Cornelis Hokke
Professor Glycobiology of host-pathogen-interaction
- Name
- Prof.dr. C.H. Hokke
- Telephone
- +31 71 526 5065
- c.h.hokke@lumc.nl
- ORCID iD
- 0000-0003-3545-7804
Cornelis H. (Ron) Hokke is professor of Glycobiology of Host-Pathogen Interaction and scientific staff member of the department of Parasitology at the Leiden University Medical Center
Glycobiology of host-pathogen interaction
All pathogens, ranging from the smallest microbe to the largest parasitic worm, interact with their human host at the molecular level through carbohydrate chains (glycans) and glycoconjugates. Our immune system responds to glycans of bacteria or parasites, and some viruses use glycans on the surface of our cells to adhere to. Glycans and their binding partners such as lectins or antibodies therefore play an essential role in infection. This also implies that glycans are important targets for the development of therapeutics, vaccines and diagnostics. This fascinating and innovative field of research is the main focus of my chair: the glycobiology of host-pathogen interaction.
My main research lines aim at the development of glycoconjugate based vaccines and diagnostics for worldwide important helminth infections such as schistosomiasis, and at the identification of immunomodulatory parasite-derived glycoconjugates for the development of novel therapeutics for inflammatory or allergic diseases.
Academic career
Cornelis Hokke studied chemistry at Utrecht University, and obtained his PhD at the same university. The title of his PhD thesis (1993) is ‘Structure determination of glycoprotein glycans’. Subsequently, complementing his biochemical training, he further developed his interests in the medical glycobiology at the Vrije Universiteit Amsterdam. Just before the year 2000 he joined the department of Parasitology at the LUMC to apply his glycobiological expertise in the field of parasitic infections, and developed his fascination for the glycobiology of host-pathogen interaction. In March 2017 he was appointed the professor chair with the same title.
Prizes and honourable appointments
Cornelis Hokke authored >125 peer reviewed publications on glycobiology and/or parasitology research. Cornelis Hokke was chairman of the Netherlands Society for Glycobiology from 2007-2011. He is and was (co-)organiser of a multitude of national and international symposia in the fields of glycobiology and of parasitology. Currently he is editorial board member of the Glycoconjugate Journal and of Parasitology International, further underlining the his unique combined expertise in these two fields of research.
More information
https://www.lumc.nl/org/parasitologie/research/glycobiology/
Professor Glycobiology of host-pathogen-interaction
- Faculteit Geneeskunde
- Divisie 2
- Infectious Diseases
- Parasitologie
- Meulah, B.; Oyibo, P.; Hoekstra, P.T.; Moure, P.A.N.; Maloum, M.N.; Laclong-Lontchi, R.A.; Honkpehedji, Y.J.; Bengtson, M.; Hokke, C.; Corstjens, P.L.A.M.; Agbana, T.; Diehl, J.C.; Adegnika, A.A. & Lieshout, L. van (2024), Validation of artificial intelligence-based digital microscopy for automated detection of Schistosoma haematobium eggs in urine in Gabon, PLoS Neglected Tropical Diseases 18(2).
- Kuipers, M.E.; Nguyen, D.L.; Diepen, A. van; Mes, L.; Bos, E.; Koning, R.I.; Nolte-'t Hoen, E.N.M.; Smits, H.H. & Hokke, C.H. (2023), Life stage-specific glycosylation of extracellular vesicles from Schistosoma mansoni schistosomula and adult worms drives differential interaction with C-type lectin receptors DC-SIGN and MGL, Frontiers in Molecular Biosciences 10.
- White, R.; Sotillo, J.; Ancarola, M.E.; Borup, A.; Boysen, A.T.; Brindley, P.J.; Buzas, E.I.; Cavallero, S.; Chaiyadet, S.; Chalmers, I.W.; Cucher, M.A.; Dagenais, M.; Davis, C.N.; Devaney, E.; Duque-Correa, M.A.; Eichenberger, R.M.; Fontenla, S.; Gasan, T.A.; Hokke, C.H.; Kosanovic, M.; Kuipers, M.E.; Laha, T.; Loukas, A.; Maizels, R.M.; Marcilla, A.; Mazanec, H.; Morphew, R.M.; Neophytou, K.; Nguyen, L.T.; Nolte-'t Hoen, E.; Povelones, M.; Robinson, M.W.; Rojas, A.; Schabussova, I.; Smits, H.H.; Sungpradit, S.; Tritten, L.; Whitehead, B.; Zakeri, A.; Nejsum, P.; Buck, A.H. & Hoffmann, K.F. (2023), Special considerations for studies of extracellular vesicles from parasitic helminths, Journal of Extracellular Vesicles 12(1).
- Petralia, L.M.C.; Diepen, A. van; Nguyen, D.L.; Lokker, L.A.; Sartono, E.; Bennuru, S.; Nutman, T.B.; Pfarr, K.; Hoerauf, A.; Wanji, S.; Foster, J.M. & Hokke, C.H. (2023), Unraveling cross-reactivity of anti-glycan IgG responses in filarial nematode infections, Frontiers in Immunology 14.
