Dmitri Filippov
Associate professor
- Name
- Dr. D.V. Filippov
- Telephone
- +31 71 527 3571
- filippov@chem.leidenuniv.nl
- ORCID iD
- 0000-0002-6978-7425
Dmitri Filippov was born on November 21, 1966 in Moscow and studied chemistry at Moscow Institute of Fine Chemical Technology. After the graduation he learned the ABCs of synthetic bioorganic chemistry under the supervision of Dr. B.I. Mitsner. In 1992 he moved to Leiden and after a short period was appointed as a Ph.D. student in the group of Prof. J.H. van Boom. Upon completion of his Ph.D. thesis ‘Phosphoramidites in synthetic bioorganic chemistry’ he remained in the BIOSYN group working on a wide range of research topics for the most part involving synthesis of modified biopolymers. Over the years of continuous synthetic activities he also managed to contribute to the fields of natural product synthesis, fluorous chemistry and protein synthesis.
More information about Dmitri Filippov
PhD candidates
Teaching
Former PhD Candidates
Curriculum Vitae
Personal information
Nationality: Dutch
Date of birth: 21 November 1966
Education
1998 PhD, Leiden Institute of Chemistry, Leiden University, The Netherlands, 24 November 1998. Thesis title: “Phosphoramidites in Synthetic Bioorganic Chemistry”
Advisors: Dr. G.A. van den Marel and Prof. J.H. van Boom
1991 MSc in Chemistry, Faculty of Chemistry, Moscow Lomonosov Institute of Fine Chemical Technology, Russia
Current and previous research positions
2020 – now Associate Professor (tenured), Leiden Institute of Chemistry, Leiden University, The Netherlands
2009 – 2020 Tenured Assistant Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2004 – 2009 Postdoctoral researcher (Tenure track), Leiden Institute of Chemistry, Leiden University, The Netherlands (Prof. H. S. Overkleeft, Prof. G. A. van der Marel)
1997 – 2004 Postdoctoral researcher, Leiden Institute of Chemistry, Leiden University, The Netherlands (Prof. J. H. van Boom)
Grants, awards, recognitions since 2016
2020 NWO KLEIN-2 grant (kE 700), main applicant
2016 Leiden University, “Leiden Personalized Cancer Immunotherapy: Molecular Design of Mutanome-Based Vaccines for Individual Patients” (co-applicant, k€ 650)
Contribution to teaching and supervision
- Courses for MSc Chemistry at Leiden University: Synthetic Organic Chemistry, Reactivity in Organic Chemistry, Modern Organic Chemistry and Molecules of Life.
- Courses for Pre-University College at Leiden University
Co-supervision of 25 PhD students and 3 postdoctoral fellows since 2010.
Other current responsibilities since 2016
- Chair of a session on World Chemistry Congress The Hague, 20-25 August, 2023
- Organizer Focus Session Chemistry and Biology of Nicotinamide Adenine Dinucleotide at CHAINS 2018
- Poster jury member at "FEBS Advances Lectures Course PARP 2023" (Hvar, Croatia, 4-8 juni 2023)
- External member to PhD committee in Germany (2023)
- Reviewer for The Journal of Organic Chemistry, Chemistry: A European Journal, Journal of Medicinal Chemistry, Organic Letters, Bioorganic and Medicinal Chemistry Letters, Bioconjugate Chemistry and ChemBioChem.
Publication record including five recent representative publications
181 papers with >5000 citations, H-index 38 (Web of Science)
Full publication record: Leiden University
- Voorneveld, J., Kloet, M. S., Kim, R.Q., Moutsiopoulou, A., Misra, M., Ðikić, I., van der Marel, G.A., Overkleeft, H. S., Filippov, D. V and van der Heden van Noort, G. J. (2022) Arginine ADP- ribosylation: Chemical Synthesis of Post-Translationally Modified Ubiquitin Proteins, J. Am. Chem. Soc. 144, 20582-20589. DOI: 10.1021/jacs.2c06249
- Liu, Q., Knobloch, G., Voorneveld, J., Meeuwenoord, N. J., Overkleeft, H. S., van der Marel, G. A., Ladurner, A. G., and Filippov, D. V. (2021) Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1, Chem. Sci. DOI: 10.1039/d1sc02340c
- Rack, J.G.M., Liu Q., Zorzini V., Voorneveld J., Ariza A., Honarmand Ebrahimi K., Reber J.M., Krassnig S.C., Ahel D., van der Marel G.A., Mangerich A., McCullagh J.S.O., Filippov D.V., Ahel I. (2021) Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal. Nat Commun 12 4581. DOI: 10.1038/s41467-021-24723-3
- Engelsma, S. B., Meeuwenoord, N. J., Overkleeft, H. S., van der Marel, G. A., and Filippov, D. V. (2017) Combined phosphoramidite-phosphodiester reagents for the synthesis of methylene bisphosphonates, Angew Chem Int Ed 56, 2955-2959. DOI: 10.1002/anie.201611878
- Kistemaker, H. A. V., Nardozza, A. P., Overkleeft, H. S., van der Marel, G. A., Ladurner, A. G., and Filippov, D. V. (2016) Synthesis and macrodomain binding of Mono-ADP-ribosylated peptides, Angew Chem Int Ed 55, 10634-10638. DOI: 10.1002/anie.201604058
Presentations including five presentations at international conferences since 2016
~30 invited presentations at universities, companies and institutes
- 2024, April 3-6 th,The PARP Family and ADP-ribosylation, Cold Spring Harbor, NY, USA
- 2023, November 6-11th, FEBS Advanced Course Cellular Stress and ADP-ribosylation, Naples, Italy
- 2022, June 10th, Chemical Immunology Conference, Leiden, NL
- 2021, November 8-11th, FEBS Advanced Course Cellular Stress and ADP-ribosylation, Naples, Italy
- 2017, November 8th GLICOVAX Training Event III, Leiden, NL
- 2017, July 13th, FASEB SRC: “NAD+ Methabolism and Signaling”, New Orleans, USA
- 2016, July 24-29, Chemical Biology-2016, Novosibirsk, Russia
Associate professor
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Bio-organic Synthesis
- Minnee H., Rack J.G.M., Marel G.A. van der, Overkleeft H.S., Codée J.D.C., Ahel I. & Filippov D.V. (2024), Solid-phase synthesis and biological evaluation of peptides ADP-Ribosylated at histidine, Angewandte Chemie (International Edition) 63(4): e202313317.
- Guo J., Balić P., Borodkin V.S., Filippov D.V. & Codee J.D.C. (2024), Synthesis of unsymmetrical difluoromethylene bisphosphonates, Organic Letters 26(3): 739-744.
- Doelman W., Ligthart N.A.M., Plassche M.A.T. van de, Geus M.A.R. de, Reinalda L., Isendoorn M.M.E., Filippov D.V. & Kasteren S.I. van (2024), Synthesis of peptides containing a combination of free and 2-trans-cyclooctene carbamate protected lysine residues, ChemBioChem 25(4): e202300786.
- Remmerswaal W.A., Jong T. de, Vrande K.N.A. van de, Louwersheimer R., Verwaal T., Filippov D.V., Codee J.D.C. & Hansen T. (2024), Backside versus frontside SN2 reactions of alkyl triflates and alcohols, Chemistry: a European Journal 30(25): e202400590.
- Rijpkema K.J., Schuller M., Van der veer M.S., Rieken S., Chang D.L.R., Balic P., Todorov A., Minnee H., Wijngaarden S., Matos I.A., Hoch N.C., Codee J.D.C., Ahel I. & Filippov D.V. (2024), Synthesis of structural ADP-ribose analogues as inhibitors for SARS-CoV-2 macrodomain 1, Organic Letters 26(27): 5700-5704.
- Minnee H., Chung H.W., Rack J.G.M., Marel G.A. van der, Overkleeft H.S., Codee J.D.C., Ahel I. & Filippov D.V. (2023), Four of a kind: a complete collection of ADP-ribosylated histidine isosteres using Cu(I)- and Ru(II)-catalyzed click chemistry, Journal of Organic Chemistry (JOC) 88(15): 10801-10809.
