James Hardwick
Professor Gastroenterology and Hepatology, in particular the early detection and treatment of colorectal tumours
- Name
- Prof.dr. J.C.H. Hardwick
- Telephone
- +31 71 526 5364
- j.c.h.hardwick@lumc.nl
- ORCID iD
- 0000-0002-9575-5099
James Hardwick is Professor of Gastroenterology and Hepatology, in particular the Early Detection and Treatment of Colorectal Tumours.
More information about James Hardwick
James Hardwick is Professor of Gastroenterology and Hepatology, in particular the Early Detection and Treatment of Colorectal Tumours.
Gastroenterology and Hepatology
Bowel cancer affects one in twenty in the Dutch population and is the most deadly form of cancer after lung cancer. Prof Hardwick is researching new methods of detecting bowel cancer and remove them in an “organ sparing” manner. His research also focusses on unravelling the molecular development of bowel cancer.
Academic career
James Hardwick was educated in Gastroenterology and General Internal Medicine in England. He moved to Amsterdam in 1999 and on the 25th September 2002 received a PhD from the University of Amsterdam with a thesis entitled “Molecular Mechanisms in Colon Cancer”. He left Amsterdam for Leiden in 2007 to continue his research. His areas of research interest are the role of the BMP signalling pathway in the development and progression of bowel cancer, chemoprevention of bowel cancer, new endoscopic techniques to detect bowel cancer precursors and minimally invasive techniques to remove precursors of bowel cancer. He held his inaugural lecture with the title “Colon cancer through the looking glass” on September 18 2015.
Professor Gastroenterology and Hepatology, in particular the early detection and treatment of colorectal tumours
- Faculteit Geneeskunde
- Divisie 2
- Maag-, Darm- en Leverziekten
- Dekkers, N.; Dang, H.; Graaf, M. de; Nobbenhuis, K.; Verhoeven, D.A.; Kraan, J. van der; Cappel, W.H.D.T.N.; Alkhalaf, A.; Westreenen, H.L. van; Basiliya, K.; Peeters, K.C.M.J.; Westerterp, M.; Doornebosch, P.G.; Hardwick, J.C.H.; Langers, A.M.J. & Boonstra, J.J. (2024), T1 colorectal cancer patients' perspective on information provision and therapeutic decision-making after local resection, United European Gastroenterology Journal.
- Verhoeven, D.A.; Moons, L.M.G.; Koch, A.D.; Hardwick, J.C.H.; Boonstra, J.J. & Dang, H. (2024), It's all about time: evaluation of the updated Zhongshan colorectal endoscopic submucosal dissection model in Western endoscopic submucosal dissection practice, Gastrointestinal Endoscopy 99(6): 1076-1078.
- Dang, H.; Harryvan, T.J.; Liao, C.Y.; Danen, E.H.J.; Spalburg, V.N.L.N.; Kielbasa, S.M.; Mei, H.L.; Goeman, J.J.; Jonge-Muller, E.S. de; Janson, S.G.T.; Reijden, J.J. van der; Crobach, S.; Hardwick, J.C.H.; Boonstra, J.J.; Miranda, N.F.C.C. de & Hawinkels, L.J.A.C. (2023), Cancer-associated fibroblasts are key determinants of cancer cell Invasion in the earliest stage of colorectal cancer, Cellular and Molecular Gastroenterology and Hepatology 16(1): 107-131.
- Dang, H.; Dekkers, N.; Steyerberg, E.W.; Baldaque-Silva, F.; Omae, M.; Haasnoot, K.J.C.; Tilburg, L. van; Nobbenhuis, K.; Kraan, J. van der; Langers, A.M.J.; Hooft, J.E. van; Graaf, W. de; Koch, A.D.; Didden, P.; Moons, L.M.G.; Hardwick, J.C.H. & Boonstra, J.J. (2023), Predicting procedure duration of colorectal endoscopic submucosal dissection at Western endoscopy centers (vol 11, pg E724, 2023), Endoscopy International Open 11(8): C5-C5.
