James Hardwick
Professor Gastroenterology and Hepatology, in particular the early detection and treatment of colorectal tumours
- Name
- Prof.dr. J.C.H. Hardwick
- Telephone
- +31 71 526 5364
- j.c.h.hardwick@lumc.nl
- ORCID iD
- 0000-0002-9575-5099
James Hardwick is Professor of Gastroenterology and Hepatology, in particular the Early Detection and Treatment of Colorectal Tumours.
More information about James Hardwick
James Hardwick is Professor of Gastroenterology and Hepatology, in particular the Early Detection and Treatment of Colorectal Tumours.
Gastroenterology and Hepatology
Bowel cancer affects one in twenty in the Dutch population and is the most deadly form of cancer after lung cancer. Prof Hardwick is researching new methods of detecting bowel cancer and remove them in an “organ sparing” manner. His research also focusses on unravelling the molecular development of bowel cancer.
Academic career
James Hardwick was educated in Gastroenterology and General Internal Medicine in England. He moved to Amsterdam in 1999 and on the 25th September 2002 received a PhD from the University of Amsterdam with a thesis entitled “Molecular Mechanisms in Colon Cancer”. He left Amsterdam for Leiden in 2007 to continue his research. His areas of research interest are the role of the BMP signalling pathway in the development and progression of bowel cancer, chemoprevention of bowel cancer, new endoscopic techniques to detect bowel cancer precursors and minimally invasive techniques to remove precursors of bowel cancer. He held his inaugural lecture with the title “Colon cancer through the looking glass” on September 18 2015.
Professor Gastroenterology and Hepatology, in particular the early detection and treatment of colorectal tumours
- Faculteit Geneeskunde
- Divisie 2
- Maag-, Darm- en Leverziekten
- Dekkers, N.; Dang, H.; Graaf, M. de; Nobbenhuis, K.; Verhoeven, D.A.; Kraan, J. van der; Cappel, W.H.D.T.N.; Alkhalaf, A.; Westreenen, H.L. van; Basiliya, K.; Peeters, K.C.M.J.; Westerterp, M.; Doornebosch, P.G.; Hardwick, J.C.H.; Langers, A.M.J. & Boonstra, J.J. (2024), T1 colorectal cancer patients' perspective on information provision and therapeutic decision-making after local resection, United European Gastroenterology Journal.
- Verhoeven, D.A.; Moons, L.M.G.; Koch, A.D.; Hardwick, J.C.H.; Boonstra, J.J. & Dang, H. (2024), It's all about time: evaluation of the updated Zhongshan colorectal endoscopic submucosal dissection model in Western endoscopic submucosal dissection practice, Gastrointestinal Endoscopy 99(6): 1076-1078.
- Dang, R.H.; Dekkers, N.; Steyerberg, E.W.; Baldaque-Silva, F.; Omae, M.; Haasnoot, K.J.C.; Tilburg, L. van; Nobbenhuis, K.; Kraan, J. van der; Langers, A.M.J.; Hooft, J.E. van; Graaf, W. de; Koch, A.D.; Didden, P.; Moons, L.M.G.; Hardwick, J.C.H. & Boonstra, J.J. (2023), Predicting procedure duration of colorectal endoscopic submucosal dissection at Western endoscopy centers, Endoscopy International Open 11(08): E724-E732.
- Dang, H.; Harryvan, T.J.; Liao, C.Y.; Danen, E.H.J.; Spalburg, V.N.L.N.; Kielbasa, S.M.; Mei, H.L.; Goeman, J.J.; Jonge-Muller, E.S. de; Janson, S.G.T.; Reijden, J.J. van der; Crobach, S.; Hardwick, J.C.H.; Boonstra, J.J.; Miranda, N.F.C.C. de & Hawinkels, L.J.A.C. (2023), Cancer-associated fibroblasts are key determinants of cancer cell Invasion in the earliest stage of colorectal cancer, Cellular and Molecular Gastroenterology and Hepatology 16(1): 107-131.
- Dang, H.; Dekkers, N.; Steyerberg, E.W.; Baldaque-Silva, F.; Omae, M.; Haasnoot, K.J.C.; Tilburg, L. van; Nobbenhuis, K.; Kraan, J. van der; Langers, A.M.J.; Hooft, J.E. van; Graaf, W. de; Koch, A.D.; Didden, P.; Moons, L.M.G.; Hardwick, J.C.H. & Boonstra, J.J. (2023), Predicting procedure duration of colorectal endoscopic submucosal dissection at Western endoscopy centers (vol 11, pg E724, 2023), Endoscopy International Open 11(8): C5-C5.
- Dekkers, N.; Dang, H.; Vork, K.; Langers, A.M.J.; Kraan, J. van der; Westerterp, M.; Peeters, K.C.M.J.; Holman, F.A.; Koch, A.D.; Graaf, W. de; Didden, P.; Moons, L.M.G.; Doornebosch, P.G.; Hardwick, J.C.H. & Boonstra, J.J. (2023), Outcome of completion surgery after endoscopic submucosal dissection in early-stage colorectal cancer patients, Cancers 15(18).