- Madern J.M., Voorneveld J., Rack J.G.M., Kistemaker H.A.V., Ahel I., Marel G.A. van der, Codee J.D.C. & Filippov D.V. (2023), 4-thioribose analogues of adenosine diphosphate ribose (ADPr) peptides, Organic Letters 25(27): 4980-4984.
- Tashiro K., Wijngaarden S., Mohapatra J., Rack J.G.M., Ahel I., Filippov D.V. & Liszczak G. (2023), Chemoenzymatic and synthetic approaches to investigate aspartate- and glutamate-ADP-ribosylation, Journal of the American Chemical Society 145(25): 14000-14009.
- Vrande K.N.A. van de, Filippov D.V. & Codee J.D.C. (2023), Formation of glycosyl trichloroacetamides from trichloroacetimidate donors occurs through an intermolecular aglycon transfer reaction, Organic Letters 25(33): 6128–6132.
- Đukić N., Strømland Ø., Elsborg J.D., Munnur D., Zhu K., Schuller M., Chatrin C., Kar P., Duma L., Suyari O., Rack J.G.M., Baretić D., Crudgington D.R.K., Groslambert J., Fowler G., Wijngaarden S., Prokhorova E., Rehwinkel J., Schüler H., Filippov D.V., Sanyal S., Ahel D., Nielsen M.L., Smith R. & Ahel I. (2023), PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities, Science Advances 9(37): eadi2687.
- Wijngaarden S., Yang C., Vela-Rodríguez C., Lehtiö L., Overkleeft H.S., Paschal B.M. & Filippov D.V. (2023), Synthetic dual cysteine-ADP ribosylated peptides from the androgen receptor are recognized by the DTX3L/PARP9 complex, ACS Chemical Biology 18(11): 2377-2384.
- Luscher B., Ahel I., Altmeyer M., Ashworth A., Bai P.T., Chang P., Cohen M., Corda D., Dantzer F., Daugherty M.D., Dawson T.M., Dawson V.L., Deindl S., Fehr A.R., Feijs K.L.H., Filippov D.V., Gagne J.P., Grimaldi G., Guettler S., Hoch N.C., Hottiger M.O., Korn P., Kraus W.L., Ladurner A., Lehtio L., Leung A.K.L., Lord C.J., Mangerich A., Matic I., Matthews J., Moldovan G.L., Moss J., Natoli G., Nielsen M.L., Niepel M., Nolte F., Pascal J., Paschal B.M., Pawlowski K., Poirier G.G., Smith S., Timinszky G., Wang Z.Q., Yelamos J., Yu X.C., Zaja R. & Ziegler M. (2022), ADP-ribosyltransferases, an update on function and nomenclature, FEBS Journal 289(23): 7399-7410.
- Ham A. van der, Liu X., Calvani D., Melcrová A., Kozdra M., Buda F., Overkleeft H.S., Roos W.H., Filippov D.V. & Schneider G.F. (2022), Freestanding non-covalent thin films of the propeller-shaped polycyclic aromatic hydrocarbon decacyclene, Nature Communications 13(1): 1920.
- Tondini E., Reintjens N.R.M., Castello G., Arakelian T., Isendoorn M.M.E., Camps M., Vree J., Marel G.A. van der, Filippov D.V., Codee J.D.C. & Ossendorp F. (2022), Lipid A analog CRX-527 conjugated to synthetic peptides enhances vaccination efficacy and tumor control, npj Vaccines 7: 64.
- Minnee H., Rack J.G.M., Marel G.A. van der, Overkleeft H.S., Codee J.D.C., Ahel I. & Filippov D.V. (2022), Mimetics of ADP-ribosylated histidine through copper(I)-catalyzed click chemistry, Organic Letters 24(21): 3776-3780.
- Remmerswaal W.A., Houthuijs K.J., Ven R. van de, Elferink H., Hansen T., Berden G., Overkleeft H.S., Marel G.A. van der, Rutjes F., Filippov D.V., Boltje T.J., Martens J., Oomens J. & Codee J.D.C. (2022), Stabilization of glucosyl dioxolenium Ions by "dual participation" of the 2,2-dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) protection group for 1,2-cis-glucosylation, Journal of Organic Chemistry (JOC) 87(14): 9139-9147.
- Peterse E., Meeuwenoord N.J., Elst H. van den, Marel G.A. van der, Overkleeft H.S. & Filippov D.V. (2022), Solid-phase synthesis of macrocyclic peptides via side-chain anchoring of the ornithine delta-amine, European Journal of Organic Chemistry 2022(11): e202101341.
- Voorneveld J., Kloet M.S., Wijngaarden S., Kim R.Q., Moutsiopoulou A., Verdegaal M., Misra M., Dikic I., Marel G.A. van der, Overkleeft H.S., Filippov D.V. & Noort G.J.V. van (2022), Arginine ADP-ribosylation: chemical synthesis of post-translationally modified ubiquitin proteins, Journal of the American Chemical Society 144(45): 20582-20589.
- Speetjens F.M., Welters M.J.P., Slingerland M., Poelgeest M.I.E. van, Steenwijk P.J.D. van, Roozen I., Boekestijn S., Loof N.M., Zom G.G., Valentijn A.R.P.M., Krebber W.J., Meeuwenoord N.J., Janssen C.A.H., Melief C.J.M., Marel G.A. van der, Filippov D.V., Burg S.H. van der, Gelderblom H. & Ossendorp F. (2022), Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions, Journal for ImmunoTherapy of Cancer 10(10): e005016.
- Weixler L., Ikenga N.J., Voorneveld J., Aydin G., Bolte T.M.H.R., Momoh J., Bütepage M., Golzmann A., Lüscher B., Filippov D.V., Zaja R. & Feijs K.L.H. (2022), Protein and RNA ADP-ribosylation detection is influenced by sample preparation and reagents used, Life Science Alliance 6(1): e202201455.
- Ende T.C. van den, Heuts J.M.M., Gential G.P.P., Visser M., Graaff M.J. van de, Ho N.I., Jiskoot W., Valentijn A.R.P.M., Meeuwenoord N.J., Overkleeft H.S., Codée J.D.C., Burg S.H. van der, Verdegaal E.M.E., Marel G.A. van der, Ossendorp F. & Filippov D.V. (2021), Simplified monopalmitoyl toll-like receptor 2 ligand mini-UPam for self-adjuvanting neoantigen-based synthetic cancer vaccines, ChemBioChem 22(7): 1215-1222.
- Kim R.Q., Misra M., Gonzalez A., Tomašković I., Shin D., Schindelin H., Filippov D.V., Ovaa H., Đikić I. & Heden- van Noort G.J. van der (2021), Development of ADPribosyl ubiquitin analogues to study enzymes involved in Legionella infection, Chemistry: a European Journal 27(7): 2506-2512.
- Hansen T., Vermeeren P., Yoshisada R., Filippov D.V., Marel G.A. van der, Codee J.D.C. & Hamlin T.A. (2021), How Lewis acids catalyze ring-openings of cyclohexene oxide, Journal of Organic Chemistry (JOC) 86(4): 3565-3573.
- Ali S., Hendriks A., Dalen R. van, Bruyning T., Meeuwenoord N., Overkleeft H.S., Filippov D.V., Marel G.A. van der Sorge N.M. van & Codee J.D.C. (2021), (Automated) synthesis of well-defined staphylococcus aureus wall teichoic acid fragments, Chemistry: a European Journal 27(40): 10461-10469.
- Voorneveld J., Rack J.G.M., Gijlswijk L.M. van, Meeuwenoord N.J., Liu Q., Overkleeft H.S., Marel G.A. van der, Ahel I. & Filippov D.V. (2021), Molecular tools for the study of ADP-Ribosylation: a unified and versatile method to synthesise native mono-ADP-ribosylated peptides, Chemistry: a European Journal 27(41): 10621-10627.
- Ham A. van der, Overkleeft H.S., Filippov D.V. & Schneider G.F. (2021), A three-step synthesis of 4H-cyclopenta[def]phenanthrene from pyrene, European Journal of Organic Chemistry 2021(13): 2013-2017.
- Liu Q., Knobloch G., Voorneveld J., Meeuwenoord N.J., Overkleeft H.S., Marel G.A. van der, Ladurner A.G. & Filippov D.V. (2021), Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1, Chemical Science 12(37): 12468-12475.
