Han de Winde
Professor Molecular and Industrial Biotechnology Director ad interim, Leiden Learning and Innovation Centre, LLInC
- Name
- Prof.dr. J.H. de Winde
- Telephone
- +31 71 527 1036
- j.h.de.winde@science.leidenuniv.nl
- ORCID iD
- 0000-0002-7999-9317
Han de Winde is professor in Industrial Biotechnology at Leiden University. Thorough expertise in microbial molecular biotechnology and systems biology research and education at BSc, MSc, PhD and advanced level. In combination with integral management of research, development and education; including effective HRM, budget responsibility, strategy development.
More information about Han de Winde
PhD Candidates
News
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'One in five bacteria we tested were capable of breaking down plastic' -
Three awarded research projects in NWO-XS call -
PhD candidate from Leiden presents international student event -
Leiden students brew coasters from beer waste -
Philip Spinhoven acting Scientific Director Institute of Psychology -
Bacteria that degrade plastic: Unilever Research Prize for master’s student Jo-Anne Verschoor -
Leiden students win grand prize at iGEM international biology competition -
Leiden alternative to plastic microparticles wins second prize in European student competition -
Academic year Biology starts with 2020 pieces less litter -
Faculty of Science opens academic year with live stream in homely setting -
Student team invents Suckerspheres: sustainable alternative for microplastic
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Leiden iGEM team wants to build a kit to diagnose infectious diseases -
NGL presents: biweekly lectures on Corona -
Lisa Bruil receives Kees Bakker Award -
Parade of creative science communication products -
Biology student wins Young Talent graduation prize for Plant Sciences -
Student team hopes to heal skin with squid protein -
Student team iGEM Leiden wins gold in Boston -
Bart de Smit Vice Dean Faculty of Science -
Decomposing tears in order to detect Dry Eye Disease -
Han de Winde steps down as vice-dean of Faculty of Science -
Students hunting for breakthrough in antibiotics resistance -
Fifty Shades of Stress -
International students meet the Faculty of Science
Courses
Former PhD candidates
Former Postdocs
Research
Current research focusses on important aspects of molecular and microbial industrial biotechnology, including elucidation of control of nutrient signalling in baker’s yeast Saccharomyces cerevisiae, novel enzyme discovery and biocatalysis for degradation of plastics and other recalcitrant polymers in fungi and bacteria, and on molecular mechanisms and cell factory approaches of stress and solvent tolerance in Pseudomonas putida as a promising host microbe for industrial biotechnology.
Expertise
Han de Winde has thorough expertise in integral management of research, development and education at BSc, MSc, PhD and advanced level, including effective HRM, budget responsibility and strategy development. His scientific expertise is in microbial molecular genetics and metabolic engineering, specifically in the area of nutrient- and environment-induced signal transduction and control of physiology, growth and development of bacteria, yeast and fungi. He is expert in implementation and development of applied and integrated genomics and systems biology in microbial strain and process improvement. He is author of over 85 peer reviewed scientific publications and of 10 filed patent series.
Short biography
Han de Winde obtained an MSc in organic chemistry and biochemistry at the Vrije Universiteit of Amsterdam and obtained a PhD in molecular biology in 1992 at the University of Amsterdam, The Netherlands. He was NWO (Netherlands Science Foundation) postdoctoral research fellow at the Amsterdam BioCenter, and EU-HCM fellow and assistant professor at the Laboratory of Molecular Cell Biology, Catholic University of Leuven, Belgium. In 2000 he was appointed Senior Scientist Genetics & Physiology at DSM Bakery Ingredients. In 2002 he was appointed part-time full professor in Industrial Genomics, at TU Delft. In 2004 he was appointed Principal Scientist Microbial Genetics and Physiology at DSM Food Specialties RD&T, covering both business unit- and corporate R&D-strategy and responsibilities.