- Dekkers, N.; Zonoobi, E.; Dang, H.; Warmerdam, M.I.; Crobach, S.; Langers, A.M.J.; Kraan, J. van der; Hilling, D.E.; Peeters, K.C.M.J.; Holman, F.A.; Vahrmeijer, A.L.; Sier, C.F.M.; Hardwick, J.C.H. & Boonstra, J.J. (2023), Colorectal polyps, United European Gastroenterology Journal 11(3).
- Dang, H.; Dekkers, N.; Steyerberg, E.W.; Nobbenhuis, K.; Haasnoot, K.J.; Tilburg, L. van; Kraan, J. van der; Langers, A.M.; Graaf, W. de; Koch, A.D.; Didden, P.; Moons, L.M.G.; Hooft, J.E. van; Hardwick, J. & Boonstra, J. (2022), TIME PLANNING OF COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION AT TERTIARY WESTERN CENTERS: DEVELOPMENT OF A PREDICTION MODEL FOR PROCEDURE DURATION (CESD-TIME FORMULA), Gastrointestinal Endoscopy 95(6): AB62-AB63.
- Roelands, J.; Ploeg, M. van der; Ijsselsteijn, M.E.; Dang, H.; Boonstra, J.J.; Hardwick, J.C.H.; Hawinkels, L.J.A.C.; Morreau, H. & Miranda, N.F.C.C. de (2022), Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis, Gut 72(7).
- Dekkers, N.; Dang, H.; Kraan, J. van der; Cessie, S. le; Oldenburg, P.P.; Schoones, J.W.; Langers, A.M.J.; Leerdam, M.E. van; Hooft, J.E. van; Backes, Y.; Levic, K.; Meining, A.; Saracco, G.M.; Holman, F.A.; Peeters, K.C.M.J.; Moons, L.M.G.; Doornebosch, P.G.; Hardwick, J.C.H. & Boonstra, J.J. (2022), Risk of recurrence after local resection of T1 rectal cancer, Surgical Endoscopy 36.
- Harryvan, T.J.; Visser, M.; Bruin, L. de; Plug, L.; Griffioen, L.; Mulder, A.; Veelen, P.A. van; Noort, G.J.V. van; Jongsma, M.L.; Meeuwsen, M.H.; Wiertz, E.J.; Santegoets, S.J.; Hardwick, J.C.; Hall, T. van; Neefjes, J.; Burg, S.H. van der; Hawinkels, L.J.A.C. & Verdegaal, E.M.E. (2022), Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S, Journal for ImmunoTherapy of Cancer 10(3).
- Dang, H.; Harrijvan, T.J.; Liao, A.; Danen, E.H.; Miranda, N.F. de; Hardwick, J.; Boonstra, J. & Hawinkels, L. (2022), CANCER-ASSOCIATED FIBROBLASTS IN T1 COLORECTAL CANCER PROMOTE MATRIX REMODELING AND TUMOR ORGANOID EXPANSION, Gastroenterology 162(7): S323-S323.
- Dekkers, N.; Dang, H.; Kraan, J. van der; Cessie, S. le; Oldenburg, P.P.; Schoones, J.W.; Langers, A.M.; Leerdam, M. van; Hooft, J.E. van; Backes, Y.; Levic, K.; Meining, A.; Saracco, G.; Holman, F.A.; Peeters, K.; Moons, L.M.G.; Doornebosch, P.G.; Hardwick, J. & Boonstra, J. (2022), RECURRENCE AFTER LOCAL SURGICAL RESECTION OF T1 RECTAL CANCER: A META-ANALYSIS AND COMPARISON WITH ENDOSCOPIC RESECTION, Gastrointestinal Endoscopy 95(6): AB140-AB140.
- Dekkers, N.; Dang, H.; Kraan, J. van der; Cessie, S. le; Oldenburg, P.P.; Schoones, J.W.; Langers, A.M.J.; Leerdam, M.E. van; Hooft, J.E. van; Backes, Y.; Levic, K.; Meining, A.; Saracco, G.M.; Holman, F.A.; Peeters, K.C.M.J.; Moons, L.M.G.; Doornebosch, P.G.; Hardwick, J.C.H. & Boonstra, J.J. (2022), Risk of recurrence after local resection of T1 rectal cancer, Surgical Endoscopy 36(12): 9156-9168.
- Ouahoud, S.; Westendorp, B.F.; Voorneveld, P.W.; Abudukelimu, S.; Koelink, P.J.; Garcia, E.P.; Buuren, J.F.I.; Harryvan, T.J.; Lenos, K.J.; Wezel, T. van; Offerhaus, J.A.; Farina-Sarasqueta, A.; Crobach, S.; Slingerland, M.; Hardwick, J.C.H. & Hawinkels, L.J.A.C. (2022), Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development, Journal of Gastroenterology 58.
- Dang, H.; Dekkers, N.; Cessie, S. le; Hooft, J.E. van; Leerdam, M.E. van; Oldenburg, P.P.; Flothuis, L.; Schoones, J.W.; Langers, A.M.J.; Hardwick, J.C.H.; Kraan, J. van der & Boonstra, J.J. (2022), Risk and time pattern of recurrences after local endoscopic resection of T1 colorectal cancer, Clinical Gastroenterology and Hepatology 20(2).