- Reijneveld J.F., Marino L., Cao T.P., Cheng T.Y., Dam D., Shahine A., Witte M.D., Filippov D.V., Suliman S., Marel G.A. van der, Moody D.B., Minnaard A.J., Rossjohn J., Codee J.D.C. & Rhijn I. van (2021), Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells, Journal of Biological Chemistry 297(4): 101197.
- Rack J.G.M., Liu Q., Zorzini V., Voorneveld J., Ariza A., Ebrahimi K.H., Reber J.M., Krassnig S.C., Ahel D., Marel G.A. van der, Mangerich A., McCullagh J.S.O., Filippov D.V. & Ahel I. (2021), Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal, Nature Communications 12: 4581.
- Kliza K.W., Liu Q., Roosenboom L.W.M., Jansen P.W.T.C., Filippov D.V. & Vermeulen M. (2021), Reading ADP-ribosylation signaling using chemical biology and interaction proteomics, Molecular Cell 81(21): 4552-4567.
- Speetjens F.M., Welters M.J.P., Slingerland M., Steenwijk P.D. van, Roozen I.C.F.M., Boekestijn S., Loof N., Zom G.G., Valentijn R., Krebber W.J., Melief C.J.M., Filippov D.V., Gelderblom H., Burg S.H. van & Ossendorp F.A. (2021), Phase I trial to determine safety and immunogenicity of amplivant, a synthetic toll-like receptor 2 ligand, conjugated to two HPV16 E6 synthetic long peptides, Journal of Clinical Oncology 39(15): 2614-2614.
- Overkleeft H.S., Xin B.T., Espinal C.G.A., Bruin G. de, Filippov D.V., Marel G.A. van der & Florea B.I. (2020), Two-step bioorthogonal activity-based protein profiling of individual human proteasome catalytic sites, ChemBioChem 21(1-2): 248-255.
- Hogervorst T.P., Li R.J.E., Marino L., Bruijns S.C.M., Meeuwenoord N.J., Filippov D.V., Overkleeft H.S., Marel G.A. van der, Vliet S.J. van, Kooyk Y. van & Codée J.D.C. (2020), C-Mannosyl Lysine for Solid Phase Assembly of Mannosylated Peptide Conjugate Cancer Vaccines, ACS Chemical Biology 15(3): 728-739.
- Geus M.A.R. de, Maurits E., Sarris A.J.C., Hansen T., Kloet M.S., Kamphorst K., Hoeve W. ten, Robillard M.S., Pannwitz A., Bonnet S.A., Codée J.D.C., Filippov D.V., Overkleeft H.S. & Kasteren S.I. van (2020), Fluorogenic Bifunctional Trans-cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics, Chemistry: a European Journal 26(44): 9900-9904.
- Mechelen J. van, Voorneveld J., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codée J.D.C. (2020), Synthesis of orthogonally protected and functionalized bacillosamines, Organic and Biomolecular Chemistry 18(15): 2834-2837.
- Hansen T. Elferink H. Hengst J.M.A. van Houthuijs K.J. Remmerswaal W.A. Kromm A. Berden G. Vorm S. van der Rijs A.M. Overkleeft H.S. Filippov D.V. Rutjes F.P.J.T. Marel G.A. van der Martens J. Oomens J. Codée J.D.C. Boltje T.J. (2020), Characterization of glycosyl dioxolenium ions and their role in glycosylation reactions, Nature Communications 11(1): 2664.
- Madern J.M. Kim R.Q. Misra M. Dikic I. Zhang Y. Ovaa H. Codée J.D.C. Filippov D.V. Heden van Noort G.J. van der (2020), Synthesis of Stable NAD+ Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC , ChemBioChem 21(20): 2903-2907.
- Voorneveld J., Florea B.I., Bakkum T., Mendowicz R.J., Veer M.S. van der, Gagestein B., Kasteren S.I. van, Stelt M. van der, Overkleeft H.S. & Filippov D.V. (2020), Olaparib-Based Photoaffinity Probes for PARP-1 Detection in Living Cells, ChemBioChem 21: 1-5.
- Enotarpi J.Tontini M. Balocchi C. Es D. van der Auberger L. Balducci E. Carboni F. Proietti D. Casini D. Filippov D.V. Overkleeft H.S. Marel G.A. van der Colombo C. Romano M.R. Berti F. Costantino P. Codeé J.D.C. Lay L. Adamo R. (2020), A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A, Nature Communications 11: 4434.
- Reintjens N.R.M., Tondini E., Vis C., McGlinn T., Meeuwenoord N.J., Hogervorst T.P., Overkleeft H.S., Filippov D.V., Marel G.A. van der, Ossendorp F.A. & Codée J.D.C. (2020), Multivalent, stabilized mannose-6-phosphates for the targeted delivery of toll-like receptor ligands and peptide antigens, ChemBioChem 22(2): 434-440.
- Hansen T., Ofman T.P., Vlaming J.G.C., Gagarinov I.A., Beek J. van, Goté T.A., Tichem J.M., Ruijgrok G., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codée J.D.C. (2020), Reactivity-stereoselectivity mapping for the assembly of Mycobacterium marinum lipooligosaccharides, Angewandte Chemie (International Edition) 60(2): 937-945.
- Reintjens N.R.M., Koemans T.S., Zilverschoon N., Castelli R., Cordfunke R.A., Drijfhout J.W., Meeuwenoord N.J., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codée J.D.C. (2020), Synthesis of C-Glycosyl Amino Acid Building Blocks Suitable for the Solid-Phase Synthesis of Multivalent Glycopeptide Mimics, European Journal of Organic Chemistry 2020(32): 5126-5139.
- Li R.J.E., Hogervorst T.P., Achilli S., Bruijns S.C.M., Spiekstra S., Vives C., Thepaut M., Filippov D.V., Marel G.A. van der, Vliet S.J. van, Fieschi F., Codee J.D.C. & Kooyk Y. van (2020), Targeting of the C-Type Lectin Receptor Langerin Using Bifunctional Mannosylated Antigens, Frontiers in Cell and Developmental Biology 8: 556.
- Enotarpi J., Tontini M., Balocchi C., Es D. van der, Auberger L.C., Balducci E., Carboni F., Proietti D., Casini D., Filippov D.V., Overkleeft H.S., Marel G.A. van der, Colombo C., Romano M.R., Berti F., Costantino P., Codeé J.D.C., Lay L. & Adamo R. (2020), Publisher correction: a stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A, Nature Communications 11(1): 6155.
- Reintjens N.R.M., Tondini E., Jong A.R. de, Meeuwenoord N.J., Chiodo F., Peterse E., Overkleeft H.S., Filippov D.V., Marel G.A. van der, Ossendorp F.A. & Codée J.D.C. (2020), Self-adjuvanting cancer vaccines from conjugation-ready lipid A analogues and synthetic long peptides, Journal of Medicinal Chemistry 63(20): 11691-11706.
- Madern J.M., Hansen T., Rijssel E.R. van, Kistemaker H.A.V., Vorm S. van der, Overkleeft H.S., Marel G.A. van der, Filippov D.V. & Codee J.D.C. (2019), Synthesis, Reactivity, and Stereoselectivity of 4-Thiofuranosides, Journal of Organic Chemistry (JOC) 84(3): 1218-1227.
- Zom G.G., Willems M.M.J.H.P., Meeuwenoord N., Reintjens N.R.M., Tondini E., Khan S., Overkleeft H.S., Marel G.A. van der, Codée J.D.C., Ossendorp F. & Filippov D.V. (2019), Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells, Bioconjugate Chemistry 30(4): 1150-1161.
- Vorm S. van der, Hansen T., Rijssel E.R. van, Dekkers R., Madern J.M., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codée J.D.C. (2019), Furanosyl oxocarbenium ion Conformational Energy Landscape maps as a tool to study the glycosylation stereoselectivity of 2-azidofuranoses, 2-fluorofuranoses and methyl furanosyl uronates, Chemistry: a European Journal 25(29): 7149-7157.
- Gential G.P.P., Hogervorst T.P., Tondini E., Graaff M.J. van de, Overkleeft H.S., Codée J.D.C., Marel G.A. van der, Ossendorp F. & Filippov D.V. (2019), Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7, Bioorganic and Medicinal Chemistry Letters 29(11): 1340-1344.