- Koopman, J.P.R.; Houlder, E.L.; Janse, J.J.; Casacuberta-Partal, M.; Lamers, O.A.C.; Sijtsma, J.C.; Dood, C. de; Hilt, S.T.; Ozir-Fazalalikhan, A.; Kuiper, V.P.; Roozen, G.V.T.; Bes-Roeleveld, L.M. de; Kruize, Y.C.M.; Wammes, L.J.; Smits, H.H.; Lieshout, L. van; Dam, G.J. van; Amerongen-Westra, I.M. van; Meij, P.; Corstjens, P.L.A.M.; Jochems, S.P.; Diepen, A. van; Yazdanbakhsh, M.; Hokke, C.H. & Roestenberg, M. (2023), Safety and infectivity of female cercariae in Schistosoma- naïve, healthy participants, EBioMedicine 97.
- Meulah, B.; Bengtson, M.; Lieshout, L.V.; Hokke, C.H.; Kreidenweiss, A.; Diehl, J.C.; Adegnika, A.A. & Agbana, T.E. (2023), A review on innovative optical devices for the diagnosis of human soil-transmitted helminthiasis and schistosomiasis, Parasitology 150(2): 137-149.
- Chayé, M.A.M.; Gasan, T.A.; Ozir-Fazalalikhan, A.; Scheenstra, M.R.; Zawistowska-Deniziak, A.; Hengel, O.R.J. van; Gentenaar, M.; Manurung, M.D.; Harvey, M.R.; Codée, J.D.C.; Chiodo, F.; Heijke, A.M.; Kalinowska, A.; Diepen, A. van; Hensbergen, P.J.; Yazdanbakhsh, M.; Guigas, B.; Hokke, C.H. & Smits, H.H. (2023), Schistosoma mansoni egg-derived thioredoxin and Sm14 drive the development of IL-10 producing regulatory B cells, PLoS Neglected Tropical Diseases 17(6).
- Meulah, B.; Oyibo, P.; Bengtson, M.; Agbana, T.; Lontchi, R.A.L.; Adegnika, A.A.; Oyibo, W.; Hokke, C.H.; Diehl, J.C. & Lieshout, L. van (2022), Performance evaluation of the schistoscope 5.0 for (semi-)automated digital detection and quantification of schistosoma haematobium eggs in urine, The American Journal of Tropical Medicine and Hygiene 107(5): 1047-1054.
- Fossa, S.L.; Anton, B.P.; Boisvert, M.L.; Petralia, L.M.C.; Kneller, D.W.; Ganatra, M.B.; Hokke, C.H.; Foster, J.M. & Taron, C.H. (2022), A novel family of sugar-specific phosphodiesterases that remove zwitterionic modifications of N-acetylglucosamine, Glycobiology 32(11): 976-977.
- Hulme, B.J.; Geyer, K.K.; Forde-Thomas, J.E.; Padalino, G.; Phillips, D.W.; Ittiprasert, W.; Karinshak, S.E.; Mann, V.H.; Chalmers, I.W.; Brindley, P.J.; Hokke, C.H. & Hoffmann, K.F. (2022), Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production, PLoS Pathogens 18(1).
- Crosnier, C.; Hokke, C.H.; Protasio, A.V.; Brandt, C.; Rinaldi, G.; Langenberg, M.C.C.; Clare, S.; Janse, J.J.; Wilson, S.; Berriman, M.; Roestenberg, M. & Wright, G.J. (2022), Screening of a library of recombinant Schistosoma mansoni proteins with sera from murine and human controlled infections identifies early serological markers, The Journal of Infectious Diseases 225(8): 1435-1446.
- Kuipers, M.E.; Koning, R.I.; Bos, E.; Hokke, C.H.; Smits, H.H. & Nolte-'t Hoen, E.N.M. (2022), Optimized protocol for the isolation of extracellular vesicles from the parasitic worm Schistosoma mansoni with improved purity, concentration, and yield, Journal of Immunology Research 2022.
- Petralia, L.M.C.; Diepen, A. van; Lokker, L.A.; Nguyen, D.L.; Sartono, E.; Khatri, V.; Kalyanasundaram, R.; Taron, C.H.; Foster, J.M. & Hokke, C.H. (2022), Mass spectrometric and glycan microarray-based characterization of the filarial nematode Brugia malayi glycome reveals anionic and zwitterionic glycan antigens, Molecular & Cellular Proteomics 21(5).
- Pongracz, T.; Nouta, J.; Wang, W.J.; Meijgaarden, K.E. van; Linty, F.; Vidarsson, G.; Joosten, S.A.; Ottenhoff, T.H.M.; Hokke, C.H.; Vries, J.J.C. de; Arbous, S.M.; Roukens, A.H.E.; Wuhrer, M.; BEAT-COVID Grp & COVID-19 Grp (2022), Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19, EBioMedicine 78.
- Huettner, I.; Krumm, S.A.; Serna, S.; Brzezicka, K.; Monaco, S.; Walpole, S.; Diepen, A. van; Allan, F.; Hicks, T.; Kimuda, S.; Emery, A.M.; Landais, E.; Hokke, C.H.; Angulo, J.; Reichardt, N.; Doores, K.J.; IAVI Protocol C Investigators & IAVI African HIV Res Network (2022), Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans, Cell Reports 38(13).
