Leon Aarts
Professor Anesthesiology
- Name
- Prof.dr. L.P.H.J. Aarts
- Telephone
- +31 71 526 6046
- l.p.h.j.aarts@lumc.nl
- ORCID iD
- 0000-0003-3068-7934
• Chief of the department of Anesthesiology and Pain medicine LUMC • Chairman of division 1 LUMC
Anesthesiology
Responsible for the development of Anesthesiology in clinical practice, education and research.
Academic career
1995 thesis Free University Amsterdam: Anesthesia and oxidative stress
2004 Inaugeration RUG Groningen: Primum non nocere
2010 Inaugeration University of Leiden: Anesthesiolgy and the crossing paths of care
Professor Anesthesiology
- Faculteit Geneeskunde
- LUMC - Medische Faculteit Leiden
- Divisie 1
- Anesthesiologie
- Zhang, C.; Adriaanse, M.A.; Potgieter, R.; Tummers, L.; Wit, J. de; Broersen, J.; Bruin, M. de & Aarts, H. (2022), Habit formation of preventive behaviours during the COVID-19 pandemic, BMC Public Health 22(1).
- Kamp, J.; Velzen, M. van; Aarts, L.; Niesters, M.; Dahan, A. & Olofsen, E. (2021), Stereoselective ketamine effect on cardiac output, British Journal of Anaesthesia 127(1): 23-31.
- Kamp, J.; Jonkman, K.; Velzen, M. van; Aarts, L.; Niesters, M.; Dahan, A. & Olofsen, E. (2020), Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis, British Journal of Anaesthesia 125(5): 750-761.
- G (2020), Deep neuromuscular block does not improve surgical conditions in patients receiving sevoflurane anesthesia for laparoscopic renal surgery, British Journal of Anaesthesia.
- Broens, S.J.L.; Boon, M.; Martini, C.H.; Niesters, M.; Velzen, M. van; Aarts, L.P.H.J. & Dahan, A. (2019), Influence of Reversal of a Partial Neuromuscular Block on the Ventilatory Response to Hypoxia, Anesthesiology.
- Meijer, F.S.; Martini, C.H.; Broens, S.; Boon, M.; Niesters, M.; Aarts, L.; Olofsen, E.; Velzen, M. van & Dahan, A. (2019), Nociception-guided versus Standard Care during Remifentanil-Propofol Anesthesia: A Randomized Controlled Trial., Anesthesiology 130(5).
- Broens, S.J.L.; Boon, M.; Martini, C.H.; Niesters, M.; Velzen, M. van; Aarts, L.P.H.J. & Dahan, A. (2019), Reversal of Partial Neuromuscular Block and the Ventilatory Response to Hypoxia A Randomized Controlled Trial in Healthy Volunteers, Anesthesiology 131(3): 467-476.
- Honing, G.H.M.; Martini, C.H.; Bom, A.; Velzen, M. van; Niesters, M.; Aarts, L.P.H.J.; Dahan, A. & Boon, M. (2019), Safety of sugammadex for reversal of neuromuscular block, Expert Opinion on Drug Safety 18(10): 883-891.
- Wink, J.; Veering, B.T.; Aarts, L.P.H.J. & Wouters, P.F. (2019), Effects of Thoracic Epidural Anesthesia on Neuronal Cardiac Regulation and Cardiac Function, Anesthesiology 130(3): 472-491.
- Meijer, F.S.; Martini, C.H.; Broens, S.; Boon, M.; Niesters, M.; Aarts, L.; Olofsen, E.; Velzen, M. van & Dahan, A. (2019), Nociception-guided versus Standard Care during Remifentanil-Propofol Anesthesia A Randomized Controlled Trial, Anesthesiology 130(5): 745-755.
- Algera, M.H.; Kamp, J.; Schrier, R. van der; Velzen, M. van; Niesters, M.; Aarts, L.; Dahan, A. & Olofsen, E. (2019), Opioid-induced respiratory depression in humans: a review of pharmacokinetic-pharmacodynamic modelling of reversal, British Journal of Anaesthesia 122(6): E168-E179.
- Boon, M.; Martini, C.H.; Aarts, L.P.H.J. & Dahan, A. (2019), The use of surgical rating scales for the evaluation of surgical working conditions during laparoscopic surgery: a scoping review, Surgical Endoscopy 33(1): 19-25.
