapy 19(7): 1186-1188.
- Boekhorst, B.C.T.; Bovens, S.M.; Hellings, W.E.; Kraak, P.H. van der; Kolk, K.W.V. de; Vink, A.; Moll, F.L.; Oosterhout, M.F. van; Vries, J.P. de; Doevendans, P.A.; Goumans, M.J.; Kleijn, D.P. de; Echteld, C.J. van; Pasterkamp, G. & Sluijter, J.P. (2011), Molecular MRI of murine atherosclerotic plaque targeting NGAL: a protein associated with unstable human plaque characteristics, Cardiovascular Research 89(3): 680-688.
- Mummery, C. & Goumans, M.J. (2011), Shedding new light on the mechanism underlying stem cell therapy for the heart.
- Haan, M.C. den; Grauss, R.W.; Smits, A.M.; Winter, E.M.; Tuyn, J. van; Pijnappels, D.A.; Steendijk, P.; Gittenberger-De Groot, A.C.; Laarse, A. van der; Fibbe, W.E.; Vries, A.A.F. de; Schalij, M.J.; Doevendans, P.A.; Goumans, M.J. & Atsma, D.E. (2011), Cardiomyogenic differentiation-independent improvement of cardiac function by human cardiomyocyte progenitor cell injection in ischemic mouse hearts.
- Bot, P.T.; Grundmann, S.; Goumans, M.J.; Kleijn, D. de; Moll, F.; Boer, O. de; Wal, A.C. van der; Soest, A. van; Vries, J.P. de; Royen, N. van; Piek, J.J.; Pasterkamp, G. & Hoefer, I.E. (2011), Forkhead box protein P1 as a downstream target of transforming growth factor-beta induces collagen synthesis and correlates with a more stable plaque phenotype, Atherosclerosis 218(1): 33-43.
- Ramkisoensing, A.A.; Pijnappels, D.A.; Askar, S.F.A.; Passier, R.; Swildens, J.; Goumans, M.J.; Schutte, C.I.; Vries, A.A.F. de; Scherjon, S.; Mummery, C.L.; Schalij, M.J. & Atsma, D.E. (2011), Human Embryonic and Fetal Mesenchymal Stem Cells Differentiate toward Three Different Cardiac Lineages in Contrast to Their Adult Counterparts, PLoS ONE 6(9).
- Bax, N.A.M.; Oorschot, A.A.M. van; Maas, S.; Braun, J.; Tuyn, J. van; Vries, A.A.F. de; Gittenberger-de Groot, A.C. & Goumans, M.J. (2011), In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGF beta-signaling and WT1, Basic Research in Cardiology 106(5): 829-847.
- Lagendijk, A.K.; Goumans, M.J.; Burkhard, S.B. & Bakkers, J. (2011), MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production, Circulation Research 109(6): 649U149.
- Orlova, V.V.; Liu, Z.; Goumans, M.J. & Dijke, P. ten (2011), Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways., Histology and Histopathology 26(9): 1219-30.
- Egorova, A.D.; Khedoe, P.P.S.J.; Goumans, M.J.T.H.; Yoder, B.K.; Nauli, S.M.; Dijke, P. ten; Poelmann, R.E. & Hierck, B.P. (2011), Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition, Circulation Research 108(9): 1093-U142.
- Vries, M.R. de; Seghers, L.; Hoefer, I.E.; Pardali, E.; Hierck, B.P. van der; Goumans, M.J.; Dijke, P. ten & Quax, P.H. (2011), Endoglin and ALK1 Act Differently of Ischemia and Shear Stress Induced Neovascularization, Circulation 124(21).
- Bax, N.A.M.; Bleyl, S.B.; Gallini, R.; Wisse, L.J.; Hunter, J.; Oorschot, A.A.M. van; Mahtab, E.A.F.; Lie-Venema, H.; Goumans, M.J.; Betsholtz, C. & Gittenberger-de Groot, A.C. (2010), Cardiac Malformations in Pdgfr alpha Mutant Embryos Are Associated With Increased Expression of WT1 and Nkx2.5 in the Second Heart Field, Developmental Dynamics 239(8): 2307-2317.
