Erik Danen
Professor of Cancer Drug Target Discovery / Dean Graduate School of Science
- Name
- Prof.dr. E.H.J. Danen
- Telephone
- +31 71 527 4486
- e.danen@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-0491-6345
Erik Danen (Ph.D) is Professor of Cancer Drug Target Discovery at the Division of Drug Discovery & Safety.
More information about Erik Danen
Group members
News
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3D-printed mini-tumours: a leap forward in improving cancer immunotherapy -
How metastatic tumours manipulate their environment -
'Working with PhD candidates gives me energy' -
Erik Danen new Dean of the Graduate School of Science -
How oxygen deprivation causes cancer cells to spread -
LACDR EMA Lunchtalk -
Erik Danen part of NWO Perspectief grant for organ-on-chip -
Probing the secret forces of pericytes -
Understanding metastasis: Science Groot grant for Erik Danen
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Science Groot funding for Leiden scientists -
Ensnaring tumours in their own web -
A rock star in a Petri dish -
From practical cookbook session to practical research session -
Erik Danen appointed as Professor of Cancer drug target discovery
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Dutch Cancer Society Fund grant for Leiden breast cancer research -
Tumours can use ‘remote control’ to attract blood vessels -
New zebrafish study to understand human cancer
After postdocs at NIH, Bethesda MD and NKI/AVL, Amsterdam NL, Erik Danen moved to Leiden University as tenure track Assistant Prof. and became tenured Associate Prof. in 2012, and full professor in 2018. He has managed biomedical research as PI, work package leader, or co-investigator in grants funded by the Dutch Scientific Organization (NWO), the Dutch Cancer Society (KWF), the European Union (FP7), the Netherlands Genomics Initiative, and Leiden University. His research centers on mechanisms underlying cancer metastasis and therapy resistance. It involves 2D and 3D tissue modeling and automated real time confocal microscopy. Much of the work takes place in the Leiden University Cell Observatory where high throughput RNAi / compound screening is applied. In collaboration with the Institute of Biology a pipeline for automated whole animal bioimaging of cancer growth and dissemination using zebrafish xenograft models has been established. In collaboration with the Institute of Physics in UL methodology has been developed to study the biophysical aspects of cell adhesion and cell migration.
Professor of Cancer Drug Target Discovery / Dean Graduate School of Science
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Toxicology
Dean Graduate School of Science
- Science
- Faculteit Algemeen
- Bergonzini C., Gregori A., Hagens T.M.S., Noord V.E. van der, Water B. van de, Zweemer A.J.M., Coban B., Capula M., Mantini G., Botto A., Finamore F., Garajova I., McDonnell L.A., Schmidt T., Giovannetti E. & Danen E.H.J. (2024), ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells, Journal of Experimental & Clinical Cancer Research 43: 4.
- Che P.P., Gregori A., Bergonzini C., Ali M., Mantini G., Schmidt. T., Finamore F., Fraga Rodrigues S.M., Frampton A.E., McDonnell L.A., Danen E.H.J., Slotman B.J., Sminia P. & Giovannetti E. (2024), Differential sensitivity to ionizing radiation in gemcitabine- and paclitaxel-resistant pancreatic cancer cells, International Journal of Radiation Oncology - Biology - Physics 118(5): 1328-1343.
- Coban B., Wang Z., Liao C., Beslmüller K., Timmermans M.A.M., Martens J.W.M., Hunscheid J.H.M., Slütter B.A., Zweemer A.J.M., Neubert E. & Danen E.H.J. (2024), GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment, iScience 27(5): 109738.
- Bergonzini C., Giovannetti E. & Danen E.H.J. (2024), Targeting ABC transporters in PDAC - past, present, or future?, OncoTarget 15: 403-406.
- Liao C., Engelberts P., Ioan-Facsinay A., Klip J.A., Schmidt T., Ruijtenbeek R. & Danen E.H.J. (2024), CD3-engaging bispecific antibodies trigger a paracrine regulated wave of T-cell recruitment for effective tumor killing, Communications Biology 7(1): 983.
- Kortleve D., Hammerl D., Brakel M. van, Wijers R., Roelofs D., Kroese K., Timmermans M.M., Liao C., Huang S., Trapman-Jansen A., Foekens R., Michaux J., Beijer M.T.A. de, Buschow S.I., Demmers J.A., Kok M., Danen E.H.J., Bassani-Sternberg M., Martens J.W.M., Abbott R.J.M. & Debets R. (2024), TCR-engineered T-cells directed against Ropporin-1 constitute a safe and effective treatment for triple-negative breast cancer, Cancer Discovery : 1-21.
- Gregori A., Bergonzini C., Capula M., Rodrigues Mercado R. de, Danen E.H.J., Giovannetti E. & Schmidt T. (2024), Altered mechanobiology of PDAC cells with acquired chemoresistance to gemcitabine and paclitaxel, Cancers 16(22): 3863.
- Feng C., Liu R., Brooks R., Wang X., Jespers W., Gorostiola Gonzalez M., Westen G.J. P. van, Danen E.H.J. & Heitman L.H. (2024), The effect of cancer-associated mutations on ligand binding and receptor function - a case for the 5-HT2C receptor, European Journal of Pharmacology 985: 177081.
- Dang H., Harryvan T.J., Liao C.Y., Danen E.H.J., Spalburg V.N.L.N., Kielbasa S.M., Mei H., Goeman J.J., Jonge-Muller E.S. de, Janson S.G.T., Reijden J.J. van der, Crobach S., Hardwick J.C.H., Boonstra J.J., Miranda N.F.C.C. de & Hawinkels L.J.A.C. (2023), Cancer-associated fibroblasts are key determinants of cancer cell invasion in the earliest stage of colorectal cancer, Cellular and Molecular Gastroenterology and Hepatology 16(1): 107-131.