- Dang, H.; Pelt, G.W. van; Haasnoot, K.J.C.; Backes, Y.; Elias, S.G.; Seerden, T.C.J.; Schwartz, M.P.; Spanier, B.W.M.; Cappel, W.H.D.T.N.; Bergeijk, J.D. van; Kessels, K.; Geesing, J.M.J.; Groen, J.N.; Borg, F. ter; Wolfhagen, F.H.J.; Seldenrijk, C.A.; Raicu, M.G.; Milne, A.N.; Lent, A.U.G. van; Brosens, L.A.A.; Offerhaus, G.J.A.; Siersema, P.D.; Tollenaar, R.A.E.M.; Hardwick, J.C.H.; Hawinkels, L.J.A.C.; Moons, L.M.G.; Lacle, M.M.; Mesker, W.E. & Boonstra, J.J. (2021), Tumour-stroma ratio has poor prognostic value in nonpedunculated T1 colorectal cancer, United European Gastroenterology Journal 9(4).
- Ouahoud, S.; Jacobs, R.J.; Kodach, L.L.; Voorneveld, P.W.; Hawinkels, L.J.A.C.; Weil, N.L.; Vliet, B. van; Herings, R.M.; Burg, L.R.A. van der; Wezel, T. van; Morreau, H.; Slingerland, M.; Bastiaannet, E.; Putter, H. & Hardwick, J.C.H. (2021), Statin use is associated with a reduced incidence of colorectal cancer expressing SMAD4, British Journal of Cancer.
- Hardwick, J.C.H. (2021), Tattoo you?, Endoscopy.
- Chua, J.S.; Dang, H.; Zwager, L.; Dekkers, N.; Hardwick, J.C.H.; Langers, A.M.J.; Kraan, J. van der; Perk, L.E.; Bastiaansen, B.A.J.; Boonstra, J.J. & Dutch eFTR Working Grp (2021), Hybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer, Endoscopy International Open 09(11): E1686-E1691.
- Ouahoud, S.; Jacobs, R.J.; Peppelenbosch, M.P.; Fuhler, G.M.; Heijmans, J.; Diks, S.; Wildenberg, M.E.; Hawinkels, L.J.A.C.; Kodach, L.L.; Voorneveld, P.W. & Hardwick, J.C.H. (2021), Kinome-wide analysis of the effect of statins in colorectal cancer, British Journal of Cancer 124.
- Ouahoud, S.; Jacobs, R.J.; Peppelenbosch, M.P.; Fuhler, G.M.; Heijmans, J.; Diks, S.; Wildenberg, M.E.; Hawinkels, L.J.A.C.; Kodach, L.L.; Voorneveld, P.W. & Hardwick, J.C.H. (2021), Kinome-wide analysis of the effect of statins in colorectal cancer (Mar, 10.1038/s41416-021-01318-9, 2021), British Journal of Cancer 125(1): 144-144.
- Ouahoud, S.; Voorneveld, P.W.; Burg, L.R.A. van der; Jonge-Muller, E.S.M. de; Schoonderwoerd, M.J.A.; Paauwe, M.; Vos, T. de; Wit, S. de; Pelt, G.W. van; Mesker, W.E.; Hawinkels, L.J.A.C. & Hardwick, J.C.H. (2020), Bidirectional tumor/stroma crosstalk promotes metastasis in mesenchymal colorectal cancer, Oncogene 39.
- Ouahoud, S.; Hardwick, J.C.H. & Hawinkels, L.J.A.C. (2020), Extracellular BMP antagonists, multifaceted orchestrators in the tumor and its microenvironment, International Journal of Molecular Sciences 21(11).
- Dekkers, N.; Boonstra, J.J.; Moons, L.M.G.; Hompes, R.; Bastiaansen, B.A.; Tuynman, J.B.; Koch, A.D.; Weusten, B.L.A.M.; Pronk, A.; Neijenhuis, P.A.; Westerterp, M.; Hout, W.B. van den; Langers, A.M.J.; Kraan, J. van der; Alkhalaf, A.; Lai, J.Y.L.; Borg, F. ter; Fabry, H.; Halet, E.; Schwartz, M.P.; Nagengast, W.B.; Straathof, J.W.A.; Hove, R.W.R. ten; Oterdoom, L.H.; Hoff, C.; Belt, E.J.T.; Zimmerman, D.D.E.; Hadithi, M.; Morreau, H.; Cuba, E.M.V. de; Leijtens, J.W.A.; Vasen, H.F.A.; Leerdam, M.E. van; Graaf, E.J.R. de; Doornebosch, P.G. & Hardwick, J.C.H. (2020), Transanal minimally invasive surgery (TAMIS) versus endoscopic submucosal dissection (ESD) for resection of non-pedunculated rectal lesions (TRIASSIC study): study protocol of a European multicenter randomised controlled trial, BMC Gastroenterology 20(1).