- van Dinther M, Visser N, de Gorter DJ, Doorn J, Goumans MJ, de Boer J & ten Dijke P (2010), ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation., Journal of Bone and Mineral Research 25(6): 1208-15.
- Pardali E, Goumans MJ & ten Dijke P (2010), Signaling by members of the TGF-beta family in vascular morphogenesis and disease., Trends in Cell Biology 20(9): 556-67.
- Westerweel PE, van Velthoven CT, Nguyen TQ, den Ouden K, de Kleijn DP, Goumans MJ, Goldschmeding R & Verhaar MC (2010), Modulation of TGF-β/BMP-6 expression and increased levels of circulating smooth muscle progenitor cells in a type I diabetes mouse model., Cardiovascular Diabetology 9: 55.
- Post, S.; Goumans, M.J. & Doevendans, P.A. (2010), Peripheral Blood Derived Cell Trafficking for Cardiac Regeneration, Current Stem Cell Research and Therapy 5(4): 303-313.
- Westerweel, P.E.; Velthoven, C.T.J. van; Nguyen, T.Q.; Ouden, K. den; Kleijn, D.P.V. de; Goumans, M.J.; Goldschmeding, R. & Verhaar, M.C. (2010), Modulation of TGF-beta/BMP-6 expression and increased levels of circulating smooth muscle progenitor cells in a type I diabetes mouse model, Cardiovascular Diabetology 9.
- Bluyssen, H.A.R.; Rastmanesh, M.M.; Tilburgs, C.; Jie, K.; Wesseling, S.; Goumans, M.J.; Boer, P.; Joles, J.A. & Braam, B. (2010), IFN gamma-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells, American Journal of Physiology - Cell Physiology 299(2): C354C362.
- Post, S.; Smits, A.M.; Broek, A.J. van den; Sluijter, J.P.G.; Hoefer, I.E.; Janssen, B.J.; Snijder, R.J.; Mager, J.J.; Pasterkamp, G.; Mummery, C.L.; Doevendans, P.A. & Goumans, M.J. (2010), Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance, Cardiovascular Research 85(3): 494-502.
- Davidson ENB, Remst DFG, Vitters EL, van Beuningen HM, Blom AB, Goumans MJ, van den Berg WB & van der Kraan PM (2010), Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice (vol 182, pg 7937, 2009), Journal of Immunology 185(4): 2629-2629.
- Bijkerk, R.; Duijs, J.; Kobayashi, K.; Solingen, C. van; Roeten, M.K.; Veer, E.P. van der; Dijke, P. ten; Boer, H.C. de; Rabelink, T.J.; Goumans, M.J. & Zonneveld, A.J. van (2010), MicroRNA-155 Functions as a Suppressor of Endothelial to Mesenchymal Transition, Arteriosclerosis, Thrombosis, and Vascular Biology 30(11): E236E237.
- Smits AM, Ramkisoensing AA, Atsma DE & Goumans MJ (2010), Young at heart. An update on cardiac regeneration., Minerva Medica 101(4): 255-70.
- Oorschot, A.A.M. van; Smits, A.M. & Goumans, M.J. (2010), Stem cells: the building blocks to repair the injured heart, Panminerva Medica 52(2): 97-110.
- Van Mil A, Kamta BW, Goumans MJ, Doevendans PA & Sluijter JPG (2010), MicroRNA-1 regulates the angiogenic differentiation of human-derived cardiomyocyte progenitor cells, European Heart Journal 31: 21-21.
- Liu J, Vrijsen KR, Van Mil A, Oerlemans MIF, Goumans MJ, Doevendans PA & Sluijter JPG (2010), microRNA-155 blocks necrotic cell death in human cardiomyocyte progenitor cells by targeting RIP1, European Heart Journal 31: 82-82.