- Bergonzini C., Gregori A., Hagen T.M.S., Noord V.E. van der, Water B. van der, Zweemer A.J.M., Capula M., Mantini G., Botta A., Finamore F., Garajova I., McDonnell L.A., Schmidt T, Giovannetti E. & Danen E.H.J. (2023), ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells. Journal of Experimental & Clinical Cancer Research. [working paper].
- Stel W. van der, Yang H., Le Dévédec S.E., Water B. van de, Beltman J.B. & Danen E.H.J. (2023), High-content high-throughput imaging reveals distinct connections between mitochondrial morphology and functionality for oxphos complex I, III, and V inhibitors, Cell Biology and Toxicology 39: 415-433.
- Wang Z., Coban B., Wu H., Chouaref J., Daxinger L., Paulsen M.T., Ljungman M., Smid M., Martens J.W.M. & Danen E.H.J. (2023), GRHL2-controlled gene expression networks in luminal breast cancer, Cell Communication and Signaling 21(1): 15.
- Gregori A., Bergonzini C., Capula M., Mantini G., Khojasteh-Leylakoohi F., Comandatore A., Khalili-Tanha G., Khooei A., Morelli L., Avan A., Danen E.H., Schmidt T. & Giovannetti E. (2023), Prognostic significance of integrin subunit alpha 2 (ITGA2) and role of mechanical cues in resistance to gemcitabine in pancreatic ductal adenocarcinoma (PDAC), Cancers 15(3): 628.
- Wang Z., Coban B., Liao C.Y., Chen Y.J., Liu Q. & Danen E.H.J. (2023), GRHL2 Regulation of growth/motility balance in luminal versus basal breast cancer, International Journal of Molecular Sciences 24(3): 2512.
- Liu Q., Liu N.S., Noord V.E. van der, Stel W. van der, Water B. van de, Danen E.H.J. & Le Dévédec S.E. (2023), Differential response of luminal and basal breast cancer cells to acute and chronic hypoxia, Breast Cancer Research and Treatment 198: 583-596.
- Stel W. van der, Yang H., Vrijenhoek N.G., Schimming J.P., Callegaro G., Carta G., Darici S., Delp J., Forsby A., White A., Le Dévédec S.E., Leist M., Jennings P., Beltman J.B., Water B. van de & Danen E.H.J. (2022), Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation, Archives of Toxicology 96: 259-285.
- Görte J., Danen E.H.J. & Cordes N. (2022), Therapy-naïve and radioresistant 3-dimensional pancreatic cancer cell cultures are effectively radiosensitized by β1 integrin targeting, International Journal of Radiation Oncology - Biology - Physics 112(2): 487-498.
- Balcioglu H.E., Harkes R., Danen E.H.J. & Schmidt T. (2022), Substrate rigidity modulates traction forces and stoichiometry of cell–matrix adhesions, The Journal of Chemical Physics 156(8): 1-13 (085101).
- Tong. C., Wondergem A.J., Brink M. van den, Kwakernaak M.C., Chen Y., Hendrix M.M.R.M., Voets I.K., Danen E.H.J., Le Dévédec S., Heinrich D.M. & Kieltyka R.E. (2022), Spatial and temporal modulation of cell instructive cues in a filamentous supramolecular biomaterial, ACS Applied Materials and Interfaces 14(15): 17042-17054.
- Bergonzini C., Kroese K., Zweemer J.M. & Danen E.H.J. (2022), Targeting integrins for cancer therapy - disappointments and opportunities, Frontiers in Cell and Developmental Biology 10: 863850.
- Liu Q., Stel W. van der, Noord V.E. van der, Leegwater H., Coban B., Elbertse K., Pruijs J.T.M., Béquignon O.J.M., Westen G.J.P. van, Dévédec S.E. le & Danen E.H.J. (2022), Hypoxia triggers TAZ phosphorylation in basal a triple negative breast cancer cells, International Journal of Molecular Sciences 23(17): 10119.
- Liu Q., Palmgren V.A.C., Danen E.H.J. & Le Dévédec S.E. (2022), Acute vs. chronic vs. intermittent hypoxia in breast cancer: a review on its application in in vitro research, Molecular Biology Reports 49(11): 10961-10973.
- Feng C.L., Wang X., Jespers W., Liu R., Zamarbide Losada S.D., Gorostiola Gonzalez M., Westen G.J.P. van, Danen E.H.J. & Heitman L.H. (2022), Cancer-associated mutations of the adenosine A2A receptor have diverse influences on ligand binding and receptor functions, Molecules 27(15): 4676.
- Dekker Y., Le Dévédec S.E., Danen E.H.J. & Liu Q. (2022), Crosstalk between hypoxia and extracellular matrix in the tumor microenvironment in breast cancer, Genes 13(9): 1585.
- Dang H., Harrijvan T.J., Liao C., Danen E.H.J., Miranda N.F. de, Hardwick J., Boonstra J. & Hawinkels L. (2022), Cancer-associated fibroblasts in T1 colorectal cancer promote matrix remodeling and tumor organoid expansion, Gastroenterology 162(7): S323.
