Carbohydrates, the most diverse and complex class of biomolecules in Nature, are the focus of the research of Jeroen Codée, who aims to unravel their mode of action through the design and synthesis of well-defined glycocojugates as well as inhibitors and probes.

More information about Jeroen Codee

Curriculum Vitae

Personal information

Nationality:   Dutch
Date of birth:   30 July 1975

Education

2004   PhD, Leiden Institute of Chemistry, Leiden University, The Netherlands, 29 September 2004. Thesis title: “Chemical Synthesis of Oligosaccharides - A focus on thioglycosides and glycosaminoglycans”
Advisors: Prof. Dr. J.H. van Boom and Prof. Dr. C.A.A. van Boeckel
1999   MSc in Chemistry, Faculty of Chemistry, Leiden University, The Netherlands

Current and previous research positions

2020 - now   Full Professor of Organic Chemistry, Leiden Institute of Chemistry, Leiden University, The Netherlands
2009 – 2020  Assistant Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2007 – 2009   Post-doctoral Researcher (Veni), Leiden University, Leiden, The Netherlands, (Prof. G.A. van der Marel)
2004 – 2006   Post-doctoral Researcher (TALENT stipend), Eidgenossische Technische Hochschule (ETH) Zürich, Switzerland (Prof. P.H. Seeberger)

Grants, awards, recognitions since 2010

2023   Emil Fischer Award
2023   NWO Snellius Supercomputer time (main applicant, 11.206.400 SBU)
2021   NWO Cartesius Supercomputer time (main applicant, 6.600.000 SBU)
2020   ICI “Amsterdam-Leiden-Nijmegen vaccine consortium: synthetic peptide conjugates for cancer therapy” (co-applicant, k€ 750)
2020   NWO Cartesius Supercomputer time (main applicant, 3.695.650 SBU)
2019   Marie Curie ITN “PAVax” (coordinator, k€ 1.054)
2019   NWO VICI “Dissecting glycosylation reaction mechanisms” (main applicant, k€ 1.500)
2018   NWO TOP “ENDOGLYCOPROBE” (co-applicant with H. Overkleeft and H. Aerts, k€ 780)
2018   NWO LISA Supercomputer time (main applicant, 2.150.550 SBU)
2017   Carbohydrate Research Award for Creativity in Carbohydrate Chemistry
2016   ERC Consolidator grant (k€ 2,000)
2015   NWO-CW ECHO grant (k€ 260)     
2015   EU Marie Curie ITN Grant “GLYCOVAX” (k€ 468)
2014   EU Marie Curie ITN Grant “IMMUNOSHAPE” (k€ 218)
2013   NWO KIEM (k€ 19)
2012   NWO-CW Middelgroot grant with Prof. van der Marel (k€ 129)
2011   NWO-CW ECHO grant with Prof. van der Marel (k€ 260)

Contribution to teaching and supervision

• Course ‘Biomolecular Chemistry’ for BSc Molecular Science and Technology (Leiden/Delft)
• Courses ‘Reactivity on Organic Chemistry’, and ‘Molecules of Life’ for MSc Chemistry (Leiden)

Current supervision of 13 PhD students. PhD supervisor of 39 PhD theses (2 cum laude and awarded with the Backer Prize for best Organic Chemistry Thesis in the Netherlands) and 26 PDs since 2011. 

Other responsibilities since 2016

• Organizer Glycoscience NL, 2023, Utrecht, NL
• Editor European Journal of Organic Chemistry, 2022 “Carbohydrate Chemistry”
• Editor of Drug Discovery Today: Technologies, Vol 35-36, 2020 “Translating basic research into novel vaccines”
• Organizer Eurocarb XX, 2019, Leiden, NL
• Editor of Carbohydrate Chemistry: Proven Synthetic Methods – Volume 2
• Chairman of the exam committee of the BSc curriculum MST (Leiden/Delft)
• Member of review panel for the Netherlands Organisation for Scientific Research (NWO, Vici panels 2022, 2023)
• Member of the education committee of the BSc programme MST (Leiden/Delft, 2015-2016)
• Member of the Leiden Institute of Chemistry Council (2013-)
• External member to PhD committees in Australia, Canada, Denmark, Ireland, Belgium, Letland, Sweden, Netherlands
• Reviewer for all major (organic)  chemistry journals: Nature Chemistry, Nature Communications, Angewandte Chemie, Journal of the American Chemical Society, Chemical Science, Chemistry – A European Journal

Publication record including five recent representative publications

224 papers and book chapters with 6396 citations, H-index 41 (Web of Science)

Full publication record: Leiden University

• Z. Wang, A. Poveda, Q. Zhang, L. Unione, H. S. Overkleeft, G. A. van der Marel, J. Jiménez-Barbero, J. D. C. Codée, Total synthesis and structural studies of zwitterionic Bacteroides fragilis polysaccharide A1 fragments J. Am. Chem. Soc. 2023, 145, 14052-14063. DOI: 10.1021/jacs.3c03976
• S. Ishizuka, J. H. M. van Dijk, T. Kawakita, Y. Miyamoto, Y. Maeda, M. Goto, G. Le Calvez, L. M. Groot, M. D. Witte, A. J. Minnaard, G. A. van der Marel, M. Ato, M. Nagae, J. D. C. Codée, S. Yamasaki, PGL-III, a rare intermediate of Mycobacterium leprae phenolic glycolipid biosynthesis, is a potent Mincle ligand ACS Centr. Sci. 2023, 9, 1388-1399. DOI: 10.1021/acscentsci.3c00040
• J. M.A. van Hengst, R. J.C. Hellemons, W. A. Remmerswaal, K. N. A. van de Vrande, T. Hansen, S. van der Vorm, H. S. Overkleeft, G. A. van der Marel, J. D. C. Codée, Mapping the effect of configuration and protecting group pattern on glycosyl acceptor reactivity Chem. Sci. 2023, 14, 1532-1542. DOI: 10.1039/D2SC06139B
• C. Di Carluccio, P. Soriano Maldonado, F. Berni, C. J. C. de Haas, A. R. Temming, A. Hendriks,  S. Ali,  A. Molinaro,  A. Silipo,  N. M. van Sorge, M. J. van Raaij, J. D. C. Codée, R. Marchetti, Antibody recognition of different Staphylococcus aureus wall teichoic acid glycoforms. ACS Centr. Sci. 2022, 8, 1383-1392. DOI: 10.1021/acscentsci.2c00125
• N. R. M. Reintjens, E. Tondini, A. R. de Jong, N. J. Meeuwenoord, F. Chiodo, E. Peterse, H. S. Overkleeft, D. V. Filippov, G. A. van der Marel, F. A. Ossendorp, J. D. C. Codée, Self-adjuvanting cancer vaccines from conjugation-ready lipid A analogues and synthetic long peptides J. Med. Chem. 2020, 63, 11691-11706. DOI: 10.1021/acs.jmedchem.0c00851

Presentations including five presentations at international conferences since 2016

>60 invited presentations at universities and institutes, and invited, and keynote lectures at international conferences since 2012

• Eurocarb XXI, 9-13 July 2023, Paris, France, plenary lecture
• RSC Carbohydrate Group Autumn Meeting, 22-23 November 2022, Belfast, UK, plenary lecture
• Pacifichem, 18 December 2022, Hawaii, USA, invited lecture
• French GlycoSciences Group Conference, 21-25 May 2018, plenary lecture
• European Carbohydrate Symposium, 2-6 July 2017, Barcelona, Spain, plenary lecture

Publications

Activities