- Vehmeijer W. B., Jonkman K., Hardarson S. H., Aarts L., Stefansson E., Dahan A. & Schalij-Delfos N. E. (2018), Retinal oximetry with a prototype oximeter during hyperoxia, Acta Ophthalmologica 96: 18-18.
- Dahan, A.; Schrier, R. van der; Smith, T.; Aarts, L.; Velzen, M. van & Niesters, M. (2018), Averting Opioid-induced Respiratory Depression without Affecting Analgesia, Anesthesiology 128(5): 1027-1037.
- Roozekrans, M.; Schrier, R. van der; Aarts, L.; Sarton, E.; Velzen, M. van; Niesters, M.; Dahan, A. & Olofsen, E. (2018), Benefit versus Severe Side Effects of Opioid Analgesia Novel Utility Functions of Probability of Analgesia and Respiratory Depression, Anesthesiology 128(5): 932-942.
- Jonkman, K.; Schrier, R. van der; Velzen, M. van; Aarts, L.; Olofsen, E.; Sarton, E.; Niesters, M. & Dahan, A. (2018), Differential role of nitric oxide in the psychedelic symptoms induced by racemic ketamine and esketamine in human volunteers, British Journal of Anaesthesia 120(5): 1009-1018.
- Jonkman, K.; Rijnsoever, E. van; Olofsen, E.; Aarts, L.; Sarton, E.; Velzen, M. van; Niesters, M. & Dahan, A. (2018), Esketamine counters opioid-induced respiratory depression, British Journal of Anaesthesia 120(5): 1117-1127.
- Berendsen, R.R.; Vessem, M.E. van; Bruins, M.; Teppema, L.J.S.M.; Aarts, L.P.H.J. & Kayser, B. (2018), Electronic Nose Technology Fails to Sniff Out Acute Mountain Sickness, High Altitude Medicine and Biology 19(3): 232-236.
- Vessem, M.E. van; Palmen, M.; Couperus, L.E.; Stijnen, T.; Berendsen, R.R.; Aarts, L.P.H.J.; Jonge, E. de; Klautz, R.J.M.; Schalij, M.J. & Beeres, S.L.M.A. (2018), Vasoplegia After Surgical Left Ventricular Restoration: 2-Year Follow-Up, Annals of Thoracic Surgery 106(5): 1371-1378.
- Boon, M.; Martini, C.; Yang, H.K.; Sen, S.S.; Bevers, R.; Warle, M.; Aarts, L.; Niesters, M. & Dahan, A. (2018), Impact of high- versus low-dose neuromuscular blocking agent administration on unplanned 30-day readmission rates in retroperitoneal laparoscopic surgery, PLoS ONE 13(5).
- Vehmeijer, W.; Hardarson, S.H.; Jonkman, K.; Aarts, L.; Dahan, A.; Stefansson, E. & Schalij-Delfos, N. (2018), Handheld Retinal Oximetry in Healthy Young Adults, Translational Vision Science & Technology 7(4).
- Vehmeijer, W.B.; Hardarson, S.H.; Jonkman, K.; Aarts, L.; Dahan, A.; Stefansson, E. & Schalij-Delfos, N.E. (2017), Handheld and mobile oximeter in a healthy adult population, Acta Ophthalmologica 95: 32-33.
- Culver, D.A.; Dahan, A.; Bajorunas, D.; Jeziorska, M.; Velzen, M. van; Aarts, L.P.H.J.; Tavee, J.; Tannemaat, M.R.; Dunne, A.N.; Kirk, R.I.; Petropoulos, I.N.; Cerami, A.; Malik, R.A. & Brines, M. (2017), Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain, Investigative Ophthalmology & Visual Science 58(6): BIO52-BIO60.
- Boon, M.; Martini, C.H.; Aarts, L.P.; Torensma, B. & Dahan, A. (2017), Deep Neuromuscular Block and Surgical Conditions During Bariatric Surgery, Anesthesia and Analgesia 124(6): 2094-2095.
- Schrier, R. van der; Roozekrans, M.; Olofsen, E.; Aarts, L.; Velzen, M. van; Jong, M. de; Dahan, A. & Niesters, M. (2017), Influence of Ethanol on Oxycodone-induced Respiratory Depression A Dose-escalating Study in Young and Elderly Individuals, Anesthesiology 126(3): 534-542.
