Dmitri Filippov was born on November 21, 1966 in Moscow and studied chemistry at Moscow Institute of Fine Chemical Technology. After the graduation he learned the ABCs of synthetic bioorganic chemistry under the supervision of Dr. B.I. Mitsner. In 1992 he moved to Leiden and after a short period was appointed as a Ph.D. student in the group of Prof. J.H. van Boom. Upon completion of his Ph.D. thesis ‘Phosphoramidites in synthetic bioorganic chemistry’ he remained in the BIOSYN group working on a wide range of research topics for the most part involving synthesis of modified biopolymers. Over the years of continuous synthetic activities he also managed to contribute to the fields of natural product synthesis, fluorous chemistry and protein synthesis.

More information about Dmitri Filippov

Curriculum Vitae

Personal information

Nationality:   Dutch
Date of birth:   21 November 1966

Education

1998   PhD, Leiden Institute of Chemistry, Leiden University, The Netherlands, 24 November 1998. Thesis title: “Phosphoramidites in Synthetic Bioorganic Chemistry”
Advisors: Dr. G.A. van den Marel and Prof. J.H. van Boom
1991   MSc in Chemistry, Faculty of Chemistry, Moscow Lomonosov Institute of Fine Chemical Technology, Russia

Current and previous research positions

2020 – now    Associate Professor (tenured), Leiden Institute of Chemistry, Leiden University, The Netherlands
2009 – 2020   Tenured Assistant Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2004 – 2009   Postdoctoral researcher (Tenure track), Leiden Institute of Chemistry, Leiden University, The Netherlands (Prof. H. S. Overkleeft, Prof. G. A. van der Marel)
1997 – 2004   Postdoctoral researcher, Leiden Institute of Chemistry, Leiden University, The Netherlands (Prof. J. H. van Boom)

Grants, awards, recognitions since 2016

2020    NWO KLEIN-2 grant (kE 700), main applicant
2016    Leiden University, “Leiden Personalized Cancer Immunotherapy: Molecular Design of Mutanome-Based Vaccines for Individual Patients” (co-applicant, k€ 650)

Contribution to teaching and supervision

• Courses for MSc Chemistry at Leiden University: Synthetic Organic Chemistry, Reactivity in Organic Chemistry, Modern Organic Chemistry and Molecules of Life.
• Courses for Pre-University College at Leiden University

Co-supervision of 25 PhD students and 3 postdoctoral fellows since 2010.

Other current responsibilities since 2016

• Chair of a session on World Chemistry Congress The Hague, 20-25 August, 2023
• Organizer Focus Session Chemistry and Biology of Nicotinamide Adenine Dinucleotide at CHAINS 2018
• Poster jury member at "FEBS Advances Lectures Course PARP 2023" (Hvar, Croatia, 4-8 juni 2023)
• External member to PhD committee in Germany (2023)
• Reviewer for The Journal of Organic Chemistry, Chemistry: A European Journal, Journal of Medicinal Chemistry, Organic Letters, Bioorganic and Medicinal Chemistry Letters, Bioconjugate Chemistry and ChemBioChem.

Publication record including five recent representative publications

181 papers with >5000 citations, H-index 38 (Web of Science) 

Full publication record: Leiden University

• Voorneveld, J., Kloet, M. S., Kim, R.Q., Moutsiopoulou, A., Misra, M., Ðikić, I., van der Marel, G.A., Overkleeft, H. S., Filippov, D. V and van der Heden van Noort, G. J. (2022) Arginine ADP-    ribosylation: Chemical Synthesis of Post-Translationally Modified Ubiquitin Proteins, J. Am. Chem. Soc. 144, 20582-20589. DOI: 10.1021/jacs.2c06249
• Liu, Q., Knobloch, G., Voorneveld, J., Meeuwenoord, N. J., Overkleeft, H. S., van der Marel, G. A., Ladurner, A. G., and Filippov, D. V. (2021) Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1, Chem. Sci. DOI: 10.1039/d1sc02340c
• Rack, J.G.M., Liu Q., Zorzini V., Voorneveld J., Ariza A., Honarmand Ebrahimi K., Reber J.M., Krassnig S.C., Ahel D., van der Marel G.A., Mangerich A., McCullagh J.S.O., Filippov D.V., Ahel I.     (2021) Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal. Nat Commun 12 4581. DOI: 10.1038/s41467-021-24723-3
• Engelsma, S. B., Meeuwenoord, N. J., Overkleeft, H. S., van der Marel, G. A., and Filippov, D. V. (2017) Combined phosphoramidite-phosphodiester reagents for the synthesis of methylene     bisphosphonates, Angew Chem Int Ed 56, 2955-2959. DOI: 10.1002/anie.201611878
• Kistemaker, H. A. V., Nardozza, A. P., Overkleeft, H. S., van der Marel, G. A., Ladurner, A. G., and Filippov, D. V. (2016) Synthesis and macrodomain binding of Mono-ADP-ribosylated peptides,     Angew Chem Int Ed 55, 10634-10638. DOI: 10.1002/anie.201604058

Presentations including five presentations at international conferences since 2016

~30 invited presentations at universities, companies and institutes

• 2024, April 3-6 th,The PARP Family and ADP-ribosylation, Cold Spring Harbor, NY, USA
• 2023, November 6-11th, FEBS Advanced Course Cellular Stress and ADP-ribosylation, Naples, Italy
• 2022, June 10th, Chemical Immunology Conference, Leiden, NL
• 2021, November 8-11th, FEBS Advanced Course Cellular Stress and ADP-ribosylation, Naples, Italy
• 2017, November 8th GLICOVAX Training Event III, Leiden, NL
• 2017, July 13th, FASEB SRC: “NAD+ Methabolism and Signaling”, New Orleans, USA
• 2016, July 24-29, Chemical Biology-2016, Novosibirsk, Russia

Publications