- Tian, F.; Zhou, A.X.; Smits, A.M.; Larsson, E.; Goumans, M.J.; Heldin, C.H.; Boren, J. & Akyurek, L.M. (2010), Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro, Biochemical and Biophysical Research Communications 392(3): 283-288.
- Vliet, P. van; Smits, A.M.; Boer, T.P. de; Korfage, T.H.; Metz, C.H.G.; Roccio, M.; Heyden, M.A.G. van der; Veen, T.A.B. van; Sluijter, J.P.G.; Doevendans, P.A. & Goumans, M.J. (2010), Foetal and adult cardiomyocyte progenitor cells have different developmental potential, Journal of Cellular and Molecular Medicine 14(4): 861-870.
- Sluijter, J.P.G.; Mil, A. van; Vliet, P. van; Metz, C.H.G.; Liu, J.; Doevendans, P.A. & Goumans, M.J. (2010), MicroRNA-1 and-499 Regulate Differentiation and Proliferation in Human-Derived Cardiomyocyte Progenitor Cells, Arteriosclerosis, Thrombosis, and Vascular Biology 30(4): 859U591.
- Boer, T.P. de; Veen, T.A.B. van; Jonsson, M.K.B.; Kok, B.G.J.M.; Metz, C.H.G.; Sluijter, J.P.G.; Doevendans, P.A.; Bakker, J.M.T. de; Goumans, M.J. & Heyden, M.A.G. van der (2010), Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype, Journal of Molecular and Cellular Cardiology 48(1): 254-260.
- Drewes, Y.M.; Gussekloo, J.; Meer, V. van der; Rigter, H.; Dekker, J.H.; Goumans, M.J.B.M.; Metsemakers, J.F.M.; Overbeek, R. van; Rooij, S.E. de; Schers, H.J.; Schuurmans, M.J.; Sturmans, F.; Vries, K. de; Westendorp, R.G.J.; Wind, A.W. & Assendelft, W.J.J. (2010), Assessment of evidence for screening community-dwelling older people, European Journal of Public Health 20: 35-35.
- Dinther, M. van; Visser, N.; Gorter, D.J.J. de; Doorn, J.; Goumans, M.J.; Boer, J. de & Dijke, P. ten (2010), ALK2 R206H Mutation Linked to Fibrodysplasia Ossificans Progressiva Confers Constitutive Activity to the BMP Type I Receptor and Sensitizes Mesenchymal Cells to BMP-Induced Osteoblast Differentiation and Bone Formation, Journal of Bone and Mineral Research 25(6): 1208-1215.
- Vliet, P. van; Boer, T.P. de; Heyden, M.A.G. van der; Tamer, M.K. el; Sluijter, J.P.G.; Doevendans, P.A. & Goumans, M.J. (2010), Hyperpolarization Induces Differentiation in Human Cardiomyocyte Progenitor Cells, Stem Cell Reviews and Reports 6(2): 178-185.
- Van Oorschot AA, Smits AM & Goumans MJ (2010), Stem cells: the building blocks to repair the injured heart., Panminerva Medica 52(2): 97-110.
- Bax, N.A.M.; Bleyl, S.B.; Gallini, R.; Wisse, L.J.; Hunter, J.; Oorschot, A.A.M. van; Mahtab, E.A.F.; Lie-Venema, H.; Goumans, M.J.; Betsholtz, C. & Gittenberger-de Groot, A.C. (2010), Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field., Developmental Dynamics 239(8): 2307-17.
- Haverslag RT, De Groot D, Grundmann S, Goumans MJ, De Kleijn DP, Pasterkamp G & Hoefer IE (2010), CD26 inhibition enhances perfusion recovery in ApoE-/- mice, European Heart Journal 31: 621-621.