- Petralia, L.M.C.; Santha, E.; Behrens, A.J.; Nguyen, D.L.; Ganatra, M.B.; Taron, C.H.; Khatri, V.; Kalyanasundaram, R.; Diepen, A. van; Hokke, C.H. & Foster, J.M. (2022), Alteration of rhesus macaque serum N-glycome during infection with the human parasitic filarial nematode Brugia malayi, Scientific Reports 12(1).
- Meulah, B.; Bengtson, M.; Lieshout, L.V.; Hokke, C.H.; Kreidenweiss, A.; Diehl, J.C.; Adegnika, A.A. & Agbana, T.E. (2022), A review on innovative optical devices for the diagnosis of human soil-transmitted helminthiasis and schistosomiasis, Parasitology 150(2).
- Nkurunungi, G.; Mpairwe, H.; Versteeg, S.A.; Diepen, A. van; Nassuuna, J.; Kabagenyi, J.; Nambuya, I.; Sanya, R.E.; Nampijja, M.; Serna, S.; Reichardt, N.C.; Hokke, C.H.; Webb, E.L.; Ree, R. van; Yazdanbakhsh, M. & Elliott, A.M. (2021), Cross-reactive carbohydrate determinant-specific IgE obscures true atopy and exhibits alpha-1,3-fucose epitope-specific inverse associations with asthma, Allergy 76(1): 233-246.
- Tanaka, M.; Kildemoes, A.O.; Chadeka, E.A.; Cheruiyot, B.N.; Sassa, M.; Moriyasu, T.; Nakamura, R.; Kikuchi, M.; Fujii, Y.; Dood, C.J. de; Corstjens, P.L.A.M.; Kaneko, S.; Maruyama, H.; Njenga, S.M.; Vrueh, R. de; Hokke, C.H. & Hamano, S. (2021), Potential of antibody test using Schistosoma mansoni recombinant serpin and RP26 to detect light-intensity infections in endemic areas, Parasitology International 83.
- Kildemoes, A.O.; Veldhuizen, T.; Tanaka, M.; Lieshout, L. van; Camprubí-Ferrer, D.; Munoz, J.; Clerinx, J.; Visser, L.; Hamano, S.; Njenga, S.M.; Roestenberg, M.; Diepen, A. van & Hokke, C.H. (2021), DIMINISHING CROSS-REACTIVITY IN SCHISTOSOMIASIS SEROLOGY BY APPLYING A SINGLE GLYCAN TARGET APPROACH, American Journal of Tropical Medicine and Hygiene 105(5): 412-412.
- Huettner, I.; Krumm, S.; Landais, E.; Brzezicka, K.; Serna, S.; Diepen, A. van; Angulo, J.; Allan, F.; Emery, A.; Reichardt, N.; Hokke, R.; Poignard, P. & Doores, K. (2021), Cross-reactivity between HIV-1 bnAbs and parasite glycans, Journal of the International AIDS Society 24.
- Casacuberta-Partal, M.; Lieshout, L. van; Diepen, A. van; Sijtsma, J.C.; Ozir-Fazalalikhan, A.; Koopman, J.P.R.; Dood, C.J. de; Corstjens, P.L.A.M.; Dam, G.J. van; Hokke, C.H. & Roestenberg, M. (2021), Excretion patterns of Schistosoma mansoni antigens CCA and CAA by adult male and female worms, using a mouse model and ex vivo parasite cultures, Parasitology 149(3).
- Pearson, M.S.; Tedla, B.A.; Mekonnen, G.G.; Proietti, C.; Becker, L.; Nakajima, R.; Jasinskas, A.; Doolan, D.L.; Amoah, A.S.; Knopp, S.; Rollinson, D.; Ali, S.M.; Kabole, F.; Hokke, C.H.; Adegnika, A.A.; Field, M.A.; Dam, G. van; Corstjens, P.L.A.M.; Mduluza, T.; Mutapi, F.; Oeuvray, C.; Greco, B.; Chaiyadet, S.; Laha, T.; Cai, P.F.; McManus, D.P.; Bottazzi, M.E.; Felgner, P.L.; Sotillo, J. & Loukas, A. (2021), Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis, The Lancet Microbe 2(11): E617-E626.
- Alvisi, N.; Noort, K. van; Dwiani, S.; Geschiere, N.; Sukarta, O.; Varossieau, K.; Nguyen, D.L.; Strasser, R.; Hokke, C.H.; Schots, A. & Wilbers, R.H.P. (2021), Beta-hexosaminidases along the secretory pathway of nicotiana benthamiana have distinct specificities toward engineered helminth N-glycans on recombinant glycoproteins, Frontiers in Plant Science 12.
- Berni, F.; Kalfopoulou, E.; Cardells, A.M.G.; Carboni, F.; Es, D. van der; Romero-Saavedra, F.; Laverde, D.; Miklic, K.; Malic, S.; Rovis, T.L.; Jonjic, S.; Ali, S.; Overkleeft, H.S.; Hokke, C.H.; Diepen, A. van; Adamo, R.; Jimenez-Barbero, J.; Marel, G.A. van der; Huebner, J. & Codee, J.D.C. (2021), Epitope recognition of a monoclonal antibody raised against a synthetic glycerol phosphate based teichoic acid, ACS Chemical Biology 16(8): 1344-1349.