- Dang, R.H.; Dekkers, N.; Steyerberg, E.W.; Baldaque-Silva, F.; Omae, M.; Haasnoot, K.J.C.; Tilburg, L. van; Nobbenhuis, K.; Kraan, J. van der; Langers, A.M.J.; Hooft, J.E. van; Graaf, W. de; Koch, A.D.; Didden, P.; Moons, L.M.G.; Hardwick, J.C.H. & Boonstra, J.J. (2023), Predicting procedure duration of colorectal endoscopic submucosal dissection at Western endoscopy centers, Endoscopy International Open 11(08): E724-E732.
- Dekkers, N.; Dang, H.; Vork, K.; Langers, A.M.J.; Kraan, J. van der; Westerterp, M.; Peeters, K.C.M.J.; Holman, F.A.; Koch, A.D.; Graaf, W. de; Didden, P.; Moons, L.M.G.; Doornebosch, P.G.; Hardwick, J.C.H. & Boonstra, J.J. (2023), Outcome of completion surgery after endoscopic submucosal dissection in early-stage colorectal cancer patients, Cancers 15(18).
- Dekkers, N.; Zonoobi, E.; Dang, H.; Warmerdam, M.I.; Crobach, S.; Langers, A.M.J.; Kraan, J. van der; Hilling, D.E.; Peeters, K.C.M.J.; Holman, F.A.; Vahrmeijer, A.L.; Sier, C.F.M.; Hardwick, J.C.H. & Boonstra, J.J. (2023), Colorectal polyps, United European Gastroenterology Journal 11(3).
- Dang, H.; Dekkers, N.; Steyerberg, E.W.; Nobbenhuis, K.; Haasnoot, K.J.; Tilburg, L. van; Kraan, J. van der; Langers, A.M.; Graaf, W. de; Koch, A.D.; Didden, P.; Moons, L.M.G.; Hooft, J.E. van; Hardwick, J. & Boonstra, J. (2022), TIME PLANNING OF COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION AT TERTIARY WESTERN CENTERS: DEVELOPMENT OF A PREDICTION MODEL FOR PROCEDURE DURATION (CESD-TIME FORMULA), Gastrointestinal Endoscopy 95(6): AB62-AB63.
- Harryvan, T.J.; Visser, M.; Bruin, L. de; Plug, L.; Griffioen, L.; Mulder, A.; Veelen, P.A. van; Noort, G.J.V. van; Jongsma, M.L.; Meeuwsen, M.H.; Wiertz, E.J.; Santegoets, S.J.; Hardwick, J.C.; Hall, T. van; Neefjes, J.; Burg, S.H. van der; Hawinkels, L.J.A.C. & Verdegaal, E.M.E. (2022), Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S, Journal for ImmunoTherapy of Cancer 10(3).
- Dekkers, N.; Dang, H.; Kraan, J. van der; Cessie, S. le; Oldenburg, P.P.; Schoones, J.W.; Langers, A.M.; Leerdam, M. van; Hooft, J.E. van; Backes, Y.; Levic, K.; Meining, A.; Saracco, G.; Holman, F.A.; Peeters, K.; Moons, L.M.G.; Doornebosch, P.G.; Hardwick, J. & Boonstra, J. (2022), RECURRENCE AFTER LOCAL SURGICAL RESECTION OF T1 RECTAL CANCER: A META-ANALYSIS AND COMPARISON WITH ENDOSCOPIC RESECTION, Gastrointestinal Endoscopy 95(6): AB140-AB140.
- Dekkers, N.; Dang, H.; Kraan, J. van der; Cessie, S. le; Oldenburg, P.P.; Schoones, J.W.; Langers, A.M.J.; Leerdam, M.E. van; Hooft, J.E. van; Backes, Y.; Levic, K.; Meining, A.; Saracco, G.M.; Holman, F.A.; Peeters, K.C.M.J.; Moons, L.M.G.; Doornebosch, P.G.; Hardwick, J.C.H. & Boonstra, J.J. (2022), Risk of recurrence after local resection of T1 rectal cancer, Surgical Endoscopy 36(12): 9156-9168.