- Hansen T., Lebedel L., Remmerswaal W.A., Vorm S. van der, Wander D.P.A., Somers M., Overkleeft H.S., Filippov D.V., Désiré J., Mingot A., Bleriot Y., Marel G.A. van der, Thibaudeau S. & Codée J.D.C. (2019), Defining the SN1 Side of Glycosylation Reactions: Stereoselectivity of Glycopyranosyl Cations, ACS Central Science 5(5): 781-788.
- Ham A. van der, Hansen T., Lodder G., Codée J.D.C., Hamlin T.A. & Filippov D.V. (2019), Computational and NMR Studies on the Complexation of Lithium Ion to 8‐Crown‐4, ChemPhysChem 20(16): 2103-2109.
- Liu Q., Marel G.A. van der & Filippov D.V. (2019), Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose, Organic and Biomolecular Chemistry 17(22): 5460-5474.
- Ando Y., Elkayam E., McPherson R.L., Dasovich M., Cheng S.J., Voorneveld J., Filippov D.V., Ong S.E., Joshua-Tor L. & Leung A.K.L. (2019), ELTA: Enzymatic Labeling of Terminal ADP-Ribose, Molecular Cell 73(4): 845-856.e5.
- Li R.E., Hogervorst T.P., Achilli S., Bruijns S.C., Arnoldus T., Vivès C., Wong C.C., Thépaut M., Meeuwenoord N.J., Elst H Van den, Overkleeft H.S., Marel G.A. van der, Filippov D.V., Vliet S.J. van, Fieschi F., Codee J.D.C. & Kooyk Y. van (2019), Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen, Frontiers in Chemistry 7: 650.
- Zurlo E., Gorroño Bikandi I., Meeuwenoord N.J., Filippov D.V. & Huber M.I. (2019), Tracking amyloid oligomerization with monomer resolution using a 13-amino acid peptide with a backbone-fixed spin label, Physical Chemistry Chemical Physics 21(45): 25187-25195.
- Gracht A.M.F. van der, Geus M.A.R. de, Camps M.G.M., Ruckwardt T.J., Sarris A.J.C., Bremmers J., Maurits E., Pawlak J.B., Posthoorn M.M., Bonger K.M., Filippov D.V., Overkleeft H.S., Robillard M.S., Ossendorp F. & Kasteren S.I. van (2018), Chemical control over T-cell activation in vivo using deprotection of trans-cyclooctene-modified epitopes, ACS Chemical Biology 13(6): 1569-1576.
- Liu Q., Kistemaker H.A.V., Bhogaraju S., Dikic I., Overkleeft H.S., Marel G.A. van der, Ovaa H., Heden van Noort G.J. van der & Filippov D.V. (2018), A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins, Angewandte Chemie (International Edition) 57(6): 1659-1662.
- Engelsma S.B., Ende T.C. van den, Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2018), Reaction Rates of Various N-Acylenamines in the Inverse-Electron-Demand Diels-Alder Reaction, European Journal of Organic Chemistry (20-21): 2587-2591.
- Es D. van der, Berni F., Hogendorf W.F.J., Meeuwenoord N., Laverde D., Diepen A. van, Overkleeft H.S., Filippov D.V., Hokke C.H., Huebner J., Marel G.A. van der & Codée J.D.C. (2018), Streamlined Synthesis and Evaluation of Teichoic Acid Fragments, Chemistry: a European Journal 24(16): 4014-4018.
- Voorneveld J., Rack J.G.M., Ahel I., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2018), Synthetic alpha- and beta-Ser-ADP-ribosylated Peptides Reveal alpha-Ser-ADPr as the Native Epimer, Organic Letters 20(13): 4140-4143.
- Sarris A.J.C., Hansen T., Geus M.A.R. de, Maurits E., Doelman W., Overkleeft H.S., Codée J.D.C., Filippov D.V. & Kasteren S.I. van (2018), Fast and pH-Independent Elimination of trans-Cyclooctene by Using Aminoethyl-Functionalized Tetrazines, Chemistry: a European Journal 24(68): 18075-18081.
- Zom G.G., Willems M.M.J.H.P., Khan S., Sluis T.C. van der, Kleinovink J.W., Camps M.G.M., Marel G.A. van der, Filippov D.V., Melief C.J.M. & Ossendorp F.A. (2018), Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication, Journal for ImmunoTherapy of Cancer 6(1): 146.
- Kistemaker H.A.V., Voorneveld J. & Filippov D.V. (2018), ADPr-Peptide Synthesis. In: Chang P. (Ed.), ADP-ribosylation and NAD+ Utilizing Enzymes. Methods and Protocols. Methods in Molecular Biology no. 1813. New York: Humana Press. 345-369.
- Klimushin D.M., Krasnov A.I., Filippov D.V. & Sharonov N.Y. (2018), Hydrogen pressure, solvent and catalyst nature influence on the 2-chloro-4-nitroaniline hydrogenation regularities, IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA = Russian Journal of Chemistry and Chemical Technology 61(9-10): 30-35.
- Hoang A., Kalashnikova V.A., Lefedova O.V. & Filippov D.V. (2018), Influence of sodium hydroxide additives on hydrogenization kinetics of 4-nitro-2'-hydroxy-5'-metylazobenzene on skeletal nickel in aqueous solution of 2-propanol, IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA = Russian Journal of Chemistry and Chemical Technology 61(8): 66-72.
- Narhe B.D., Breman A.C., Padwal J., Vandenput D.A.L., Scheidt J.M., Benningshof J.C.J., Marel G.A. van der, Overkleeft H.S., Stelt M. van der & Filippov D.V. (2017), Piperidine and octahydropyrano[3,4-c] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory, Bioorganic & Medicinal Chemistry 25(19): 5160-5170.
- Zhang Q., Howell P.L., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codee J.D.C. (2017), Chemical synthesis of guanosine diphosphate mannuronic acid (GDPManA) and its C-4-O-methyl and C-4-deoxy congeners, Carbohydrate Research 450: 12-18.
- Liu Q., Florea B.I. & Filippov D.V. (2017), ADP-Ribosylation Goes Normal: Serine as the Major Site of the Modification, Cell chemical biology 24(4): 431-432.
- Singh H.R., Nardozza A.P., Moller I.R., Knobloch G., Kistemaker H.A.V., Hassler M., Harrer N., Blessing C., Eustermann S., Kotthoff C., Huet S., Mueller-Planitz F., Filippov D.V., Timinszky G., Rand K.D. & Ladurner A.G. (2017), A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene, Molecular Cell 68(5): 860-871.
- Liu Q., Kistemaker H.A.V., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2017), Synthesis of ribosyl-ribosyl-adenosine-5 ',5 '',5'''(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose), Chemical Communications 53(74): 10255-10258.
- Gubbens J., Wu C., Zhu H., Filippov D.V., Florea B.I., Rigali S., Overkleeft H.S. & Wezel G.P. van (2017), Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp MBT76, ACS Chemical Biology 12(11): 2756-2766.
- Bilan V., Selevsek N., Kistemaker H.A.V., Abplanalp J., Feurer R., Filippov D.V. & Hottiger M.O. (2017), New Quantitative Mass Spectrometry Approaches Reveal Different ADP-ribosylation Phases Dependent On the Levels of Oxidative Stress, Molecular and Cellular Proteomics 16(5): 949-958.
- Abplanalp J., Leutert M., Frugier E., Nowak K., Feurer R., Kato J., Kistemaker H.A.V., Filippov D.V., Moss J., Caflisch A. & Hottiger M.O. (2017), Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase, Nature Communications 8: 1-11.
- Engelsma S.B., Meeuwenoord N.J., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2017), Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates, Angewandte Chemie (International Edition) 56(11): 2955-2959.
- Xin B.T., Bruin G. de, Huber E.M., Besse A., Florea B.I., Filippov D.V., Marel G.A. van der, Kisselev A.F., Stelt M. van der, Driessen C., Groll M. & Overkleeft H.S. (2016), Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes, Journal of Medicinal Chemistry 59(15): 7177-7187.