- Berni, F.; Wang, L.M.; Kalfopoulou, E.; Nguyen, D.L.; Es, D. van der; Huebner, J.; Overkleeft, H.S.; Hokke, C.H.; Marel, G.A. van der; Diepen, A. van & Codee, J.D.C. (2021), Generation of glucosylated sn-1-glycerolphosphate teichoic acids, RSC Chemical Biology 2(1): 187-191.
- Morelli, L.; Lay, L.; Santana-Mederos, D.; Valdes-Balbin, Y.; Bencomo, V.V.; Diepen, A. van; Hokke, C.H.; Chiodo, F. & Compostella, F. (2021), Glycan array evaluation of synthetic epitopes between the capsular polysaccharides from Streptococcus pneumoniae 19F and 19A, ACS Chemical Biology 16(9): 1671-1679.
- Casacuberta-Partal, M.; Beenakker, M.; Dood, C. de; Hoekstra, P.; Kroon, L.; Kornelis, D.; Corstjens, P.; Hokke, C.H.; Dam, G. van; Roestenberg, M. & Lieshout, L. van (2021), Specificity of the point-of-care urine strip test for schistosoma circulating cathodic antigen (POC-CCA) tested in non-endemic pregnant women and young children, American Journal of Tropical Medicine and Hygiene 104(4): 1412--1417.
- Harvey, M.R.; Chiodo, F.; Noest, W.; Hokke, C.H.; Marel, G.A. van der & Codee, J.D.C. (2021), Synthesis and antibody binding studies of schistosome-derived oligo-alpha-(1-2)-l-fucosides, Molecules 26(8).
- Zande, H.J.P. van der; Gonzalez, M.A.; Ruiter, K. de; Wilbers, R.H.P.; Garcia-Tardon, N.; Huizen, M. van; Noort, K. van; Pelgrom, L.R.; Lambooij, J.M.; Zawistowska-Deniziak, A.; Otto, F.; Ozir-Fazalalikhan, A.; Willigen, D. van; Welling, M.; Poles, J.; Leeuwen, F. van; Hokke, C.H.; Schots, A.; Yazdanbakhsh, M.; Loke, P. & Guigas, B. (2021), The helminth glycoprotein omega-1 improves metabolic homeostasis in obese mice through type 2 immunity-independent inhibition of food intake, The FASEB Journal 35(2).
- Kuipers, M.E.; Nolte-'t Hoen, E.N.M.; Ham, A.J. van der; Ozir-Fazalalikhan, A.; Nguyen, D.L.; Korne, C.M. de; Koning, R.I.; Tomes, J.J.; Hoffmann, K.F.; Smits, H.H. & Hokke, C.H. (2020), DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells, Journal of Extracellular Vesicles 9(1).
- Langenberg, M.C.C.; Hoogerwerf, M.A.; Koopman, J.P.R.; Janse, J.J.; Oosterhoud, J.K.V.; Feijt, C.; Jochems, S.P.; Dood, C.J. de; Schuijlenburg, R. van; Ozir-Fazalalikhan, A.; Manurung, M.D.; Sartono, E.; Beek, M.T. van der; Winkel, B.M.F.; Verbeek-Menken, P.H.; Stam, K.A.; Leeuwen, F.W.B. van; Meij, P.; Diepen, A. van; Lieshout, L. van; Dam, G.J. van; Corstjens, P.L.A.M.; Hokke, C.H.; Yazdanbakhsh, M.; Visser, L.G. & Roestenberg, M. (2020), A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics, Nature Medicine 26(3): 326-+.
- Noort, K. van; Nguyen, D.L.; Kriechbaumer, V.; Hawes, C.; Hokke, C.H.; Schots, A. & Wilbers, R.H.P. (2020), Functional characterization of Schistosoma mansoni fucosyltransferases in Nicotiana benthamiana plants, Scientific Reports 10(1).
- Hoffmann, K.F.; Hokke, C.H.; Loukas, A. & Buck, A.H. (2020), Helminth extracellular vesicles: great balls of wonder, International Journal for Parasitology 50(9): 621-622.
- Ta, B.T.T.; Nguyen, D.L.; Jala, I.; Dontumprai, R.; Plumworasawat, S.; Aighewi, O.; Ong, E.; Shawley, A.; Potriquet, J.; Saichua, P.; Diepen, A. van; Sripa, B.; Hokke, C.H. & Suttiprapa, S. (2020), Identification, recombinant protein production, and functional analysis of a M60-like metallopeptidase, secreted by the liver fluke Opisthorchis viverrini, Parasitology International 75.
- Quik, M.; Hokke, C.H. & Everts, B. (2020), The role of O-GlcNAcylation in immunity against infections, Immunology 161(3): 175-185.
- Kuipers, M.E.; Nolte-'t Hoen, E.N.M.; Ham, A.J. van der; Ozir-Fazalalikhan, A.; Nguyen, D.L.; Korne, C.M. de; Koning, R.I.; Tomes, J.J.; Hoffmann, K.F.; Smits, H.H. & Hokke, C.H. (2020), DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells, Journal of Extracellular Vesicles 9(1).