- Jonkman, K.; Duma, A.; Olofsen, E.; Henthorn, T.; Velzen, M. van; Mooren, R.; Siebers, L.; Beukel, J. van den; Aarts, L.; Niesters, M. & Dahan, A. (2017), Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers, Anesthesiology 127(4): 675-683.
- Dahan, A.; Boom, M.; Sarton, E.; Hay, J.; Groeneveld, G.J.; Neukirchen, M.; Bothmer, J.; Aarts, L. & Olofsen, E. (2017), Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers, Anesthesiology 126(4): 697-707.
- Vriens, B.E.P.J.; Keymeulen, K.B.M.I.; Kroep, J.R.; Charehbili, A.; Peer, P.G.; Boer, M. de; Aarts, M.J.B.; Heuts, E.M.; Tjan-Heijnen, V.C.G. & Dutch Breast Canc Res Grp BOOG (2017), Axillary staging in breast cancer patients treated with neoadjuvant chemotherapy in two Dutch phase III studies, Oncotarget 8(28): 46557-46564.
- Franken, M.; Leeneman, B.; Jochems, A.; Schouwenburg, M.; Aarts, M.; Akkooi, A. van; Berkmortel, F. van den; Eertwegh, A. van den; Groot, J. de; Hoeven, J. van der; Hospers, G.; Kapiteijn, E.; Koornstra, R.; Kmit, W.; Louwman, M.; Piersma, D.; Rijn, R. van; Suijkerbuijk, K.; Tije, A. ten; Vreugdenhil, G.; Wouters, M.; Zeijl, M. van; Haanen, J. & Uyl-de Groot, C. (2017), HEALTHCARE COSTS OF IPILIMUMAB IN PATIENTS WITH ADVANCED CUTANEOUS MELANOMA IN DUTCH CLINICAL PRACTICE, Value in Health 20(9): A431-A431.
- Berendsen, R.R.; Lindeman, R.C.; Boom, M.; Aarts, L.P.H.J.; Dorp, E.L.A. van & Teppema, L.J. (2016), Erythropoietin does not have effects on the ventilatory and pulmonary vascular response to acute hypoxia in men and women, Experimental Physiology 101(9): 1230-1240.
- Wink, J.; Wilde, R.B.P. de; Wouters, P.F.; Dorp, E.L.A. van; Veering, B.T.; Versteegh, M.I.M.; Aarts, L.P.H.J. & Steendijk, P. (2016), Thoracic Epidural Anesthesia Reduces Right Ventricular Systolic Function With Maintained Ventricular-Pulmonary Coupling, Circulation 134(16): 1163-1175.
- Wit, F. de; Vliet, A.L. van; Wilde, R.B. de; Jansen, J.R.; Vuyk, J.; Aarts, L.P.; Jonge, E. de; Veelo, D.P. & Geerts, B.F. (2016), The effect of propofol on haemodynamics: cardiac output, venous return, mean systemic filling pressure, and vascular resistances, British Journal of Anaesthesia 116(6).
- Martini, C.H.; Proto, P.; Olofsen, E.; Velzen, M. van; Aarts, L.; Dahan, A. & Niesters, M. (2015), A randomized controlled trial and novel mathematical analysis of the analgesic effect of oxycodone versus paracetamol orodispersible tablets, European Journal of Pain 19(3): 295-304.
- Martini, C.; Velzen, M. van; Drewes, A.; Aarts, L.; Dahan, A. & Niesters, M. (2015), A Randomized Controlled Trial on the Effect of Tapentadol and Morphine on Conditioned Pain Modulation in Healthy Volunteers, PLoS ONE 10(6).
- (2014), Effect of deafferentation from spinal anesthesia on pain sensitivity and resting-state functional brain connectivity in healthy male volunteers., Brain Connectivity.
- Cherpanath, T.G.V.; Aarts, L.P.H.J.; Groeneveld, J.A.B. & Geerts, B.F. (2014), Defining Fluid Responsiveness: A Guide to Patient-Tailored Volume Titration, Journal of Cardiothoracic and Vascular Anesthesia 28(3): 745-754.
- Swartjes, M.; Velzen, M. van; Niesters, M.; Aarts, L.; Brines, M.; Dunne, A.; Cerami, A. & Dahan, A. (2014), ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response.