In 2006 Han was appointed Scientific Director and full professor in Genetics and Genomics of Industrial Microorganisms at the Department of Biotechnology, TU Delft. He was business director of the Kluyver Center for Genomics of Industrial Fermentation (NWO-NGI Centre of Excellence), and scientific director of the Delft Research Centre for Life Science and Technology (DRC-LST), and of the Graduate Research School 'Biotechnological Sciences Delft-Leiden' (BSDL). Since 2010 he was deputy dean of the Faculty of Applied Sciences of TU Delft. In 2010 Han was appointed as chairman of the Executive Board of Advanced Chemical Technologies for Sustainability (ACTS), a strategic alliance of the Dutch National Science Foundation NWO. NWO-ACTS was transformed in 2012 into a Knowledge and Innovation Consortium for New Chemical Innovations (TKI-NCI) under auspices of NWO. Han has been chairman of the Program Board of TKI-NCI from the start until 2018. In addition, from 2010-2018 he was vice-chairman of the Chemistry Board of NWO (NWO-CW).
In 2013 Han de Winde was appointed Vice Dean at the Faculty of Sciences, Leiden University. As a vice dean he was responsible for the quality and availability of all education programs of the Faculty of Science. His main focus was on improving and maintaining education quality by evidence-based measures, through continued professionalization of all education staff and by implementing novel concepts enabled through ict-in-education methodology. After two terms as Vice Dean, in early 2019 he resumed the position of chairholder and PI of Molecular and Industrial Biotechnology and was appointed Director of Education at the Leiden Institute of Biology. Currently, Han is Director ad interim of the newly launched Leiden Learning and Innovation Centre LLInC.
Professor Molecular and Industrial Biotechnology Director ad interim, Leiden Learning and Innovation Centre, LLInC
- Science
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Verschoor J., Croese M.R.J., Lakemeier S.E., Mugge A., Burgers C.M.C., Innocenti P., Willemse J.J., Crooijmans M.E., Wezel G.P. van, Ram A.F.J. & Winde J.H. de (2024), Polyester degradation by soil bacteria: identification of conserved BHETase enzymes in Streptomyces, Communications Biology 7: 725.
- Seekles S.J., Brule T. van den, Punt M., Dijksterhuis J., Arentshorst M., Ljadpanahsaravj M., Roseboom W., Meuken G., Ongenae V.M.A., Zwerus J., Ohm R.A., Kramer G.J., Wösten H.A.B., Winde J.H. de & Ram A.F.J. (2023), Compatible solutes determine the heat resistance of conidia, Fungal Biology and Biotechnology 10: 21.
- Verschoor J.A., Kusumawardhani H., Ram A.F.J. & Winde J.H. de (2022), Toward microbial recycling and upcycling of plastics: prospects and challenges, Frontiers in Microbiology 13: 821629.
- Kusumawardhani H., Furtwängler B., Blommestijn M., Kaltenytė A., Poel J.J.A. van der, Kolk J., Hosseini R. & Winde J.H. de (2021), Adaptive laboratory evolution restores solvent tolerance in plasmid-cured Pseudomonas putida S12: a molecular analysis, Applied and Environmental Microbiology 87(9): e00041-21.
- Crooijmans M.E., Delzenne T.O., Hensen T., Darehei M., Winde J.H. de & Heusden G.P.H. van (2021), Cell-to-cell heterogeneity of phosphate gene expression in yeast is controlled by alternative transcription, 14-3-3 and Spl2, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1864(6-7): 194714.
- Brink M. van den, Tandar S.T., Akker T.A.P. van den, Jovikj S., Defourt V., Langelaar T.G.B., Delzenne T.O., Strien K. van, Schonk A.W., Beers A.J.A.M., Golov E., Chong L.J., Bergman G.Ö., Meijdam J.J.W.D. Crooijmans M.E., Claessen D. & Winde J.H. de (2020), Rapidemic, a versatile and label-free DNAzyme-based platform for visual nucleic acid detection. bioRxiv. [working paper].
- Kusumawardhani H., Dijk D., Hosseini R. & Winde J.H. de (2020), Novel toxin-antitoxin module slvT-slvA regulates megaplasmid stability and incites solvent tolerance in Pseudomonas putida S12, Applied and Environmental Microbiology 86(13): e00686-20.
- Kusumawardhani H., Hosseini R. & Winde J.H. de (2020), Comparative analysis reveals the modular functional build-up of megaplasmid pTTS12 of Pseudomonas putida S12: a paradigm for transferable traits, plasmid stability and inheritance?. bioRxiv. [working paper].