- Ittiprasert, W.; Mann, V.H.; Karinshak, S.E.; Coghlan, A.; Rinaldi, G.; Sankaranarayanan, G.; Chaidee, A.; Tanno, T.; Kumkhaek, C.; Prangtaworn, P.; Mentink-Kane, M.M.; Cochran, C.J.; Driguez, P.; Holroyd, N.; Tracey, A.; Rodpai, R.; Everts, B.; Hokke, C.H.; Hoffmann, K.F.; Berriman, M. & Brindley, P.J. (2019), Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni, eLife 8.
- Yang, Y.Y.M.; Wilson, R.A.; Thomas, S.R.L.; Kariuki, T.M.; Diepen, A. van & Hokke, C.H. (2019), Micro Array-Assisted Analysis of Anti-Schistosome Glycan Antibodies Elicited by Protective Vaccination With Irradiated Cercariae, Journal of Infectious Diseases 219(10): 1671-1680.
- Nkurunungi, G.; Diepen, A. van; Nassuuna, J.; Sanya, R.E.; Nampijja, M.; Nambuya, I.; Kabagenyi, J.; Serna, S.; Reichardt, N.C.; Ree, R. van; Webb, E.L.; Elliott, A.M.; Yazdanbakhsh, M. & Hokke, C.H. (2019), Microarray assessment of N-glycan-specific IgE and IgG profiles associated with Schistosoma mansoni infection in rural and urban Uganda, Scientific Reports 9.
- Farias, L.P.; Chalmers, L.W.; Perally, S.; Rofatto, H.K.; Jackson, C.J.; Brown, M.; Khouri, M.I.; Barbosa, M.M.F.; Hensbergen, P.J.; Hokke, C.H.; Leite, L.C.C. & Hoffmann, K.F. (2019), Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity, International Journal for Parasitology 49(8): 593-599.
- Langenberg, M.C.C.; Hoogerwerf, M.A.; Janse, J.J.; Lieshout, L. van; Corstjens, P.L.A.M.; Roestenberg, M.; Dam, G.J. van; Diepen, A. van; Dood, C.J. de; Feijt, C.; Ganesh, M.S.; Gerritsma, H.; Hardeman, G.; Hokke, C.H.; Koopman, J.P.R.; Kos-van Oosterhoud, J.; Kruize, Y.C.M.; Meij, P.; Ozir-Fazalalikhan, A.; Schuijlenburg, R. van; Smits, H.H.; Verbeek-Menken, P.H.; Visser, L.G.; Vries, J.J.C. de; Winkel, B.M.F.; Yazdanbakhsh, M. & CoHSI Clinical Trial Team (2019), Katayama Syndrome Without Schistosoma mansoni Eggs, Annals of Internal Medicine 170(10): 732-+.
- Kildemoes, A.O.; Diepen, A. van; Veldhuizen, T.; Nguyen, L.; Tanaka, M.; Dam, G.J. van; Roestenberg, M.; Hamano, S. & Hokke, C.H. (2019), THE DIAGNOSTIC POTENTIAL OF GLYCAN SPECIFIC ANTIBODIES IN SCHISTOSOMIASIS ASSESSED BY GLYCAN MICROARRAYS, American Journal of Tropical Medicine and Hygiene 101: 214-214.
- Kytidou K., Beekwilder J., Artola M., Meel E. van, Wilbers R.H.P., Moolenaar G.F., Goosen N., Ferraz M.J., Katzy R., Voskamp P., Florea B.I., Hokke C.H., Overkleeft H.S., Schots A., Bosch D., Pannu N. & Aerts J.M.F.G. (2018), Nicotiana benthamiana α-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease, Journal of Biological Chemistry 293(26): 10042-10058.
- Es D. van der, Berni F., Hogendorf W.F.J., Meeuwenoord N., Laverde D., Diepen A. van, Overkleeft H.S., Filippov D.V., Hokke C.H., Huebner J., Marel G.A. van der & Codée J.D.C. (2018), Streamlined Synthesis and Evaluation of Teichoic Acid Fragments, Chemistry: a European Journal 24(16): 4014-4018.
- Rolot, M.; Dougall, A.M.; Chetty, A.; Javaux, J.; Chen, T.; Xiao, X.; Machiels, B.; Selkirk, M.E.; Maizels, R.M.; Hokke, C.; Denis, O.; Brombacher, F.; Vanderplasschen, A.; Gillet, L.; Horsnell, W.G.C. & Dewals, B.G. (2018), Helminth-induced IL-4 expands bystander memory CD8(+) T cells for early control of viral infection, Nature Communications 9.
- Huettner Isabella, Krumm Stefanie, Brzezicka Katarzyna, Serna Sonia, van Diepen Angela, Reichardt Niels, Hokke Ron, Angulo Jesus & Doores Katie (2018), Cross-reactivity Between HIV-1 bNAbs and Parasite Glycans, AIDS Research and Human Retroviruses 34: 327-327.
- Kuipers, M.E.; Hokke, C.H.; Smits, H.H. & Hoene, E.N.M.N.'. (2018), Pathogen-Derived Extracellular Vesicle-Associated Molecules That Affect the Host Immune System: An Overview, Frontiers in Microbiology 9.
- Es, D. van der; Berni, F.; Hogendorf, W.F.J.; Meeuwenoord, N.; Laverde, D.; Diepen, A. van; Overkleeft, H.S.; Filippov, D.V.; Hokke, C.H.; Huebner, J.; Marel, G.A. van der & Codee, J.D.C. (2018), Streamlined Synthesis and Evaluation of Teichoic Acid Fragments, Chemistry - A European Journal 24(16): 4014-4018.