- Smits, A.M.; Ramkisoensing, A.A.; Atsma, D.E. & Goumans, M.J. (2010), Young at heart. An update on cardiac regeneration, Minerva Medica 101(4): 255-269.
- Cunha, S.I.; Pardali, E.; Thorikay, M.; Anderberg, C.; Hawinkels, L.; Goumans, M.J.; Seehra, J.; Heldin, C.H.; Dijke, P. ten & Pietras, K. (2010), Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis, Journal of Experimental Medicine 207(1): 85-100.
- Pardali, E.; Goumans, M.J. & Dijke, P. ten (2010), Signaling by members of the TGF-beta family in vascular morphogenesis and disease, Trends in Cell Biology 20(9): 556-567.
- Oerlemans, M.I.F.J.; Goumans, M.J.; Middelaar, B. van; Clevers, H.; Doevendans, P.A. & Sluijter, J.P.G. (2010), Active Wnt signaling in response to cardiac injury, Basic Research in Cardiology 105(5): 631-641.
- Bot, P.T.; Pasterkamp, G.; Goumans, M.J.; Strijder, C.; Moll, F.L.; Vries, J.P. de; Pals, S.T.; Kleijn, D.P. de; Piek, J.J. & Hoefer, I.E. (2010), Hyaluronic acid metabolism is increased in unstable plaques, European Journal of Clinical Investigation 40(9): 818-827.
- den Haan MC, Grauss RW, Goumans MJ, Smits AM, Pijnappels DA, Steendijk P, Gittenberger-de Groot AC, van der Laarse A, de Vries AA, Schalij MJ, Doevendans PA & Atsma DE (2009), Attenuation of Ventricular Remodeling and Improvement of Left Ventricular Systolic Function by Injection of Human Fetal Cardiomyocyte Progenitor Cells After Acute Myocardial Infarction, Circulation 120(18): S1040S1040.
- Liu J, Sluijter JPG, Goumans MJ, Smits AM, van der Spoel T, Nathoe H & Doevendans PA (2009), Cell Therapy for Myocardial Regeneration, Current Molecular Medicine 9(3): 287-298.
- de Kleijn D, Timmers L, Hoefer I, Arslan F, van Oorschot A, Goumans MJ, Pasterkamp G, Lai RC & Lim SK (2009), Human Mesenchymal Stem Cells Secrete an Angiogenic Proteome That Stimulates Angiogenesis in vitro and in vivo and Improves Cardiac Function Following Myocardial Infarction, Circulation 120(18): S869S869.
- Smits AM, van den Hengel LG, van den Brink S, Metz CH, Doevendans PA & Goumans MJ (2009), A new in vitro model for stem cell differentiation and interaction, Stem Cell Research 2(2): 108-112.
- Oerlemans MI, Goumans MJ, Clevers H, Doevendans PA & Sluijter JP (2009), Active Wnt Signaling in Cardiac Response to Injury, Circulation 120(18): S847S847.
- Smits AM, van Laake LW, den Ouden K, Schreurs C, Szuhai K, van Echteld CJ, Mummery CL, Doevendans PA & Goumans MJ (2009), Human cardiomyocyte progenitor cell transplantation preserves long-term function of the infarcted mouse myocardium, Cardiovascular Research 83(3): 527-535.
- Bot PTG, Hoefer IE, Sluijter JPG, van Vliet P, Smits AM, Lebrin F, Moll F, de Vries JP, Doevendans P, Piek JJ, Pasterkamp G & Goumans MJ (2009), Increased Expression of the Transforming Growth Factor-beta Signaling Pathway, Endoglin, and Early Growth Response-1 in Stable Plaques, Stroke 40(2): 439-447.
- Smits AM, van Vliet P, Metz CH, Korfage T, Sluijter JPG, Doevendans PA & Goumans MJ (2009), Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology, Nature Protocols 4(2): 232-243.