- Suerink, M.; Wimmer, K.; Brugieres, L.; Colas, C.; Gallon, R.; Ripperger, T.; Benusiglio, P.R.; Bleiker, E.M.A.; Ghorbanoghli, Z.; Goldberg, Y.; Hardwick, J.C.H.; Kloor, M.; Mentec, M. le; Muleris, M.; Pineda, M.; Ruiz-Ponte, C. & Vasen, H.F.A. (2020), Report of the fifth meeting of the European Consortium 'Care for CMMRD' (C4CMMRD), Leiden, The Netherlands, July 6th 2019, Familial Cancer 20.
- Schoonderwoerd, M.J.A.; Koops, M.F.M.; Angela, R.A.; Koolmoes, B.; Toitou, M.; Paauwe, M.; Barnhoorn, M.C.; Liu, Y.M.; Sier, C.F.M.; Hardwick, J.C.H.; Nixon, A.B.; Theuer, C.P.; Fransen, M.F. & Hawinkels, L.J.A.C. (2020), Targeting endoglin-expressing regulatory T cells in the tumor microenvironment enhances the effect of PD1 checkpoint inhibitor immunotherapy, Clinical Cancer Research 26(14): 3831-3842.
- Jongh, S.J. de; Vrouwe, J.P.M.; Voskuil, F.J.; Schmidt, I.; Westerhof, J.; Koornstra, J.J.; Kam, M.L. de; Karrenbeld, A.; Hardwick, J.C.H.; Robinson, D.J.; Burggraaf, J.; Kamerling, I.M.C. & Nagengast, W.B. (2020), The optimal imaging window for dysplastic colorectal polyp detection using c-met-targeted fluorescence molecular endoscopy, Journal of Nuclear Medicine 61(10): 1435-1441.
- Vasen, H.F.A.; Ghorbanoghli, Z.; Ruijter, B. de; Trinidad, R.A.; Langers, A.M.J.; Peeters, K.C.M.J.; Bonsing, B.A. & Hardwick, J.C.H. (2019), Optimizing the timing of colorectal surgery in patients with familial adenomatous polyposis in clinical practice, Scandinavian Journal of Gastroenterology.
- Langers, A.M.J.; Boonstra, J.J.; Hardwick, J.C.H.; Kraan, J. van der; Sarasqueta, A.F. & Vasen, H.F.A. (2019), Endoscopic full thickness resection for early colon cancer in Lynch syndrome, Familial Cancer 18(3): 349-352.
- Haanstra, J.F.; Dekker, E.; Cats, A.; Nagengast, F.M.; Hardwick, J.C.; Vanhoutvin, S.A.; Cappel, W.H.D.T.N.; Vasen, H.F.; Kleibeuker, J.H. & Koornstra, J.J. (2019), Effect of chromoendoscopy in the proximal colon on colorectal neoplasia detection in Lynch syndrome: a multicenter randomized controlled trial, Gastrointestinal Endoscopy 90(4): 624-632.
- Jimenez-Martinez, M.; Stale, C.M.; Burg, L.R. van der; Galan-Martinez, J.; Hardwick, J.C.H.; Lopez-Perez, R.; Hawinkels, L.J.A.C.; Stamatakis, K. & Fresno, M. (2019), DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression, Cancers 11(11).
- Dang, H.; Cappel, W.H.D.T.N.; Zwaan, S.M.S. van der; Akker-van Marle, M.E. van den; Westreenen, H.L. van; Backes, Y.; Moons, L.M.G.; Holman, F.A.; Peeters, K.C.M.J.; Kraan, J. van der; Langers, A.M.J.; Lijfering, W.M.; Hardwick, J.C.H. & Boonstra, J.J. (2019), Quality of life and fear of cancer recurrence in T1 colorectal cancer patients treated with endoscopic or surgical tumor resection, Gastrointestinal Endoscopy 89(3): 533-544.
- Harryvan, T.J.; Verdegaal, E.M.E.; Hardwick, J.C.H.; Hawinkels, L.J.A.C. & Burg, S.H. van der (2019), Targeting of the Cancer-Associated Fibroblast-T-Cell Axis in Solid Malignancies, Journal of Clinical Medicine 8(11).
- Langers, A.M.J.; Bevers, R.F.M.; Boonstra, J.J. & Hardwick, J.C.H. (2018), Successful closure of a chronic vesicorectal fistula after radical prostatectomy with an over-the-scope clip, Endoscopy 50(9): E272-E273.
- Barendse, R.M.; Musters, G.D.; Graaf, E.J.R. de; Broek, F.J.C. van den; Consten, E.C.J.; Doornebosch, P.G.; Hardwick, J.C.; Hingh, I.H.J.T. de; Hoff, C.; Jansen, J.M.; Wit, A.W.M.V. de; Schelling, G.P. van der; Schoon, E.J.; Schwartz, M.P.; Weusten, B.L.A.M.; Dijkgraaf, M.G.; Fockens, P.; Bemelman, W.A.; Dekker, E. & TREND Study Grp (2018), Randomised controlled trial of transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND Study), Gut 67(5): 837-846.