- Stel W. van der, Carta G., Eakins J., Delp J., Suciu I., Forsby A., Cediel-Ulloa A., Attoff K., Troger F., Kamp H., Gardner I., Zdrazil B., Moné1 M.J., Ecker G.F., Pastor M., Gómez-Tamayo J.C., White A., Danen E.H.J., Leist M., Walker P., Jennings P., Hougaard Bennekou S. & Water B. van de (2021), New approach methods supporting read-across: two neurotoxicity AOP-based IATA case studies, ALTEX - Alternatives to Animal Experimentation 38(4): 615-635.
- Görte J., Beyreuther E., Danen E.H.J. & Cordes N. (2021), Correction: Comparative proton and photon irradiation combined with Pharmacological Inhibitors in 3D pancreatic cancer cultures, Cancers 13(13): 3364.
- Yang H., Stel W. van der, Lee R., Bauch C., Bevan S., Walker P., Water B. van de, Danen E.H.J. & Beltman J.B. (2021), Dynamic modeling of mitochondrial membrane potential upon exposure to mitochondrial inhibitors, Frontiers in Pharmacology 12: 679407.
- Stel W. van der Carta G. Eakins J. Darici S. Delp J. Forsby A. Bennekou S.H. Gardner I. Leist M. Danen E.H.J. Walker P. Water B. van de Jennings P. (2020), Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals, Archives of Toxicology 94(8): 2707-2729.
- Iendaltseva O. Orlova V.V. Mummery C.L. Danen E.H.J. Schmidt T. (2020), Fibronectin Patches as Anchoring Points for Force Sensing and Transmission in Human Induced Pluripotent Stem Cell-Derived Pericytes, Stem Cell Reports 14(6): 1107-1122.
- Schakenraad K. Ernst J. Pomp W. Danen E.H.J. Merks R.M.H. Schmidt T. Giomi L. (2020), Mechanical interplay between cell shape and actin cytoskeleton organization, Soft Matter 16(27): 6328-6343.
- Venneker S., Kruisselbrink A.B., Baranski Z., Palubeckaite I., Briaire-de Bruijn I.H., Oosting J., French P.J., Danen E.H.J. & Bovee J.V.M.G. (2020), Beyond the influence of IDH mutations: exploring epigenetic vulnerabilities in chondrosarcoma, Cancers 12(12): 3589.
- Gorte J., Beyreuther E., Danen E.H.J. & Cordes N. (2020), Comparative proton and photon irradiation combined with pharmacological inhibitors in 3D pancreatic cancer cultures, Cancers 12(11): 3216.
- Coban B., Bergonzini C., Zweemer J.M. & Danen E.H.J. (2020), Metastasis: crosstalk between tissue mechanics and tumour cell plasticity, British Journal of Cancer 124(1): 49-57.
- Booij T.H., Price L.S. & Danen E.H.J. (2019), 3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis, Slas Discovery 24(6): 615-627.
- Venneker S., Kruisselbrink A.B., Briaire-de Bruijn I.H., Jong Y. de, Wijnen A.J. van, Danen E.H.J. & Bovée J.V.M.G. (2019), Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status, Cancers 11(12): 1918.
- Jong Y. de, Bennani F., Oosterwijk J.G. van, Alberti G., Baranski Z., Wijers-Koster P., Venneker S., Briaire-de Bruij I.H., Akker B.E. van de, Baelde H., Cleton-Jansen A.M., Water B. van de, Danen E.H.J. & Bovée J.V.M.G. (2019), A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival, Journal of Bone Oncology 19: 100268.
- Schmidt T., Balcioglu H.E., Harkes R. & Danen E.H.J. (2018), Substrate Rigidity Modulates the Composition in Cell-Matrix Adhesions, Biophysical Journal 114(3): 19A-19A.
- Stel W. van der, Darici S., Water B. van de & Danen E. (2018), Unravelling essential key events in mitochondrial adverse outcome pathways, Toxicology Letters 295: S193-S194.
- Pomp W., Schakenraad K.K., Balcioglu H.E., Hoorn H. van der, Danen E.H.J, Merks R.M.H, Schmidt T. & Giomi L. (2018), Cytoskeletal anisotropy controls geometry and forces of adherent cells, Physical Review Letters 121(17): 178101.
- Zhang Y., Wester L., He J., Geiger T., Moerkens M., Siddappa R., Helmijr J.A., Timmermans M.M., Look M.P., Deurzen C.H.M. van, Martens J.W.M., Pont C.M., Graauw M. de, Danen E.H.J., Berns E.M.J.J., Jansen M.P.H.M., Meerman J.H.N. & Water B. van de (2018), IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer, Oncogene 37(14): 1869-1884.
- Hillger J.M., Roy B. le, Wang Z., Mulder-Krieger T., Boomsma D.I., Slagboom P.E., Danen E.H.J., IJzerman A.P. & Heitman L.H. (2017), Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype, Biochemical Pharmacology 130: 60-70.
- Burger G.A., Danen E.H.J. & Beltman J.B. (2017), Deciphering Epithelial-Mesenchymal Transition Regulatory Networks in Cancer through Computational Approaches, Frontiers in Oncology 7: 162.
- Leist M., Ghallab A., Graepel R., Marcahn R., Hassan R., Hougaard Bennekou S., Limonciel A., Vinken M., Schildknecht S., Waldmann T., Danen E.H.J., Ravenzway B. van, Kamp H., Gardner I., Godoy P., Bois F.Y., Braeuning A., Reif R., Oesch F., Drasdo D., Hoehme S., Schwarz M., Hartung T., Braunbeck T., Beltman J.B., Vrieling H., Sanza F., Forsby A., Gadaleta D., Fisher C., Kelm J., Fluri D., Ecker G., Zdrqazil B., terron A., Jennings P., Burg B. van der, Dooley S., Meijer A.H., Willighagen E., Martens M., Evelo C., Mombelli E., Taboureau O., Manovani A., Hardy B., Koch B., Escher S., Thriel C. van, Cadenas C., Kroese D., Water B. van de & Hengstler J.G. (2017), Adverse outcome pathways : opportunities, limitations and open questions, Archives of Toxicology 91(11): 3477-3505.