- Willems M.M.J.H.P., Zom G.G., Meeuwenoord N.J., Khan S., Ossendorp F.A., Overkleeft H.S., Marel G.A. van der, Filippov D.V. & Codée J.D.C. (2016), Lipophilic muramyl dipeptide-antigen conjugates as immunostimulating agents, ChemMedChem 11(2): 190-198.
- Pawlak J.B., Hos B.J., Graaff M.J. van de, Megantari O.A., Meeuwenoord N., Overkleeft H.S., Filippov D.V., Ossendorp F. & Kasteren S.I. van. (2016), The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes, ACS Chemical Biology : .
- Gential G.P., Ho N.I., Chiodo F., Meeuwenoord N., Ossendorp F., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2016), Synthesis and evaluation of fluorescent Pam3Cys peptide conjugates, Bioorganic and Medicinal Chemistry Letters 26(15): 3641-5.
- Zom G.G., Welters M.J., Loof N.M., Goedemans R., Lougheed S., Valentijn R.R., Zandvliet M.L., Meeuwenoord N.J., Melief C.J., Gruijl T.D. de, Marel G.A. van der, Filippov D.V., Ossendorp F. & Burg S.H. van der (2016), TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients, OncoTarget : .
- Kistemaker H.A., Nardozza A.P., Overkleeft H.S., Marel G.A. van der, Ladurner A.G. & Filippov D.V. (2016), Synthesis and macrodomain binding of mono-ADP-ribosylated peptides, Angewandte Chemie (International Edition) 55(36): 10634-8.
- Hashemi Shabestari M., Meeuwenoord N.J., Filippov D.V. & Huber M.I. (2016), Interaction of the amyloid β peptide with sodium dodecyl sulfate as a membrane-mimicking detergent, Journal of Biological Physics 42(3): 299-315.
- Krasnov A.I., Latypova A.R., Lefedova O.V., Sharonov N.Y., Efremov E.V. & Filippov D.V. (2016), Kinetics of hydrogenation of nitrobenzene, 4-nitrotuluene, 4-nitroaniline and 2-chloro-4-nitroaniline on supported palladium catalyst, IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA = Russian Journal of Chemistry and Chemical Technology 59(4): 68-72.
- Schein C.H., Ye M., Paul A.V., Oberste M.S., Chapman N., Noort G.J. van, Filippov D.V. & Choi K.H. (2015), Sequence specificity for uridylylation of the viral peptide linked to the genome (VPg) of enteroviruses, Virology 484: 80-85.
- Liu N., Hoogendoorn S., Kar B. van de, Kaptein A., Barf T., Driessen C., Filippov D.V., Marel G.A. van der, Stelt M. van der & Overkleeft H.S. (2015), Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study, Organic and Biomolecular Chemistry 13(18): 5147-5157.
- Padwal J.D., Filippov D.V., Narhe B.D., Aertssen S., Beuving R.J., Benningshof J.C.J., Marel G.A. van der, Overkleeft H.S. & Van der Stelt M. (2015), Cyclopentitol as a scaffold for a natural product-like compound library for drug discovery, Bioorganic & Medicinal Chemistry 23(11): 2650-2655.
- Volbeda A.G., Kistemaker H.A.V., Overkleeft H.S., Marel G.A. van der, Filippov D.V. & Codee J.D.C. (2015), Chemoselective cleavage of p-methoxybenzyl and 2-naphthylmethyl ethers using a catalytic amount of HCl in hexafluoro-2-propanol, Journal of Organic Chemistry (JOC) 80(17): 8796-8806.
- Ouchaou K., Maire F., Salo O., Ali H., Hankemeier T., Marel G.A. van der, Filippov D.V., Bovenberg R.A.L., Vreeken R.J., Driessen A.J.M. & Overkleeft H.S. (2015), A Mutasynthesis Approach with a Penicillium chrysogenum Delta roqA Strain Yields New Roquefortine D Analogues, ChemBioChem 16(6): 915-923.
- Kistemaker H.A.V., Lameijer L.N., Meeuwenoord N.J., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2015), Synthesis of Well-Defined Adenosine Diphosphate Ribose Oligomers, Angewandte Chemie (International Edition) 54(16): 4915-4918.
- Kistemaker H.A.V., Meeuwenoord N.J., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2015), On the synthesis of oligonucleotides interconnected through pyrophosphate linkages, European Journal of Organic Chemistry 2015(27): 6084-6091.
- Rijssel E.R. van, Delft P. van, Marle D.V. van, Bijvoets S.M., Lodder G., Overkleeft H.S., Marel G.A. van der, Filippov D.V. & Codee J.D.C. (2015), Stereoselectivity in the Lewis Acid Mediated Reduction of Ketofuranoses, Journal of Organic Chemistry (JOC) 80(9): 4553-4565.
- Kistemaker H.A.V., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2015), Branching of poly(ADP-ribose): Synthesis of the Core Motif, Organic Letters 17(17): 4328-4331.
- Pawlak J.B., Gential G.P.P., Ruckwardt T.J., Bremmers J.S., Meeuwenoord N.J., Ossendorp F.A., Overkleeft H.S., Filippov D.V. & Kasteren S.I. (2015), Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation, Angewandte Chemie (International Edition) 54(19): 5628-5631.
- Gubbens J., Zhu H., Girard G.A.O., Song L., Florea B.I., Aston P., Ichinose K., Filippov D.V., Young-Hae C., Overkleeft H.S, Challis G.L. & Wezel G.P. van (2014), Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene clusters for different classes of natural products, Chemistry & Biology 21(6): 707-718.
- Liu W.M., Skinner S.P., Timmer M., Blok A., Hass M.A.S., Filippov D.V., Overhand M. & Ubbink M. (2014), A Two-Armed Lanthanoid-Chelating Paramagnetic NMR Probe Linked to Proteins via Thioether Linkages, Chemistry: a European Journal 20(21): 6256-6258.
- Zom G.G., Filippov D.V., Marel G.A. van der, Overkleeft H.S., Melief C.J. & Ossendorp F.A. (2014), Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule, OncoImmunology 3(7): e947892.
- Delft P. van, Witte W.E.A. de, Meeuwenoord N.J., Noort G.J. van der Heden van, Versluis F., Olsthoorn R.R.C.L., Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2014), Design of a ribosyltriazole-annulated cyclooctyne for oligonucleotide labeling by strain-promoted alkyne-azide cycloaddition, European Journal of Organic Chemistry 2014(34): 7566-7571.
- Willems Marian M.J.H.P., Zom Gijs G., Khan Selina, Meeuwenoord Nico, Melief Cornelis J.M., Van der Stelt Mario, Overkleeft Herman S., Codee Jeroen D.C., Van der Marel Gijsbert A., Ossendorp Ferry & Filippov Dmitri V. (2014), N-Tetradecylcarbamyl Lipopeptides as Novel Agonists for Toll-like Receptor 2, Journal of Medicinal Chemistry 57(15): 6873-6878.
- Willems M.M.J.H.P., Zom G.G., Meeuwenoord N., Ossendorp F.A., Overkleeft H.S., Van der Marel G.A., Codee J.D.C. & Filippov D.V. (2014), Design, automated synthesis and immunological evaluation of NOD2-ligand-antigen conjugates, Beilstein Journal of Organic Chemistry 10: 1445-1453.
- Engelsma Sander B., Willems Lianne I., Van Paaschen Claudia E., Van Kasteren Sander I., Van der Marel Gijsbert A., Overkleeft Herman S. & Filippov Dmitri V. (2014), Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels-Alder Ligation, 16(10): 2744-2747.
- Xin Bo-Tao, De Bruin Gerjan, Verdoes Martijn, Filippov Dmitri V., Van der Marel Gijs A. & Overkleeft Herman S. (2014), Exploring dual electrophiles in peptide-based proteasome inhibitors: carbonyls and epoxides, 12(30): 5710-5718.
- Langereis Martijn A., Feng Qian, Nelissen Frank H.T., Virgen-Slane Richard, Heden Van Noort Gerbrand J. van der, Maciejewski Sonia, Filippov Dmitri V., Semler Bert L., Van Delft Floris L. & Van Kuppeveld Frank J.M. (2014), Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA, Nucleic Acids Research 42(4): 2473-2482.