- Buckle, T.; Willigen, D.M. van; Spa, S.J.; Hensbergen, A.W.; Wal, S. van der; Korne, C.M. de; Welling, M.M.; Poel, H.G. van der; Hardwick, J.C.H. & Leeuwen, F.W.B. van (2018), Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer, Journal of Nuclear Medicine 59(6): 986-992.
- Paauwe, M.; Schoonderwoerd, M.J.A.; Helderman, R.F.C.P.; Harryvan, T.J.; Groenewoud, A.; Pelt, G.W. van; Bor, R.; Hemmer, D.M.; Versteeg, H.H.; Snaar-Jagalska, B.E.; Theuer, C.P.; Hardwick, J.C.H.; Sier, C.F.M.; Dijke, P. ten & Hawinkels, L.J.A.C. (2018), Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis, Clinical Cancer Research 24(24): 6331-6344.
- Ghorbanoghli, Z.; Bastiaansen, B.A.J.; Langers, A.M.J.; Nagengast, F.M.; Poley, J.W.; Hardwick, J.C.H.; Koornstra, J.J.; Sanduleanu, S.; Cappel, W.H.D.T.N.; Witteman, B.J.M.; Morreau, H.; Dekker, E. & Vasen, H.F.A. (2018), Extracolonic cancer risk in Dutch patients with APC (adenomatous polyposis coli)-associated polyposis, Journal of Medical Genetics 55(1): 11-14.
- Hawinkels, L.J.A.C. & Hardwick, J.C.H. (2017), Putting the Wnt up colon cancer, Gut 66(6): 983-+.
- Voorneveld, P.W.; Reimers, M.S.; Bastiaannet, E.; Jacobs, R.J.; Eijk, R. van; Zanders, M.M.J.; Herings, R.M.C.; Herk-Sukel, M.P.P. van; Kodach, L.L.; Wezel, T. van; Kuppen, P.J.K.; Morreau, H.; Velde, C.J.H.V. de; Hardwick, J.C.H. & Liefers, G.J. (2017), Statin Use After Diagnosis of Colon Cancer and Patient Survival, Gastroenterology 153(2): 470-+.
- Barendregt, J.; Jong, M. de; Haans, J.J.; Hoek, B. van; Hardwick, J.; Veenendaal, R.; Meulen, A. van der; Srivastava, N.; Stuyt, R. & Maljaars, J. (2017), Liver test abnormalities predict complicated disease behaviour in patients with newly diagnosed Crohn's disease, International Journal of Colorectal Disease 32(4): 459-467.
- Boonstra, J.J.; Cappel, W.H.D.T.N.; Langers, A.M.J.; Sluis, H. van der; Hardwick, J.H. & Vasen, H.F.A. (2017), Colonoscopy in Lynch syndrome: the need for a new quality score, Familial Cancer 16(2): 239-241.
- Willigen, D.M. van; Berg, N.S. van den; Buckle, T.; KleinJan, G.H.; Hardwick, J.C.; Poel, H.G. van der & Leeuwen, F.W.B. van (2017), Multispectral fluorescence guided surgery; a feasibility study in a phantom using a clinical-grade laparoscopic camera system, American Journal of Nuclear Medicine and Molecular Imaging 7(3): 138-147.
- Bronsgeest, K.; Huisman, J.F.; Langers, A.; Boonstra, J.J.; Schenk, B.E.; Cappel, W.H.D.T.N.; Vasen, H.F.A. & Hardwick, J.C.H. (2017), Safety of endoscopic mucosal resection (EMR) of large non-pedunculated colorectal adenomas in the elderly, International Journal of Colorectal Disease 32(12): 1711-1717.
- Handgraaf, H.J.M.; Boogerd, L.S.F.; Verbeek, F.P.R.; Tummers, Q.R.J.G.; Hardwick, J.C.H.; Baeten, C.I.M.; Frangioni, J.V.; Velde, C.J.H. van de & Vahrmeijer, A.L. (2016), Intraoperative fluorescence imaging to localize tumors and sentinel lymph nodes in rectal cancer, Minimally Invasive Therapy and Allied Technologies 25(1): 48-53.
- Paauwe, M.; Heijkants, R.C.; Oudt, C.H.; Pelt, G.W. van; Cui, C.; Theuer, C.P.; Hardwick, J.C.H.; Sier, C.F.M. & Hawinkels, L.J.A.C. (2016), Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer, Oncogene 35(31): 4069-4079.
- Erp, S.J.H. van; Leicher, L.W.; Hennink, S.D.; Ghorbanoghli, Z.; Breg, S.A.C.; Morreau, H.; Nielsen, M.; Hardwick, J.C.H.; Roukema, J.A.; Langers, A.M.J.; Cappel, W.H.D.T.N. & Vasen, H.F.A. (2016), Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: results ofa pilot study, Scandinavian Journal of Gastroenterology 51(10): 1227-1232.