- Dekkers, N.; Dang, H.; Kraan, J. van der; Cessie, S. le; Oldenburg, P.P.; Schoones, J.W.; Langers, A.M.J.; Leerdam, M.E. van; Hooft, J.E. van; Backes, Y.; Levic, K.; Meining, A.; Saracco, G.M.; Holman, F.A.; Peeters, K.C.M.J.; Moons, L.M.G.; Doornebosch, P.G.; Hardwick, J.C.H. & Boonstra, J.J. (2022), Risk of recurrence after local resection of T1 rectal cancer, Surgical Endoscopy 36.
- Roelands, J.; Ploeg, M. van der; Ijsselsteijn, M.E.; Dang, H.; Boonstra, J.J.; Hardwick, J.C.H.; Hawinkels, L.J.A.C.; Morreau, H. & Miranda, N.F.C.C. de (2022), Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis, Gut 72(7).
- Dang, H.; Harrijvan, T.J.; Liao, A.; Danen, E.H.; Miranda, N.F. de; Hardwick, J.; Boonstra, J. & Hawinkels, L. (2022), CANCER-ASSOCIATED FIBROBLASTS IN T1 COLORECTAL CANCER PROMOTE MATRIX REMODELING AND TUMOR ORGANOID EXPANSION, Gastroenterology 162(7): S323-S323.
- Ouahoud, S.; Westendorp, B.F.; Voorneveld, P.W.; Abudukelimu, S.; Koelink, P.J.; Garcia, E.P.; Buuren, J.F.I.; Harryvan, T.J.; Lenos, K.J.; Wezel, T. van; Offerhaus, J.A.; Farina-Sarasqueta, A.; Crobach, S.; Slingerland, M.; Hardwick, J.C.H. & Hawinkels, L.J.A.C. (2022), Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development, Journal of Gastroenterology 58.
- Dang, H.; Dekkers, N.; Cessie, S. le; Hooft, J.E. van; Leerdam, M.E. van; Oldenburg, P.P.; Flothuis, L.; Schoones, J.W.; Langers, A.M.J.; Hardwick, J.C.H.; Kraan, J. van der & Boonstra, J.J. (2022), Risk and time pattern of recurrences after local endoscopic resection of T1 colorectal cancer, Clinical Gastroenterology and Hepatology 20(2).
- Ouahoud, S.; Jacobs, R.J.; Peppelenbosch, M.P.; Fuhler, G.M.; Heijmans, J.; Diks, S.; Wildenberg, M.E.; Hawinkels, L.J.A.C.; Kodach, L.L.; Voorneveld, P.W. & Hardwick, J.C.H. (2021), Kinome-wide analysis of the effect of statins in colorectal cancer (Mar, 10.1038/s41416-021-01318-9, 2021), British Journal of Cancer 125(1): 144-144.
- Ouahoud, S.; Jacobs, R.J.; Kodach, L.L.; Voorneveld, P.W.; Hawinkels, L.J.A.C.; Weil, N.L.; Vliet, B. van; Herings, R.M.; Burg, L.R.A. van der; Wezel, T. van; Morreau, H.; Slingerland, M.; Bastiaannet, E.; Putter, H. & Hardwick, J.C.H. (2021), Statin use is associated with a reduced incidence of colorectal cancer expressing SMAD4, British Journal of Cancer.
- Chua, J.S.; Dang, H.; Zwager, L.; Dekkers, N.; Hardwick, J.C.H.; Langers, A.M.J.; Kraan, J. van der; Perk, L.E.; Bastiaansen, B.A.J.; Boonstra, J.J. & Dutch eFTR Working Grp (2021), Hybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer, Endoscopy International Open 09(11): E1686-E1691.
- Hardwick, J.C.H. (2021), Tattoo you?, Endoscopy.
- Ouahoud, S.; Jacobs, R.J.; Peppelenbosch, M.P.; Fuhler, G.M.; Heijmans, J.; Diks, S.; Wildenberg, M.E.; Hawinkels, L.J.A.C.; Kodach, L.L.; Voorneveld, P.W. & Hardwick, J.C.H. (2021), Kinome-wide analysis of the effect of statins in colorectal cancer, British Journal of Cancer 124.