- Zom Gijs G., Khan Selina, Britten Cedrik M., Sommandas Vinod, Camps Marcel G. M., Loof Nikki M., Budden Christina F., Meeuwenoord Nico J., Filippov Dmitri V., Van der Marel Gijsbert A., Overkleeft Hermen S., Melief Cornelis J.M. & Ossendorp Ferry (2014), Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand-Peptide Conjugates, Cancer Immunology Research 2(8): 756-764.
- Van Rijssel Erwin R., Van Delft Pieter, Lodder Gerrit, Overkleeft Herman S., Van der Marel Gijsbert A., Filippov Dmitri V. & Codee Jeroen D.C. (2014), Furanosyl Oxocarbenium Ion Stability and Stereoselectivity, 53(39): 10381-10385.
- Kistemaker Hans A.V., Noort Gerbrand J. van der Heden, Overkleeft Herman S., Van der Marel Gijsbert A. & Filippov Dmitri V. (2013), Stereoselective Ribosylation of Amino Acids, 15(9): 2306-2309.
- Van Noort Gerbrand, Heden J. van der, Schein Catherine H., Overkleeft Herman S., Van der Marel Gijsbert A. & Filippov Dmitri V. (2013), A general synthetic method toward uridylylated picornavirus VPg proteins, 19(6): 333-336.
- Otero Jose M., van der Knaap Matthijs, Llamas-Saiz Antonio L., Van Raaij Mark J., Amorin Manuel, Granja Juan R., Filippov Dmitri V., Van der Marel Gijsbert A., Overkleeft Herman S. & Overhand Mark (2013), Design, Synthesis, and Structural Analysis of Turn Modified cyclo-(alpha beta(3)alpha beta(2)alpha)(2) Peptide Derivatives toward Crystalline Hexagon-Shaped Cationic Nanochannel Assemblies, Crystal Growth & Design 13(10): 4355-4367.
- Hashemi Shabestari M., Plug T., Motazacker M.M., Meeuwenoord N.J., Filippov D.V., Meijers J.C.M. & Huber M.I. (2013), The Aggregation Potential of the 1–15- and 1–16- Fragments of the Amyloid b Peptide and Their Influence on the Aggregation of Ab40, Applied Magnetic Resonance 44: 1167-1179.
- Virgen-Slane R., Rozovics J.M., Fitzgerald K.D., Ngo T., Chou W., Van Noort G.J.V., Filippov D.V., Gershon P.D. & Semler B.L. (2012), An RNA virus hijacks an incognito function of a DNA repair enzyme, Proceedings of the National Academy of Sciences 109(36): .
- Schein C.H., Bowen D.M., Lewis J.A., Choi K., Paul A., Noort G.J.V. van, Lu W.Z. & Filippov D.V. (2012), Physicochemical property consensus sequences for functional analysis, design of multivalent antigens and targeted antivirals, BMC Bioinformatics 13((Suppl 13)): S9.
- Hogendorf W.F.J., Lameijer L.N., Beenakker T.J.M., Overkleeft H.S., Filippov D.V., Codee J.D.C. & Van der Marel G.A. (2012), Fluorous Linker Facilitated Synthesis of Teichoic Acid Fragments, 14(3): .
- Van der Heden Van Noort G.J., Van Delft P., Meeuwenoord N.J., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2012), Fully automated sequential solid phase approach towards viral RNA-nucleopeptides, Chemical Communications 48(65): 8093-8095.
- Shabestari M.H., Meeuwenoord N.J., Filippov D.V. & Huber M.I. (2012), The Effect of a Membrane Mimicking Detergent on Alzheimer's Amyloid Peptide Aggregation Studied by EPR, Biophysical Journal 102: .
- Zom G.G.P., Khan S., Filippov D.V. & Ossendorp F. (2012), TLR Ligand-Peptide Conjugate Vaccines: Toward Clinical Application, Advances in Immunology 114: .
- Hogendorf W.F.J., Kropec A., Filippov D.V., Overkleeft H.S., Huebner J., Van der Marel G.A. & Codee J.D.C. (2012), Light fluorous synthesis of glucosylated glycerol teichoic acids, Carbohydrate Research 356: .
- Van Delft P., Van Schie E., Meeuwenoord N.J., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2011), Oligonucleotide Conjugates by Means of Copper-Free Click Chemistry - Expanding the Repertoire of Strained Cyclooctyne Phosphoramidites, Synthesis Stuttgart (17): .
- Hogendorf W.F.J., Meeuwenoord N.J., Overkleeft H.S., Filippov D.V., Laverde D., Kropec A., Huebner J., Van der Marel G.A. & Codee J.D.C. (2011), Automated solid phase synthesis of teichoic acids, Chemical Communications 47(31): .
- Van Noort G.J.V., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2011), Ribosylation of Adenosine: An Orthogonally Protected Building Block for the Synthesis of ADP-Ribosyl Oligomers, 13(11): .
- Mirabella A.C., Pletnev A.A., Downey S.L., Florea B.I., Shabaneh T.B., Britton M., Verdoes M., Filippov D.V., Overkleeft H.S. & Kisselev A.F. (2011), Specific Cell-Permeable Inhibitor of Proteasome Trypsin-like Sites Selectively Sensitizes Myeloma Cells to Bortezomib and Carfilzomib, Chemistry & Biology 18(5): .
- Shabestari M.H., Sepkhanova I., Drescher M., Meeuwenoord N.J., Limpens R.W.A.L., Koning R.I., Filippov D.V. & Huber M.I. (2010), Monitoring Alzheimer amyloid peptide aggregation by EPR. Annual Dutch Meeting on Molecular and Cellular Biophysics. Veldhoven.
- Van Delft P., Meeuwenoord N.J., Hoogendoorn S., Dinkelaar J., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2010), Synthesis of Oligoribonucleic Acid Conjugates Using a Cyclooctyne Phosphoramidite, 12(23): .
- Van der Heden Van Noort G.J., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2010), Synthesis of nucleotidylated poliovirus VPg proteins, Journal of Organic Chemistry (JOC) 75(16): .
- Van der Heden Van Noort G.J., Van der Horst M.G., Overkleeft H.S., Van der Marel G.A. & Filippov D.V. (2010), Synthesis of mono-ADP-ribosylated oligopeptides using ribosylated amino acid building blocks, Journal of the American Chemical Society 132(14): .
- Boorn J.G. van den, Konijnenberg D., Tjin E.P.M., Picavet D.I., Meeuwenoord N.J., Filippov D.V., Veen J.P.W. van der, Bos J.D., Melief C.J.M. & Luiten R.M. (2010), Effective Melanoma Immunotherapy in Mice by the Skin-Depigmenting Agent Monobenzone and the Adjuvants Imiquimod and CpG, PLoS ONE 5(5): e10626.
- Schein C.H., Oezguen N., Van der Heden van Noort G.J., Filippov D.V., Paul A., Kumar E. & Braun W. (2010), NMR solution structur of poliovirus uridylyated peptide linked to the genome (VPgpU), Peptides 31: .
- Ali A., Berg R.J.B.H.N. van den, Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codee J.D.C. (2009), Methylsulfonylethoxycarbonyl (Msc) and fluorous propylsulfonylethoxycarbonyl (FPsc) as hydroxy-protecting groups in carbohydrate chemistry, Tetrahedron Letters 50(19): 2185-2188.
- Montfoort N. van, Camps MG, Khan S, Filippov D.V., Weterings J.J., Griffith JM, Geuze H.J., Hall T. van, Verbeek J.S., Melief C.J. & Ossendorp F. (2009), Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity, Proceedings of the National Academy of Sciences 106: 6730-6735.
- Weterings J.J., Khan S., Heden Noort G.J. van der, Melief C.J.M., Overkleeft H.S., Burg S.H. van der, Ossendorp F., Marel G.A. van der & Filippov D.V. (2009), 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation, Bioorganic and Medicinal Chemistry Letters 19(8): 2249-2251.
- Ghisaidoobe A.B.T., Koning M.C. de, Duynstee H.I., Kortenaar P.B.W., Overkleeft H.S., Filippov D.V. & Marel G.A. van der (2008), A two-step sulfurization for efficient solution-phase synthesis of phosphorothioate oligonucleotides, Tetrahedron Letters 49: 3129-3132.