- Backes, Y.; Moons, L.M.G.; Bergeijk, J.D. van; Berk, L.; Borg, F. ter; Borg, P.C.J. ter; Elias, S.G.; Geesing, J.M.J.; Groen, J.N.; Hadithi, M.; Hardwick, J.C.H.; Kerkhof, M.; Mangen, M.J.J.; Straathof, J.W.A.; Schroder, R.; Schwartz, M.P.; Spanier, B.W.M.; Cappel, W.H.D.T.N.; Wolfhagen, F.H.J. & Koch, A.D. (2016), Endoscopic mucosal resection (EMR) versus endoscopic submucosal dissection (ESD) for resection of large distal non-pedunculated colorectal adenomas (MATILDA-trial): rationale and design of a multicenter randomized clinical trial, BMC Gastroenterology 16.
- Hoekstra, E.; Kodach, L.L.; , A.M. das; Ruela-de-Sousa, R.R.; Ferreira, C.V.; Hardwick, J.C.; Woude, C.J. van der; Peppelenbosch, M.P.; Hagen, T.L.M. ten & Fuhler, G.M. (2015), Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer, Oncotarget 6(10): 8300-8312.
- Leeuwen, F.W.B. van; Hardwick, J.C.H. & Erkel, A.R. van (2015), Luminescence-based Imaging Approaches in the Field of Interventional Molecular Imaging, Radiology 276(1): 12-29.
- Burggraaf, J.; Kamerling, I.M.C.; Gordon, P.B.; Schrier, L.; Kam, M.L. de; Kales, A.J.; Bendiksen, R.; Indrevoll, B.; Bjerke, R.M.; Moestue, S.A.; Yazdanfar, S.; Langers, A.M.J.; Swaerd-Nordmo, M.; Torheim, G.; Warren, M.V.; Morreau, H.; Voorneveld, P.W.; Buckle, T.; Leeuwen, F.W.B. van; Odegardstuen, L.I.; Dalsgaard, G.T.; Healey, A. & Hardwick, J.C.H. (2015), Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met, Nature Medicine 21(8): 955-961.
- Voorneveld, P.W.; Jacobs, R.J.; Kodach, L.L. & Hardwick, J.C.H. (2015), A Meta-Analysis of SMAD4 Immunohistochemistry as a Prognostic Marker in Colorectal Cancer, Translational Oncology 8(1): 18-24.
- Voorneveld, P.W.; Kodach, L.L.; Jacobs, R.J.; Noesel, C.J.M. van; Peppelenbosch, M.P.; Korkmaz, K.S.; Molendijk, I.; Dekker, E.; Morreau, H.; Pelt, G.W. van; Tollenaar, R.A.E.M.; Mesker, W.; Hawinkels, L.J.A.C.; Paauwe, M.; Verspaget, H.W.; Geraets, D.T.; Hommes, D.W.; Offerhaus, G.J.A.; Brink, G.R. van den; Dijke, P. ten & Hardwick, J.C.H. (2015), The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC, British Journal of Cancer 112(1): 122-130.
- Nicolai, M.P.J.; Keller, J.J.; Vries, L. de; Meulen-de Jong, A.E. van der; Nicolai, J.J.; Hardwick, J.C.H.; Putter, H.; Pelger, R.C.M. & Elzevier, H.W. (2014), The Impact of Sexual Abuse in Patients Undergoing Colonoscopy, PLoS ONE 9(1).
- Heijmans, J.; Wielenga, M.C.B.; Rosekrans, S.L.; Jeude, J.F.V. de; Roelofs, J.; Groothuis, P.; Ederveen, A.; Jonge-Muller, E.S.M. de; Biemond, I.; Hardwick, J.C.H.; D'Haens, G.; Hommes, D.W.; Muncan, V. & Brink, G.R. van den (2014), Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer, Gut 63(2): 310-316.
- Schaik, T. van; Maljaars, J.P.W.; Roopram, R.K.; Verwey, M.H.; Ipenburg, N.; Hardwick, J.C.H.; Veenendaal, R.A. & Meulen-de Jong, A.E. van der (2014), Influence of Combination Therapy with Immune Modulators on Anti-TNF Trough Levels and Antibodies in Patients with IBD, Inflammatory Bowel Diseases 20(12): 2292-2298.
- Voorneveld, P.W.; Kodach, L.L.; Jacobs, R.J.; Liv, N.; Zonnevylle, A.C.; Hoogenboom, J.P.; Biemond, I.; Verspaget, H.W.; Hommes, D.W.; Rooij, K. de; Noesel, C.J.M. van; Morreau, H.; Wezel, T. van; Offerhaus, G.J.A.; Brink, G.R. van den; Peppelenbosch, M.P.; Dijke, P. ten & Hardwick, J.C.H. (2014), Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK, Gastroenterology 147(1): 196-U328.
- Heijmans, J.; Buller, N.V.J.A.; Hoff, E.; Dihal, A.A.; Poll, T. van der; Zoelen, M.A.D. van; Bierhaus, A.; Biemond, I.; Hardwick, J.C.H.; Hommes, D.W.; Muncan, V. & Brink, G.R. van den (2013), Rage signalling promotes intestinal tumourigenesis, Oncogene 32(9): 1202-1206.