- Dang, H.; Pelt, G.W. van; Haasnoot, K.J.C.; Backes, Y.; Elias, S.G.; Seerden, T.C.J.; Schwartz, M.P.; Spanier, B.W.M.; Cappel, W.H.D.T.N.; Bergeijk, J.D. van; Kessels, K.; Geesing, J.M.J.; Groen, J.N.; Borg, F. ter; Wolfhagen, F.H.J.; Seldenrijk, C.A.; Raicu, M.G.; Milne, A.N.; Lent, A.U.G. van; Brosens, L.A.A.; Offerhaus, G.J.A.; Siersema, P.D.; Tollenaar, R.A.E.M.; Hardwick, J.C.H.; Hawinkels, L.J.A.C.; Moons, L.M.G.; Lacle, M.M.; Mesker, W.E. & Boonstra, J.J. (2021), Tumour-stroma ratio has poor prognostic value in nonpedunculated T1 colorectal cancer, United European Gastroenterology Journal 9(4).
- Ouahoud, S.; Voorneveld, P.W.; Burg, L.R.A. van der; Jonge-Muller, E.S.M. de; Schoonderwoerd, M.J.A.; Paauwe, M.; Vos, T. de; Wit, S. de; Pelt, G.W. van; Mesker, W.E.; Hawinkels, L.J.A.C. & Hardwick, J.C.H. (2020), Bidirectional tumor/stroma crosstalk promotes metastasis in mesenchymal colorectal cancer, Oncogene 39.
- Suerink, M.; Wimmer, K.; Brugieres, L.; Colas, C.; Gallon, R.; Ripperger, T.; Benusiglio, P.R.; Bleiker, E.M.A.; Ghorbanoghli, Z.; Goldberg, Y.; Hardwick, J.C.H.; Kloor, M.; Mentec, M. le; Muleris, M.; Pineda, M.; Ruiz-Ponte, C. & Vasen, H.F.A. (2020), Report of the fifth meeting of the European Consortium 'Care for CMMRD' (C4CMMRD), Leiden, The Netherlands, July 6th 2019, Familial Cancer 20.
- Ouahoud, S.; Hardwick, J.C.H. & Hawinkels, L.J.A.C. (2020), Extracellular BMP antagonists, multifaceted orchestrators in the tumor and its microenvironment, International Journal of Molecular Sciences 21(11).
- Schoonderwoerd, M.J.A.; Koops, M.F.M.; Angela, R.A.; Koolmoes, B.; Toitou, M.; Paauwe, M.; Barnhoorn, M.C.; Liu, Y.M.; Sier, C.F.M.; Hardwick, J.C.H.; Nixon, A.B.; Theuer, C.P.; Fransen, M.F. & Hawinkels, L.J.A.C. (2020), Targeting endoglin-expressing regulatory T cells in the tumor microenvironment enhances the effect of PD1 checkpoint inhibitor immunotherapy, Clinical Cancer Research 26(14): 3831-3842.
- Dekkers, N.; Boonstra, J.J.; Moons, L.M.G.; Hompes, R.; Bastiaansen, B.A.; Tuynman, J.B.; Koch, A.D.; Weusten, B.L.A.M.; Pronk, A.; Neijenhuis, P.A.; Westerterp, M.; Hout, W.B. van den; Langers, A.M.J.; Kraan, J. van der; Alkhalaf, A.; Lai, J.Y.L.; Borg, F. ter; Fabry, H.; Halet, E.; Schwartz, M.P.; Nagengast, W.B.; Straathof, J.W.A.; Hove, R.W.R. ten; Oterdoom, L.H.; Hoff, C.; Belt, E.J.T.; Zimmerman, D.D.E.; Hadithi, M.; Morreau, H.; Cuba, E.M.V. de; Leijtens, J.W.A.; Vasen, H.F.A.; Leerdam, M.E. van; Graaf, E.J.R. de; Doornebosch, P.G. & Hardwick, J.C.H. (2020), Transanal minimally invasive surgery (TAMIS) versus endoscopic submucosal dissection (ESD) for resection of non-pedunculated rectal lesions (TRIASSIC study): study protocol of a European multicenter randomised controlled trial, BMC Gastroenterology 20(1).