- Kusumawardhani H., Hosseini R. & Winde J.H. de (2018), Solvent Tolerance in Bacteria: Fulfilling the Promise of the Biotech Era?, Trends in Biotechnology 36(10): 1025-1039.
- Hosseini R., Kuepper J., Koebbing S., Blank L.M., Wierckx N. & Winde J.H. de (2017), Regulation of solvent tolerance in Pseudomonas putida S12 mediated by mobile elements, Microbial biotechnology 10(6): 1558–1568.
- Volkers R.J.M., Snoek L.B., Ruijssenaars H.J. & Winde J.H. de. (2015), Dynamic Response of Pseudomonas putida S12 to Sudden Addition of Toluene and the Potential Role of the Solvent Tolerance Gene trgI, 10(7): e0132416.
- Kuepper J., Ruijssenaars H.J., Blank L.M., Winde J.H. de & Wierckx N. (2015), Complete genome sequence of solvent-tolerant Pseudomonas putida S12 including megaplasmid pTTS12, Journal of Biotechnology 200: 17-18.
- Flipse S.M., Winde J.H. de., Osseweijer P. & Sanden M.C.A. van der (2014), The wicked problem of Socially Responsible Innovation, EMBO Reports 15(5): 464-464.
- Verhoef S., Gao N., Ruijssenaars H.J. & Winde J.H. de (2014), Crude glycerol as feedstock for the sustainable production of p-hydroxybenzoate by Pseudomonas putida S12, New Biotechnology 31(1): 114-119.
- Flipse S.M., Sanden M.C.A. van der, Radstake M., Winde J.H. de. & Osseweijer P. (2014), The DNA of socially responsible innovation, EMBO Reports 15(2): 134-137.
- Toone E. & Winde J.H. de (2013), Energy biotechnology in 2013: advanced technology development for breakthroughs in fuels and chemicals production, Current Opinion in Biotechnology 24(3): 367-368.
- Li Y. & Winde J.H. de (2013), Systems and synthetic approaches to industrial biotechnology, Biotechnology Journal 8(8): 870-871.
- Bandounas L., Pinkse M., Winde J.H. de & Ruijssenaars H.J. (2013), Identification of a quinone dehydrogenase from a Bacillus sp involved in the decolourization of the lignin-model dye, Azure B, New Biotechnology 30(2): 196-204.
- Meijnen J.P., Winde J.H.de & Ruijssenaars H.J. (2012), Metabolic and Regulatory Rearrangements Underlying Efficient D-Xylose Utilization in Engineered Pseudomonas putida S12, Journal of Biological Chemistry 287(18): 14606-14614.
- Boender L.G.M., Almering M.J.H., Dijk M., Maris A.J.A. van, Winde J.H. de, Pronk J.T. & Daran-Lapujade P. (2011), Extreme calorie restriction and energy source starvation in Saccharomyces cerevisiae represent distinct physiological states, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813(12): 2133-2144.
- Boender L.G.M., Maris A.J.A. van, Hulster E.A.F. de, Almering M.J.H., Klei I.J. van der, Veenhuis M., Winde J.H. de, Pronk J.T. & Daran-Lapujade P. (2011), Cellular responses of Saccharomyces cerevisiae at near-zero growth rates: transcriptome analysis of anaerobic retentostat cultures, FEMS Yeast Research 11(8): 603-620.
- Meijnen J.P., Verhoef S., Briedjlal A.A., Winde J.H. de & Ruijssenaars H.J. (2011), Improved p-hydroxybenzoate production by engineered Pseudomonas putida S12 by using a mixed-substrate feeding strategy, Applied Microbiology and Biotechnology 90(3): 885-893.
- Bandounas L., Wierckx N.J.P., Winde J.H. de & Ruijssenaars H.J. (2011), Isolation and characterization of novel bacterial strains exhibiting ligninolytic potential, BMC Biotechnology 11: 94.
- Meijnen J.P., Winde J.H. de & Ruijssenaars H.J. (2011), Sustainable production of fine chemicals by the solvent-tolerant Pseudomonas putida S12 using lignocellulosic feedstock, International Sugar Journal 113(1345): 24-30.