- Kytidou, K.; Beekwilder, J.; Artola, M.; Meel, E. van; Wilbers, R.H.P.; Moolenaar, G.F.; Goosen, N.; Ferraz, M.J.; Katzy, R.; Voskamp, P.; Florea, B.I.; Hokke, C.H.; Overkleeft, H.S.; Schots, A.; Bosch, D.; Pannu, N. & Aerts, J.M.F.G. (2018), Nicotiana benthamiana -galactosidase A1.1 can functionally complement human -galactosidase A deficiency associated with Fabry disease, Journal of Biological Chemistry 293(26): 10042-10058.
- Amoah, A.S.; Asuming-Brempong, E.K.; Obeng, B.B.; Versteeg, S.A.; Larbi, I.A.; Aryeetey, Y.; Platts-Mills, T.A.E.; Mari, A.; Brzezicka, K.; Gyan, B.A.; Mutocheluh, M.; Boakye, D.A.; Reichardt, N.C.; Ree, R. van; Hokke, C.H.; Diepen, A. van & Yazdanbakhsh, M. (2018), Identification of dominant anti-glycan IgE responses in school children by glycan microarray, Journal of Allergy and Clinical Immunology 141(3): 1130-+.
- Yang, Y.Y.M.; Diepen, A. van; Brzezicka, K.; Reichardt, N.C. & Hokke, C.H. (2018), Glycan Microarray-Assisted Identification of IgG Subclass Targets in Schistosomiasis, Frontiers in Immunology 9.
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- Yoshino TP, Dinguirard N, Kunert J & Hokke CH (2008), Molecular and functional characterization of a tandem-repeat galectin from the freshwater snail Biomphalaria glabrata, intermediate host of the human blood fluke Schistosoma mansoni, Gene 411(1-2).
- Bakker H, Johswich A, Kraft B, Wuhrer M, Hokke CH & Gerardy-Schahn R (2008), Mechanism of Interaction between Drosophila beta 4GalNAcTB and the beta 4GalNAcTB Pilot Protein (GABPI), Glycobiology 18(11): 993-993.
- Hokke C (2008), Parasite glycobiology: Schistosome glycans in parasite-host interaction and development, Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology 150(3).
- Ruhaak LR, Huhn C, Waterreus WJ, de Boer AR, Neususs C, Hokke CH, Deelder AM & Wuhrer M (2008), Hydrophilic interaction chromatography-based high-throughput sample preparation method for N-glycan analysis from total human plasma glycoproteins, Analytical Chemistry 80(15).
- Robijn MLM, Planken J, Kornelis D, Hokke CH & Deelder AM (2008), Mass spectrometric detection of urinary oligosaccharides as markers of Schistosoma mansoni infection, Transactions of The Royal Society of Tropical Medicine and Hygiene 102(1).
- de Boer AR, Hokke CH, Deelder AM & Wuhrer M (2008), Serum antibody screening by surface plasmon resonance using a natural glycan microarray, Glycoconjugate Journal 25(1).
- Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M & Bakker H (2008), Distinct contributions of beta 4GalNAcTA and beta 4GalNAcTB to Drosophila glycosphingolipid biosynthesis, Glycoconjugate Journal 25(2).
- Boer B.A. de, Hokke C.H., Deelder A.M. & Wuhrer M. (2007), General microarray technique for immobilization and screening of natural glycans, Analytical Chemistry 79(21): 8107-13.
- Hokke C.H., Deelder A.M., Hoffmann K.F. & Wuhrer M. (2007), Glycomics-driven discoveries in schistosome research, Experimental Parasitology 117(3): 275-83.
- Wuhrer M, Stam JC, van de Geijn FE, Koeleman CAM, Verrips CT, Dolhain RJEM, Hokke CH & Deelder AM (2007), Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum, Proteomics 7(22).
- de Boer AR, Hokke CH, Deelder AM & Wuhrer M (2007), General microarray technique for immobilization and screening of natural glycans, Analytical Chemistry 79(21).
- Hokke CH, Fitzpatrick JM & Hoffmann KF (2007), Integrating transcriptome, proteome and glycome analyses of Schistosoma biology, Trends in Parasitology 23(4).
- Wuhrer M, Catalina MI, Deelder AM & Hokke CH (2007), Glycoproteomics based on tandem mass spectrometry of glycopeptides, Journal of Chromatography B 849(1-2).
- Robijn MLM, Koeleman CAM, Wuhrer M, Royle L, Geyer R, Dwek RA, Rudd PM, Deelder AM & Hokke CH (2007), Targeted identification of a unique glycan epitope of Schistosoma mansoni egg antigens using a diagnostic antibody, Molecular and Biochemical Parasitology 151(2).
- Rouwendal GJA, Wuhrer M, Florack DEA, Koeleman CAM, Deelder AM, Bakker H, Stoopen GM, van Die I, Helsper JPFG, Hokke CH & Bosch D (2007), Efficient introduction of a bisecting GlcNAc residue in tobacco N-glycans by expression of the gene encoding human N-acetylglucosaminyltransferase III, Glycobiology 17(3).