- Coppola S., Carnevale I., Danen E.H.J., Peters G.J., Schmidt T., Assaraf Y.G. & Giovannetti E. (2017), A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemoth 31: 43-51.
- Peterse E.F.P., Akker B.E.W.M. van den, Niessen B., Oosting J., Suijker J., De Jong Y., Danen E.H.J., Cleton-Jansen A.M. & Bovée J.V.M.G. (2017), NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma, Molecular Cancer Research 15(12): 1714-1721.
- Fokkelman M., Balcioglu H.E., Klip J.E., Yan K., Verbeek F.J., Danen E.H.J. & Water B. van de (2016), Cellular adhesome screen identifies critical modulators of focal adhesion dynamics, cellular traction forces and cell migration behaviour, Scientific Reports 6: 31707.
- Jong Y. de, Oosterwijk J.G. van, Kruisselbrink A.B., Briaire I.H., Agrogiannis G., Baranski Madrigal Z., Cleven A.H., Cleton A.M., Water B. van de, Danen E.H.J. & Bovée J.V.M.G. (2016), Targeting survivin as a potential new treatment for chondrosarcoma of bone, Oncogenesis 5: e222.
- Balcioglu H.E., Water B. van de & Danen E.H. (2016), Tumor-induced remote ECM network orientation steers angiogenesis, Scientific Reports 6: 22580.
- Pomp W., Schakenraad K.K., Hoorn H. van, Balciglu H.E., Danen E.H.J., Giomi L. & Schmidt T. (2016), Balance of Isotropic and Directed Forces Determines Cell Shape, Biophysical Journal 110(3): 305A-305A.
- Peterse E.F.P., Cleven A.H.G., Jong Y. de, Briaire-de Bruijn I., Fletcher J.A., Danen E.H.J., Cleton A.M. & Bov'ee J.V.M.G. (2016), No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone, BMC Cancer 16: 475.
- Heslop J.A., Hammond T.G., Santeramo I., Tort Piella A., Hopp I., Zhou J., Baty R., Graziano E.I., Proto Marco B., Caron A., Sköld P., Andrews P.W., Baxter M.A., Hay D.C., Hamdam J., Sharpe M.E., Patel S., Jones D.R., Reinhardt J., Danen E.H., Ben-David U., Stacey G., Björquist P., Piner J., Mills J., Rowe C., Pellegrini G., Sethu S., Antoine D.J., Cross M.J., Murray P., Williams D.P., Kitteringham N.R., Goldring C.E. & Park B.K. (2015), Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies, Stem cells translational medicine 4(4): 389-400.
- Balcioglu H.E., Hoorn H. van, Donato D.M., Schmidt T. & Danen E.H.J. (2015), The integrin expression profile modulates orientation and dynamics of force transmission at cell–matrix adhesions, Journal of Cell Science 128(7): 1316-1326.
- Baranski Z., Booij T.H., Kuijjer M.L., Jong Y. de, Cleton-Jansen A.M., Price L.S., Water B. van de, Bovée J.V., Hogendoorn P.C. & Danen E.H. (2015), MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation, Genes and Cancer 6(11-12): 503-12.
- Baranski Z., Booij T.H., Cleton-Jansen A.M., Price L.S., Water B. van de, Bovee J.V.M.G., Hogendoorn P.C.W. & Danen E.H.J. (2015), Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma, Journal of Pathology 236(3): 348-359.
- Ghotra V.P.S., He S., Horst G. van der, Nijhoff S., Bont H. de, Lekkerkerker A., Janssen R., Jenster G., Leenders G.J.L.H. van, Hoogland A., Marije M., Verhoef Esther I., Baranski Madrigal Z., Xiong J., Water B. van de, Pluijm G. van den, Snaar-Jagalska B.E. & Danen E.H.J. (2015), SYK is a candidate kinase target for the treatment of advanced prostate cancer, Cancer Research 75(1): 230-240.
- Suijker J., Oosting J., Koornneef A., Struys E.A., Salomons G.S., Schaap F.G., Waaijer C.J.F., Wijers-Koster P.M., Bruijn-de Briaire I.H., Haazen L., Riester S.M., Dudakovic A., Danen E., Cleton-Jansen A., Van Wijnen A.J. & Bovee J.V.M.G. (2015), Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines, OncoTarget 6(14): 12505-12519.
- Stechow L. von, Typas D., Puigvert J.C., Oort L., Siddappa R., Pines A., Vrieling H., Water B. van de, Mullenders L.H.F. & Danen E.H.J. (2015), The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest, Molecular and Cellular Biology 35(7): 1254-1268.
- Balcioglu H.E., Hoorn H. van, Donato D.M., Schmidt T. & Danen E.H.J. (2015), Integrins alpha5beta1 and alphvbeta3 differentially control orientation and dynamics of force transmission at cell matrix adhesions, Journal of Cell Science 128: 1316-1326.
- Jansen K.A., Donato D.M., Balcioglu H.E., Schmidt T., Danen E.H. & Koenderink G.H. (2015), A guide to mechanobiology: Where biology and physics meet, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853(11): 3043-3052.