- Bandounas L., Ballerstedt H., Winde J.H. de & Ruijssenaars H.J. (2011), Redundancy in putrescine catabolism in solvent tolerant Pseudomonas putida S12, Journal of Biotechnology 154(1): 1-10.
- Wierckx N., Koopman F., Ruijssenaars H.J. & Winde J.H. de (2011), Microbial degradation of furanic compounds: biochemistry, genetics, and impact, Applied Microbiology and Biotechnology 92(6): 1095-1105.
- Verhoef S., Ballerstedt H., Volkers R.J.M., Winde J.H. de & Ruijssenaars H.J. (2010), Comparative transcriptomics and proteomics of p-hydroxybenzoate producing Pseudomonas putida S12: novel responses and implications for strain improvement, Applied Microbiology and Biotechnology 87(2): 679-690.
- Koopman F., Wierckx N., Winde J.H. de. & Ruijssenaars H.J. (2010), Efficient whole-cell biotransformation of 5-(hydroxymethyl)furfural into FDCA, 2,5-furandicarboxylic acid, Bioresource Technology 101(16): 6291-6296.
- Wierckx N., Koopman F., Bandounas L., Winde J.H. de & Ruijssenaars H.J. (2010), Isolation and characterization of Cupriavidus basilensis HMF14 for biological removal of inhibitors from lignocellulosic hydrolysate, Microbial biotechnology 3(3): 336-343.
- Volkers R.J.M., Ballerstedt H., Winde J.H. de & Ruijssenaars H.J. (2010), Isolation and genetic characterization of an improved benzene-tolerant mutant of Pseudomonas putida S12, Environmental Microbiology Reports 2(3): 456-460.
- Koopman F., Wierckx N., Winde J.H. de & Ruijssenaars H.J. (2010), Identification and characterization of the furfural and 5-(hydroxymethyl)furfural degradation pathways of Cupriavidus basilensis HMF14, Proceedings of the National Academy of Sciences 107(11): 4919-4924.
- Eunen K. van, Bouwman J., Daran-Lapujade P., Postmus J., Canelas A.B., Mensonides F.I.C., Orij R., Tuzun I., Brink J. van den, Smits G.J., Gulik W.M. van, Brul S., Heijnen J.J., Winde J.H. de, Mattos M.J.T de, Kettner C., Nielsen J., Westerhoff H.V. & Bakker B.M. (2010), Measuring enzyme activities under standardized in vivo-like conditions for systems biology, FEBS Journal 277(3): 749-760.
- Canelas A.B., Harrison N., Fazio A., Zhang J., Pitkanen J.-P., Brink J. van den, Bakker B.M., Bogner L., Bouwman J., Castrillo J.I., Cankorur A., Chumnanpuen P., Daran-Lapujade P., Dikicioglu D., Eunen K. van, Ewald J.C., Heijnen J.J., Kirdar B., Mattila I., Mensonides F.I.C., Niebel A., Penttila M., Pronk J.T., Reuss M., Salusjarvi L., Sauer U., Sherman D., Siemann-Herzberg M., Westerhoff H., Winde J.H. de, Petranovic D., Oliver S.G., Workman C.T., Zamboni N. & Nielsen J. (2010), Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains, Nature Communications 1: 145.
- Meijnen J.P., Winde J.H. de. & Ruijssenaars H.J. (2009), Establishment of Oxidative D-Xylose Metabolism in Pseudomonas putida S12, Applied and Environmental Microbiology 75(9): 2784-2791.
- Verhoef S., Wierckx N., Westerhof R.G.M., Winde J.H. de & Ruijssenaars H.J. (2009), Bioproduction of p-Hydroxystyrene from Glucose by the Solvent-Tolerant Bacterium Pseudomonas putida S12 in a Two-Phase Water-Decanol Fermentation, Applied and Environmental Microbiology 75(4): 931-936.
- Koopman F.W., Winde J.H.de & Ruijssenaars H.J. (2009), C-1 compounds as auxiliary substrate for engineered Pseudomonas putida S12, Applied Microbiology and Biotechnology 83(4): 705-713.
- Brink J. van den, Akeroyd M., Hoeven R. van der, Pronk J.T., Winde J.H. de & Daran-Lapujade P. (2009), Energetic limits to metabolic flexibility: responses of Saccharomyces cerevisiae to glucose-galactose transitions, Microbiology 155: 1340-1350.