- Robijn MLM, Koeleman CAM, Hokke CH & Deelder AM (2007), Schistosoma mansoni eggs excrete specific free oligosaccharides that are detectable in the urine of the human host, Molecular and Biochemical Parasitology 151(2).
- Goselink HM, Nijmeijer BA, Hokke CH, van der Heijden R, Willemze R & Falkenburg JHF (2007), Proliferation of acute lymphoblastic leukemic (ALL) cells is dependent on exogenous purine administration, Blood 110(11).
- Hokke CH, Deelder AM, Hoffmann KF & Wuhrer M (2007), Glycomics-driven discoveries in schistosome research, Experimental Parasitology 117(3).
- Wuhrer M, Balog CIA, Catalina MI, Jones FM, Schramm G, Haas H, Doenhoff MJ, Dunne DW, Deelder AM & Hokke CH (2006), IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans, FEBS Journal 273(10).
- Wuhrer M, Koeleman CAM, Fitzpatrick JM, Hoffmann KF, Deelder AM & Hokke CH (2006), Gender-specific expression of complex-type N-glycans in schistosomes, Glycobiology 16(10).
- Van de Vijver KK, Deelder AM, Jacobs W, Van Marck EA & Hokke CH (2006), LacdiNAc- and LacNAc-containing glycans induce granulomas in an in vivo model for schistosome egg-induced hepatic granuloma formation, Glycobiology 16(3).
- Van de Vijver KK, Colpaert CG, Jacobs W, Kuypers K, Hokke CH, Deelder AM & Van Marck EA (2006), The host's genetic background determines the extent of angiogenesis induced by schistosome egg antigens, Acta Tropica 99(2-3).
- Wuhrer M, Koeleman CAM, Deelder AM & Hokke CH (2006), Repeats of LacdiNAc and fucosylated LacdiNAc on N-glycans of the human parasite Schistosoma mansoni, FEBS Journal 273(2).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2006), Mass spectrometry of proton adducts of fucosylated N-glycans: fucose transfer between antennae gives rise to misleading fragments, Rapid Communications in Mass Spectrometry 20(11).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2005), Protein glycosylation analyzed by normal-phase nano-liquid chromatography-mass spectrometry of glycopeptides, Analytical Chemistry 77(3).
- Tong M, Jacobi CE, van de Rijke FM, Kuijper S, van de Werken S, Lowary TL, Hokke CH, Appelmelk BJ, Nagelkerke NJD, Tanke HJ, van Gijlswijkh RPM, Veuskens J, Kolk AHJ & Raap AK (2005), A multiplexed and miniaturized serological tuberculosis assay identifies antigens that discriminate maximally between TB and non-TB sera, Journal of Immunological Methods 301(1-2).
- Robijn MLM, Wuhrer M, Kornelis D, Deelder AM, Geyer R & Hokke CH (2005), Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs, Parasitology 130.
- Wuhrer M, Balog CIA, Koeleman CAM, Deelder AM & Hokke CH (2005), New features of site-specific horseradish peroxidase (HRP) glycosylation uncovered by nano-LC-MS with repeated ion-isolation/fragmentation cycles, BBA - General Subjects 1723(1-3).
- van Roon AMM, Aguilera B, Cuenca F, van Remoortere A, van der Marel GA, Deelder AM, Overkleeft HS & Hokke CH (2005), Synthesis and antibody-binding studies of a series of parasite fuco-oligosaccharides, Bioorganic and Medicinal Chemistry 13(10).
- Hokke CH & Yazdanbakhsh M (2005), Schistosome glycans and innate immunity, Parasite Immunology 27(7-8).
- de Souza AC, van Remoortere A, Hokke CH, Deelder AM, Vliegenthart JFG & Kamerling JR (2005), Determination of the specificity of monoclonal antibodies against Schistosoma mansoni CAA glycoprotein antigen using neoglycoconjugate variants, Biological Chemistry 386(9).
- Wuhrer M, Deelder AM & Hokke CH (2005), Protein glycosylation analysis by liquid chromatography-mass spectrometry, Journal of Chromatography B 825(2).
- Fitzsimmons CM, Schramm G, Jones FM, Chalmers IW, Hoffmann KE, Grevelding CG, Wuhrer M, Hokke CH, Haas H, Doenhoff MJ & Dunne DW (2005), Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs, Molecular and Biochemical Parasitology 144(1).
- Bruggink C, Wuhrer M, Koeleman CAM, Barreto V, Liu Y, Pohl C, Ingendoh A, Hokke CH & Deelder AM (2005), Oligosaccharide analysis by capillary-scale high-pH anion-exchange chromatography with on-line ion-trap mass spectrometry, Journal of Chromatography B 829(1-2).
- van de Wetering JK, van Remoortere A, Vaandrager AB, Batenburg JJ, van Golde LMG, Hokke CH & van Hellemond JJ (2004), Surfactant protein D binding to terminal alpha 1-3-linked fucose residues and to Schistosoma mansoni, American Journal of Respiratory Cell and Molecular Biology 31(5).
- Mayboroda OA, van Remoortere A, Tanke HJ, Hokke CH & Deelder AM (2004), A new approach for fluorescence correlation spectroscopy (FCS) based immunoassays, Journal of Biotechnology 107(2).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2004), Nano-scale liquid chromatography-mass spectrometry of 2-aminobenzamide-labeled oligosaccharides at low femtomole sensitivity, International Journal of Mass Spectrometry 232(1).