- Baranski Madrigal Z., Booij T.H., Jong Y. de, Oosterwijk J. van, Cleton A.-M., Price L.S., Water B. van de, Bovee J.V.M.G., Hogendoorn P.C.W. & Danen E.H.J. (2015), Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in osteosarcoma cells, Cancer Research 75(15): 3780.
- Baranski Madrigal Z., Jong Y. de, Ilkova T.I., Peterse E.F.P., Cleton-Jansen A.M., Water B. van de, Hogendoorn P.C.W., Bovée J.V.M.G. & Danen E.H.J. (2015), Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin, OncoTarget 6(34): 36113-36125.
- Danen E.H.J. (2014), Ignoring matrix boundaries when the LKB1 master kinase is gone, Journal of Cell Biology 207(2): 167-169.
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- Wink S., Hiemstra S., Huppelschoten S., Danen E.H.J., Niemeijer M., Hendriks G., Vrieling H., Herpers B. & Water B. van de (2014), Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment, Chemical Research in Toxicology 27(3): 338-355.
- Truong H.H., Xiong J., Ghotra V.P.S., Nirmala E., Haazen L., Le Dévédec S.E., Balcioglu H.E., He S., Snaar-Jagalska B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H.J. (2014), beta(1) Integrin Inhibition Elicits a Prometastatic Switch Through the TGF beta-miR-200-ZEB Network in E-Cadherin-Positive Triple-Negative Breast Cancer, Science Signaling 7(312): ra15.
- Truong H.H., Xiong J., Ghotra V.P, Nirmala .E, Haazen L.C.J.M., Dévédec S.E. le, Balcioğlu H.E., He S., Snaar-Jagalska B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H. (2014), β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer, Science Signaling 7(312): ra15.
- Fredriksson L., Wink S., Herpers B.H.A., Benedetti G., Hadi M., Bont H.J.G.M. de, Groothuis G., Luijten M., Danen E.H.J., Graauw M. de, Meerman J.H.N. & Water B. van de (2014), Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity, Toxicological Sciences 140(1): 144-159.
- Stechow L. von der, Water B. van de & Danen E.H.J. (2013), Unraveling DNA damage response-signaling networks through systems approaches, Archives of Toxicology 87(9): 1635-1648.
- Stechow L. von der, Ruiz-Aracama A., Water B. van de, Peijnenburg A., Danen E.H.J. & Lommen A. (2013), Identification of cisplatin-regulated metabolic pathways in pluripotent stem cells, 8(10): e76476.
- Carreras Puigvert J., Stechow L. von der, Siddappa R., Pines A., Bahjat M., Haazen L.C., Olsen J.V., Vrieling H., Meerman J.H., Mullenders L.H., Water B. van de & Danen E.H.J. (2013), Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells, Science Signaling 6(259): ra5.
- Xiong J., Balcioglu H.E. & Danen E.H.J. (2013), Integrin signaling in control of tumor growth and progression, International Journal of Biochemistry and Cell Biology 45(5): 1012-1015.
- Ghotra V.P., Geldof A.A. & Danen E.H.J. (2013), Targeted radiosensitization in prostate cancer, Current Pharmaceutical Design 19(15): 2819-2828.
- Balcioglu H.E. & Danen E.H.J. (2013), Role of Integrin in Cellular Mechanotransduction, Biophysical Journal 104(2): 319A-319A.
- He S., Lamers G.E.M., Beenakker J.W.M., Cui C., Ghotra V.P., Danen E.H.J., Meijer A.H., Spaink H.P. & Snaar-Jagalska B.E. (2012), Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model, Journal of Pathology 227(4): 431-452.
- Damiano L., Le Devedec S.E., Di Stefano P., Repetto D., Lalai R.A., Truong H., Xiong J.L., Danen E.H., Yan K., Verbeek F.J., De Luca E., Attanasio F., Buccione R., Turco E., Water B. van de & Defilippi P. (2012), p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation, Oncogene 31(5): 624-633.
- Verissimo Carla S., Cheng Sou, Puigvert Jordi C., Qin Yu, Vroon Anne, Van Deutekom Judith, Price Leo S., Danen Erik H. J., Van de Water Bob, Fitzsimons Carlos P. & Vreugdenhil Erno (2012), Combining Doublecortin-Like Kinase Silencing and Vinca Alkaloids Results in a Synergistic Apoptotic Effect in Neuroblastoma Cells, Journal of Pharmacology and Experimental Therapeutics 342(1): 119-130.
- Truong H.H., Sonneville J. de, Ghotra V.P., Xiong J., Price L., Hogendoorn P.C., Spaink H.P., Water B. van de & Danen E.H. (2012), Automated microinjection of cell-polymer suspensions in 3D ECM scaffolds for high-throughput quantitative cancer invasion screens, Biomaterials 33(1): 181-188.
- Ghotra V.P., He S., Bont H.J.G.M. de, Ent W. van der, Spaink H.P., Water B. van de, Snaar-Jagalska B.E. & Danen E.H.J. (2012), Automated whole animal bio-imaging assay for human cancer dissemination, 7(2): e31281.
- Verissimo C.S., Cheng S., Puigvert J.C., Qin Y., Vroon A., Deutekom J. van, Price L.S., Danen E.H., Water B. van de, Fitzsimons C.P. & Vreugdenhil E. (2012), Combining doublecortin-like kinase silencing and vinca alkaloids results in a synergistic apoptotic effect in neuroblastoma cells, Journal of Pharmacology and Experimental Therapeutics 342(1): 119-130.