- Volkers R.J.M., Ballerstedt H., Ruijssenaars H., Bont J.A.M. de, Winde J.H. de & Wery J. (2009), TrgI, toluene repressed gene I, a novel gene involved in toluene-tolerance in Pseudomonas putida S12, Extremophiles 13(2): 283-297.
- Wielen L.A.M. van der, Winde J.H. de & Lourens G. (2009), BIOT 163-B-Basic: Integrating bioprocess engineering and biological sciences, Abstracts of Papers of the American Chemical Society 238: .
- Sagt C.M.J., Haaft P.J. ten, Minneboo I.M., Hartog M.P., Damveld R.A., Laan J.M. van der, Akeroyd M., Wenzel T.J., Luesken F.A., Veenhuis M., Klei I. van der & Winde J.H. de (2009), Peroxicretion: a novel secretion pathway in the eukaryotic cell, BMC Biotechnology 9: 48.
- Daran-Lapujade P., Daran J.M., Maris A.J.A. van, Winde J.H. de & Pronk J.T. (2009), Chemostat-Based Micro-Array Analysis in Baker's Yeast, Advances in Microbial Physiology 54: 257-311.
- Wierckx N., Ruijssenaars H.J., Winde J.H. de, Schmid A. & Blank L.M. (2009), Metabolic flux analysis of a phenol producing mutant of Pseudomonas putida S12: Verification and complementation of hypotheses derived from transcriptomics, Journal of Biotechnology 143(2): 124-129.
- Knijnenburg T.A., Daran J.M.G., Broek M.A. van den, Daran-Lapujade P.A.S., Winde J.H. de, Pronk J.T., Reinders M.J.T. & Wessels L.F.A. (2009), Combinatorial effects of environmental parameters on transcriptional regulation in Saccharomyces cerevisiae: A quantitative analysis of a compendium of chemostat-based transcriptome data, BMC Genomics 10: 53.
- Wierckx N.J.P., Ballerstedt H., Bont J.A.M. de, Winde J.H. de, Ruijssenaars H.J. & Wery J. (2008), Transcriptome analysis of a phenol-producing Pseudomonas putida S12 construct: Genetic and physiological basis for improved production, Journal of Bacteriology 190(8): 2822-2830.
- Brink J. van den, Canelas A.B., Gulik W.M. van, Pronk J.T., Heijnen J.J., Winde J.H. de & Daran-Lapujade P. (2008), Dynamics of glycolytic regulation during adaptation of Saccharomyces cerevisiae to fermentative metabolism, Applied and Environmental Microbiology 74(18): 5710-5723.
- Meijnen J.-P., Winde J.H. de & Ruijssenaars H.J. (2008), Engineering Pseudomonas putida S12 for efficient utilization of D-xylose and L-arabinose, Applied and Environmental Microbiology 74(16): 5031-5037.
- Cipollina C., Brink J. van den, Daran-Lapujade P., Pronk J.T., Vai M. & Winde J.H. de (2008), Revisiting the role of yeast Sfp1 in ribosome biogenesis and cell size control: a chemostat study, Microbiology 154: 337-346.
- Cipollina C., Brink J. van den, Daran-Lapujade P., Pronk J.T., Porro D. & Winde J.H. de (2008), Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis, Microbiology 154(6): 1686-1699.
- Brink J. van den, Daran-Lapujade P., Pronk J.T. & Winde J.H. de (2008), New insights into the Saccharomyces cerevisiae fermentation switch: Dynamic transcriptional response to anaerobicity and glucose-excess, BMC Genomics 9: 100.
- Daran-Lapujade P., Rossell S., Gulik W.M. van, Luttik M.A.H., Groot M.J.L.de, Slijper M., Heck A.J.R., Daran J.-M., Winde J.H. de, Westerhoff H.V., Pronk J.T. & Bakker B.M. (2007), The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels, Proceedings of the National Academy of Sciences 104(40): 15753-15758.
- Knijnenburg T.A., Winde J.H. de, Daran J.M., Daran-Lapujade P., Pronk J.T., Reinders M.J.T. & Wessels L.F.A. (2007), Exploiting combinatorial cultivation conditions to infer transcriptional regulation, BMC Genomics 8: 25.