- Jongh, S.J. de; Vrouwe, J.P.M.; Voskuil, F.J.; Schmidt, I.; Westerhof, J.; Koornstra, J.J.; Kam, M.L. de; Karrenbeld, A.; Hardwick, J.C.H.; Robinson, D.J.; Burggraaf, J.; Kamerling, I.M.C. & Nagengast, W.B. (2020), The optimal imaging window for dysplastic colorectal polyp detection using c-met-targeted fluorescence molecular endoscopy, Journal of Nuclear Medicine 61(10): 1435-1441.
- Langers, A.M.J.; Boonstra, J.J.; Hardwick, J.C.H.; Kraan, J. van der; Sarasqueta, A.F. & Vasen, H.F.A. (2019), Endoscopic full thickness resection for early colon cancer in Lynch syndrome, Familial Cancer 18(3): 349-352.
- Dang, H.; Cappel, W.H.D.T.N.; Zwaan, S.M.S. van der; Akker-van Marle, M.E. van den; Westreenen, H.L. van; Backes, Y.; Moons, L.M.G.; Holman, F.A.; Peeters, K.C.M.J.; Kraan, J. van der; Langers, A.M.J.; Lijfering, W.M.; Hardwick, J.C.H. & Boonstra, J.J. (2019), Quality of life and fear of cancer recurrence in T1 colorectal cancer patients treated with endoscopic or surgical tumor resection, Gastrointestinal Endoscopy 89(3): 533-544.
- Harryvan, T.J.; Verdegaal, E.M.E.; Hardwick, J.C.H.; Hawinkels, L.J.A.C. & Burg, S.H. van der (2019), Targeting of the Cancer-Associated Fibroblast-T-Cell Axis in Solid Malignancies, Journal of Clinical Medicine 8(11).
- Vasen, H.F.A.; Ghorbanoghli, Z.; Ruijter, B. de; Trinidad, R.A.; Langers, A.M.J.; Peeters, K.C.M.J.; Bonsing, B.A. & Hardwick, J.C.H. (2019), Optimizing the timing of colorectal surgery in patients with familial adenomatous polyposis in clinical practice, Scandinavian Journal of Gastroenterology.
- Jimenez-Martinez, M.; Stale, C.M.; Burg, L.R. van der; Galan-Martinez, J.; Hardwick, J.C.H.; Lopez-Perez, R.; Hawinkels, L.J.A.C.; Stamatakis, K. & Fresno, M. (2019), DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression, Cancers 11(11).
- Haanstra, J.F.; Dekker, E.; Cats, A.; Nagengast, F.M.; Hardwick, J.C.; Vanhoutvin, S.A.; Cappel, W.H.D.T.N.; Vasen, H.F.; Kleibeuker, J.H. & Koornstra, J.J. (2019), Effect of chromoendoscopy in the proximal colon on colorectal neoplasia detection in Lynch syndrome: a multicenter randomized controlled trial, Gastrointestinal Endoscopy 90(4): 624-632.
- Barendse, R.M.; Musters, G.D.; Graaf, E.J.R. de; Broek, F.J.C. van den; Consten, E.C.J.; Doornebosch, P.G.; Hardwick, J.C.; Hingh, I.H.J.T. de; Hoff, C.; Jansen, J.M.; Wit, A.W.M.V. de; Schelling, G.P. van der; Schoon, E.J.; Schwartz, M.P.; Weusten, B.L.A.M.; Dijkgraaf, M.G.; Fockens, P.; Bemelman, W.A.; Dekker, E. & TREND Study Grp (2018), Randomised controlled trial of transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND Study), Gut 67(5): 837-846.