- Verissimo C.S., Molenaar J.J., Meerman J., Puigvert J.C., Pont C., Danen E.H.J., Water B. van de, Versteeg R., Fitzsimons C.P. & Vreugdenhil E. (2012), DOUBLECORTIN-LIKE KINASE: A POTENTIAL THERAPEUTIC TARGET FOR NEUROBLASTOMA, Neuro-Oncology 14: 91-91.
- Donato D. (2012), Insights into the Importance of mechanosensing through the Focal Adhesion Protein p130Cas. [other].
- Naber H.P.H., Wiercinska E., Pardali E., Laar T. van, Nirmala E., Sundqvist A., Dam H. van, Horst G. van der, Pluijm G. van der, Heckmann B., Danen E.H.J. & Dijke P. ten (2012), BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β3 expression, Cellular Oncology 35(1): 19-28.
- Fredriksson Lisa, Herpers Bram, Benedetti Giulia, Matadin Quraisha, Puigvert Jordi C., De Bont Hans, Dragovic Sanja, Vermeulen Nico P.E., Commandeur Jan N.M., Danen E.H.J., De Graauw Marjo & Van de Water Bob (2011), Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis, Hepatology 53(6): 2027-2041.
- Naber H.P., Wiercinska E., Pardali E., Van Laar T., Nirmala E., Sundqvist A., Van Dam H., Van der Horst G., Van der Pluijm G., Heckmann B., Danen E.H. & Ten Dijke P. (2011), BMP-7 inhibits TGF-beta-induced invasion of breast cancer cells through inhibition of integrin beta(3) expression, Cellular Oncology : .
- Pines A., Kelstrup C.D., Vrouwe M.G., Puigvert J.C., Typas D., Misovic B., De Groot A., Von Stechow L., Van de Water B., Danen E.H., Vrieling H., Mullenders L.H. & Olsen J.V. (2011), Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells, Molecular and Cellular Biology 31(24): 4964-4977.
- Le Dévédec S.E., Yan K., Bont H.J.G.M. de, Ghotra V.P., Truong H., Danen E.H., Verbeek F.J. & Water B. van de (2010), Systems microscopy approaches to understand cancer cell migration and metastasis, Cellular and Molecular Life Sciences 67(19): 3219-3240.
- Wang Z., Collighan R.J., Gross S.R., Danen E.H.J., Orend G., Telci D. & Griffin M. (2010), RGD-independent Cell Adhesion via a Tissue Transglutaminase-Fibronectin Matrix Promotes Fibronectin Fibril Deposition and Requires Syndecan-4/2 and alpha 5 beta 1 Integrin Co-signaling, Journal of Biological Chemistry 285(51): .
- Verissimo C.S., Molenaar J.J., Puigvert J.C., Lamers F., Van Kuik-Romeijn P., Danen E.H.J., Van de Water B., Versteeg R., Fitzsimons C.P. & Vreugdenhil E. (2010), Exploring a new therapy for neuroblastoma: silencing of doublecortin-like kinase using RNA-interference, EJC Supplements 8(5): 52-52.
- Huveneers S. & Danen E.H. (2010), The interaction of SRC kinase with beta3 integrin tails: a potential therapeutic target in thrombosis and cancer, ScientificWorldJournal 10: .
- Danen E.H.J., Van de Water B., Puigvert J.C., Von Stechow L., Siddappa R., Mullenders L. & Vrieling H. (2010), Mapping DNA damage response through RNAi screening and systems approach, Drug Metabolism Reviews 42: .
- Verissimo C.S., Molenaar J.J., Meerman J., Puigvert J.C., Lamers F., Van Kuik-Romeijn P., Danen E.H.J., Van de Water B., Versteeg R., Fitzsimons C.P. & Vreugdenhil E. (2010), Exploring a New Therapy for Neuroblastoma: Silencing of Doublecortin-Like Kinase Using Rna-Interference, Neuro-Oncology 12: .
- Huveneers Stephan & Danen Erik H.J. (2010), The Interaction of Src Kinase with beta 3 Integrin Tails: A Potential Therapeutic Target in Thrombosis and Cancer, The scientific World Journal 10: 1100-1105.
- Verissimo C.S., Molenaar J.J., Meerman J.H.N., Puigvert J.C., Lamers F., Koster J., Danen E.H., Water B. van de, Versteeg R., Fitzsimons C.P. & Vreugdenhil E.H.J. (2010), Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells, Endocrine-Related Cancer 17(2): 399-414.
- Wang Z., Collighan R.J., Gross S.R., Danen E.H.J., Orend G., Telci D. & Griffin M. (2010), RGD-independent Cell Adhesion via a Tissue Transglutaminase-Fibronectin Matrix Promotes Fibronectin Fibril Deposition and Requires Syndecan-4/2 and alpha 5 beta 1 Integrin Co-signaling, Journal of Biological Chemistry 285(51): 40212-40229.
- Puigvert J.C., Huveneers S., Fredriksson L., Veld M. op het, Water B. van de & Danen E.H.J. (2009), Cross-talk between integrins and oncogenes modulates chemosensitivity, Molecular Pharmacology 75(4): 947-55.
- Danen E.H. (2009), Integrin proteomes reveal a new guide for cell motility, Science Signaling 2(89): pe58.
- Huveneers S. & Danen E.H.J. (2009), Adhesion signaling - crosstalk between integrins, Src and Rho, Journal of Cell Science 122: 1059-1069.
- Truong H. & Danen E.H. (2009), Integrin switching modulates adhesion dynamics and cell migration, Cell Adhesion & Migration 3(2): 179-81.
- Ghotra V.P., Puigvert J.C. & Danen E.H. (2009), The cancer stem cell microenvironment and anti-cancer therapy, International Journal of Radiation Biology 85(11): 955-62.