- Pel H.J., Winde J.H. de, Ram A.F.J., Hondel C.A.M.J.J. van den, Vondervoort P.J.I. van de & et al. (2007), Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88, Nature Biotechnology 25(2): 221-231.
- Boer V.M., Tai S.L., Vuralhan Z., Arifin Y., Walsh M.C., Piper M.D.W., Winde J.H., Pronk J.T. & Daran J.M. (2007), Transcriptional responses of Saccharomyces cerevisiae to preferred and nonpreferred nitrogen sources in glucose-limited chemostat cultures, FEMS Yeast Research 7(4): 604-620.
- Jansen M.L.A., Krook D.J.J., Graaf K. de, Dijken J.P., Pronk J.T. & Winde J.H. de (2006), Physiological characterization and fed-batch production of an extracellular maltase of Schizosaccharomyces pombe CBS 356, FEMS Yeast Research 6(6): 888-901.
- Hazelwood L.A., Tai S.L., Boer V.M., Winde J.H. de, Pronk J.T. & Daran J.M. (2006), A new physiological role for Pdr12p in Saccharomyces cerevisiae: export of aromatic and branched-chain organic acids produced in amino acid catabolism, FEMS Yeast Research 6(6): 937-945.
- Tai S.L., Boer V.M., Daran-Lapujade P., Walsh M.C., Winde J.H. de, Daran J.M. & Pronk J.T. (2005), Two-dimensional transcriptome analysis in chemostat cultures - Combinatorial effects of oxygen availability and macronutrient limitation in Saccharomyces cerevisiae, Journal of Biological Chemistry 280(1): 437-447.
- Aguilera J., Petit T., Winde J.H. de & Pronk J.T. (2005), Physiological and genome-wide transcriptional responses of Saccharomyees cerevisiae to high carbon dioxide concentrations, FEMS Yeast Research 5(6-7): 579-593.
- Boer V.M., Daran J.M., Almering M.J.H., Winde J.H. de & Pronk J.T. (2005), Contribution of the Saccharomyces cerevisiae transcriptional regulator Leu3p to physiology and gene expression in nitrogen- and carbon-limited chemostat cultures, FEMS Yeast Research 5(10): 885-897.
- Aguilera J., Dijken J.P. van, Winde J.H. de & Pronk J.T. (2005), Carbonic anhydrase (Nce103p): an essential biosynthetic enzyme for growth of Saccharomyces cerevisiae at atmospheric carbon dioxide pressure, Biochemical Journal 391(2): 311-316.
- Jansen M.L.A., Diderich J.A., Mashego M., Hassane A., Winde J.H. de, Daran-Lapujade P. & Pronk J.T. (2005), Prolonged selection in aerobic, glucose-limited chemostat cultures of Saccharomyces cerevisiae causes a partial loss of glycolytic capacity, Microbiology 151: 1657-1669.
- Jansen M.L.A., Daran-Lapujade P., Winde J.H. de, Piper M.D.W. & Pronk J.T. (2004), Prolonged maltose-limited cultivation of Saccharomyces cerevisiae selects for cells with improved maltose affinity and hypersensitivity, Applied and Environmental Microbiology 70(4): 1956-1963.
- Daran-Lapujade P., Jansen M.L.A., Daran J.M., Gulik W. van, Winde J.H. de & Pronk J.T. (2004), Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae - A chemostat culture study, Journal of Biological Chemistry 279(10): 9125-9138.
- Boer V.M., Winde J.H. de, Pronk J.T. & Piper M.D.W. (2003), The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur, Journal of Biological Chemistry 278(5): 3265-3274.
- Boer V., Winde J.H. de, Pronk J. & Piper M. (2003), Transcriptional responses of Saccharomyces cerevisiae to limitations of carbon, nitrogen, phosphorus or sulfur, Yeast 20: S333-S333.
- Jansen M.L.A., Winde J.H. de & Pronk J.T. (2002), Hxt-carrier-mediated glucose efflux upon exposure of Saccharomyces cerevisiae to excess maltose, Applied and Environmental Microbiology 68(9): 4259-4265.