- Jonsson MKB, van Veen TAB, Goumans MJ, Vos MA, Duker G & Sartipy P (2009), Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell-derived cardiomyocytes, Expert Opinion on Drug Discovery 4(4): 357-372.
- Davidson, E.N.B.; Remst, D.F.G.; Vitters, E.L.; Beuningen, H.M. van; Blom, A.B.; Goumans, M.J.; Berg, W.B. van den & Kraan, P.M. van der (2009), Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice, Journal of Immunology 182(12): 7937-7945.
- Itoh F, Itoh S, Carvalho RLC, Adachi T, Ema M, Goumans MJ, Larsson J, Karlsson S, Takahashi S & Mummery CL (2009), Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation, Laboratory Investigation 89(7): 800-810.
- Goumans MJ, Liu Z & ten Dijke P (2009), TGF-beta signaling in vascular biology and dysfunction., Cell Research 19(1): 116-27.
- Noort WA, Sluijter JPG, Goumans MJ, Chamuleau SAJ & Doevendans PA (2009), Stem Cells from In- or Outside of the Heart: Isolation, Characterization, and Potential for Myocardial Tissue Regeneration, Pediatric Cardiology 30(5): 699-709.
- Goumans MJ, Liu Z & ten Dijke P (2009), TGF-beta signaling in vascular biology and dysfunction, Cell Research 19(1): 116-127.
- Winter EM, van Oorschot AA, Hogers B, van der Graaf LM, Doevendans PA, Poelmann RE, Atsma DE, Gittenberger-de Groot AC & Goumans MJ (2009), A new direction for cardiac regeneration therapy: application of synergistically acting epicardium-derived cells and cardiomyocyte progenitor cells., Circulation: Heart Failure 2(6): 643-53.
- Winter, E.M.; Oorschot, A.A.M. van; Hogers, B.; Graaf, L.M. van der; Doevendans, P.A.; Poelmann, R.E.; Atsma, D.E.; Gittenberger-de Groot, A.C. & Goumans, M.J. (2009), A New Direction for Cardiac Regeneration Therapy Application of Synergistically Acting Epicardium-Derived Cells and Cardiomyocyte Progenitor Cells, Circulation: Heart Failure 2(6): 643-653.
- Liu Z, Kobayashi K, van Dinther M, van Heiningen SH, Valdimarsdottir G, van Laar T, Scharpfenecker M, Lowik CWGM, Goumans MJ & ten Dijke P (2009), VEGF and inhibitors of TGF beta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha 5-integrin expression, Journal of Cell Science 122(18): 3294-3302.
- Sluljter JP, van Vliet P, Fledderus JO, de Kleijn DP, Goumans MJ & Doevendans PA (2008), Temporal Gene Expression Profiling of Human-Derived Cardiomyocyte Progenitor Cells during Cardiomyocyte Differentiation, Circulation 118(18): S327-S327.
- Sluijtor JP, van Mil A, van Vliet P, Metz GH, Doevendans PA & Goumans MJ (2008), Microrna-499 Regulates (cardio)myocyte Differentiation in Human-Derived Cardiomyocyte Progenitor Cells, Circulation 118(18): S329-S329.
- Winter, E.M.; Oorschot van, A.A.; Goumans, M.J.; Hogers, B.; Maas, S.; Graaf van der, L.M.; Doevendans, P.A.; Atsma, D.E.; Poelmann, R.E. & Groot, A.C.G.D. (2008), Human Adult Epicardium-Derived Cells and Cardiomyocyte Progenitor Cells Act Synergistically in the Infarcted Adult Heart, Circulation 118(18): S500-S500.
- Hawinkels L, Goumans M & ten Dijke P (2008), TGF-beta Receptor Signal Transduction in Vascular Development, ICCB 2008: PROCEEDINGS OF THE 9TH INTERNATIONAL CONGRESS ON CELL BIOLOGY: 1-6.