- Miltenburg M.H. van, Lalai R.A., Bont H.J.G.M. de, Waaij E. van, Beggs H., Danen E.H.J. & Water B. van de (2009), Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility, The FASEB Journal 23(10): 3482-3493.
- Huveneers S., Arslan N., Water B. van de, Sonnenberg A. & Danen E.H.J. (2008), Integrins uncouple Src-induced morphological and oncogenic transformation, Journal of Biological Chemistry 283(19): 13243-13251.
- Huveneers S., Truong H., Faessler R., Sonnenberg A. & Danen E.H.J. (2008), Binding of soluble fibronectin to integrin α5ß1 - link to focal adhesion redistribution and contractile shape, Journal of Cell Science 121(15): 2452-2462.
- Huveneers Stephan, Truong Hoa & Danen Erik H.J. (2007), Integrins: Signaling, disease, and therapy, International Journal of Radiation Biology 83(11-12): 743-751.
- Huveneers S., Bout I. van de, Sonneveld P., Sancho A., Sonnenberg A. & Danen E.H.J. (2007), Integrin alphaVbeta 3 controls activity and oncogenic potential of primed c-Src, Cancer Research 67(6): 2693-2700.
- Huveneers S., Bout I. van den, Sonneveld P., Sancho A., Sonnenberg A. & Danen E.H.J. (2007), Integrin alpha(v)beta(3) controls activity and oncogenic potential of primed c-Src, Cancer Research 67(6): 2693-2700.
- Bout I. van de, Truong H.H., Huveneers S., Kuikman I., Danen E.H.J. & Sonnenberg A. (2007), The regulation of MacMARCKS expression by integrin beta 3, Experimental Cell Research 313: 1260-1269.
- Danen E.H.J., Rheenen J. van, Franken W., Huveneers S., Sonneveld P., Jalink K. & Sonnenberg A. (2005), Integrins control motile strategy through a Rho-cofilin pathway, Journal of Cell Biology 169(3): 515-526.
- Danen E.H.J., Rheenen J. van, Franken W., Huveneers S., Sonneveld P., Jalink K. & Sonnenberg A. (2005), Correction for: Integrins control motile strategy through a Rho-cofilin pathway (Vol. 169, No. 3, Pages 515-526, 2005), Journal of Cell Biology 170(3): 497.
- Danen E.H.J. (2005), Integrins: Regulators of tissue function and cancer progression, Current Pharmaceutical Design 11(7): 881-891.
- Danen E.H.J. & Sonnenberg A. (2003), Integrins in regulation of tissue development and function, Journal of Pathology 200(4): 471-480.
- Danen E.H.J. & Sonnenberg A. (2003), Integrins in regulation of tissue development and function (vol 200, pg 471, 2003), Journal of Pathology 201(4): 632-641.
- Danen E.H.J., Sonneveld P., Brakebusch C., Fassler R. & Sonnenberg A. (2002), The fibronectin-binding integrins alpha 5 beta 1 and alpha v beta 3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis, Journal of Cell Biology 159(6): 1071-1086.
- Danen E.H.J. & Yamada K.M. (2001), Fibronectin, integrins, and growth control, Journal of Cellular Physiology 189(1): 1-13.
- Danen E.H.J., Sonneveld P., Sonnenberg A. & Yamada K.M. (2000), Dual stimulation of Ras/Mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression, Journal of Cell Biology 151(7): 1413-1422.
- Gu J.G., Tamura M., Pankov R., Danen E.H.J., Takino T., Matsumoto K. & Yamada K.M. (1999), Shc and FAK differentially regulate cell motility and directionality modulated by PTEN, Journal of Cell Biology 146(2): 389-403.
- Danen E.H.J., Marcinkiewicz C., Cornelissen I.M.H.A., Kraats A.A. van, Pachter J.A., Ruiter D.J., Niewiarowski S. & Muijen G.N.P. van (1998), The disintegrin eristostatin interferes with integrin alpha 4 beta 1 function and with experimental metastasis of human melanoma cells, Experimental Cell Research 238(1): 188-196.
- Danen E.H.J., Lafrenie R.M., Miyamoto S. & Yamada K.M. (1998), Integrin signaling: Cytoskeletal complexes, MAP kinase activation, and regulation of gene expression, Cell Adhesion and Communication 6(2-3): 217-224.
- Marcinkiewicz C., Brando C., Danen E.H.J., Marcinkiewicz M.M. & Niewiarowski S. (1997), Disintegrin eristostatin inhibits lymphocyte infiltration of Langerhans islets in nod mice by inhibiting interaction of alpha 4 beta 1 integrin interaction with VCAM-1, The FASEB Journal 11(3): 602-602.
- Danen E.H.J., Berge P.J.M. ten, Muijen G.N.P. van, Jager M.J. & Ruiter D.J. (1996), Expression of CD44 and the pattern of CD44 alternative splicing in uveal melanoma, Melanoma Research 6(1): 31-35.
- Danen E.H.J., Jansen K.F.J., Klein C.E., Smit N.P.M., Ruiter D.J. & Muijen G.N.P. van (1996), Loss of adhesion to basement membrane components but not to keratinocytes in proliferating melanocytes, European Journal of Cell Biology 70(1): 69-75.
- Danen E.H.J., Kraats A.A. van, Cornelissen I.M.H.A., Ruiter D.J. & Muijen G.N.P. van (1996), Integrin beta 3 cDNA transfection into a highly metastatic alpha v beta 3-negative human melanoma cell line inhibits invasion and experimental metastasis, Biochemical and Biophysical Research Communications 226(1): 75-81.