- Rolland F., Wanke V., Cauwenberg L., Ma P., Boles E., Vanoni M., Winde J.H. de, Thevelein J.M. & Winderickx J. (2001), The role of hexose transport and phosphorylation in cAMP signalling in the yeast Saccharomyces cerevisiae, FEMS Yeast Research 1(1): 33-45.
- Hoof C. van, Janssens V., De Baere I., Stark M.J.R., Winde J.H. de, Winderickx J., Thevelein J.M., Merlevede W. & Goris J. (2001), The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations, Experimental Cell Research 264(2): 372-387.
- Bergsma J.C.T., Kasri N.N., Donaton M.C.V., Wever V. de, Tisi R., Winde J.H. de, Martegani E., Thevelein J.M. & Wera S. (2001), PtdIns(4,5)P-2 and phospholipase C-independent Ins(1,4,5)P-3 signals induced by a nitrogen source in nitrogen-starved yeast cells, Biochemical Journal 359(3): 517-523.
- Hoof C. van, Janssens V., Baere I. de, Winde J.H. de, Winderickx J., Dumortier F., Thevelein J.M., Merlevede W. & Goris J. (2000), The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle, Journal of Molecular Biology/JMB Online 302(1): 103-119.
- Rolland F., Winde J.H. de, Lemaire K., Boles E., Thevelein J.M. & Winderickx J. (2000), Glucose-induced cAMP signalling in yeast requires both a G-protein coupled receptor system for extracellular glucose detection and a separable hexose kinase-dependent sensing process, Molecular Microbiology 38(2): 348-358.
- Thevelein J.M., Cauwenberg L., Colombo S., Winde J.H. de, Donation M., Dumortier F., Kraakman L., Lemaire K., Ma P., Nauwelaers D., Rolland F., Teunissen A., Dijck P. van, Versele M., Wera S. & Winderickx J. (2000), Nutrient-induced signal transduction through the protein kinase A pathway and its role in the control of metabolism, stress resistance, and growth in yeast, Enzyme and Microbial Technology 26(9-10): 819-825.
- Kraakman L.S., Winderickx J., Thevelein J.M. & Winde J.H. (1999), Structure-function analysis of yeast hexokinase: structural requirements for triggering cAMP signalling and catabolite repression, Biochemical Journal 343(1): 159-168.
- Hohmann S., Winderickx J., Winde J.H. de, Valckx D. de, Cobbaert P., Luyten K., Meirsman C. de, Ramos J. & Thevelein J.M. (1999), Novel alleles of yeast hexokinase PII with distinct effects on catalytic activity and catabolite repression of SUC2, Microbiology 145: 703-714.
- Thevelein J.M. & Winde J.H. de (1999), Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae, Molecular Microbiology 33(5): 904-918.
- Versele M., Winde J.H. de & Thevelein J.M. (1999), A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2, The EMBO Journal 18(20): 5577-5591.
- Kraakman L., Lemaire K., Ma P.S., Teunissen A.W.R.H., Donaton M.C.V., Dijck P. van, Winderickx J., De Winde J.H. & Thevelein J.M. (1999), A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose, Molecular Microbiology 32(5): 1002-1012.
- Colombo S., Ma P.S., Cauwenberg L., Winderickx J., Crauwels M., Teunissen A., Nauwelaers D., Winde J.H. de, Gorwa M.F., Colavizza D. & Thevelein J.M. (1998), Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae, The EMBO Journal 17(12): 3326-3341.
- Ernandes J.R., De Meirsman C., Rolland F., Winderickx J., Winde J.H. de, Brandao R.L. & Thevelein J.M. (1998), During the initiation of fermentation overexpression of hexokinase PII in yeast transiently causes a similar deregulation of glycolysis as deletion of Tps1, Yeast 14(3): 255-269.
- Crauwels M., Winderickx J., Winde J.H. de & Thevelein J.M. (1997), Identification of genes with nutrient-controlled expression by PCR-mapping in the yeast Saccharomyces cerevisiae, Yeast 13(10): 973-984.
- Crauwels M., Donaton M.C.V., Pernambuco M.B., Winderickx J., Winde J.H. de & Thevelein J.M. (1997), The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway, Microbiology 143(8): 2627-2637.
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- Member, various Review Committees
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