- Van Tuyn J, Pijnappels DA, Haeck ML, Knaan-Shanzer S, Scherjon S, Goumans MJ, de Vries AA, van der Laarse A, Schalij MJ & Atsma DE (2008), Potential of Human Mesenchymal Stem Cells to Differentiate Into Cardiomyocytes Depends on Donor Age and Donor Tissue, Circulation 118(18): S421S421.
- Timmers L, Sluijter JPG, van Keulen JK, Hoefer IE, Nederhoff MGJ, Goumans MJ, Doevendans PA, van Echteld CJA, Joles JA, Quax PH, Piek JJ, Pasterkamp G & de Kleijn DPV (2008), Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction, Circulation Research 102(2).
- Goumans MJ, van Zonneveld AJ & ten Dijke P (2008), Transforming Growth Factor beta-Induced Endothelial-to-Mesenchymal Transition: A Switch to Cardiac Fibrosis?, Trends in Cardiovascular Medicine 18(8): 293-298.
- ten Dijke P, Goumans MJ & Pardali E (2008), Endoglin in angiogenesis and vascular diseases, Angiogenesis 11(1).
- Carvalho RL, Itoh F, Goumans MJ, Lebrin F, Kato M, Takahashi S, Ema M, Itoh S, van Rooijen M, Bertolino P, Ten Dijke P & Mummery CL (2007), Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice., Journal of Cell Science 120(Pt 24): 4269-77.
- Carvalho RLC, Itoh F, Goumans MJ, Lebrin F, Kato M, Takahashi S, Ema M, Itoh S, van Rooijen M, Bertolino P, ten Dijke P & Mummery CL (2007), Compensatory signalling induced in the yolk sac vasculature by deletion of TGF beta receptors in mice, Journal of Cell Science 120(24).
- Valdimarsdottir G, Goumans MJ, Itoh F, Itoh S, Heldin CH & ten Dijke P (2006), Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells., BMC Cell Biology 7: 16.
- Valdimarsdottir G, Goumans MJ, Itoh F, Itoh S, Heldin CH & ten Dijke P (2006), Smad7 and protein phosphatase 1 alpha are critical determinants in the duration of TGF-beta/ALKI signaling in endothelial cells, BMC Cell Biology 7.
- van Laake LW, van den Driesche S, Post S, Feijen A, Jansen MA, Driessens MH, Mager JJ, Snijder RJ, Westermann CJJ, Doevendans PA, van Echteld CJA, ten Dijke P, Arthur HM, Goumans MJ, Lebrin F & Mummery CL (2006), Endoglin has a crucial role in blood cell-mediated vascular repair, Circulation 114(21).
- Sluijter JPG, Verloop RE, Pulskens WPC, Velema E, Grimbergen JM, Quax PH, Goumans MJ, Pasterkamp G & de Kleijn DPV (2005), Involvement of furin-like proprotein convertases in the arterial response to injury, Cardiovascular Research 68(1).
- ten Dijke P, Carvalho R, Goumans MJ, Lebrin F, Arthur H & Mummery C (2005), TGF-beta in endothelial cell function and vascular development., Journal of Vascular Research 42: 10-11.
- Lebrin F, Goumans MJ, Jonker L, Carvalho RLC, Valdimarsdottir G, Thorikay M, Mummery C, Arthur HM & ten Dijke P (2004), Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction, EMBO Journal 23(20): 4018-4028.
- Goumans MJ, Valdimarsdottir G, Itoh S, Lebrin F, Larsson J, Mummery C, Karlsson S & ten Dijke P (2003), Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFP/ALK5 signaling, Molecular Cell 12(4): 817-828.
- ten Dijke P, Korchynskyi E, Valdimarsdottir G & Goumans MJ (2003), Controlling cell fate by bone morphogenetic protein receptors, Molecular and Cellular Endocrinology 211(1-2): 105-113.
- Dennler S, Goumans MJ & ten Dijke P (2002), Transforming growth factor beta signal transduction, Journal of Leukocyte Biology 71(5): 731-740.