- Hennink, S.D.; Hofland, N.; Gopie, J.P.; Kaa, C. van der; Koning, K. de; Nielsen, M.; Tops, C.; Morreau, H.; Cappel, W.H.D.T.N.; Langers, A.M.J.; Hardwick, J.C.; Gaarenstroom, K.N.; Tollenaar, R.A.; Veenendaal, R.A.; Tibben, A.; Wijnen, J.; Heck, M. van; Asperen, C. van; Roukema, A.J.; Hommes, D.W.; Hes, F.J. & Vasen, H.F.A. (2013), Value-based healthcare in Lynch syndrome, Familial Cancer 12(2): 347-354.
- Stolwijk, J.A.M.; Langers, A.M.J.; Hardwick, J.C.; Veenendaal, R.A.; Verspaget, H.W.; Hogezand, R.A. van; Vasen, H.F. & Meulen-de Jong, A.E. van der (2013), A Thirty-Year Follow-Up Surveillance Study for Neoplasia of a Dutch Ulcerative Colitis Cohort, Scientific World Journal.
- Heijmans, J.; Jeude, J.F.V. de; Koo, B.K.; Rosekrans, S.L.; Wielenga, M.C.B.; Wetering, M. van de; Ferrante, M.; Lee, A.S.; Onderwater, J.J.M.; Paton, J.C.; Paton, A.W.; Mommaas, A.M.; Kodach, L.L.; Hardwick, J.C.; Hommes, D.W.; Clevers, H.; Muncan, V. & Brink, G.R. van den (2013), ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response, Cell Reports 3(4): 1128-1139.
- Voorneveld, P.W.; Stache, V.; Jacobs, R.J.; Smolders, E.; Sitters, A.I.; Liesker, A.; Korkmaz, K.S.; Lam, S.M.; Miranda, N.F.C.C. de; Morreau, H.; Kodach, L.L. & Hardwick, J.C.H. (2013), Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis, British Journal of Cancer 109(7): 1805-1812.
- Dop, W.A. van; Rosekrans, S.L.; Uhmann, A.; Jaks, V.; Offerhaus, G.J.A.; Weerman, M.A.V.; Kasper, M.; Heijmans, J.; Hardwick, J.C.H.; Verspaget, H.W.; Hommes, D.W.; Toftgard, R.; Hahn, H. & Brink, G.R. van den (2013), Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus, Gut 62(3): 348-357.
- Voorneveld, P.W.; Jacobs, R.J.; Miranda, N.F.C.C. de; Morreau, H.; Noesel, C.J.M. van; Offerhaus, G.J.A.; Kodach, L.L. & Hardwick, J.C.H. (2013), Evaluation of the prognostic value of pSMAD immunohistochemistry in colorectal cancer, European Journal of Cancer Prevention 22(5): 420-424.
- Liv, N.; Zonnevylle, A.C.; Narvaez, A.C.; Effting, A.P.J.; Voorneveld, P.W.; Lucas, M.S.; Hardwick, J.C.; Wepf, R.A.; Kruit, P. & Hoogenboom, J.P. (2013), Simultaneous Correlative Scanning Electron and High-NA Fluorescence Microscopy, PLoS ONE 8(2): -.
- Baan, B.; Dihal, A.A.; Hoff, E.; Bos, C.L.; Voorneveld, P.W.; Koelink, P.J.; Wildenberg, M.E.; Muncan, V.; Heijmans, J.; Verspaget, H.W.; Richel, D.J.; Hardwick, J.C.H.; Hommes, D.W.; Peppelenbosch, M.P. & Brink, G.R. van den (2012), 5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer, Gut 61(12): 1708-1715.
- Langers, A.M.J.; Verspaget, H.W.; Hawinkels, L.J.A.C.; Kubben, F.J.G.M.; Duijn, W. van; Reijden, J.J. van der; Hardwick, J.C.H.; Hommes, D.W. & Sier, C.F.M. (2012), MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients, British Journal of Cancer 106(9): 1495-1498.
- Jacobs, R.J.; Voorneveld, P.W.; Kodach, L.L. & Hardwick, J.C.H. (2012), Cholesterol metabolism and colorectal cancers, Current Opinion in Pharmacology 12(6): 690-695.
- Muncan, V.; Heijmans, J.; Krasinski, S.D.; Buller, N.V.; Wildenberg, M.E.; Meisner, S.; Radonjic, M.; Stapleton, K.A.; Lamers, W.H.; Biemond, I.; Weerman, M.A.V.; O'Carroll, D.; Hardwick, J.C.; Hommes, D.W. & Brink, G.R. van den (2011), Blimp1 regulates the transition of neonatal to adult intestinal epithelium, Nature Communications 2.
- Heijmans, J.; Muncan, V.; Jacobs, R.J.; Jonge-Muller, E.S.M. de; Graven, L.; Biemond, I.; Ederveen, A.G.; Groothuis, P.G.; Mosselman, S.; Hardwick, J.C.; Hommes, D.W. & Brink, G.R. van den (2011), Intestinal Tumorigenesis Is Not Affected by Progesterone Signaling in Rodent Models, PLoS ONE 6(7).