- Kortekaas, K.A.; Baan, A. van der; Aarts, L.P.H.J.; Palmen, M.; Cobbaert, C.M.; Verhagen, J.C.M.; Engbers, F.H.M.; Klautz, R.J.M. & Lindeman, J.H.N. (2014), Cardiospecific sevoflurane treatment quenches inflammation but does not attenuate myocardial cell damage markers: a proof-of-concept study in patients undergoing mitral valve repair, British Journal of Anaesthesia 112(6): 1005-1014.
- Kooiman, J.; Sijpkens, Y.W.J.; Buren, M. van; Groeneveld, J.H.M.; Ramai, S.R.S.; Molen, A.J. van der; Aarts, N.J.M.; Rooden, C.J. van; Cannegieter, S.C.; Putter, H.; Rabelink, T.J. & Huisman, M.V. (2014), Randomised trial of no hydration vs. sodium bicarbonate hydration in patients with chronic kidney disease undergoing acute computed tomography-pulmonary angiography, Journal of Thrombosis and Haemostasis 12(10): 1658-1666.
- Kooiman, J.; Sijpkens, Y.W.J.; Vries, J.P.P.M. de; Brulez, H.F.H.; Hamming, J.F.; Molen, A.J. van der; Aarts, N.J.M.; Cannegieter, S.C.; Putter, H.; Swarts, R.; Hout, W.B. van den; Rabelink, T.J. & Huisman, M.V. (2014), A randomized comparison of 1-h sodium bicarbonate hydration versus standard peri-procedural saline hydration in patients with chronic kidney disease undergoing intravenous contrast-enhanced computerized tomography, Nephrology Dialysis Transplantation 29(5): 1029-1036.
- Wink, J.; Veering, B.T.; Aarts, L.P.H.J. & Wouters, P.F. (2014), Effect of increasing age on the haemodynamic response to thoracic epidural anaesthesia An observational study, European Journal of Anaesthesiology 31(11): 597-605.
- Overdyk & F (2014), Opioid-induced respiratory depression in the acute care setting: a compendium of case reports, Pain Management 4(4).
- Niesters, M.; Overdyk, F.; Smith, T.; Aarts, L. & Dahan, A. (2013), Opioid-induced respiratory depression in paediatrics: a review of case reports, British Journal of Anaesthesia 110(2): 175-182.
- Dahan, A.; Overdyk, F.; Smith, T.; Aarts, L. & Niesters, M. (2013), Pharmacovigilance: A Review of Opioid-Induced Respiratory Depression in Chronic Pain Patients, Pain Physician 16(2): E85-E94.
- Dahan, A.; Roozekrans, M.; Schrier, R. van der; Smith, T. & Aarts, L. (2013), Primum Non Nocere or How to Resolve Drug-induced Respiratory Depression, Anesthesiology 118(6): 1261-1263.
- Swartjes, M.; Niesters, M.; Heij, L.; Dunne, A.; Aarts, L.; Hand, C.C.; Kim, H.S.; Brines, M.; Cerami, A. & Dahan, A. (2013), Ketamine Does Not Produce Relief of Neuropathic Pain in Mice Lacking the beta-Common Receptor (CD131), PLoS ONE 8(8).
- Niesters, M.; Mahajan, R.P.; Aarts, L. & Dahan, A. (2013), High-inspired oxygen concentration further impairs opioid-induced respiratory depression, British Journal of Anaesthesia 110(5): 837-841.
- Boom, M.; Olofsen, E.; Neukirchen, M.; Fussen, R.; Hay, J.; Groeneveld, G.J.; Aarts, L.; Sarton, E. & Dahan, A. (2013), Fentanyl Utility Function: A Risk-Benefit Composite of Pain Relief and Breathing Responses, Anesthesiology 119(3): 663-674.
- Wink, J.; Wolterbeek, R.; Aarts, L.P.H.J.; Koster, S.C.E.; Versteegh, M.I.M. & Veering, B.T.H. (2013), Upper thoracic epidural anaesthesia: effects of age on neural blockade and cardiovascular parameters, Acta Anaesthesiologica Scandinavica 57(6): 767-775.
- Niesters, M.; Aarts, L.; Sarton, E. & Dahan, A. (2013), Influence of ketamine and morphine on descending pain modulation in chronic pain patients: a randomized placebo-controlled cross-over proof-of-concept study, British Journal of Anaesthesia 110(6): 1010-1016.