- Verdoes M., Florea B.I., Hillaert U., Willems L.M., Linden W.A. van der, Sae-Heng M., Filippov D.V., Kisselev A.F., Marel G.A. van der & Overkleeft H.S. (2008), Azido-BODIPY acid reveals quantitative Staudinger-Bertozzi ligation in two-step activity based proteasome profiling, ChemBioChem 9: 1735-1738.
- Heden G.J., Noort C.P. van, Verhagen C.P., Horst M.G. van der, Overkleeft H.S., Marel G.A. van der & Filippov D.V. (2008), A versatile one-pot procedure to phosphate monoesters and pyrophosphates using di(p-methoxybenzyl)-N,N-diisopropylphosphoramidite, 10: 4461-4464.
- Khan S., Weterings J.J., Britten C.M., Jong A.R. de, Graafland D., Melief C.J.M., Burg S.H. van der, Marel G.A. van der, Overkleeft H.S., Filippov D.V. & Ossendorp F.A. (2008), Chirality of TLR-2 ligand Pam(3)CysSK(4) in fully synthetic peptide conjugates critically influences the induction of specific CD8(+) T-cells, Molecular Immunology : .
- Filippov D.V., Dienwiebel M., Frenken J.W.M., Klafter J. & Urbakh M. (2008), Torque and twist against superlubricity, Physical Review Letters 100: 046102.
- Gold H., Delft P. van, Meeuwenoord N.J., Codee J.D.C., Filippov D.V., Eggink G., Overkleeft H.S. & Marel G.A. van der (2008), Synthesis of Sugar Nucleotides by Application of Phosphoramidites, Journal of Organic Chemistry (JOC) 73: 9458-9460.
- Malta E., Verhagen C.P., Moolenaar G.F., Filippov D.V., Marel G.A. van der & Goosen N. (2008), Functions of base flipping in E. coli nucleotide excision repair, DNA Repair 7: 1647-1658.
- Bonger K.M., Wennekes T., Filippov D.V., Lodder G., Marel G.A. van der & Overkleeft H.S. (2008), The effect of Lewis acids on the stereochemistry in the Ugi three-component reaction with D-lyxo pyrroline, European Journal of Organic Chemistry : 3678-3688.
- Khan S., Bijker M.S., Weterings J.J., Tanke H.J., Adema G.J., Hall T. van, Drijfhout J.W., Melief C.J.M., Overkleeft H.S., Marel G.A. van der, Filippov D.V., Burg M.J.M. van der & Ossendorp F. (2007), Distinct Uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells, Journal of Biological Chemistry 282(29): 21145-21159.
- Agrawal P.R., Hofmann M.W., Meeuwenoord N.J., Fillipov D.V., Stalz H., Hulsbergen F.B., Langosch D., Overkleeft H.S. & Groot H.J.M. de (2007), Solid-phase synthesis and purification of a set of uniformly 13C, 15N labelled de novo designed membrane fusogenic peptides, Journal of Peptide Science 13(2): 75-80.
- Filippov D.V. (2007), Chemical synthesis of the HPV16 E7 protein, Tetrahedron Letters 47(52): 9349-9352.
- Weterings J.J., Khan S., Kriek N.M.A., Van der Marel G.A., Overkleeft H.S., Ossendorp F., Van der Burg S.H., Drijfhout J.W. & Filippov D.V. (2007), Synthesis of modified and hybrid protein derived biopolymers, Biopolymers 88(4): 576-576.
- Weterings J.J., Khan S., Heden G.J., Drijfhout J.W., Melief C.J.M., Overkleeft H.S., Burg S.H. van der, Ossendorp F.A., Marel G.A. van der & Filippov D.V. (2006), Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines, Bioorganic and Medicinal Chemistry Letters 16(12): 3258-3261.
- Verdoes M., Koning M.C. de, Ghisaidoobe A.B.T., Duynstee H.I., Kortenaar P.B.W., Filippov D.V. & Marel G.A. van der (2006), Simple and efficient solution-phase synthesis of oligonucleotides using extractive work-up, Organic Process Research & Development 10: 1238-1245.
- Kriek N.M.A.J., Meeuwenoord N.J., Elst H. van den, Heus H.A., Marel G.A. van der & Filippov D.V. (2006), Chemical synthesis of picornaviral protein primers of RNA replication, ORGANIC & BIOMOLECULAR CHEMISTRY 4: 3576-3586.
- Tuin A.W., Siegal G.D., Marel G.A. van der, Overkleeft H.S. & Filippov D.V. (2006), Facile synthesis and application of uniformly-13C, 15N - labeled phosphotyrosine for ligand binding studies, Bioorganic and Medicinal Chemistry Letters 16(14): 3806-3808.
- Verdoes M., Florea B.I., Menendez-Benito V., Maynard C.J., Witte M.D., Van der Linden W.A., Van den Nieuwendijk A.M., Hofmann T., Berkers C.R., Van Leeuwen F.W., Groothuis T.A., Leeuwenburgh M.A., Ovaa H., Neefjes J.J., Filippov D.V., Van der Marel G.A., Dantuma N.P. & Overkleeft H.S. (2006), A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo, Chemistry & Biology 13(11): 1217-1226.
- Koning M.C. de, Petersen L., Weterings J.J., Overhand M., Marel G.A. van der & Filippov D.V. (2006), Synthesis of thiol-modified peptide nucleic acids designed for post-assembly conjugation reactions, Tetrahedron 62: 3248-3258.
- Filippov D.V. (2006), Chemical synthesis of the HPV16 E7 protein, Tetrahedron Letters 47: 9349-9352.
- Filippov D.V., Welters M.J.P., Valentijn A.R.P.M., Melief C.J.M., Marel G.A. van der, Burg S.H. van der, Overkleeft H.S. & Drijfhout J.W. (2006), Chemical synthesis of the HPV16 E7 protein, Tetrahedron Letters 47(52): 9349-9352.
- Litjens R.E.J.N., Hoogerhout P., Filippov D.V., Codee J.D.C., Bos L.J. van den, Berg R.J.B.H.N. van den, Overkleeft H.S. & Marel G.A. van der (2005), Synthesis of an alpha-Gal epitope alpha-D-Galp-(1 -> 3)-beta-D-Galp-(1 -> 4)-beta-D-Glcp NAc-lipid conjugate, Journal of Carbohydrate Chemistry 24(7): 755-769.
- Timmer M.S.M., Risseeuw M.D.P., Verdoes M., Filippov D.V., Palisier J.R., Marel G.A. van der, Overkleeft H.S. & Boom J.H. van (2005), Synthesis of functionalized heterocycles via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction, Tetrahedron Asymmetry 16: 177-185.
- Voerman G., Cavalli S., Marel G.A. van der, Pfleiderer W., Boom J.H. van & Filippov D.V. (2005), Dimethyllumazine derivatives from Limnatis nilotica, 68: 938-941.
- Vanwetswinkel S., Heetebrij R.J., Duynhoven J. van, Hollander J.G., Filippov D.V., Hajduk P.J. & Siegal G.D. (2005), TINS, Target Immobilized NMR Screening: an efficient and sensitive method for ligand discovery, Chemistry & Biology 12(2): 207-216.
- Koning M.C. de, Knaap M.S. van der, Petersen L., Elst H. van den, Marel G.A. van der, Overhand M. & Filippov D.V. (2005), Reactivity of PNA thioesters in chemical ligation reactions, SYNLETT 6: 595-598.
- Welters M.J., Filippov D.V., Eeden S.J.F. van den, Franken K.L.M.C., Nouta J., Valentijn A.R.P.M., Marel G.A. van der & Overkleeft H.S. (2004), Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV 16 E7 in the TC-1 mouse tumour model, Vaccine 23(3): 305-311.
- Visser P.C. de, Helden M. van, Filippov D.V., Marel G.A. van der, Drijfhout J.W., Boom J.H. van, Noort D. & Overkleeft H.S. (2003), A novel, base-labile fluorous amine protecting group: synthesis and use as a tag in the purification of synthetic peptides, Tetrahedron Letters 44: 9013-9016.