- Danen E.H.J., Vries T.J. de, Morandini R., Ghanem G.G., Ruiter D.J. & Muijen G.N.P. van (1996), E-cadherin expression in human melanoma, Melanoma Research 6(2): 127-131.
- Muijen G.N.P. van, Kraats A.A. van, Ruiter D.J. & Danen E.H.J. (1996), Expression of the vitronectin receptor alpha v beta 3 inhibits invasion and metastasis of human melanoma cells, 107(3): 61-61.
- Muijen G.N.P., Danen E.H.J., Veerkamp J.H., Ruiter D.J., Lesley J. & Heuvel L.P.W.J. van den (1995), GLYCOCONJUGATE PROFILE AND CD44 EXPRESSION IN HUMAN-MELANOMA CELL-LINES WITH DIFFERENT METASTATIC CAPACITY, 61(2): 241-248.
- Bakker A.B.H., Marland G., Boer A.J. de, Huijbens R.J.F., Danen E.H.J., Adema G.J. & Figdor C.G. (1995), GENERATION OF ANTIMELANOMA CYTOTOXIC T-LYMPHOCYTES FROM HEALTHY DONORS AFTER PRESENTATION OF MELANOMA-ASSOCIATED ANTIGEN-DERIVED EPITOPES BY DENDRITIC CELLS IN-VITRO, Cancer Research 55(22): 5330-5334.
- Wesseling P., Danen E.H.J., Link M. & Ruiter D.J. (1995), MICROVASCULAR CELL-SUBSTRATUM INTEGRINS AND EXTRACELLULAR-MATRIX PROTEINS IN HUMAN GLIOBLASTOMA-MULTIFORME, Journal of Neuropathology and Experimental Neurology 54(3): 439-439.
- Danen E.H.J., Muijen G.N.P. van & Ruiter D.J. (1995), ROLE OF INTEGRINS AS SIGNAL-TRANSDUCING CELL-ADHESION MOLECULES IN HUMAN CUTANEOUS MELANOMA, Cancer Surveys 24: 43-65.
- Mantenhorst E., Danen E.H.J., Smith L., Snoek M., Poole I.C. Le, Muijen G.N.P. van, Pals S.T. & Ruiter D.J. (1995), EXPRESSION OF CD44 SPLICE VARIANTS IN HUMAN CUTANEOUS MELANOMA AND MELANOMA CELL-LINES IS RELATED TO TUMOR PROGRESSION AND METASTATIC POTENTIAL, 64(3): 182-188.
- De Waard-Siebinga I., Blom D.J.R., Griffioen M., Schrier P.I., Hoogendoorn E., Beverstock G., Danen E.H.J. & Jager M.J. (1995), Establishment and characterization of an uveal‐melanoma cell line, 62(2): 155-161.
- Danen E.H.J., Aota S., Kraats A.A. van, Yamada K.M., Ruiter D.J. & Muijen G.N.P. van (1995), Requirement for the Synergy Site for Cell Adhesion to Fibronectin Depends on the Activation State of Integrin alpha5beta1, Journal of Biological Chemistry 270(37): 21612-21618.
- Creygthton W.M., Waard-Siebinga I. de, Danen E.H.J., Luyten G.P.M., Muijen G.N.P. & Jager M.J. (1995), Cytokine-mediated modulation of integrin, ICAM-1 and CD44 expression on human uveal melanoma cells in vitro, Melanoma Research 5(4): 235-242.
- Danen E.H.J., Jansen K.F.J., Kraats A.A. van, Cornelissen I.M.H.A., Ruiter D.J. & Muijen G.N.P. van (1995), αv-Integrins in human melanoma: Gain of αvβ3 and loss of αvβ5 are related to tumor progression in situ but not to metastatic capacity of cell lines in nude mice, International Journal of Cancer 62(3): 365-365.
- Danen E.H.J., Bergen P.J.M. ten, Muijen G.N.P. van, Hof Grootenboer A.E. van 't, Brocker E.B. & Ruiter D.J. (1994), EMERGENCE OF ALPHA-5-BETA-1 FIBRONECTIN-RECEPTOR AND ALPHA-V-BETA-3 VITRONECTIN-RECEPTOR EXPRESSION IN MELANOCYTIC TUMOR PROGRESSION, Histopathology 24(3): 249-256.
- Danen E.H.J., Muijen G.N.P van, Wiel van Kemenade E. van de, Jansen K.F.J., Ruiter D.J. & Figdor C.G. (1993), REGULATION OF INTEGRIN-MEDIATED ADHESION TO LAMININ AND COLLAGEN IN HUMAN MELANOCYTES AND IN NONMETASTATIC AND HIGHLY METASTATIC HUMAN-MELANOMA CELLS, 54(2): 315-321.
- Berge P.J.M. ten, Danen E.H.J., Muijen G.N.P. van, Jager M.J. & Ruiter D.J. (1993), INTEGRIN EXPRESSION IN UVEAL MELANOMA DIFFERS FROM CUTANEOUS MELANOMA, Investigative Ophthalmology & Visual Science 34(13): 3635-3640.
- Danen E.H.J., Muijen G.N.P. van, Berge P.J.M. ten & Ruiter D.J. (1993), Integrins and melanoma progression, Recent Results in Cancer Research 128: 119-132.
- Martens G.J.M., Piosik P.A. & Danen E.H.J. (1992), EVOLUTIONARY CONSERVATION OF THE 14-3-3 PROTEIN, Biochemical and Biophysical Research Communications 184(3): 1456-1459.
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