- Maas, J.J.; Wilde, R.B. de; Aarts, L.P.; Pinsky, M.R. & Jansen, J.R. (2012), Determination of Vascular Waterfall Phenomenon by Bedside Measurement of Mean Systemic Filling Pressure and Critical Closing Pressure in the Intensive Care Unit, Anesthesia and Analgesia 114(4): 803-810.
- Luiking, M.L.; Linge, R. van; Bras, L.; Grypdonck, M. & Aarts, L. (2012), Psychometric properties of the Dutch version of the American nursing activity scale in an intensive care unit, Journal of Advanced Nursing 68(12): 2750-2755.
- Maas, J.J.; Pinsky, M.R.; Aarts, L.P. & Jansen, J.R. (2012), Bedside Assessment of Total Systemic Vascular Compliance, Stressed Volume, and Cardiac Function Curves in Intensive Care Unit Patients, Anesthesia and Analgesia 115(4): 880-887.
- Calis P, Berendsen R, Logeman A, Sarton E & Aarts L (2010), Anesthetic considerations in a patient with amiodarone-induced thyrotoxicosis., Case Reports in Medicine 2010: 984981.
- Dahan, A.; Aarts, L. & Smith, T. (2010), Postoperative Opioids Remain a Serious Patient Safety Threat Reply, Anesthesiology 113(1): 260-261.
- Olofsen, E.; Boom, M.; Nieuwenhuijs, D.; Sarton, E.; Teppema, L.; Aarts, L. & Dahan, A. (2010), Modeling the Non-Steady State Respiratory Effects of Remifentanil in Awake and Propofol-sedated Healthy Volunteers, Anesthesiology 112(6): 1382-1395.
- Olofsen, E.; Mooren, R.; Dorp, E. van; Aarts, L.; Smith, T.; Hartigh, J. den; Dahan, A. & Sarton, E. (2010), Arterial and Venous Pharmacokinetics of Morphine-6-Glucuronide and Impact of Sample Site on Pharmacodynamic Parameter Estimates, Anesthesia and Analgesia 111(3): 626-632.
- Dahan, A.; Aarts, L. & Smith, T.W. (2010), Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression, Anesthesiology 112(1): 226-238.
- Niesters, M.; Dahan, A.; Kest, B.; Zacny, J.; Stijnen, T.; Aarts, L. & Sarton, E. (2010), Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies, PAIN 151(1): 61-68.
- Noppers, I.; Niesters, M.; Aarts, L.; Smith, T.; Sarton, E. & Dahan, A. (2010), Ketamine for the treatment of chronic non-cancer pain, Expert Opinion on Pharmacotherapy 11(14): 2417-2429.
- Olofsen, E.; Dorp, E. van; Teppema, L.; Aarts, L.; Smith, T.W.; Dahan, A. & Sarton, E. (2010), Naloxone Reversal of Morphine- and Morphine-6-Glucuronide-induced Respiratory Depression in Healthy Volunteers A Mechanism-based Pharmacokinetic-Pharmacodynamic Modeling Study, Anesthesiology 112(6): 1417-1427.
- Peeters MMM, Bras LJ, DeJongh J, Wesselink RMJ, Aarts LPHJ, Danhof M & Knibbe CAJ (2008), Disease severity is a major determinant for the pharmacodynamics of propofol in critically ill patients, Clinical Pharmacology and Therapeutics 83(3).
- Wulfert FM, van Meurs M, de Haes A, Knol AJ, Houwertjes M, Zijlstra JG, Aarts LPHJ & Molema G (2008), Endothelial microvascular activation in hemorrhagic shock: The role of the neutrophil, Shock 29.
- Dieperink W, Nijsten MWN, van de Stadt M, van der Horst ICC, Aarts LPHJ, Zijlstra F & Jaarsma T (2008), Implementation of Boussignac continuous positive airway pressure in the coronary care unit: Experiences and attitudes, Heart & Lung: The Journal of Acute and Critical Care 37(6).
- van Boven WJP, Gerritsen WB, Driessen AH, Morshuis WJ, Waanders FG, Haas FJ, van Dongen EP & Aarts LP (2008), Myocardial oxidative stress, and cell injury comparing three different techniques for coronary artery bypass grafting, European Journal of Cardio-Thoracic Surgery 34(5).
- Voorzitter Concilium NVA