- Buckle, T.; Willigen, D.M. van; Spa, S.J.; Hensbergen, A.W.; Wal, S. van der; Korne, C.M. de; Welling, M.M.; Poel, H.G. van der; Hardwick, J.C.H. & Leeuwen, F.W.B. van (2018), Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer, Journal of Nuclear Medicine 59(6): 986-992.
- Langers, A.M.J.; Bevers, R.F.M.; Boonstra, J.J. & Hardwick, J.C.H. (2018), Successful closure of a chronic vesicorectal fistula after radical prostatectomy with an over-the-scope clip, Endoscopy 50(9): E272-E273.
- Paauwe, M.; Schoonderwoerd, M.J.A.; Helderman, R.F.C.P.; Harryvan, T.J.; Groenewoud, A.; Pelt, G.W. van; Bor, R.; Hemmer, D.M.; Versteeg, H.H.; Snaar-Jagalska, B.E.; Theuer, C.P.; Hardwick, J.C.H.; Sier, C.F.M.; Dijke, P. ten & Hawinkels, L.J.A.C. (2018), Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis, Clinical Cancer Research 24(24): 6331-6344.
- Ghorbanoghli, Z.; Bastiaansen, B.A.J.; Langers, A.M.J.; Nagengast, F.M.; Poley, J.W.; Hardwick, J.C.H.; Koornstra, J.J.; Sanduleanu, S.; Cappel, W.H.D.T.N.; Witteman, B.J.M.; Morreau, H.; Dekker, E. & Vasen, H.F.A. (2018), Extracolonic cancer risk in Dutch patients with APC (adenomatous polyposis coli)-associated polyposis, Journal of Medical Genetics 55(1): 11-14.
- Barendregt, J.; Jong, M. de; Haans, J.J.; Hoek, B. van; Hardwick, J.; Veenendaal, R.; Meulen, A. van der; Srivastava, N.; Stuyt, R. & Maljaars, J. (2017), Liver test abnormalities predict complicated disease behaviour in patients with newly diagnosed Crohn's disease, International Journal of Colorectal Disease 32(4): 459-467.
- Bronsgeest, K.; Huisman, J.F.; Langers, A.; Boonstra, J.J.; Schenk, B.E.; Cappel, W.H.D.T.N.; Vasen, H.F.A. & Hardwick, J.C.H. (2017), Safety of endoscopic mucosal resection (EMR) of large non-pedunculated colorectal adenomas in the elderly, International Journal of Colorectal Disease 32(12): 1711-1717.
- Boonstra, J.J.; Cappel, W.H.D.T.N.; Langers, A.M.J.; Sluis, H. van der; Hardwick, J.H. & Vasen, H.F.A. (2017), Colonoscopy in Lynch syndrome: the need for a new quality score, Familial Cancer 16(2): 239-241.
- Willigen, D.M. van; Berg, N.S. van den; Buckle, T.; KleinJan, G.H.; Hardwick, J.C.; Poel, H.G. van der & Leeuwen, F.W.B. van (2017), Multispectral fluorescence guided surgery; a feasibility study in a phantom using a clinical-grade laparoscopic camera system, American Journal of Nuclear Medicine and Molecular Imaging 7(3): 138-147.
- Voorneveld, P.W.; Reimers, M.S.; Bastiaannet, E.; Jacobs, R.J.; Eijk, R. van; Zanders, M.M.J.; Herings, R.M.C.; Herk-Sukel, M.P.P. van; Kodach, L.L.; Wezel, T. van; Kuppen, P.J.K.; Morreau, H.; Velde, C.J.H.V. de; Hardwick, J.C.H. & Liefers, G.J. (2017), Statin Use After Diagnosis of Colon Cancer and Patient Survival, Gastroenterology 153(2): 470-+.
- Hawinkels, L.J.A.C. & Hardwick, J.C.H. (2017), Putting the Wnt up colon cancer, Gut 66(6): 983-+.
- Paauwe, M.; Heijkants, R.C.; Oudt, C.H.; Pelt, G.W. van; Cui, C.; Theuer, C.P.; Hardwick, J.C.H.; Sier, C.F.M. & Hawinkels, L.J.A.C. (2016), Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer, Oncogene 35(31): 4069-4079.