- Jacobs, R.J.; Kodach, L.L. & Hardwick, J.C.H. (2011), The Potential of Statins for Individualized Colorectal Cancer Chemoprevention, Current Drug Targets 12(13): 1903-1908.
- Kodach, L.L.; Jacobs, R.J.; Voorneveld, P.W.; Wildenberg, M.E.; Verspaget, H.W.; Wezel, T. van; Morreau, H.; Hommes, D.W.; Peppelenbosch, M.P.; Brink, G.R. van den & Hardwick, J.C.H. (2011), Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway, Gut 60(11): 1544-1553.
- Dop, W.A. van; Heijmans, J.; Buller, N.V.J.A.; Snoek, S.A.; Rosekrans, S.L.; Wassenberg, E.A.; Weerman, M.A.V.; Lanske, B.; Clarke, A.R.; Winton, D.J.; Wijgerde, M.; Offerhaus, G.J.; Hommes, D.W.; Hardwick, J.C.; Jonge, W.J. de; Biemond, I. & Brink, G.R. van den (2010), Loss of Indian Hedgehog Activates Multiple Aspects of a Wound Healing Response in the Mouse Intestine, Gastroenterology 139(5): 1665+.
- Kodach, L.L.; Jacobs, R.J.; Heijmans, J.; Noesel, C.J.M. van; Langers, A.M.J.; Verspaget, H.W.; Hommes, D.W.; Offerhaus, G.J.A.; Brink, G.R. van den & Hardwick, J.C.H. (2010), The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer, Carcinogenesis 31(9): 1567-1575.
- Vasen, H.F.A.; Abdirahman, M.; Brohet, R.; Langers, A.M.J.; Kleibeuker, J.H.; Kouwen, M. van; Koornstra, J.J.; Boot, H.; Cats, A.; Dekker, E.; Sanduleanu, S.; Poley, J.W.; Hardwick, J.C.H.; Cappel, W.H.D.T.; Meulen-de Jong,AE van der; Tan, T.G.; Jacobs, M.A.J.M.; Mohamed, F.L.A.; Boer, S.Y. de; Meeberg, P.C. van de; Verhulst, M.L.; Salemans, J.M.; Bentem, N. van; Westerveld, B.D.; Vecht, J. & Nagengast, F.M. (2010), One to 2-Year Surveillance Intervals Reduce Risk of Colorectal Cancer in Families With Lynch Syndrome, Gastroenterology 138(7): 2300-2306.
- Dop, W.A. van; Marengo, S.; Velde, A.A. te; Ciraolo, E.; Franco, I.; Kate, F.J. ten; Boeckxstaens, G.E.; Hardwick, J.C.; Hommes, D.W.; Hirsch, E. & Brink, G.R. van den (2010), The absence of functional PI3K gamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice, Immunology Letters 131(1): 33-39.
- van der Marel S, Duijvestein M, Hardwick JC, van den Brink GR, Veenendaal R, Hommes DW & Fidder HH (2009), Quality of Web-based Information on Inflammatory Bowel Diseases, Inflammatory Bowel Diseases 15(12): 1891-1896.
- van Dop WA, Uhmann A, Wijgerde M, Sleddens-Linkels E, Heijmans J, Offerhaus GJ, Weerman MAV, Boeckxstaens GE, Hommes DW, Hardwick JC, Hahn H & van den Brink GR (2009), Depletion of the Colonic Epithelial Precursor Cell Compartment Upon Conditional Activation of the Hedgehog Pathway, Gastroenterology 136(7): 2195-2203.
- Langers AMJ, Cappell WHD, Veenendaal RA, Bonsing BA, Hardwick JCH & Vasen HFA (2008), Double balloon endoscopy for detection of small-bowel adenomas in familial adenomatous polyposis after pancreaticoduodenectomy according to Whipple, Endoscopy 40(9).
- Hardwick JC, Kodach LL, Offerhaus GJ & van den Brink GR (2008), Bone morphogenetic protein signalling in colorectal cancer, Nature Reviews Cancer 8(10).
- Kodach LL, Bleurning SA, Musler AR, Peppelenbosch MR, Hommes DW, van Den Brink GR, van Noesel CJM, Offerhaus GJA & Hardwick JCH (2008), The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer, Cancer 112(2).
- Kodach LL, Wiercinska E, De Miranda NFCC, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, Van Noesel CJM, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJA & Hardwick JCH (2008), The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers, Gastroenterology 134(5).
- Kodach LL, Bleuming SA, Peppelenbosch MP, Hommes DW, Van Den Brink GR & Hardwick JCH (2007), The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway, Gastroenterology 133(4).
- Bleuming SA, He XC, Kodach LL, Hardwick JC, Koopman FA, ten Kate FJ, van Deventer SJH, Hommes DW, Peppelenbosch MP, Offerhaus GJ, Li LH & van den Brink GR (2007), Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice, Cancer Research 67(17).
- MIKKELSEN EO, THASTRUP O & CHRISTENSEN SB (1988), EFFECTS OF THAPSIGARGIN IN ISOLATED RAT THORACIC AORTA, Pharmacology and Toxicology -Copenhagen- 62(1): 7-11.