- Kriek N.M.A.J., Kelly P., Filippov D.V., Meeuwenoord N.J., Marel G.A. van der, Overhand M., Boom J.H. van, Valentijn A. & Overkleeft H.S. (2003), Synthesis of novel tetrahydropyran-based dipeptide isosters by Overman rearrangement of 2,3-didehydroglycosides, European Journal of Organic Chemistry : 2418-2427.
- Kriek N.M.A.J., Filippov D.V., Elst H. van den, Meeuwenoord N.J., Tesser G.I., Boom J.H. van & Marel G.A. van der (2003), Stepwise solid phasae synthesis of uridylylated viral genome-linked peptides using uridylylated amino acid building blocks, Tetrahedron 59: 1589-1597.
- Visser P.C. de, Kriek N.M.A.J., Hooft P.A.V. van, Schepdael A., Filippov D.V., Marel G.A. van der, Overkleeft H.S., Boom J.H. van & Noort D. (2003), Solid-phase synthesis of polymyxin B-1 and analogues via a safety-catch approach, JOURNAL OF PEPTIDE SCIENCE 61: 298-306.
- Koning M.C. de, Filippov D.V., Marel G.A. van der, Boom J.H. van & Overhand M. (2003), Synthesis of macrocyclic peptide nucleic acid derivatives via intramolecular chemical ligation, Tetrahedron Letters 44: 7597-7600.
- Filippov D.V., Zoelen D.J., Oldfield S.P., Marel G.A. van der, Overkleeft H.S., Drijfhout J.W. & Kluin-Nelemans J.C. (2003), Fluorophilic tagging reagents for solid phase peptide synthesis, Biopolymers 71: 191.
- Visser P.C. de, Helden M. van, Filippov D.V., Marel G.A. van der, Drijfhout J.W., Boom J.H. van, Noort D. & Overkleeft H.S. (2003), A novel, base-labile fluorous amine protecting group: synthesis and use as a tag in the purification of synthetic peptide, Tetrahedron Letters : 9013-9016.
- Sakharov D., Jie A.F.H., Filippov D.V., Bekkers M., Boom J.H. van & Rijken D.C. (2003), Binding and retention of polycationic peptides and dendrimers in the vascular wall, FEBS Letters 537: 6-10.
- Kriek N.M.A.J., Filippov D.V., Elst H. van den, Meeuwenoord N.J., Tesser G.I., Boom J.H. van & Marel G.A. van der (2003), Stepwise solid phase synthesis of uridylylated viral genome-linked peptides using uridylylated amino acid building blocks, Tetrahedron 59(9): 1589-1597.
- Luca S.M., White J.F., Sohal A.K., Filippov D.V., Boom J.H. van, Grisshammer R. & Baldus M. (2003), Studying the conformation of neurotensin bound to Its G- protein-coupled receptor NTS-1 by 2D solid-state NMR, Biophysical Journal 84: 137A.
- Luca S.M., White J.F., Sohal A.K., Filippov D.V., Boom J.H. van, Grisshammer R. & Baldus M. (2003), The conformation of neurotensin bound to its G protein-coupled receptor, Proc. Natl. Acad. Sci. 100: 10706-10711.
- Sakharov D., Jie A.F.H., Filippov D.V., Bekkers M.E.A., Boom J.H. van & Rijken D.C. (2003), Binding and retention of polycationic peptides and dendrimers in the vascular wall, 537: 6-10.
- Burg D., Filippov D.V., Hermanns R.C.A., Marel G.A. van der, Boom J.H. van & Mulder G.J. (2002), Peptidomimetic glutathione analogues as novel γGT stable GST inhibitors, Bioorganic & Medicinal Chemistry 10: 195-205.
- Filippov D.V., Zoelen D.J., Oldfield S.P., Marel G. van der, Overkleeft H.S., Drijfhout J.W. & Boom J. van der (2002), Use of benzyloxycarbonyl(Z)-based fluorophilic tagging reagents in the purification of synthetic peptides, Tetrahedron Letters 43: 7809-7812.
- Koning M.C. de, Filippov D.V., Meeuwenoord N.J., Overhand M., Marel G.A. van der & Boom J.H. van (2002), An approach to the synthesis of peptide-PNA-peptide conjugates via native ligation, Tetrahedron Letters 43: 8173-8176.
- Filippov D.V., Zoelen D.J., Oldfield S.P., Marel G.A. van der, Overkleeft H.S., Drijfhout J.W. & Boom J.H. van (2002), Use of benzyloxycarbonyl (Z)-based fluorophilic tagging reagents in the purification of synthetic peptides, Tetrahedron Letters 43: 7809-7812.
- Burg D., Filippov D.V., Hermanns R.C.A., Marel G.A. van der, Boom J.H. van & Mulder G.J. (2002), Peptidomimetic glutathione analogues as novel gamma GT stable GST inhibitors, Bioorganic & Medicinal Chemistry 10: 195-205.
- Burg D., Hameetman L., Filippov D.V., Marel G.A. van der & Mulder G.J. (2002), Inhibition of glutathione S-transferase in rat hepatocytes by a glycine-tetrazole modified S-alkyl-GSH analogue, Bioorganic and Medicinal Chemistry Letters 12: 1579-1582.
- Turner J.J.C., Sikkema F.D., Filippov D.V., Marel G.A. van der & Boom J.H. van (2001), Synthesis of beta-lactams via ring opening of a serine derived aziridine, SYNLETT 11: 1727-1730.
- Luca S.M., Filippov D.V., Boom J.H. van, Oschkinat H., Groot H.J.M. de & Baldus M. (2001), Secondary chemical shifts in immobilized peptides and proteins: a qualitative basis for structure refinement under Magic Angle Spinning, Journal of Biomolecular NMR 20(4): 325-331.
- Koning M.C. de, Filippov D.V., Meeuwenoord N.J., Overhand M., Marel G.A. van der & Boom J.H. van (2001), Synthesis of a PNA-peptide conjugate by chemical ligation, SYNLETT 10: 1516-1518.
- Timmer M.S.M., Filippov D.V., Marel G.A. van der & Boom J.H. van (2001), Synthesis of phosphorus mono- and bicycles by catalytic ring-closure metathesis, Tetrahedron Letters 42: 8231-8233.
- Turner J.J.C., Filippov D.V., Overhand M., Marel G.A. van der & Boom J.H. van (2001), Synthesis of novel amino acid carbohydrate hybrids via Mitsunobu glycosylation of nitrobenzenesulfonamides, Tetrahedron Letters 42: 5763-5767.
- Schmidt K., Sigel R.K.O., Filippov D.V., Marel G.A. van der, Lippert B. & Reedijk J. (2000), Hydrogen bonding between adenine and 2,4-difluorotoluene is definitely not present, as shown by concentration-dependent NMR studies, New Journal of Chemistry 24(4): 195-197.
- Schmidt K., Filippov D.V., Meeuwenoord N.J., Marel G.A. van der, Boom J.H. van, Lippert B. & Reedijk J. (2000), Solid-phase synthesis of a monofunctional trans-a(2)Pt(II) complex tethered to a single-stranded oligonucleotide, Angewandte Chemie (International Edition) 39(2): 375-377.
- Timmer M.S.M., Ovaa H., Filippov D.V., Marel G.A. van der & Boom J.H. van (2000), An expeditious route to phosphorus heterocycles based on ring-closing metathesis, Tetrahedron Letters 41: 8635-8638.
- Filippov D.V., Kuyl-Yeheskiely E., Marel G.A. van der, Tesser G.I. & Boom J.H. van (1998), Synthesis of a nucleopeptide fragment from poliovirus genome, Tetrahedron Letters 19: 3597-3600.
- Filippov D.V. (24 November 1998), Phosphoramidites in the synthesis of biologically relevant compounds (Dissertatie, Leiden University). Supervisor(s): Boom J.H. van & Marel G.A. van der.
- Filippov D.V., Timmers C.M., Roerdink A.R., Marel G.A. van der & Boom J.H. van (1998), Synthesis of the antibiotically active part of agrocin 84, Tetrahedron Letters 39: 4891-4894.
- Paul A.V., Boom J.H. van, Filippov D.V. & Wimmer E. (1998), Protein-primed RNA synthesis by purified poliovirus RNA polymerase, 393: 280-283.