- de Vijver KKV, Hokke CH, van Remoortere A, Jacobs W, Deelder AM & Van Marck EA (2004), Glycans of Schistosoma mansoni and keyhole limpet haemocyanin induce hepatic granulomas in vivo, International Journal for Parasitology 34(8).
- van Roon AMM, Pannu NS, de Vrind JPM, van der Marel GA, van Boom JH, Hokke CH, Deelder AM & Abrahams JP (2004), Structure of an anti-Lewis X fab fragment in complex with its Lewis X antigen, Structure 12(7).
- Wuhrer M, Hokke CH & Deelder AM (2004), Glycopeptide analysis by matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry reveals novel features of horseradish peroxidase glycosylation, Rapid Communications in Mass Spectrometry 18(15).
- Van Roon AMM, Van de Vijver KK, Jacobs W, Van Marck EA, Van Dam GJ, Hokke CH & Deelder AM (2004), Discrimination between the anti-monomeric and the anti-multimeric Lewis X response in murine schistosomiasis, Microbes and Infection 6(13).
- van der Boog PJM, van Kooten C, van Zandbergen G, Klar-Mohamad N, Oortwijn B, Bos NA, van Remoortere A, Hokke CH, de Fijter JW & Daha MR (2004), Injection of recombinant Fc alpha RI/CD89 in mice does not induce mesangial IgA deposition, Nephrology Dialysis Transplantation 19(11).
- Wuhrer M, Koeleman CAM, Deelder AM & Hokke CN (2004), Normal-phase nanoscale liquid chromatography - Mass spectrometry of underivatized oligosaccharides at low-femtomole sensitivity, Analytical Chemistry 76(3).
- van den Berg TK, Honing H, Franke N, van Remoortere A, Schiphorst WECM, Liu FT, Deelder AM, Cummings RD, Hokke CH & van Die I (2004), LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition, Journal of Immunology 173(3).
- Wuhrer M, Robijn MLM, Koeleman CAM, Balog CIA, Geyer R, Deelder AM & Hokke CH (2004), A novel Gal(beta 1-4)Gal(beta 1-4)Fuc(alpha 1-6)-core modification attached to the proximal N-acetylglucosamine of keyhole limpet haemocyanin (KLH) N-glycans, Biochemical Journal 378.
- van Roon AMM, Pannu NS, Hokke CH, Deelder AM & Abrahams JP (2003), Crystallization and preliminary X-ray analysis of an anti-LewisX Fab fragment with and without its LewisX antigen, Acta Crystallographica Section D: Biological Crystallography 59.
- Naus CWA, van Remoortere A, Ouma JH, Kimani G, Dunne DW, Kamerling JP, Deelder AM & Hokke CH (2003), Specific antibody responses to three schistosome-related carbohydrate structures in recently exposed immigrants and established residents in an area of Schistosoma mansoni endemicity, Infection and Immunity 71(10).
- Vermeer HJ, van Dam GJ, Halkes KM, Kamerling JP, Vliegenthart JFG, Hokke CH & Deelder AM (2003), Immunodiagnostically applicable monoclonal antibodies to the circulating anodic antigen of Schistosoma mansoni bind to small, defined oligosaccharide epitopes, Parasitology Research 90(4).
- van Remoortere A, Vermeer HJ, van Roon AM, Langermans JA, Thomas AW, Wilson RA, van Die I, van den Eijnden DH, Agoston K, Kerekgyarto J, Vliegenthart JFG, Kamerling JP, van Dam GJ, Hokke CH & Deelder AM (2003), Dominant antibody responses to Fuc alpha 1-3GalNAc and Fuc alpha 1-2Fuc alpha 1-3GlcNAc containing carbohydrate epitopes in Pan troglodytes vaccinated and infected with Schistosoma mansoni, Experimental Parasitology 105(3-4).
- Van der Kleij D, Van Remoortere A, Schuitemaker JHN, Kapsenberg ML, Deelder AM, Tielens AGM, Hokke CH & Yazdanbakhsh M (2002), Triggering of innate immune responses by schistosome egg glycolipids and their carbohydrate epitope GalNAc beta 1-4(Fuc alpha 1-2Fuc alpha 1-3)GlcNAc, Journal of Infectious Diseases 185(4).
- van Remoortere A, van Dam GJ, Hokke CH, van den Eijnden DH, van Die I & Deelder AM (2001), Profiles of immunoglobulin M (IgM) and IgG antibodies against defined carbohydrate epitopes in sera of Schistosoma-infected individuals determined by surface plasmon resonance, Infection and Immunity 69(4).
- van Remoortere A, Hokke CH, van Dam GJ, van Die I, Deelder AM & van den Eijnden DH (2000), Various stages of Schistosoma express Lewis(x), LacdiNAc, GalNAc beta 1-4 (Fuc alpha 1-3)GlcNAc and GalNAc beta 1-4(Fuc alpha 1-2Fuc alpha 1-3)GlcNAc carbohydrate epitopes: detection with monoclonal antibodies that are characterized by enzymatically synthesized neoglycoproteins.
- Editorial Board Member 'Parasitology International'
- Editorial Board Member 'Glycoconjugate Journal'