- Erp, S.J.H. van; Leicher, L.W.; Hennink, S.D.; Ghorbanoghli, Z.; Breg, S.A.C.; Morreau, H.; Nielsen, M.; Hardwick, J.C.H.; Roukema, J.A.; Langers, A.M.J.; Cappel, W.H.D.T.N. & Vasen, H.F.A. (2016), Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: results ofa pilot study, Scandinavian Journal of Gastroenterology 51(10): 1227-1232.
- Backes, Y.; Moons, L.M.G.; Bergeijk, J.D. van; Berk, L.; Borg, F. ter; Borg, P.C.J. ter; Elias, S.G.; Geesing, J.M.J.; Groen, J.N.; Hadithi, M.; Hardwick, J.C.H.; Kerkhof, M.; Mangen, M.J.J.; Straathof, J.W.A.; Schroder, R.; Schwartz, M.P.; Spanier, B.W.M.; Cappel, W.H.D.T.N.; Wolfhagen, F.H.J. & Koch, A.D. (2016), Endoscopic mucosal resection (EMR) versus endoscopic submucosal dissection (ESD) for resection of large distal non-pedunculated colorectal adenomas (MATILDA-trial): rationale and design of a multicenter randomized clinical trial, BMC Gastroenterology 16.
- Handgraaf, H.J.M.; Boogerd, L.S.F.; Verbeek, F.P.R.; Tummers, Q.R.J.G.; Hardwick, J.C.H.; Baeten, C.I.M.; Frangioni, J.V.; Velde, C.J.H. van de & Vahrmeijer, A.L. (2016), Intraoperative fluorescence imaging to localize tumors and sentinel lymph nodes in rectal cancer, Minimally Invasive Therapy and Allied Technologies 25(1): 48-53.
- Voorneveld, P.W.; Kodach, L.L.; Jacobs, R.J.; Noesel, C.J.M. van; Peppelenbosch, M.P.; Korkmaz, K.S.; Molendijk, I.; Dekker, E.; Morreau, H.; Pelt, G.W. van; Tollenaar, R.A.E.M.; Mesker, W.; Hawinkels, L.J.A.C.; Paauwe, M.; Verspaget, H.W.; Geraets, D.T.; Hommes, D.W.; Offerhaus, G.J.A.; Brink, G.R. van den; Dijke, P. ten & Hardwick, J.C.H. (2015), The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC, British Journal of Cancer 112(1): 122-130.
- Voorneveld, P.W.; Jacobs, R.J.; Kodach, L.L. & Hardwick, J.C.H. (2015), A Meta-Analysis of SMAD4 Immunohistochemistry as a Prognostic Marker in Colorectal Cancer, Translational Oncology 8(1): 18-24.
- Hoekstra, E.; Kodach, L.L.; , A.M. das; Ruela-de-Sousa, R.R.; Ferreira, C.V.; Hardwick, J.C.; Woude, C.J. van der; Peppelenbosch, M.P.; Hagen, T.L.M. ten & Fuhler, G.M. (2015), Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer, Oncotarget 6(10): 8300-8312.
- Leeuwen, F.W.B. van; Hardwick, J.C.H. & Erkel, A.R. van (2015), Luminescence-based Imaging Approaches in the Field of Interventional Molecular Imaging, Radiology 276(1): 12-29.
- Burggraaf, J.; Kamerling, I.M.C.; Gordon, P.B.; Schrier, L.; Kam, M.L. de; Kales, A.J.; Bendiksen, R.; Indrevoll, B.; Bjerke, R.M.; Moestue, S.A.; Yazdanfar, S.; Langers, A.M.J.; Swaerd-Nordmo, M.; Torheim, G.; Warren, M.V.; Morreau, H.; Voorneveld, P.W.; Buckle, T.; Leeuwen, F.W.B. van; Odegardstuen, L.I.; Dalsgaard, G.T.; Healey, A. & Hardwick, J.C.H. (2015), Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met, Nature Medicine 21(8): 955-961.
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